Jonathan H. Sheehan, Ph.D.
Affiliations: | 2006 | Vanderbilt University, Nashville, TN |
Area:
BiochemistryGoogle:
"Jonathan Sheehan"Parents
Sign in to add mentor| Walter J. Chazin | grad student | 2006 | Vanderbilt | |
| (Probing functional diversity of EF -hand calcium binding proteins through mutant design and structural analysis.) | ||||
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Publications
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| Maddur AA, Kroh HK, Aschenbrenner ME, et al. (2020) Specificity and affinity of the N-terminal residues in staphylocoagulase in binding to prothrombin. The Journal of Biological Chemistry |
| Hanker AB, Jayanthan HS, Ye D, et al. (2020) Abstract GS6-04: Co-occurring gain-of-function mutations in HER2 and HER3 modulate HER2/HER3 activation, breast cancer progression, and HER2 inhibitor sensitivity Cancer Research. 80 |
| Hanker A, Koch J, Ye D, et al. (2019) Abstract PD3-05: Co-occurring gain-of-function mutations in HER2 and HER3 cooperate to enhance HER2/HER3 binding, HER-dependent signaling, and breast cancer growth Cancer Research |
| Du Z, Gallant J, Red-Brewer M, et al. (2019) Abstract 867: EGFR kinase domain duplication (EGFR-KDD) is activated by asymmetric intra-molecular dimerization Cancer Research. 79: 867-867 |
| Croessmann S, Sheehan JH, Lee KM, et al. (2017) PIK3CA C2 domain deletions hyperactivate phosphoinositide 3-kinase (PI3K), generate oncogene dependence and are exquisitely sensitive to PI3Kα inhibitors. Clinical Cancer Research : An Official Journal of the American Association For Cancer Research |
| Kharade S, Sheehan J, Figueroa E, et al. (2017) Pore polarity and charge determine differential block of Kir1.1 and Kir7.1 potassium channels by the small-molecule inhibitor VU590. Molecular Pharmacology |
| Hanker AB, Red Brewer M, Sheehan JH, et al. (2017) An Acquired HER2 T798I Gatekeeper Mutation Induces Resistance to Neratinib in a Patient with HER2 Mutant-Driven Breast Cancer. Cancer Discovery |
| Croessmann S, Sheehan J, Sliwoski G, et al. (2017) Abstract 1772:PIK3CAC2 domain deletions hyperactivate PI3K, generate oncogene dependence and are exquisitely sensitive to PI3Kα inhibitors Cancer Research. 77: 1772-1772 |
| Du Z, Gallant J, Sheehan J, et al. (2017) Intramolecular Dimerization of EGFR Kinase Domain Duplication as a Novel Activation Mechanism Journal of Thoracic Oncology. 12: S1536 |
| Swale DR, Sheehan JH, Banerjee S, et al. (2015) Computational and functional analyses of a small-molecule binding site in ROMK. Biophysical Journal. 108: 1094-103 |