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Evan D. Brutinel, Ph.D.

Affiliations: 
2008 University of Iowa, Iowa City, IA 
Area:
Microbiology Biology, Molecular Biology
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"Evan Brutinel"
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Timothy L. Yahr grad student 2008 University of Iowa
 (DNA binding properties and domain function of ExsA; The central transcriptional regulator of the Pseudomonas aeruginosa type III secretion system.)

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Coggan KA, Higgs MG, Brutinel ED, et al. (2022) Global Regulatory Pathways Converge To Control Expression of Pseudomonas aeruginosa Type IV Pili. Mbio. e0369621
King JM, Brutinel ED, Marsden AE, et al. (2012) Orientation of Pseudomonas aeruginosa ExsA monomers bound to promoter DNA and base-specific contacts with the P(exoT) promoter. Journal of Bacteriology. 194: 2573-85
Brutinel ED, King JM, Marsden AE, et al. (2012) The distal ExsA-binding site in Pseudomonas aeruginosa type III secretion system promoters is the primary determinant for promoter-specific properties. Journal of Bacteriology. 194: 2564-72
Fuchs EL, Brutinel ED, Jones AK, et al. (2010) The Pseudomonas aeruginosa Vfr regulator controls global virulence factor expression through cyclic AMP-dependent and -independent mechanisms. Journal of Bacteriology. 192: 3553-64
Vakulskas CA, Brutinel ED, Yahr TL. (2010) ExsA recruits RNA polymerase to an extended -10 promoter by contacting region 4.2 of sigma-70. Journal of Bacteriology. 192: 3597-607
Fuchs EL, Brutinel ED, Klem ER, et al. (2010) In vitro and in vivo characterization of the Pseudomonas aeruginosa cyclic AMP (cAMP) phosphodiesterase CpdA, required for cAMP homeostasis and virulence factor regulation. Journal of Bacteriology. 192: 2779-90
Brutinel ED, Vakulskas CA, Yahr TL. (2010) ExsD inhibits expression of the Pseudomonas aeruginosa type III secretion system by disrupting ExsA self-association and DNA binding activity. Journal of Bacteriology. 192: 1479-86
Brutinel ED, Vakulskas CA, Yahr TL. (2009) Functional domains of ExsA, the transcriptional activator of the Pseudomonas aeruginosa type III secretion system. Journal of Bacteriology. 191: 3811-21
Brutinel ED, Yahr TL. (2008) Control of gene expression by type III secretory activity. Current Opinion in Microbiology. 11: 128-33
Brutinel ED, Vakulskas CA, Brady KM, et al. (2008) Characterization of ExsA and of ExsA-dependent promoters required for expression of the Pseudomonas aeruginosa type III secretion system. Molecular Microbiology. 68: 657-71
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