Jonathan H. LeBowitz
Affiliations: | Purdue University, West Lafayette, IN, United States |
Area:
Biochemistry, Molecular Biology, Cell Biology, Microbiology Biology, PathologyGoogle:
"Jonathan LeBowitz"
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Publications
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| Luu AR, Wong H, Agrawal V, et al. (2020) Lysosome-targeted β-galactosidase negatively regulates neuraminidase 1 (NEU1) and promotes NEU1 deficiency in GM1 gangliosidosis. The Journal of Biological Chemistry |
| Grover A, Crippen-Harmon D, Nave L, et al. (2020) Translational studies of intravenous and intracerebroventricular routes of administration for CNS cellular biodistribution for BMN 250, an enzyme replacement therapy for the treatment of Sanfilippo type B. Drug Delivery and Translational Research |
| Chen JC, Luu AR, Wise N, et al. (2019) Intracerebroventricular enzyme replacement therapy with Beta-Galactosidase reverses brain pathologies due to GM1 gangliosidosis in mice. The Journal of Biological Chemistry |
| Prill H, Luu A, Yip B, et al. (2019) Differential Uptake of NAGLU-IGF2 and Unmodified NAGLU in Cellular Models of Sanfilippo Syndrome Type B. Molecular Therapy. Methods & Clinical Development. 14: 56-63 |
| Yogalingam G, Luu AR, Prill H, et al. (2019) BMN 250, a fusion of lysosomal alpha-N-acetylglucosaminidase with IGF2, exhibits different patterns of cellular uptake into critical cell types of Sanfilippo syndrome B disease pathogenesis. Plos One. 14: e0207836 |
| Aoyagi-Scharber M, Crippen-Harmon D, Lawrence R, et al. (2017) Clearance of Heparan Sulfate and Attenuation of CNS Pathology by Intracerebroventricular BMN 250 in Sanfilippo Type B Mice. Molecular Therapy. Methods & Clinical Development. 6: 43-53 |
| Yogalingam G, Lee AR, Mackenzie DS, et al. (2017) Cellular uptake and delivery of Myeloperoxidase to lysosomes promotes lipofuscin degradation and lysosomal stress in retinal cells. The Journal of Biological Chemistry |
| Yogalingam G, Prill H, Lee A, et al. (2016) Glycosylation independent lysosomal targeting of alpha-n-acetylglucosaminidase confers highly efficient enzyme uptake into critical cellular targets of disease pathogenesis in mucopolysaccharidosis type IIIB Molecular Genetics and Metabolism. 117: S122 |
| Aoyagi-Scharber M, Vincelette J, Lawrence R, et al. (2016) Time- and dose-dependent normalization of pathological lysosomal storage and biochemistry in the mucopolysaccharidosis ΙΙΙΒ (MPS ΙΙΙΒ, Sanfilippo syndrome type Β) mouse model by intracerebroventricular enzyme replacement therapy with ΒΜΝ 250, a ΝAGLU-ΙGF2 fusion pro Molecular Genetics and Metabolism. 117: S21 |
| Kan SH, Aoyagi-Scharber M, Le SQ, et al. (2014) Delivery of an enzyme-IGFII fusion protein to the mouse brain is therapeutic for mucopolysaccharidosis type IIIB. Proceedings of the National Academy of Sciences of the United States of America. 111: 14870-5 |