David T. Scadden

Harvard University, Cambridge, MA, United States 
Microbiology Biology, Molecular Biology, Oncology
"David Scadden"


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Nicole A. McNeer research assistant 2008 Harvard Medical School (BME Tree)
Todd J. Suscovich grad student 2005 Harvard
Nathaniel T. Jeanson grad student 2009 Harvard
Catherine Rhee post-doc 2017- (Chemistry Tree)
Agnieszka D Czechowicz post-doc 2015-2017 Harvard Medical School (Stem Cell Tree)
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Czechowicz A, Palchaudhuri R, Scheck A, et al. (2019) Selective hematopoietic stem cell ablation using CD117-antibody-drug-conjugates enables safe and effective transplantation with immunity preservation. Nature Communications. 10: 617
Hoggatt J, Singh P, Tate TA, et al. (2017) Rapid Mobilization Reveals a Highly Engraftable Hematopoietic Stem Cell. Cell
Sykes DB, Kfoury YS, Mercier FE, et al. (2016) Inhibition of Dihydroorotate Dehydrogenase Overcomes Differentiation Blockade in Acute Myeloid Leukemia. Cell
Silberstein L, Goncalves KA, Kharchenko PV, et al. (2016) Proximity-Based Differential Single-Cell Analysis of the Niche to Identify Stem/Progenitor Cell Regulators. Cell Stem Cell
Goncalves KA, Silberstein L, Li S, et al. (2016) Angiogenin Promotes Hematopoietic Regeneration by Dichotomously Regulating Quiescence of Stem and Progenitor Cells. Cell. 166: 894-906
Yu VW, Lymperi S, Oki T, et al. (2016) Distinctive Mesenchymal-Parenchymal Cell Pairings Govern B Cell Differentiation in the Bone Marrow. Stem Cell Reports
Palchaudhuri R, Saez B, Hoggatt J, et al. (2016) Non-genotoxic conditioning for hematopoietic stem cell transplantation using a hematopoietic-cell-specific internalizing immunotoxin. Nature Biotechnology
Mercier FE, Sykes DB, Scadden DT. (2016) Single Targeted Exon Mutation Creates a True Congenic Mouse for Competitive Hematopoietic Stem Cell Transplantation: The C57BL/6-CD45.1(STEM) Mouse. Stem Cell Reports
Yu VW, Scadden DT. (2016) Heterogeneity of the bone marrow niche. Current Opinion in Hematology
Scadden DT. (2016) Blood and Bone. The New England Journal of Medicine. 374: 1891-3
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