K Heran Darwin

Affiliations: 
Basic Medical Science New York University, New York, NY, United States 
Area:
Microbiology Biology, Genetics
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"Heran Darwin"

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Samuel H Becker grad student NYU
Jordan B Jastrab grad student NYU
Xiaoshan Shi grad student NYU
Michael Pearce grad student 2005-2009 NYU (Chemistry Tree)
Richard A. Festa grad student 2005-2011 NYU (Chemistry Tree)
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Publications

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Limón G, Samhadaneh NM, Pironti A, et al. (2023) Aldehyde accumulation in with defective proteasomal degradation results in copper sensitivity. Mbio. e0036323
Yoo JH, Kahne SC, Darwin KH. (2022) A conserved loop sequence of the proteasome system depupylase Dop regulates substrate selectivity in Mycobacterium tuberculosis. The Journal of Biological Chemistry. 102478
Xiao X, Feng X, Yoo JH, et al. (2022) The β-Grasp Domain of Proteasomal ATPase Mpa Makes Critical Contacts with the Mycobacterium tuberculosis 20S Core Particle to Facilitate Degradation. Msphere. e0027422
Janssen GV, Zhang S, Merkx R, et al. (2021) Development of Tyrphostin Analogues to Study Inhibition of the Mycobacterium tuberculosis Pup Proteasome System. Chembiochem : a European Journal of Chemical Biology
Zhang H, Hsu HC, Kahne SC, et al. (2021) Macrocyclic Peptides that Selectively Inhibit the Proteasome. Journal of Medicinal Chemistry
Yin Y, Kovach A, Hsu HC, et al. (2021) The mycobacterial proteasomal ATPase Mpa forms a gapped ring to engage the 20S proteasome. The Journal of Biological Chemistry. 100713
Kahne SC, Darwin KH. (2020) Structural determinants of regulated proteolysis in pathogenic bacteria by ClpP and the proteasome. Current Opinion in Structural Biology. 67: 120-126
Becker SH, Ulrich K, Dhabaria A, et al. (2020) Mycobacterium tuberculosis Rv0991c Is a Redox-Regulated Molecular Chaperone. Mbio. 11
Ji DX, Yamashiro LH, Chen KJ, et al. (2019) Type I interferon-driven susceptibility to Mycobacterium tuberculosis is mediated by IL-1Ra. Nature Microbiology
Ballister ER, Samanovic MI, Darwin KH. (2019) Rv2700 Contributes to Cell Envelope Integrity and Virulence. Journal of Bacteriology
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