Wen-Hwa Lee

Biomedical Sciences - Ph.D. University of California, Irvine, Irvine, CA 
Molecular Biology, Biochemistry, Microbiology Biology, Genetics
"Wen-Hwa Lee"


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Peter H. Duesberg grad student (Neurotree)


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Bryan Ngo research assistant UC Irvine School of Medicine (Chemistry Tree)
Saori Furuta grad student 2007 UC Irvine
Lily Khidr grad student 2008 UC Irvine
Randy L. Wei grad student 2010 UC Irvine
Xuning E. Guo grad student 2011 UC Irvine
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Hsu JL, Chou JW, Chen TF, et al. (2019) Glutathione peroxidase 8 negatively regulates caspase-4/11 to protect against colitis. Embo Molecular Medicine. e9386
Hsieh YL, Su FY, Tsai LK, et al. (2019) NPGPx-Mediated Adaptation to Oxidative Stress Protects Motor Neurons from Degeneration in Aging by Directly Modulating O-GlcNAcase. Cell Reports. 29: 2134-2143.e7
Hu CM, Tien SC, Hsieh PK, et al. (2019) High Glucose Triggers Nucleotide Imbalance through O-GlcNAcylation of Key Enzymes and Induces KRAS Mutation in Pancreatic Cells. Cell Metabolism
Chen YL, Hu CM, Hsu JT, et al. (2018) Cellular 5-hydroxylmethylcytosine content determines tumorigenic potential and prognosis of pancreatic ductal adenocarcinoma. American Journal of Cancer Research. 8: 2548-2563
Peng HY, Chang MC, Hu CM, et al. (2018) Thrombospondin-2 is a Highly Specific Diagnostic Marker and is Associated with Prognosis in Pancreatic Cancer. Annals of Surgical Oncology
Huang SC, Wei PC, Hwang-Verslues WW, et al. (2017) TGF-β1 secreted by Tregs in lymph nodes promotes breast cancer malignancy via up-regulation of IL-17RB. Embo Molecular Medicine
Huang CK, Chang PH, Kuo WH, et al. (2017) Adipocytes promote malignant growth of breast tumours with monocarboxylate transporter 2 expression via β-hydroxybutyrate. Nature Communications. 8: 14706
Zhu J, Chen H, Guo XE, et al. (2015) Synthesis, molecular modeling, and biological evaluation of novel RAD51 inhibitors. European Journal of Medicinal Chemistry. 96: 196-208
Hu CM, Zhu J, Guo XE, et al. (2015) Novel small molecules disrupting Hec1/Nek2 interaction ablate tumor progression by triggering Nek2 degradation through a death-trap mechanism. Oncogene. 34: 1220-30
Wang DD, Guo XE, Modrek AS, et al. (2014) Helicase SUV3, polynucleotide phosphorylase, and mitochondrial polyadenylation polymerase form a transient complex to modulate mitochondrial mRNA polyadenylated tail lengths in response to energetic changes. The Journal of Biological Chemistry. 289: 16727-35
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