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Alan Eastman

Affiliations: 
Dartmouth College, Hanover, NH, United States 
Area:
Pharmacology, Cell Biology, Molecular Biology
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"Alan Eastman"
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Parents

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Children

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Michael A. Barry grad student Dartmouth (Cell & Gene Therapy Tree)
Kathryn Chatfield grad student 2003 Dartmouth
Neema Ganju grad student 2003 Dartmouth
Kyle S. MacLea grad student 2003 Dartmouth
Ethan A. Kohn grad student 2004 Dartmouth
Bethany L. Salerni grad student 2009 Dartmouth
Kristen M. Garner grad student 2010 Dartmouth
Ting-Lan T. Albershardt grad student 2011 Dartmouth
Li-Ju Chang grad student 2012 Dartmouth

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Publications

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Hinds JW, Ditano JP, Eastman A. (2021) Inhibition of Protein Synthesis Induced by CHK1 Inhibitors Discriminates Sensitive from Resistant Cancer Cells. Acs Pharmacology & Translational Science. 4: 1449-1461
Ditano JP, Sakurikar N, Eastman A. (2021) Activation of CDC25A phosphatase is limited by CDK2/cyclin A-mediated feedback inhibition. Cell Cycle (Georgetown, Tex.). 1-12
Ditano JP, Eastman A. (2021) Comparative Activity and Off-Target Effects in Cells of the CHK1 Inhibitors MK-8776, SRA737, and LY2606368. Acs Pharmacology & Translational Science. 4: 730-743
Ditano JP, Donahue KL, Tafe LJ, et al. (2021) Sensitivity of cells to ATR and CHK1 inhibitors requires hyperactivation of CDK2 rather than endogenous replication stress or ATM dysfunction. Scientific Reports. 11: 7077
Mallick DJ, Eastman A. (2020) AT101 [(-)-Gossypol] Selectively Inhibits MCL1 and Sensitizes Carcinoma to BH3 Mimetics by Inducing and Stabilizing NOXA. Cancers. 12
Warren NJH, Donahue KL, Eastman A. (2019) Differential Sensitivity to CDK2 Inhibition Discriminates the Molecular Mechanisms of CHK1 Inhibitors as Monotherapy or in Combination with the Topoisomerase I Inhibitor SN38. Acs Pharmacology & Translational Science. 2: 168-182
Warren NJH, Eastman A. (2019) Comparison of the different mechanisms of cytotoxicity induced by checkpoint kinase I inhibitors when used as single agents or in combination with DNA damage. Oncogene
Mallick DJ, Korotkov A, Li H, et al. (2019) Nuphar alkaloids induce very rapid apoptosis through a novel caspase-dependent but BAX/BAK-independent pathway. Cell Biology and Toxicology
Mallick DJ, Soderquist RS, Bates D, et al. (2019) Confounding off-target effects of BH3 mimetics at commonly used concentrations: MIM1, UMI-77, and A-1210477. Cell Death & Disease. 10: 185
Warren NJH, Eastman A. (2019) Reply to Koh: Signaling dynamics of DNA damage response invoked by combination therapy are dose-dependent. The Journal of Biological Chemistry. 294: 2192
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