Jose C. Clemente, Ph.D.
Affiliations: | 2003 | University of Florida, Gainesville, Gainesville, FL, United States |
Area:
BiochemistryGoogle:
"Jose Clemente"Parents
Sign in to add mentor| Ben M. Dunn | grad student | 2003 | UF Gainesville | |
| (Analysis of therapy selected non-active site mutations in the HIV -1 protease.) | ||||
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Publications
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| Schalk-Hihi C, Schubert C, Alexander R, et al. (2011) Crystal structure of a soluble form of human monoglyceride lipase in complex with an inhibitor at 1.35 Ã… resolution. Protein Science : a Publication of the Protein Society. 20: 670-83 |
| Janka L, Clemente J, Vaiana N, et al. (2008) Targeting the plasmepsin 4 orthologs of Plasmodium sp. with "double drug" inhibitors. Protein and Peptide Letters. 15: 868-73 |
| Clemente JC, Robbins A, Graña P, et al. (2008) Design, synthesis, evaluation, and crystallographic-based structural studies of HIV-1 protease inhibitors with reduced response to the V82A mutation. Journal of Medicinal Chemistry. 51: 852-60 |
| Moose RE, Clemente JC, Jackson LR, et al. (2007) Analysis of binding interactions of pepsin inhibitor-3 to mammalian and malarial aspartic proteases. Biochemistry. 46: 14198-205 |
| Gutiérrez-de-Terán H, Nervall M, Dunn BM, et al. (2006) Computational analysis of plasmepsin IV bound to an allophenylnorstatine inhibitor. Febs Letters. 580: 5910-6 |
| Clemente JC, Coman RM, Thiaville MM, et al. (2006) Analysis of HIV-1 CRF_01 A/E protease inhibitor resistance: structural determinants for maintaining sensitivity and developing resistance to atazanavir. Biochemistry. 45: 5468-77 |
| Clemente JC, Govindasamy L, Madabushi A, et al. (2006) Structure of the aspartic protease plasmepsin 4 from the malarial parasite Plasmodium malariae bound to an allophenylnorstatine-based inhibitor. Acta Crystallographica. Section D, Biological Crystallography. 62: 246-52 |
| Ersmark K, Nervall M, Gutiérrez-de-Terán H, et al. (2006) Macrocyclic inhibitors of the malarial aspartic proteases plasmepsin I, II, and IV. Bioorganic & Medicinal Chemistry. 14: 2197-208 |
| Madabushi A, Chakraborty S, Fisher SZ, et al. (2005) Crystallization and preliminary X-ray analysis of the aspartic protease plasmepsin 4 from the malarial parasite Plasmodium malariae. Acta Crystallographica. Section F, Structural Biology and Crystallization Communications. 61: 228-31 |
| Ersmark K, Nervall M, Hamelink E, et al. (2005) Synthesis of malarial plasmepsin inhibitors and prediction of binding modes by molecular dynamics simulations. Journal of Medicinal Chemistry. 48: 6090-106 |