Jan van de Winkel

Affiliations: 
Immunology University Medical Center Utrecht, Utrecht, Netherlands 
Area:
Immunotherapy
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"Jan van de Winkel"
Bio:

https://profs.library.uu.nl/index.php/profrec/getprofdata/2390/7/8/0

Parents

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Pierre Jean Antoine Capel grad student 1988 Radboud University Nijmegen (Cell Biology Tree)
Robert Arnoud Pieter Koene grad student 1988 Radboud University Nijmegen (Cell Biology Tree)
 (Human monocyte Fcγ receptors. Een wetenschappelijke proeve op het gebied van de geneeskunde en tandheelkunde.)

Children

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Nina van Sorge grad student 2001-2005 UMC Utrecht
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Publications

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Kellner C, Günther A, Humpe A, et al. (2016) Enhancing natural killer cell-mediated lysis of lymphoma cells by combining therapeutic antibodies with CD20-specific immunoligands engaging NKG2D or NKp30. Oncoimmunology. 5: e1058459
Diebolder CA, Beurskens FJ, de Jong RN, et al. (2014) Complement is activated by IgG hexamers assembled at the cell surface. Science (New York, N.Y.). 343: 1260-3
Boross P, Lohse S, Nederend M, et al. (2013) IgA EGFR antibodies mediate tumour killing in vivo. Embo Molecular Medicine. 5: 1213-26
Stemerding AM, Köhl J, Pandey MK, et al. (2013) Staphylococcus aureus formyl peptide receptor-like 1 inhibitor (FLIPr) and its homologue FLIPr-like are potent FcγR antagonists that inhibit IgG-mediated effector functions. Journal of Immunology (Baltimore, Md. : 1950). 191: 353-62
Labrijn AF, Meesters JI, De Goeij BECG, et al. (2013) Efficient generation of stable bispecific IgG1 by controlled Fab-arm exchange Proceedings of the National Academy of Sciences of the United States of America. 110: 5145-5150
Boross P, Jansen JH, de Haij S, et al. (2011) The in vivo mechanism of action of CD20 monoclonal antibodies depends on local tumor burden. Haematologica. 96: 1822-30
Repp R, Kellner C, Muskulus A, et al. (2011) Combined Fc-protein- and Fc-glyco-engineering of scFv-Fc fusion proteins synergistically enhances CD16a binding but does not further enhance NK-cell mediated ADCC Journal of Immunological Methods. 373: 67-78
Overdijk MB, Verploegen S, Van Den Brakel JH, et al. (2011) Epidermal growth factor receptor (EGFR) Antibody-induced antibody-dependent cellular cytotoxicity plays a prominent role in inhibiting tumorigenesis, even of tumor cells insensitive to EGFR signaling inhibition Journal of Immunology. 187: 3383-3390
Lammerts van Bueren JJ, Rispens T, Verploegen S, et al. (2011) Anti-galactose-α-1,3-galactose IgE from allergic patients does not bind α-galactosylated glycans on intact therapeutic antibody Fc domains. Nature Biotechnology. 29: 574-6
Klausz K, Berger S, Lammerts van Bueren JJ, et al. (2011) Complement-mediated tumor-specific cell lysis by antibody combinations targeting epidermal growth factor receptor (EGFR) and its variant III (EGFRvIII). Cancer Science. 102: 1761-8
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