Joseph Larner
Affiliations: | Pharmacology | University of Virginia School of Medicine, Charlottesville, VA, United States |
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"Joseph Larner"Bio:
http://www.jbc.org/content/188/1/17.short
https://www.researchgate.net/profile/Joseph_Larner/publication/232309460_STRUCTURE_OF_GLYCOGENS_AND_AMYLOPECTINS/links/0fcfd50db5e463aaed000000/STRUCTURE-OF-GLYCOGENS-AND-AMYLOPECTINS.pdf
Parents
Sign in to add mentor| Carl F. Cori | grad student | 1951 | Washington University (Neurotree) | |
| Gerty T. Cori | grad student | 1951 | Washington University (Neurotree) | |
| (Enzymatic mechanisms of synthesis and degradation of branch linkages in polysaccharides.) | ||||
| Frederick Sanger | research scientist | MRC-LMB (Chemistry Tree) | ||
Children
Sign in to add trainee| Anna A. DePaoli-Roach | post-doc | (Chemistry Tree) | |
| Peter J. Roach | post-doc |
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Publications
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| Lazarenko R, Geisler J, Bayliss D, et al. (2014) D-chiro-inositol glycan stimulates insulin secretion in pancreatic β cells Molecular and Cellular Endocrinology. 387: 1-7 |
| Heimark D, McAllister J, Larner J. (2014) Decreased myo-inositol to chiro-inositol (M/C) ratios and increased M/C epimerase activity in PCOS theca cells demonstrate increased insulin sensitivity compared to controls. Endocrine Journal. 61: 111-7 |
| Larner J. (2013) Inositol, glycogen, insulin, and six nobelists. The Journal of Biological Chemistry. 288: 12313-24 |
| Pitt J, Thorner M, Brautigan D, et al. (2013) Protection against the synaptic targeting and toxicity of Alzheimer's-associated Aβ oligomers by insulin mimetic chiro-inositols. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. 27: 199-207 |
| Larner J, Brautigan DL, Thorner MO. (2010) D-chiro-inositol glycans in insulin signaling and insulin resistance. Molecular Medicine (Cambridge, Mass.). 16: 543-52 |
| Hans SK, Camara F, Altiti A, et al. (2010) Synthesis of C-glycoside analogues of beta-galactosamine-(1-->4)-3-O-methyl-D-chiro-inositol and assay as activator of protein phosphatases PDHP and PP2Calpha. Bioorganic & Medicinal Chemistry. 18: 1103-10 |
| Gluck G, Anguelova T, Heimark D, et al. (2010) Synergistic Effects of d-Chiro-Inositol and Manganese on Blood Glucose and Body Weight of Streptozotocin-Induced Diabetic Rats Current Bioactive Compounds. 6: 90-96 |
| Larner J, Allen G, Sleevi M, et al. (2009) Molecular mechanism of insulin resistance. Structure and formation of a novel galactosamine disaccharide – A putative insulin mediator Experimental and Clinical Endocrinology & Diabetes. 105: 10-11 |
| Nascimento NR, Lessa LM, Kerntopf MR, et al. (2006) Inositols prevent and reverse endothelial dysfunction in diabetic rat and rabbit vasculature metabolically and by scavenging superoxide. Proceedings of the National Academy of Sciences of the United States of America. 103: 218-23 |
| Larner J. (2006) Insulin and the Stimulation of Glycogen Synthesis. The Road from Glycogen Structure to Glycogen Synthase to Cyclic Amp‐Dependent Protein Kinase to Insulin Mediators Advances in Enzymology and Related Areas of Molecular Biology. 63: 173-231 |