| Year |
Citation |
Score |
| 2023 |
Aguilar-Calvo P, Malik A, Sandoval DR, Barback C, Orrù CD, Standke HG, Thomas OR, Dwyer CA, Pizzo DP, Bapat J, Soldau K, Ogawa R, Riley MB, Nilsson KPR, Kraus A, ... Caughey B, et al. Neuronal Ndst1 depletion accelerates prion protein clearance and slows neurodegeneration in prion infection. Plos Pathogens. 19: e1011487. PMID 37747931 DOI: 10.1371/journal.ppat.1011487 |
0.306 |
|
| 2022 |
Artikis E, Kraus A, Caughey B. Structural biology of ex vivo mammalian prions. The Journal of Biological Chemistry. 102181. PMID 35752366 DOI: 10.1016/j.jbc.2022.102181 |
0.337 |
|
| 2021 |
Kraus A, Hoyt F, Schwartz CL, Hansen B, Artikis E, Hughson AG, Raymond GJ, Race B, Baron GS, Caughey B. High-resolution structure and strain comparison of infectious mammalian prions. Molecular Cell. PMID 34433091 DOI: 10.1016/j.molcel.2021.08.011 |
0.307 |
|
| 2021 |
Nahass GR, Sun Y, Xu Y, Batchelor M, Reilly M, Benilova I, Kedia N, Spehar K, Sobott F, Sessions RB, Caughey BW, Radford SE, Jat P, Collinge J, Bieschke J. Brazilin Removes Toxic alpha-Synuclein and Seeding Competent Assemblies from Parkinson Brain by Altering Conformational Equilibrium. Journal of Molecular Biology. 166878. PMID 33610557 DOI: 10.1016/j.jmb.2021.166878 |
0.326 |
|
| 2020 |
Artikis E, Roy A, Verli H, Cordeiro Y, Caughey B. Accommodation of In-Register N-Linked Glycans on Prion Protein Amyloid Cores. Acs Chemical Neuroscience. PMID 33180459 DOI: 10.1021/acschemneuro.0c00635 |
0.315 |
|
| 2019 |
Caughey B, Kraus A. Transmissibility versus Pathogenicity of Self-Propagating Protein Aggregates. Viruses. 11. PMID 31717531 DOI: 10.3390/v11111044 |
0.309 |
|
| 2019 |
Metrick MA, do Carmo Ferreira N, Saijo E, Hughson AG, Kraus A, Orrú C, Miller MW, Zanusso G, Ghetti B, Vendruscolo M, Caughey B. Million-fold sensitivity enhancement in proteopathic seed amplification assays for biospecimens by Hofmeister ion comparisons. Proceedings of the National Academy of Sciences of the United States of America. PMID 31641070 DOI: 10.1073/Pnas.1909322116 |
0.34 |
|
| 2017 |
Groveman BR, Raymond GJ, Campbell KJ, Race B, Raymond LD, Hughson AG, Orrú CD, Kraus A, Phillips K, Caughey B. Role of the central lysine cluster and scrapie templating in the transmissibility of synthetic prion protein aggregates. Plos Pathogens. 13: e1006623. PMID 28910420 DOI: 10.1371/Journal.Ppat.1006623 |
0.331 |
|
| 2017 |
Kraus A, Raymond GJ, Race B, Campbell KJ, Hughson AG, Anson KJ, Raymond LD, Caughey B. PrP P102L and nearby lysine mutations promote spontaneous in vitro formation of transmissible prions. Journal of Virology. PMID 28835493 DOI: 10.1128/Jvi.01276-17 |
0.394 |
|
| 2017 |
Wang F, Wang X, Orrú CD, Groveman BR, Surewicz K, Abskharon R, Imamura M, Yokoyama T, Kim YS, Vander Stel KJ, Sinniah K, Priola SA, Surewicz WK, Caughey B, Ma J. Self-propagating, protease-resistant, recombinant prion protein conformers with or without in vivo pathogenicity. Plos Pathogens. 13: e1006491. PMID 28704563 DOI: 10.1371/Journal.Ppat.1006491 |
0.3 |
|
| 2016 |
Hughson AG, Race B, Kraus A, Sangaré LR, Robins L, Groveman BR, Saijo E, Phillips K, Contreras L, Dhaliwal V, Manca M, Zanusso G, Terry D, Williams JF, Caughey B. Inactivation of Prions and Amyloid Seeds with Hypochlorous Acid. Plos Pathogens. 12: e1005914. PMID 27685252 DOI: 10.1371/Journal.Ppat.1005914 |
0.32 |
|
| 2016 |
Kellock J, Hopping G, Caughey B, Daggett V. Peptides comprised of alternating L- and D- Amino acids inhibit amyloidogenesis in Three Distinct Amyloid Systems independent of sequence. Journal of Molecular Biology. PMID 27012425 DOI: 10.1016/J.Jmb.2016.03.013 |
0.525 |
|
| 2015 |
Kraus A, Anson KJ, Raymond LD, Martens C, Groveman BR, Dorward DW, Caughey B. Prion protein prolines 102 and 105 and the surrounding lysine cluster impede amyloid formation. The Journal of Biological Chemistry. PMID 26175152 DOI: 10.1074/Jbc.M115.665844 |
0.338 |
|
| 2015 |
Groveman BR, Kraus A, Raymond LD, Dolan MA, Anson KJ, Dorward DW, Caughey B. Charge neutralization of the central lysine cluster in prion protein (PrP) promotes PrP(Sc)-like folding of recombinant PrP amyloids. The Journal of Biological Chemistry. 290: 1119-28. PMID 25416779 DOI: 10.1074/Jbc.M114.619627 |
0.319 |
|
| 2014 |
Groveman BR, Dolan MA, Taubner LM, Kraus A, Wickner RB, Caughey B. Parallel in-register intermolecular β-sheet architectures for prion-seeded prion protein (PrP) amyloids Journal of Biological Chemistry. 289: 24129-24142. PMID 25028516 DOI: 10.1074/Jbc.M114.578344 |
0.407 |
|
| 2014 |
Hopping G, Kellock J, Barnwal RP, Law P, Bryers J, Varani G, Caughey B, Daggett V. Designed α-sheet peptides inhibit amyloid formation by targeting toxic oligomers. Elife. 3: e01681. PMID 25027691 DOI: 10.7554/Elife.01681 |
0.539 |
|
| 2014 |
Vieira TC, Cordeiro Y, Caughey B, Silva JL. Heparin binding confers prion stability and impairs its aggregation. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. 28: 2667-76. PMID 24648544 DOI: 10.1096/Fj.13-246777 |
0.343 |
|
| 2013 |
Hopping G, Kellock J, Caughey B, Daggett V. Designed Trpzip-3 β-Hairpin Inhibits Amyloid Formation in Two Different Amyloid Systems. Acs Medicinal Chemistry Letters. 4: 824-8. PMID 24900756 DOI: 10.1021/Ml300478W |
0.503 |
|
| 2013 |
Kraus A, Groveman BR, Caughey B. Prions and the potential transmissibility of protein misfolding diseases. Annual Review of Microbiology. 67: 543-64. PMID 23808331 DOI: 10.1146/Annurev-Micro-092412-155735 |
0.306 |
|
| 2012 |
Peden AH, McGuire LI, Appleford NE, Mallinson G, Wilham JM, Orrú CD, Caughey B, Ironside JW, Knight RS, Will RG, Green AJ, Head MW. Sensitive and specific detection of sporadic Creutzfeldt-Jakob disease brain prion protein using real-time quaking-induced conversion. The Journal of General Virology. 93: 438-49. PMID 22031526 DOI: 10.1099/vir.0.033365-0 |
0.316 |
|
| 2011 |
Smirnovas V, Baron GS, Offerdahl DK, Raymond GJ, Caughey B, Surewicz WK. Structural organization of brain-derived mammalian prions examined by hydrogen-deuterium exchange. Nature Structural & Molecular Biology. 18: 504-6. PMID 21441913 DOI: 10.1038/Nsmb.2035 |
0.308 |
|
| 2010 |
Kim JI, Cali I, Surewicz K, Kong Q, Raymond GJ, Atarashi R, Race B, Qing L, Gambetti P, Caughey B, Surewicz WK. Mammalian prions generated from bacterially expressed prion protein in the absence of any mammalian cofactors. The Journal of Biological Chemistry. 285: 14083-7. PMID 20304915 DOI: 10.1074/Jbc.C110.113464 |
0.321 |
|
| 2009 |
Smirnovas V, Kim JI, Lu X, Atarashi R, Caughey B, Surewicz WK. Distinct structures of scrapie prion protein (PrPSc)-seeded versus spontaneous recombinant prion protein fibrils revealed by hydrogen/deuterium exchange. The Journal of Biological Chemistry. 284: 24233-41. PMID 19596861 DOI: 10.1074/Jbc.M109.036558 |
0.358 |
|
| 2009 |
Caughey B, Baron GS, Chesebro B, Jeffrey M. Getting a grip on prions: oligomers, amyloids, and pathological membrane interactions. Annual Review of Biochemistry. 78: 177-204. PMID 19231987 DOI: 10.1146/Annurev.Biochem.78.082907.145410 |
0.343 |
|
| 2009 |
Sim VL, Caughey B. Ultrastructures and strain comparison of under-glycosylated scrapie prion fibrils. Neurobiology of Aging. 30: 2031-42. PMID 18394757 DOI: 10.1016/j.neurobiolaging.2008.02.016 |
0.306 |
|
| 2007 |
Atarashi R, Moore RA, Sim VL, Hughson AG, Dorward DW, Onwubiko HA, Priola SA, Caughey B. Ultrasensitive detection of scrapie prion protein using seeded conversion of recombinant prion protein. Nature Methods. 4: 645-50. PMID 17643109 DOI: 10.1038/Nmeth1066 |
0.305 |
|
| 2006 |
DeMarco ML, Silveira J, Caughey B, Daggett V. Structural properties of prion protein protofibrils and fibrils: an experimental assessment of atomic models. Biochemistry. 45: 15573-82. PMID 17176078 DOI: 10.1021/Bi0612723 |
0.462 |
|
| 2005 |
Silveira JR, Raymond GJ, Hughson AG, Race RE, Sim VL, Hayes SF, Caughey B. The most infectious prion protein particles. Nature. 437: 257-61. PMID 16148934 DOI: 10.1038/nature03989 |
0.33 |
|
| 2005 |
Chesebro B, Trifilo M, Race R, Meade-White K, Teng C, LaCasse R, Raymond L, Favara C, Baron G, Priola S, Caughey B, Masliah E, Oldstone M. Anchorless prion protein results in infectious amyloid disease without clinical scrapie. Science (New York, N.Y.). 308: 1435-9. PMID 15933194 DOI: 10.1126/Science.1110837 |
0.309 |
|
| 2003 |
Caughey B, Lansbury PT. Protofibrils, pores, fibrils, and neurodegeneration: separating the responsible protein aggregates from the innocent bystanders. Annual Review of Neuroscience. 26: 267-98. PMID 12704221 DOI: 10.1146/Annurev.Neuro.26.010302.081142 |
0.358 |
|
| 2002 |
Caughey B, Baron GS. Factors affecting interactions between prion protein isoforms. Biochemical Society Transactions. 30: 565-9. PMID 12196138 DOI: 10.1042/ |
0.325 |
|
| 2001 |
Xiong LW, Raymond LD, Hayes SF, Raymond GJ, Caughey B. Conformational change, aggregation and fibril formation induced by detergent treatments of cellular prion protein. Journal of Neurochemistry. 79: 669-78. PMID 11701770 DOI: 10.1046/j.1471-4159.2001.00606.x |
0.335 |
|
| 2001 |
Callahan MA, Xiong L, Caughey B. Reversibility of scrapie-associated prion protein aggregation. The Journal of Biological Chemistry. 276: 28022-8. PMID 11375994 DOI: 10.1074/jbc.M103629200 |
0.329 |
|
| 2001 |
Horiuchi M, Baron GS, Xiong LW, Caughey B. Inhibition of interactions and interconversions of prion protein isoforms by peptide fragments from the C-terminal folded domain. The Journal of Biological Chemistry. 276: 15489-97. PMID 11279046 DOI: 10.1074/jbc.M100288200 |
0.357 |
|
| 2001 |
Caughey B, Pepys MB, Kelly JW, Ellis RJ, Collinge J, Perutz MF, Masel J. Prion protein interconversions Philosophical Transactions of the Royal Society B: Biological Sciences. 356: 197-202. PMID 11260800 DOI: 10.1098/rstb.2000.0765 |
0.301 |
|
| 2000 |
Horiuchi M, Priola SA, Chabry J, Caughey B. Interactions between heterologous forms of prion protein: binding, inhibition of conversion, and species barriers. Proceedings of the National Academy of Sciences of the United States of America. 97: 5836-41. PMID 10811921 DOI: 10.1073/Pnas.110523897 |
0.301 |
|
| 1999 |
Horiuchi M, Caughey B. Prion protein interconversions and the transmissible spongiform encephalopathies. Structure (London, England : 1993). 7: R231-40. PMID 10545332 DOI: 10.1016/S0969-2126(00)80049-0 |
0.301 |
|
| 1998 |
Caughey WS, Raymond LD, Horiuchi M, Caughey B. Inhibition of protease-resistant prion protein formation by porphyrins and phthalocyanines. Proceedings of the National Academy of Sciences of the United States of America. 95: 12117-22. PMID 9770449 DOI: 10.1073/pnas.95.21.12117 |
0.314 |
|
| 1998 |
Weber DJ, McFadden PN, Caughey B. Measurement of altered aspartyl residues in the scrapie associated form of prion protein Biochemical and Biophysical Research Communications. 246: 606-608. PMID 9618258 DOI: 10.1006/Bbrc.1998.8672 |
0.304 |
|
| 1998 |
Chabry J, Caughey B, Chesebro B. Specific inhibition of in vitro formation of protease-resistant prion protein by synthetic peptides. The Journal of Biological Chemistry. 273: 13203-7. PMID 9582363 DOI: 10.1074/Jbc.273.21.13203 |
0.34 |
|
| 1997 |
DebBurman SK, Raymond GJ, Caughey B, Lindquist S. Chaperone-supervised conversion of prion protein to its protease-resistant form. Proceedings of the National Academy of Sciences of the United States of America. 94: 13938-43. PMID 9391131 DOI: 10.1073/pnas.94.25.13938 |
0.324 |
|
| 1997 |
Bessen RA, Raymond GJ, Caughey B. In situ formation of protease-resistant prion protein in transmissible spongiform encephalopathy-infected brain slices. The Journal of Biological Chemistry. 272: 15227-31. PMID 9182546 DOI: 10.1074/jbc.272.24.15227 |
0.322 |
|
| 1995 |
Priola SA, Caughey B. Inhibition of scrapie-associated PrP accumulation. Probing the role of glycosaminoglycans in amyloidogenesis. Molecular Neurobiology. 8: 113-20. PMID 7999307 DOI: 10.1007/Bf02780661 |
0.345 |
|
| 1995 |
Priola SA, Caughey B, Wehrly K, Chesebro B. A 60-kDa prion protein (PrP) with properties of both the normal and scrapie-associated forms of PrP. The Journal of Biological Chemistry. 270: 3299-305. PMID 7852415 DOI: 10.1074/Jbc.270.7.3299 |
0.351 |
|
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