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Ami S. Lakdawala, Ph.D. - Publications

Affiliations: 
Emory University, Atlanta, GA 
Area:
Medicinal, Bioorganic, Synthetic Organic, Computational
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21 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2019 Haffner CD, Charnley AK, Aquino CJ, Casillas L, Convery MA, Cox JA, Elban MA, Goodwin NC, Gough PJ, Haile PA, Hughes TV, Knapp-Reed B, Kreatsoulas C, Lakdawala AS, Li H, et al. Discovery of Pyrazolocarboxamides as Potent and Selective Receptor Interacting Protein 2 (RIP2) Kinase Inhibitors. Acs Medicinal Chemistry Letters. 10: 1518-1523. PMID 31749904 DOI: 10.1021/Acsmedchemlett.9B00141  0.358
2019 Heightman TD, Callahan J, Chiarparin E, Coyle JE, Griffiths-Jones CM, Lakdawala AS, McMenamin R, Mortenson PN, Norton D, Peakman T, Rich SJ, Richardson C, Rumsey WL, Sanchez Y, Saxty G, et al. Structure-Activity and Structure-Conformation Relationships of Aryl Propionic Acid Inhibitors of the Kelch-like ECH-associated protein 1 : Nuclear factor erythroid 2-related factor 2 (KEAP1:NRF2) protein-protein interaction. Journal of Medicinal Chemistry. PMID 30973731 DOI: 10.1021/Acs.Jmedchem.9B00279  0.395
2018 Kerns JK, Busch-Petersen J, Fu W, Boehm JC, Nie H, Muratore M, Bullion A, Lin G, Li H, Davis R, Lin X, Lakdawala AS, Cousins R, Field R, Payne J, et al. 3,5-Disubstituted-indole-7-carboxamides as IKKβ Inhibitors: Optimization of Oral Activity via the C3 Substituent. Acs Medicinal Chemistry Letters. 9: 1164-1169. PMID 30613320 DOI: 10.1021/Acsmedchemlett.8B00291  0.317
2018 Haile PA, Casillas LN, Bury MJ, Mehlmann JF, Singhaus R, Charnley AK, Hughes TV, DeMartino MP, Wang GZ, Romano JJ, Dong X, Plotnikov NV, Lakdawala AS, Convery MA, Votta BJ, et al. Identification of Quinoline-Based RIP2 Kinase Inhibitors with an Improved Therapeutic Index to the hERG Ion Channel. Acs Medicinal Chemistry Letters. 9: 1039-1044. PMID 30344914 DOI: 10.2210/Pdb6Hmx/Pdb  0.348
2016 Haile PA, Votta BJ, Marquis RW, Bury MJ, Mehlmann JF, Singhaus RR, Charnley AK, Lakdawala AS, Convery MA, Lipshutz DB, Desai BM, Swift B, Capriotti CA, Berger SB, Mahajan MK, et al. The identification and pharmacological characterization of 6-(tert-butylsulfonyl)-N-(5-fluoro-1H-indazol-3-yl)quinolin-4-amine (GSK'583), a highly potent and selective inhibitor of RIP2 Kinase. Journal of Medicinal Chemistry. PMID 27109867 DOI: 10.1021/Acs.Jmedchem.6B00211  0.328
2016 Harris PA, King BW, Bandyopadhyay D, Berger SB, Campobasso N, Capriotti CA, Cox JA, Dare L, Dong X, Finger JN, Grady LC, Hoffman SJ, Jeong JU, Kang J, Kasparcova V, ... Lakdawala AS, et al. DNA-encoded library screening identifies benzo[b][1,4]oxazepin-4-ones as highly potent and mono-selective receptor interacting protein 1 (RIP1) kinase inhibitors. Journal of Medicinal Chemistry. PMID 26854747 DOI: 10.1021/Acs.Jmedchem.5B01898  0.373
2014 Mandal P, Berger SB, Pillay S, Moriwaki K, Huang C, Guo H, Lich JD, Finger J, Kasparcova V, Votta B, Ouellette M, King BW, Wisnoski D, Lakdawala AS, DeMartino MP, et al. RIP3 induces apoptosis independent of pronecrotic kinase activity. Molecular Cell. 56: 481-95. PMID 25459880 DOI: 10.1016/J.Molcel.2014.10.021  0.322
2012 Bakan A, Nevins N, Lakdawala AS, Bahar I. Druggability Assessment of Allosteric Proteins by Dynamics Simulations in the Presence of Probe Molecules. Journal of Chemical Theory and Computation. 8: 2435-2447. PMID 22798729 DOI: 10.1016/J.Bpj.2012.11.3081  0.387
2008 Liu P, Ni R, Mehta AK, Childers WS, Lakdawala A, Pingali SV, Thiyagarajan P, Lynn DG. Nucleobase-directed amyloid nanotube assembly. Journal of the American Chemical Society. 130: 16867-9. PMID 19053426 DOI: 10.1021/Ja807425H  0.312
2007 Ganesh T, Yang C, Norris A, Glass T, Bane S, Ravindra R, Banerjee A, Metaferia B, Thomas SL, Giannakakou P, Alcaraz AA, Lakdawala AS, Snyder JP, Kingston DG. Evaluation of the tubulin-bound paclitaxel conformation: synthesis, biology, and SAR studies of C-4 to C-3' bridged paclitaxel analogues. Journal of Medicinal Chemistry. 50: 713-25. PMID 17263521 DOI: 10.1021/Jm061071X  0.546
2006 Dong J, Lu K, Lakdawala A, Mehta AK, Lynn DG. Controlling amyloid growth in multiple dimensions. Amyloid : the International Journal of Experimental and Clinical Investigation : the Official Journal of the International Society of Amyloidosis. 13: 206-15. PMID 17107881 DOI: 10.1080/13506120600960809  0.341
2005 Liu C, Tamm M, Nötzel MW, Rauch K, De Meijere A, Schilling JK, Lakdawala A, Snyder JP, Bane SL, Shanker N, Ravindra R, Kingston DGI. C-3′-cyclopropanated taxol analogs: Synthesis, bioassay and biostructural analysis European Journal of Organic Chemistry. 3962-3972. DOI: 10.1002/Ejoc.200500243  0.335
2004 Ganesh T, Guza RC, Bane S, Ravindra R, Shanker N, Lakdawala AS, Snyder JP, Kingston DG. The bioactive Taxol conformation on beta-tubulin: experimental evidence from highly active constrained analogs. Proceedings of the National Academy of Sciences of the United States of America. 101: 10006-11. PMID 15226503 DOI: 10.1073/Pnas.0403459101  0.368
2004 Plemper RK, Erlandson KJ, Lakdawala AS, Sun A, Prussia A, Boonsombat J, Aki-Sener E, Yalcin I, Yildiz I, Temiz-Arpaci O, Tekiner B, Liotta DC, Snyder JP, Compans RW. A target site for template-based design of measles virus entry inhibitors Proceedings of the National Academy of Sciences of the United States of America. 101: 5628-5633. PMID 15056763 DOI: 10.1073/Pnas.0308520101  0.578
2003 Plemper RK, Lakdawala AS, Gernert KM, Snyder JP, Compans RW. Structural features of paramyxovirus F protein required for fusion initiation. Biochemistry. 42: 6645-55. PMID 12779319 DOI: 10.1021/Bi034385K  0.323
2003 Lynn DG, Snyder JP, Lakdawala AS, Dong J, Lu K. Conformational evolution: the wiggling of peptides into amyloid. Structure (London, England : 1993). 11: 242. PMID 12623011 DOI: 10.1016/S0969-2126(03)00035-2  0.314
2002 Lakdawala AS, Morgan DM, Liotta DC, Lynn DG, Snyder JP. Dynamics and fluidity of amyloid fibrils: a model of fibrous protein aggregates. Journal of the American Chemical Society. 124: 15150-1. PMID 12487571 DOI: 10.1021/Ja0273290  0.469
2002 Morgan DM, Lynn DG, Lakdawala AS, Snyder JP, Liotta DC. Amyloid structure: Models and theoretical considerations in fibrous aggregates Journal of the Chinese Chemical Society. 49: 459-466. DOI: 10.1002/Jccs.200200072  0.478
2001 Lakdawala A, Wang M, Nevins N, Liotta DC, Rusinska-Roszak D, Lozynski M, Snyder JP. Calculated conformer energies for organic molecules with multiple polar functionalities are method dependent: Taxol (case study). Bmc Chemical Biology. 1: 2. PMID 11710970 DOI: 10.1186/1472-6769-1-2  0.49
2001 Metaferia BB, Hoch J, Glass TE, Bane SL, Chatterjee SK, Snyder JP, Lakdawala A, Cornett B, Kingston DG. Synthesis and biological evaluation of novel macrocyclic paclitaxel analogues. Organic Letters. 3: 2461-4. PMID 11483035 DOI: 10.1021/Ol016124D  0.354
2001 Lakdawala A, Wang M, Nevins N, Liotta DC, Rusinska-Roszak D, Lozynski M, Snyder JP. Calculated conformer energies for organic molecules with multiple polar functionalities are method dependent: Taxol (case study) Bmc Chemical Biology. 1: 1-8. DOI: 10.1186/1472-6769-1-1  0.383
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