| Year |
Citation |
Score |
| 2020 |
Harrington BS, Ozaki MK, Caminear MW, Hernandez LF, Jordan E, Kalinowski NJ, Goldlust IS, Guha R, Ferrer M, Thomas C, Shetty J, Tran B, Wong N, House CD, Annunziata CM. Drugs Targeting Tumor-Initiating Cells Prolong Survival in a Post-Surgery, Post-Chemotherapy Ovarian Cancer Relapse Model. Cancers. 12. PMID 32575908 DOI: 10.3390/Cancers12061645 |
0.329 |
|
| 2020 |
Wei D, Yang Y, Ricketts CJ, Vocke CD, Ball M, Sourbier C, Wangsa D, Wangsa D, Guha R, Zhang X, Wilson K, Chen L, Meltzer PS, Ried T, Thomas CJ, et al. Novel renal medullary carcinoma cell lines, UOK353 and UOK360, provide preclinical tools to identify new therapeutic treatments. Genes, Chromosomes & Cancer. PMID 32259323 DOI: 10.1002/Gcc.22847 |
0.331 |
|
| 2019 |
Lin GL, Wilson KM, Ceribelli M, Stanton BZ, Woo PJ, Kreimer S, Qin EY, Zhang X, Lennon J, Nagaraja S, Morris PJ, Quezada M, Gillespie SM, Duveau DY, Michalowski AM, ... ... Guha R, et al. Therapeutic strategies for diffuse midline glioma from high-throughput combination drug screening. Science Translational Medicine. 11. PMID 31748226 DOI: 10.1126/Scitranslmed.Aaw0064 |
0.354 |
|
| 2019 |
Bandyopadhyay D, Kreatsoulas C, Brady PG, Boyer JG, He Z, Scavello G, Peryea T, Jadhav A, Nguyen DT, Guha R. Scaffold-Based Analytics: Enabling Hit-to-Lead Decisions by Visualizing Chemical Series Linked Across Large Datasets. Journal of Chemical Information and Modeling. PMID 31532656 DOI: 10.1021/Acs.Jcim.9B00243 |
0.301 |
|
| 2019 |
Lee TD, Lee OW, Brimacombe KR, Chen L, Guha R, Lusvarghi S, Tebase BG, Klumpp-Thomas C, Robey RW, Ambudkar SV, Shen M, Gottesman MM, Hall MD. A High-Throughput Screen of a Library of Therapeutics Identifies Cytotoxic Substrates of P-glycoprotein. Molecular Pharmacology. PMID 31515284 DOI: 10.1124/Mol.119.115964 |
0.317 |
|
| 2019 |
Alkhilaiwi F, Paul S, Zhou D, Zhang X, Wang F, Palechor-Ceron N, Wilson K, Guha R, Ferrer M, Grant N, Thomas C, Schlegel R, Yuan H. High-throughput screening identifies candidate drugs for the treatment of recurrent respiratory papillomatosis. Papillomavirus Research (Amsterdam, Netherlands). 100181. PMID 31446060 DOI: 10.1016/J.Pvr.2019.100181 |
0.325 |
|
| 2019 |
Bian Y, Teper Y, Mathews Greiner LA, Aiken TJ, Shukla V, Guha R, Shinn P, Xin HW, Pflicke H, Powers AS, Li D, Jiang JK, Patel P, Rogers S, Aubé J, et al. Target deconvolution of a multikinase inhibitor with anti-metastatic properties identifies TAOK3 as a key contributor to a cancer stem cell-like phenotype. Molecular Cancer Therapeutics. PMID 31395684 DOI: 10.1158/1535-7163.Mct-18-1011 |
0.335 |
|
| 2019 |
Huang R, Grishagin I, Wang Y, Zhao T, Greene J, Obenauer JC, Ngan D, Nguyen DT, Guha R, Jadhav A, Southall N, Simeonov A, Austin CP. The NCATS BioPlanet - An Integrated Platform for Exploring the Universe of Cellular Signaling Pathways for Toxicology, Systems Biology, and Chemical Genomics. Frontiers in Pharmacology. 10: 445. PMID 31133849 DOI: 10.3389/Fphar.2019.00445 |
0.325 |
|
| 2018 |
Kearney SE, Zahoránszky-Kőhalmi G, Brimacombe KR, Henderson MJ, Lynch C, Zhao T, Wan KK, Itkin Z, Dillon C, Shen M, Cheff DM, Lee TD, Bougie D, Cheng K, Coussens NP, ... ... Guha R, et al. Canvass: A Crowd-Sourced, Natural-Product Screening Library for Exploring Biological Space. Acs Central Science. 4: 1727-1741. PMID 30648156 DOI: 10.1021/Acscentsci.8B00747 |
0.38 |
|
| 2018 |
Iniguez AB, Alexe G, Wang EJ, Roti G, Patel S, Chen L, Kitara S, Conway A, Robichaud AL, Stolte B, Bandopadhayay P, Goodale A, Pantel S, Lee Y, Cheff DM, ... ... Guha R, et al. Resistance to Epigenetic-Targeted Therapy Engenders Tumor Cell Vulnerabilities Associated with Enhancer Remodeling. Cancer Cell. 34: 922-938.e7. PMID 30537514 DOI: 10.1016/J.Ccell.2018.11.005 |
0.333 |
|
| 2018 |
Jansson KH, Tucker JB, Stahl LE, Simmons JK, Fuller C, Beshiri ML, Agarwal S, Fang L, Hynes PG, Alilin AN, Lake R, Abbey YC, Cawley J, Tice CM, Yin J, ... ... Guha R, et al. High-throughput screens identify HSP90 inhibitors as potent therapeutics that target inter-related growth and survival pathways in advanced prostate cancer. Scientific Reports. 8: 17239. PMID 30467317 DOI: 10.1038/S41598-018-35417-0 |
0.374 |
|
| 2018 |
Guenther LM, Dharia NV, Ross L, Saur Conway A, Robichaud AL, Catlett JL, Wechsler C, Frank ES, Goodale AB, Church AJ, Tseng YY, Guha R, McKnight C, Janeway KA, Boehm JS, et al. A combination CDK4/6 and IGF1R inhibitor strategy for Ewing sarcoma. Clinical Cancer Research : An Official Journal of the American Association For Cancer Research. PMID 30397176 DOI: 10.1158/1078-0432.Ccr-18-0372 |
0.338 |
|
| 2018 |
Mason DJ, Eastman RT, Lewis RPI, Stott IP, Guha R, Bender A. Using Machine Learning to Predict Synergistic Antimalarial Compound Combinations With Novel Structures. Frontiers in Pharmacology. 9: 1096. PMID 30333748 DOI: 10.3389/Fphar.2018.01096 |
0.402 |
|
| 2018 |
Dyall J, Nelson EA, DeWald LE, Guha R, Hart BJ, Zhou H, Postnikova E, Logue J, Vargas WM, Gross R, Michelotti J, Deiuliis N, Bennett RS, Crozier I, Holbrook MR, et al. Identification of Combinations of Approved Drugs With Synergistic Activity Against Ebola Virus in Cell Cultures. The Journal of Infectious Diseases. PMID 29939303 DOI: 10.1093/Infdis/Jiy304 |
0.316 |
|
| 2018 |
Ferrer M, Gosline SJC, Stathis M, Zhang X, Guo X, Guha R, Ryman DA, Wallace MR, Kasch-Semenza L, Hao H, Ingersoll R, Mohr D, Thomas C, Verma S, Guinney J, et al. Pharmacological and genomic profiling of neurofibromatosis type 1 plexiform neurofibroma-derived schwann cells. Scientific Data. 5: 180106. PMID 29893754 DOI: 10.1038/Sdata.2018.106 |
0.335 |
|
| 2018 |
Coussens NP, Sittampalam GS, Guha R, Brimacombe K, Grossman A, Chung TDY, Weidner JR, Riss T, Trask OJ, Auld D, Dahlin JL, Devanaryan V, Foley TL, McGee J, Kahl SD, et al. The Assay Guidance Manual: Quantitative Biology and Pharmacology in Preclinical Drug Discovery. Clinical and Translational Science. PMID 29877628 DOI: 10.1111/Cts.12570 |
0.329 |
|
| 2018 |
Jansson KH, Tucker JB, Stahl LE, Simmons JK, Fuller C, Beshiri ML, Agarwal S, Abbey Y, Fang L, Hynes PG, Neil AA, Cawley J, Lake R, Tran C, Tice CM, ... ... Guha R, et al. Abstract B018: A high-throughput screen identifies HSP90 inhibitors as potent therapeutics across multiple clinically representative organoid models of advanced prostate cancer Cancer Research. 78. DOI: 10.1158/1538-7445.Prca2017-B018 |
0.378 |
|
| 2018 |
Guenther LM, Dharia NV, Ross L, Conway AS, Robichaud AL, Church AJ, Guha R, Davis MI, Alexe G, Mora J, Piccioni F, Stegmaier K. Abstract 1629: Targeting resistance mechanisms to CDK4/6 inhibitors in Ewing sarcoma with an IGF1R inhibitor drug combination strategy Cancer Research. 78: 1629-1629. DOI: 10.1158/1538-7445.Am2018-1629 |
0.374 |
|
| 2017 |
Lin Y, Mehta S, Küçük-McGinty H, Turner JP, Vidovic D, Forlin M, Koleti A, Nguyen DT, Jensen LJ, Guha R, Mathias SL, Ursu O, Stathias V, Duan J, Nabizadeh N, et al. Drug target ontology to classify and integrate drug discovery data. Journal of Biomedical Semantics. 8: 50. PMID 29122012 DOI: 10.1186/S13326-017-0161-X |
0.323 |
|
| 2017 |
Willighagen EL, Mayfield JW, Alvarsson J, Berg A, Carlsson L, Jeliazkova N, Kuhn S, Pluskal T, Rojas-Chertó M, Spjuth O, Torrance G, Evelo CT, Guha R, Steinbeck C. The Chemistry Development Kit (CDK) v2.0: atom typing, depiction, molecular formulas, and substructure searching. Journal of Cheminformatics. 9: 33. PMID 29086040 DOI: 10.1186/S13321-017-0220-4 |
0.32 |
|
| 2017 |
Heske CM, Davis MI, Baumgart JT, Wilson KM, Gormally MV, Chen L, Zhang X, Ceribelli M, Duveau D, Guha R, Ferrer M, Arnaldez FI, Ji JJ, Tran HL, Zhang Y, et al. Matrix screen identifies synergistic combination of PARP inhibitors and nicotinamide phosphoribosyltransferase (NAMPT) inhibitors in Ewing sarcoma. Clinical Cancer Research : An Official Journal of the American Association For Cancer Research. PMID 28899971 DOI: 10.1158/1078-0432.Ccr-17-1121 |
0.367 |
|
| 2017 |
Jansson KH, Tucker J, Stahl L, Fuller C, Beshiri M, Simmons JK, Agarwal S, Fang L, Alilin AN, Lake R, Tran C, Hynes PG, Cawley J, Yin J, Zhang X, ... Guha R, et al. Abstract 3065: High-throughput screen identifies HSP90 as a potential therapeutic target in models of advanced CRPC Cancer Research. 77: 3065-3065. DOI: 10.1158/1538-7445.Am2017-3065 |
0.334 |
|
| 2017 |
Krane L, Railkar R, Sanford T, Gibbs B, Sourbier C, Ricketts C, Wei D, Hammerich K, Sidana A, Scroggins B, Guha R, Wilson K, Thomas C, Agarwal PK. MP98-10 UTILITY OF HIGH THROUGHPUT SCREENING IN IDENTIFYING AND REPURPOSING SMALL MOLECULE INHIBITORS FOR UROTHELIAL CARCINOMA Journal of Urology. 197. DOI: 10.1016/J.Juro.2017.02.3075 |
0.303 |
|
| 2016 |
Mathews Griner LA, Zhang X, Guha R, McKnight C, Goldlust IS, Lal-Nag M, Wilson K, Michael S, Titus S, Shinn P, Thomas CJ, Ferrer M. Large-scale pharmacological profiling of 3D tumor models of cancer cells. Cell Death & Disease. 7: e2492. PMID 27906188 DOI: 10.1038/Cddis.2016.360 |
0.36 |
|
| 2016 |
Chen L, Wilson K, Goldlust I, Mott BT, Eastman R, Davis MI, Zhang X, McKnight C, Klumpp-Thomas C, Shinn P, Simmons J, Gormally M, Michael S, Thomas CJ, Ferrer M, ... Guha R, et al. mQC: A Heuristic Quality-Control Metric for High-Throughput Drug Combination Screening. Scientific Reports. 6: 37741. PMID 27883049 DOI: 10.1038/Srep37741 |
0.342 |
|
| 2016 |
Ceribelli M, Hou ZE, Kelly PN, Huang DW, Wright G, Ganapathi K, Evbuomwan MO, Pittaluga S, Shaffer AL, Marcucci G, Forman SJ, Xiao W, Guha R, Zhang X, Ferrer M, et al. A Druggable TCF4- and BRD4-Dependent Transcriptional Network Sustains Malignancy in Blastic Plasmacytoid Dendritic Cell Neoplasm. Cancer Cell. 30: 764-778. PMID 27846392 DOI: 10.1182/Blood.V128.22.1513.1513 |
0.303 |
|
| 2016 |
Antignani A, Mathews Griner L, Guha R, Simon N, Pasetto M, Keller J, Huang M, Angelus E, Pastan I, Ferrer M, FitzGerald DJ, Thomas CJ. Chemical Screens Identify Drugs that Enhance or Mitigate Cellular Responses to Antibody-Toxin Fusion Proteins. Plos One. 11: e0161415. PMID 27556570 DOI: 10.1371/Journal.Pone.0161415 |
0.379 |
|
| 2016 |
Van Voorhis WC, Adams JH, Adelfio R, Ahyong V, Akabas MH, Alano P, Alday A, Alemán Resto Y, Alsibaee A, Alzualde A, Andrews KT, Avery SV, Avery VM, Ayong L, Baker M, ... ... Guha R, et al. Open Source Drug Discovery with the Malaria Box Compound Collection for Neglected Diseases and Beyond. Plos Pathogens. 12: e1005763. PMID 27467575 DOI: 10.1371/Journal.Ppat.1005763 |
0.389 |
|
| 2016 |
Anantpadma M, Kouznetsova J, Wang H, Huang R, Kolokoltsov A, Guha R, Lindstrom AR, Shtanko O, Simeonov A, Maloney DJ, Maury W, LaCount DJ, Jadhav A, Davey RA. Large Scale Screening and Identification of Novel Ebolavirus and Marburgvirus Entry Inhibitors. Antimicrobial Agents and Chemotherapy. PMID 27161622 DOI: 10.1128/Aac.00543-16 |
0.352 |
|
| 2016 |
Guha R, Mathews Griner LA, Keller JM, Zhang X, Fitzgerald D, Antignani A, Pastan I, Thomas CJ, Ferrer M. Ranking Differential Drug Activities from Dose-Response Synthetic Lethality Screens. Journal of Biomolecular Screening. PMID 27112173 DOI: 10.1177/1087057116644890 |
0.354 |
|
| 2016 |
Ju W, Zhang M, Wilson KM, Petrus MN, Bamford RN, Zhang X, Guha R, Ferrer M, Thomas CJ, Waldmann TA. Augmented efficacy of brentuximab vedotin combined with ruxolitinib and/or Navitoclax in a murine model of human Hodgkin's lymphoma. Proceedings of the National Academy of Sciences of the United States of America. PMID 26811457 DOI: 10.1073/Pnas.1524668113 |
0.326 |
|
| 2016 |
Heske C, Davis MI, Baumgart JT, Wilson K, Gormally MV, Zhang X, Duveau DY, Guha R, Ferrer M, Mendoza A, Thomas CJ, Helman LJ. Assessing the activity of combining PARP inhibitors (PARPi) and Nicotinamide phosphoribosyltransferase inhibitors (NAMPTi) in Ewing sarcoma (ES). Journal of Clinical Oncology. 34: 11022-11022. DOI: 10.1200/Jco.2016.34.15_Suppl.11022 |
0.315 |
|
| 2016 |
Gryder BE, Yohe ME, Shern J, Chou H, Song Y, Patidar R, Li S, Sindiri S, Cleveland A, Liao H, Wen X, Zhang X, Mathews-Griner L, Guha R, Shinn P, et al. Abstract PR16: Targeting the chromatin architecture established by PAX3-FOXO1 in rhabdomyosarcoma Cancer Research. 76. DOI: 10.1158/1538-7445.Pedca15-Pr16 |
0.325 |
|
| 2016 |
Bogen D, Wei JS, Azorsa DO, Ormanoglu P, Buehler E, Guha R, Keller JM, Griner LAM, Ferrer M, Song YK, Liao H, Mendoza A, Gryder BE, Sindri S, He J, et al. Abstract B31: Combined siRNA and small molecule screening identifies Aurora B kinase as an effective target in MYCN-driven neuroblastoma Cancer Research. 76. DOI: 10.1158/1538-7445.Pedca15-B31 |
0.37 |
|
| 2016 |
Jansson KH, Simmons JK, Fuller C, Agarwal S, Hynes PG, Fang L, Lake R, Cawley J, Stahl L, Zhang X, Guha R, Thomas C, Kelly K. Abstract LB-281: Elucidating potential therapeutic targets in a model of Pten/Tp53 null prostate cancer using high-throughput screening technology Cancer Research. 76. DOI: 10.1158/1538-7445.Am2016-Lb-281 |
0.362 |
|
| 2016 |
Railkar R, Nair A, Lewi K, Krane S, Guha R, Ferrer M, Thomas C, Agarwal PK. Abstract 3758: Quantitative high-throughput screening as a tool to identify novel therapies in bladder cancer: lessons from flavopiridol Cancer Research. 76: 3758-3758. DOI: 10.1158/1538-7445.Am2016-3758 |
0.375 |
|
| 2016 |
Goldlust IS, Wilson K, Szabova L, Zhang X, Mathews-Griner L, Vias M, Piskorz A, Stark R, Mendil L, Kasbekar M, Braisted J, Guha R, McKnight C, Shinn P, Michelle-Smith D, et al. Abstract 278: No cell left behind: Residual ovarian spheroids drive recurrence and are sensitive to the pro-oxidant elesclomol Cancer Research. 76: 278-278. DOI: 10.1158/1538-7445.Am2016-278 |
0.337 |
|
| 2015 |
Bogen D, Wei JS, Azorsa DO, Ormanoglu P, Buehler E, Guha R, Keller JM, Mathews Griner LA, Ferrer M, Song YK, Liao H, Mendoza A, Gryder BE, Sindri S, He J, et al. Aurora B kinase is a potent and selective target in MYCN-driven neuroblastoma. Oncotarget. PMID 26497213 DOI: 10.18632/Oncotarget.6208 |
0.363 |
|
| 2015 |
Cheng KC, Cao S, Raveh A, MacArthur R, Dranchak P, Chlipala G, Okoneski MT, Guha R, Eastman RT, Yuan J, Schultz PJ, Su XZ, Tamayo-Castillo G, Matainaho T, Clardy J, et al. Actinoramide A Identified as a Potent Antimalarial from Titration-Based Screening of Marine Natural Product Extracts. Journal of Natural Products. PMID 26465675 DOI: 10.1021/Acs.Jnatprod.5B00489 |
0.332 |
|
| 2015 |
Mott BT, Eastman RT, Guha R, Sherlach KS, Siriwardana A, Shinn P, McKnight C, Michael S, Lacerda-Queiroz N, Patel PR, Khine P, Sun H, Kasbekar M, Aghdam N, Fontaine SD, et al. High-throughput matrix screening identifies synergistic and antagonistic antimalarial drug combinations. Scientific Reports. 5: 13891. PMID 26403635 DOI: 10.1038/Srep13891 |
0.341 |
|
| 2015 |
Zhang M, Mathews Griner LA, Ju W, Duveau DY, Guha R, Petrus MN, Wen B, Maeda M, Shinn P, Ferrer M, Conlon KD, Bamford RN, O'Shea JJ, Thomas CJ, Waldmann TA. Selective targeting of JAK/STAT signaling is potentiated by Bcl-xL blockade in IL-2-dependent adult T-cell leukemia. Proceedings of the National Academy of Sciences of the United States of America. 112: 12480-5. PMID 26396258 DOI: 10.1073/Pnas.1516208112 |
0.323 |
|
| 2015 |
Bulusu KC, Guha R, Mason DJ, Lewis RP, Muratov E, Kalantar Motamedi Y, Cokol M, Bender A. Modelling of compound combination effects and applications to efficacy and toxicity: state-of-the-art, challenges and perspectives. Drug Discovery Today. PMID 26360051 DOI: 10.1016/J.Drudis.2015.09.003 |
0.356 |
|
| 2015 |
Lewis R, Guha R, Korcsmaros T, Bender A. Synergy Maps: exploring compound combinations using network-based visualization. Journal of Cheminformatics. 7: 36. PMID 26236402 DOI: 10.1186/S13321-015-0090-6 |
0.348 |
|
| 2015 |
Lee JA, Shinn P, Jaken S, Oliver S, Willard FS, Heidler S, Peery RB, Oler J, Chu S, Southall N, Dexheimer TS, Smallwood J, Huang R, Guha R, Jadhav A, et al. Novel Phenotypic Outcomes Identified for a Public Collection of Approved Drugs from a Publicly Accessible Panel of Assays. Plos One. 10: e0130796. PMID 26177200 DOI: 10.1371/Journal.Pone.0130796 |
0.368 |
|
| 2015 |
Pasetto M, Antignani A, Ormanoglu P, Buehler E, Guha R, Pastan I, Martin SE, FitzGerald DJ. Whole-genome RNAi screen highlights components of the endoplasmic reticulum/Golgi as a source of resistance to immunotoxin-mediated cytotoxicity. Proceedings of the National Academy of Sciences of the United States of America. 112: E1135-42. PMID 25713356 DOI: 10.1073/Pnas.1501958112 |
0.319 |
|
| 2015 |
Hasson SA, Fogel AI, Wang C, MacArthur R, Guha R, Heman-Ackah S, Martin S, Youle RJ, Inglese J. Chemogenomic profiling of endogenous PARK2 expression using a genome-edited coincidence reporter. Acs Chemical Biology. 10: 1188-97. PMID 25689131 DOI: 10.1021/Cb5010417 |
0.359 |
|
| 2015 |
Howe EA, de Souza A, Lahr DL, Chatwin S, Montgomery P, Alexander BR, Nguyen DT, Cruz Y, Stonich DA, Walzer G, Rose JT, Picard SC, Liu Z, Rose JN, Xiang X, ... ... Guha R, et al. BioAssay Research Database (BARD): chemical biology and probe-development enabled by structured metadata and result types. Nucleic Acids Research. 43: D1163-70. PMID 25477388 DOI: 10.1093/Nar/Gku1244 |
0.321 |
|
| 2015 |
Zhang M, Griner LAM, Ju W, Duveau DY, Guha R, Petrus MN, Wen B, Maeda M, Shinn P, Ferrer M, Conlon KD, Bamford RN, O'Shea JJ, Thomas CJ, Waldmann TA. Selective targeting of JAK/STAT signaling is potentiated by Bcl-xL blockade in IL-2-dependent adult T-cell leukemia Proceedings of the National Academy of Sciences of the United States of America. 112: 12480-12485. DOI: 10.1186/1742-4690-12-S1-O42 |
0.305 |
|
| 2015 |
Bunch K, Goldlust I, Thomas C, Hernandez L, Guha R, Annunziata C. Abstract LB-254: High-throughput drug matrix screen with SMAC (second mitochondria-derived activator of caspases)-mimetic birinapant in high-grade serous ovarian cancer cell lines identifies synergism Cancer Research. 75. DOI: 10.1158/1538-7445.Am2015-Lb-254 |
0.368 |
|
| 2014 |
Jossé R, Martin SE, Guha R, Ormanoglu P, Pfister TD, Reaper PM, Barnes CS, Jones J, Charlton P, Pollard JR, Morris J, Doroshow JH, Pommier Y. ATR inhibitors VE-821 and VX-970 sensitize cancer cells to topoisomerase i inhibitors by disabling DNA replication initiation and fork elongation responses. Cancer Research. 74: 6968-79. PMID 25269479 DOI: 10.1158/0008-5472.Can-13-3369 |
0.346 |
|
| 2014 |
Inglese J, Dranchak P, Moran JJ, Jang SW, Srinivasan R, Santiago Y, Zhang L, Guha R, Martinez N, MacArthur R, Cost GJ, Svaren J. Genome editing-enabled HTS assays expand drug target pathways for Charcot-Marie-tooth disease. Acs Chemical Biology. 9: 2594-602. PMID 25188731 DOI: 10.1021/Cb5005492 |
0.33 |
|
| 2014 |
Carver J, Dexheimer TS, Hsu D, Weng MT, Smith JL, Guha R, Jadhav A, Simeonov A, Luo J. A high-throughput assay for small molecule destabilizers of the KRAS oncoprotein. Plos One. 9: e103836. PMID 25093678 DOI: 10.1371/Journal.Pone.0103836 |
0.332 |
|
| 2014 |
Ceribelli M, Kelly PN, Shaffer AL, Wright GW, Xiao W, Yang Y, Mathews Griner LA, Guha R, Shinn P, Keller JM, Liu D, Patel PR, Ferrer M, Joshi S, Nerle S, et al. Blockade of oncogenic IκB kinase activity in diffuse large B-cell lymphoma by bromodomain and extraterminal domain protein inhibitors. Proceedings of the National Academy of Sciences of the United States of America. 111: 11365-70. PMID 25049379 DOI: 10.1073/Pnas.1411701111 |
0.347 |
|
| 2014 |
Guha R, Medina-Franco JL. On the validity versus utility of activity landscapes: are all activity cliffs statistically significant? Journal of Cheminformatics. 6: 11. PMID 24694189 DOI: 10.1186/1758-2946-6-11 |
0.367 |
|
| 2014 |
Mathews Griner LA, Guha R, Shinn P, Young RM, Keller JM, Liu D, Goldlust IS, Yasgar A, McKnight C, Boxer MB, Duveau DY, Jiang JK, Michael S, Mierzwa T, Huang W, et al. High-throughput combinatorial screening identifies drugs that cooperate with ibrutinib to kill activated B-cell-like diffuse large B-cell lymphoma cells. Proceedings of the National Academy of Sciences of the United States of America. 111: 2349-54. PMID 24469833 DOI: 10.1073/Pnas.1311846111 |
0.376 |
|
| 2014 |
de Souza A, Bittker JA, Lahr DL, Brudz S, Chatwin S, Oprea TI, Waller A, Yang JJ, Southall N, Guha R, Schürer SC, Vempati UD, Southern MR, Dawson ES, Clemons PA, et al. An Overview of the Challenges in Designing, Integrating, and Delivering BARD: A Public Chemical-Biology Resource and Query Portal for Multiple Organizations, Locations, and Disciplines. Journal of Biomolecular Screening. 19: 614-627. PMID 24441647 DOI: 10.1177/1087057113517139 |
0.326 |
|
| 2014 |
Jossé R, Martin SE, Guha R, Ormanoglu P, Pfister T, Morris J, Doroshow JH, Pommier Y. Abstract 794: The ATR inhibitor VE-821 in combination with the novel topoisomerase I inhibitor LMP-400 selectively kills cancer cells by disabling DNA replication initiation and fork elongation Cancer Research. 74: 794-794. DOI: 10.1158/1538-7445.Am2014-794 |
0.343 |
|
| 2014 |
Antignani A, Pasetto M, Choo C, Angelus E, Mathews L, Guha R, Shinn P, Ferrer M, Thomas CJ, Pastan I, Fitzgerald DJ. Abstract 2907: Everolimus enhances the cytotoxic action of the immunotoxin, HA22, directed to CD22 on B-cell malignancies Cancer Research. 74: 2907-2907. DOI: 10.1158/1538-7445.Am2014-2907 |
0.31 |
|
| 2013 |
Rhyasen GW, Bolanos L, Fang J, Jerez A, Wunderlich M, Rigolino C, Mathews L, Ferrer M, Southall N, Guha R, Keller J, Thomas C, Beverly LJ, Cortelezzi A, Oliva EN, et al. Targeting IRAK1 as a therapeutic approach for myelodysplastic syndrome. Cancer Cell. 24: 90-104. PMID 23845443 DOI: 10.1016/J.Ccr.2013.05.006 |
0.323 |
|
| 2013 |
Guha R. On exploring structure-activity relationships Methods in Molecular Biology. 993: 81-94. PMID 23568465 DOI: 10.1007/978-1-62703-342-8_6 |
0.303 |
|
| 2013 |
Dranchak P, MacArthur R, Guha R, Zuercher WJ, Drewry DH, Auld DS, Inglese J. Profile of the GSK published protein kinase inhibitor set across ATP-dependent and-independent luciferases: implications for reporter-gene assays. Plos One. 8: e57888. PMID 23505445 DOI: 10.1371/Journal.Pone.0057888 |
0.333 |
|
| 2013 |
Casson L, Howell L, Mathews LA, Ferrer M, Southall N, Guha R, Keller JM, Thomas C, Siskind LJ, Beverly LJ. Inhibition of ceramide metabolism sensitizes human leukemia cells to inhibition of BCL2-like proteins. Plos One. 8: e54525. PMID 23342165 DOI: 10.1371/Journal.Pone.0054525 |
0.358 |
|
| 2013 |
Mathews LA, Guha R, Shinn P, Young RM, Lim K, Keller J, Liu D, Yasgar A, McKnight C, Boxer MB, Duveau DY, Jiang J, Michael S, Mott BT, Patel PR, et al. Abstract 4543: High-throughput combination screening identifies novel drug-drug pairings for a Bruton's tyrosine kinase inhibitor against the ABC subtype of diffuse large B-cell lymphomas. Cancer Research. 73: 4543-4543. DOI: 10.1158/1538-7445.Am2013-4543 |
0.4 |
|
| 2012 |
Guha R, Nguyen DT, Southall N, Jadhav A. Dealing with the Data Deluge: Handling the Multitude Of Chemical Biology Data Sources. Current Protocols in Chemical Biology. 4: 193-209. PMID 26609498 DOI: 10.1002/9780470559277.Ch110262 |
0.303 |
|
| 2012 |
Mott BT, Cheng KC, Guha R, Kommer VP, Williams DL, Vermeire JJ, Cappello M, Maloney DJ, Rai G, Jadhav A, Simeonov A, Inglese J, Posner GH, Thomas CJ. A furoxan-amodiaquine hybrid as a potential therapeutic for three parasitic diseases(). Medchemcomm. 3: 1505-1511. PMID 23205265 DOI: 10.1039/C2Md20238G |
0.307 |
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| 2012 |
Mathews LA, Keller JM, Goodwin BL, Guha R, Shinn P, Mull R, Thomas CJ, de Kluyver RL, Sayers TJ, Ferrer M. A 1536-well quantitative high-throughput screen to identify compounds targeting cancer stem cells. Journal of Biomolecular Screening. 17: 1231-42. PMID 22927676 DOI: 10.1177/1087057112458152 |
0.359 |
|
| 2012 |
Guha R. Exploring uncharted territories: Predicting activity Cliffs in structure-activity landscapes Journal of Chemical Information and Modeling. 52: 2181-2191. PMID 22873578 DOI: 10.1021/Ci300047K |
0.389 |
|
| 2012 |
Lee CY, Johnson RL, Wichterman-Kouznetsova J, Guha R, Ferrer M, Tuzmen P, Martin SE, Zhu W, DePamphilis ML. High-throughput screening for genes that prevent excess DNA replication in human cells and for molecules that inhibit them. Methods (San Diego, Calif.). 57: 234-48. PMID 22503772 DOI: 10.1016/J.Ymeth.2012.03.031 |
0.318 |
|
| 2012 |
Heidebrecht RW, Mulrooney C, Austin CP, Barker RH, Beaudoin JA, Cheng KC, Comer E, Dandapani S, Dick J, Duvall JR, Ekland EH, Fidock DA, Fitzgerald ME, Foley M, Guha R, et al. Diversity-Oriented Synthesis Yields a Novel Lead for the Treatment of Malaria. Acs Medicinal Chemistry Letters. 3: 112-117. PMID 22328964 DOI: 10.1021/Ml200244K |
0.332 |
|
| 2011 |
Martin SE, Wu ZH, Gehlhaus K, Jones TL, Zhang YW, Guha R, Miyamoto S, Pommier Y, Caplen NJ. RNAi screening identifies TAK1 as a potential target for the enhanced efficacy of topoisomerase inhibitors. Current Cancer Drug Targets. 11: 976-86. PMID 21834757 DOI: 10.2174/156800911797264734 |
0.357 |
|
| 2011 |
Yuan J, Cheng KC, Johnson RL, Huang R, Pattaradilokrat S, Liu A, Guha R, Fidock DA, Inglese J, Wellems TE, Austin CP, Su XZ. Chemical genomic profiling for antimalarial therapies, response signatures, and molecular targets. Science (New York, N.Y.). 333: 724-9. PMID 21817045 DOI: 10.1126/Science.1205216 |
0.341 |
|
| 2011 |
Guha R, Dexheimer TS, Kestranek AN, Jadhav A, Chervenak AM, Ford MG, Simeonov A, Roth GP, Thomas CJ. Exploratory analysis of kinetic solubility measurements of a small molecule library. Bioorganic & Medicinal Chemistry. 19: 4127-34. PMID 21640593 DOI: 10.1016/J.Bmc.2011.05.005 |
0.375 |
|
| 2011 |
Brown LE, Chih-Chien Cheng K, Wei WG, Yuan P, Dai P, Trilles R, Ni F, Yuan J, MacArthur R, Guha R, Johnson RL, Su XZ, Dominguez MM, Snyder JK, Beeler AB, et al. Discovery of new antimalarial chemotypes through chemical methodology and library development. Proceedings of the National Academy of Sciences of the United States of America. 108: 6775-80. PMID 21498685 DOI: 10.1073/Pnas.1017666108 |
0.373 |
|
| 2010 |
Spjuth O, Willighagen EL, Guha R, Eklund M, Wikberg JE. Towards interoperable and reproducible QSAR analyses: Exchange of datasets. Journal of Cheminformatics. 2: 5. PMID 20591161 DOI: 10.1186/1758-2946-2-5 |
0.353 |
|
| 2010 |
Guha R, Gilbert K, Fox G, Pierce M, Wild D, Yuan H. Advances in cheminformatics methodologies and infrastructure to support the data mining of large, heterogeneous chemical datasets. Current Computer-Aided Drug Design. 6: 50-67. PMID 20370695 DOI: 10.2174/157340910790980115 |
0.384 |
|
| 2009 |
Chen B, Wild D, Guha R. PubChem as a source of polypharmacology. Journal of Chemical Information and Modeling. 49: 2044-55. PMID 19708682 DOI: 10.1021/Ci9001876 |
0.336 |
|
| 2009 |
Bajorath J, Peltason L, Wawer M, Guha R, Lajiness MS, Van Drie JH. Navigating structure-activity landscapes. Drug Discovery Today. 14: 698-705. PMID 19410012 DOI: 10.1016/J.Drudis.2009.04.003 |
0.32 |
|
| 2009 |
Singh N, Guha R, Giulianotti MA, Pinilla C, Houghten RA, Medina-Franco JL. Chemoinformatic analysis of combinatorial libraries, drugs, natural products, and molecular libraries small molecule repository. Journal of Chemical Information and Modeling. 49: 1010-24. PMID 19301827 DOI: 10.1021/Ci800426U |
0.34 |
|
| 2008 |
Guha R. On the interpretation and interpretability of quantitative structure-activity relationship models. Journal of Computer-Aided Molecular Design. 22: 857-71. PMID 18784976 DOI: 10.1007/S10822-008-9240-5 |
0.355 |
|
| 2008 |
Guha R, Van Drie JH. Assessing how well a modeling protocol captures a structure-activity landscape. Journal of Chemical Information and Modeling. 48: 1716-28. PMID 18686944 DOI: 10.1021/Ci8001414 |
0.331 |
|
| 2008 |
Guha R, Van Drie JH. Structure--activity landscape index: identifying and quantifying activity cliffs. Journal of Chemical Information and Modeling. 48: 646-58. PMID 18303878 DOI: 10.1021/Ci7004093 |
0.362 |
|
| 2008 |
Guha R, Schürer SC. Utilizing high throughput screening data for predictive toxicology models: protocols and application to MLSCN assays. Journal of Computer-Aided Molecular Design. 22: 367-84. PMID 18283419 DOI: 10.1007/S10822-008-9192-9 |
0.424 |
|
| 2008 |
Guha R. Flexible Web service infrastructure for the development and deployment of predictive models. Journal of Chemical Information and Modeling. 48: 456-64. PMID 18217738 DOI: 10.1021/Ci700188U |
0.326 |
|
| 2008 |
Bradley J, Rosenthal P, Guha R, Mirza K, Gut J. Open Notebook Science – Falcipain-2 Preliminary Results Nature Precedings. 1-1. DOI: 10.1038/Npre.2008.2216.1 |
0.315 |
|
| 2007 |
Wang H, Klinginsmith J, Dong X, Lee AC, Guha R, Wu Y, Crippen GM, Wild DJ. Chemical data mining of the NCI human tumor cell line database. Journal of Chemical Information and Modeling. 47: 2063-76. PMID 17915856 DOI: 10.1021/Ci700141X |
0.348 |
|
| 2007 |
Dutta D, Guha R, Wild D, Chen T. Ensemble feature selection: consistent descriptor subsets for multiple QSAR models. Journal of Chemical Information and Modeling. 47: 989-97. PMID 17407280 DOI: 10.1021/Ci600563W |
0.363 |
|
| 2007 |
Guha R. Chemical informatics functionality in R Journal of Statistical Software. 18: 1-16. DOI: 10.18637/Jss.V018.I05 |
0.316 |
|
| 2006 |
Guha R, Dutta D, Jurs PC, Chen T. Local lazy regression: making use of the neighborhood to improve QSAR predictions. Journal of Chemical Information and Modeling. 46: 1836-47. PMID 16859315 DOI: 10.1021/Ci060064E |
0.573 |
|
| 2006 |
Guha R, Dutta D, Jurs PC, Chen T. R-NN curves: an intuitive approach to outlier detection using a distance based method. Journal of Chemical Information and Modeling. 46: 1713-22. PMID 16859303 DOI: 10.1021/Ci060013H |
0.557 |
|
| 2006 |
Dutta D, Guha R, Jurs PC, Chen T. Scalable partitioning and exploration of chemical spaces using geometric hashing. Journal of Chemical Information and Modeling. 46: 321-33. PMID 16426067 DOI: 10.1021/Ci050403O |
0.559 |
|
| 2005 |
Guha R, Stanton DT, Jurs PC. Interpreting computational neural network quantitative structure-activity relationship models: a detailed interpretation of the weights and biases. Journal of Chemical Information and Modeling. 45: 1109-21. PMID 16045306 DOI: 10.1021/Ci050110V |
0.539 |
|
| 2005 |
Guha R, Jurs PC. Interpreting computational neural network QSAR models: a measure of descriptor importance. Journal of Chemical Information and Modeling. 45: 800-6. PMID 15921469 DOI: 10.1021/Ci050022A |
0.554 |
|
| 2005 |
Guha R, Jurs PC. Determining the validity of a QSAR model--a classification approach. Journal of Chemical Information and Modeling. 45: 65-73. PMID 15667130 DOI: 10.1021/Ci0497511 |
0.576 |
|
| 2004 |
Guha R, Jurs PC. Development of linear, ensemble, and nonlinear models for the prediction and interpretation of the biological activity of a set of PDGFR inhibitors. Journal of Chemical Information and Computer Sciences. 44: 2179-89. PMID 15554688 DOI: 10.1021/Ci049849F |
0.569 |
|
| 2004 |
Guha R, Serra JR, Jurs PC. Generation of QSAR sets with a self-organizing map. Journal of Molecular Graphics & Modelling. 23: 1-14. PMID 15331049 DOI: 10.1016/J.Jmgm.2004.03.003 |
0.717 |
|
| 2004 |
Guha R, Jurs PC. Development of QSAR models to predict and interpret the biological activity of artemisinin analogues. Journal of Chemical Information and Computer Sciences. 44: 1440-9. PMID 15272852 DOI: 10.1021/Ci0499469 |
0.561 |
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