Kenneth E. Huffman, Ph.D. - Publications

Affiliations: 
University of Texas at Dallas, Richardson, TX, United States 
Area:
Biophysical Chemistry of protein-DNA interactions

59 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2024 Kim C, Wang XD, Liu Z, Hao J, Wang S, Li P, Zi Z, Ding Q, Jang S, Kim J, Luo Y, Huffman KE, Pal Choudhuri S, Del Rio S, Cai L, et al. Induced degradation of lineage-specific oncoproteins drives the therapeutic vulnerability of small cell lung cancer to PARP inhibitors. Science Advances. 10: eadh2579. PMID 38241363 DOI: 10.1126/sciadv.adh2579  0.327
2023 Huffman KE, Li LS, Carstens R, Park H, Girard L, Avila K, Wei S, Kollipara R, Timmons B, Sudderth J, Bendris N, Kim J, Villalobos P, Fujimoto J, Schmid S, et al. Glucocorticoid mediated inhibition of LKB1 mutant non-small cell lung cancers. Frontiers in Oncology. 13: 1025443. PMID 37035141 DOI: 10.3389/fonc.2023.1025443  0.301
2021 Cai L, Liu H, Huang F, Fujimoto J, Girard L, Chen J, Li Y, Zhang YA, Deb D, Stastny V, Pozo K, Kuo CS, Jia G, Yang C, Zou W, ... ... Huffman K, et al. Cell-autonomous immune gene expression is repressed in pulmonary neuroendocrine cells and small cell lung cancer. Communications Biology. 4: 314. PMID 33750914 DOI: 10.1038/s42003-021-01842-7  0.307
2020 Tlemsani C, Pongor L, Elloumi F, Girard L, Huffman KE, Roper N, Varma S, Luna A, Rajapakse VN, Sebastian R, Kohn KW, Krushkal J, Aladjem MI, Teicher BA, Meltzer PS, et al. SCLC-CellMiner: A Resource for Small Cell Lung Cancer Cell Line Genomics and Pharmacology Based on Genomic Signatures. Cell Reports. 33: 108296. PMID 33086069 DOI: 10.1016/j.celrep.2020.108296  0.353
2020 Huang F, Huffman K, Wang Z, Wang X, Li K, Cai F, Yang C, Cai L, Shih TS, Zacharias LG, Chung AS, Yang Q, Chalishazar MD, Ireland AS, Stewart CA, et al. Guanosine triphosphate links MYC-dependent metabolic and ribosome programs in small cell lung cancer. The Journal of Clinical Investigation. PMID 33079728 DOI: 10.1172/JCI139929  0.368
2020 Yenerall P, Das A, Wang S, Kollipara R, Li H, Shan Li L, Villalobos P, Flaming J, Huffman K, Timmons B, Gilbreath C, Sonavane R, Rodriguez-Canales J, Moran C, Behrens C, et al. A17 Inhibition of RUVBL1/2 ATPase Activity Drives Immune Infiltration and Radiosensitizes Non-Small Cell Lung Cancer Journal of Thoracic Oncology. 15: S17-S18. DOI: 10.1016/J.Jtho.2019.12.046  0.351
2019 Yenerall P, Das AK, Wang S, Kollipara RK, Li LS, Villalobos P, Flaming J, Lin YF, Huffman K, Timmons BC, Gilbreath C, Sonavane R, Kinch LN, Rodriguez-Canales J, Moran C, et al. RUVBL1/RUVBL2 ATPase Activity Drives PAQosome Maturation, DNA Replication and Radioresistance in Lung Cancer. Cell Chemical Biology. PMID 31883965 DOI: 10.1016/J.Chembiol.2019.12.005  0.447
2019 Chen PH, Cai L, Huffman K, Yang C, Kim J, Faubert B, Boroughs L, Ko B, Sudderth J, McMillan EA, Girard L, Chen D, Peyton M, Shields MD, Yao B, et al. Metabolic Diversity in Human Non-Small Cell Lung Cancer Cells. Molecular Cell. PMID 31564558 DOI: 10.1016/J.Molcel.2019.08.028  0.403
2019 Cai L, Lin S, Girard L, Zhou Y, Yang L, Ci B, Zhou Q, Luo D, Yao B, Tang H, Allen J, Huffman K, Gazdar A, Heymach J, Wistuba I, et al. Correction: LCE: an open web portal to explore gene expression and clinical associations in lung cancer. Oncogene. PMID 31501522 DOI: 10.1038/S41388-019-1000-6  0.353
2019 Wang XD, Hu R, Ding Q, Savage TK, Huffman KE, Williams N, Cobb MH, Minna JD, Johnson JE, Yu Y. Subtype-specific secretomic characterization of pulmonary neuroendocrine tumor cells. Nature Communications. 10: 3201. PMID 31324758 DOI: 10.1038/S41467-019-11153-5  0.423
2019 Kim J, Hu Z, Cai L, Li K, Choi E, Faubert B, Bezwada D, Rodriguez-Canales J, Villalobos P, Lin YF, Ni M, Huffman KE, Girard L, Byers LA, Unsal-Kacmaz K, et al. Author Correction: CPS1 maintains pyrimidine pools and DNA synthesis in KRAS/LKB1-mutant lung cancer cells. Nature. PMID 31043737 DOI: 10.1038/S41586-019-1133-3  0.375
2018 Cai L, Lin S, Girard L, Zhou Y, Yang L, Ci B, Zhou Q, Luo D, Yao B, Tang H, Allen J, Huffman K, Gazdar A, Heymach J, Wistuba I, et al. LCE: an open web portal to explore gene expression and clinical associations in lung cancer. Oncogene. PMID 30532070 DOI: 10.1038/S41388-018-0588-2  0.36
2018 Huang F, Ni M, Chalishazar MD, Huffman KE, Kim J, Cai L, Shi X, Cai F, Zacharias LG, Ireland AS, Li K, Gu W, Kaushik AK, Liu X, Gazdar AF, et al. Inosine Monophosphate Dehydrogenase Dependence in a Subset of Small Cell Lung Cancers. Cell Metabolism. PMID 30043754 DOI: 10.1016/J.Cmet.2018.06.005  0.469
2018 McMillan EA, Ryu MJ, Diep CH, Mendiratta S, Clemenceau JR, Vaden RM, Kim JH, Motoyaji T, Covington KR, Peyton M, Huffman K, Wu X, Girard L, Sung Y, Chen PH, et al. Chemistry-First Approach for Nomination of Personalized Treatment in Lung Cancer. Cell. PMID 29681454 DOI: 10.1016/J.Cell.2018.03.028  0.355
2018 Shimada Y, Okano T, Yenerall P, Huffman K, Timmons B, Gao B, Deb D, Ikeda N, Minna JD. Exosomes secreted from mesenchymal NSCLC cells to promote invasiveness and metastatic capability of recipient cells through UCHL1. Journal of Clinical Oncology. 36: e24008-e24008. DOI: 10.1200/Jco.2018.36.15_Suppl.E24008  0.381
2018 Minna JD, McMillan E, Girard L, Peyton M, Huffman K, Deb D, Yenerall P, Das A, Li L, Dalvi M, Gao B, Xie Y, Yu Y, Hight S, Vaden R, et al. Abstract IA12: Developing precision medicine-based new lung cancer therapeutics Clinical Cancer Research. 24. DOI: 10.1158/1557-3265.Aacriaslc18-Ia12  0.37
2018 Otaki Y, Yenerall P, Gao B, Peyton M, Avila K, Girard L, Li L, Das A, Huffman K, Timmons B, Park H, Deb D, Minna J. P3.03-14 Downregulation of FOXM1 Inhibits Tumor Proliferation, Colony Formation and Spheroid Formation of Non-Small Cell Lung Cancer Journal of Thoracic Oncology. 13: S915-S916. DOI: 10.1016/J.Jtho.2018.08.1691  0.379
2017 Zhao X, Huffman KE, Fujimoto J, Canales JR, Girard L, Nie G, Heymach JV, Wistuba II, Minna JD, Yu Y. Quantitative Proteomic Analysis of Optimal Cutting Temperature (OCT) Embedded Core-Needle Biopsy of Lung Cancer. Journal of the American Society For Mass Spectrometry. PMID 28752479 DOI: 10.1007/S13361-017-1706-Z  0.366
2017 Kim J, Hu Z, Cai L, Li K, Choi E, Faubert B, Bezwada D, Rodriguez-Canales J, Villalobos P, Lin YF, Ni M, Huffman KE, Girard L, Byers LA, Unsal-Kacmaz K, et al. CPS1 maintains pyrimidine pools and DNA synthesis in KRAS/LKB1-mutant lung cancer cells. Nature. PMID 28538732 DOI: 10.1038/Nature22359  0.461
2017 Shimada Y, Yenerall P, Avila K, Park H, Timmons B, Huffman K, Gao B, Deb D, Dalvi M, Minna JD. Abstract 907: Uptake of lung cancer exosomes induces migratory and invasive phenotypic changes in lung epithelial cells in an oncogene context dependent manner Cancer Research. 77: 907-907. DOI: 10.1158/1538-7445.Am2017-907  0.412
2017 Shimada Y, Yenerall P, Huffman K, Avila K, Park H, Timmons B, Gao B, Deb D, Ikeda N, Minna J. MA 15.13 The Transfer of Exogenous UCHL-1 via Mesenchymal Lung Cancer Exosomes to Mediate Phenotypic Alterations of Recipients Journal of Thoracic Oncology. 12: S1865-S1866. DOI: 10.1016/J.Jtho.2017.09.594  0.337
2017 Zhao X, Huffman K, Fujimoto J, Canales J, Girard L, Guangjun N, Heymach J, Wistuba I, Minna J, Yu Y. Quantitative Proteomic Analysis of Core-Needle Biopsy of Lung Cancer Journal of Thoracic Oncology. 12: S1540-S1541. DOI: 10.1016/J.Jtho.2017.06.040  0.32
2016 Gao B, Huang C, Kernstine K, Pelekanou V, Kluger Y, Jiang T, Peters-Hall JR, Coquelin M, Girard L, Zhang W, Huffman K, Oliver D, Kinose F, Haura E, Teer JK, et al. Non-malignant respiratory epithelial cells preferentially proliferate from resected non-small cell lung cancer specimens cultured under conditionally reprogrammed conditions. Oncotarget. PMID 28052041 DOI: 10.18632/Oncotarget.14366  0.351
2016 Yan Y, Liu L, Xiong H, Miller JB, Zhou K, Kos P, Huffman KE, Elkassih S, Norman JW, Carstens R, Kim J, Minna JD, Siegwart DJ. Functional polyesters enable selective siRNA delivery to lung cancer over matched normal cells. Proceedings of the National Academy of Sciences of the United States of America. PMID 27621434 DOI: 10.1073/Pnas.1606886113  0.38
2016 Padanad MS, Konstantinidou G, Venkateswaran N, Melegari M, Rindhe S, Mitsche M, Yang C, Batten K, Huffman KE, Liu J, Tang X, Rodriguez-Canales J, Kalhor N, Shay JW, Minna JD, et al. Fatty Acid Oxidation Mediated by Acyl-CoA Synthetase Long Chain 3 Is Required for Mutant KRAS Lung Tumorigenesis. Cell Reports. PMID 27477280 DOI: 10.1016/J.Celrep.2016.07.009  0.358
2016 Gelsomino L, Gu G, Rechoum Y, Beyer AR, Pejerrey SM, Tsimelzon A, Wang T, Huffman K, Ludlow A, Andò S, Fuqua SA. ESR1 mutations affect anti-proliferative responses to tamoxifen through enhanced cross-talk with IGF signaling. Breast Cancer Research and Treatment. PMID 27178332 DOI: 10.1007/S10549-016-3829-5  0.327
2016 DeNicola GM, Chen PH, Mullarky E, Sudderth JA, Hu Z, Wu D, Tang H, Xie Y, Asara JM, Huffman KE, Wistuba II, Minna JD, DeBerardinis RJ, Cantley LC. Erratum: NRF2 regulates serine biosynthesis in non-small cell lung cancer. Nature Genetics. 48: 473. PMID 27023779 DOI: 10.1038/Ng0329-473A  0.322
2016 Hu R, Huffman KE, Chu M, Zhang Y, Minna JD, Yu Y. Quantitative Secretomic Analysis Identifies Extracellular Protein Factors that Modulate the Metastatic Phenotype of Non-Small Cell Lung Cancer. Journal of Proteome Research. PMID 26736068 DOI: 10.1021/Acs.Jproteome.5B00819  0.421
2016 Padanad MS, Konstantinidou G, Yang C, Melegari M, Venkateswaran N, Batten K, Huffman KE, Shay JW, Minna JD, DeBerardinis RJ, Scaglioni PP. Abstract B22: Acyl-CoA synthetase long-chain family member 3 dependent lipid homeostasis is required for mutant KRAS driven lung cancer Molecular Cancer Research. 14. DOI: 10.1158/1557-3125.Metca15-B22  0.425
2015 Lou TF, Sethuraman D, Dospoy P, Srivastva P, Kim HS, Kim J, Ma X, Chen PH, Huffman KE, Frink RE, Larsen JE, Lewis CM, Um SW, Kim DH, Ahn JM, et al. Cancer-specific production of N-acetylaspartate via NAT8L overexpression in non-small cell lung cancer and its potential as a circulating biomarker. Cancer Prevention Research (Philadelphia, Pa.). PMID 26511490 DOI: 10.1158/1940-6207.Capr-14-0287  0.411
2015 DeNicola GM, Chen PH, Mullarky E, Sudderth JA, Hu Z, Wu D, Tang H, Xie Y, Asara JM, Huffman KE, Wistuba II, Minna JD, DeBerardinis RJ, Cantley LC. NRF2 regulates serine biosynthesis in non-small cell lung cancer. Nature Genetics. PMID 26482881 DOI: 10.1038/Ng.3421  0.448
2015 Elkin SR, Bendris N, Reis C, Zhou Y, Xie Y, Huffman KE, Minna JD, Schmid SL. A systematic analysis reveals heterogeneous changes in the endocytic activities of cancer cells. Cancer Research. PMID 26359453 DOI: 10.1158/0008-5472.Can-15-0939  0.411
2015 Huffman KE, Carstens R, Martinez ED. A Subset of Nuclear Receptors are Uniquely Expressed in Uveal Melanoma Cells. Frontiers in Endocrinology. 6: 93. PMID 26217306 DOI: 10.3389/Fendo.2015.00093  0.411
2015 Gu G, Gelsomino L, Covington KR, Beyer AR, Wang J, Rechoum Y, Huffman K, Carstens R, Andò S, Fuqua SA. Targeting thyroid hormone receptor beta in triple-negative breast cancer. Breast Cancer Research and Treatment. 150: 535-45. PMID 25820519 DOI: 10.1007/S10549-015-3354-Y  0.375
2015 Tian H, Lu JY, Shao C, Huffman KE, Carstens RM, Larsen JE, Girard L, Liu H, Rodriguez-Canales J, Frenkel EP, Wistuba II, Minna JD, Hofmann SL. Systematic siRNA Screen Unmasks NSCLC Growth Dependence by Palmitoyltransferase DHHC5. Molecular Cancer Research : McR. 13: 784-94. PMID 25573953 DOI: 10.1158/1541-7786.Mcr-14-0608  0.426
2015 Yenerall PM, Kollipara R, Carstens R, Huffman K, Girard L, Rodriguez J, Wistuba I, Mangelsdorf D, Minna J, Kittler R. Abstract 4779: RUVBL1 and RUBVL2 are chromatin remodelers that represent prognostic and novel therapeutic targets for a subset of non-small cell lung cancers (NSCLCs) Cancer Research. 75: 4779-4779. DOI: 10.1158/1538-7445.Am2015-4779  0.471
2015 Boroughs LK, Chen P, Cai L, Rodriguez M, Zhang W, Huffman KE, Byers LA, Girard L, Gazdar AF, Heymach JV, White MA, Minna JD, Emberley E, Pan A, Parlati F, et al. Abstract 4710: Evaluation of the glutaminase inhibitor CB-839 in non-small cell lung cancer Cancer Research. 75: 4710-4710. DOI: 10.1158/1538-7445.Am2015-4710  0.429
2015 Tian H, Qi X, Huffman K, Minna J, Hofmann SL. Abstract 3562: Protein palmitoylation in breast cancer: DHHC5 palmitoyltransferase as a potential therapeutic target Cancer Research. 75: 3562-3562. DOI: 10.1158/1538-7445.Am2015-3562  0.413
2014 Srivastava N, Kollipara RK, Singh DK, Sudderth J, Hu Z, Nguyen H, Wang S, Humphries CG, Carstens R, Huffman KE, DeBerardinis RJ, Kittler R. Inhibition of cancer cell proliferation by PPARγ is mediated by a metabolic switch that increases reactive oxygen species levels. Cell Metabolism. 20: 650-61. PMID 25264247 DOI: 10.1016/J.Cmet.2014.08.003  0.378
2014 Tian H, Lu J, Shao C, Huffman K, Carstens R, Minna JD, Hofmann SL. Abstract 4619: Protein palmitoylation in non-small cell lung cancer (NSCLC): DHHC5 palmitoyltransferase as a potential therapeutic target Cancer Research. 74: 4619-4619. DOI: 10.1158/1538-7445.Am2014-4619  0.429
2014 Larsen JE, Davis CF, Huffman K, Girard L, Wheeler DA, Gibbs RA, Minna JD. Abstract 1525: Exome sequencing to identify permissive mutations representing acquired vulnerabilities in lung cancer Cancer Research. 74: 1525-1525. DOI: 10.1158/1538-7445.Am2014-1525  0.365
2014 Minna JD, Gazdar A, Augustyn A, Britt R, Carstens R, Dospoy P, Gao B, Girard L, Hight S, Huffman K, Larsen J, Peyton M, Shao C, Mangelsdorf D, Brekken R, et al. Abstract IA21: Developing a new functional classification of lung cancer based on tumor acquired vulnerabilities. Clinical Cancer Research. 20: IA21-IA21. DOI: 10.1158/1078-0432.14Aacriaslc-Ia21  0.428
2013 Huffman K, Martinez ED. Pre-clinical studies of epigenetic therapies targeting histone modifiers in lung cancer. Frontiers in Oncology. 3: 235. PMID 24058902 DOI: 10.3389/Fonc.2013.00235  0.374
2013 Girard L, Peyton M, Wistuba I, Xie Y, Greer R, Suraokar MB, Behrens C, Xiao G, Heymach J, Wheeler DA, Davis CF, Huffman K, Shames DS, Coombes KR, Gazdar AF, et al. Abstract 5589: Molecular signatures of in vitro drug response in lung cancer. Cancer Research. 73: 5589-5589. DOI: 10.1158/1538-7445.Am2013-5589  0.399
2013 Carstens R, Huffman K, Wei S, Girard L, Xie Y, Hofmann S, Wistuba I, Fuqua S, Posner B, Gazdar AF, Kliewer S, O'Malley B, Mangelsdorf D, Minna JD. Abstract 1474: An RNAi-based functional classification of lung cancer reveals recurring subgroups strongly correlated with EMT status. Cancer Research. 73: 1474-1474. DOI: 10.1158/1538-7445.Am2013-1474  0.449
2013 Augustyn A, Borromeo M, Wang T, Shao C, Dospoy P, Huffman K, Carstens R, Girard L, Behrens C, Wistuba I, Xie Y, Johnson J, Gazdar A, Minna J. Abstract A24: Targeted synthetic lethal screens to identify acquired vulnerabilities in a novel class of ASCL1-dependent neuroendocrine non-small cell lung cancers Molecular Cancer Therapeutics. 12. DOI: 10.1158/1535-7163.Pms-A24  0.474
2012 Rudin CM, Durinck S, Stawiski EW, Poirier JT, Modrusan Z, Shames DS, Bergbower EA, Guan Y, Shin J, Guillory J, Rivers CS, Foo CK, Bhatt D, Stinson J, Gnad F, ... ... Huffman KE, et al. Comprehensive genomic analysis identifies SOX2 as a frequently amplified gene in small-cell lung cancer. Nature Genetics. 44: 1111-6. PMID 22941189 DOI: 10.1038/Ng.2405  0.475
2012 Carstens R, Huffman K, Girard L, Posner B, Erickson H, Wistuba I, Gazdar A, Kliewer S, Fuqua S, O'Malley B, Mangelsdorf D, Minna JD. Abstract 5757: A new functional classification of lung and breast cancers based on siRNA mediated knockdown of 48 NRs and 72 CoRegulators Cancer Research. 72: 5757-5757. DOI: 10.1158/1538-7445.Am2012-5757  0.456
2012 Augustyn A, Tan C, Sullivan JP, Huffman K, Girard L, Borromeo M, Johnson J, Wistuba I, Xie Y, Minna JD. Abstract 1309: The lineage-specific transcription factor ASCL1 defines a subtype of non-small cell lung cancer with poor prognosis Cancer Research. 72: 1309-1309. DOI: 10.1158/1538-7445.Am2012-1309  0.446
2012 Minna JD, Shao C, Das A, Desevo C, Dospoy P, Gao B, Greer R, Hight S, Huffman K, Larsen J, Peyton M, Shields M, Sullivan JP, Sullivan L, Gerber D, et al. Abstract IA3: Lung cancer stem cells, acquired vulnerabilities, and molecular portraits: Translation to the clinic Clinical Cancer Research. 18: IA3-IA3. DOI: 10.1158/1078-0432.12Aacriaslc-Ia3  0.303
2007 Janowski BA, Younger ST, Hardy DB, Ram R, Huffman KE, Corey DR. Activating gene expression in mammalian cells with promoter-targeted duplex RNAs. Nature Chemical Biology. 3: 166-73. PMID 17259978 DOI: 10.1038/Nchembio860  0.746
2006 Janowski BA, Huffman KE, Schwartz JC, Ram R, Nordsell R, Shames DS, Minna JD, Corey DR. Involvement of AGO1 and AGO2 in mammalian transcriptional silencing. Nature Structural & Molecular Biology. 13: 787-92. PMID 16936728 DOI: 10.1038/Nsmb1140  0.74
2005 Janowski BA, Huffman KE, Schwartz JC, Ram R, Hardy D, Shames DS, Minna JD, Corey DR. Inhibiting gene expression at transcription start sites in chromosomal DNA with antigene RNAs. Nature Chemical Biology. 1: 216-22. PMID 16408038 DOI: 10.1038/Nchembio725  0.748
2005 Janowski BA, Kaihatsu K, Huffman KE, Schwartz JC, Ram R, Hardy D, Mendelson CR, Corey DR. Inhibiting transcription of chromosomal DNA with antigene peptide nucleic acids. Nature Chemical Biology. 1: 210-5. PMID 16408037 DOI: 10.1038/Nchembio724  0.72
2005 Huffman KE, Corey DR. Major vault protein does not play a role in chemoresistance or drug localization in a non-small cell lung cancer cell line. Biochemistry. 44: 2253-61. PMID 15709737 DOI: 10.1021/Bi047948G  0.571
2004 Kaihatsu K, Huffman KE, Corey DR. Intracellular uptake and inhibition of gene expression by PNAs and PNA-peptide conjugates. Biochemistry. 43: 14340-7. PMID 15533038 DOI: 10.1021/Bi048519L  0.715
2000 Huffman KE, Levene SD, Tesmer VM, Shay JW, Wright WE. Telomere shortening is proportional to the size of the G-rich telomeric 3'-overhang. The Journal of Biological Chemistry. 275: 19719-22. PMID 10787419 DOI: 10.1074/Jbc.M002843200  0.643
1999 Huffman KE, Levene SD. DNA-sequence asymmetry directs the alignment of recombination sites in the FLP synaptic complex. Journal of Molecular Biology. 286: 1-13. PMID 9931245 DOI: 10.1006/Jmbi.1998.2468  0.626
1997 Wright WE, Tesmer VM, Huffman KE, Levene SD, Shay JW. Normal human chromosomes have long G-rich telomeric overhangs at one end. Genes & Development. 11: 2801-9. PMID 9353250 DOI: 10.1101/Gad.11.21.2801  0.655
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