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Mark E. Lindsay, Ph.D. - Publications

Affiliations: 
University of Virginia, Charlottesville, VA 
Area:
Signal transduction
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40 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2023 Raghavan A, Pirruccello JP, Ellinor PT, Lindsay ME. Using Genomics to Identify Novel Therapeutic Targets for Aortic Disease. Arteriosclerosis, Thrombosis, and Vascular Biology. PMID 38095107 DOI: 10.1161/ATVBAHA.123.318771  0.303
2023 Pirruccello JP, Khurshid S, Lin H, Weng LC, Zamirpour S, Kany S, Raghavan A, Koyama S, Vasan RS, Benjamin EJ, Lindsay ME, Ellinor PT. AORTA Gene: Polygenic prediction improves detection of thoracic aortic aneurysm. Medrxiv : the Preprint Server For Health Sciences. PMID 37662232 DOI: 10.1101/2023.08.23.23294513  0.317
2022 Pirruccello JP, Lin H, Khurshid S, Nekoui M, Weng LC, Ramachandran VS, Isselbacher EM, Benjamin EJ, Lubitz SA, Lindsay ME, Ellinor PT. Development of a Prediction Model for Ascending Aortic Diameter Among Asymptomatic Individuals. Jama. 328: 1935-1944. PMID 36378208 DOI: 10.1001/jama.2022.19701  0.323
2022 Chou E, Pirruccello JP, Ellinor PT, Lindsay ME. Genetics and mechanisms of thoracic aortic disease. Nature Reviews. Cardiology. PMID 36131050 DOI: 10.1038/s41569-022-00763-0  0.318
2022 Ganapathi AM, Ranney DN, Peterson MD, Lindsay ME, Patel HJ, Pyeritz RE, Trimarchi S, Hutchison S, Harris KM, Greason KL, Ota T, Montgomery DG, Nienaber CA, Eagle KA, Isselbacher EM, et al. Location of Aortic Enlargement and Risk of Type A Dissection at Smaller Diameters. Journal of the American College of Cardiology. 79: 1890-1897. PMID 35550685 DOI: 10.1016/j.jacc.2022.02.053  0.316
2020 Chou EL, Lindsay ME. The genetics of aortopathies: Hereditary thoracic aortic aneurysms and dissections. American Journal of Medical Genetics. Part C, Seminars in Medical Genetics. PMID 32034893 DOI: 10.1002/Ajmg.C.31771  0.45
2019 Lin AE, Alali A, Starr LJ, Shah N, Beavis A, Pereira EM, Lindsay ME, Klugman S. Gain-of-function pathogenic variants in SMAD4 are associated with neoplasia in Myhre syndrome. American Journal of Medical Genetics. Part A. PMID 31837202 DOI: 10.1002/Ajmg.A.61430  0.305
2019 Malhotra R, Mauer AC, Lino Cardenas CL, Guo X, Yao J, Zhang X, Wunderer F, Smith AV, Wong Q, Pechlivanis S, Hwang SJ, Wang J, Lu L, Nicholson CJ, Shelton G, ... ... Lindsay ME, et al. HDAC9 is implicated in atherosclerotic aortic calcification and affects vascular smooth muscle cell phenotype. Nature Genetics. PMID 31659325 DOI: 10.1038/S41588-019-0514-8  0.416
2019 Boileau A, Cardenas CLL, Courtois A, Zhang L, Rodosthenous RS, Das S, Sakalihasan N, Michel JB, Lindsay ME, Devaux Y. MiR-574-5p: A Circulating Marker of Thoracic Aortic Aneurysm. International Journal of Molecular Sciences. 20. PMID 31409059 DOI: 10.3390/Ijms20163924  0.306
2019 Duran JM, Naderi S, Vidula M, Michalak N, Chi G, Lindsay M, Ghoshhajra B, Gibson CM, Wood MJ. Spontaneous coronary artery dissection and its association with takotsubo syndrome: Novel insights from a tertiary center registry. Catheterization and Cardiovascular Interventions : Official Journal of the Society For Cardiac Angiography & Interventions. PMID 31037831 DOI: 10.1002/Ccd.28314  0.327
2019 Sharma S, Kaadan MI, Duran JM, Ponzini F, Mishra S, Tsiaras SV, Scott NS, Weinberg I, Ghoshhajra B, Lindsay M, Gibson CM, Chi G, Michalak N, Wood MJ. Risk Factors, Imaging Findings, and Sex Differences in Spontaneous Coronary Artery Dissection. The American Journal of Cardiology. PMID 30929769 DOI: 10.1016/J.Amjcard.2019.02.040  0.305
2019 Lino Cardenas CL, Kessinger CW, Chou E, Ghoshhajra B, Yeri AS, Das S, Weintraub NL, Malhotra R, Jaffer FA, Lindsay ME. HDAC9 complex inhibition improves smooth muscle-dependent stenotic vascular disease. Jci Insight. 4. PMID 30674723 DOI: 10.1172/Jci.Insight.124706  0.404
2019 MacFarlane EG, Parker SJ, Shin JY, Ziegler SG, Creamer TJ, Bagirzadeh R, Bedja D, Chen Y, Calderon JF, Weissler K, Frischmeyer-Guerrerio PA, Lindsay ME, Habashi JP, Dietz HC. Lineage-specific events underlie aortic root aneurysm pathogenesis in Loeys-Dietz syndrome. The Journal of Clinical Investigation. PMID 30614814 DOI: 10.1172/Jci123547  0.427
2018 Gould RA, Aziz H, Woods CE, Seman-Senderos MA, Sparks E, Preuss C, Wünnemann F, Bedja D, Moats CR, McClymont SA, Rose R, Sobreira N, Ling H, MacCarrick G, Kumar AA, ... ... Lindsay ME, et al. ROBO4 variants predispose individuals to bicuspid aortic valve and thoracic aortic aneurysm. Nature Genetics. PMID 30455415 DOI: 10.1038/S41588-018-0265-Y  0.443
2018 Boileau A, Lindsay ME, Michel JB, Devaux Y. Epigenetics in Ascending Thoracic Aortic Aneurysm and Dissection. Aorta (Stamford, Conn.). 6: 1-12. PMID 30079931 DOI: 10.1055/s-0038-1639610  0.353
2018 Renard M, Francis C, Ghosh R, Scott AF, Witmer PD, Adès LC, Andelfinger GU, Arnaud P, Boileau C, Callewaert BL, Guo D, Hanna N, Lindsay ME, Morisaki H, Morisaki T, et al. Clinical Validity of Genes for Heritable Thoracic Aortic Aneurysm and Dissection. Journal of the American College of Cardiology. 72: 605-615. PMID 30071989 DOI: 10.1016/J.Jacc.2018.04.089  0.431
2018 Lindsay ME. Medical management of aortic disease in children with Marfan syndrome. Current Opinion in Pediatrics. PMID 30036202 DOI: 10.1097/Mop.0000000000000671  0.382
2018 Kaadan MI, MacDonald C, Ponzini F, Duran J, Newell K, Pitler L, Lin A, Weinberg I, Wood MJ, Lindsay ME. Prospective Cardiovascular Genetics Evaluation in Spontaneous Coronary Artery Dissection. Circulation. Genomic and Precision Medicine. 11: e001933. PMID 29650765 DOI: 10.1161/Circgenetics.117.001933  0.317
2018 Lino Cardenas CL, Kessinger CW, Cheng Y, MacDonald C, MacGillivray T, Ghoshhajra B, Huleihel L, Nuri S, Yeri AS, Jaffer FA, Kaminski N, Ellinor P, Weintraub NL, Malhotra R, Isselbacher EM, ... Lindsay ME, et al. An HDAC9-MALAT1-BRG1 complex mediates smooth muscle dysfunction in thoracic aortic aneurysm. Nature Communications. 9: 1009. PMID 29520069 DOI: 10.1038/S41467-018-03394-7  0.42
2018 Lino Cardenas CL, Kessinger CW, MacDonald C, Jassar AS, Isselbacher EM, Jaffer FA, Lindsay ME. Inhibition of the methyltranferase EZH2 improves aortic performance in experimental thoracic aortic aneurysm. Jci Insight. 3. PMID 29515022 DOI: 10.1172/Jci.Insight.97493  0.434
2018 Hayes SN, Kim ESH, Saw J, Adlam D, Arslanian-Engoren C, Economy KE, Ganesh SK, Gulati R, Lindsay ME, Mieres JH, Naderi S, Shah S, Thaler DE, Tweet MS, Wood MJ, et al. Spontaneous Coronary Artery Dissection: Current State of the Science: A Scientific Statement From the American Heart Association. Circulation. PMID 29472380 DOI: 10.1161/Cir.0000000000000564  0.328
2018 Schepers D, Tortora G, Morisaki H, MacCarrick G, Lindsay M, Liang D, Mehta SG, Hague J, Verhagen J, van de Laar I, Wessels M, Detisch Y, van Haelst M, Baas A, Lichtenbelt K, et al. A mutation update on the LDS associated genes TGFB2/3 and SMAD2/3. Human Mutation. PMID 29392890 DOI: 10.1002/Humu.23407  0.356
2018 Kaadan MI, Ponzini F, Mishra S, Duran J, Tsiaras S, Ghoshhajra B, Lindsay M, Wood M. Sex Differences In The Clinical Presentation Of Spontaneous Coronary Artery Dissection (Scad) At Massachusetts General Hospital Journal of the American College of Cardiology. 71. DOI: 10.1016/S0735-1097(18)31946-6  0.306
2017 Newell K, Smith W, Ghoshhajra B, Isselbacher E, Lin A, Lindsay ME. Cervical artery dissection expands the cardiovascular phenotype in FBN1-related Weill-Marchesani syndrome. American Journal of Medical Genetics. Part A. PMID 28696036 DOI: 10.1002/Ajmg.A.38353  0.464
2016 Kim JB, Spotnitz M, Lindsay ME, MacGillivray TE, Isselbacher EM, Sundt TM. Risk of Aortic Dissection in the Moderately Dilated Ascending Aorta. Journal of the American College of Cardiology. 68: 1209-19. PMID 27609684 DOI: 10.1016/J.Jacc.2016.06.025  0.4
2016 Isselbacher EM, Bonaca MP, Di Eusanio M, Froehlich J, Bossone E, Sechtem U, Pyeritz R, Patel H, Khoynezhad A, Eckstein HH, Jondeau G, Ramponi F, Abbasi M, Montgomery D, Nienaber CA, ... ... Lindsay ME, et al. Recurrent Aortic Dissection: Observations from the International Registry of Aortic Dissection (IRAD). Circulation. PMID 27587434 DOI: 10.1161/Circulationaha.115.019359  0.36
2016 Lin AE, Michot C, Cormier-Daire V, L'Ecuyer TJ, Matherne GP, Barnes BH, Humberson JB, Edmondson AC, Zackai E, O'Connor MJ, Kaplan JD, Ebeid MR, Krier J, Krieg E, Ghoshhajra B, ... Lindsay ME, et al. Gain-of-function mutations in SMAD4 cause a distinctive repertoire of cardiovascular phenotypes in patients with Myhre syndrome. American Journal of Medical Genetics. Part A. PMID 27302097 DOI: 10.1002/Ajmg.A.37739  0.378
2016 Isselbacher EM, Lino Cardenas CL, Lindsay ME. Hereditary Influence in Thoracic Aortic Aneurysm and Dissection. Circulation. 133: 2516-28. PMID 27297344 DOI: 10.1161/Circulationaha.116.009762  0.455
2016 Vapnik JS, Kim JB, Isselbacher EM, Ghoshhajra BB, Cheng Y, Sundt TM, MacGillivray TE, Cambria RP, Lindsay ME. Characteristics and Outcomes of Ascending Versus Descending Thoracic Aortic Aneurysms. The American Journal of Cardiology. PMID 27015890 DOI: 10.1016/J.Amjcard.2016.02.048  0.414
2015 Martin PS, Kloesel B, Norris RA, Lindsay M, Milan D, Body SC. Embryonic Development of the Bicuspid Aortic Valve. Journal of Cardiovascular Development and Disease. 2: 248-272. PMID 28529942 DOI: 10.3390/Jcdd2040248  0.442
2015 Doyle JJ, Doyle AJ, Wilson NK, Habashi JP, Bedja D, Whitworth RE, Lindsay ME, Schoenhoff F, Myers L, Huso N, Bachir S, Squires O, Rusholme B, Ehsan H, Huso D, et al. A deleterious gene-by-environment interaction imposed by calcium channel blockers in Marfan syndrome. Elife. 4. PMID 26506064 DOI: 10.7554/Elife.08648  0.431
2015 Kim JB, Kim K, Lindsay ME, MacGillivray T, Isselbacher EM, Cambria RP, Sundt TM. Risk of Rupture or Dissection in Descending Thoracic Aortic Aneurysm. Circulation. PMID 26338955 DOI: 10.1161/Circulationaha.114.015177  0.421
2015 Ptaszek LM, Kim K, Spooner AE, MacGillivray TE, Cambria RP, Lindsay ME, Isselbacher EM. Marfan syndrome is associated with recurrent dissection of the dissected aorta. The Annals of Thoracic Surgery. 99: 1616-23. PMID 25818572 DOI: 10.1016/J.Athoracsur.2014.12.066  0.447
2014 Lindsay ME, Dietz HC. The genetic basis of aortic aneurysm. Cold Spring Harbor Perspectives in Medicine. 4: a015909. PMID 25183854 DOI: 10.1101/Cshperspect.A015909  0.431
2014 Gallo EM, Loch DC, Habashi JP, Calderon JF, Chen Y, Bedja D, van Erp C, Gerber EE, Parker SJ, Sauls K, Judge DP, Cooke SK, Lindsay ME, Rouf R, Myers L, et al. Angiotensin II-dependent TGF-β signaling contributes to Loeys-Dietz syndrome vascular pathogenesis. The Journal of Clinical Investigation. 124: 448-60. PMID 24355923 DOI: 10.1172/Jci69666  0.364
2013 Kane MS, Lindsay ME, Judge DP, Barrowman J, Ap Rhys C, Simonson L, Dietz HC, Michaelis S. LMNA-associated cardiocutaneous progeria: an inherited autosomal dominant premature aging syndrome with late onset. American Journal of Medical Genetics. Part A. 161: 1599-611. PMID 23666920 DOI: 10.1002/Ajmg.A.35971  0.323
2012 Doyle AJ, Doyle JJ, Bessling SL, Maragh S, Lindsay ME, Schepers D, Gillis E, Mortier G, Homfray T, Sauls K, Norris RA, Huso ND, Leahy D, Mohr DW, Caulfield MJ, et al. Mutations in the TGF-β repressor SKI cause Shprintzen-Goldberg syndrome with aortic aneurysm. Nature Genetics. 44: 1249-54. PMID 23023332 DOI: 10.1038/Ng.2421  0.401
2012 Lindsay ME, Schepers D, Bolar NA, Doyle JJ, Gallo E, Fert-Bober J, Kempers MJ, Fishman EK, Chen Y, Myers L, Bjeda D, Oswald G, Elias AF, Levy HP, Anderlid BM, et al. Loss-of-function mutations in TGFB2 cause a syndromic presentation of thoracic aortic aneurysm. Nature Genetics. 44: 922-7. PMID 22772368 DOI: 10.1038/Ng.2349  0.409
2011 Lindsay ME, Dietz HC. Lessons on the pathogenesis of aneurysm from heritable conditions. Nature. 473: 308-16. PMID 21593863 DOI: 10.1038/Nature10145  0.437
2011 Holm TM, Habashi JP, Doyle JJ, Bedja D, Chen Y, van Erp C, Lindsay ME, Kim D, Schoenhoff F, Cohn RD, Loeys BL, Thomas CJ, Patnaik S, Marugan JJ, Judge DP, et al. Noncanonical TGFβ signaling contributes to aortic aneurysm progression in Marfan syndrome mice. Science (New York, N.Y.). 332: 358-61. PMID 21493862 DOI: 10.1126/Science.1192149  0.386
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