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Emily R. Derbyshire, Ph.D. - Publications

Affiliations: 
2008 University of California, Berkeley, Berkeley, CA, United States 
 2014 Harvard Medical School 
 2014- Duke University, Durham, NC 
Area:
catalytic and biological properties of redox enzymes
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45 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2020 Ganley JG, Pandey A, Sylvester K, Lu KY, Toro-Moreno M, Rütschlin S, Bradford JM, Champion CJ, Böttcher T, Xu J, Derbyshire ER. A Systematic Analysis of Mosquito-Microbiome Biosynthetic Gene Clusters Reveals Antimalarial Siderophores that Reduce Mosquito Reproduction Capacity. Cell Chemical Biology. PMID 32619453 DOI: 10.1016/J.Chembiol.2020.06.004  0.565
2020 Lu KY, Quan B, Sylvester K, Srivastava T, Fitzgerald MC, Derbyshire ER. chaperonin TRiC/CCT identified as a target of the antihistamine clemastine using parallel chemoproteomic strategy. Proceedings of the National Academy of Sciences of the United States of America. PMID 32127489 DOI: 10.1073/Pnas.1913525117  0.375
2020 Lu KY, Derbyshire ER. Tafenoquine: A step toward malaria elimination. Biochemistry. PMID 32073254 DOI: 10.1021/Acs.Biochem.9B01105  0.344
2020 Toro-Moreno M, Sylvester K, Srivastava T, Posfai D, Derbyshire ER. RNA-Seq Analysis Illuminates the Early Stages of Liver Infection. Mbio. 11. PMID 32019802 DOI: 10.1128/Mbio.03234-19  0.305
2019 D'Ambrosio HK, Derbyshire ER. Investigating the Role of Class I Adenylate-Forming Enzymes in Natural Product Biosynthesis. Acs Chemical Biology. PMID 31815417 DOI: 10.1021/Acschembio.9B00865  0.335
2019 Szamosvári D, Sylvester K, Schmid P, Lu KY, Derbyshire ER, Böttcher T. Close the ring to break the cycle: tandem quinolone-alkyne-cyclisation gives access to tricyclic pyrrolo[1,2-a]quinolin-5-ones with potent anti-protozoal activity. Chemical Communications (Cambridge, England). PMID 31119221 DOI: 10.1039/C9Cc01689A  0.588
2018 Raphemot R, Eubanks AL, Toro-Moreno M, Geiger RA, Hughes PF, Lu KY, Haystead TAJ, Derbyshire ER. Plasmodium PK9 Inhibitors Promote Growth of Liver-Stage Parasites. Cell Chemical Biology. PMID 30595530 DOI: 10.1016/J.Chembiol.2018.11.003  0.65
2018 Eubanks A, Perkins M, Sylvester K, Ganley J, Posfai D, Sanschargrin P, Hong J, Sliz P, Derbyshire E. In silico Screening and Evaluation of Plasmodium falciparum Protein Kinase 5 (PK5) Inhibitors. Chemmedchem. PMID 30328274 DOI: 10.1002/Cmdc.201800625  0.338
2018 Ganley J, Carr G, Ioerger T, Sacchettini J, Clardy J, Derbyshire E. Discovery of antimicrobial lipodepsipeptides produced by a Serratia sp. within mosquito microbiomes. Chembiochem : a European Journal of Chemical Biology. PMID 29700993 DOI: 10.1002/Cbic.201800124  0.444
2018 Posfai D, Eubanks AL, Keim AI, Lu KY, Wang GZ, Hughes PF, Kato N, Haystead TA, Derbyshire ER. Identification of Hsp90 inhibitors with anti-Plasmodium activity. Antimicrobial Agents and Chemotherapy. PMID 29339390 DOI: 10.1128/Aac.01799-17  0.648
2018 Ganley JG, Carr G, Ioerger TR, Sacchettini JC, Clardy J, Derbyshire ER. Front Cover: Discovery of Antimicrobial Lipodepsipeptides Produced by a Serratia sp. within Mosquito Microbiomes (ChemBioChem 15/2018) Chembiochem. 19: 1570-1570. DOI: 10.1002/Cbic.201800362  0.374
2017 Totzke J, Gurbani D, Raphemot R, Hughes PF, Bodoor K, Carlson DA, Loiselle DR, Bera AK, Eibschutz LS, Perkins MM, Eubanks AL, Campbell PL, Fox DA, Westover KD, Haystead TAJ, ... Derbyshire ER, et al. Takinib, a Selective TAK1 Inhibitor, Broadens the Therapeutic Efficacy of TNF-α Inhibition for Cancer and Autoimmune Disease. Cell Chemical Biology. 24: 1029-1039.e7. PMID 28820959 DOI: 10.1016/J.Chembiol.2017.07.011  0.616
2016 Kato N, Comer E, Sakata-Kato T, Sharma A, Sharma M, Maetani M, Bastien J, Brancucci NM, Bittker JA, Corey V, Clarke D, Derbyshire ER, Dornan G, Duffy S, Eckley S, et al. Diversity-oriented synthesis yields novel multistage antimalarial inhibitors. Nature. PMID 27602946 DOI: 10.1038/Nature19804  0.462
2015 Raphemot R, Lafuente-Monasterio MJ, Gamo-Benito FJ, Clardy J, Derbyshire ER. Discovery of Dual Stage Malaria Inhibitors with New Targets. Antimicrobial Agents and Chemotherapy. PMID 26666931 DOI: 10.1128/Aac.02110-15  0.472
2015 Herman JD, Pepper LR, Cortese JF, Estiu G, Galinsky K, Zuzarte-Luis V, Derbyshire ER, Ribacke U, Lukens AK, Santos SA, Patel V, Clish CB, Sullivan WJ, Zhou H, Bopp SE, et al. The cytoplasmic prolyl-tRNA synthetase of the malaria parasite is a dual-stage target of febrifugine and its analogs. Science Translational Medicine. 7: 288ra77. PMID 25995223 DOI: 10.1126/Scitranslmed.Aaa3575  0.468
2014 Derbyshire ER, Zuzarte-Luís V, Magalhães AD, Kato N, Sanschagrin PC, Wang J, Zhou W, Miduturu CV, Mazitschek R, Sliz P, Mota MM, Gray NS, Clardy J. Chemical interrogation of the malaria kinome. Chembiochem : a European Journal of Chemical Biology. 15: 1920-30. PMID 25111632 DOI: 10.1002/Cbic.201400025  0.472
2014 Derbyshire ER, Min J, Guiguemde WA, Clark JA, Connelly MC, Magalhães AD, Guy RK, Clardy J. Dihydroquinazolinone inhibitors of proliferation of blood and liver stage malaria parasites. Antimicrobial Agents and Chemotherapy. 58: 1516-22. PMID 24366746 DOI: 10.1128/Aac.02148-13  0.48
2014 Derbyshire ER, Zuzarte-Luís V, Magalhães AD, Kato N, Sanschagrin PC, Wang J, Zhou W, Miduturu CV, Mazitschek R, Sliz P, Mota MM, Gray NS, Clardy J. Cover Picture: Chemical Interrogation of the Malaria Kinome (ChemBioChem 13/2014) Chembiochem. 15: 1841-1841. DOI: 10.1002/Cbic.201490045  0.4
2013 Derbyshire ER, Clardy J. Closing in on a new treatment for sleeping sickness. Elife. 2: e01042. PMID 23853715 DOI: 10.7554/Elife.01042  0.369
2013 Derbyshire ER, Clardy J. Correction: Closing in on a new treatment for sleeping sickness Elife. 2. DOI: 10.7554/Elife.01221  0.351
2012 Fernhoff NB, Derbyshire ER, Underbakke ES, Marletta MA. Heme-assisted S-nitrosation desensitizes ferric soluble guanylate cyclase to nitric oxide. The Journal of Biological Chemistry. 287: 43053-62. PMID 23093402 DOI: 10.1074/Jbc.M112.393892  0.738
2012 Carr G, Derbyshire ER, Caldera E, Currie CR, Clardy J. Antibiotic and antimalarial quinones from fungus-growing ant-associated Pseudonocardia sp. Journal of Natural Products. 75: 1806-9. PMID 23025282 DOI: 10.1021/Np300380T  0.452
2012 Gunn A, Derbyshire ER, Marletta MA, Britt RD. Conformationally distinct five-coordinate heme-NO complexes of soluble guanylate cyclase elucidated by multifrequency electron paramagnetic resonance (EPR). Biochemistry. 51: 8384-90. PMID 22985445 DOI: 10.1021/Bi300831M  0.568
2012 Derbyshire ER, Prudêncio M, Mota MM, Clardy J. Liver-stage malaria parasites vulnerable to diverse chemical scaffolds. Proceedings of the National Academy of Sciences of the United States of America. 109: 8511-6. PMID 22586124 DOI: 10.1073/Pnas.1118370109  0.459
2012 Derbyshire ER, Mazitschek R, Clardy J. Characterization of Plasmodium liver stage inhibition by halofuginone. Chemmedchem. 7: 844-9. PMID 22438279 DOI: 10.1002/Cmdc.201200045  0.476
2012 Derbyshire ER, Marletta MA. Structure and regulation of soluble guanylate cyclase. Annual Review of Biochemistry. 81: 533-59. PMID 22404633 DOI: 10.1146/Annurev-Biochem-050410-100030  0.608
2012 Derbyshire ER, Mazitschek R, Clardy J. Cover Picture: Characterization of Plasmodium Liver Stage Inhibition by Halofuginone (ChemMedChem 5/2012) Chemmedchem. 7: 745-745. DOI: 10.1002/Cmdc.201290018  0.429
2011 Dong CK, Urgaonkar S, Cortese JF, Gamo FJ, Garcia-Bustos JF, Lafuente MJ, Patel V, Ross L, Coleman BI, Derbyshire ER, Clish CB, Serrano AE, Cromwell M, Barker RH, Dvorin JD, et al. Identification and validation of tetracyclic benzothiazepines as Plasmodium falciparum cytochrome bc1 inhibitors. Chemistry & Biology. 18: 1602-10. PMID 22195562 DOI: 10.1016/J.Chembiol.2011.09.016  0.489
2011 Derbyshire ER, Mota MM, Clardy J. The next opportunity in anti-malaria drug discovery: the liver stage. Plos Pathogens. 7: e1002178. PMID 21966266 DOI: 10.1371/Journal.Ppat.1002178  0.432
2011 Derbyshire ER, Winter MB, Ibrahim M, Deng S, Spiro TG, Marletta MA. Probing domain interactions in soluble guanylate cyclase. Biochemistry. 50: 4281-90. PMID 21491957 DOI: 10.1021/Bi200341B  0.7
2010 Ibrahim M, Derbyshire ER, Soldatova AV, Marletta MA, Spiro TG. Soluble guanylate cyclase is activated differently by excess NO and by YC-1: resonance Raman spectroscopic evidence. Biochemistry. 49: 4864-71. PMID 20459051 DOI: 10.1021/Bi100506J  0.613
2010 Ibrahim M, Derbyshire ER, Marletta MA, Spiro TG. Probing soluble guanylate cyclase activation by CO and YC-1 using resonance Raman spectroscopy. Biochemistry. 49: 3815-23. PMID 20353168 DOI: 10.1021/Bi902214J  0.578
2010 Derbyshire ER, Deng S, Marletta MA. Incorporation of tyrosine and glutamine residues into the soluble guanylate cyclase heme distal pocket alters NO and O2 binding. The Journal of Biological Chemistry. 285: 17471-8. PMID 20231286 DOI: 10.1074/Jbc.M109.098269  0.574
2009 Fernhoff NB, Derbyshire ER, Marletta MA. A nitric oxide/cysteine interaction mediates the activation of soluble guanylate cyclase. Proceedings of the National Academy of Sciences of the United States of America. 106: 21602-7. PMID 20007374 DOI: 10.1073/Pnas.0911083106  0.8
2009 Derbyshire ER, Fernhoff NB, Deng S, Marletta MA. Nucleotide regulation of soluble guanylate cyclase substrate specificity. Biochemistry. 48: 7519-24. PMID 19527054 DOI: 10.1021/Bi900696X  0.782
2009 Derbyshire ER, Marletta MA. Biochemistry of soluble guanylate cyclase. Handbook of Experimental Pharmacology. 17-31. PMID 19089323 DOI: 10.1007/978-3-540-68964-5_2  0.615
2009 Marletta MA, Derbyshire ER, Erbil WK, Fernhoff NB, Kuriyan J, Olea C, Price MS, Wemmer DE. A molecular view of the regulation of sGC activity Bmc Pharmacology. 9. DOI: 10.1186/1471-2210-9-S1-S27  0.731
2008 Winger JA, Derbyshire ER, Lamers MH, Marletta MA, Kuriyan J. The crystal structure of the catalytic domain of a eukaryotic guanylate cyclase. Bmc Structural Biology. 8: 42. PMID 18842118 DOI: 10.1186/1472-6807-8-42  0.694
2008 Derbyshire ER, Gunn A, Ibrahim M, Spiro TG, Britt RD, Marletta MA. Characterization of two different five-coordinate soluble guanylate cyclase ferrous-nitrosyl complexes. Biochemistry. 47: 3892-9. PMID 18302323 DOI: 10.1021/Bi7022943  0.55
2007 Derbyshire ER, Marletta MA. Butyl isocyanide as a probe of the activation mechanism of soluble guanylate cyclase. Investigating the role of non-heme nitric oxide. The Journal of Biological Chemistry. 282: 35741-8. PMID 17916555 DOI: 10.1074/Jbc.M705557200  0.641
2007 Martin NI, Derbyshire ER, Marletta MA. Synthesis and evaluation of a phosphonate analogue of the soluble guanylate cyclase activator YC-1. Bioorganic & Medicinal Chemistry Letters. 17: 4938-41. PMID 17587571 DOI: 10.1016/J.Bmcl.2007.06.039  0.727
2007 Winger JA, Derbyshire ER, Marletta MA. Dissociation of nitric oxide from soluble guanylate cyclase and heme-nitric oxide/oxygen binding domain constructs. The Journal of Biological Chemistry. 282: 897-907. PMID 17098738 DOI: 10.1074/Jbc.M606327200  0.699
2007 Boon EM, Cary SP, Huang SH, Winger JA, Derbyshire ER, Price MS, Erbil WK, Marletta MA. Molecular steps in sGC activation Bmc Pharmacology. 7: S27. DOI: 10.1186/1471-2210-7-S1-S27  0.712
2006 Cary SP, Winger JA, Derbyshire ER, Marletta MA. Nitric oxide signaling: no longer simply on or off. Trends in Biochemical Sciences. 31: 231-9. PMID 16530415 DOI: 10.1016/J.Tibs.2006.02.003  0.783
2005 Derbyshire ER, Tran R, Mathies RA, Marletta MA. Characterization of nitrosoalkane binding and activation of soluble guanylate cyclase. Biochemistry. 44: 16257-65. PMID 16331986 DOI: 10.1021/Bi0515671  0.61
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