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Eileen J. Kennedy, Ph.D. - Publications

Affiliations: 
2000-2005 Chemistry and biochemistry University of California, San Diego, La Jolla, CA 
 2006-2010 Chemistry and Chemical Biology Harvard University, Cambridge, MA, United States 
 2010- Pharmaceutical and Biomedical Sciences University of Georgia, Athens, Athens, GA, United States 
Area:
constrained peptides, kinases, kinase signaling, protein-protein interactions
Website:
http://pbs.rx.uga.edu/people/faculty-members/eileen-kennedy/
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46 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2023 Alexander KK, Naaldijk Y, Fasiczka R, Brahmia B, Chen T, Hilfiker S, Kennedy EJ. Targeting Rab-RILPL interactions as a strategy to downregulate pathogenic LRRK2 in Parkinson's disease. Journal of Peptide Science : An Official Publication of the European Peptide Society. e3563. PMID 38135900 DOI: 10.1002/psc.3563  0.488
2023 Pathak P, Alexander KK, Helton LG, Kentros M, LeClair TJ, Zhang X, Ho FY, Moore TT, Hall S, Guaitoli G, Gloeckner CJ, Kortholt A, Rideout H, Kennedy EJ. Doubly Constrained C-terminal of Roc (COR) Domain-Derived Peptides Inhibit Leucine-Rich Repeat Kinase 2 (LRRK2) Dimerization. Acs Chemical Neuroscience. PMID 37200505 DOI: 10.1021/acschemneuro.3c00259  0.49
2022 Limaye AJ, Whittaker MK, Bendzunas GN, Cowell JK, Kennedy EJ. Targeting the WASF3 Complex to Suppress Metastasis. Pharmacological Research. 106302. PMID 35691539 DOI: 10.1016/j.phrs.2022.106302  0.766
2022 Limaye AJ, Bendzunas GN, Whittaker MK, LeClair TJ, Helton LG, Kennedy EJ. Optimized Stapled Peptides Targeting WASF3 in Breast Cancer. Acs Medicinal Chemistry Letters. 13: 570-576. PMID 35450347 DOI: 10.1021/acsmedchemlett.1c00627  0.753
2022 Byrne DP, Omar MH, Kennedy EJ, Eyers PA, Scott JD. Biochemical Analysis of AKAP-Anchored PKA Signaling Complexes. Methods in Molecular Biology (Clifton, N.J.). 2483: 297-317. PMID 35286684 DOI: 10.1007/978-1-0716-2245-2_19  0.452
2022 Singh RK, Soliman A, Guaitoli G, Störmer E, von Zweydorf F, Dal Maso T, Oun A, Van Rillaer L, Schmidt SH, Chatterjee D, David JA, Pardon E, Schwartz TU, Knapp S, Kennedy EJ, et al. Nanobodies as allosteric modulators of Parkinson's disease-associated LRRK2. Proceedings of the National Academy of Sciences of the United States of America. 119. PMID 35217606 DOI: 10.1073/pnas.2112712119  0.405
2021 Helton LG, Soliman A, von Zweydorf F, Kentros M, Manschwetus JT, Hall S, Gilsbach B, Ho FY, Athanasopoulos PS, Singh RK, LeClair TJ, Versées W, Raimondi F, Herberg FW, Gloeckner CJ, ... ... Kennedy EJ, et al. Allosteric Inhibition of Parkinson's-Linked LRRK2 by Constrained Peptides. Acs Chemical Biology. PMID 34496561 DOI: 10.1021/acschembio.1c00487  0.4
2021 Limaye AJ, Bendzunas GN, Kennedy EJ. Targeted disruption of PKC from AKAP signaling complexes. Rsc Chemical Biology. 2: 1227-1231. PMID 34458835 DOI: 10.1039/d1cb00106j  0.812
2021 Lasonder E, More K, Singh S, Haidar M, Bertinetti D, Kennedy EJ, Herberg FW, Holder AA, Langsley G, Chitnis CE. cAMP-Dependent Signaling Pathways as Potential Targets for Inhibition of Blood Stages. Frontiers in Microbiology. 12: 684005. PMID 34108954 DOI: 10.3389/fmicb.2021.684005  0.433
2021 Baffi TR, Lordén G, Wozniak JM, Feichtner A, Yeung W, Kornev AP, King CC, Del Rio JC, Limaye AJ, Bogomolovas J, Gould CM, Chen J, Kennedy EJ, Kannan N, Gonzalez DJ, et al. mTORC2 controls the activity of PKC and Akt by phosphorylating a conserved TOR interaction motif. Science Signaling. 14. PMID 33850054 DOI: 10.1126/scisignal.abe4509  0.789
2020 Helton LG, Kennedy EJ. Targeting Plasmodium with constrained peptides and peptidomimetics. Iubmb Life. PMID 32037730 DOI: 10.1002/Iub.2244  0.441
2019 Manschwetus JT, Bendzunas GN, Limaye AJ, Knape MJ, Herberg FW, Kennedy EJ. A Stapled Peptide Mimic of the Pseudosubstrate Inhibitor PKI Inhibits Protein Kinase A. Molecules (Basel, Switzerland). 24. PMID 31009996 DOI: 10.3390/Molecules24081567  0.807
2019 Cao Z, Singh B, Li C, Markham NO, Carrington LJ, Franklin JL, Graves-Deal R, Kennedy EJ, Goldenring JR, Coffey RJ. PKA-mediated phosphorylation of NKD2 stimulates cell-surface delivery of TGF-α for EGFR transactivation. Traffic (Copenhagen, Denmark). PMID 30941853 DOI: 10.1111/Tra.12642  0.477
2019 Flaherty B, Ho TG, Schmidt S, Herberg FW, Peterson D, Kennedy E. Targeted Inhibition of Plasmodium falciparum Calcium-Dependent Protein Kinase 1 With A Constrained J Domain-Derived Disruptor Peptide. Acs Infectious Diseases. PMID 30746930 DOI: 10.1021/Acsinfecdis.8B00347  0.516
2018 Kennedy EJ. Constrained peptides and biological targets. Bioorganic & Medicinal Chemistry. 26: 1117. PMID 29519596 DOI: 10.1016/J.Bmc.2018.02.046  0.432
2018 Burgess SG, Mukherjee M, Sabir S, Joseph N, Gutiérrez-Caballero C, Richards MW, Huguenin-Dezot N, Chin JW, Kennedy EJ, Pfuhl M, Royle SJ, Gergely F, Bayliss R. Mitotic spindle association of TACC3 requires Aurora-A-dependent stabilization of a cryptic α-helix. The Embo Journal. PMID 29510984 DOI: 10.15252/Embj.201797902  0.445
2018 Bendzunas NG, Dörfler S, Autenrieth K, Bertinetti D, Machal EMF, Kennedy EJ, Herberg FW. Investigating PKA-RII specificity using analogs of the PKA:AKAP peptide inhibitor STAD-2. Bioorganic & Medicinal Chemistry. PMID 29449124 DOI: 10.1016/J.Bmc.2018.02.001  0.56
2017 Haidar M, de Laté PL, Kennedy EJ, Langsley G. Cell penetrating peptides to dissect host-pathogen protein-protein interactions in Theileria-transformed leukocytes. Bioorganic & Medicinal Chemistry. PMID 28917447 DOI: 10.1016/J.Bmc.2017.08.056  0.534
2017 Fulton MD, Hanold LE, Ruan Z, Patel S, Beedle AM, Kannan N, Kennedy EJ. Conformationally constrained peptides target the allosteric kinase dimer interface and inhibit EGFR activation. Bioorganic & Medicinal Chemistry. PMID 28911855 DOI: 10.1016/J.Bmc.2017.08.051  0.82
2017 Cowell JK, Teng Y, Bendzunas NG, Ara R, Arbab AS, Kennedy EJ. Suppression of Breast Cancer Metastasis Using Stapled Peptides Targeting the WASF Regulatory Complex. Cancer Growth and Metastasis. 10: 1179064417713197. PMID 28680267 DOI: 10.1177/1179064417713197  0.353
2017 Mo GC, Ross B, Hertel F, Manna P, Yang X, Greenwald E, Booth C, Plummer AM, Tenner B, Chen Z, Wang Y, Kennedy EJ, Cole PA, Fleming KG, Palmer A, et al. Genetically encoded biosensors for visualizing live-cell biochemical activity at super-resolution. Nature Methods. PMID 28288122 DOI: 10.1038/Nmeth.4221  0.622
2017 Hanold LE, Fulton MD, Kennedy EJ. Targeting kinase signaling pathways with constrained peptide scaffolds. Pharmacology & Therapeutics. PMID 28185915 DOI: 10.1016/J.Pharmthera.2017.02.014  0.827
2017 Haidar M, Lombes A, Bouillaud F, Kennedy EJ, Langsley G. HK2 recruitment to phospho-BAD prevents its degradation promoting Warburg glycolysis by Theileria-transformed leukocytes. Acs Infectious Diseases. PMID 28086019 DOI: 10.1021/Acsinfecdis.6B00180  0.411
2016 Haidar M, Ramdani G, Kennedy EJ, Langsley G. PKA and Apicomplexan Parasite Diseases. Hormone and Metabolic Research = Hormon- Und Stoffwechselforschung = Hormones Et Metabolisme. PMID 27875850 DOI: 10.1055/S-0042-121366  0.457
2016 Haidar M, Ramdani G, Kennedy EJ, Langsley G. PKA and Apicomplexan Parasite Diseases. Hormone and Metabolic Research = Hormon- Und Stoffwechselforschung = Hormones Et Metabolisme. PMID 27835919 DOI: 10.1055/s-0042-118459  0.352
2016 Mohanty S, Oruganty K, Kwon A, Byrne DP, Ferries S, Ruan Z, Hanold LE, Katiyar S, Kennedy EJ, Eyers PA, Kannan N. Correction: Hydrophobic Core Variations Provide a Structural Framework for Tyrosine Kinase Evolution and Functional Specialization. Plos Genetics. 12: e1006265. PMID 27513745 DOI: 10.1371/journal.pgen.1006265  0.749
2016 Teng Y, Qin H, Bahssan A, Bendzunas G, Kennedy EJ, Cowell J. The WASF3-NCKAP1-CYFIP1 complex is essential for breast cancer metastasis. Cancer Research. PMID 27432794 DOI: 10.1158/0008-5472.Can-16-0562  0.412
2016 Götz F, Roske Y, Schulz MS, Autenrieth K, Bertinetti D, Faelber K, Zühlke K, Kreuchwig A, Kennedy E, Krause G, Daumke O, Herberg FW, Heinemann U, Klussmann E. AKAP18:PKA-RIIα structure reveals crucial anchor points for recognition of regulatory subunits of PKA. The Biochemical Journal. PMID 27102985 DOI: 10.1042/Bcj20160242  0.431
2016 Mohanty S, Oruganty K, Kwon A, Byrne DP, Ferries S, Ruan Z, Hanold LE, Katiyar S, Kennedy EJ, Eyers PA, Kannan N. Hydrophobic Core Variations Provide a Structural Framework for Tyrosine Kinase Evolution and Functional Specialization. Plos Genetics. 12: e1005885. PMID 26925779 DOI: 10.1371/Journal.Pgen.1005885  0.793
2016 Bavencoffe A, Li Y, Wu Z, Yang Q, Herrera J, Kennedy EJ, Walters ET, Dessauer CW. Persistent Electrical Activity in Primary Nociceptors after Spinal Cord Injury Is Maintained by Scaffolded Adenylyl Cyclase and Protein Kinase A and Is Associated with Altered Adenylyl Cyclase Regulation. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 36: 1660-8. PMID 26843647 DOI: 10.1523/Jneurosci.0895-15.2016  0.366
2015 Teng Y, Bahassan A, Dong D, Hanold LE, Ren X, Kennedy EJ, Cowell J. Targeting the WASF3-CYFIP1 complex using stapled peptides suppresses cancer cell invasion. Cancer Research. PMID 26676744 DOI: 10.1158/0008-5472.Can-15-1680  0.793
2015 Autenrieth K, Bendzunas G, Bertinetti D, Herberg FW, Kennedy EJ. Defining A-Kinase Anchoring Protein (AKAP) Specificity for Protein Kinase A Subunit RI (PKA-RI). Chembiochem : a European Journal of Chemical Biology. PMID 26611881 DOI: 10.1002/Cbic.201500632  0.52
2015 Kennedy EJ, Kannan N. Dialing in EGFR Signaling. Chemistry & Biology. 22: 687-8. PMID 26091165 DOI: 10.1016/J.Chembiol.2015.06.001  0.417
2015 Flaherty BR, Wang Y, Trope EC, Ho TG, Muralidharan V, Kennedy EJ, Peterson DS. The Stapled AKAP Disruptor Peptide STAD-2 Displays Antimalarial Activity through a PKA-Independent Mechanism. Plos One. 10: e0129239. PMID 26010880 DOI: 10.1371/Journal.Pone.0129239  0.679
2015 Hermann JS, Skroblin P, Bertinetti D, Hanold LE, von der Heide EK, Wagener EM, Zenn HM, Klussmann E, Kennedy EJ, Herberg FW. Neurochondrin is an atypical RIIα-specific A-kinase anchoring protein. Biochimica Et Biophysica Acta. PMID 25916936 DOI: 10.1016/J.Bbapap.2015.04.018  0.805
2015 Mohanty S, Kennedy EJ, Herberg FW, Hui R, Taylor SS, Langsley G, Kannan N. Structural and evolutionary divergence of cyclic nucleotide binding domains in eukaryotic pathogens: Implications for drug design. Biochimica Et Biophysica Acta. PMID 25847873 DOI: 10.1016/J.Bbapap.2015.03.012  0.361
2015 Hanold LE, Watkins CP, Ton NT, Liaw P, Beedle AM, Kennedy EJ. Design of a selenylsulfide-bridged EGFR dimerization arm mimic. Bioorganic & Medicinal Chemistry. 23: 2761-6. PMID 25840798 DOI: 10.1016/J.Bmc.2015.03.040  0.787
2015 Hanold LE, Oruganty K, Ton NT, Beedle AM, Kannan N, Kennedy EJ. Inhibiting EGFR dimerization using triazolyl-bridged dimerization arm mimics. Plos One. 10: e0118796. PMID 25790232 DOI: 10.1371/Journal.Pone.0118796  0.786
2015 Kennedy EJ, Scott JD. Selective disruption of the AKAP signaling complexes. Methods in Molecular Biology (Clifton, N.J.). 1294: 137-50. PMID 25783883 DOI: 10.1007/978-1-4939-2537-7_11  0.583
2015 Wang Y, Ho TG, Franz E, Hermann JS, Smith FD, Hehnly H, Esseltine JL, Hanold LE, Murph MM, Bertinetti D, Scott JD, Herberg FW, Kennedy EJ. PKA-Type I Selective Constrained Peptide Disruptors of AKAP Complexes. Acs Chemical Biology. 10: 1502-10. PMID 25765284 DOI: 10.1021/Acschembio.5B00009  0.817
2014 Wang Y, Ho TG, Bertinetti D, Neddermann M, Franz E, Mo GC, Schendowich LP, Sukhu A, Spelts RC, Zhang J, Herberg FW, Kennedy EJ. Isoform-selective disruption of AKAP-localized PKA using hydrocarbon stapled peptides. Acs Chemical Biology. 9: 635-42. PMID 24422448 DOI: 10.1021/Cb400900R  0.746
2014 Wang Y, Ho TG, Bertinetti D, Neddermann M, Franz E, Mo GCH, Schendowich LP, Sukhu A, Spelts RC, Zhang J, Herberg FW, Kennedy EJ. Correction to Isoform-Selective Disruption of AKAP-Localized PKA Using Hydrocarbon Stapled Peptides Acs Chemical Biology. 9: 1386-1386. DOI: 10.1021/Cb500329Z  0.639
2009 Kennedy EJ, Yang J, Pillus L, Taylor SS, Ghosh G. Identifying critical non-catalytic residues that modulate protein kinase A activity. Plos One. 4: e4746. PMID 19270744 DOI: 10.1371/Journal.Pone.0004746  0.646
2009 Yang J, Kennedy EJ, Wu J, Deal MS, Pennypacker J, Ghosh G, Taylor SS. Contribution of non-catalytic core residues to activity and regulation in protein kinase A. The Journal of Biological Chemistry. 284: 6241-8. PMID 19122195 DOI: 10.1074/Jbc.M805862200  0.636
2008 Kennedy EJ, Ghosh G, Pillus L. Identification of functionally distinct regions that mediate biological activity of the protein kinase a homolog Tpk2. The Journal of Biological Chemistry. 283: 1084-93. PMID 17971450 DOI: 10.1074/Jbc.M704028200  0.66
2005 Kennedy EJ, Pillus L, Ghosh G. Pho5p and newly identified nucleotide pyrophosphatases/ phosphodiesterases regulate extracellular nucleotide phosphate metabolism in Saccharomyces cerevisiae. Eukaryotic Cell. 4: 1892-901. PMID 16278456 DOI: 10.1128/Ec.4.11.1892-1901.2005  0.531
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