Lawrence S. Shapiro, Phd - Publications

Affiliations: 
Columbia University, New York, NY 
Area:
Synapses and Circuits, Axon Pathfinding and Synaptogenesis, Biophysics/Ion Channels, Cellular/Molecular/Developmental Neuroscience

131 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2023 Nagendra K, Izzet A, Judd NB, Zakine R, Friedman L, Harrison OJ, Pontani LL, Shapiro L, Honig B, Brujic J. Push-pull mechanics of E-cadherin ectodomains in biomimetic adhesions. Biophysical Journal. PMID 37528581 DOI: 10.1016/j.bpj.2023.07.026  0.52
2023 Sergeeva AP, Katsamba PS, Liao J, Sampson JM, Bahna F, Mannepalli S, Morano NC, Shapiro L, Friesner RA, Honig B. Free Energy Perturbation Calculations of Mutation Effects on SARS-CoV-2 RBD::ACE2 Binding Affinity. Journal of Molecular Biology. 435: 168187. PMID 37355034 DOI: 10.1016/j.jmb.2023.168187  0.776
2022 Mangou K, Moore AJ, Thiam LG, Ba A, Orfanó A, Desamours I, Ndegwa DN, Goodwin J, Guo Y, Sheng Z, Patel SD, Diallo F, Sene SD, Pouye MN, Faye AT, ... ... Shapiro L, et al. Structure-guided insights into potential function of novel genetic variants in the malaria vaccine candidate PfRh5. Scientific Reports. 12: 19403. PMID 36371450 DOI: 10.1038/s41598-022-23929-9  0.532
2022 Boni N, Shapiro L, Honig B, Wu Y, Rubinstein R. On the formation of ordered protein assemblies in cell-cell interfaces. Proceedings of the National Academy of Sciences of the United States of America. 119: e2206175119. PMID 35969779 DOI: 10.1073/pnas.2206175119  0.521
2022 Xu S, Sergeeva AP, Katsamba PS, Mannepalli S, Bahna F, Bimela J, Zipursky SL, Shapiro L, Honig B, Zinn K. Affinity requirements for control of synaptic targeting and neuronal cell survival by heterophilic IgSF cell adhesion molecules. Cell Reports. 39: 110618. PMID 35385751 DOI: 10.1016/j.celrep.2022.110618  0.724
2022 Goodman KM, Katsamba PS, Rubinstein R, Ahlsén G, Bahna F, Mannepalli S, Dan H, Sampogna RV, Shapiro L, Honig B. How clustered protocadherin binding specificity is tuned for neuronal self-/nonself-recognition. Elife. 11. PMID 35253643 DOI: 10.7554/eLife.72416  0.496
2021 Sheng Z, Bimela JS, Katsamba PS, Patel SD, Guo Y, Zhao H, Guo Y, Kwong PD, Shapiro L. Structural Basis of Antibody Conformation and Stability Modulation by Framework Somatic Hypermutation. Frontiers in Immunology. 12: 811632. PMID 35046963 DOI: 10.3389/fimmu.2021.811632  0.673
2021 Blockus H, Rolotti SV, Szoboszlay M, Peze-Heidsieck E, Ming T, Schroeder A, Apostolo N, Vennekens KM, Katsamba PS, Bahna F, Mannepalli S, Ahlsen G, Honig B, Shapiro L, de Wit J, et al. Synaptogenic activity of the axon guidance molecule Robo2 underlies hippocampal circuit function. Cell Reports. 37: 109828. PMID 34686348 DOI: 10.1016/j.celrep.2021.109828  0.428
2021 Troyanovsky RB, Sergeeva AP, Indra I, Chen CS, Kato R, Shapiro L, Honig B, Troyanovsky SM. Sorting of cadherin-catenin-associated proteins into individual clusters. Proceedings of the National Academy of Sciences of the United States of America. 118. PMID 34272290 DOI: 10.1073/pnas.2105550118  0.683
2021 Koss H, Honig B, Shapiro L, Palmer AG. Dimerization of Cadherin-11 involves multi-site coupled unfolding and strand swapping. Structure (London, England : 1993). PMID 34166612 DOI: 10.1016/j.str.2021.06.006  0.454
2020 Zhou T, Tsybovsky Y, Gorman J, Rapp M, Cerutti G, Chuang GY, Katsamba PS, Sampson JM, Schön A, Bimela J, Boyington JC, Nazzari A, Olia AS, Shi W, Sastry M, ... ... Shapiro L, et al. Cryo-EM Structures of SARS-CoV-2 Spike without and with ACE2 Reveal a pH-Dependent Switch to Mediate Endosomal Positioning of Receptor-Binding Domains. Cell Host & Microbe. PMID 33271067 DOI: 10.1016/j.chom.2020.11.004  0.76
2020 Liu L, Wang P, Nair MS, Yu J, Rapp M, Wang Q, Luo Y, Chan JF, Sahi V, Figueroa A, Guo XV, Cerutti G, Bimela J, Gorman J, Zhou T, ... ... Shapiro L, et al. Potent neutralizing antibodies directed to multiple epitopes on SARS-CoV-2 spike. Nature. PMID 32698192 DOI: 10.1038/S41586-020-2571-7  0.306
2020 Zhou T, Tsybovsky Y, Olia AS, Gorman J, Rapp MA, Cerutti G, Katsamba PS, Nazzari A, Schon A, Wang PD, Bimela J, Shi W, Teng IT, Zhang B, Boyington JC, ... ... Shapiro L, et al. A pH-dependent switch mediates conformational masking of SARS-CoV-2 spike. Biorxiv : the Preprint Server For Biology. PMID 32637958 DOI: 10.1101/2020.07.04.187989  0.753
2020 Jin W, Madan B, Mussman BK, Hailemariam AT, Fahad AS, Wolfe JR, Kwon YD, Zhang B, Shapiro L, Kwong PD, DeKosky BJ. The Covalent SNAP Tag for Protein Display Quantification and Low-pH Protein Engineering. Journal of Biotechnology. PMID 32561362 DOI: 10.1016/J.Jbiotec.2020.06.011  0.33
2020 Honig B, Shapiro L. Adhesion Protein Structure, Molecular Affinities, and Principles of Cell-Cell Recognition Cell. 181: 520-535. PMID 32359436 DOI: 10.1016/J.Cell.2020.04.010  0.588
2020 Sergeeva AP, Katsamba PS, Cosmanescu F, Brewer JJ, Ahlsen G, Mannepalli S, Shapiro L, Honig B. DIP/Dpr interactions and the evolutionary design of specificity in protein families. Nature Communications. 11: 2125. PMID 32358559 DOI: 10.1038/S41467-020-15981-8  0.757
2020 Gorman J, Chuang GY, Lai YT, Shen CH, Boyington JC, Druz A, Geng H, Louder MK, McKee K, Rawi R, Verardi R, Yang Y, Zhang B, Doria-Rose NA, Lin B, ... ... Shapiro L, et al. Structure of Super-Potent Antibody CAP256-VRC26.25 in Complex with HIV-1 Envelope Reveals a Combined Mode of Trimer-Apex Recognition. Cell Reports. 31: 107488. PMID 32268107 DOI: 10.1016/J.Celrep.2020.03.052  0.32
2020 Indra I, Troyanovsky RB, Shapiro L, Honig B, Troyanovsky SM. Sensing Actin Dynamics through Adherens Junctions. Cell Reports. 30: 2820-2833.e3. PMID 32101754 DOI: 10.1016/J.Celrep.2020.01.106  0.49
2020 Harrison OJ, Brasch J, Katsamba PS, Ahlsen G, Noble AJ, Dan H, Sampogna RV, Potter CS, Carragher B, Honig B, Shapiro L. Family-wide Structural and Biophysical Analysis of Binding Interactions among Non-clustered δ-Protocadherins. Cell Reports. 30: 2655-2671.e7. PMID 32101743 DOI: 10.1016/J.Celrep.2020.02.003  0.565
2019 Phad GE, Pushparaj P, Tran K, Dubrovskaya V, Àdori M, Martinez-Murillo P, Vázquez Bernat N, Singh S, Dionne G, O'Dell S, Bhullar K, Narang S, Sorini C, Villablanca EJ, Sundling C, ... ... Shapiro L, et al. Extensive dissemination and intraclonal maturation of HIV Env vaccine-induced B cell responses. The Journal of Experimental Medicine. PMID 31704807 DOI: 10.1084/Jem.20191155  0.309
2019 Guo Y, Chen K, Kwong PD, Shapiro L, Sheng Z. cAb-Rep: A Database of Curated Antibody Repertoires for Exploring Antibody Diversity and Predicting Antibody Prevalence. Frontiers in Immunology. 10: 2365. PMID 31649674 DOI: 10.3389/Fimmu.2019.02365  0.306
2019 Gorman J, Mason RD, Nettey L, Cavett N, Chuang GY, Peng D, Tsybovsky Y, Verardi R, Nguyen R, Ambrozak D, Biris K, LaBranche CC, Ramesh A, Schramm CA, Zhou J, ... ... Shapiro L, et al. Isolation and Structure of an Antibody that Fully Neutralizes Isolate SIVmac239 Reveals Functional Similarity of SIV and HIV Glycan Shields. Immunity. PMID 31586542 DOI: 10.1016/J.Immuni.2019.09.007  0.333
2019 Generous AR, Harrison OJ, Troyanovsky RB, Mateo M, Navaratnarajah CK, Donohue RC, Pfaller CK, Alekhina O, Sergeeva AP, Indra I, Thornburg T, Kochetkova I, Billadeau DD, Taylor MP, Troyanovsky SM, ... ... Shapiro L, et al. Trans-endocytosis elicited by nectins transfers cytoplasmic cargo including infectious material between cells. Journal of Cell Science. PMID 31331966 DOI: 10.1242/Jcs.235507  0.721
2019 Brasch J, Goodman KM, Noble AJ, Rapp M, Mannepalli S, Bahna F, Dandey VP, Bepler T, Berger B, Maniatis T, Potter CS, Carragher B, Honig B, Shapiro L. Visualization of clustered protocadherin neuronal self-recognition complexes. Nature. PMID 30971825 DOI: 10.1038/s41586-019-1089-3  0.532
2018 van Eeden C, Wibmer CK, Scheepers C, Richardson SI, Nonyane M, Lambson B, Mkhize NN, Vijayakumar B, Sheng Z, Stanfield-Oakley S, Bhiman JN, Bekker V, Hermanus T, Mabvakure B, Ismail A, ... ... Shapiro L, et al. V2-Directed Vaccine-like Antibodies from HIV-1 Infection Identify an Additional K169-Binding Light Chain Motif with Broad ADCC Activity. Cell Reports. 25: 3123-3135.e6. PMID 30540944 DOI: 10.1016/J.Celrep.2018.11.058  0.318
2018 Cosmanescu F, Katsamba PS, Sergeeva AP, Ahlsen G, Patel SD, Brewer JJ, Tan L, Xu S, Xiao Q, Nagarkar-Jaiswal S, Nern A, Bellen HJ, Zipursky SL, Honig B, Shapiro L. Neuron-Subtype-Specific Expression, Interaction Affinities, and Specificity Determinants of DIP/Dpr Cell Recognition Proteins. Neuron. PMID 30467080 DOI: 10.1016/J.Neuron.2018.10.046  0.797
2018 Xu S, Xiao Q, Cosmanescu F, Sergeeva AP, Yoo J, Lin Y, Katsamba PS, Ahlsen G, Kaufman J, Linaval NT, Lee PT, Bellen HJ, Shapiro L, Honig B, Tan L, et al. Interactions between the Ig-Superfamily Proteins DIP-α and Dpr6/10 Regulate Assembly of Neural Circuits. Neuron. PMID 30467079 DOI: 10.1016/J.Neuron.2018.11.001  0.742
2018 Zeiske T, Baburajendran N, Kaczynska A, Brasch J, Palmer AG, Shapiro L, Honig B, Mann RS. Intrinsic DNA Shape Accounts for Affinity Differences between Hox-Cofactor Binding Sites. Cell Reports. 24: 2221-2230. PMID 30157419 DOI: 10.1016/J.Celrep.2018.07.100  0.545
2018 Dionne G, Qiu X, Rapp M, Liang X, Zhao B, Peng G, Katsamba PS, Ahlsen G, Rubinstein R, Potter CS, Carragher B, Honig B, Müller U, Shapiro L. Mechanotransduction by PCDH15 Relies on a Novel cis-Dimeric Architecture. Neuron. PMID 30057206 DOI: 10.1016/J.Neuron.2018.07.006  0.543
2018 Brasch J, Katsamba PS, Harrison OJ, Ahlsén G, Troyanovsky RB, Indra I, Kaczynska A, Kaeser B, Troyanovsky S, Honig B, Shapiro L. Homophilic and Heterophilic Interactions of Type II Cadherins Identify Specificity Groups Underlying Cell-Adhesive Behavior. Cell Reports. 23: 1840-1852. PMID 29742438 DOI: 10.1016/J.Celrep.2018.04.012  0.588
2018 Indra I, Choi J, Chen CS, Troyanovsky RB, Shapiro L, Honig B, Troyanovsky SM. Spatial and temporal organization of cadherin in punctate adherens junctions. Proceedings of the National Academy of Sciences of the United States of America. PMID 29691319 DOI: 10.1073/Pnas.1720826115  0.52
2018 Zhou T, Zheng A, Baxa U, Chuang GY, Georgiev IS, Kong R, O'Dell S, Shahzad-Ul-Hussan S, Shen CH, Tsybovsky Y, Bailer RT, Gift SK, Louder MK, McKee K, Rawi R, ... ... Shapiro L, et al. A Neutralizing Antibody Recognizing Primarily N-linked Glycan Targets the Silent Face of the HIV Envelope. Immunity. PMID 29548671 DOI: 10.1016/J.Immuni.2018.02.013  0.302
2018 Kwon YD, Chuang GY, Zhang B, Bailer RT, Doria-Rose NA, Gindin TS, Lin B, Louder MK, McKee K, O'Dell S, Pegu A, Schmidt SD, Asokan M, Chen X, Choe M, ... ... Shapiro L, et al. Surface-Matrix Screening Identifies Semi-specific Interactions that Improve Potency of a Near Pan-reactive HIV-1-Neutralizing Antibody. Cell Reports. 22: 1798-1809. PMID 29444432 DOI: 10.1016/J.Celrep.2018.01.023  0.319
2018 Evangelista F, Roth AJ, Prisayanh P, Temple BR, Li N, Qian Y, Culton DA, Liu Z, Harrison OJ, Brasch J, Honig B, Shapiro L, Diaz LA. Pathogenic IgG4 autoantibodies from endemic pemphigus foliaceus recognize a desmoglein-1 conformational epitope. Journal of Autoimmunity. PMID 29307589 DOI: 10.1016/J.Jaut.2017.12.017  0.583
2018 Cosmanescu F, Katsamba PS, Sergeeva AP, Ahlsen G, Patel SD, Brewer JJ, Tan L, Xu S, Xiao Q, Nagarkar-Jaiswal S, Bellen H, Zipursky SL, Honig B, Shapiro L. Quantitative interactome for DIP/Dpr Immunoglubin Superfamily Cell Recognition Proteins Neuron. DOI: 10.2210/Pdb6Efy/Pdb  0.779
2018 Prisayanh P, Evangelista F, Roth A, Temple B, Li N, Qian Y, Culton D, Liu Z, Harrison O, Brasch J, Honig B, Shapiro L, Diaz L. 039 Pathogenic IgG4 anti-Dsg1 autoantibodies from endemic pemphigus foliaceus inhibit the heterophilic Dsg1/Dsc1 adhesive interactions Journal of Investigative Dermatology. 138: S7. DOI: 10.1016/J.Jid.2018.03.043  0.497
2018 Cosmanescu F, Katsamba PS, Sergeeva AP, Ahlsen G, Patel S, Brewer J, Tan L, Xu S, Xiao Q, Zipursky SL, Honig B, Shapiro L. Family-Wide Biophysical Analysis of Dpr-DIP Interactions Biophysical Journal. 114: 154a. DOI: 10.1016/J.Bpj.2017.11.865  0.758
2017 Goodman KM, Rubinstein R, Dan H, Bahna F, Mannepalli S, Ahlsén G, Aye Thu C, Sampogna RV, Maniatis T, Honig B, Shapiro L. Protocadherin cis-dimer architecture and recognition unit diversity. Proceedings of the National Academy of Sciences of the United States of America. PMID 29087338 DOI: 10.1073/Pnas.1713449114  0.551
2017 Larsen ISB, Narimatsu Y, Joshi HJ, Siukstaite L, Harrison OJ, Brasch J, Goodman KM, Hansen L, Shapiro L, Honig B, Vakhrushev SY, Clausen H, Halim A. Discovery of an O-mannosylation pathway selectively serving cadherins and protocadherins. Proceedings of the National Academy of Sciences of the United States of America. PMID 28973932 DOI: 10.1073/Pnas.1708319114  0.473
2017 Rubinstein R, Goodman KM, Maniatis T, Shapiro L, Honig B. Structural origins of clustered protocadherin-mediated neuronal barcoding. Seminars in Cell & Developmental Biology. PMID 28743640 DOI: 10.1016/J.Semcdb.2017.07.023  0.53
2017 Larsen ISB, Narimatsu Y, Joshi HJ, Yang Z, Harrison OJ, Brasch J, Shapiro L, Honig B, Vakhrushev SY, Clausen H, Halim A. Mammalian O-mannosylation of Cadherins and Plexins is Independent of Protein O-mannosyltransferase 1 and 2. The Journal of Biological Chemistry. PMID 28512129 DOI: 10.1074/Jbc.M117.794487  0.473
2017 Goodman KM, Rubinstein R, Brasch J, Thu CA, Bahna F, Mannepalli S, Dan H, Sampogna RV, Maniatis T, Honig B, Shapiro L. Clustered protocadherin molecular assembly and implications for neuronal self-avoidance Acta Crystallographica Section a Foundations and Advances. 73: a50-a50. DOI: 10.1107/S0108767317099500  0.471
2016 Clark AJ, Gindin T, Zhang B, Wang L, Abel R, Murret CS, Xu F, Bao A, Lu NJ, Zhou T, Kwong PD, Shapiro L, Honig B, Friesner RA. Free Energy Perturbation Calculation of Relative Binding Free energy between Broadly Neutralizing Antibodies and the gp120 Glycoprotein of HIV-1. Journal of Molecular Biology. PMID 27908641 DOI: 10.1016/J.Jmb.2016.11.021  0.646
2016 Goodman KM, Rubinstein R, Thu CA, Mannepalli S, Bahna F, Ahlsén G, Rittenhouse C, Maniatis T, Honig B, Shapiro L. γ-Protocadherin structural diversity and functional implications. Elife. 5. PMID 27782885 DOI: 10.7554/Elife.20930  0.568
2016 Goodman KM, Yamagata M, Jin X, Mannepalli S, Katsamba PS, Ahlsén G, Sergeeva AP, Honig B, Sanes JR, Shapiro L. Molecular basis of sidekick-mediated cell-cell adhesion and specificity. Elife. 5. PMID 27644106 DOI: 10.7554/Elife.19058  0.766
2016 Chen Y, Clarke OB, Kim J, Stowe S, Kim YK, Assur Z, Cavalier M, Godoy-Ruiz R, von Alpen DC, Manzini C, Blaner WS, Frank J, Quadro L, Weber DJ, Shapiro L, et al. Structure of the STRA6 receptor for retinol uptake. Science (New York, N.Y.). 353. PMID 27563101 DOI: 10.1126/Science.Aad8266  0.537
2016 Soto C, Ofek G, Joyce MG, Zhang B, McKee K, Longo NS, Yang Y, Huang J, Parks R, Eudailey J, Lloyd KE, Alam SM, Haynes BF, Mullikin JC, ... ... Shapiro L, et al. Developmental Pathway of the MPER-Directed HIV-1-Neutralizing Antibody 10E8. Plos One. 11: e0157409. PMID 27299673 DOI: 10.1371/Journal.Pone.0157409  0.303
2016 Harrison OJ, Brasch J, Lasso G, Katsamba PS, Ahlsen G, Honig B, Shapiro L. Structural basis of adhesive binding by desmocollins and desmogleins. Proceedings of the National Academy of Sciences of the United States of America. PMID 27298358 DOI: 10.1073/Pnas.1606272113  0.576
2016 Goodman KM, Rubinstein R, Thu CA, Bahna F, Mannepalli S, Ahlsén G, Rittenhouse C, Maniatis T, Honig B, Shapiro L. Structural Basis of Diverse Homophilic Recognition by Clustered α- and β-Protocadherins. Neuron. PMID 27161523 DOI: 10.1016/J.Neuron.2016.04.004  0.563
2016 Mason RD, Welles HC, Adams C, Chakrabarti BK, Gorman J, Zhou T, Nguyen R, O'Dell S, Lusvarghi S, Bewley CA, Li H, Shaw GM, Sheng Z, Shapiro L, Wyatt R, et al. Targeted Isolation of Antibodies Directed against Major Sites of SIV Env Vulnerability. Plos Pathogens. 12: e1005537. PMID 27064278 DOI: 10.1371/Journal.Ppat.1005537  0.311
2016 Petrou VI, Herrera CM, Schultz KM, Clarke OB, Vendome J, Tomasek D, Banerjee S, Rajashankar KR, Belcher Dufrisne M, Kloss B, Kloppmann E, Rost B, Klug CS, Trent MS, Shapiro L, et al. Structures of aminoarabinose transferase ArnT suggest a molecular basis for lipid A glycosylation. Science (New York, N.Y.). 351: 608-12. PMID 26912703 DOI: 10.1126/Science.Aad1172  0.304
2016 Ardiccioni C, Clarke OB, Tomasek D, Issa HA, von Alpen DC, Pond HL, Banerjee S, Rajashankar KR, Liu Q, Guan Z, Li C, Kloss B, Bruni R, Kloppmann E, Rost B, ... ... Shapiro L, et al. Structure of the polyisoprenyl-phosphate glycosyltransferase GtrB and insights into the mechanism of catalysis. Nature Communications. 7: 10175. PMID 26729507 DOI: 10.1038/Ncomms10175  0.327
2016 Goodman KM, Rubinstein R, Thu CA, Mannepalli S, Bahna F, Ahlsén G, Rittenhouse C, Maniatis T, Honig B, Shapiro L. Author response: γ-Protocadherin structural diversity and functional implications Elife. DOI: 10.7554/Elife.20930.064  0.477
2016 Goodman KM, Yamagata M, Jin X, Mannepalli S, Katsamba PS, Ahlsén G, Sergeeva AP, Honig B, Sanes JR, Shapiro L. Author response: Molecular basis of sidekick-mediated cell-cell adhesion and specificity Elife. DOI: 10.7554/Elife.19058.021  0.719
2015 Gorman J, Soto C, Yang MM, Davenport TM, Guttman M, Bailer RT, Chambers M, Chuang GY, DeKosky BJ, Doria-Rose NA, Druz A, Ernandes MJ, Georgiev IS, Jarosinski MC, Joyce MG, ... ... Shapiro L, et al. Structures of HIV-1 Env V1V2 with broadly neutralizing antibodies reveal commonalities that enable vaccine design. Nature Structural & Molecular Biology. PMID 26689967 DOI: 10.1038/Nsmb.3144  0.317
2015 Clarke OB, Tomasek D, Jorge CD, Dufrisne MB, Kim M, Banerjee S, Rajashankar KR, Shapiro L, Hendrickson WA, Santos H, Mancia F. Structural basis for phosphatidylinositol-phosphate biosynthesis. Nature Communications. 6: 8505. PMID 26510127 DOI: 10.1016/J.Bpj.2015.11.392  0.526
2015 Rubinstein R, Thu CA, Goodman KM, Wolcott HN, Bahna F, Mannepalli S, Ahlsen G, Chevee M, Halim A, Clausen H, Maniatis T, Shapiro L, Honig B. Molecular Logic of Neuronal Self-Recognition through Protocadherin Domain Interactions. Cell. 163: 629-42. PMID 26478182 DOI: 10.1016/J.Cell.2015.09.026  0.597
2015 Doria-Rose NA, Bhiman JN, Roark RS, Schramm CA, Gorman J, Chuang GY, Pancera M, Cale EM, Ernandes MJ, Louder MK, Asokan M, Bailer RT, Druz A, Fraschilla IR, Garrett NJ, ... ... Shapiro L, et al. A new member of the V1V2-directed CAP256-VRC26 lineage that shows increased breadth and exceptional potency. Journal of Virology. PMID 26468542 DOI: 10.1128/Jvi.01791-15  0.304
2015 Biswas KH, Hartman KL, Yu CH, Harrison OJ, Song H, Smith AW, Huang WY, Lin WC, Guo Z, Padmanabhan A, Troyanovsky SM, Dustin ML, Shapiro L, Honig B, Zaidel-Bar R, et al. E-cadherin junction formation involves an active kinetic nucleation process. Proceedings of the National Academy of Sciences of the United States of America. 112: 10932-7. PMID 26290581 DOI: 10.1073/Pnas.1513775112  0.538
2015 Chen CS, Hong S, Indra I, Sergeeva AP, Troyanovsky RB, Shapiro L, Honig B, Troyanovsky SM. α-Catenin-mediated cadherin clustering couples cadherin and actin dynamics. The Journal of Cell Biology. PMID 26261181 DOI: 10.1083/Jcb.201412064  0.73
2015 Do Kwon Y, Pancera M, Acharya P, Georgiev IS, Crooks ET, Gorman J, Joyce MG, Guttman M, Ma X, Narpala S, Soto C, Terry DS, Yang Y, Zhou T, Ahlsen G, ... ... Shapiro L, et al. Crystal structure, conformational fixation and entry-related interactions of mature ligand-free HIV-1 Env. Nature Structural & Molecular Biology. 22: 522-31. PMID 26098315 DOI: 10.1038/Nsmb.3051  0.34
2015 Petrou VI, Clarke OB, Schultz KM, Tomasek D, Kloss B, Banerjee S, Rajashankar KR, Klug CS, Shapiro L, Mancia F. Crystal Structure of the Bacterial Aminoarabinose Transferase ArnT Biophysical Journal. 108: 253a. DOI: 10.1016/J.Bpj.2014.11.1400  0.317
2014 Vendome J, Felsovalyi K, Song H, Yang Z, Jin X, Brasch J, Harrison OJ, Ahlsen G, Bahna F, Kaczynska A, Katsamba PS, Edmond D, Hubbell WL, Shapiro L, Honig B. Structural and energetic determinants of adhesive binding specificity in type I cadherins. Proceedings of the National Academy of Sciences of the United States of America. 111: E4175-84. PMID 25253890 DOI: 10.1073/Pnas.1416737111  0.591
2014 Thu CA, Chen WV, Rubinstein R, Chevee M, Wolcott HN, Felsovalyi KO, Tapia JC, Shapiro L, Honig B, Maniatis T. Single-cell identity generated by combinatorial homophilic interactions between α, β, and γ protocadherins. Cell. 158: 1045-59. PMID 25171406 DOI: 10.1016/J.Cell.2014.07.012  0.582
2014 Doria-Rose NA, Roark RS, Moore P, Ernandes MJ, Bhiman JN, Schramm CA, McKee K, O'Dell S, Louder M, Karim SSA, Shapiro L, Morris L, Mascola JR. Variable Dependence on Glycan Recognition within a Lineage of V1V2-directed HIV Neutralizing Antibodies Aids Research and Human Retroviruses. 30: A88-A89. DOI: 10.1089/Aid.2014.5161.Abstract  0.307
2014 Lynch RM, Yamamoto T, Wong P, Georgiev I, Matus-Nicodemos R, Schmidt S, Gautam R, Sheng Z, Shapiro L, Nishimura Y, Martin MA, Mascola JR, Koup RA. Isolation of Monoclonal Antibodies from a SHIV-AD8 Infected Rhesus Macaque with Broad Neutralizing Activity Aids Research and Human Retroviruses. 30. DOI: 10.1089/Aid.2014.5145.Abstract  0.318
2014 Song H, Yang Z, Felsovalyi K, Hubbell W, Shapiro L, Honig B. Structural and Energetic Determinants of Adhesive Binding Specificity in Type I Cadherins: The Role of Multiple Conformations in Tuning Affinities Biophysical Journal. 106: 464a. DOI: 10.1016/J.Bpj.2013.11.2628  0.614
2013 Li Y, Altorelli NL, Bahna F, Honig B, Shapiro L, Palmer AG. Mechanism of E-cadherin dimerization probed by NMR relaxation dispersion. Proceedings of the National Academy of Sciences of the United States of America. 110: 16462-7. PMID 24067646 DOI: 10.1073/Pnas.1314303110  0.565
2013 Zhou T, Zhu J, Wu X, Moquin S, Zhang B, Acharya P, Georgiev IS, Altae-Tran HR, Chuang GY, Joyce MG, Do Kwon Y, Longo NS, Louder MK, Luongo T, McKee K, ... ... Shapiro L, et al. Multidonor analysis reveals structural elements, genetic determinants, and maturation pathway for HIV-1 neutralization by VRC01-class antibodies. Immunity. 39: 245-58. PMID 23911655 DOI: 10.1016/J.Immuni.2013.04.012  0.302
2012 Quadri SK, Sun L, Islam MN, Shapiro L, Bhattacharya J. Cadherin selectivity filter regulates endothelial sieving properties Nature Communications. 3. PMID 23033075 DOI: 10.1038/Ncomms2107  0.345
2012 Harrison OJ, Vendome J, Brasch J, Jin X, Hong S, Katsamba PS, Ahlsen G, Troyanovsky RB, Troyanovsky SM, Honig B, Shapiro L. Nectin ectodomain structures reveal a canonical adhesive interface. Nature Structural & Molecular Biology. 19: 906-15. PMID 22902367 DOI: 10.1038/Nsmb.2366  0.602
2012 Liu Q, Dahmane T, Zhang Z, Assur Z, Brasch J, Shapiro L, Mancia F, Hendrickson WA. Structures from anomalous diffraction of native biological macromolecules. Science (New York, N.Y.). 336: 1033-7. PMID 22628655 DOI: 10.1126/Science.1218753  0.521
2012 Brasch J, Harrison OJ, Honig B, Shapiro L. Thinking outside the cell: how cadherins drive adhesion. Trends in Cell Biology. 22: 299-310. PMID 22555008 DOI: 10.1016/J.Tcb.2012.03.004  0.59
2012 Wu W, Ahlsen G, Baker D, Shapiro L, Zipursky SL. Complementary chimeric isoforms reveal Dscam1 binding specificity in vivo. Neuron. 74: 261-8. PMID 22542180 DOI: 10.1016/J.Neuron.2012.02.029  0.379
2012 Jin X, Walker MA, Felsövályi K, Vendome J, Bahna F, Mannepalli S, Cosmanescu F, Ahlsen G, Honig B, Shapiro L. Crystal structures of Drosophila N-cadherin ectodomain regions reveal a widely used class of Ca²+-free interdomain linkers. Proceedings of the National Academy of Sciences of the United States of America. 109: E127-34. PMID 22171007 DOI: 10.1073/Pnas.1117538108  0.691
2012 Liu Q, Dahmane T, Zhang Z, Assur Z, Brasch J, Shapiro L, Mancia F, Hendrickson WA. Structures from anomalous diffraction of native biological macromolecules Science. 336: 1033-1037. DOI: 10.1126/science.1218753  0.441
2011 Brasch J, Harrison OJ, Ahlsen G, Liu Q, Shapiro L. Crystal structure of the ligand binding domain of netrin g2. Journal of Molecular Biology. 414: 723-734. PMID 22041449 DOI: 10.1016/J.Jmb.2011.10.030  0.389
2011 Wu Y, Vendome J, Shapiro L, Ben-Shaul A, Honig B. Transforming binding affinities from three dimensions to two with application to cadherin clustering. Nature. 475: 510-3. PMID 21796210 DOI: 10.1038/Nature10183  0.574
2011 Vendome J, Posy S, Jin X, Bahna F, Ahlsen G, Shapiro L, Honig B. Molecular design principles underlying β-strand swapping in the adhesive dimerization of cadherins. Nature Structural & Molecular Biology. 18: 693-700. PMID 21572446 DOI: 10.1038/Nsmb.2051  0.566
2011 Harrison OJ, Jin X, Hong S, Bahna F, Ahlsen G, Brasch J, Wu Y, Vendome J, Felsovalyi K, Hampton CM, Troyanovsky RB, Ben-Shaul A, Frank J, Troyanovsky SM, Shapiro L, et al. The extracellular architecture of adherens junctions revealed by crystal structures of type I cadherins. Structure (London, England : 1993). 19: 244-56. PMID 21300292 DOI: 10.1016/J.Str.2010.11.016  0.572
2011 Brasch J, Harrison OJ, Ahlsen G, Carnally SM, Henderson RM, Honig B, Shapiro L. Structure and binding mechanism of vascular endothelial cadherin: a divergent classical cadherin. Journal of Molecular Biology. 408: 57-73. PMID 21269602 DOI: 10.1016/J.Jmb.2011.01.031  0.58
2011 Wu Y, Shapiro L, Ben-Shaul A, Honig B. Multiscale Simulation of Cadherin-Mediated Cell Adhesion Biophysical Journal. 100. DOI: 10.1016/J.Bpj.2010.12.324  0.607
2010 Wu Y, Jin X, Harrison O, Shapiro L, Honig BH, Ben-Shaul A. Cooperativity between trans and cis interactions in cadherin-mediated junction formation. Proceedings of the National Academy of Sciences of the United States of America. 107: 17592-7. PMID 20876147 DOI: 10.1073/Pnas.1011247107  0.542
2010 Love J, Mancia F, Shapiro L, Punta M, Rost B, Girvin M, Wang DN, Zhou M, Hunt JF, Szyperski T, Gouaux E, MacKinnon R, McDermott A, Honig B, Inouye M, et al. The New York Consortium on Membrane Protein Structure (NYCOMPS): a high-throughput platform for structural genomics of integral membrane proteins. Journal of Structural and Functional Genomics. 11: 191-9. PMID 20690043 DOI: 10.1007/S10969-010-9094-7  0.633
2010 Koehnke J, Katsamba PS, Ahlsen G, Bahna F, Vendome J, Honig B, Shapiro L, Jin X. Splice form dependence of beta-neurexin/neuroligin binding interactions. Neuron. 67: 61-74. PMID 20624592 DOI: 10.1016/J.Neuron.2010.06.001  0.695
2010 Ciatto C, Bahna F, Zampieri N, VanSteenhouse HC, Katsamba PS, Ahlsen G, Harrison OJ, Brasch J, Jin X, Posy S, Vendome J, Ranscht B, Jessell TM, Honig B, Shapiro L. T-cadherin structures reveal a novel adhesive binding mechanism. Nature Structural & Molecular Biology. 17: 339-47. PMID 20190755 DOI: 10.1038/Nsmb.1781  0.558
2010 Harrison OJ, Bahna F, Katsamba PS, Jin X, Brasch J, Vendome J, Ahlsen G, Carroll KJ, Price SR, Honig B, Shapiro L. Two-step adhesive binding by classical cadherins. Nature Structural & Molecular Biology. 17: 348-57. PMID 20190754 DOI: 10.1038/Nsmb.1784  0.566
2009 Shapiro L, Weis WI. Structure and biochemistry of cadherins and catenins. Cold Spring Harbor Perspectives in Biology. 1: a003053. PMID 20066110 DOI: 10.1101/Cshperspect.A003053  0.605
2009 Punta M, Love J, Handelman S, Hunt JF, Shapiro L, Hendrickson WA, Rost B. Structural genomics target selection for the New York consortium on membrane protein structure. Journal of Structural and Functional Genomics. 10: 255-68. PMID 19859826 DOI: 10.1007/S10969-009-9071-1  0.522
2009 Katsamba P, Carroll K, Ahlsen G, Bahna F, Vendome J, Posy S, Rajebhosale M, Price S, Jessell TM, Ben-Shaul A, Shapiro L, Honig BH. Linking molecular affinity and cellular specificity in cadherin-mediated adhesion. Proceedings of the National Academy of Sciences of the United States of America. 106: 11594-9. PMID 19553217 DOI: 10.1073/Pnas.0905349106  0.581
2008 Miloushev VZ, Bahna F, Ciatto C, Ahlsen G, Honig B, Shapiro L, Palmer AG. Dynamic properties of a type II cadherin adhesive domain: implications for the mechanism of strand-swapping of classical cadherins. Structure (London, England : 1993). 16: 1195-205. PMID 18682221 DOI: 10.1016/J.Str.2008.05.009  0.537
2008 Posy S, Shapiro L, Honig B. Sequence and structural determinants of strand swapping in cadherin domains: do all cadherins bind through the same adhesive interface? Journal of Molecular Biology. 378: 954-68. PMID 18395225 DOI: 10.1016/J.Jmb.2008.02.063  0.597
2008 Koehnke J, Jin X, Trbovic N, Katsamba PS, Brasch J, Ahlsen G, Scheiffele P, Honig B, Palmer AG, Shapiro L. Crystal structures of beta-neurexin 1 and beta-neurexin 2 ectodomains and dynamics of splice insertion sequence 4. Structure (London, England : 1993). 16: 410-21. PMID 18334216 DOI: 10.1016/J.Str.2007.12.024  0.696
2008 Koehnke J, Jin X, Budreck EC, Posy S, Scheiffele P, Honig B, Shapiro L. Crystal structure of the extracellular cholinesterase-like domain from neuroligin-2. Proceedings of the National Academy of Sciences of the United States of America. 105: 1873-8. PMID 18250328 DOI: 10.1073/Pnas.0711701105  0.746
2008 Pocock R, Bénard CY, Shapiro L, Hobert O. Functional dissection of the C. elegans cell adhesion molecule SAX-7, a homologue of human L1. Molecular and Cellular Neurosciences. 37: 56-68. PMID 17933550 DOI: 10.1016/J.Mcn.2007.08.014  0.398
2007 Jin X, Townley R, Shapiro L. Structural insight into AMPK regulation: ADP comes into play. Structure (London, England : 1993). 15: 1285-95. PMID 17937917 DOI: 10.1016/J.Str.2007.07.017  0.6
2007 Shapiro L. Self-Recognition at the Atomic Level: Understanding the Astonishing Molecular Diversity of Homophilic Dscams Neuron. 56: 10-13. PMID 17920010 DOI: 10.1016/J.Neuron.2007.09.024  0.36
2007 Shapiro L, Love J, Colman DR. Adhesion molecules in the nervous system: structural insights into function and diversity. Annual Review of Neuroscience. 30: 451-74. PMID 17600523 DOI: 10.1146/Annurev.Neuro.29.051605.113034  0.396
2007 Townley R, Shapiro L. Crystal structures of the adenylate sensor from fission yeast AMP-activated protein kinase. Science (New York, N.Y.). 315: 1726-9. PMID 17289942 DOI: 10.1126/Science.1137503  0.592
2007 Jefferson JJ, Ciatto C, Shapiro L, Liem RK. Structural analysis of the plakin domain of bullous pemphigoid antigen1 (BPAG1) suggests that plakins are members of the spectrin superfamily. Journal of Molecular Biology. 366: 244-57. PMID 17161423 DOI: 10.1016/J.Jmb.2006.11.036  0.404
2007 Shapiro L, Honig B. Cell-to-cell contact and extracellular matrix Current Opinion in Cell Biology. 19: 493-494. DOI: 10.1016/J.Ceb.2007.09.009  0.494
2006 Patel SD, Ciatto C, Chen CP, Bahna F, Rajebhosale M, Arkus N, Schieren I, Jessell TM, Honig B, Price SR, Shapiro L. Type II cadherin ectodomain structures: implications for classical cadherin specificity. Cell. 124: 1255-68. PMID 16564015 DOI: 10.1016/J.Cell.2005.12.046  0.692
2005 Gorman J, Shapiro L. Crystal structures of the tryptophan repressor binding protein WrbA and complexes with flavin mononucleotide Protein Science. 14: 3004-3012. PMID 16322580 DOI: 10.1110/Ps.051680805  0.415
2005 Mancia F, Shapiro L. ADAM and Eph: How Ephrin-Signaling Cells Become Detached Cell. 123: 185-187. PMID 16239135 DOI: 10.1016/J.Cell.2005.10.004  0.305
2005 Bonanno JB, Almo SC, Bresnick A, Chance MR, Fiser A, Swaminathan S, Jiang J, Studier FW, Shapiro L, Lima CD, Gaasterland TM, Sali A, Bain K, Feil I, Gao X, et al. New York-Structural GenomiX Research Consortium (NYSGXRC): a large scale center for the protein structure initiative. Journal of Structural and Functional Genomics. 6: 225-32. PMID 16211523 DOI: 10.1007/S10969-005-6827-0  0.309
2005 Chen CP, Posy S, Ben-Shaul A, Shapiro L, Honig BH. Specificity of cell-cell adhesion by classical cadherins: Critical role for low-affinity dimerization through beta-strand swapping. Proceedings of the National Academy of Sciences of the United States of America. 102: 8531-6. PMID 15937105 DOI: 10.1073/Pnas.0503319102  0.62
2004 Gorman J, Shapiro L. Structure of serine acetyltransferase from Haemophilus influenzae Rd. Acta Crystallographica Section D-Biological Crystallography. 60: 1600-1605. PMID 15333931 DOI: 10.1107/S0907444904015240  0.366
2004 Mancia F, Patel SD, Rajala MW, Scherer PE, Nemes A, Schieren I, Hendrickson WA, Shapiro L. Optimization of protein production in mammalian cells with a coexpressed fluorescent marker Structure. 12: 1355-1360. PMID 15296729 DOI: 10.1016/J.Str.2004.06.012  0.696
2004 Patel SD, Rajala MW, Rossetti L, Scherer PE, Shapiro L. Disulfide-dependent multimeric assembly of resistin family hormones. Science (New York, N.Y.). 304: 1154-8. PMID 15155948 DOI: 10.1126/Science.1093466  0.601
2004 Jahoda CA, Kljuic A, O'Shaughnessy R, Crossley N, Whitehouse CJ, Robinson M, Reynolds AJ, Demarchez M, Porter RM, Shapiro L, Christiano AM. The lanceolate hair rat phenotype results from a missense mutation in a calcium coordinating site of the desmoglein 4 gene. Genomics. 83: 747-56. PMID 15081105 DOI: 10.1016/J.Ygeno.2003.11.015  0.332
2004 Gogos A, Gorman J, Shapiro L. Structure of Escherichia coli YfdW, a type III CoA transferase. Acta Crystallographica. Section D, Biological Crystallography. 60: 507-11. PMID 14993676 DOI: 10.1107/S0907444904000034  0.39
2004 Carroll K, Gomez C, Shapiro L. Tubby proteins: the plot thickens. Nature Reviews Molecular Cell Biology. 5: 55-64. PMID 14708010 DOI: 10.1038/Nrm1278  0.313
2003 Patel SD, Chen CP, Bahna F, Honig B, Shapiro L. Cadherin-mediated cell-cell adhesion: sticking together as a family. Current Opinion in Structural Biology. 13: 690-8. PMID 14675546 DOI: 10.1016/J.Sbi.2003.10.007  0.718
2003 Gogos A, Mu H, Bahna F, Gomez CA, Shapiro L. Crystal structure of YdcE protein from Bacillus subtilis. Proteins. 53: 320-2. PMID 14517982 DOI: 10.1002/Prot.10457  0.31
2002 Gogos A, Shapiro L. Large conformational changes in the catalytic cycle of glutathione synthase. Structure (London, England : 1993). 10: 1669-76. PMID 12467574 DOI: 10.1016/S0969-2126(02)00906-1  0.338
2002 Boggon TJ, Murray J, Chappuis-Flament S, Wong E, Gumbiner BM, Shapiro L. C-cadherin ectodomain structure and implications for cell adhesion mechanisms. Science (New York, N.Y.). 296: 1308-13. PMID 11964443 DOI: 10.1126/Science.1071559  0.64
2001 Santagata S, Boggon TJ, Baird CL, Gomez CA, Zhao J, Shan WS, Myszka DG, Shapiro L. G-protein signaling through tubby proteins. Science (New York, N.Y.). 292: 2041-50. PMID 11375483 DOI: 10.1126/Science.1061233  0.608
2000 Boggon TJ, Shapiro L. Screening for phasing atoms in protein crystallography Structure. 8. PMID 10903954 DOI: 10.1016/S0969-2126(00)00168-4  0.511
2000 Shan WS, Tanaka H, Phillips GR, Arndt K, Yoshida M, Colman DR, Shapiro L. Functional cis-heterodimers of N- and R-cadherins. The Journal of Cell Biology. 148: 579-90. PMID 10662782 DOI: 10.1083/Jcb.148.3.579  0.349
2000 Boggon TJ, Shan WS, Santagata S, Myers SC, Shapiro L. Implication of Tubby Proteins as Transcription Factors by Structure-Based Functional Analysis Acta Crystallographica Section A. 56: 263-263. DOI: 10.1107/S0108767300025642  0.57
1999 Shan WS, Koch A, Murray J, Colman DR, Shapiro L. The adhesive binding site of cadherins revisited. Biophysical Chemistry. 82: 157-63. PMID 10631798 DOI: 10.1016/S0301-4622(99)00115-5  0.41
1999 Boggon TJ, Shan WS, Santagata S, Myers SC, Shapiro L. Implication of tubby proteins as transcription factors by structure-based functional analysis. Science (New York, N.Y.). 286: 2119-25. PMID 10591637 DOI: 10.1126/Science.286.5447.2119  0.603
1999 Shapiro L, Colman DR. The diversity of cadherins and implications for a synaptic adhesive code in the CNS. Neuron. 23: 427-30. PMID 10433255 DOI: 10.1016/S0896-6273(00)80796-5  0.369
1998 Shapiro L, Colman DR. Structural biology of cadherins in the nervous system. Current Opinion in Neurobiology. 8: 593-9. PMID 9811622 DOI: 10.1016/S0959-4388(98)80086-X  0.378
1998 Tamura K, Shan WS, Hendrickson WA, Colman DR, Shapiro L. Structure-function analysis of cell adhesion by neural (N-) cadherin. Neuron. 20: 1153-63. PMID 9655503 DOI: 10.1016/S0896-6273(00)80496-1  0.581
1998 Shapiro L, Scherer PE. The crystal structure of a complement-1q family protein suggests an evolutionary link to tumor necrosis factor. Current Biology : Cb. 8: 335-8. PMID 9512423 DOI: 10.1016/S0960-9822(98)70133-2  0.361
1996 Shapiro L, Doyle JP, Hensley P, Colman DR, Hendrickson WA. Crystal structure of the extracellular domain from P0, the major structural protein of peripheral nerve myelin. Neuron. 17: 435-49. PMID 8816707 DOI: 10.1016/S0896-6273(00)80176-2  0.536
1995 Shapiro L, Fannon AM, Kwong PD, Thompson A, Lehmann MS, Grübel G, Legrand JF, Als-Nielsen J, Colman DR, Hendrickson WA. Structural basis of cell-cell adhesion by cadherins. Nature. 374: 327-37. PMID 7885471 DOI: 10.1038/374327A0  0.589
1995 Shapiro L, Kwong PD, Fannon AM, Colman DR, Hendrickson WA. Considerations on the folding topology and evolutionary origin of cadherin domains. Proceedings of the National Academy of Sciences of the United States of America. 92: 6793-7. PMID 7624321 DOI: 10.1073/Pnas.92.15.6793  0.569
1985 Lewis W, Beckenstein K, Shapiro L, Puszkin S. Doxorubicin and covalently crosslinked doxorubicin derivatives binding to purified cardiac thin-filament proteins in vitro. Experimental and Molecular Pathology. 43: 64-73. PMID 4007142 DOI: 10.1016/0014-4800(85)90055-3  0.345
1982 Lisanti MP, Shapiro LS, Moskowitz N, Hua EL, Puszkin S, Schook W. Isolation and preliminary characterization of clathrin-associated proteins European Journal of Biochemistry. 125: 463-470. PMID 7117245 DOI: 10.1111/J.1432-1033.1982.Tb06706.X  0.346
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