| Year |
Citation |
Score |
| 2024 |
Kim MJ, Kim S, Reinheckel T, Krainc D. Inhibition of cysteine protease cathepsin Lincreases the level and activity of lysosomal glucocerebrosidase. Jci Insight. 9. PMID 38329128 DOI: 10.1172/jci.insight.169594 |
0.339 |
|
| 2024 |
Brooker SM, Naylor GE, Krainc D. Cell biology of Parkinson's disease: Mechanisms of synaptic, lysosomal, and mitochondrial dysfunction. Current Opinion in Neurobiology. 85: 102841. PMID 38306948 DOI: 10.1016/j.conb.2024.102841 |
0.34 |
|
| 2023 |
Song P, Peng W, Sauve V, Fakih R, Xie Z, Ysselstein D, Krainc T, Wong YC, Mencacci NE, Savas JN, Surmeier DJ, Gehring K, Krainc D. Parkinson's disease-linked parkin mutation disrupts recycling of synaptic vesicles in human dopaminergic neurons. Neuron. PMID 37716354 DOI: 10.1016/j.neuron.2023.08.018 |
0.375 |
|
| 2023 |
Peng W, Schröder LF, Song P, Wong YC, Krainc D. Parkin regulates amino acid homeostasis at mitochondria-lysosome (M/L) contact sites in Parkinson's disease. Science Advances. 9: eadh3347. PMID 37467322 DOI: 10.1126/sciadv.adh3347 |
0.341 |
|
| 2023 |
Chatterjee D, Krainc D. Mechanisms of Glucocerebrosidase Dysfunction in Parkinson's Disease. Journal of Molecular Biology. 168023. PMID 36828270 DOI: 10.1016/j.jmb.2023.168023 |
0.314 |
|
| 2022 |
Wong YC, Kim S, Cisneros J, Molakal CG, Song P, Lubbe SJ, Krainc D. Mid51/Fis1 mitochondrial oligomerization complex drives lysosomal untethering and network dynamics. The Journal of Cell Biology. 221. PMID 36044022 DOI: 10.1083/jcb.202206140 |
0.466 |
|
| 2022 |
Kim S, Coukos R, Gao F, Krainc D. Dysregulation of organelle membrane contact sites in neurological diseases. Neuron. PMID 35561676 DOI: 10.1016/j.neuron.2022.04.020 |
0.487 |
|
| 2021 |
Burbulla LF, Zheng J, Song P, Jiang W, Johnson ME, Brundin P, Krainc D. Direct targeting of wild-type glucocerebrosidase by antipsychotic quetiapine improves pathogenic phenotypes in Parkinson's disease models. Jci Insight. 6. PMID 34622801 DOI: 10.1172/jci.insight.148649 |
0.323 |
|
| 2021 |
Brooker SM, Krainc D. Glucocerebrosidase dysfunction in neurodegenerative disease. Essays in Biochemistry. PMID 34528667 DOI: 10.1042/EBC20210018 |
0.399 |
|
| 2021 |
Kim S, Wong YC, Gao F, Krainc D. Dysregulation of mitochondria-lysosome contacts by GBA1 dysfunction in dopaminergic neuronal models of Parkinson's disease. Nature Communications. 12: 1807. PMID 33753743 DOI: 10.1038/s41467-021-22113-3 |
0.555 |
|
| 2021 |
Charif M, Wong YC, Kim S, Guichet A, Vignal C, Zanlonghi X, Bensaid P, Procaccio V, Bonneau D, Amati-Bonneau P, Reynier P, Krainc D, Lenaers G. Dominant mutations in MIEF1 affect mitochondrial dynamics and cause a singular late onset optic neuropathy. Molecular Neurodegeneration. 16: 12. PMID 33632269 DOI: 10.1186/s13024-021-00431-w |
0.465 |
|
| 2020 |
Minakaki G, Krainc D, Burbulla LF. The Convergence of Alpha-Synuclein, Mitochondrial, and Lysosomal Pathways in Vulnerability of Midbrain Dopaminergic Neurons in Parkinson's Disease. Frontiers in Cell and Developmental Biology. 8: 580634. PMID 33381501 DOI: 10.3389/fcell.2020.580634 |
0.346 |
|
| 2020 |
Tsunemi T, Ishiguro Y, Yoroisaka A, Valdez C, Miyamoto K, Ishikawa K, Saiki S, Akamatsu W, Hattori N, Krainc D. Astrocytes Protect Human Dopaminergic Neurons from α-Synuclein Accumulation and Propagation. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. PMID 33046546 DOI: 10.1523/JNEUROSCI.0954-20.2020 |
0.322 |
|
| 2020 |
Boussaad I, Obermaier CD, Hanss Z, Bobbili DR, Bolognin S, Glaab E, Wołyńska K, Weisschuh N, De Conti L, May C, Giesert F, Grossmann D, Lambert A, Kirchen S, Biryukov M, ... ... Krainc D, et al. A patient-based model of RNA mis-splicing uncovers treatment targets in Parkinson's disease. Science Translational Medicine. 12. PMID 32908004 DOI: 10.1126/Scitranslmed.Aau3960 |
0.475 |
|
| 2020 |
Peng W, Wong YC, Krainc D. Mitochondria-lysosome contacts regulate mitochondrial Ca dynamics via lysosomal TRPML1. Proceedings of the National Academy of Sciences of the United States of America. PMID 32703809 DOI: 10.1073/Pnas.2003236117 |
0.307 |
|
| 2020 |
Marotta N, Kim S, Krainc D. Organoid and pluripotent stem cells in Parkinson's disease modeling: an expert view on their value to drug discovery. Expert Opinion On Drug Discovery. 1-15. PMID 31899983 DOI: 10.1080/17460441.2020.1703671 |
0.591 |
|
| 2019 |
Ysselstein D, Nguyen M, Young TJ, Severino A, Schwake M, Merchant K, Krainc D. LRRK2 kinase activity regulates lysosomal glucocerebrosidase in neurons derived from Parkinson's disease patients. Nature Communications. 10: 5570. PMID 31804465 DOI: 10.1038/S41467-019-13413-W |
0.455 |
|
| 2019 |
Burbulla LF, Jeon S, Zheng J, Song P, Silverman RB, Krainc D. A modulator of wild-type glucocerebrosidase improves pathogenic phenotypes in dopaminergic neuronal models of Parkinson's disease. Science Translational Medicine. 11. PMID 31619543 DOI: 10.1126/Scitranslmed.Aau6870 |
0.445 |
|
| 2019 |
Valdez C, Ysselstein D, Young TJ, Zheng J, Krainc D. Progranulin mutations result in impaired processing of prosaposin and reduced glucocerebrosidase activity. Human Molecular Genetics. PMID 31600775 DOI: 10.1093/Hmg/Ddz229 |
0.395 |
|
| 2019 |
Wong YC, Luk K, Purtell K, Burke Nanni S, Stoessl AJ, Trudeau LE, Yue Z, Krainc D, Oertel W, Obeso JA, Volpicelli-Daley LA. Neuronal vulnerability in Parkinson disease: Should the focus be on axons and synaptic terminals? Movement Disorders : Official Journal of the Movement Disorder Society. PMID 31483900 DOI: 10.1002/Mds.27823 |
0.433 |
|
| 2019 |
Burbulla LF, Krainc D. The role of dopamine in the pathogenesis of GBA1-linked Parkinson's disease. Neurobiology of Disease. 132: 104545. PMID 31351996 DOI: 10.1016/J.Nbd.2019.104545 |
0.441 |
|
| 2019 |
Burbulla LF, Krainc D. The role of dopamine in the pathogenesis of GBA1-linked Parkinson's disease. Neurobiology of Disease. 132: 104545. PMID 31351996 DOI: 10.1016/j.nbd.2019.104545 |
0.338 |
|
| 2019 |
Wong YC, Peng W, Krainc D. Lysosomal Regulation of Inter-mitochondrial Contact Fate and Motility in Charcot-Marie-Tooth Type 2. Developmental Cell. PMID 31231042 DOI: 10.1016/J.Devcel.2019.05.033 |
0.328 |
|
| 2019 |
Peng W, Minakaki G, Nguyen M, Krainc D. Preserving Lysosomal Function in the Aging Brain: Insights from Neurodegeneration. Neurotherapeutics : the Journal of the American Society For Experimental Neurotherapeutics. PMID 31183763 DOI: 10.1007/S13311-019-00742-3 |
0.376 |
|
| 2019 |
Tsunemi T, Perez-Rosello T, Ishiguro Y, Yoroisaka A, Jeon S, Hamada K, Krishna Vangipuram Suresh M, Wong YC, Xie Z, Akamatsu W, Mazzulli JR, Surmeier DJ, Hattori N, Krainc D. Increased lysosomal exocytosis induced by lysosomal Ca channel agonists protects human dopaminergic neurons from α-synuclein toxicity. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. PMID 31097622 DOI: 10.1523/Jneurosci.3085-18.2019 |
0.452 |
|
| 2019 |
Wong YC, Kim S, Peng W, Krainc D. Regulation and Function of Mitochondria-Lysosome Membrane Contact Sites in Cellular Homeostasis. Trends in Cell Biology. PMID 30898429 DOI: 10.1016/J.Tcb.2019.02.004 |
0.521 |
|
| 2019 |
Ysselstein D, Shulman JM, Krainc D. Emerging links between pediatric lysosomal storage diseases and adult parkinsonism. Movement Disorders : Official Journal of the Movement Disorder Society. PMID 30726573 DOI: 10.1002/Mds.27631 |
0.38 |
|
| 2019 |
Zheng J, Jeon S, Jiang W, Burbulla LF, Ysselstein D, Oevel K, Krainc D, Silverman RB. Conversion of Quinazoline Modulators from Inhibitors to Activators of β-Glucocerebrosidase. Journal of Medicinal Chemistry. PMID 30645117 DOI: 10.1021/Acs.Jmedchem.8B01294 |
0.431 |
|
| 2019 |
Kim S, Wong Y, Krainc D. Misregulation of mitochondria–lysosome contact sites in glucocerebrosidase (GBA) Parkinson's patient neurons Ibro Reports. 6: S557. DOI: 10.1016/J.Ibror.2019.07.1751 |
0.363 |
|
| 2018 |
Nguyen M, Wong YC, Ysselstein D, Severino A, Krainc D. Synaptic, Mitochondrial, and Lysosomal Dysfunction in Parkinson's Disease. Trends in Neurosciences. PMID 30509690 DOI: 10.1016/J.Tins.2018.11.001 |
0.435 |
|
| 2018 |
Trajkovic K, Krainc D. Novel Approach to Tracking Mutant Huntingtin in Biosamples. Trends in Molecular Medicine. 24: 978-981. PMID 30509361 DOI: 10.1016/J.Molmed.2018.10.002 |
0.428 |
|
| 2018 |
Trajkovic K, Krainc D. Novel Approach to Tracking Mutant Huntingtin in Biosamples. Trends in Molecular Medicine. 24: 978-981. PMID 30509361 DOI: 10.1016/j.molmed.2018.10.002 |
0.322 |
|
| 2018 |
Seibler P, Burbulla LF, Dulovic M, Zittel S, Heine J, Schmidt T, Rudolph F, Westenberger A, Rakovic A, Münchau A, Krainc D, Klein C. Iron overload is accompanied by mitochondrial and lysosomal dysfunction in WDR45 mutant cells. Brain : a Journal of Neurology. PMID 30169597 DOI: 10.1093/Brain/Awy230 |
0.35 |
|
| 2018 |
Causevic M, Dominko K, Malnar M, Vidatic L, Cermak S, Pigoni M, Kuhn PH, Colombo A, Havas D, Flunkert S, McDonald J, Gunnersen JM, Hutter-Paier B, Tahirovic S, Windisch M, ... Krainc D, et al. BACE1-cleavage of Sez6 and Sez6L is elevated in Niemann-Pick type C disease mouse brains. Plos One. 13: e0200344. PMID 29979789 DOI: 10.1371/Journal.Pone.0200344 |
0.403 |
|
| 2018 |
Nguyen M, Krainc D. LRRK2 phosphorylation of auxilin mediates synaptic defects in dopaminergic neurons from patients with Parkinson's disease. Proceedings of the National Academy of Sciences of the United States of America. PMID 29735704 DOI: 10.1073/Pnas.1717590115 |
0.415 |
|
| 2018 |
Zheng J, Chen L, Skinner OS, Ysselstein D, Remis J, Lansbury P, Skerlj R, Mrosek M, Heunisch U, Krapp S, Charrow J, Schwake M, Kelleher NL, Silverman RB, Krainc D. β-Glucocerebrosidase modulators promote dimerization of β-glucocerebrosidase and reveal an allosteric binding site. Journal of the American Chemical Society. PMID 29676907 DOI: 10.1021/Jacs.7B13003 |
0.361 |
|
| 2018 |
Kim MJ, Jeon S, Burbulla LF, Krainc D. Acid ceramidase inhibition ameliorates α-synuclein accumulation upon loss of GBA1 function. Human Molecular Genetics. PMID 29579237 DOI: 10.1093/Hmg/Ddy105 |
0.427 |
|
| 2018 |
Gauthier J, Meijer IA, Lessel D, Mencacci NE, Krainc D, Hempel M, Tsiakas K, Prokisch H, Rossignol E, Helm MH, Rodan LH, Karamchandani J, Carecchio M, Lubbe SJ, Telegrafi A, et al. Recessive mutations in VPS13D cause childhood-onset movement disorders. Annals of Neurology. PMID 29518281 DOI: 10.1002/Ana.25204 |
0.356 |
|
| 2018 |
Wong YC, Ysselstein D, Krainc D. Mitochondria-lysosome contacts regulate mitochondrial fission via RAB7 GTP hydrolysis. Nature. PMID 29364868 DOI: 10.1038/Nature25486 |
0.349 |
|
| 2018 |
Simuni T, Krainc D. High priority publications on Parkinson's disease in 2017. The Lancet. Neurology. 17: 8-10. PMID 29263010 DOI: 10.1016/S1474-4422(17)30416-7 |
0.367 |
|
| 2017 |
Al-Ramahi I, Giridharan SSP, Chen YC, Patnaik S, Safren N, Hasegawa J, de Haro M, Wagner Gee AK, Titus SA, Jeong H, Clarke J, Krainc D, Zheng W, Irvine RF, Barmada S, et al. Inhibition of PIP4Kγ ameliorates the pathological effects of mutant huntingtin protein. Elife. 6. PMID 29256861 DOI: 10.7554/Elife.29123 |
0.463 |
|
| 2017 |
Conrad KS, Cheng TW, Ysselstein D, Heybrock S, Hoth LR, Chrunyk BA, Am Ende CW, Krainc D, Schwake M, Saftig P, Liu S, Qiu X, Ehlers MD. Lysosomal integral membrane protein-2 as a phospholipid receptor revealed by biophysical and cellular studies. Nature Communications. 8: 1908. PMID 29199275 DOI: 10.1038/S41467-017-02044-8 |
0.307 |
|
| 2017 |
Stojkovska I, Krainc D, Mazzulli JR. Molecular mechanisms of α-synuclein and GBA1 in Parkinson's disease. Cell and Tissue Research. PMID 29064079 DOI: 10.1007/S00441-017-2704-Y |
0.462 |
|
| 2017 |
Valdez C, Wong YC, Schwake M, Bu G, Wszolek ZK, Krainc D. Progranulin-mediated deficiency of cathepsin D results in FTD and NCL-like phenotypes in neurons derived from FTD patients. Human Molecular Genetics. PMID 29036611 DOI: 10.1093/Hmg/Ddx364 |
0.382 |
|
| 2017 |
Völker JM, Dergai M, Abriata LA, Mingard Y, Ysselstein D, Krainc D, Dal Peraro M, Fischer von Mollard G, Fasshauer D, Koliwer J, Schwake M. Functional assays for the assessment of the pathogenicity of variants of GOSR2, an ER-to-Golgi SNARE involved in progressive myoclonus epilepsies. Disease Models & Mechanisms. 10: 1391-1398. PMID 28982678 DOI: 10.1242/Dmm.029132 |
0.312 |
|
| 2017 |
Shamir R, Klein C, Amar D, Vollstedt EJ, Bonin M, Usenovic M, Wong YC, Maver A, Poths S, Safer H, Corvol JC, Lesage S, Lavi O, Deuschl G, Kuhlenbaeumer G, ... ... Krainc D, et al. Analysis of blood-based gene expression in idiopathic Parkinson disease. Neurology. PMID 28916538 DOI: 10.1212/Wnl.0000000000004516 |
0.362 |
|
| 2017 |
Burbulla LF, Song P, Mazzulli JR, Zampese E, Wong YC, Jeon S, Santos DP, Blanz J, Obermaier CD, Strojny C, Savas JN, Kiskinis E, Zhuang X, Krüger R, Surmeier DJ, ... Krainc D, et al. Dopamine oxidation mediates mitochondrial and lysosomal dysfunction in Parkinson's disease. Science (New York, N.Y.). PMID 28882997 DOI: 10.1126/Science.Aam9080 |
0.446 |
|
| 2017 |
Trajkovic K, Jeong H, Krainc D. Mutant huntingtin is secreted via a late endosomal/lysosomal unconventional secretory pathway. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. PMID 28821645 DOI: 10.1523/Jneurosci.0118-17.2017 |
0.404 |
|
| 2017 |
Wong YC, Krainc D. α-synuclein toxicity in neurodegeneration: mechanism and therapeutic strategies. Nature Medicine. 23: 1-13. PMID 28170377 DOI: 10.1038/Nm.4269 |
0.412 |
|
| 2017 |
Kim MJ, Deng HX, Wong YC, Siddique T, Krainc D. The Parkinson's disease-linked protein TMEM230 is required for Rab8a-mediated secretory vesicle trafficking and retromer trafficking. Human Molecular Genetics. PMID 28115417 DOI: 10.1093/Hmg/Ddw413 |
0.417 |
|
| 2017 |
Mc Donald JM, Krainc D. Lysosomal Proteins as a Therapeutic Target in Neurodegeneration. Annual Review of Medicine. 68: 445-458. PMID 28099085 DOI: 10.1146/Annurev-Med-050715-104432 |
0.402 |
|
| 2016 |
Chung SY, Kishinevsky S, Mazzulli JR, Graziotto J, Mrejeru A, Mosharov EV, Puspita L, Valiulahi P, Sulzer D, Milner TA, Taldone T, Krainc D, Studer L, Shim JW. Parkin and PINK1 Patient iPSC-Derived Midbrain Dopamine Neurons Exhibit Mitochondrial Dysfunction and α-Synuclein Accumulation. Stem Cell Reports. PMID 27641647 DOI: 10.1016/J.Stemcr.2016.08.012 |
0.46 |
|
| 2016 |
Wong YC, Krainc D. Lysosomal trafficking defects link Parkinson's disease with Gaucher's disease. Movement Disorders : Official Journal of the Movement Disorder Society. PMID 27619775 DOI: 10.1002/Mds.26802 |
0.458 |
|
| 2016 |
Hsieh CH, Shaltouki A, Gonzalez AE, Bettencourt da Cruz A, Burbulla LF, St Lawrence E, Schüle B, Krainc D, Palmer TD, Wang X. Functional Impairment in Miro Degradation and Mitophagy Is a Shared Feature in Familial and Sporadic Parkinson's Disease. Cell Stem Cell. PMID 27618216 DOI: 10.1016/J.Stem.2016.08.002 |
0.443 |
|
| 2016 |
Zheng J, Chen L, Schwake M, Silverman RB, Krainc D. Design and Synthesis of Potent Quinazolines as Selective β-Glucocerebrosidase Modulators. Journal of Medicinal Chemistry. PMID 27598312 DOI: 10.1021/Acs.Jmedchem.6B00930 |
0.388 |
|
| 2016 |
Burbulla LF, Beaumont KG, Mrksich M, Krainc D. Human Neuron Cultures: Micropatterning Facilitates the Long-Term Growth and Analysis of iPSC-Derived Individual Human Neurons and Neuronal Networks (Adv. Healthcare Mater. 15/2016). Advanced Healthcare Materials. 5: 1893. PMID 27511952 DOI: 10.1002/Adhm.201670079 |
0.316 |
|
| 2016 |
Mazzulli JR, Zunke F, Tsunemi T, Toker NJ, Jeon S, Burbulla LF, Patnaik S, Sidransky E, Marugan JJ, Sue CM, Krainc D. Activation of β-Glucocerebrosidase Reduces Pathological α-Synuclein and Restores Lysosomal Function in Parkinson's Patient Midbrain Neurons. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 36: 7693-706. PMID 27445146 DOI: 10.1523/Jneurosci.0628-16.2016 |
0.431 |
|
| 2016 |
Deng HX, Shi Y, Yang Y, Ahmeti KB, Miller N, Huang C, Cheng L, Zhai H, Deng S, Nuytemans K, Corbett NJ, Kim MJ, Deng H, Tang B, Yang Z, ... ... Krainc D, et al. Identification of TMEM230 mutations in familial Parkinson's disease. Nature Genetics. PMID 27270108 DOI: 10.1038/Ng.3589 |
0.46 |
|
| 2016 |
Burbulla LF, Beaumont KG, Mrksich M, Krainc D. Micropatterning Facilitates the Long-Term Growth and Analysis of iPSC-Derived Individual Human Neurons and Neuronal Networks. Advanced Healthcare Materials. PMID 27108930 DOI: 10.1002/Adhm.201500900 |
0.347 |
|
| 2016 |
Zunke F, Andresen L, Wesseler S, Groth J, Arnold P, Rothaug M, Mazzulli JR, Krainc D, Blanz J, Saftig P, Schwake M. Characterization of the complex formed by β-glucocerebrosidase and the lysosomal integral membrane protein type-2. Proceedings of the National Academy of Sciences of the United States of America. PMID 27001828 DOI: 10.1073/Pnas.1514005113 |
0.397 |
|
| 2016 |
Song P, Trajkovic K, Tsunemi T, Krainc D. Parkin Modulates Endosomal Organization and Function of the Endo-Lysosomal Pathway. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 36: 2425-37. PMID 26911690 DOI: 10.1523/Jneurosci.2569-15.2016 |
0.443 |
|
| 2016 |
Domingo A, Amar D, Grütz K, Lee LV, Rosales R, Brüggemann N, Jamora RD, Cutiongco-Dela Paz E, Rolfs A, Dressler D, Walter U, Krainc D, Lohmann K, Shamir R, Klein C, et al. Evidence of TAF1 dysfunction in peripheral models of X-linked dystonia-parkinsonism. Cellular and Molecular Life Sciences : Cmls. PMID 26879577 DOI: 10.1007/S00018-016-2159-4 |
0.338 |
|
| 2016 |
Mazzulli JR, Zunke F, Isacson O, Studer L, Krainc D. α-Synuclein-induced lysosomal dysfunction occurs through disruptions in protein trafficking in human midbrain synucleinopathy models. Proceedings of the National Academy of Sciences of the United States of America. PMID 26839413 DOI: 10.1073/Pnas.1520335113 |
0.452 |
|
| 2016 |
Mazzulli JR, Burbulla LF, Krainc D, Ischiropoulos H. Detection of Free and Protein-Bound ortho-Quinones by Near-Infrared Fluorescence. Analytical Chemistry. 88: 2399-405. PMID 26813311 DOI: 10.1021/Acs.Analchem.5B04420 |
0.364 |
|
| 2016 |
Klionsky DJ, Abdelmohsen K, Abe A, Abedin MJ, Abeliovich H, Acevedo Arozena A, Adachi H, Adams CM, Adams PD, Adeli K, Adhihetty PJ, Adler SG, Agam G, Agarwal R, Aghi MK, ... ... Krainc D, et al. Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition). Autophagy. 12: 1-222. PMID 26799652 DOI: 10.1080/15548627.2015.1100356 |
0.303 |
|
| 2014 |
Tsunemi T, Hamada K, Krainc D. ATP13A2/PARK9 regulates secretion of exosomes and α-synuclein. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 34: 15281-7. PMID 25392495 DOI: 10.1523/Jneurosci.1629-14.2014 |
0.373 |
|
| 2014 |
Rothaug M, Zunke F, Mazzulli JR, Schweizer M, Altmeppen H, Lüllmann-Rauch R, Kallemeijn WW, Gaspar P, Aerts JM, Glatzel M, Saftig P, Krainc D, Schwake M, Blanz J. LIMP-2 expression is critical for β-glucocerebrosidase activity and α-synuclein clearance. Proceedings of the National Academy of Sciences of the United States of America. 111: 15573-8. PMID 25316793 DOI: 10.1073/Pnas.1405700111 |
0.443 |
|
| 2014 |
Knight AL, Yan X, Hamamichi S, Ajjuri RR, Mazzulli JR, Zhang MW, Daigle JG, Zhang S, Borom AR, Roberts LR, Lee SK, DeLeon SM, Viollet-Djelassi C, Krainc D, O'Donnell JM, et al. The glycolytic enzyme, GPI, is a functionally conserved modifier of dopaminergic neurodegeneration in Parkinson's models. Cell Metabolism. 20: 145-57. PMID 24882066 DOI: 10.1016/J.Cmet.2014.04.017 |
0.397 |
|
| 2014 |
Sybertz E, Krainc D. Development of targeted therapies for Parkinson's disease and related synucleinopathies. Journal of Lipid Research. 55: 1996-2003. PMID 24668939 DOI: 10.1194/Jlr.R047381 |
0.413 |
|
| 2014 |
Bega D, Krainc D. Long-term clinical outcomes after fetal cell transplantation in parkinson disease: implications for the future of cell therapy. Jama. 311: 617-8. PMID 24519302 DOI: 10.1001/Jama.2013.285516 |
0.318 |
|
| 2014 |
Tsunemi T, Krainc D. Zn²⁺ dyshomeostasis caused by loss of ATP13A2/PARK9 leads to lysosomal dysfunction and alpha-synuclein accumulation. Human Molecular Genetics. 23: 2791-801. PMID 24334770 DOI: 10.1093/Hmg/Ddt572 |
0.38 |
|
| 2013 |
Xiang Z, Krainc D. Pharmacological upregulation of PGC1α in oligodendrocytes: implications for Huntington's Disease. Journal of Huntington's Disease. 2: 101-5. PMID 25063433 DOI: 10.3233/Jhd-130046 |
0.333 |
|
| 2013 |
Miller JD, Ganat YM, Kishinevsky S, Bowman RL, Liu B, Tu EY, Mandal PK, Vera E, Shim JW, Kriks S, Taldone T, Fusaki N, Tomishima MJ, Krainc D, Milner TA, et al. Human iPSC-based modeling of late-onset disease via progerin-induced aging. Cell Stem Cell. 13: 691-705. PMID 24315443 DOI: 10.1016/J.Stem.2013.11.006 |
0.403 |
|
| 2013 |
Chung CY, Khurana V, Auluck PK, Tardiff DF, Mazzulli JR, Soldner F, Baru V, Lou Y, Freyzon Y, Cho S, Mungenast AE, Muffat J, Mitalipova M, Pluth MD, Jui NT, ... ... Krainc D, et al. Identification and rescue of α-synuclein toxicity in Parkinson patient-derived neurons. Science (New York, N.Y.). 342: 983-7. PMID 24158904 DOI: 10.1126/Science.1245296 |
0.478 |
|
| 2013 |
Vashishtha M, Ng CW, Yildirim F, Gipson TA, Kratter IH, Bodai L, Song W, Lau A, Labadorf A, Vogel-Ciernia A, Troncosco J, Ross CA, Bates GP, Krainc D, Sadri-Vakili G, et al. Targeting H3K4 trimethylation in Huntington disease. Proceedings of the National Academy of Sciences of the United States of America. 110: E3027-36. PMID 23872847 DOI: 10.1073/Pnas.1311323110 |
0.398 |
|
| 2013 |
Klein C, Krainc D. Glucocerebrosidase mutations: tipping point toward Parkinson disease and dementia? Jama Neurology. 70: 686-8. PMID 23588619 DOI: 10.1001/Jamaneurol.2013.87 |
0.359 |
|
| 2013 |
Schultheis PJ, Fleming SM, Clippinger AK, Lewis J, Tsunemi T, Giasson B, Dickson DW, Mazzulli JR, Bardgett ME, Haik KL, Ekhator O, Chava AK, Howard J, Gannon M, Hoffman E, ... ... Krainc D, et al. Atp13a2-deficient mice exhibit neuronal ceroid lipofuscinosis, limited α-synuclein accumulation and age-dependent sensorimotor deficits. Human Molecular Genetics. 22: 2067-82. PMID 23393156 DOI: 10.1093/Hmg/Ddt057 |
0.449 |
|
| 2013 |
Rakovic A, Shurkewitsch K, Seibler P, Grünewald A, Zanon A, Hagenah J, Krainc D, Klein C. Phosphatase and tensin homolog (PTEN)-induced putative kinase 1 (PINK1)-dependent ubiquitination of endogenous Parkin attenuates mitophagy: study in human primary fibroblasts and induced pluripotent stem cell-derived neurons. The Journal of Biological Chemistry. 288: 2223-37. PMID 23212910 DOI: 10.1074/Jbc.M112.391680 |
0.425 |
|
| 2013 |
Li X, Uemura K, Hashimoto T, Nasser-Ghodsi N, Arimon M, Lill CM, Palazzolo I, Krainc D, Hyman BT, Berezovska O. Neuronal activity and secreted amyloid β lead to altered amyloid β precursor protein and presenilin 1 interactions. Neurobiology of Disease. 50: 127-34. PMID 23064434 DOI: 10.1016/J.Nbd.2012.10.002 |
0.348 |
|
| 2013 |
Kumar KR, Ramirez A, Göbel A, Kresojević N, Svetel M, Lohmann K, M Sue C, Rolfs A, Mazzulli JR, Alcalay RN, Krainc D, Klein C, Kostic V, Grünewald A. Glucocerebrosidase mutations in a Serbian Parkinson's disease population. European Journal of Neurology : the Official Journal of the European Federation of Neurological Societies. 20: 402-5. PMID 22812582 DOI: 10.1111/J.1468-1331.2012.03817.X |
0.383 |
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| 2012 |
Cooper O, Seo H, Andrabi S, Guardia-Laguarta C, Graziotto J, Sundberg M, McLean JR, Carrillo-Reid L, Xie Z, Osborn T, Hargus G, Deleidi M, Lawson T, Bogetofte H, Perez-Torres E, ... ... Krainc D, et al. Pharmacological rescue of mitochondrial deficits in iPSC-derived neural cells from patients with familial Parkinson's disease. Science Translational Medicine. 4: 141ra90. PMID 22764206 DOI: 10.1126/Scitranslmed.3003985 |
0.434 |
|
| 2012 |
Usenovic M, Knight AL, Ray A, Wong V, Brown KR, Caldwell GA, Caldwell KA, Stagljar I, Krainc D. Identification of novel ATP13A2 interactors and their role in α-synuclein misfolding and toxicity. Human Molecular Genetics. 21: 3785-94. PMID 22645275 DOI: 10.1093/Hmg/Dds206 |
0.459 |
|
| 2012 |
Usenovic M, Krainc D. Lysosomal dysfunction in neurodegeneration: the role of ATP13A2/PARK9. Autophagy. 8: 987-8. PMID 22561922 DOI: 10.4161/Auto.20256 |
0.45 |
|
| 2012 |
Usenovic M, Tresse E, Mazzulli JR, Taylor JP, Krainc D. Deficiency of ATP13A2 leads to lysosomal dysfunction, α-synuclein accumulation, and neurotoxicity. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 32: 4240-6. PMID 22442086 DOI: 10.1523/Jneurosci.5575-11.2012 |
0.489 |
|
| 2012 |
Lim MA, Selak MA, Xiang Z, Krainc D, Neve RL, Kraemer BC, Watts JL, Kalb RG. Reduced activity of AMP-activated protein kinase protects against genetic models of motor neuron disease. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 32: 1123-41. PMID 22262909 DOI: 10.1523/Jneurosci.6554-10.2012 |
0.372 |
|
| 2012 |
Klein C, Krainc D. Movement disorders in 2011: Translating new research findings into clinical practice. Nature Reviews. Neurology. 8: 65-6. PMID 22187001 DOI: 10.1038/Nrneurol.2011.212 |
0.3 |
|
| 2012 |
Jiang M, Wang J, Fu J, Du L, Jeong H, West T, Xiang L, Peng Q, Hou Z, Cai H, Seredenina T, Arbez N, Zhu S, Sommers K, Qian J, ... ... Krainc D, et al. Neuroprotective role of Sirt1 in mammalian models of Huntington's disease through activation of multiple Sirt1 targets. Nature Medicine. 18: 153-8. PMID 22179319 DOI: 10.1038/Nm.2558 |
0.456 |
|
| 2012 |
Jeong H, Cohen DE, Cui L, Supinski A, Savas JN, Mazzulli JR, Yates JR, Bordone L, Guarente L, Krainc D. Sirt1 mediates neuroprotection from mutant huntingtin by activation of the TORC1 and CREB transcriptional pathway. Nature Medicine. 18: 159-65. PMID 22179316 DOI: 10.1038/Nm.2559 |
0.432 |
|
| 2012 |
Graziotto JJ, Cao K, Collins FS, Krainc D. Rapamycin activates autophagy in Hutchinson-Gilford progeria syndrome: implications for normal aging and age-dependent neurodegenerative disorders. Autophagy. 8: 147-51. PMID 22170152 DOI: 10.4161/Auto.8.1.18331 |
0.319 |
|
| 2012 |
Palada V, Terzić J, Mazzulli J, Bwala G, Hagenah J, Peterlin B, Hung AY, Klein C, Krainc D. Histamine N-methyltransferase Thr105Ile polymorphism is associated with Parkinson's disease. Neurobiology of Aging. 33: 836.e1-3. PMID 21794955 DOI: 10.1016/J.Neurobiolaging.2011.06.015 |
0.353 |
|
| 2012 |
Mazzulli J, Krainc D. A Mechanistic Connection Between Gaucher Disease and the Synucleinopathies Molecular Genetics and Metabolism. 105: S46. DOI: 10.1016/J.Ymgme.2011.11.112 |
0.345 |
|
| 2011 |
Sadagurski M, Cheng Z, Rozzo A, Palazzolo I, Kelley GR, Dong X, Krainc D, White MF. IRS2 increases mitochondrial dysfunction and oxidative stress in a mouse model of Huntington disease. The Journal of Clinical Investigation. 121: 4070-81. PMID 21926467 DOI: 10.1172/Jci46305 |
0.382 |
|
| 2011 |
Cao K, Graziotto JJ, Blair CD, Mazzulli JR, Erdos MR, Krainc D, Collins FS. Rapamycin reverses cellular phenotypes and enhances mutant protein clearance in Hutchinson-Gilford progeria syndrome cells. Science Translational Medicine. 3: 89ra58. PMID 21715679 DOI: 10.1126/Scitranslmed.3002346 |
0.346 |
|
| 2011 |
Xiang Z, Valenza M, Cui L, Leoni V, Jeong HK, Brilli E, Zhang J, Peng Q, Duan W, Reeves SA, Cattaneo E, Krainc D. Peroxisome-proliferator-activated receptor gamma coactivator 1 α contributes to dysmyelination in experimental models of Huntington's disease. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 31: 9544-53. PMID 21715619 DOI: 10.1523/Jneurosci.1291-11.2011 |
0.33 |
|
| 2011 |
Mazzulli JR, Xu YH, Sun Y, Knight AL, McLean PJ, Caldwell GA, Sidransky E, Grabowski GA, Krainc D. Gaucher disease glucocerebrosidase and α-synuclein form a bidirectional pathogenic loop in synucleinopathies. Cell. 146: 37-52. PMID 21700325 DOI: 10.1016/J.Cell.2011.06.001 |
0.479 |
|
| 2011 |
Park JS, Mehta P, Cooper AA, Veivers D, Heimbach A, Stiller B, Kubisch C, Fung VS, Krainc D, Mackay-Sim A, Sue CM. Pathogenic effects of novel mutations in the P-type ATPase ATP13A2 (PARK9) causing Kufor-Rakeb syndrome, a form of early-onset parkinsonism. Human Mutation. 32: 956-64. PMID 21542062 DOI: 10.1002/Humu.21527 |
0.35 |
|
| 2011 |
Seibler P, Graziotto J, Jeong H, Simunovic F, Klein C, Krainc D. Mitochondrial Parkin recruitment is impaired in neurons derived from mutant PINK1 induced pluripotent stem cells. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 31: 5970-6. PMID 21508222 DOI: 10.1523/Jneurosci.4441-10.2011 |
0.455 |
|
| 2011 |
Klein C, Krainc D, Schlossmacher MG, Lang AE. Translational research in neurology and neuroscience 2011: movement disorders. Archives of Neurology. 68: 709-16. PMID 21320985 DOI: 10.1001/Archneurol.2011.11 |
0.358 |
|
| 2010 |
Kegel KB, Sapp E, Alexander J, Reeves P, Bleckmann D, Sobin L, Masso N, Valencia A, Jeong H, Krainc D, Palacino J, Curtis D, Kuhn R, Betschart C, Sena-Esteves M, et al. Huntingtin cleavage product A forms in neurons and is reduced by gamma-secretase inhibitors. Molecular Neurodegeneration. 5: 58. PMID 21156064 DOI: 10.1186/1750-1326-5-58 |
0.372 |
|
| 2010 |
Filimonenko M, Isakson P, Finley KD, Anderson M, Jeong H, Melia TJ, Bartlett BJ, Myers KM, Birkeland HC, Lamark T, Krainc D, Brech A, Stenmark H, Simonsen A, Yamamoto A. The selective macroautophagic degradation of aggregated proteins requires the PI3P-binding protein Alfy. Molecular Cell. 38: 265-79. PMID 20417604 DOI: 10.1016/J.Molcel.2010.04.007 |
0.312 |
|
| 2010 |
Krainc D. Clearance of mutant proteins as a therapeutic target in neurodegenerative diseases. Archives of Neurology. 67: 388-92. PMID 20385902 DOI: 10.1001/Archneurol.2010.40 |
0.418 |
|
| 2010 |
Krainc D. Huntington's disease: tagged for clearance. Nature Medicine. 16: 32-3. PMID 20057421 DOI: 10.1038/Nm0110-32 |
0.436 |
|
| 2009 |
Lovrecic L, Kastrin A, Kobal J, Pirtosek Z, Krainc D, Peterlin B. Gene expression changes in blood as a putative biomarker for Huntington's disease. Movement Disorders : Official Journal of the Movement Disorder Society. 24: 2277-81. PMID 19844910 DOI: 10.1002/Mds.22477 |
0.351 |
|
| 2009 |
Jeong H, Then F, Melia TJ, Mazzulli JR, Cui L, Savas JN, Voisine C, Paganetti P, Tanese N, Hart AC, Yamamoto A, Krainc D. Acetylation targets mutant huntingtin to autophagosomes for degradation. Cell. 137: 60-72. PMID 19345187 DOI: 10.1016/J.Cell.2009.03.018 |
0.415 |
|
| 2008 |
Savas JN, Makusky A, Ottosen S, Baillat D, Then F, Krainc D, Shiekhattar R, Markey SP, Tanese N. Huntington's disease protein contributes to RNA-mediated gene silencing through association with Argonaute and P bodies. Proceedings of the National Academy of Sciences of the United States of America. 105: 10820-5. PMID 18669659 DOI: 10.1073/Pnas.0800658105 |
0.39 |
|
| 2006 |
Weydt P, Pineda VV, Torrence AE, Libby RT, Satterfield TF, Lazarowski ER, Gilbert ML, Morton GJ, Bammler TK, Strand AD, Cui L, Beyer RP, Easley CN, Smith AC, Krainc D, et al. Thermoregulatory and metabolic defects in Huntington's disease transgenic mice implicate PGC-1alpha in Huntington's disease neurodegeneration. Cell Metabolism. 4: 349-62. PMID 17055784 DOI: 10.1016/J.Cmet.2006.10.004 |
0.362 |
|
| 2006 |
Cui L, Jeong H, Borovecki F, Parkhurst CN, Tanese N, Krainc D. Transcriptional repression of PGC-1alpha by mutant huntingtin leads to mitochondrial dysfunction and neurodegeneration. Cell. 127: 59-69. PMID 17018277 DOI: 10.1016/J.Cell.2006.09.015 |
0.372 |
|
| 2006 |
Chen-Plotkin AS, Sadri-Vakili G, Yohrling GJ, Braveman MW, Benn CL, Glajch KE, DiRocco DP, Farrell LA, Krainc D, Gines S, MacDonald ME, Cha JH. Decreased association of the transcription factor Sp1 with genes downregulated in Huntington's disease. Neurobiology of Disease. 22: 233-41. PMID 16442295 DOI: 10.1016/J.Nbd.2005.11.001 |
0.341 |
|
| 2005 |
Zhai W, Jeong H, Cui L, Krainc D, Tjian R. In vitro analysis of huntingtin-mediated transcriptional repression reveals multiple transcription factor targets. Cell. 123: 1241-53. PMID 16377565 DOI: 10.1016/J.Cell.2005.10.030 |
0.392 |
|
| 2005 |
Borovecki F, Lovrecic L, Zhou J, Jeong H, Then F, Rosas HD, Hersch SM, Hogarth P, Bouzou B, Jensen RV, Krainc D. Genome-wide expression profiling of human blood reveals biomarkers for Huntington's disease Proceedings of the National Academy of Sciences of the United States of America. 102: 11023-11028. PMID 16043692 DOI: 10.1073/Pnas.0504921102 |
0.346 |
|
| 2002 |
Luthi-Carter R, Hanson SA, Strand AD, Bergstrom DA, Chun W, Peters NL, Woods AM, Chan EY, Kooperberg C, Krainc D, Young AB, Tapscott SJ, Olson JM. Dysregulation of gene expression in the R6/2 model of polyglutamine disease: parallel changes in muscle and brain. Human Molecular Genetics. 11: 1911-26. PMID 12165554 DOI: 10.1093/Hmg/11.17.1911 |
0.328 |
|
| 2002 |
Dunah AW, Jeong H, Griffin A, Kim YM, Standaert DG, Hersch SM, Mouradian MM, Young AB, Tanese N, Krainc D. Sp1 and TAFII130 transcriptional activity disrupted in early Huntington's disease. Science (New York, N.Y.). 296: 2238-43. PMID 11988536 DOI: 10.1126/Science.1072613 |
0.593 |
|
| 2000 |
Okamoto S, Krainc D, Sherman K, Lipton SA. Antiapoptotic role of the p38 mitogen-activated protein kinase-myocyte enhancer factor 2 transcription factor pathway during neuronal differentiation. Proceedings of the National Academy of Sciences of the United States of America. 97: 7561-6. PMID 10852968 DOI: 10.1073/Pnas.130502697 |
0.347 |
|
| 1995 |
Bonfoco E, Krainc D, Ankarcrona M, Nicotera P, Lipton SA. Apoptosis and necrosis: two distinct events induced, respectively, by mild and intense insults with N-methyl-D-aspartate or nitric oxide/superoxide in cortical cell cultures. Proceedings of the National Academy of Sciences of the United States of America. 92: 7162-6. PMID 7638161 DOI: 10.1073/Pnas.92.16.7162 |
0.317 |
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