Yusuf A. Hannun - Publications

Duke University, Durham, NC 
Cell Biology, Microbiology

220 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2019 Sakamoto W, Canals D, Salamone S, Allopenna J, Clarke CJ, Snider J, Obeid LM, Hannun YA. Probing compartment-specific sphingolipids with targeted bacterial sphingomyelinases and ceramidases. Journal of Lipid Research. PMID 31243119 DOI: 10.1194/jlr.M094722  0.64
2019 Schwartz NU, Mileva I, Gurevich M, Snider J, Hannun YA, Obeid LM. Quantifying 1-deoxydihydroceramides and 1-deoxyceramides in mouse nervous system tissue. Prostaglandins & Other Lipid Mediators. PMID 30790665 DOI: 10.1016/j.prostaglandins.2019.02.005  0.64
2018 Snider JM, Trayssac M, Clarke CJ, Schwartz N, Snider AJ, Obeid LM, Luberto C, Hannun YA. Flux analysis reveals regulation of the sphingolipid network by doxorubicin in breast cancer cells. Journal of Lipid Research. PMID 30573560 DOI: 10.1194/jlr.M089714  0.64
2018 Sakamoto W, Coant N, Canals D, Obeid LM, Hannun YA. Functions of neutral ceramidase in the Golgi apparatus. Journal of Lipid Research. PMID 30154232 DOI: 10.1194/jlr.M088187  0.64
2018 Ren J, Saied EM, Zhong A, Snider J, Ruiz C, Arenz C, Obeid LM, Girnun GD, Hannun YA. Tsc3 regulates SPT amino acid choice in Saccharomyces cerevisiae by promoting alanine in sphingolipid pathway. Journal of Lipid Research. PMID 30154231 DOI: 10.1194/jlr.M088195  0.64
2018 Hannun YA, Obeid LM. Author Correction: Sphingolipids and their metabolism in physiology and disease. Nature Reviews. Molecular Cell Biology. PMID 30111875 DOI: 10.1038/s41580-018-0046-6  0.64
2018 Trayssac M, Hannun YA, Obeid LM. Role of sphingolipids in senescence: implication in aging and age-related diseases. The Journal of Clinical Investigation. 128: 2702-2712. PMID 30108193 DOI: 10.1172/JCI97949  0.64
2018 Newcomb B, Rhein C, Mileva I, Ahmad R, Clarke CJ, Snider J, Obeid LM, Hannun YA. Identification of an acid sphingomyelinase ceramide kinase pathway in the regulation of the chemokine CCL5. Journal of Lipid Research. PMID 29724781 DOI: 10.1194/jlr.M084202  0.64
2018 Coant N, García-Barros M, Zhang Q, Obeid LM, Hannun YA. AKT as a key target for growth promoting functions of neutral ceramidase in colon cancer cells. Oncogene. PMID 29662189 DOI: 10.1038/s41388-018-0236-x  0.64
2018 Snider JM, Snider AJ, Obeid LM, Luberto C, Hannun YA. Probing de novo sphingolipid metabolism in mammalian cells utilizing mass spectrometry. Journal of Lipid Research. PMID 29610123 DOI: 10.1194/jlr.D081646  0.64
2018 Li F, Xu R, Low BE, Lin CL, Garcia-Barros M, Schrandt J, Mileva I, Snider A, Luo CK, Jiang XC, Li MS, Hannun YA, Obeid LM, Wiles MV, Mao C. Alkaline ceramidase 2 is essential for the homeostasis of plasma sphingoid bases and their phosphates. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. fj201700445RR. PMID 29401619 DOI: 10.1096/fj.201700445RR  0.64
2018 Wang K, Xu R, Schrandt J, Shah P, Gong YZ, Preston C, Wang L, Yi JK, Lin CL, Sun W, Spyropoulos DD, Rhee S, Li M, Zhou J, Ge S, ... ... Hannun YA, et al. Correction: Alkaline Ceramidase 3 Deficiency Results in Purkinje Cell Degeneration and Cerebellar Ataxia Due to Dyshomeostasis of Sphingolipids in the Brain. Plos Genetics. 14: e1007190. PMID 29360825 DOI: 10.1371/journal.pgen.1007190  0.64
2018 Pulkoski-Gross MJ, Jenkins ML, Truman JP, Salama MF, Clarke CJ, Burke JE, Hannun YA, Obeid LM. An intrinsic lipid-binding interface controls sphingosine kinase 1 function. Journal of Lipid Research. PMID 29326159 DOI: 10.1194/jlr.M081307  0.64
2018 Carroll BL, Bonica J, Shamseddine AA, Hannun YA, Obeid LM. A role for caspase-2 in sphingosine kinase 1 proteolysis in response to doxorubicin in breast cancer cells - implications for the CHK1-suppressed pathway. Febs Open Bio. 8: 27-40. PMID 29321954 DOI: 10.1002/2211-5463.12344  0.64
2017 Espaillat MP, Snider AJ, Qiu Z, Channer B, Coant N, Schuchman EH, Kew RR, Sheridan BS, Hannun YA, Obeid LM. Loss of acid ceramidase in myeloid cells suppresses intestinal neutrophil recruitment. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. PMID 29259036 DOI: 10.1096/fj.201700585R  0.64
2017 Xu R, Garcia-Barros M, Wen S, Li F, Lin CL, Hannun YA, Obeid LM, Mao C. Tumor suppressor p53 links ceramide metabolism to DNA damage response through alkaline ceramidase 2. Cell Death and Differentiation. PMID 29229990 DOI: 10.1038/s41418-017-0018-y  0.64
2017 Hannun YA, Obeid LM. Sphingolipids and their metabolism in physiology and disease. Nature Reviews. Molecular Cell Biology. PMID 29165427 DOI: 10.1038/nrm.2017.107  0.64
2017 Schwartz NU, Linzer RW, Truman JP, Gurevich M, Hannun YA, Senkal CE, Obeid LM. Decreased ceramide underlies mitochondrial dysfunction in Charcot-Marie-Tooth 2F. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. PMID 29133339 DOI: 10.1096/fj.201701067R  0.64
2017 Ren J, Snider J, Airola MV, Zhong A, Rana NA, Obeid LM, Hannun YA. Quantification of 3-ketodihydrosphingosine using HPLC-ESI-MS/MS to study SPT activity in yeast Saccharomyces cerevisiae. Journal of Lipid Research. PMID 29092960 DOI: 10.1194/jlr.D078535  0.64
2017 Lin CL, Xu R, Yi JK, Li F, Chen J, Jones EC, Slutsky JB, Huang L, Rigas B, Cao J, Zhong X, Snider AJ, Obeid LM, Hannun YA, Mao C. Alkaline Ceramidase 1 Protects Mice from Premature Hair Loss by Maintaining the Homeostasis of Hair Follicle Stem Cells. Stem Cell Reports. PMID 29056331 DOI: 10.1016/j.stemcr.2017.09.015  0.64
2017 Furuya H, Tamashiro PM, Shimizu Y, Iino K, Peres R, Chen R, Sun Y, Hannun YA, Obeid LM, Kawamori T. Sphingosine Kinase 1 expression in Peritoneal Macrophages is required for Colon Carcinogenesis. Carcinogenesis. PMID 29028945 DOI: 10.1093/carcin/bgx104  0.64
2017 Liu M, Clarke CJ, Salama MF, Choi YJ, Obeid LM, Hannun YA. Co-ordinated activation of classical and novel PKC isoforms is required for PMA-induced mTORC1 activation. Plos One. 12: e0184818. PMID 28926616 DOI: 10.1371/journal.pone.0184818  0.64
2017 Airola MV, Shanbhogue P, Shamseddine AA, Guja KE, Senkal CE, Maini R, Bartke N, Wu BX, Obeid LM, Garcia-Diaz M, Hannun YA. Structure of human nSMase2 reveals an interdomain allosteric activation mechanism for ceramide generation. Proceedings of the National Academy of Sciences of the United States of America. PMID 28652336 DOI: 10.1073/pnas.1705134114  0.64
2017 Dupre TV, Doll MA, Shah PP, Sharp CN, Siow D, Megyesi J, Shayman J, Bielwska A, Bielawski J, Beverly LJ, Hernandez-Corbacho M, Clarke CJ, Snider AJ, Schnellmann RG, Obeid LM, ... Hannun YA, et al. Inhibiting glucosylceramide synthase exacerbates cisplatin-induced acute kidney injury. Journal of Lipid Research. PMID 28490444 DOI: 10.1194/jlr.M076745  0.64
2017 Pulkoski-Gross MJ, Uys JD, Orr-Gandy KA, Coant N, Bialkowska AB, Szulc ZM, Bai A, Bielawska A, Townsend DM, Hannun YA, Obeid LM, Snider AJ. Novel sphingosine kinase-1 inhibitor, LCL351, reduces immune responses in murine DSS-induced colitis. Prostaglandins & Other Lipid Mediators. PMID 28377281 DOI: 10.1016/j.prostaglandins.2017.03.006  0.64
2017 Senkal CE, Salama MF, Snider AJ, Allopenna JJ, Rana NA, Koller A, Hannun YA, Obeid LM. Ceramide Is Metabolized to Acylceramide and Stored in Lipid Droplets. Cell Metabolism. 25: 686-697. PMID 28273483 DOI: 10.1016/j.cmet.2017.02.010  0.64
2016 Lu S, Cai C, Yan G, Zhou Z, Wan Y, Chen V, Chen L, Cooper GF, Obeid LM, Hannun YA, Lee AV, Lu X. Signal-oriented pathway analyses reveal a signaling complex as a synthetic lethal target for p53 mutations. Cancer Research. PMID 27758891 DOI: 10.1158/0008-5472.CAN-16-1740  0.64
2016 García-Barros M, Coant N, Kawamori T, Wada M, Snider AJ, Truman JP, Wu BX, Furuya H, Clarke CJ, Bialkowska AB, Ghaleb A, Yang VW, Obeid LM, Hannun YA. Role of neutral ceramidase in colon cancer. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. PMID 27609772 DOI: 10.1096/fj.201600611R  0.64
2016 Snider AJ, Bialkowska AB, Ghaleb AM, Yang VW, Obeid LM, Hannun YA. Murine Model for Colitis-Associated Cancer of the Colon. Methods in Molecular Biology (Clifton, N.J.). 1438: 245-54. PMID 27150094 DOI: 10.1007/978-1-4939-3661-8_14  0.64
2016 Yi JK, Xu R, Jeong E, Mileva I, Truman JP, Lin CL, Wang K, Snider J, Wen S, Obeid LM, Hannun YA, Mao C. Aging-related elevation of sphingoid bases shortens yeast chronological life span by compromising mitochondrial function. Oncotarget. PMID 27008706 DOI: 10.18632/oncotarget.8195  0.64
2016 Xu R, Wang K, Mileva I, Hannun YA, Obeid LM, Mao C. Alkaline ceramidase 2 and its bioactive product sphingosine are novel regulators of the DNA damage response. Oncotarget. PMID 26943039 DOI: 10.18632/oncotarget.7825  0.64
2016 Carroll BL, Pulkoski-Gross MJ, Hannun YA, Obeid LM. CHK1 regulates NF-κB signaling upon DNA damage in p53- deficient cells and associated tumor-derived microvesicles. Oncotarget. PMID 26921248 DOI: 10.18632/oncotarget.7566  0.64
2016 Matmati N, Kitagaki H, Hannun YA. New Role for Ceramide in the Pheromone Response. Cell Cycle (Georgetown, Tex.). 0. PMID 26822556 DOI: 10.1080/15384101.2016.1143271  1
2016 Sundaram K, Mather AR, Marimuthu S, Shah PP, Snider AJ, Obeid LM, Hannun YA, Beverly LJ, Siskind LJ. Loss of neutral ceramidase protects cells from nutrient and energy deprivation-induced cell death. The Biochemical Journal. PMID 26747710 DOI: 10.1042/BJ20150586  0.64
2015 Wu S, Powers S, Zhu W, Hannun YA. Substantial contribution of extrinsic risk factors to cancer development. Nature. PMID 26675728 DOI: 10.1038/nature16166  1
2015 Wang K, Xu R, Schrandt J, Shah P, Gong YZ, Preston C, Wang L, Yi JK, Lin CL, Sun W, Spyropoulos DD, Rhee S, Li M, Zhou J, Ge S, ... ... Hannun YA, et al. Alkaline Ceramidase 3 Deficiency Results in Purkinje Cell Degeneration and Cerebellar Ataxia Due to Dyshomeostasis of Sphingolipids in the Brain. Plos Genetics. 11: e1005591. PMID 26474409 DOI: 10.1371/journal.pgen.1005591  0.64
2015 Hernández-Corbacho MJ, Canals D, Adada MM, Liu M, Senkal CE, Yi JK, Mao C, Luberto C, Hannun YA, Obeid LM. Tumor Necrosis Factor alpha (TNFα)-induced Ceramide Generation via Ceramide Synthases Regulates Loss of Focal Adhesion Kinase (FAK) and Programmed Cell Death. The Journal of Biological Chemistry. PMID 26318452 DOI: 10.1074/jbc.M115.658658  0.64
2015 Kitatani K, Wada M, Perry D, Usui T, Sun Y, Obeid LM, Yaegashi N, Grabowski GA, Hannun YA. Activation of p38 Mitogen-Activated Protein Kinase in Gaucher's Disease. Plos One. 10: e0136633. PMID 26312487 DOI: 10.1371/journal.pone.0136633  1
2015 Adada MM, Canals D, Jeong N, Kelkar AD, Hernandez-Corbacho M, Pulkoski-Gross MJ, Donaldson JC, Hannun YA, Obeid LM. Intracellular sphingosine kinase 2-derived sphingosine-1-phosphate mediates epidermal growth factor-induced ezrin-radixin-moesin phosphorylation and cancer cell invasion. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. 29: 4654-69. PMID 26209696 DOI: 10.1096/fj.15-274340  0.64
2015 Airola MV, Allen WJ, Pulkoski-Gross MJ, Obeid LM, Rizzo RC, Hannun YA. Structural Basis for Ceramide Recognition and Hydrolysis by Human Neutral Ceramidase. Structure (London, England : 1993). 23: 1482-91. PMID 26190575 DOI: 10.1016/j.str.2015.06.013  1
2015 Hannun YA, Newcomb B. A new twist to the emerging functions of ceramides in cancer: novel role for platelet acid sphingomyelinase in cancer metastasis. Embo Molecular Medicine. 7: 692-4. PMID 25859016 DOI: 10.15252/emmm.201505161  1
2015 Salama MF, Carroll B, Adada M, Pulkoski-Gross M, Hannun YA, Obeid LM. A novel role of sphingosine kinase-1 in the invasion and angiogenesis of VHL mutant clear cell renal cell carcinoma. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. 29: 2803-13. PMID 25805832 DOI: 10.1096/fj.15-270413  0.64
2015 Rajagopalan V, Canals D, Luberto C, Snider J, Voelkel-Johnson C, Obeid LM, Hannun YA. Critical determinants of mitochondria-associated neutral sphingomyelinase (MA-nSMase) for mitochondrial localization. Biochimica Et Biophysica Acta. 1850: 628-39. PMID 25484313 DOI: 10.1016/j.bbagen.2014.11.019  1
2015 Shamseddine AA, Airola MV, Hannun YA. Roles and regulation of neutral sphingomyelinase-2 in cellular and pathological processes. Advances in Biological Regulation. 57: 24-41. PMID 25465297 DOI: 10.1016/j.jbior.2014.10.002  1
2015 Espaillat MP, Shamseddine AA, Adada MM, Hannun YA, Obeid LM. Ceramide and sphingosine-1-phosphate in cancer, two faces of the sphinx Translational Cancer Research. 4: 484-499. DOI: 10.3978/j.issn.2218-676X.2015.10.01  0.64
2015 Hannun YA. A personal journey with bioactive lipids European Journal of Lipid Science and Technology. 117: 1814-1831. DOI: 10.1002/ejlt.201500135  1
2014 Snider AJ, Ali WH, Sticca JA, Coant N, Ghaleb AM, Kawamori T, Yang VW, Hannun YA, Obeid LM. Distinct roles for hematopoietic and extra-hematopoietic sphingosine kinase-1 in inflammatory bowel disease. Plos One. 9: e113998. PMID 25460165 DOI: 10.1371/journal.pone.0113998  1
2014 Bai A, Szulc ZM, Bielawski J, Pierce JS, Rembiesa B, Terzieva S, Mao C, Xu R, Wu B, Clarke CJ, Newcomb B, Liu X, Norris J, Hannun YA, Bielawska A. Targeting (cellular) lysosomal acid ceramidase by B13: design, synthesis and evaluation of novel DMG-B13 ester prodrugs. Bioorganic & Medicinal Chemistry. 22: 6933-44. PMID 25456083 DOI: 10.1016/j.bmc.2014.10.025  1
2014 Robinson KA, Hegyi K, Hannun YA, Buse MG, Sethi JK. Go-6976 reverses hyperglycemia-induced insulin resistance independently of cPKC inhibition in adipocytes. Plos One. 9: e108963. PMID 25330241 DOI: 10.1371/journal.pone.0108963  1
2014 Airola MV, Tumolo JM, Snider J, Hannun YA. Identification and biochemical characterization of an acid sphingomyelinase-like protein from the bacterial plant pathogen Ralstonia solanacearum that hydrolyzes ATP to AMP but not sphingomyelin to ceramide. Plos One. 9: e105830. PMID 25144372 DOI: 10.1371/journal.pone.0105830  1
2014 Jones EE, Dworski S, Canals D, Casas J, Fabrias G, Schoenling D, Levade T, Denlinger C, Hannun YA, Medin JA, Drake RR. On-tissue localization of ceramides and other sphingolipids by MALDI mass spectrometry imaging. Analytical Chemistry. 86: 8303-11. PMID 25072097 DOI: 10.1021/ac501937d  1
2014 Spincemaille P, Matmati N, Hannun YA, Cammue BP, Thevissen K. Sphingolipids and mitochondrial function in budding yeast. Biochimica Et Biophysica Acta. 1840: 3131-7. PMID 24973565 DOI: 10.1016/j.bbagen.2014.06.015  1
2014 Perry DM, Newcomb B, Adada M, Wu BX, Roddy P, Kitatani K, Siskind L, Obeid LM, Hannun YA. Defining a role for acid sphingomyelinase in the p38/interleukin-6 pathway. The Journal of Biological Chemistry. 289: 22401-12. PMID 24951586 DOI: 10.1074/jbc.M114.589648  1
2014 Korbelik M, Banáth J, Sun J, Canals D, Hannun YA, Separovic D. Ceramide and sphingosine-1-phosphate act as photodynamic therapy-elicited damage-associated molecular patterns: cell surface exposure. International Immunopharmacology. 20: 359-65. PMID 24713544 DOI: 10.1016/j.intimp.2014.03.016  1
2014 Novgorodov SA, Riley CL, Yu J, Borg KT, Hannun YA, Proia RL, Kindy MS, Gudz TI. Essential roles of neutral ceramidase and sphingosine in mitochondrial dysfunction due to traumatic brain injury. The Journal of Biological Chemistry. 289: 13142-54. PMID 24659784 DOI: 10.1074/jbc.M113.530311  1
2014 Wei J, Ferron M, Clarke CJ, Hannun YA, Jiang H, Blaner WS, Karsenty G. Bone-specific insulin resistance disrupts whole-body glucose homeostasis via decreased osteocalcin activation. The Journal of Clinical Investigation. 124: 1-13. PMID 24642469 DOI: 10.1172/JCI72323  1
2014 Spincemaille P, Chandhok G, Newcomb B, Verbeek J, Vriens K, Zibert A, Schmidt H, Hannun YA, van Pelt J, Cassiman D, Cammue BP, Thevissen K. The plant decapeptide OSIP108 prevents copper-induced apoptosis in yeast and human cells. Biochimica Et Biophysica Acta. 1843: 1207-15. PMID 24632503 DOI: 10.1016/j.bbamcr.2014.03.004  1
2014 Truman JP, García-Barros M, Obeid LM, Hannun YA. Evolving concepts in cancer therapy through targeting sphingolipid metabolism. Biochimica Et Biophysica Acta. 1841: 1174-88. PMID 24384461 DOI: 10.1016/j.bbalip.2013.12.013  1
2014 Vilaça R, Silva E, Nadais A, Teixeira V, Matmati N, Gaifem J, Hannun YA, Sá Miranda MC, Costa V. Sphingolipid signalling mediates mitochondrial dysfunctions and reduced chronological lifespan in the yeast model of Niemann-Pick type C1. Molecular Microbiology. 91: 438-51. PMID 24286211 DOI: 10.1111/mmi.12470  1
2014 Montefusco DJ, Matmati N, Hannun YA. The yeast sphingolipid signaling landscape. Chemistry and Physics of Lipids. 177: 26-40. PMID 24220500 DOI: 10.1016/j.chemphyslip.2013.10.006  1
2014 Swinnen E, Wilms T, Idkowiak-Baldys J, Smets B, De Snijder P, Accardo S, Ghillebert R, Thevissen K, Cammue B, De Vos D, Bielawski J, Hannun YA, Winderickx J. The protein kinase Sch9 is a key regulator of sphingolipid metabolism in Saccharomyces cerevisiae. Molecular Biology of the Cell. 25: 196-211. PMID 24196832 DOI: 10.1091/mbc.E13-06-0340  1
2014 El Osta M, Liu M, Adada M, Senkal CE, Idkowiak-Baldys J, Obeid LM, Clarke CJ, Hannun YA. Sustained PKCβII activity confers oncogenic properties in a phospholipase D- and mTOR-dependent manner. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. 28: 495-505. PMID 24121461 DOI: 10.1096/fj.13-230557  1
2014 García-Barros M, Coant N, Truman JP, Snider AJ, Hannun YA. Sphingolipids in colon cancer. Biochimica Et Biophysica Acta. 1841: 773-82. PMID 24060581 DOI: 10.1016/j.bbalip.2013.09.007  1
2014 Adada M, Canals D, Hannun YA, Obeid LM. Sphingolipid regulation of ezrin, radixin, and moesin proteins family: implications for cell dynamics. Biochimica Et Biophysica Acta. 1841: 727-37. PMID 23850862 DOI: 10.1016/j.bbalip.2013.07.002  1
2013 Liu M, Idkowiak-Baldys J, Roddy PL, Baldys A, Raymond J, Clarke CJ, Hannun YA. Sustained activation of protein kinase C induces delayed phosphorylation and regulates the fate of epidermal growth factor receptor. Plos One. 8: e80721. PMID 24244711 DOI: 10.1371/journal.pone.0080721  1
2013 Montefusco DJ, Chen L, Matmati N, Lu S, Newcomb B, Cooper GF, Hannun YA, Lu X. Distinct signaling roles of ceramide species in yeast revealed through systematic perturbation and systems biology analyses. Science Signaling. 6: rs14. PMID 24170935 DOI: 10.1126/scisignal.2004515  1
2013 Adada MM, Orr-Gandy KA, Snider AJ, Canals D, Hannun YA, Obeid LM, Clarke CJ. Sphingosine kinase 1 regulates tumor necrosis factor-mediated RANTES induction through p38 mitogen-activated protein kinase but independently of nuclear factor κB activation. The Journal of Biological Chemistry. 288: 27667-79. PMID 23935096 DOI: 10.1074/jbc.M113.489443  1
2013 Jin J, Zhang X, Lu Z, Perry DM, Li Y, Russo SB, Cowart LA, Hannun YA, Huang Y. Acid sphingomyelinase plays a key role in palmitic acid-amplified inflammatory signaling triggered by lipopolysaccharide at low concentrations in macrophages. American Journal of Physiology. Endocrinology and Metabolism. 305: E853-67. PMID 23921144 DOI: 10.1152/ajpendo.00251.2013  1
2013 Adada M, Canals D, Hannun YA, Obeid LM. Sphingosine-1-phosphate receptor 2. The Febs Journal. 280: 6354-66. PMID 23879641 DOI: 10.1111/febs.12446  1
2013 Jenkins RW, Clarke CJ, Lucas JT, Shabbir M, Wu BX, Simbari F, Mueller J, Hannun YA, Lazarchick J, Shirai K. Evaluation of the role of secretory sphingomyelinase and bioactive sphingolipids as biomarkers in hemophagocytic lymphohistiocytosis. American Journal of Hematology. 88: E265-72. PMID 23828274 DOI: 10.1002/ajh.23535  1
2013 Chen PW, Fonseca LL, Hannun YA, Voit EO. Coordination of rapid sphingolipid responses to heat stress in yeast. Plos Computational Biology. 9: e1003078. PMID 23737740 DOI: 10.1371/journal.pcbi.1003078  1
2013 Kajimura D, Lee HW, Riley KJ, Arteaga-Solis E, Ferron M, Zhou B, Clarke CJ, Hannun YA, DePinho RA, Guo XE, Guo EX, Mann JJ, Karsenty G. Adiponectin regulates bone mass via opposite central and peripheral mechanisms through FoxO1. Cell Metabolism. 17: 901-15. PMID 23684624 DOI: 10.1016/j.cmet.2013.04.009  1
2013 Cinq-Frais C, Coatrieux C, Grazide MH, Hannun YA, Nègre-Salvayre A, Salvayre R, Augé N. A signaling cascade mediated by ceramide, src and PDGFRβ coordinates the activation of the redox-sensitive neutral sphingomyelinase-2 and sphingosine kinase-1. Biochimica Et Biophysica Acta. 1831: 1344-56. PMID 23651497 DOI: 10.1016/j.bbalip.2013.04.014  1
2013 Orr Gandy KA, Adada M, Canals D, Carroll B, Roddy P, Hannun YA, Obeid LM. Epidermal growth factor-induced cellular invasion requires sphingosine-1-phosphate/sphingosine-1-phosphate 2 receptor-mediated ezrin activation. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. 27: 3155-66. PMID 23629860 DOI: 10.1096/fj.13-228460  1
2013 Matmati N, Metelli A, Tripathi K, Yan S, Mohanty BK, Hannun YA. Identification of C18:1-phytoceramide as the candidate lipid mediator for hydroxyurea resistance in yeast. The Journal of Biological Chemistry. 288: 17272-84. PMID 23620586 DOI: 10.1074/jbc.M112.444802  1
2013 Canals D, Hannun YA. Novel chemotherapeutic drugs in sphingolipid cancer research. Handbook of Experimental Pharmacology. 211-38. PMID 23579458 DOI: 10.1007/978-3-7091-1368-4_12  1
2013 Airola MV, Hannun YA. Sphingolipid metabolism and neutral sphingomyelinases. Handbook of Experimental Pharmacology. 57-76. PMID 23579449 DOI: 10.1007/978-3-7091-1368-4_3  1
2013 Furuya H, Wada M, Shimizu Y, Yamada PM, Hannun YA, Obeid LM, Kawamori T. Effect of sphingosine kinase 1 inhibition on blood pressure. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. 27: 656-64. PMID 23109673 DOI: 10.1096/fj.12-219014  1
2013 Gandy KA, Canals D, Adada M, Wada M, Roddy P, Snider AJ, Hannun YA, Obeid LM. Sphingosine 1-phosphate induces filopodia formation through S1PR2 activation of ERM proteins. The Biochemical Journal. 449: 661-72. PMID 23106337 DOI: 10.1042/BJ20120213  1
2012 Rego A, Costa M, Chaves SR, Matmati N, Pereira H, Sousa MJ, Moradas-Ferreira P, Hannun YA, Costa V, Côrte-Real M. Modulation of mitochondrial outer membrane permeabilization and apoptosis by ceramide metabolism. Plos One. 7: e48571. PMID 23226203 DOI: 10.1371/journal.pone.0048571  1
2012 Snider AJ, Wu BX, Jenkins RW, Sticca JA, Kawamori T, Hannun YA, Obeid LM. Loss of neutral ceramidase increases inflammation in a mouse model of inflammatory bowel disease. Prostaglandins & Other Lipid Mediators. 99: 124-30. PMID 22940715 DOI: 10.1016/j.prostaglandins.2012.08.003  1
2012 Gault CR, Eblen ST, Neumann CA, Hannun YA, Obeid LM. Oncogenic K-Ras regulates bioactive sphingolipids in a sphingosine kinase 1-dependent manner. The Journal of Biological Chemistry. 287: 31794-803. PMID 22833671 DOI: 10.1074/jbc.M112.385765  1
2012 Sewell GW, Hannun YA, Han X, Koster G, Bielawski J, Goss V, Smith PJ, Rahman FZ, Vega R, Bloom SL, Walker AP, Postle AD, Segal AW. Lipidomic profiling in Crohn's disease: Abnormalities in phosphatidylinositols, with preservation of ceramide, phosphatidylcholine and phosphatidylserine composition International Journal of Biochemistry and Cell Biology. 44: 1839-1846. PMID 22728312 DOI: 10.1016/j.biocel.2012.06.016  1
2012 Perry DM, Kitatani K, Roddy P, El-Osta M, Hannun YA. Identification and characterization of protein phosphatase 2C activation by ceramide. Journal of Lipid Research. 53: 1513-21. PMID 22615346 DOI: 10.1194/jlr.M025395  1
2012 Salegio EA, Samaranch L, Jenkins RW, Clarke CJ, Lamarre C, Beyer J, Kells AP, Bringas J, Sebastian WS, Richardson RM, Rosenbluth KH, Hannun YA, Bankiewicz KS, Forsayeth J. Safety study of adeno-associated virus serotype 2-mediated human acid sphingomyelinase expression in the nonhuman primate brain. Human Gene Therapy. 23: 891-902. PMID 22574943 DOI: 10.1089/hum.2012.052  1
2012 Meyers-Needham M, Lewis JA, Gencer S, Sentelle RD, Saddoughi SA, Clarke CJ, Hannun YA, Norell H, da Palma TM, Nishimura M, Kraveka JM, Khavandgar Z, Murshed M, Cevik MO, Ogretmen B. Off-target function of the Sonic hedgehog inhibitor cyclopamine in mediating apoptosis via nitric oxide-dependent neutral sphingomyelinase 2/ceramide induction. Molecular Cancer Therapeutics. 11: 1092-102. PMID 22452947 DOI: 10.1158/1535-7163.MCT-11-0705  1
2012 Apraiz A, Idkowiak-Baldys J, Nieto-Rementería N, Boyano MD, Hannun YA, Asumendi A. Dihydroceramide accumulation and reactive oxygen species are distinct and nonessential events in 4-HPR-mediated leukemia cell death. Biochemistry and Cell Biology = Biochimie Et Biologie Cellulaire. 90: 209-23. PMID 22428532 DOI: 10.1139/o2012-001  1
2012 Thevissen K, de Mello Tavares P, Xu D, Blankenship J, Vandenbosch D, Idkowiak-Baldys J, Govaert G, Bink A, Rozental S, de Groot PW, Davis TR, Kumamoto CA, Vargas G, Nimrichter L, Coenye T, ... ... Hannun YA, et al. The plant defensin RsAFP2 induces cell wall stress, septin mislocalization and accumulation of ceramides in Candida albicans. Molecular Microbiology. 84: 166-80. PMID 22384976 DOI: 10.1111/j.1365-2958.2012.08017.x  1
2012 Beckham TH, Lu P, Cheng JC, Zhao D, Turner LS, Zhang X, Hoffman S, Armeson KE, Liu A, Marrison T, Hannun YA, Liu X. Acid ceramidase-mediated production of sphingosine 1-phosphate promotes prostate cancer invasion through upregulation of cathepsin B. International Journal of Cancer. Journal International Du Cancer. 131: 2034-43. PMID 22322590 DOI: 10.1002/ijc.27480  1
2012 Canals D, Roddy P, Hannun YA. Protein phosphatase 1α mediates ceramide-induced ERM protein dephosphorylation: a novel mechanism independent of phosphatidylinositol 4, 5-biphosphate (PIP2) and myosin/ERM phosphatase. The Journal of Biological Chemistry. 287: 10145-55. PMID 22311981 DOI: 10.1074/jbc.M111.306456  1
2012 Montefusco DJ, Newcomb B, Gandy JL, Brice SE, Matmati N, Cowart LA, Hannun YA. Sphingoid bases and the serine catabolic enzyme CHA1 define a novel feedforward/feedback mechanism in the response to serine availability. The Journal of Biological Chemistry. 287: 9280-9. PMID 22277656 DOI: 10.1074/jbc.M111.313445  1
2012 Mullen TD, Hannun YA, Obeid LM. Ceramide synthases at the centre of sphingolipid metabolism and biology. The Biochemical Journal. 441: 789-802. PMID 22248339 DOI: 10.1042/BJ20111626  1
2012 Horres CR, Hannun YA. The roles of neutral sphingomyelinases in neurological pathologies. Neurochemical Research. 37: 1137-49. PMID 22237969 DOI: 10.1007/s11064-011-0692-y  1
2012 Truman JP, Al Gadban MM, Smith KJ, Jenkins RW, Mayroo N, Virella G, Lopes-Virella MF, Bielawska A, Hannun YA, Hammad SM. Differential regulation of acid sphingomyelinase in macrophages stimulated with oxidized low-density lipoprotein (LDL) and oxidized LDL immune complexes: role in phagocytosis and cytokine release. Immunology. 136: 30-45. PMID 22236141 DOI: 10.1111/j.1365-2567.2012.03552.x  1
2012 Heffernan-Stroud LA, Helke KL, Jenkins RW, De Costa AM, Hannun YA, Obeid LM. Defining a role for sphingosine kinase 1 in p53-dependent tumors. Oncogene. 31: 1166-75. PMID 21765468 DOI: 10.1038/onc.2011.302  1
2011 Alvarez-Vasquez F, Riezman H, Hannun YA, Voit EO. Mathematical modeling and validation of the ergosterol pathway in Saccharomyces cerevisiae. Plos One. 6: e28344. PMID 22194828 DOI: 10.1371/journal.pone.0028344  1
2011 Apraiz A, Idkowiak-Baldys JK, Boyano MD, Pérez-Yarza G, Hannun YA, Asumendi A. Evaluation of bioactive sphingolipids in 4-HPR-resistant leukemia cells. Bmc Cancer. 11: 477. PMID 22061047 DOI: 10.1186/1471-2407-11-477  1
2011 Tripathi K, Matmati N, Zheng WJ, Hannun YA, Mohanty BK. Cellular morphogenesis under stress is influenced by the sphingolipid pathway gene ISC1 and DNA integrity checkpoint genes in Saccharomyces cerevisiae. Genetics. 189: 533-47. PMID 21840863 DOI: 10.1534/genetics.111.132092  1
2011 Saddoughi SA, Garrett-Mayer E, Chaudhary U, O'Brien PE, Afrin LB, Day TA, Gillespie MB, Sharma AK, Wilhoit CS, Bostick R, Senkal CE, Hannun YA, Bielawski J, Simon GR, Shirai K, et al. Results of a phase II trial of gemcitabine plus doxorubicin in patients with recurrent head and neck cancers: serum C₁₈-ceramide as a novel biomarker for monitoring response. Clinical Cancer Research : An Official Journal of the American Association For Cancer Research. 17: 6097-105. PMID 21791630 DOI: 10.1158/1078-0432.CCR-11-0930  1
2011 Khavandgar Z, Poirier C, Clarke CJ, Li J, Wang N, McKee MD, Hannun YA, Murshed M. A cell-autonomous requirement for neutral sphingomyelinase 2 in bone mineralization. The Journal of Cell Biology. 194: 277-89. PMID 21788370 DOI: 10.1083/jcb.201102051  1
2011 Barbosa AD, Osório H, Sims KJ, Almeida T, Alves M, Bielawski J, Amorim MA, Moradas-Ferreira P, Hannun YA, Costa V. Role for Sit4p-dependent mitochondrial dysfunction in mediating the shortened chronological lifespan and oxidative stress sensitivity of Isc1p-deficient cells. Molecular Microbiology. 81: 515-27. PMID 21707788 DOI: 10.1111/j.1365-2958.2011.07714.x  1
2011 Hannun YA, Obeid LM. Many ceramides. The Journal of Biological Chemistry. 286: 27855-62. PMID 21693702 DOI: 10.1074/jbc.R111.254359  1
2011 Hernández-Corbacho MJ, Jenkins RW, Clarke CJ, Hannun YA, Obeid LM, Snider AJ, Siskind LJ. Accumulation of long-chain glycosphingolipids during aging is prevented by caloric restriction. Plos One. 6: e20411. PMID 21687659 DOI: 10.1371/journal.pone.0020411  1
2011 Zhao L, Spassieva SD, Jucius TJ, Shultz LD, Shick HE, Macklin WB, Hannun YA, Obeid LM, Ackerman SL. A deficiency of ceramide biosynthesis causes cerebellar purkinje cell neurodegeneration and lipofuscin accumulation. Plos Genetics. 7: e1002063. PMID 21625621 DOI: 10.1371/journal.pgen.1002063  1
2011 Canals D, Perry DM, Jenkins RW, Hannun YA. Drug targeting of sphingolipid metabolism: sphingomyelinases and ceramidases. British Journal of Pharmacology. 163: 694-712. PMID 21615386 DOI: 10.1111/j.1476-5381.2011.01279.x  1
2011 Novgorodov SA, Wu BX, Gudz TI, Bielawski J, Ovchinnikova TV, Hannun YA, Obeid LM. Novel pathway of ceramide production in mitochondria: thioesterase and neutral ceramidase produce ceramide from sphingosine and acyl-CoA. The Journal of Biological Chemistry. 286: 25352-62. PMID 21613224 DOI: 10.1074/jbc.M110.214866  1
2011 Wu BX, Clarke CJ, Matmati N, Montefusco D, Bartke N, Hannun YA. Identification of novel anionic phospholipid binding domains in neutral sphingomyelinase 2 with selective binding preference. The Journal of Biological Chemistry. 286: 22362-71. PMID 21550973 DOI: 10.1074/jbc.M110.156471  1
2011 Rahmaniyan M, Curley RW, Obeid LM, Hannun YA, Kraveka JM. Identification of dihydroceramide desaturase as a direct in vitro target for fenretinide. The Journal of Biological Chemistry. 286: 24754-64. PMID 21543327 DOI: 10.1074/jbc.M111.250779  1
2011 Clarke CJ, Mediwala K, Jenkins RW, Sutton CA, Tholanikunnel BG, Hannun YA. Neutral sphingomyelinase-2 mediates growth arrest by retinoic acid through modulation of ribosomal S6 kinase. The Journal of Biological Chemistry. 286: 21565-76. PMID 21536668 DOI: 10.1074/jbc.M110.193375  1
2011 Sun Y, Ran H, Liou B, Quinn B, Zamzow M, Zhang W, Bielawski J, Kitatani K, Setchell KD, Hannun YA, Grabowski GA. Isofagomine in vivo effects in a neuronopathic Gaucher disease mouse. Plos One. 6: e19037. PMID 21533102 DOI: 10.1371/journal.pone.0019037  1
2011 El-Osta MA, Idkowiak-Baldys J, Hannun YA. Delayed phosphorylation of classical protein kinase C (PKC) substrates requires PKC internalization and formation of the pericentrion in a phospholipase D (PLD)-dependent manner. The Journal of Biological Chemistry. 286: 19340-53. PMID 21478146 DOI: 10.1074/jbc.M110.152330  1
2011 Mullen TD, Jenkins RW, Clarke CJ, Bielawski J, Hannun YA, Obeid LM. Ceramide synthase-dependent ceramide generation and programmed cell death: involvement of salvage pathway in regulating postmitochondrial events. The Journal of Biological Chemistry. 286: 15929-42. PMID 21388949 DOI: 10.1074/jbc.M111.230870  1
2011 Jenkins RW, Clarke CJ, Canals D, Snider AJ, Gault CR, Heffernan-Stroud L, Wu BX, Simbari F, Roddy P, Kitatani K, Obeid LM, Hannun YA. Regulation of CC ligand 5/RANTES by acid sphingomyelinase and acid ceramidase. The Journal of Biological Chemistry. 286: 13292-303. PMID 21335555 DOI: 10.1074/jbc.M110.163378  1
2011 Clarke CJ, Cloessner EA, Roddy PL, Hannun YA. Neutral sphingomyelinase 2 (nSMase2) is the primary neutral sphingomyelinase isoform activated by tumour necrosis factor-α in MCF-7 cells. The Biochemical Journal. 435: 381-90. PMID 21303347 DOI: 10.1042/BJ20101752  1
2011 Thayyullathil F, Chathoth S, Hago A, Patel M, Szulc ZM, Hannun Y, Galadari S. Purification and characterization of a second type of neutral ceramidase from rat brain: A second more hydrophobic form of rat brain ceramidase Biochimica Et Biophysica Acta - Molecular and Cell Biology of Lipids. 1811: 242-252. PMID 21224012 DOI: 10.1016/j.bbalip.2010.12.012  1
2011 Shirai K, Kaneshiro T, Wada M, Furuya H, Bielawski J, Hannun YA, Obeid LM, Ogretmen B, Kawamori T. A role of sphingosine kinase 1 in head and neck carcinogenesis. Cancer Prevention Research (Philadelphia, Pa.). 4: 454-62. PMID 21209394 DOI: 10.1158/1940-6207.CAPR-10-0299  1
2011 Jenkins RW, Idkowiak-Baldys J, Simbari F, Canals D, Roddy P, Riner CD, Clarke CJ, Hannun YA. A novel mechanism of lysosomal acid sphingomyelinase maturation: requirement for carboxyl-terminal proteolytic processing. The Journal of Biological Chemistry. 286: 3777-88. PMID 21098024 DOI: 10.1074/jbc.M110.155234  1
2011 Hou Q, Jin J, Zhou H, Novgorodov SA, Bielawska A, Szulc ZM, Hannun YA, Obeid LM, Hsu YT. Mitochondrially targeted ceramides preferentially promote autophagy, retard cell growth, and induce apoptosis. Journal of Lipid Research. 52: 278-88. PMID 21081756 DOI: 10.1194/jlr.M012161  1
2011 Clarke CJ, Wu BX, Hannun YA. The neutral sphingomyelinase family: identifying biochemical connections. Advances in Enzyme Regulation. 51: 51-8. PMID 21035485 DOI: 10.1016/j.advenzreg.2010.09.016  1
2011 Mullen TD, Spassieva S, Jenkins RW, Kitatani K, Bielawski J, Hannun YA, Obeid LM. Selective knockdown of ceramide synthases reveals complex interregulation of sphingolipid metabolism. Journal of Lipid Research. 52: 68-77. PMID 20940143 DOI: 10.1194/jlr.M009142  1
2011 Mullen TD, Jenkins RW, Obeid LM, Hannun YA. Ceramide and lipid mediators in apoptosis Apoptosis: Physiology and Pathology. 88-105. DOI: 10.1017/CBO9780511976094.009  1
2010 Voit EO, Alvarez-Vasquez F, Hannun YA. Computational analysis of sphingolipid pathway systems. Advances in Experimental Medicine and Biology. 688: 264-75. PMID 20919661 DOI: 10.1007/978-1-4419-6741-1_19  1
2010 Gault CR, Obeid LM, Hannun YA. An overview of sphingolipid metabolism: from synthesis to breakdown. Advances in Experimental Medicine and Biology. 688: 1-23. PMID 20919643 DOI: 10.1007/978-1-4419-6741-1_1  1
2010 Cowart LA, Gandy JL, Tholanikunnel B, Hannun YA. Sphingolipids mediate formation of mRNA processing bodies during the heat-stress response of Saccharomyces cerevisiae Biochemical Journal. 431: 31-38. PMID 20629639 DOI: 10.1042/BJ20100307  1
2010 Wu BX, Clarke CJ, Hannun YA. Mammalian neutral sphingomyelinases: Regulation and roles in cell signaling responses Neuromolecular Medicine. 12: 320-330. PMID 20552297 DOI: 10.1007/s12017-010-8120-z  1
2010 Zeidan YH, Hannun YA. The acid sphingomyelinase/ceramide pathway: Biomedical significance and mechanisms of regulation Current Molecular Medicine. 10: 454-466. PMID 20540705 DOI: 10.2174/156652410791608225  1
2010 Wu BX, Rajagopalan V, Roddy PL, Clarke CJ, Hannun YA. Identification and characterization of murine mitochondria-associated neutral sphingomyelinase (MA-nSMase), the mammalian sphingomyelin phosphodiesterase 5 Journal of Biological Chemistry. 285: 17993-18002. PMID 20378533 DOI: 10.1074/jbc.M110.102988  1
2010 Devillard R, Galvani S, Thiers JC, Guenet JL, Hannun Y, Bielawski J, Nègre-Salvayre A, Salvayre R, Augé N. Stress-induced sphingolipid signaling: role of type-2 neutral sphingomyelinase in murine cell apoptosis and proliferation. Plos One. 5: e9826. PMID 20352118 DOI: 10.1371/journal.pone.0009826  1
2010 Cowart LA, Shotwell M, Worley ML, Richards AJ, Montefusco DJ, Hannun YA, Lu X. Revealing a signaling role of phytosphingosine-1-phosphate in yeast. Molecular Systems Biology. 6: 349. PMID 20160710 DOI: 10.1038/msb.2010.3  1
2010 Idkowiak-Baldys J, Apraiz A, Li L, Rahmaniyan M, Clarke CJ, Kraveka JM, Asumendi A, Hannun YA. Dihydroceramide desaturase activity is modulated by oxidative stress. The Biochemical Journal. 427: 265-74. PMID 20105137 DOI: 10.1042/BJ20091589  1
2010 Philipp S, Puchert M, Adam-Klages S, Tchikov V, Winoto-Morbach S, Mathieu S, Deerberg A, Kolker L, Marchesini N, Kabelitz D, Hannun YA, Schütze S, Adam D. The Polycomb group protein EED couples TNF receptor 1 to neutral sphingomyelinase Proceedings of the National Academy of Sciences of the United States of America. 107: 1112-1117. PMID 20080539 DOI: 10.1073/pnas.0908486107  1
2010 Sun Y, Liou B, Ran H, Skelton MR, Williams MT, Vorhees CV, Kitatani K, Hannun YA, Witte DP, Xu YH, Grabowski GA. Neuronopathic Gaucher disease in the mouse: viable combined selective saposin C deficiency and mutant glucocerebrosidase (V394L) mice with glucosylsphingosine and glucosylceramide accumulation and progressive neurological deficits. Human Molecular Genetics. 19: 1088-97. PMID 20047948 DOI: 10.1093/hmg/ddp580  1
2010 Thevissen K, Yen WL, Carmona-Gutierrez D, Idkowiak-Baldys J, Aerts AM, François IE, Madeo F, Klionsky DJ, Hannun YA, Cammue BP. Skn1 and Ipt1 negatively regulate autophagy in Saccharomyces cerevisiae. Fems Microbiology Letters. 303: 163-8. PMID 20030721 DOI: 10.1111/j.1574-6968.2009.01869.x  1
2010 Pata MO, Hannun YA, Ng CKY. Plant sphingolipids: Decoding the enigma of the Sphinx New Phytologist. 185: 611-630. PMID 20028469 DOI: 10.1111/j.1469-8137.2009.03123.x  1
2010 Sun Y, Ran H, Zamzow M, Kitatani K, Skelton MR, Williams MT, Vorhees CV, Witte DP, Hannun YA, Grabowski GA. Specific saposin C deficiency: CNS impairment and acid beta-glucosidase effects in the mouse. Human Molecular Genetics. 19: 634-47. PMID 20015957 DOI: 10.1093/hmg/ddp531  1
2010 Milhas D, Clarke CJ, Hannun YA. Sphingomyelin metabolism at the plasma membrane: Implications for bioactive sphingolipids Febs Letters. 584: 1887-1894. PMID 19857494 DOI: 10.1016/j.febslet.2009.10.058  1
2010 Senkal CE, Ponnusamy S, Bielawski J, Hannun YA, Ogretmen B. Antiapoptotic roles of ceramide-synthase-6-generated C16-ceramide via selective regulation of the ATF6/CHOP arm of ER-stress-response pathways. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. 24: 296-308. PMID 19723703 DOI: 10.1096/fj.09-135087  1
2009 Liu X, Cheng JC, Turner LS, Elojeimy S, Beckham TH, Bielawska A, Keane TE, Hannun YA, Norris JS. Acid ceramidase upregulation in prostate cancer: role in tumor development and implications for therapy. Expert Opinion On Therapeutic Targets. 13: 1449-58. PMID 19874262 DOI: 10.1517/14728220903357512  1
2009 Gustafsson K, Sander B, Bielawski J, Hannun YA, Flygare J. Potentiation of cannabinoid-induced cytotoxicity in mantle cell lymphoma through modulation of ceramide metabolism Molecular Cancer Research. 7: 1086-1098. PMID 19609004 DOI: 10.1158/1541-7786.MCR-08-0361  1
2009 Jin J, Mullen TD, Hou Q, Bielawski J, Bielawska A, Zhang X, Obeid LM, Hannun YA, Hsu YT. AMPK inhibitor Compound C stimulates ceramide production and promotes Bax redistribution and apoptosis in MCF7 breast carcinoma cells. Journal of Lipid Research. 50: 2389-97. PMID 19528633 DOI: 10.1194/jlr.M900119-JLR200  1
2009 Idkowiak-Baldys J, Baldys A, Raymond JR, Hannun YA. Sustained receptor stimulation leads to sequestration of recycling endosomes in a classical protein kinase C- and phospholipase D-dependent manner. The Journal of Biological Chemistry. 284: 22322-31. PMID 19525236 DOI: 10.1074/jbc.M109.026765  1
2009 Yang G, Badeanlou L, Bielawski J, Roberts AJ, Hannun YA, Samad F. Central role of ceramide biosynthesis in body weight regulation, energy metabolism, and the metabolic syndrome. American Journal of Physiology. Endocrinology and Metabolism. 297: E211-24. PMID 19435851 DOI: 10.1152/ajpendo.91014.2008  1
2009 Jenkins RW, Canals D, Hannun YA. Roles and regulation of secretory and lysosomal acid sphingomyelinase Cellular Signalling. 21: 836-846. PMID 19385042 DOI: 10.1016/j.cellsig.2009.01.026  1
2009 Wu BX, Zeidan YH, Hannun YA. Downregulation of neutral ceramidase by gemcitabine: Implications for cell cycle regulation Biochimica Et Biophysica Acta - Molecular and Cell Biology of Lipids. 1791: 730-739. PMID 19345744 DOI: 10.1016/j.bbalip.2009.03.012  1
2009 Hannun YA. We need to tackle the mismatch between supply and demand Nature. 458: 404. PMID 19325607 DOI: 10.1038/458404a  1
2009 Kitatani K, Sheldon K, Rajagopalan V, Anelli V, Jenkins RW, Sun Y, Grabowski GA, Obeid LM, Hannun YA. Involvement of acid beta-glucosidase 1 in the salvage pathway of ceramide formation. The Journal of Biological Chemistry. 284: 12972-8. PMID 19279011 DOI: 10.1074/jbc.M802790200  1
2009 Kitatani K, Sheldon K, Anelli V, Jenkins RW, Sun Y, Grabowski GA, Obeid LM, Hannun YA. Acid beta-glucosidase 1 counteracts p38delta-dependent induction of interleukin-6: possible role for ceramide as an anti-inflammatory lipid. The Journal of Biological Chemistry. 284: 12979-88. PMID 19279008 DOI: 10.1074/jbc.M809500200  1
2009 Bai A, Szulc ZM, Bielawski J, Mayroo N, Liu X, Norris J, Hannun YA, Bielawska A. Synthesis and bioevaluation of ω-N-amino analogs of B13 Bioorganic and Medicinal Chemistry. 17: 1840-1848. PMID 19217788 DOI: 10.1016/j.bmc.2009.01.057  1
2009 Kitagaki H, Cowart LA, Matmati N, Montefusco D, Gandy J, de Avalos SV, Novgorodov SA, Zheng J, Obeid LM, Hannun YA. ISC1-dependent metabolic adaptation reveals an indispensable role for mitochondria in induction of nuclear genes during the diauxic shift in Saccharomyces cerevisiae. The Journal of Biological Chemistry. 284: 10818-30. PMID 19179331 DOI: 10.1074/jbc.M805029200  1
2009 Yu H, Zeidan YH, Wu BX, Jenkins RW, Flotte TR, Hannun YA, Virella-Lowell I. Defective acid sphingomyelinase pathway with Pseudomonas aeruginosa infection in cystic fibrosis. American Journal of Respiratory Cell and Molecular Biology. 41: 367-75. PMID 19168701 DOI: 10.1165/rcmb.2008-0295OC  1
2009 Matmati N, Kitagaki H, Montefusco D, Mohanty BK, Hannun YA. Hydroxyurea sensitivity reveals a role for ISC1 in the regulation of G2/M Journal of Biological Chemistry. 284: 8241-8246. PMID 19158081 DOI: 10.1074/jbc.M900004200  1
2009 Mahdy AE, Cheng JC, Li J, Elojeimy S, Meacham WD, Turner LS, Bai A, Gault CR, McPherson AS, Garcia N, Beckham TH, Saad A, Bielawska A, Bielawski J, Hannun YA, et al. Acid ceramidase upregulation in prostate cancer cells confers resistance to radiation: AC inhibition, a potential radiosensitizer. Molecular Therapy : the Journal of the American Society of Gene Therapy. 17: 430-8. PMID 19107118 DOI: 10.1038/mt.2008.281  1
2009 Villa NY, Kupchak BR, Garitaonandia I, Smith JL, Alonso E, Alford C, Cowart LA, Hannun YA, Lyons TJ. Sphingolipids function as downstream effectors of a fungal PAQR. Molecular Pharmacology. 75: 866-75. PMID 19066337 DOI: 10.1124/mol.108.049809  1
2009 Mukhopadhyay A, Saddoughi SA, Song P, Sultan I, Ponnusamy S, Senkal CE, Snook CF, Arnold HK, Sears RC, Hannun YA, Ogretmen B. Direct interaction between the inhibitor 2 and ceramide via sphingolipid-protein binding is involved in the regulation of protein phosphatase 2A activity and signaling. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. 23: 751-63. PMID 19028839 DOI: 10.1096/fj.08-120550  1
2009 Bartke N, Hannun YA. Bioactive sphingolipids: Metabolism and function Journal of Lipid Research. 50: S91-S96. PMID 19017611 DOI: 10.1194/jlr.R800080-JLR200  1
2009 Kawamori T, Kaneshiro T, Okumura M, Maalouf S, Uflacker A, Bielawski J, Hannun YA, Obeid LM. Role for sphingosine kinase 1 in colon carcinogenesis. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. 23: 405-14. PMID 18824518 DOI: 10.1096/fj.08-117572  1
2009 Snider AJ, Kawamori T, Bradshaw SG, Orr KA, Gilkeson GS, Hannun YA, Obeid LM. A role for sphingosine kinase 1 in dextran sulfate sodium-induced colitis. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. 23: 143-52. PMID 18815359 DOI: 10.1096/fj.08-118109  1
2009 Nahas Z, Jiang Y, Zeidan YH, Bielawska A, Szulc Z, Devane L, Kalivas P, Hannun YA. Anti-ceramidase LCL385 acutely reduces BCL-2 expression in the hippocampus but is not associated with an increase of learned helplessness in rats. Behavioural Brain Research. 197: 41-4. PMID 18768150 DOI: 10.1016/j.bbr.2008.07.040  1
2008 Alvarez-Vasquez F, Hannun YA, Voit EO. Dynamics of Positional Enrichment: Theoretical Development and Application to Carbon Labeling in Zymomonas mobilis. Biochemical Engineering Journal. 40: 157-174. PMID 19412323 DOI: 10.1016/j.bej.2007.12.003  1
2008 Montes LR, López DJ, Sot J, Bagatolli LA, Stonehouse MJ, Vasil ML, Wu BX, Hannun YA, Goñi FM, Alonso A. Ceramide-enriched membrane domains in red blood cells and the mechanism of sphingomyelinase-induced hot-cold hemolysis. Biochemistry. 47: 11222-30. PMID 18826261 DOI: 10.1021/bi801139z  1
2008 Zeidan YH, Jenkins RW, Korman JB, Liu X, Obeid LM, Norris JS, Hannun YA. Molecular targeting of acid ceramidase: implications to cancer therapy. Current Drug Targets. 9: 653-61. PMID 18691012 DOI: 10.2174/138945008785132358  1
2008 Chudakova DA, Zeidan YH, Wheeler BW, Yu J, Novgorodov SA, Kindy MS, Hannun YA, Gudz TI. Integrin-associated Lyn kinase promotes cell survival by suppressing acid sphingomyelinase activity. The Journal of Biological Chemistry. 283: 28806-16. PMID 18682390 DOI: 10.1074/jbc.M803301200  1
2008 Jin J, Hou Q, Mullen TD, Zeidan YH, Bielawski J, Kraveka JM, Bielawska A, Obeid LM, Hannun YA, Hsu YT. Ceramide generated by sphingomyelin hydrolysis and the salvage pathway is involved in hypoxia/reoxygenation-induced Bax redistribution to mitochondria in NT-2 cells. The Journal of Biological Chemistry. 283: 26509-17. PMID 18676372 DOI: 10.1074/jbc.M801597200  1
2008 Clarke CJ, Guthrie JM, Hannun YA. Regulation of neutral sphingomyelinase-2 (nSMase2) by tumor necrosis factor-α involves protein kinase C-δ in lung epithelial cells Molecular Pharmacology. 74: 1022-1032. PMID 18653803 DOI: 10.1124/mol.108.046250  1
2008 Pata MO, Wu BX, Bielawski J, Xiong TC, Hannun YA, Ng CKY. Molecular cloning and characterization of OsCDase, a ceramidase enzyme from rice Plant Journal. 55: 1000-1009. PMID 18547394 DOI: 10.1111/j.1365-313X.2008.03569.x  1
2008 Zeidan YH, Jenkins RW, Hannun YA. Remodeling of cellular cytoskeleton by the acid sphingomyelinase/ceramide pathway Journal of Cell Biology. 181: 335-350. PMID 18426979 DOI: 10.1083/jcb.200705060  1
2008 Hannun YA. NIH: Grants revamp needs grounding in evidence Nature. 452: 811. PMID 18421328 DOI: 10.1038/452811c  1
2008 Panjarian S, Kozhaya L, Arayssi S, Yehia M, Bielawski J, Bielawska A, Usta J, Hannun YA, Obeid LM, Dbaibo GS. De novo N-palmitoylsphingosine synthesis is the major biochemical mechanism of ceramide accumulation following p53 up-regulation. Prostaglandins & Other Lipid Mediators. 86: 41-8. PMID 18400537 DOI: 10.1016/j.prostaglandins.2008.02.004  1
2008 Shah C, Yang G, Lee I, Bielawski J, Hannun YA, Samad F. Protection from high fat diet-induced increase in ceramide in mice lacking plasminogen activator inhibitor 1 Journal of Biological Chemistry. 283: 13538-13548. PMID 18359942 DOI: 10.1074/jbc.M709950200  1
2008 Misra S, Obeid LM, Hannun YA, Minamisawa S, Berger FG, Markwald RR, Toole BP, Ghatak S. Hyaluronan constitutively regulates activation of COX-2-mediated cell survival activity in intestinal epithelial and colon carcinoma cells Journal of Biological Chemistry. 283: 14335-14344. PMID 18326857 DOI: 10.1074/jbc.M703811200  1
2008 Matmati N, Hannun YA. ISC1 (inositol phosphosphingolipid-phospholipase C), the yeast homologue of neutral sphingomyelinases Journal of Lipid Research. 49: 922-928. PMID 18305313 DOI: 10.1194/jlr.R800004-JLR200  1
2008 Hannun YA, Obeid LM. Principles of bioactive lipid signalling: lessons from sphingolipids. Nature Reviews. Molecular Cell Biology. 9: 139-50. PMID 18216770 DOI: 10.1038/nrm2329  1
2008 Kitatani K, Idkowiak-Baldys J, Hannun YA. The sphingolipid salvage pathway in ceramide metabolism and signaling. Cellular Signalling. 20: 1010-8. PMID 18191382 DOI: 10.1016/j.cellsig.2007.12.006  1
2008 Dahm F, Bielawska A, Nocito A, Georgiev P, Szulc ZM, Bielawski J, Jochum W, Dindo D, Hannun YA, Clavien PA. Mitochondrially targeted ceramide LCL-30 inhibits colorectal cancer in mice British Journal of Cancer. 98: 98-105. PMID 18026195 DOI: 10.1038/sj.bjc.6604099  1
2008 Liu X, Elojeimy S, Turner LS, Mahdy AE, Zeidan YH, Bielawska A, Bielawski J, Dong JY, El-Zawahry AM, Guo GW, Hannun YA, Holman DH, Rubinchik S, Szulc Z, Keane TE, et al. Acid ceramidase inhibition: a novel target for cancer therapy. Frontiers in Bioscience : a Journal and Virtual Library. 13: 2293-8. PMID 17981711 DOI: 10.2741/2843  1
2008 Bielawska A, Bielawski J, Szulc ZM, Mayroo N, Liu X, Bai A, Elojeimy S, Rembiesa B, Pierce J, Norris JS, Hannun YA. Novel analogs of D-e-MAPP and B13. Part 2: signature effects on bioactive sphingolipids. Bioorganic & Medicinal Chemistry. 16: 1032-45. PMID 17881234 DOI: 10.1016/j.bmc.2007.08.032  1
2008 Szulc ZM, Mayroo N, Bai A, Bielawski J, Liu X, Norris JS, Hannun YA, Bielawska A. Novel analogs of D-e-MAPP and B13. Part 1: synthesis and evaluation as potential anticancer agents. Bioorganic & Medicinal Chemistry. 16: 1015-31. PMID 17869115 DOI: 10.1016/j.bmc.2007.08.033  1
2008 Zeidan YH, Wu BX, Jenkins RW, Obeid LM, Hannun YA. A novel role for protein kinase Cdelta-mediated phosphorylation of acid sphingomyelinase in UV light-induced mitochondrial injury. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. 22: 183-93. PMID 17698617 DOI: 10.1096/fj.07-8967com  1
2008 Holman DH, Turner LS, El-Zawahry A, Elojeimy S, Liu X, Bielawski J, Szulc ZM, Norris K, Zeidan YH, Hannun YA, Bielawska A, Norris JS. Lysosomotropic acid ceramidase inhibitor induces apoptosis in prostate cancer cells. Cancer Chemotherapy and Pharmacology. 61: 231-42. PMID 17429631 DOI: 10.1007/s00280-007-0465-0  1
2007 Shi L, Bielawski J, Mu J, Dong H, Teng C, Zhang J, Yang X, Tomishige N, Hanada K, Hannun YA, Zuo J. Involvement of sphingoid bases in mediating reactive oxygen intermediate production and programmed cell death in Arabidopsis Cell Research. 17: 1030-1040. PMID 18059378 DOI: 10.1038/cr.2007.100  1
2007 Marchesini N, Jones JA, Hannun YA. Confluence induced threonine41/serine45 phospho-β-catenin dephosphorylation via ceramide-mediated activation of PP1cγ Biochimica Et Biophysica Acta - Molecular and Cell Biology of Lipids. 1771: 1418-1428. PMID 17996206 DOI: 10.1016/j.bbalip.2007.10.003  1
2007 Alvarez-Vasquez F, Sims KJ, Voit EO, Hannun YA. Coordination of the dynamics of yeast sphingolipid metabolism during the diauxic shift. Theoretical Biology & Medical Modelling. 4: 42. PMID 17974024 DOI: 10.1186/1742-4682-4-42  1
2007 Sims KJ, Alvarez-Vasquez F, Voit EO, Hannun YA. A guide to biochemical systems modeling of sphingolipids for the biochemist. Methods in Enzymology. 432: 319-50. PMID 17954223 DOI: 10.1016/S0076-6879(07)32013-2  1
2007 Saad AF, Meacham WD, Bai A, Anelli V, Elojeimy S, Mahdy AE, Turner LS, Cheng J, Bielawska A, Bielawski J, Keane TE, Obeid LM, Hannun YA, Norris JS, Liu X. The functional effects of acid ceramidase overexpression in prostate cancer progression and resistance to chemotherapy. Cancer Biology & Therapy. 6: 1455-60. PMID 17881906  1
2007 Kitagaki H, Cowart LA, Matmati N, Vaena de Avalos S, Novgorodov SA, Zeidan YH, Bielawski J, Obeid LM, Hannun YA. Isc1 regulates sphingolipid metabolism in yeast mitochondria. Biochimica Et Biophysica Acta. 1768: 2849-61. PMID 17880915 DOI: 10.1016/j.bbamem.2007.07.019  1
2007 D'Angelo G, Polishchuk E, Tullio GD, Santoro M, Campli AD, Godi A, West G, Bielawski J, Chuang CC, Van Der Spoel AC, Platt FM, Hannun YA, Polishchuk R, Mattjus P, De Matteis MA. Glycosphingolipid synthesis requires FAPP2 transfer of glucosylceramide Nature. 449: 62-67. PMID 17687330 DOI: 10.1038/nature06097  1
2007 Karahatay S, Thomas K, Koybasi S, Senkal CE, Elojeimy S, Liu X, Bielawski J, Day TA, Gillespie MB, Sinha D, Norris JS, Hannun YA, Ogretmen B. Clinical relevance of ceramide metabolism in the pathogenesis of human head and neck squamous cell carcinoma (HNSCC): attenuation of C(18)-ceramide in HNSCC tumors correlates with lymphovascular invasion and nodal metastasis. Cancer Letters. 256: 101-11. PMID 17619081 DOI: 10.1016/j.canlet.2007.06.003  1
2007 Zeidan YH, Hannun YA. Translational aspects of sphingolipid metabolism Trends in Molecular Medicine. 13: 327-336. PMID 17588815 DOI: 10.1016/j.molmed.2007.06.002  1
2007 Kitatani K, Idkowiak-Baldys J, Hannun YA. Mechanism of inhibition of sequestration of protein kinase C alpha/betaII by ceramide. Roles of ceramide-activated protein phosphatases and phosphorylation/dephosphorylation of protein kinase C alpha/betaII on threonine 638/641. The Journal of Biological Chemistry. 282: 20647-56. PMID 17504762 DOI: 10.1074/jbc.M609162200  1
2007 Elojeimy S, Liu X, McKillop JC, El-Zawahry AM, Holman DH, Cheng JY, Meacham WD, Mahdy AE, Saad AF, Turner LS, Cheng J, A Day T, Dong JY, Bielawska A, Hannun YA, et al. Role of acid ceramidase in resistance to FasL: therapeutic approaches based on acid ceramidase inhibitors and FasL gene therapy. Molecular Therapy : the Journal of the American Society of Gene Therapy. 15: 1259-63. PMID 17426710 DOI: 10.1038/sj.mt.6300167  1
2007 Tani M, Hannun YA. Analysis of membrane topology of neutral sphingomyelinase 2 Febs Letters. 581: 1323-1328. PMID 17349629 DOI: 10.1016/j.febslet.2007.02.046  1
2007 Cowart LA, Hannun YA. Selective substrate supply in the regulation of yeast de novo sphingolipid synthesis Journal of Biological Chemistry. 282: 12330-12340. PMID 17322298 DOI: 10.1074/jbc.M700685200  1
2007 Senkal CE, Ponnusamy S, Rossi MJ, Bialewski J, Sinha D, Jiang JC, Jazwinski SM, Hannun YA, Ogretmen B. Role of human longevity assurance gene 1 and C18-ceramide in chemotherapy-induced cell death in human head and neck squamous cell carcinomas. Molecular Cancer Therapeutics. 6: 712-22. PMID 17308067 DOI: 10.1158/1535-7163.MCT-06-0558  1
2007 Zeidan YH, Hannun YA. Activation of acid sphingomyelinase by protein kinase Cδ-mediated phosphorylation Journal of Biological Chemistry. 282: 11549-11561. PMID 17303575 DOI: 10.1074/jbc.M609424200  1
2007 Kraveka JM, Li L, Szulc ZM, Bielawski J, Ogretmen B, Hannun YA, Obeid LM, Bielawska A. Involvement of dihydroceramide desaturase in cell cycle progression in human neuroblastoma cells. The Journal of Biological Chemistry. 282: 16718-28. PMID 17283068 DOI: 10.1074/jbc.M700647200  1
2007 Tellier E, Nègre-Salvayre A, Bocquet B, Itohara S, Hannun YA, Salvayre R, Augé N. Role for furin in tumor necrosis factor alpha-induced activation of the matrix metalloproteinase/sphingolipid mitogenic pathway. Molecular and Cellular Biology. 27: 2997-3007. PMID 17283058 DOI: 10.1128/MCB.01485-06  1
2007 Tani M, Hannun YA. Neutral sphingomyelinase 2 is palmitoylated on multiple cysteine residues: Role of palmitoylation in subcellular localization Journal of Biological Chemistry. 282: 10047-10056. PMID 17272284 DOI: 10.1074/jbc.M611249200  1
2007 Alvi F, Idkowiak-Baldys J, Baldys A, Raymond JR, Hannun YA. Regulation of membrane trafficking and endocytosis by protein kinase C: Emerging role of the pericentrion, a novel protein kinase C-dependent subset of recycling endosomes Cellular and Molecular Life Sciences. 64: 263-270. PMID 17180302 DOI: 10.1007/s00018-006-6363-5  1
2007 Martín SF, Sawai H, Villalba JM, Hannun YA. Redox regulation of neutral sphingomyelinase-1 activity in HEK293 cells through a GSH-dependent mechanism. Archives of Biochemistry and Biophysics. 459: 295-300. PMID 17169322 DOI: 10.1016/j.abb.2006.11.007  1
2007 Wu BX, Snook CF, Tani M, Büllesbach EE, Hannun YA. Large-scale purification and characterization of recombinant Pseudomonas ceramidase: Regulation by calcium Journal of Lipid Research. 48: 600-608. PMID 17164222 DOI: 10.1194/jlr.M600423-JLR200  1
2007 Clarke CJ, Truong TG, Hannun YA. Role for neutral sphingomyelinase-2 in tumor necrosis factor α-stimulated expression of vascular cell adhesion molecule-1 (VCAM) and intercellular adhesion molecule-1 (ICAM) in lung epithelial cells: p38 MAPK is an upstream regulator of nSMase2 Journal of Biological Chemistry. 282: 1384-1396. PMID 17085432 DOI: 10.1074/jbc.M609216200  1
2007 Cowart LA, Hannun YA, Obeid LM. Metabolism and function of sphingolipids in saccharomyces cerevisiae: Relevance to cancer research Yeast as a Tool in Cancer Research. 191-210. DOI: 10.1007/978-1-4020-5963-6_8  1
2007 Szulc ZM, Obeid LM, Hannun YA, Bielawska A. Highly efficient and regioselective phosphorylation of sphingolipids by phase-transfer catalysis Polish Journal of Chemistry. 81: 1899-1909.  1
2006 Taha TA, El-Alwani M, Hannun YA, Obeid LM. Sphingosine kinase-1 is cleaved by cathepsin B in vitro: identification of the initial cleavage sites for the protease. Febs Letters. 580: 6047-54. PMID 17064696 DOI: 10.1016/j.febslet.2006.09.070  1
2006 Kitatani K, Idkowiak-Baldys J, Bielawski J, Taha TA, Jenkins RW, Senkal CE, Ogretmen B, Obeid LM, Hannun YA. Protein kinase C-induced activation of a ceramide/protein phosphatase 1 pathway leading to dephosphorylation of p38 MAPK. The Journal of Biological Chemistry. 281: 36793-802. PMID 17030510 DOI: 10.1074/jbc.M608137200  1
2006 Dahm F, Nocito A, Bielawska A, Lang KS, Georgiev P, Asmis LM, Bielawski J, Madon J, Hannun YA, Clavien PA. Distribution and dynamic changes of sphingolipids in blood in response to platelet activation. Journal of Thrombosis and Haemostasis : Jth. 4: 2704-9. PMID 17010150 DOI: 10.1111/j.1538-7836.2006.02241.x  1
2006 Spassieva S, Seo JG, Jiang JC, Bielawski J, Alvarez-Vasquez F, Jazwinski SM, Hannun YA, Obeid LM. Necessary role for the Lag1p motif in (dihydro)ceramide synthase activity. The Journal of Biological Chemistry. 281: 33931-8. PMID 16951403 DOI: 10.1074/jbc.M608092200  1
2006 Clarke CJ, Hannun YA. Neutral sphingomyelinases and nSMase2: Bridging the gaps Biochimica Et Biophysica Acta - Biomembranes. 1758: 1893-1901. PMID 16938269 DOI: 10.1016/j.bbamem.2006.06.025  1
2006 Szulc ZM, Bielawski J, Gracz H, Gustilo M, Mayroo N, Hannun YA, Obeid LM, Bielawska A. Tailoring structure-function and targeting properties of ceramides by site-specific cationization. Bioorganic & Medicinal Chemistry. 14: 7083-104. PMID 16919460 DOI: 10.1016/j.bmc.2006.07.016  1
2006 Liu X, Elojeimy S, El-Zawahry AM, Holman DH, Bielawska A, Bielawski J, Rubinchik S, Guo GW, Dong JY, Keane T, Hannun YA, Tavassoli M, Norris JS. Modulation of ceramide metabolism enhances viral protein apoptin's cytotoxicity in prostate cancer. Molecular Therapy : the Journal of the American Society of Gene Therapy. 14: 637-46. PMID 16887394 DOI: 10.1016/j.ymthe.2006.06.005  1
2006 Zeidan Y, Marchesini N, Hannun YA. Overview of acid and neutral sphingomyelinases in cell signaling Sphingolipid Biology. 167-181. DOI: 10.1007/4-431-34200-1_12  1
2006 Kitatani K, Cowart LA, Hannun YA. Generation of signaling molecules by de novo sphingolipid synthesis Sphingolipid Biology. 153-165. DOI: 10.1007/4-431-34200-1_11  1
2002 Argraves KM, Obeid LM, Hannun YA. Sphingolipids in vascular biology. Advances in Experimental Medicine and Biology. 507: 439-44. PMID 12664623  0.64
2002 Jenkins GM, Cowart LA, Signorelli P, Pettus BJ, Chalfant CE, Hannun YA. Acute activation of de novo sphingolipid biosynthesis upon heat shock causes an accumulation of ceramide and subsequent dephosphorylation of SR proteins. The Journal of Biological Chemistry. 277: 42572-8. PMID 12200446 DOI: 10.1074/jbc.M207346200  1
2001 Hayter HL, Pettus BJ, Ito F, Obeid LM, Hannun YA. TNFalpha-induced glutathione depletion lies downstream of cPLA(2) in L929 cells. Febs Letters. 507: 151-6. PMID 11684089 DOI: 10.1016/S0014-5793(01)02967-2  1
2001 Jenkins GM, Hannun YA. Role for de novo sphingoid base biosynthesis in the heat-induced transient cell cycle arrest of Saccharomyces cerevisiae. The Journal of Biological Chemistry. 276: 8574-81. PMID 11056159 DOI: 10.1074/jbc.M007425200  1
1997 Mao C, Wadleigh M, Jenkins GM, Hannun YA, Obeid LM. Identification and characterization of Saccharomyces cerevisiae dihydrosphingosine-1-phosphate phosphatase. The Journal of Biological Chemistry. 272: 28690-4. PMID 9353337 DOI: 10.1074/jbc.272.45.28690  1
1997 Jayadev S, Hayter HL, Andrieu N, Gamard CJ, Liu B, Balu R, Hayakawa M, Ito F, Hannun YA. Phospholipase A2 is necessary for tumor necrosis factor alpha-induced ceramide generation in L929 cells. The Journal of Biological Chemistry. 272: 17196-203. PMID 9202042 DOI: 10.1074/jbc.272.27.17196  1
1997 Zhang P, Liu B, Jenkins GM, Hannun YA, Obeid LM. Expression of neutral sphingomyelinase identifies a distinct pool of sphingomyelin involved in apoptosis. The Journal of Biological Chemistry. 272: 9609-12. PMID 9092485 DOI: 10.1074/jbc.272.15.9609  1
1995 Dobrowsky RT, Jenkins GM, Hannun YA. Neurotrophins induce sphingomyelin hydrolysis. Modulation by co-expression of p75NTR with Trk receptors. The Journal of Biological Chemistry. 270: 22135-42. PMID 7673191  1
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