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Yusuf A. Hannun, M.D. - Publications

Affiliations: 
1983-1998 Medicine Duke University, Durham, NC 
 1998-2012 Biochemistry Medical University of South Carolina, Charleston, SC, United States 
 2012- Cancer Center Stony Brook University, Stony Brook, NY, United States 
Area:
cancer biology, Lipid biology, lipid singing
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312 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2021 Truman JP, Ruiz CF, Montal E, Garcia-Barros M, Mileva I, Snider AJ, Hannun YA, Obeid LM, Mao C. 1-Deoxysphinganine initiates adaptive responses to serine and glycine starvation in cancer cells via proteolysis of sphingosine kinase. Journal of Lipid Research. 63: 100154. PMID 34838542 DOI: 10.1016/j.jlr.2021.100154  0.309
2021 Truman JP, Ruiz CF, Trayssac M, Mao C, Hannun YA, Obeid LM. Sphingosine kinase 1 downregulation is required for adaptation to serine deprivation. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. 35: e21284. PMID 33484475 DOI: 10.1096/fj.202001814RR  0.313
2021 Zhang X, Sakamoto W, Canals D, Ishibashi M, Matsuda M, Nishida K, Toyoshima M, Shigeta S, Taniguchi M, Senkal CE, Okazaki T, Yaegashi N, Hannun YA, Nabe T, Kitatani K. Ceramide synthase 2-C -ceramide axis limits the metastatic potential of ovarian cancer cells. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. 35: e21287. PMID 33423335 DOI: 10.1096/fj.202001504RR  0.328
2021 Thayyullathil F, Cheratta AR, Alakkal A, Subburayan K, Pallichankandy S, Hannun YA, Galadari S. Acid sphingomyelinase-dependent autophagic degradation of GPX4 is critical for the execution of ferroptosis. Cell Death & Disease. 12: 26. PMID 33414455 DOI: 10.1038/s41419-020-03297-w  0.326
2020 Zhao D, Hajiaghamohseni LM, Liu X, Szulc ZM, Bai A, Bielawska A, Norris JS, Reddy SV, Hannun YA, Haque A. Inhibition of acid ceramidase regulates MHC class II antigen presentation and suppression of autoimmune arthritis. Cytokine. 135: 155219. PMID 32738771 DOI: 10.1016/J.Cyto.2020.155219  0.317
2019 Shanbhogue P, Hoffmann RM, Airola MV, Maini R, Hamelin DJ, Garcia-Diaz M, Burke JE, Hannun YA. The juxtamembrane linker in neutral sphingomyelinase-2 functions as an intramolecular allosteric switch that activates the enzyme. The Journal of Biological Chemistry. PMID 30890560 DOI: 10.1074/Jbc.Ra118.007288  0.335
2018 Sakamoto W, Coant N, Canals D, Obeid LM, Hannun YA. Functions of neutral ceramidase in the Golgi apparatus. Journal of Lipid Research. PMID 30154232 DOI: 10.1194/Jlr.M088187  0.428
2018 Carroll BL, Bonica J, Shamseddine AA, Hannun YA, Obeid LM. A role for caspase-2 in sphingosine kinase 1 proteolysis in response to doxorubicin in breast cancer cells - implications for the CHK1-suppressed pathway. Febs Open Bio. 8: 27-40. PMID 29321954 DOI: 10.1002/2211-5463.12344  0.301
2017 Liu M, Clarke CJ, Salama MF, Choi YJ, Obeid LM, Hannun YA. Co-ordinated activation of classical and novel PKC isoforms is required for PMA-induced mTORC1 activation. Plos One. 12: e0184818. PMID 28926616 DOI: 10.1371/journal.pone.0184818  0.324
2016 García-Barros M, Coant N, Kawamori T, Wada M, Snider AJ, Truman JP, Wu BX, Furuya H, Clarke CJ, Bialkowska AB, Ghaleb A, Yang VW, Obeid LM, Hannun YA. Role of neutral ceramidase in colon cancer. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. PMID 27609772 DOI: 10.1096/Fj.201600611R  0.358
2016 Sundaram K, Mather AR, Marimuthu S, Shah PP, Snider AJ, Obeid LM, Hannun YA, Beverly LJ, Siskind LJ. Loss of neutral ceramidase protects cells from nutrient and energy deprivation-induced cell death. The Biochemical Journal. PMID 26747710 DOI: 10.1042/BJ20150586  0.314
2015 Hernández-Corbacho MJ, Canals D, Adada MM, Liu M, Senkal CE, Yi JK, Mao C, Luberto C, Hannun YA, Obeid LM. Tumor Necrosis Factor alpha (TNFα)-induced Ceramide Generation via Ceramide Synthases Regulates Loss of Focal Adhesion Kinase (FAK) and Programmed Cell Death. The Journal of Biological Chemistry. PMID 26318452 DOI: 10.1074/jbc.M115.658658  0.376
2015 Espaillat MP, Shamseddine AA, Adada MM, Hannun YA, Obeid LM. Ceramide and sphingosine-1-phosphate in cancer, two faces of the sphinx Translational Cancer Research. 4: 484-499. DOI: 10.21037/5424  0.334
2014 Swinnen E, Wilms T, Idkowiak-Baldys J, Smets B, De Snijder P, Accardo S, Ghillebert R, Thevissen K, Cammue B, De Vos D, Bielawski J, Hannun YA, Winderickx J. The protein kinase Sch9 is a key regulator of sphingolipid metabolism in Saccharomyces cerevisiae. Molecular Biology of the Cell. 25: 196-211. PMID 24196832 DOI: 10.1091/Mbc.E13-06-0340  0.424
2014 El Osta M, Liu M, Adada M, Senkal CE, Idkowiak-Baldys J, Obeid LM, Clarke CJ, Hannun YA. Sustained PKCβII activity confers oncogenic properties in a phospholipase D- and mTOR-dependent manner. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. 28: 495-505. PMID 24121461 DOI: 10.1096/Fj.13-230557  0.436
2014 Kajimura D, Lee HW, Riley KJ, Arteaga-Solis E, Ferron M, Zhou B, Clarke CJ, Hannun YA, Depinho RA, Guo XE, Mann JJ, Karsenty G. Erratum: Adiponectin regulates bone mass via opposite central and peripheral mechanisms through FoxO1 (Cell Metabolism (2013) 17 (901-915)) Cell Metabolism. 19. DOI: 10.1016/J.Cmet.2014.04.013  0.303
2013 Orr Gandy KA, Adada M, Canals D, Carroll B, Roddy P, Hannun YA, Obeid LM. Epidermal growth factor-induced cellular invasion requires sphingosine-1-phosphate/sphingosine-1-phosphate 2 receptor-mediated ezrin activation. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. 27: 3155-66. PMID 23629860 DOI: 10.1096/Fj.13-228460  0.427
2013 Matmati N, Metelli A, Tripathi K, Yan S, Mohanty BK, Hannun YA. Identification of C18:1-phytoceramide as the candidate lipid mediator for hydroxyurea resistance in yeast. The Journal of Biological Chemistry. 288: 17272-84. PMID 23620586 DOI: 10.1074/jbc.M112.444802  0.366
2013 Furuya H, Wada M, Shimizu Y, Yamada PM, Hannun YA, Obeid LM, Kawamori T. Effect of sphingosine kinase 1 inhibition on blood pressure. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. 27: 656-64. PMID 23109673 DOI: 10.1096/Fj.12-219014  0.372
2012 Gault CR, Eblen ST, Neumann CA, Hannun YA, Obeid LM. Oncogenic K-Ras regulates bioactive sphingolipids in a sphingosine kinase 1-dependent manner. The Journal of Biological Chemistry. 287: 31794-803. PMID 22833671 DOI: 10.1074/Jbc.M112.385765  0.382
2012 Perry DM, Kitatani K, Roddy P, El-Osta M, Hannun YA. Identification and characterization of protein phosphatase 2C activation by ceramide. Journal of Lipid Research. 53: 1513-21. PMID 22615346 DOI: 10.1194/Jlr.M025395  0.4
2012 Meyers-Needham M, Lewis JA, Gencer S, Sentelle RD, Saddoughi SA, Clarke CJ, Hannun YA, Norell H, da Palma TM, Nishimura M, Kraveka JM, Khavandgar Z, Murshed M, Cevik MO, Ogretmen B. Off-target function of the Sonic hedgehog inhibitor cyclopamine in mediating apoptosis via nitric oxide-dependent neutral sphingomyelinase 2/ceramide induction. Molecular Cancer Therapeutics. 11: 1092-102. PMID 22452947 DOI: 10.1158/1535-7163.Mct-11-0705  0.417
2012 Apraiz A, Idkowiak-Baldys J, Nieto-Rementería N, Boyano MD, Hannun YA, Asumendi A. Dihydroceramide accumulation and reactive oxygen species are distinct and nonessential events in 4-HPR-mediated leukemia cell death. Biochemistry and Cell Biology = Biochimie Et Biologie Cellulaire. 90: 209-23. PMID 22428532 DOI: 10.1139/O2012-001  0.387
2012 Thevissen K, de Mello Tavares P, Xu D, Blankenship J, Vandenbosch D, Idkowiak-Baldys J, Govaert G, Bink A, Rozental S, de Groot PW, Davis TR, Kumamoto CA, Vargas G, Nimrichter L, Coenye T, ... ... Hannun YA, et al. The plant defensin RsAFP2 induces cell wall stress, septin mislocalization and accumulation of ceramides in Candida albicans. Molecular Microbiology. 84: 166-80. PMID 22384976 DOI: 10.1111/J.1365-2958.2012.08017.X  0.404
2012 Canals D, Roddy P, Hannun YA. Protein phosphatase 1α mediates ceramide-induced ERM protein dephosphorylation: a novel mechanism independent of phosphatidylinositol 4, 5-biphosphate (PIP2) and myosin/ERM phosphatase. The Journal of Biological Chemistry. 287: 10145-55. PMID 22311981 DOI: 10.1074/Jbc.M111.306456  0.37
2012 Mullen TD, Hannun YA, Obeid LM. Ceramide synthases at the centre of sphingolipid metabolism and biology. The Biochemical Journal. 441: 789-802. PMID 22248339 DOI: 10.1042/Bj20111626  0.381
2012 Truman JP, Al Gadban MM, Smith KJ, Jenkins RW, Mayroo N, Virella G, Lopes-Virella MF, Bielawska A, Hannun YA, Hammad SM. Differential regulation of acid sphingomyelinase in macrophages stimulated with oxidized low-density lipoprotein (LDL) and oxidized LDL immune complexes: role in phagocytosis and cytokine release. Immunology. 136: 30-45. PMID 22236141 DOI: 10.1111/J.1365-2567.2012.03552.X  0.333
2011 Apraiz A, Idkowiak-Baldys JK, Boyano MD, Pérez-Yarza G, Hannun YA, Asumendi A. Evaluation of bioactive sphingolipids in 4-HPR-resistant leukemia cells. Bmc Cancer. 11: 477. PMID 22061047 DOI: 10.1186/1471-2407-11-477  0.355
2011 Tripathi K, Matmati N, Zheng WJ, Hannun YA, Mohanty BK. Cellular morphogenesis under stress is influenced by the sphingolipid pathway gene ISC1 and DNA integrity checkpoint genes in Saccharomyces cerevisiae. Genetics. 189: 533-47. PMID 21840863 DOI: 10.1534/Genetics.111.132092  0.38
2011 Barbosa AD, Osório H, Sims KJ, Almeida T, Alves M, Bielawski J, Amorim MA, Moradas-Ferreira P, Hannun YA, Costa V. Role for Sit4p-dependent mitochondrial dysfunction in mediating the shortened chronological lifespan and oxidative stress sensitivity of Isc1p-deficient cells. Molecular Microbiology. 81: 515-27. PMID 21707788 DOI: 10.1111/J.1365-2958.2011.07714.X  0.384
2011 Zhao L, Spassieva SD, Jucius TJ, Shultz LD, Shick HE, Macklin WB, Hannun YA, Obeid LM, Ackerman SL. A deficiency of ceramide biosynthesis causes cerebellar purkinje cell neurodegeneration and lipofuscin accumulation. Plos Genetics. 7: e1002063. PMID 21625621 DOI: 10.1371/Journal.Pgen.1002063  0.352
2011 Canals D, Perry DM, Jenkins RW, Hannun YA. Drug targeting of sphingolipid metabolism: sphingomyelinases and ceramidases. British Journal of Pharmacology. 163: 694-712. PMID 21615386 DOI: 10.1111/J.1476-5381.2011.01279.X  0.374
2011 Novgorodov SA, Wu BX, Gudz TI, Bielawski J, Ovchinnikova TV, Hannun YA, Obeid LM. Novel pathway of ceramide production in mitochondria: thioesterase and neutral ceramidase produce ceramide from sphingosine and acyl-CoA. The Journal of Biological Chemistry. 286: 25352-62. PMID 21613224 DOI: 10.1074/Jbc.M110.214866  0.328
2011 Rahmaniyan M, Curley RW, Obeid LM, Hannun YA, Kraveka JM. Identification of dihydroceramide desaturase as a direct in vitro target for fenretinide. The Journal of Biological Chemistry. 286: 24754-64. PMID 21543327 DOI: 10.1074/Jbc.M111.250779  0.351
2011 Sun Y, Ran H, Liou B, Quinn B, Zamzow M, Zhang W, Bielawski J, Kitatani K, Setchell KD, Hannun YA, Grabowski GA. Isofagomine in vivo effects in a neuronopathic Gaucher disease mouse. Plos One. 6: e19037. PMID 21533102 DOI: 10.1371/Journal.Pone.0019037  0.338
2011 Mullen TD, Jenkins RW, Clarke CJ, Bielawski J, Hannun YA, Obeid LM. Ceramide synthase-dependent ceramide generation and programmed cell death: involvement of salvage pathway in regulating postmitochondrial events. The Journal of Biological Chemistry. 286: 15929-42. PMID 21388949 DOI: 10.1074/Jbc.M111.230870  0.44
2011 Clarke CJ, Cloessner EA, Roddy PL, Hannun YA. Neutral sphingomyelinase 2 (nSMase2) is the primary neutral sphingomyelinase isoform activated by tumour necrosis factor-α in MCF-7 cells. The Biochemical Journal. 435: 381-90. PMID 21303347 DOI: 10.1042/Bj20101752  0.371
2011 Shirai K, Kaneshiro T, Wada M, Furuya H, Bielawski J, Hannun YA, Obeid LM, Ogretmen B, Kawamori T. A role of sphingosine kinase 1 in head and neck carcinogenesis. Cancer Prevention Research (Philadelphia, Pa.). 4: 454-62. PMID 21209394 DOI: 10.1158/1940-6207.Capr-10-0299  0.359
2011 Jenkins RW, Idkowiak-Baldys J, Simbari F, Canals D, Roddy P, Riner CD, Clarke CJ, Hannun YA. A novel mechanism of lysosomal acid sphingomyelinase maturation: requirement for carboxyl-terminal proteolytic processing. The Journal of Biological Chemistry. 286: 3777-88. PMID 21098024 DOI: 10.1074/Jbc.M110.155234  0.344
2011 Hou Q, Jin J, Zhou H, Novgorodov SA, Bielawska A, Szulc ZM, Hannun YA, Obeid LM, Hsu YT. Mitochondrially targeted ceramides preferentially promote autophagy, retard cell growth, and induce apoptosis. Journal of Lipid Research. 52: 278-88. PMID 21081756 DOI: 10.1194/Jlr.M012161  0.403
2011 Clarke CJ, Wu BX, Hannun YA. The neutral sphingomyelinase family: identifying biochemical connections. Advances in Enzyme Regulation. 51: 51-8. PMID 21035485 DOI: 10.1016/J.Advenzreg.2010.09.016  0.304
2011 Mullen TD, Spassieva S, Jenkins RW, Kitatani K, Bielawski J, Hannun YA, Obeid LM. Selective knockdown of ceramide synthases reveals complex interregulation of sphingolipid metabolism. Journal of Lipid Research. 52: 68-77. PMID 20940143 DOI: 10.1194/Jlr.M009142  0.376
2011 An D, Na C, Bielawski J, Hannun YA, Kasper DL. Membrane sphingolipids as essential molecular signals for Bacteroides survival in the intestine. Proceedings of the National Academy of Sciences of the United States of America. 108: 4666-71. PMID 20855611 DOI: 10.1073/Pnas.1001501107  0.309
2011 Cheng JC, Beckham TH, Marrison ST, Bai A, Wu BX, Liu A, Marshall DT, Keane TE, Hannun YA, Liu X, Norris JS. Abstract 2497: Induction of AP-1 activity by ceramide results in ASAH1 upregulation: A mechanism of prostate cancer cell radioresistance Cancer Research. 71: 2497-2497. DOI: 10.1158/1538-7445.Am2011-2497  0.417
2010 Gault CR, Obeid LM, Hannun YA. An overview of sphingolipid metabolism: from synthesis to breakdown. Advances in Experimental Medicine and Biology. 688: 1-23. PMID 20919643 DOI: 10.1007/978-1-4419-6741-1_1  0.368
2010 Jenkins RW, Canals D, Idkowiak-Baldys J, Simbari F, Roddy P, Perry DM, Kitatani K, Luberto C, Hannun YA. Regulated secretion of acid sphingomyelinase: implications for selectivity of ceramide formation. The Journal of Biological Chemistry. 285: 35706-18. PMID 20807762 DOI: 10.1074/Jbc.M110.125609  0.401
2010 Milhas D, Clarke CJ, Idkowiak-Baldys J, Canals D, Hannun YA. Anterograde and retrograde transport of neutral sphingomyelinase-2 between the Golgi and the plasma membrane. Biochimica Et Biophysica Acta. 1801: 1361-74. PMID 20713176 DOI: 10.1016/J.Bbalip.2010.08.001  0.394
2010 Wu BX, Clarke CJ, Hannun YA. Mammalian neutral sphingomyelinases: Regulation and roles in cell signaling responses Neuromolecular Medicine. 12: 320-330. PMID 20552297 DOI: 10.1007/S12017-010-8120-Z  0.402
2010 Zeidan YH, Hannun YA. The acid sphingomyelinase/ceramide pathway: Biomedical significance and mechanisms of regulation Current Molecular Medicine. 10: 454-466. PMID 20540705 DOI: 10.2174/156652410791608225  0.395
2010 Uchida Y, Houben E, Park K, Douangpanya S, Lee YM, Wu BX, Hannun YA, Radin NS, Elias PM, Holleran WM. Hydrolytic pathway protects against ceramide-induced apoptosis in keratinocytes exposed to UVB. The Journal of Investigative Dermatology. 130: 2472-80. PMID 20520628 DOI: 10.1038/Jid.2010.153  0.387
2010 Wu BX, Rajagopalan V, Roddy PL, Clarke CJ, Hannun YA. Identification and characterization of murine mitochondria-associated neutral sphingomyelinase (MA-nSMase), the mammalian sphingomyelin phosphodiesterase 5 Journal of Biological Chemistry. 285: 17993-18002. PMID 20378533 DOI: 10.1074/Jbc.M110.102988  0.373
2010 Devillard R, Galvani S, Thiers JC, Guenet JL, Hannun Y, Bielawski J, Nègre-Salvayre A, Salvayre R, Augé N. Stress-induced sphingolipid signaling: role of type-2 neutral sphingomyelinase in murine cell apoptosis and proliferation. Plos One. 5: e9826. PMID 20352118 DOI: 10.1371/Journal.Pone.0009826  0.375
2010 Cowart LA, Shotwell M, Worley ML, Richards AJ, Montefusco DJ, Hannun YA, Lu X. Revealing a signaling role of phytosphingosine-1-phosphate in yeast. Molecular Systems Biology. 6: 349. PMID 20160710 DOI: 10.1038/Msb.2010.3  0.37
2010 Idkowiak-Baldys J, Apraiz A, Li L, Rahmaniyan M, Clarke CJ, Kraveka JM, Asumendi A, Hannun YA. Dihydroceramide desaturase activity is modulated by oxidative stress. The Biochemical Journal. 427: 265-74. PMID 20105137 DOI: 10.1042/Bj20091589  0.307
2010 Philipp S, Puchert M, Adam-Klages S, Tchikov V, Winoto-Morbach S, Mathieu S, Deerberg A, Kolker L, Marchesini N, Kabelitz D, Hannun YA, Schütze S, Adam D. The Polycomb group protein EED couples TNF receptor 1 to neutral sphingomyelinase Proceedings of the National Academy of Sciences of the United States of America. 107: 1112-1117. PMID 20080539 DOI: 10.1073/Pnas.0908486107  0.353
2010 Sun Y, Liou B, Ran H, Skelton MR, Williams MT, Vorhees CV, Kitatani K, Hannun YA, Witte DP, Xu YH, Grabowski GA. Neuronopathic Gaucher disease in the mouse: viable combined selective saposin C deficiency and mutant glucocerebrosidase (V394L) mice with glucosylsphingosine and glucosylceramide accumulation and progressive neurological deficits. Human Molecular Genetics. 19: 1088-97. PMID 20047948 DOI: 10.1093/Hmg/Ddp580  0.336
2010 Thevissen K, Yen WL, Carmona-Gutierrez D, Idkowiak-Baldys J, Aerts AM, François IE, Madeo F, Klionsky DJ, Hannun YA, Cammue BP. Skn1 and Ipt1 negatively regulate autophagy in Saccharomyces cerevisiae. Fems Microbiology Letters. 303: 163-8. PMID 20030721 DOI: 10.1111/J.1574-6968.2009.01869.X  0.311
2010 Sun Y, Ran H, Zamzow M, Kitatani K, Skelton MR, Williams MT, Vorhees CV, Witte DP, Hannun YA, Grabowski GA. Specific saposin C deficiency: CNS impairment and acid beta-glucosidase effects in the mouse. Human Molecular Genetics. 19: 634-47. PMID 20015957 DOI: 10.1093/Hmg/Ddp531  0.351
2010 Milhas D, Clarke CJ, Hannun YA. Sphingomyelin metabolism at the plasma membrane: Implications for bioactive sphingolipids Febs Letters. 584: 1887-1894. PMID 19857494 DOI: 10.1016/J.Febslet.2009.10.058  0.322
2010 Senkal CE, Ponnusamy S, Bielawski J, Hannun YA, Ogretmen B. Antiapoptotic roles of ceramide-synthase-6-generated C16-ceramide via selective regulation of the ATF6/CHOP arm of ER-stress-response pathways. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. 24: 296-308. PMID 19723703 DOI: 10.1096/Fj.09-135087  0.318
2010 Kawamori T, Furuya H, Wada M, Bielawski J, Hannun YA, Obeid LM. Abstract B80: Role for sphingosine kinase 1 in colon carcinogenesis Cancer Prevention Research. 3. DOI: 10.1158/1940-6207.Prev-09-B80  0.329
2010 Shirai K, Furuya H, Wada M, Bielawski J, Ogretmen B, Hannun YA, Obeid LM, Kawamori T. Abstract 5656: Role for Sphingosine kinase 1 in head & neck cancer Cancer Research. 70: 5656-5656. DOI: 10.1158/1538-7445.Am10-5656  0.313
2009 Liu X, Cheng JC, Turner LS, Elojeimy S, Beckham TH, Bielawska A, Keane TE, Hannun YA, Norris JS. Acid ceramidase upregulation in prostate cancer: role in tumor development and implications for therapy. Expert Opinion On Therapeutic Targets. 13: 1449-58. PMID 19874262 DOI: 10.1517/14728220903357512  0.371
2009 Gustafsson K, Sander B, Bielawski J, Hannun YA, Flygare J. Potentiation of cannabinoid-induced cytotoxicity in mantle cell lymphoma through modulation of ceramide metabolism Molecular Cancer Research. 7: 1086-1098. PMID 19609004 DOI: 10.1158/1541-7786.Mcr-08-0361  0.422
2009 Jin J, Mullen TD, Hou Q, Bielawski J, Bielawska A, Zhang X, Obeid LM, Hannun YA, Hsu YT. AMPK inhibitor Compound C stimulates ceramide production and promotes Bax redistribution and apoptosis in MCF7 breast carcinoma cells. Journal of Lipid Research. 50: 2389-97. PMID 19528633 DOI: 10.1194/Jlr.M900119-Jlr200  0.396
2009 Idkowiak-Baldys J, Baldys A, Raymond JR, Hannun YA. Sustained receptor stimulation leads to sequestration of recycling endosomes in a classical protein kinase C- and phospholipase D-dependent manner. The Journal of Biological Chemistry. 284: 22322-31. PMID 19525236 DOI: 10.1074/Jbc.M109.026765  0.339
2009 Jenkins RW, Canals D, Hannun YA. Roles and regulation of secretory and lysosomal acid sphingomyelinase Cellular Signalling. 21: 836-846. PMID 19385042 DOI: 10.1016/J.Cellsig.2009.01.026  0.367
2009 Wu BX, Zeidan YH, Hannun YA. Downregulation of neutral ceramidase by gemcitabine: Implications for cell cycle regulation Biochimica Et Biophysica Acta - Molecular and Cell Biology of Lipids. 1791: 730-739. PMID 19345744 DOI: 10.1016/J.Bbalip.2009.03.012  0.441
2009 Kitatani K, Sheldon K, Rajagopalan V, Anelli V, Jenkins RW, Sun Y, Grabowski GA, Obeid LM, Hannun YA. Involvement of acid beta-glucosidase 1 in the salvage pathway of ceramide formation. The Journal of Biological Chemistry. 284: 12972-8. PMID 19279011 DOI: 10.1074/Jbc.M802790200  0.443
2009 Kitatani K, Sheldon K, Anelli V, Jenkins RW, Sun Y, Grabowski GA, Obeid LM, Hannun YA. Acid beta-glucosidase 1 counteracts p38delta-dependent induction of interleukin-6: possible role for ceramide as an anti-inflammatory lipid. The Journal of Biological Chemistry. 284: 12979-88. PMID 19279008 DOI: 10.1074/Jbc.M809500200  0.366
2009 Bai A, Szulc ZM, Bielawski J, Mayroo N, Liu X, Norris J, Hannun YA, Bielawska A. Synthesis and bioevaluation of ω-N-amino analogs of B13 Bioorganic and Medicinal Chemistry. 17: 1840-1848. PMID 19217788 DOI: 10.1016/J.Bmc.2009.01.057  0.378
2009 Kitagaki H, Cowart LA, Matmati N, Montefusco D, Gandy J, de Avalos SV, Novgorodov SA, Zheng J, Obeid LM, Hannun YA. ISC1-dependent metabolic adaptation reveals an indispensable role for mitochondria in induction of nuclear genes during the diauxic shift in Saccharomyces cerevisiae. The Journal of Biological Chemistry. 284: 10818-30. PMID 19179331 DOI: 10.1074/Jbc.M805029200  0.319
2009 Yu H, Zeidan YH, Wu BX, Jenkins RW, Flotte TR, Hannun YA, Virella-Lowell I. Defective acid sphingomyelinase pathway with Pseudomonas aeruginosa infection in cystic fibrosis. American Journal of Respiratory Cell and Molecular Biology. 41: 367-75. PMID 19168701 DOI: 10.1165/Rcmb.2008-0295Oc  0.35
2009 Mahdy AE, Cheng JC, Li J, Elojeimy S, Meacham WD, Turner LS, Bai A, Gault CR, McPherson AS, Garcia N, Beckham TH, Saad A, Bielawska A, Bielawski J, Hannun YA, et al. Acid ceramidase upregulation in prostate cancer cells confers resistance to radiation: AC inhibition, a potential radiosensitizer. Molecular Therapy : the Journal of the American Society of Gene Therapy. 17: 430-8. PMID 19107118 DOI: 10.1038/Mt.2008.281  0.311
2009 Villa NY, Kupchak BR, Garitaonandia I, Smith JL, Alonso E, Alford C, Cowart LA, Hannun YA, Lyons TJ. Sphingolipids function as downstream effectors of a fungal PAQR. Molecular Pharmacology. 75: 866-75. PMID 19066337 DOI: 10.1124/Mol.108.049809  0.35
2009 Mukhopadhyay A, Saddoughi SA, Song P, Sultan I, Ponnusamy S, Senkal CE, Snook CF, Arnold HK, Sears RC, Hannun YA, Ogretmen B. Direct interaction between the inhibitor 2 and ceramide via sphingolipid-protein binding is involved in the regulation of protein phosphatase 2A activity and signaling. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. 23: 751-63. PMID 19028839 DOI: 10.1096/Fj.08-120550  0.418
2009 Bartke N, Hannun YA. Bioactive sphingolipids: Metabolism and function Journal of Lipid Research. 50: S91-S96. PMID 19017611 DOI: 10.1194/Jlr.R800080-Jlr200  0.42
2008 Montes LR, López DJ, Sot J, Bagatolli LA, Stonehouse MJ, Vasil ML, Wu BX, Hannun YA, Goñi FM, Alonso A. Ceramide-enriched membrane domains in red blood cells and the mechanism of sphingomyelinase-induced hot-cold hemolysis. Biochemistry. 47: 11222-30. PMID 18826261 DOI: 10.1021/Bi801139Z  0.362
2008 Zeidan YH, Jenkins RW, Korman JB, Liu X, Obeid LM, Norris JS, Hannun YA. Molecular targeting of acid ceramidase: implications to cancer therapy. Current Drug Targets. 9: 653-61. PMID 18691012 DOI: 10.2174/138945008785132358  0.322
2008 Chudakova DA, Zeidan YH, Wheeler BW, Yu J, Novgorodov SA, Kindy MS, Hannun YA, Gudz TI. Integrin-associated Lyn kinase promotes cell survival by suppressing acid sphingomyelinase activity. The Journal of Biological Chemistry. 283: 28806-16. PMID 18682390 DOI: 10.1074/Jbc.M803301200  0.367
2008 Jin J, Hou Q, Mullen TD, Zeidan YH, Bielawski J, Kraveka JM, Bielawska A, Obeid LM, Hannun YA, Hsu YT. Ceramide generated by sphingomyelin hydrolysis and the salvage pathway is involved in hypoxia/reoxygenation-induced Bax redistribution to mitochondria in NT-2 cells. The Journal of Biological Chemistry. 283: 26509-17. PMID 18676372 DOI: 10.1074/Jbc.M801597200  0.417
2008 Clarke CJ, Guthrie JM, Hannun YA. Regulation of neutral sphingomyelinase-2 (nSMase2) by tumor necrosis factor-α involves protein kinase C-δ in lung epithelial cells Molecular Pharmacology. 74: 1022-1032. PMID 18653803 DOI: 10.1124/Mol.108.046250  0.441
2008 Pata MO, Wu BX, Bielawski J, Xiong TC, Hannun YA, Ng CKY. Molecular cloning and characterization of OsCDase, a ceramidase enzyme from rice Plant Journal. 55: 1000-1009. PMID 18547394 DOI: 10.1111/J.1365-313X.2008.03569.X  0.312
2008 Zeidan YH, Jenkins RW, Hannun YA. Remodeling of cellular cytoskeleton by the acid sphingomyelinase/ceramide pathway Journal of Cell Biology. 181: 335-350. PMID 18426979 DOI: 10.1083/Jcb.200705060  0.418
2008 Panjarian S, Kozhaya L, Arayssi S, Yehia M, Bielawski J, Bielawska A, Usta J, Hannun YA, Obeid LM, Dbaibo GS. De novo N-palmitoylsphingosine synthesis is the major biochemical mechanism of ceramide accumulation following p53 up-regulation. Prostaglandins & Other Lipid Mediators. 86: 41-8. PMID 18400537 DOI: 10.1016/J.Prostaglandins.2008.02.004  0.45
2008 Shah C, Yang G, Lee I, Bielawski J, Hannun YA, Samad F. Protection from high fat diet-induced increase in ceramide in mice lacking plasminogen activator inhibitor 1 Journal of Biological Chemistry. 283: 13538-13548. PMID 18359942 DOI: 10.1074/Jbc.M709950200  0.32
2008 Misra S, Obeid LM, Hannun YA, Minamisawa S, Berger FG, Markwald RR, Toole BP, Ghatak S. Hyaluronan constitutively regulates activation of COX-2-mediated cell survival activity in intestinal epithelial and colon carcinoma cells Journal of Biological Chemistry. 283: 14335-14344. PMID 18326857 DOI: 10.1074/Jbc.M703811200  0.399
2008 Matmati N, Hannun YA. ISC1 (inositol phosphosphingolipid-phospholipase C), the yeast homologue of neutral sphingomyelinases Journal of Lipid Research. 49: 922-928. PMID 18305313 DOI: 10.1194/Jlr.R800004-Jlr200  0.407
2008 Hannun YA, Obeid LM. Principles of bioactive lipid signalling: lessons from sphingolipids. Nature Reviews. Molecular Cell Biology. 9: 139-50. PMID 18216770 DOI: 10.1038/Nrm2329  0.394
2008 Kitatani K, Idkowiak-Baldys J, Hannun YA. The sphingolipid salvage pathway in ceramide metabolism and signaling. Cellular Signalling. 20: 1010-8. PMID 18191382 DOI: 10.1016/J.Cellsig.2007.12.006  0.4
2008 Liu X, Elojeimy S, Turner LS, Mahdy AE, Zeidan YH, Bielawska A, Bielawski J, Dong JY, El-Zawahry AM, Guo GW, Hannun YA, Holman DH, Rubinchik S, Szulc Z, Keane TE, et al. Acid ceramidase inhibition: a novel target for cancer therapy. Frontiers in Bioscience : a Journal and Virtual Library. 13: 2293-8. PMID 17981711 DOI: 10.2741/2843  0.324
2008 Bielawska A, Bielawski J, Szulc ZM, Mayroo N, Liu X, Bai A, Elojeimy S, Rembiesa B, Pierce J, Norris JS, Hannun YA. Novel analogs of D-e-MAPP and B13. Part 2: signature effects on bioactive sphingolipids. Bioorganic & Medicinal Chemistry. 16: 1032-45. PMID 17881234 DOI: 10.1016/J.Bmc.2007.08.032  0.356
2008 Zeidan YH, Wu BX, Jenkins RW, Obeid LM, Hannun YA. A novel role for protein kinase Cdelta-mediated phosphorylation of acid sphingomyelinase in UV light-induced mitochondrial injury. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. 22: 183-93. PMID 17698617 DOI: 10.1096/fj.07-8967com  0.339
2008 Holman DH, Turner LS, El-Zawahry A, Elojeimy S, Liu X, Bielawski J, Szulc ZM, Norris K, Zeidan YH, Hannun YA, Bielawska A, Norris JS. Lysosomotropic acid ceramidase inhibitor induces apoptosis in prostate cancer cells. Cancer Chemotherapy and Pharmacology. 61: 231-42. PMID 17429631 DOI: 10.1007/S00280-007-0465-0  0.342
2007 Shi L, Bielawski J, Mu J, Dong H, Teng C, Zhang J, Yang X, Tomishige N, Hanada K, Hannun YA, Zuo J. Involvement of sphingoid bases in mediating reactive oxygen intermediate production and programmed cell death in Arabidopsis Cell Research. 17: 1030-1040. PMID 18059378 DOI: 10.1038/Cr.2007.100  0.421
2007 Marchesini N, Jones JA, Hannun YA. Confluence induced threonine41/serine45 phospho-β-catenin dephosphorylation via ceramide-mediated activation of PP1cγ Biochimica Et Biophysica Acta - Molecular and Cell Biology of Lipids. 1771: 1418-1428. PMID 17996206 DOI: 10.1016/J.Bbalip.2007.10.003  0.374
2007 Saad AF, Meacham WD, Bai A, Anelli V, Elojeimy S, Mahdy AE, Turner LS, Cheng J, Bielawska A, Bielawski J, Keane TE, Obeid LM, Hannun YA, Norris JS, Liu X. The functional effects of acid ceramidase overexpression in prostate cancer progression and resistance to chemotherapy. Cancer Biology & Therapy. 6: 1455-60. PMID 17881906 DOI: 10.4161/Cbt.6.9.4623  0.381
2007 Kitagaki H, Cowart LA, Matmati N, Vaena de Avalos S, Novgorodov SA, Zeidan YH, Bielawski J, Obeid LM, Hannun YA. Isc1 regulates sphingolipid metabolism in yeast mitochondria. Biochimica Et Biophysica Acta. 1768: 2849-61. PMID 17880915 DOI: 10.1016/J.Bbamem.2007.07.019  0.336
2007 D'Angelo G, Polishchuk E, Tullio GD, Santoro M, Campli AD, Godi A, West G, Bielawski J, Chuang CC, Van Der Spoel AC, Platt FM, Hannun YA, Polishchuk R, Mattjus P, De Matteis MA. Glycosphingolipid synthesis requires FAPP2 transfer of glucosylceramide Nature. 449: 62-67. PMID 17687330 DOI: 10.1038/Nature06097  0.334
2007 Karahatay S, Thomas K, Koybasi S, Senkal CE, Elojeimy S, Liu X, Bielawski J, Day TA, Gillespie MB, Sinha D, Norris JS, Hannun YA, Ogretmen B. Clinical relevance of ceramide metabolism in the pathogenesis of human head and neck squamous cell carcinoma (HNSCC): attenuation of C(18)-ceramide in HNSCC tumors correlates with lymphovascular invasion and nodal metastasis. Cancer Letters. 256: 101-11. PMID 17619081 DOI: 10.1016/J.Canlet.2007.06.003  0.312
2007 Zeidan YH, Hannun YA. Translational aspects of sphingolipid metabolism Trends in Molecular Medicine. 13: 327-336. PMID 17588815 DOI: 10.1016/J.Molmed.2007.06.002  0.33
2007 Coatrieux C, Sanson M, Negre-Salvayre A, Parini A, Hannun Y, Itohara S, Salvayre R, Auge N. MAO-A-induced mitogenic signaling is mediated by reactive oxygen species, MMP-2, and the sphingolipid pathway. Free Radical Biology & Medicine. 43: 80-9. PMID 17561096 DOI: 10.1016/J.Freeradbiomed.2007.03.036  0.316
2007 Kitatani K, Idkowiak-Baldys J, Hannun YA. Mechanism of inhibition of sequestration of protein kinase C alpha/betaII by ceramide. Roles of ceramide-activated protein phosphatases and phosphorylation/dephosphorylation of protein kinase C alpha/betaII on threonine 638/641. The Journal of Biological Chemistry. 282: 20647-56. PMID 17504762 DOI: 10.1074/Jbc.M609162200  0.402
2007 Elojeimy S, Liu X, McKillop JC, El-Zawahry AM, Holman DH, Cheng JY, Meacham WD, Mahdy AE, Saad AF, Turner LS, Cheng J, A Day T, Dong JY, Bielawska A, Hannun YA, et al. Role of acid ceramidase in resistance to FasL: therapeutic approaches based on acid ceramidase inhibitors and FasL gene therapy. Molecular Therapy : the Journal of the American Society of Gene Therapy. 15: 1259-63. PMID 17426710 DOI: 10.1038/Sj.Mt.6300167  0.396
2007 Cowart LA, Hannun YA. Selective substrate supply in the regulation of yeast de novo sphingolipid synthesis Journal of Biological Chemistry. 282: 12330-12340. PMID 17322298 DOI: 10.1074/Jbc.M700685200  0.319
2007 Senkal CE, Ponnusamy S, Rossi MJ, Bialewski J, Sinha D, Jiang JC, Jazwinski SM, Hannun YA, Ogretmen B. Role of human longevity assurance gene 1 and C18-ceramide in chemotherapy-induced cell death in human head and neck squamous cell carcinomas. Molecular Cancer Therapeutics. 6: 712-22. PMID 17308067 DOI: 10.1158/1535-7163.Mct-06-0558  0.434
2007 Zeidan YH, Hannun YA. Activation of acid sphingomyelinase by protein kinase Cδ-mediated phosphorylation Journal of Biological Chemistry. 282: 11549-11561. PMID 17303575 DOI: 10.1074/Jbc.M609424200  0.428
2007 Kraveka JM, Li L, Szulc ZM, Bielawski J, Ogretmen B, Hannun YA, Obeid LM, Bielawska A. Involvement of dihydroceramide desaturase in cell cycle progression in human neuroblastoma cells. The Journal of Biological Chemistry. 282: 16718-28. PMID 17283068 DOI: 10.1074/Jbc.M700647200  0.46
2007 Tani M, Hannun YA. Neutral sphingomyelinase 2 is palmitoylated on multiple cysteine residues: Role of palmitoylation in subcellular localization Journal of Biological Chemistry. 282: 10047-10056. PMID 17272284 DOI: 10.1074/Jbc.M611249200  0.303
2007 Alvi F, Idkowiak-Baldys J, Baldys A, Raymond JR, Hannun YA. Regulation of membrane trafficking and endocytosis by protein kinase C: Emerging role of the pericentrion, a novel protein kinase C-dependent subset of recycling endosomes Cellular and Molecular Life Sciences. 64: 263-270. PMID 17180302 DOI: 10.1007/S00018-006-6363-5  0.395
2007 Martín SF, Sawai H, Villalba JM, Hannun YA. Redox regulation of neutral sphingomyelinase-1 activity in HEK293 cells through a GSH-dependent mechanism. Archives of Biochemistry and Biophysics. 459: 295-300. PMID 17169322 DOI: 10.1016/J.Abb.2006.11.007  0.414
2007 Wu BX, Snook CF, Tani M, Büllesbach EE, Hannun YA. Large-scale purification and characterization of recombinant Pseudomonas ceramidase: Regulation by calcium Journal of Lipid Research. 48: 600-608. PMID 17164222 DOI: 10.1194/Jlr.M600423-Jlr200  0.307
2007 Rizzieri KE, Hannun YA. Sphingolipid metabolism, apoptosis and resistance to cytotoxic agents: can we interfere? Drug Resistance Updates : Reviews and Commentaries in Antimicrobial and Anticancer Chemotherapy. 1: 359-76. PMID 17092818 DOI: 10.1016/S1368-7646(98)80012-5  0.406
2007 Clarke CJ, Truong TG, Hannun YA. Role for neutral sphingomyelinase-2 in tumor necrosis factor α-stimulated expression of vascular cell adhesion molecule-1 (VCAM) and intercellular adhesion molecule-1 (ICAM) in lung epithelial cells: p38 MAPK is an upstream regulator of nSMase2 Journal of Biological Chemistry. 282: 1384-1396. PMID 17085432 DOI: 10.1074/Jbc.M609216200  0.365
2007 Cowart LA, Hannun YA, Obeid LM. Metabolism and function of sphingolipids in saccharomyces cerevisiae: Relevance to cancer research Yeast as a Tool in Cancer Research. 191-210. DOI: 10.1007/978-1-4020-5963-6_8  0.326
2006 Kitatani K, Idkowiak-Baldys J, Bielawski J, Taha TA, Jenkins RW, Senkal CE, Ogretmen B, Obeid LM, Hannun YA. Protein kinase C-induced activation of a ceramide/protein phosphatase 1 pathway leading to dephosphorylation of p38 MAPK. The Journal of Biological Chemistry. 281: 36793-802. PMID 17030510 DOI: 10.1074/Jbc.M608137200  0.412
2006 Clarke CJ, Snook CF, Tani M, Matmati N, Marchesini N, Hannun YA. The extended family of neutral sphingomyelinases Biochemistry. 45: 11247-11256. PMID 16981685 DOI: 10.1021/Bi061307Z  0.344
2006 Spassieva S, Seo JG, Jiang JC, Bielawski J, Alvarez-Vasquez F, Jazwinski SM, Hannun YA, Obeid LM. Necessary role for the Lag1p motif in (dihydro)ceramide synthase activity. The Journal of Biological Chemistry. 281: 33931-8. PMID 16951403 DOI: 10.1074/Jbc.M608092200  0.383
2006 Clarke CJ, Hannun YA. Neutral sphingomyelinases and nSMase2: Bridging the gaps Biochimica Et Biophysica Acta - Biomembranes. 1758: 1893-1901. PMID 16938269 DOI: 10.1016/J.Bbamem.2006.06.025  0.375
2006 Liu X, Zeidan YH, Elojeimy S, Holman DH, El-Zawahry AM, Guo GW, Bielawska A, Bielawski J, Szulc Z, Rubinchik S, Dong JY, Keane TE, Tavassoli M, Hannun YA, Norris JS. Involvement of sphingolipids in apoptin-induced cell killing. Molecular Therapy : the Journal of the American Society of Gene Therapy. 14: 627-36. PMID 16926120 DOI: 10.1016/J.Ymthe.2006.07.001  0.463
2006 Szulc ZM, Bielawski J, Gracz H, Gustilo M, Mayroo N, Hannun YA, Obeid LM, Bielawska A. Tailoring structure-function and targeting properties of ceramides by site-specific cationization. Bioorganic & Medicinal Chemistry. 14: 7083-104. PMID 16919460 DOI: 10.1016/J.Bmc.2006.07.016  0.395
2006 Snook CF, Jones JA, Hannun YA. Sphingolipid-binding proteins Biochimica Et Biophysica Acta - Molecular and Cell Biology of Lipids. 1761: 927-946. PMID 16901751 DOI: 10.1016/J.Bbalip.2006.06.004  0.317
2006 Elojeimy S, Holman DH, Liu X, El-Zawahry A, Villani M, Cheng JC, Mahdy A, Zeidan Y, Bielwaska A, Hannun YA, Norris JS. New insights on the use of desipramine as an inhibitor for acid ceramidase. Febs Letters. 580: 4751-6. PMID 16901483 DOI: 10.1016/J.Febslet.2006.07.071  0.34
2006 Dindo D, Dahm F, Szulc Z, Bielawska A, Obeid LM, Hannun YA, Graf R, Clavien PA. Cationic long-chain ceramide LCL-30 induces cell death by mitochondrial targeting in SW403 cells. Molecular Cancer Therapeutics. 5: 1520-9. PMID 16818511 DOI: 10.1158/1535-7163.Mct-05-0513  0.363
2006 Zeidan YH, Pettus BJ, Elojeimy S, Taha T, Obeid LM, Kawamori T, Norris JS, Hannun YA. Acid ceramidase but not acid sphingomyelinase is required for tumor necrosis factor-{alpha}-induced PGE2 production. The Journal of Biological Chemistry. 281: 24695-703. PMID 16803890 DOI: 10.1074/Jbc.M604713200  0.388
2006 El Alwani M, Wu BX, Obeid LM, Hannun YA. Bioactive sphingolipids in the modulation of the inflammatory response. Pharmacology & Therapeutics. 112: 171-83. PMID 16759708 DOI: 10.1016/J.Pharmthera.2006.04.004  0.312
2006 Idkowiak-Baldys J, Becker KP, Kitatani K, Hannun YA. Dynamic sequestration of the recycling compartment by classical protein kinase C. The Journal of Biological Chemistry. 281: 22321-31. PMID 16751194 DOI: 10.1074/Jbc.M512540200  0.412
2006 Taha TA, Hannun YA, Obeid LM. Sphingosine kinase: biochemical and cellular regulation and role in disease. Journal of Biochemistry and Molecular Biology. 39: 113-31. PMID 16584625 DOI: 10.5483/Bmbrep.2006.39.2.113  0.416
2006 Senkal CE, Ponnusamy S, Rossi MJ, Sundararaj K, Szulc Z, Bielawski J, Bielawska A, Meyer M, Cobanoglu B, Koybasi S, Sinha D, Day TA, Obeid LM, Hannun YA, Ogretmen B. Potent antitumor activity of a novel cationic pyridinium-ceramide alone or in combination with gemcitabine against human head and neck squamous cell carcinomas in vitro and in vivo. The Journal of Pharmacology and Experimental Therapeutics. 317: 1188-99. PMID 16510697 DOI: 10.1124/Jpet.106.101949  0.352
2006 Taha TA, Kitatani K, El-Alwani M, Bielawski J, Hannun YA, Obeid LM. Loss of sphingosine kinase-1 activates the intrinsic pathway of programmed cell death: modulation of sphingolipid levels and the induction of apoptosis. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. 20: 482-4. PMID 16507765 DOI: 10.1096/Fj.05-4412Fje  0.474
2006 Kono M, Dreier JL, Ellis JM, Allende ML, Kalkofen DN, Sanders KM, Bielawski J, Bielawska A, Hannun YA, Proia RL. Neutral ceramidase encoded by the Asah2 gene is essential for the intestinal degradation of sphingolipids. The Journal of Biological Chemistry. 281: 7324-31. PMID 16380386 DOI: 10.1074/Jbc.M508382200  0.38
2006 Kawamori T, Osta W, Johnson KR, Pettus BJ, Bielawski J, Tanaka T, Wargovich MJ, Reddy BS, Hannun YA, Obeid LM, Zhou D. Sphingosine kinase 1 is up-regulated in colon carcinogenesis. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. 20: 386-8. PMID 16319132 DOI: 10.1096/Fj.05-4331Fje  0.366
2006 Galadari S, Wu BX, Mao C, Roddy P, El Bawab S, Hannun YA. Identification of a novel amidase motif in neutral ceramidase. The Biochemical Journal. 393: 687-95. PMID 16229686 DOI: 10.1042/Bj20050682  0.319
2006 Sultan I, Senkal CE, Ponnusamy S, Bielawski J, Szulc Z, Bielawska A, Hannun YA, Ogretmen B. Regulation of the sphingosine-recycling pathway for ceramide generation by oxidative stress, and its role in controlling c-Myc/Max function. The Biochemical Journal. 393: 513-21. PMID 16201965 DOI: 10.1042/Bj20051083  0.402
2006 Cowart LA, Okamoto Y, Lu X, Hannun YA. Distinct roles for de novo versus hydrolytic pathways of sphingolipid biosynthesis in Saccharomyces cerevisiae. The Biochemical Journal. 393: 733-40. PMID 16201964 DOI: 10.1042/Bj20050643  0.393
2006 El-Zawahry AM, Holman D, Liu X, ElOjeimy S, Sudarshan S, Bissada NK, Rashwan H, Szulc Z, Bielwaska A, Keane T, Hannun Y, Norris J. 938. Ceramide May Have a Role in Sensitizing ACHN Renal Cancer Cells (RCC) to Fas Induced Apoptosis Molecular Therapy. 13: S362. DOI: 10.1016/J.Ymthe.2006.08.1029  0.347
2006 Mahdy AE, Liu X, ELojeimy SN, Bielaswka A, Hannun YA, Keanne TE, El-Zawahry AM, Norris JS. 928. Reversal of PPC1 Prostate Cancer Cells Radioresistance by Degradation of Acid Ceramidase Using the Lysosomotropic Drug LCL385 Molecular Therapy. 13: S358-S359. DOI: 10.1016/J.Ymthe.2006.08.1019  0.371
2006 El-Zawahry AM, Liu X, ElOjeimy S, Holma D, Elmahdy A, Bissada NK, Rashwan HM, Szulc Z, Bielwaska A, Bielwaski J, Keane T, Hannun Y, Norris J. 924. D-MAPP Analogue, LCL-204 Sensitizes DU145 Prostate Cancer Cells (PCa) to FasL Gene Therapy through Down-Regulation of Survivin Molecular Therapy. 13: S357. DOI: 10.1016/J.Ymthe.2006.08.1015  0.344
2006 Liu X, Guo G, Elojeimy SN, Holman DH, Mahdy A, Bielawska A, Bielawski J, Rubinchik S, Dong J, Keane T, Tavassoli M, Hannun YA, Norris JN. 49. Inhibition of Acid Ceramidase Expression by Small Interfering RNA Sensitize Human Prostae Cancer Cells to Apoptin Induced Cell Death Molecular Therapy. 13: S21. DOI: 10.1016/J.Ymthe.2006.08.063  0.391
2006 Zeidan Y, Marchesini N, Hannun YA. Overview of acid and neutral sphingomyelinases in cell signaling Sphingolipid Biology. 167-181. DOI: 10.1007/4-431-34200-1_12  0.311
2005 Osawa Y, Hannun YA, Proia RL, Brenner DA. Roles of AKT and sphingosine kinase in the antiapoptotic effects of bile duct ligation in mouse liver. Hepatology (Baltimore, Md.). 42: 1320-8. PMID 16317686 DOI: 10.1002/Hep.20967  0.305
2005 Bu S, Yamanaka M, Pei H, Bielawska A, Bielawski J, Hannun YA, Obeid L, Trojanowska M. Dihydrosphingosine 1-phosphate stimulates MMP1 gene expression via activation of ERK1/2-Ets1 pathway in human fibroblasts. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. 20: 184-6. PMID 16278291 DOI: 10.1096/Fj.05-4646Fje  0.346
2005 Voelkel-Johnson C, Hannun YA, El-Zawahry A. Resistance to TRAIL is associated with defects in ceramide signaling that can be overcome by exogenous C6-ceramide without requiring down-regulation of cellular FLICE inhibitory protein. Molecular Cancer Therapeutics. 4: 1320-7. PMID 16170023 DOI: 10.1158/1535-7163.Mct-05-0086  0.443
2005 Osawa Y, Uchinami H, Bielawski J, Schwabe RF, Hannun YA, Brenner DA. Roles for C16-ceramide and sphingosine 1-phosphate in regulating hepatocyte apoptosis in response to tumor necrosis factor-alpha. The Journal of Biological Chemistry. 280: 27879-87. PMID 15946935 DOI: 10.1074/Jbc.M503002200  0.394
2005 Becker KP, Hannun YA. Protein kinase C and phospholipase D: intimate interactions in intracellular signaling. Cellular and Molecular Life Sciences : Cmls. 62: 1448-61. PMID 15924269 DOI: 10.1007/S00018-005-4531-7  0.41
2005 Pettus BJ, Kitatani K, Chalfant CE, Taha TA, Kawamori T, Bielawski J, Obeid LM, Hannun YA. The coordination of prostaglandin E2 production by sphingosine-1-phosphate and ceramide-1-phosphate. Molecular Pharmacology. 68: 330-5. PMID 15900018 DOI: 10.1124/Mol.104.008722  0.357
2005 Novgorodov SA, Szulc ZM, Luberto C, Jones JA, Bielawski J, Bielawska A, Hannun YA, Obeid LM. Positively charged ceramide is a potent inducer of mitochondrial permeabilization. The Journal of Biological Chemistry. 280: 16096-105. PMID 15722351 DOI: 10.1074/Jbc.M411707200  0.324
2005 Taha TA, Kitatani K, Bielawski J, Cho W, Hannun YA, Obeid LM. Tumor necrosis factor induces the loss of sphingosine kinase-1 by a cathepsin B-dependent mechanism. The Journal of Biological Chemistry. 280: 17196-202. PMID 15710602 DOI: 10.1074/Jbc.M413744200  0.405
2005 Hu W, Xu R, Zhang G, Jin J, Szulc ZM, Bielawski J, Hannun YA, Obeid LM, Mao C. Golgi fragmentation is associated with ceramide-induced cellular effects. Molecular Biology of the Cell. 16: 1555-67. PMID 15647381 DOI: 10.1091/Mbc.E04-07-0594  0.352
2005 Rossi MJ, Sundararaj K, Koybasi S, Phillips MS, Szulc ZM, Bielawska A, Day TA, Obeid LM, Hannun YA, Ogretmen B. Inhibition of growth and telomerase activity by novel cationic ceramide analogs with high solubility in human head and neck squamous cell carcinoma cells. Otolaryngology--Head and Neck Surgery : Official Journal of American Academy of Otolaryngology-Head and Neck Surgery. 132: 55-62. PMID 15632910 DOI: 10.1016/J.Otohns.2004.08.015  0.367
2005 Vaena de Avalos S, Su X, Zhang M, Okamoto Y, Dowhan W, Hannun YA. The phosphatidylglycerol/cardiolipin biosynthetic pathway is required for the activation of inositol phosphosphingolipid phospholipase C, Isc1p, during growth of Saccharomyces cerevisiae. The Journal of Biological Chemistry. 280: 7170-7. PMID 15611094 DOI: 10.1074/Jbc.M411058200  0.37
2005 Becker KP, Kitatani K, Idkowiak-Baldys J, Bielawski J, Hannun YA. Selective inhibition of juxtanuclear translocation of protein kinase C betaII by a negative feedback mechanism involving ceramide formed from the salvage pathway. The Journal of Biological Chemistry. 280: 2606-12. PMID 15546881 DOI: 10.1074/Jbc.M409066200  0.48
2005 Birbes H, Luberto C, Hsu YT, El Bawab S, Hannun YA, Obeid LM. A mitochondrial pool of sphingomyelin is involved in TNFalpha-induced Bax translocation to mitochondria. The Biochemical Journal. 386: 445-51. PMID 15516208 DOI: 10.1042/Bj20041627  0.333
2005 El-Zawahry A, Holman D, Liu X, Elojaem S, Bielawaska A, Bielwaski J, Szulc Z, Hannun Y, Norris JS. 1011. A Combination of Ceramide Analogue and FasL Gene Therapy Can Be a Potential Novel Therapy for Prostate Cancer Molecular Therapy. 11. DOI: 10.1016/J.Ymthe.2005.07.558  0.314
2004 Pettus BJ, Chalfant CE, Hannun YA. Sphingolipids in inflammation: Roles and implications Current Molecular Medicine. 4: 405-418. PMID 15354871 DOI: 10.2174/1566524043360573  0.414
2004 Koybasi S, Senkal CE, Sundararaj K, Spassieva S, Bielawski J, Osta W, Day TA, Jiang JC, Jazwinski SM, Hannun YA, Obeid LM, Ogretmen B. Defects in cell growth regulation by C18:0-ceramide and longevity assurance gene 1 in human head and neck squamous cell carcinomas Journal of Biological Chemistry. 279: 44311-44319. PMID 15317812 DOI: 10.1074/Jbc.M406920200  0.394
2004 Osta WA, Chen Y, Mikhitarian K, Mitas M, Salem M, Hannun YA, Cole DJ, Gillanders WE. EpCAM is overexpressed in breast cancer and is a potential target for breast cancer gene therapy. Cancer Research. 64: 5818-24. PMID 15313925 DOI: 10.1158/0008-5472.Can-04-0754  0.307
2004 Futerman AH, Hannun YA. The complex life of simple sphingolipids. Embo Reports. 5: 777-82. PMID 15289826 DOI: 10.1038/Sj.Embor.7400208  0.346
2004 Ogretmen B, Hannun YA. Biologically active sphingolipids in cancer pathogenesis and treatment. Nature Reviews. Cancer. 4: 604-16. PMID 15286740 DOI: 10.1038/Nrc1411  0.373
2004 Becker KP, Hannun YA. Isoenzyme-specific translocation of protein kinase C (PKC)betaII and not PKCbetaI to a juxtanuclear subset of recycling endosomes: involvement of phospholipase D. The Journal of Biological Chemistry. 279: 28251-6. PMID 15067001 DOI: 10.1074/Jbc.M400770200  0.37
2004 Marchesini N, Hannun YA. Acid and neutral sphingomyelinases: roles and mechanisms of regulation. Biochemistry and Cell Biology = Biochimie Et Biologie Cellulaire. 82: 27-44. PMID 15052326 DOI: 10.1139/O03-091  0.397
2004 Marchesini N, Osta W, Bielawski J, Luberto C, Obeid LM, Hannun YA. Role for mammalian neutral sphingomyelinase 2 in confluence-induced growth arrest of MCF7 cells. The Journal of Biological Chemistry. 279: 25101-11. PMID 15051724 DOI: 10.1074/Jbc.M313662200  0.439
2004 Heung LJ, Luberto C, Plowden A, Hannun YA, Del Poeta M. The sphingolipid pathway regulates Pkc1 through the formation of diacylglycerol in Cryptococcus neoformans. The Journal of Biological Chemistry. 279: 21144-53. PMID 15014071 DOI: 10.1074/Jbc.M312995200  0.438
2004 Taha TA, Osta W, Kozhaya L, Bielawski J, Johnson KR, Gillanders WE, Dbaibo GS, Hannun YA, Obeid LM. Down-regulation of sphingosine kinase-1 by DNA damage: dependence on proteases and p53. The Journal of Biological Chemistry. 279: 20546-54. PMID 14988393 DOI: 10.1074/Jbc.M401259200  0.426
2004 Meng A, Luberto C, Meier P, Bai A, Yang X, Hannun YA, Zhou D. Sphingomyelin synthase as a potential target for D609-induced apoptosis in U937 human monocytic leukemia cells. Experimental Cell Research. 292: 385-92. PMID 14697345 DOI: 10.1016/J.Yexcr.2003.10.001  0.4
2004 Pettus BJ, Bielawska A, Subramanian P, Wijesinghe DS, Maceyka M, Leslie CC, Evans JH, Freiberg J, Roddy P, Hannun YA, Chalfant CE. Ceramide 1-phosphate is a direct activator of cytosolic phospholipase A2. The Journal of Biological Chemistry. 279: 11320-6. PMID 14676210 DOI: 10.1074/Jbc.M309262200  0.366
2004 Chalfant CE, Szulc Z, Roddy P, Bielawska A, Hannun YA. The structural requirements for ceramide activation of serine-threonine protein phosphatases. Journal of Lipid Research. 45: 496-506. PMID 14657198 DOI: 10.1194/Jlr.M300347-Jlr200  0.357
2004 Sundararaj KP, Wood RE, Ponnusamy S, Salas AM, Szulc Z, Bielawska A, Obeid LM, Hannun YA, Ogretmen B. Rapid shortening of telomere length in response to ceramide involves the inhibition of telomere binding activity of nuclear glyceraldehyde-3-phosphate dehydrogenase. The Journal of Biological Chemistry. 279: 6152-62. PMID 14630908 DOI: 10.1074/Jbc.M310549200  0.343
2004 Norris JS, Holman DH, El-Zawahry AM, Schwartz DA, Bielawska A, Obeid LM, Hannun YA, Dong J. 676. A Role for Ceramide in AdGFPFasLTET Gene Therapy|[ast]| Molecular Therapy. 9. DOI: 10.1016/J.Ymthe.2004.06.640  0.355
2004 Hannun YA, Luberto C. Lipid Metabolism: Ceramide Transfer Protein Adds a New Dimension Current Biology. 14: R163-R165. DOI: 10.1016/J.Cub.2004.01.049  0.342
2003 Vaena de Avalos S, Okamoto Y, Hannun YA. Activation and localization of inositol phosphosphingolipid phospholipase C, Isc1p, to the mitochondria during growth of Saccharomyces cerevisiae. The Journal of Biological Chemistry. 279: 11537-45. PMID 14699160 DOI: 10.1074/Jbc.M309586200  0.345
2003 Becker KP, Hannun YA. cPKC-dependent sequestration of membrane-recycling components in a subset of recycling endosomes. The Journal of Biological Chemistry. 278: 52747-54. PMID 14527960 DOI: 10.1074/Jbc.M305228200  0.375
2003 Luberto C, Martinez-Mariño B, Taraskiewicz D, Bolaños B, Chitano P, Toffaletti DL, Cox GM, Perfect JR, Hannun YA, Balish E, Del Poeta M. Identification of App1 as a regulator of phagocytosis and virulence of Cryptococcus neoformans. The Journal of Clinical Investigation. 112: 1080-94. PMID 14523045 DOI: 10.1172/Jci18309  0.381
2003 Pettus BJ, Bielawski J, Porcelli AM, Reames DL, Johnson KR, Morrow J, Chalfant CE, Obeid LM, Hannun YA. The sphingosine kinase 1/sphingosine-1-phosphate pathway mediates COX-2 induction and PGE2 production in response to TNF-alpha. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. 17: 1411-21. PMID 12890694 DOI: 10.1096/Fj.02-1038Com  0.382
2003 Pettus BJ, Bielawska A, Spiegel S, Roddy P, Hannun YA, Chalfant CE. Ceramide kinase mediates cytokine- and calcium ionophore-induced arachidonic acid release. The Journal of Biological Chemistry. 278: 38206-13. PMID 12855693 DOI: 10.1074/Jbc.M304816200  0.38
2003 Okamoto Y, Vaena de Avalos S, Hannun YA. Functional analysis of ISC1 by site-directed mutagenesis. Biochemistry. 42: 7855-62. PMID 12820895 DOI: 10.1021/Bi0341354  0.305
2003 Luberto C, Stonehouse MJ, Collins EA, Marchesini N, El-Bawab S, Vasil AI, Vasil ML, Hannun YA. Purification, characterization, and identification of a sphingomyelin synthase from Pseudomonas aeruginosa. PlcH is a multifunctional enzyme. The Journal of Biological Chemistry. 278: 32733-43. PMID 12799377 DOI: 10.1074/Jbc.M300932200  0.344
2003 Cowart LA, Okamoto Y, Pinto FR, Gandy JL, Almeida JS, Hannun YA. Roles for sphingolipid biosynthesis in mediation of specific programs of the heat stress response determined through gene expression profiling. The Journal of Biological Chemistry. 278: 30328-38. PMID 12740364 DOI: 10.1074/Jbc.M300656200  0.344
2003 Schanberg SM, Ingledue VF, Lee JY, Hannun YA, Bartolome JV. PKC alpha mediates maternal touch regulation of growth-related gene expression in infant rats. Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology. 28: 1026-30. PMID 12700701 DOI: 10.1038/Sj.Npp.1300125  0.331
2003 Hyer ML, Sudarshan S, Schwartz DA, Hannun Y, Dong JY, Norris JS. Quantification and characterization of the bystander effect in prostate cancer cells following adenovirus-mediated FasL expression. Cancer Gene Therapy. 10: 330-9. PMID 12679806 DOI: 10.1038/Sj.Cgt.7700576  0.388
2003 Kroesen BJ, Jacobs S, Pettus BJ, Sietsma H, Kok JW, Hannun YA, de Leij LF. BcR-induced apoptosis involves differential regulation of C16 and C24-ceramide formation and sphingolipid-dependent activation of the proteasome. The Journal of Biological Chemistry. 278: 14723-31. PMID 12578840 DOI: 10.1074/Jbc.M210756200  0.398
2003 Marchesini N, Luberto C, Hannun YA. Biochemical properties of mammalian neutral sphingomyelinase 2 and its role in sphingolipid metabolism. The Journal of Biological Chemistry. 278: 13775-83. PMID 12566438 DOI: 10.1074/Jbc.M212262200  0.451
2003 Cowart LA, Szulc Z, Bielawska A, Hannun YA. Structural determinants of sphingolipid recognition by commercially available anti-ceramide antibodies. Journal of Lipid Research. 43: 2042-8. PMID 12454264 DOI: 10.1194/Jlr.M200241-Jlr200  0.333
2002 Argraves KM, Obeid LM, Hannun YA. Sphingolipids in vascular biology. Advances in Experimental Medicine and Biology. 507: 439-44. PMID 12664623 DOI: 10.1007/978-1-4615-0193-0_68  0.762
2002 Pettus BJ, Chalfant CE, Hannun YA. Ceramide in apoptosis: an overview and current perspectives. Biochimica Et Biophysica Acta. 1585: 114-25. PMID 12531544 DOI: 10.1016/S1388-1981(02)00331-1  0.346
2002 Okamoto Y, Obeid LM, Hannun YA. Bcl-xL interrupts oxidative activation of neutral sphingomyelinase. Febs Letters. 530: 104-8. PMID 12387875 DOI: 10.1016/S0014-5793(02)03435-X  0.413
2002 Luberto C, Kraveka JM, Hannun YA. Ceramide regulation of apoptosis versus differentiation: a walk on a fine line. Lessons from neurobiology. Neurochemical Research. 27: 609-17. PMID 12374196 DOI: 10.1023/A:1020267831851  0.407
2002 Okamoto Y, Vaena De Avalos S, Hannun YA. Structural requirements for selective binding of ISC1 to anionic phospholipids. The Journal of Biological Chemistry. 277: 46470-7. PMID 12244059 DOI: 10.1074/Jbc.M207779200  0.364
2002 Jenkins GM, Cowart LA, Signorelli P, Pettus BJ, Chalfant CE, Hannun YA. Acute activation of de novo sphingolipid biosynthesis upon heat shock causes an accumulation of ceramide and subsequent dephosphorylation of SR proteins. The Journal of Biological Chemistry. 277: 42572-8. PMID 12200446 DOI: 10.1074/Jbc.M207346200  0.656
2002 Luberto C, Hassler DF, Signorelli P, Okamoto Y, Sawai H, Boros E, Hazen-Martin DJ, Obeid LM, Hannun YA, Smith GK. Inhibition of tumor necrosis factor-induced cell death in MCF7 by a novel inhibitor of neutral sphingomyelinase. The Journal of Biological Chemistry. 277: 41128-39. PMID 12154098 DOI: 10.1074/Jbc.M206747200  0.417
2002 Johnson KR, Becker KP, Facchinetti MM, Hannun YA, Obeid LM. PKC-dependent activation of sphingosine kinase 1 and translocation to the plasma membrane. Extracellular release of sphingosine-1-phosphate induced by phorbol 12-myristate 13-acetate (PMA). The Journal of Biological Chemistry. 277: 35257-62. PMID 12124383 DOI: 10.1074/Jbc.M203033200  0.43
2002 Birbes H, El Bawab S, Obeid LM, Hannun YA. Mitochondria and ceramide: intertwined roles in regulation of apoptosis. Advances in Enzyme Regulation. 42: 113-29. PMID 12123710 DOI: 10.1016/S0065-2571(01)00026-7  0.34
2002 Hannun YA, Obeid LM. The Ceramide-centric universe of lipid-mediated cell regulation: stress encounters of the lipid kind. The Journal of Biological Chemistry. 277: 25847-50. PMID 12011103 DOI: 10.1074/Jbc.R200008200  0.338
2002 Raisova M, Goltz G, Bektas M, Bielawska A, Riebeling C, Hossini AM, Eberle J, Hannun YA, Orfanos CE, Geilen CC. Bcl-2 overexpression prevents apoptosis induced by ceramidase inhibitors in malignant melanoma and HaCaT keratinocytes. Febs Letters. 516: 47-52. PMID 11959101 DOI: 10.1016/S0014-5793(02)02472-9  0.381
2002 Jones JA, Hannun YA. Tight binding inhibition of protein phosphatase-1 by phosphatidic acid. Specificity of inhibition by the phospholipid. The Journal of Biological Chemistry. 277: 15530-8. PMID 11856740 DOI: 10.1074/Jbc.M111555200  0.339
2002 Ogretmen B, Pettus BJ, Rossi MJ, Wood R, Usta J, Szulc Z, Bielawska A, Obeid LM, Hannun YA. Biochemical mechanisms of the generation of endogenous long chain ceramide in response to exogenous short chain ceramide in the A549 human lung adenocarcinoma cell line. Role for endogenous ceramide in mediating the action of exogenous ceramide. The Journal of Biological Chemistry. 277: 12960-9. PMID 11815611 DOI: 10.1074/Jbc.M110699200  0.412
2002 Chalfant CE, Rathman K, Pinkerman RL, Wood RE, Obeid LM, Ogretmen B, Hannun YA. De novo ceramide regulates the alternative splicing of caspase 9 and Bcl-x in A549 lung adenocarcinoma cells. Dependence on protein phosphatase-1. The Journal of Biological Chemistry. 277: 12587-95. PMID 11801602 DOI: 10.1074/Jbc.M112010200  0.389
2002 Birbes H, El Bawab S, Hannun YA, Obeid LM. Selective hydrolysis of a mitochondrial pool of sphingomyelin induces apoptosis. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. 15: 2669-79. PMID 11726543 DOI: 10.1096/fj.01-0539com  0.32
2002 Signorelli P, Hannun YA. Analysis and quantitation of ceramide. Methods in Enzymology. 345: 275-94. PMID 11665612 DOI: 10.1016/S0076-6879(02)45023-9  0.432
2001 Ogretmen B, Hannun YA. Updates on functions of ceramide in chemotherapy-induced cell death and in multidrug resistance Drug Resistance Updates. 4: 368-377. PMID 12030784 DOI: 10.1054/Drup.2001.0225  0.39
2001 Bielawska A, Perry DK, Hannun YA. Determination of ceramides and diglycerides by the diglyceride kinase assay Analytical Biochemistry. 298: 141-150. PMID 11757501 DOI: 10.1006/Abio.2001.5342  0.303
2001 Hayter HL, Pettus BJ, Ito F, Obeid LM, Hannun YA. TNFalpha-induced glutathione depletion lies downstream of cPLA(2) in L929 cells. Febs Letters. 507: 151-6. PMID 11684089 DOI: 10.1016/S0014-5793(01)02967-2  0.792
2001 Dbaibo GS, El-Assaad W, Krikorian A, Liu B, Diab K, Idriss NZ, El-Sabban M, Driscoll TA, Perry DK, Hannun YA. Ceramide generation by two distinct pathways in tumor necrosis factor α-induced cell death Febs Letters. 503: 7-12. PMID 11513845 DOI: 10.1016/S0014-5793(01)02625-4  0.428
2001 Chalfant CE, Ogretmen B, Galadari S, Kroesen BJ, Pettus BJ, Hannun YA. FAS Activation Induces Dephosphorylation of SR Proteins: Dependence on the de novo generation of ceramide and activation of protein phosphatase 1 Journal of Biological Chemistry. 276: 44848-44855. PMID 11502750 DOI: 10.1074/Jbc.M106291200  0.426
2001 Boujaoude LC, Bradshaw-Wilder C, Mao C, Cohn J, Ogretmen B, Hannun YA, Obeid LM. Cystic fibrosis transmembrane regulator regulates uptake of sphingoid base phosphates and lysophosphatidic acid: Modulation of cellular activity of sphingosine 1-phosphate Journal of Biological Chemistry. 276: 35258-35264. PMID 11443135 DOI: 10.1074/Jbc.M105442200  0.429
2001 Ogretmen B, Kraveka JM, Schady D, Usta J, Hannun YA, Obeid LM. Molecular Mechanisms of Ceramide-mediated Telomerase Inhibition in the A549 Human Lung Adenocarcinoma Cell Line Journal of Biological Chemistry. 276: 32506-32514. PMID 11441001 DOI: 10.1074/Jbc.M101350200  0.405
2001 Ogretmen B, Schady D, Usta J, Wood R, Kraveka JM, Luberto C, Birbes H, Hannun YA, Obeid LM. Role of Ceramide in Mediating the Inhibition of Telomerase Activity in A549 Human Lung Adenocarcinoma Cells Journal of Biological Chemistry. 276: 24901-24910. PMID 11335714 DOI: 10.1074/Jbc.M100314200  0.434
2001 Hannun YA, Luberto C, Argraves KM. Enzymes of sphingolipid metabolism: from modular to integrative signaling. Biochemistry. 40: 4893-903. PMID 11305904 DOI: 10.1021/Bi002836K  0.761
2001 Kroesen BJ, Pettus B, Luberto C, Busman M, Sietsma H, de Leij L, Hannun YA. Induction of apoptosis through B-cell receptor cross-linking occurs via de novo generated C16-ceramide and involves mitochondria. The Journal of Biological Chemistry. 276: 13606-14. PMID 11278517 DOI: 10.1074/Jbc.M009517200  0.425
2001 El Bawab S, Birbes H, Roddy P, Szulc ZM, Bielawska A, Hannun YA. Biochemical characterization of the reverse activity of rat brain ceramidase. A CoA-independent and fumonisin B1-insensitive ceramide synthase. The Journal of Biological Chemistry. 276: 16758-66. PMID 11278489 DOI: 10.1074/Jbc.M009331200  0.359
2001 Luberto C, Toffaletti DL, Wills EA, Tucker SC, Casadevall A, Perfect JR, Hannun YA, Del Poeta M. Roles for Inositol-phosphoryl ceramide synthase 1 (IPC1) in pathogenesis of C. neoformans Genes and Development. 15: 201-212. PMID 11157776 DOI: 10.1101/Gad.856001  0.401
2001 Smith ER, Merrill AH, Obeid LM, Hannun YA. Effects of sphingosine and other sphingolipids on protein kinase C. Methods in Enzymology. 312: 361-73. PMID 11070884 DOI: 10.1016/S0076-6879(00)12921-0  0.333
2001 Jenkins GM, Hannun YA. Role for de novo sphingoid base biosynthesis in the heat-induced transient cell cycle arrest of Saccharomyces cerevisiae. The Journal of Biological Chemistry. 276: 8574-81. PMID 11056159 DOI: 10.1074/Jbc.M007425200  0.674
2001 Sawai H, Okamoto Y, Luberto C, Mao C, Bielawska A, Domae N, Hannun YA. Identification of ISC1 (YER019w) as inositol phosphosphingolipid phospholipase C in Saccharomyces cerevisiae. The Journal of Biological Chemistry. 275: 39793-8. PMID 11006294 DOI: 10.1074/Jbc.M007721200  0.439
2000 Chalfant CE, Kishikawa K, Bielawska A, Hannun YA. Analysis of ceramide-activated protein phosphatases Methods in Enzymology. 312: 420-428. PMID 11070890 DOI: 10.1016/S0076-6879(00)12927-1  0.308
2000 Sawai H, Hannun YA. Ceramide and sphingomyelinases in the regulation of stress responses. Chemistry and Physics of Lipids. 102: 141-7. PMID 11001568 DOI: 10.1016/S0009-3084(99)00082-1  0.393
2000 Lee JY, Hannun YA, Obeid LM. Functional dichotomy of protein kinase C (PKC) in tumor necrosis factor-alpha (TNF-alpha ) signal transduction in L929 cells. Translocation and inactivation of PKC by TNF-alpha. The Journal of Biological Chemistry. 275: 29290-8. PMID 10887171 DOI: 10.1074/Jbc.M000170200  0.306
2000 Bae SS, Perry DK, Oh YS, Choi JH, Galadari SH, Ghayur T, Ryu SH, Hannun YA, Suh PG. Proteolytic cleavage of phospholipase C-γ1 during apoptosis in Molt-4 cells Faseb Journal. 14: 1083-1092. PMID 10834929 DOI: 10.1096/fasebj.14.9.1083  0.305
2000 Feng X, Becker KP, Stribling SD, Peters KG, Hannun YA. Regulation of receptor-mediated protein kinase C membrane trafficking by autophosphorylation. The Journal of Biological Chemistry. 275: 17024-34. PMID 10828076 DOI: 10.1074/Jbc.275.22.17024  0.389
2000 Luberto C, Yoo DS, Suidan HS, Bartoli GM, Hannun YA. Differential effects of sphingomyelin hydrolysis and resynthesis on the activation of NF-kappa B in normal and SV40-transformed human fibroblasts. The Journal of Biological Chemistry. 275: 14760-6. PMID 10799564 DOI: 10.1074/Jbc.275.19.14760  0.323
2000 Idriss HT, Hannun YA, Boulpaep E, Basavappa S. Regulation of volume-activated chloride channels by P-glycoprotein: Phosphorylation has the final say! Journal of Physiology. 524: 629-636. PMID 10790147 DOI: 10.1111/J.1469-7793.2000.00629.X  0.346
2000 Chung N, Jenkins G, Hannun YA, Heitman J, Obeid LM. Sphingolipids signal heat stress-induced ubiquitin-dependent proteolysis. The Journal of Biological Chemistry. 275: 17229-32. PMID 10764732 DOI: 10.1074/Jbc.C000229200  0.643
2000 Perry DK, Carton J, Shah AK, Meredith F, Uhlinger DJ, Hannun YA. Serine palmitoyltransferase regulates de novo ceramide generation during etoposide-induced apoptosis. The Journal of Biological Chemistry. 275: 9078-84. PMID 10722759 DOI: 10.1074/Jbc.275.12.9078  0.451
2000 Van Tiel CM, Luberto C, Snoek GT, Hannun YA, Wirtz KW. Rapid replenishment of sphingomyelin in the plasma membrane upon degradation by sphingomyelinase in NIH3T3 cells overexpressing the phosphatidylinositol transfer protein beta. The Biochemical Journal. 346: 537-43. PMID 10677376 DOI: 10.1042/0264-6021:3460537  0.372
2000 Hannun YA, Luberto C. Ceramide in the eukaryotic stress response. Trends in Cell Biology. 10: 73-80. PMID 10652518 DOI: 10.1016/S0962-8924(99)01694-3  0.37
2000 Sawai H, Domae N, Nagan N, Hannun YA. Function of the cloned putative neutral sphingomyelinase as lyso-platelet activating factor-phospholipase C. The Journal of Biological Chemistry. 274: 38131-9. PMID 10608884 DOI: 10.1074/Jbc.274.53.38131  0.414
1999 Liu B, Hannun YA. Sphingomyelinase assay using radiolabeled substrate. Methods in Enzymology. 311: 164-7. PMID 10563321 DOI: 10.1016/S0076-6879(00)11077-8  0.423
1999 Liu B, Hannun YA. Purification of rat brain membrane neutral sphingomyelinase. Methods in Enzymology. 311: 156-64. PMID 10563320 DOI: 10.1016/S0076-6879(00)11076-6  0.397
1999 El Bawab S, Bielawska A, Hannun YA. Purification and characterization of a membrane-bound nonlysosomal ceramidase from rat brain. The Journal of Biological Chemistry. 274: 27948-55. PMID 10488143 DOI: 10.1074/Jbc.274.39.27948  0.306
1999 Luberto C, Hannun YA. Sphingolipid metabolism in the regulation of bioactive molecules. Lipids. S5-11. PMID 10419081 DOI: 10.1007/Bf02562221  0.393
1999 Kishikawa K, Chalfant CE, Perry DK, Bielawska A, Hannun YA. Phosphatidic acid is a potent and selective inhibitor of protein phosphatase 1 and an inhibitor of ceramide-mediated responses Journal of Biological Chemistry. 274: 21335-21341. PMID 10409693 DOI: 10.1074/Jbc.274.30.21335  0.357
1999 Chalfant CE, Kishikawa K, Mumby MC, Kamibayashi C, Bielawska A, Hannun YA. Long chain ceramides activate protein phosphatase-1 and protein phosphatase-2A. Activation is stereospecific and regulated by phosphatidic acid. The Journal of Biological Chemistry. 274: 20313-7. PMID 10400653 DOI: 10.1074/Jbc.274.29.20313  0.407
1999 Kolesnick R, Hannun YA. Ceramide and apoptosis. Trends in Biochemical Sciences. 24: 224-5; author reply . PMID 10366847 DOI: 10.1016/S0968-0004(99)01408-5  0.302
1999 Zhang J, Reedy MC, Hannun YA, Obeid LM. Inhibition of caspases inhibits the release of apoptotic bodies: Bcl-2 inhibits the initiation of formation of apoptotic bodies in chemotherapeutic agent-induced apoptosis. The Journal of Cell Biology. 145: 99-108. PMID 10189371 DOI: 10.1083/Jcb.145.1.99  0.38
1999 Malik RK, Driscoll T, Hannun YA, Dbaibo G. Apoptosis Triggered by the Absence of an Integrin Signal: Role of the Sphingolipid Ceramide Pediatric Research. 45: 149A-149A. DOI: 10.1203/00006450-199904020-00886  0.336
1998 Perry DK, Hannun YA. The role of ceramide in cell signaling Biochimica Et Biophysica Acta - Lipids and Lipid Metabolism. 1436: 233-243. PMID 9838138 DOI: 10.1016/S0005-2760(98)00145-3  0.348
1998 Feng X, Hannun YA. An essential role for autophosphorylation in the dissociation of activated protein kinase C from the plasma membrane. The Journal of Biological Chemistry. 273: 26870-4. PMID 9756933 DOI: 10.1074/Jbc.273.41.26870  0.361
1998 Zhang J, Driscoll TA, Hannun YA, Obeid LM. Regulation of membrane release in apoptosis. The Biochemical Journal. 479-85. PMID 9716508 DOI: 10.1042/Bj3340479  0.389
1998 Dbaibo GS, Pushkareva MY, Rachid RA, Alter N, Smyth MJ, Obeid LM, Hannun YA. p53-dependent ceramide response to genotoxic stress. The Journal of Clinical Investigation. 102: 329-39. PMID 9664074 DOI: 10.1172/Jci1180  0.379
1998 Luberto C, Hannun YA. Sphingomyelin synthase, a potential regulator of intracellular levels of ceramide and diacylglycerol during SV40 transformation. Does sphingomyelin synthase account for the putative phosphatidylcholine-specific phospholipase C? The Journal of Biological Chemistry. 273: 14550-9. PMID 9603970 DOI: 10.1074/Jbc.273.23.14550  0.42
1998 Liu B, Andrieu-Abadie N, Levade T, Zhang P, Obeid LM, Hannun YA. Glutathione regulation of neutral sphingomyelinase in tumor necrosis factor-alpha-induced cell death. The Journal of Biological Chemistry. 273: 11313-20. PMID 9556624 DOI: 10.1074/Jbc.273.18.11313  0.456
1998 Hannun YA. Sphingolipid second messengers: tumor suppressor lipids. Advances in Experimental Medicine and Biology. 305-12. PMID 9547572 DOI: 10.1007/978-1-4615-5325-0_43  0.384
1998 Malik RK, Dbaibo G, Hannun YA, Parsons JT. The Integrin-Mediated Suppression of Apoptosis Correlates with Suppression of Ceramide Generation † 780 Pediatric Research. 43: 135-135. DOI: 10.1203/00006450-199804001-00801  0.325
1998 Laethem RM, Hannun YA, Jayadev S, Sexton CJ, Strum JC, Sundseth R, Smith GK. Increases in Neutral, Mg2+-Dependent and Acidic, Mg2+-Independent Sphingomyelinase Activities Precede Commitment to Apoptosis and Are Not a Consequence of Caspase 3–Like Activity in Molt-4 Cells in Response to Thymidylate Synthase Inhibition by GW1843 Blood. 91: 4350-4360. DOI: 10.1182/Blood.V91.11.4350.411K27_4350_4360  0.446
1997 Perry DK, Smyth MJ, Wang HG, Reed JC, Duriez P, Poirier GG, Obeid LM, Hannun YA. Bcl-2 acts upstream of the PARP protease and prevents its activation. Cell Death and Differentiation. 4: 29-33. PMID 16465207 DOI: 10.1038/Sj.Cdd.4400200  0.427
1997 Liu B, Obeid LM, Hannun YA. Sphingomyelinases in cell regulation. Seminars in Cell & Developmental Biology. 8: 311-322. PMID 10024495 DOI: 10.1006/Scdb.1997.0153  0.45
1997 Jenkins GM, Richards A, Wahl T, Mao C, Obeid L, Hannun Y. Involvement of yeast sphingolipids in the heat stress response of Saccharomyces cerevisiae Journal of Biological Chemistry. 272: 32566-32572. PMID 9405471 DOI: 10.1074/Jbc.272.51.32566  0.623
1997 Mao C, Wadleigh M, Jenkins GM, Hannun YA, Obeid LM. Identification and characterization of Saccharomyces cerevisiae dihydrosphingosine-1-phosphate phosphatase. The Journal of Biological Chemistry. 272: 28690-4. PMID 9353337 DOI: 10.1074/Jbc.272.45.28690  0.629
1997 Saba JD, Nara F, Bielawska A, Garrett S, Hannun YA. The BST1 gene of Saccharomyces cerevisiae is the sphingosine-1-phosphate lyase. The Journal of Biological Chemistry. 272: 26087-90. PMID 9334171 DOI: 10.1074/Jbc.272.42.26087  0.395
1997 Hannun YA, Obeid LM. Mechanisms of ceramide-mediated apoptosis. Advances in Experimental Medicine and Biology. 407: 145-9. PMID 9321945 DOI: 10.1007/978-1-4899-1813-0_22  0.433
1997 Lee TG, Park JB, Lee SD, Hong S, Kim JH, Kim Y, Yi KS, Bae S, Hannun YA, Obeid LM, Suh PG, Ryu SH. Phorbol myristate acetate-dependent association of protein kinase C alpha with phospholipase D1 in intact cells. Biochimica Et Biophysica Acta. 1347: 199-204. PMID 9295164 DOI: 10.1016/S0005-2760(97)00083-0  0.39
1997 Wieder T, Geilen CC, Kolter T, Sadeghlar F, Sandhoff K, Brossmer R, Ihrig P, Perry D, Orfanos CE, Hannun YA. Bcl-2 antagonizes apoptotic cell death induced by two new ceramide analogues. Febs Letters. 411: 260-4. PMID 9271217 DOI: 10.1016/S0014-5793(97)00717-5  0.406
1997 Perry DK, Smyth MJ, Stennicke HR, Salvesen GS, Duriez P, Poirier GG, Hannun YA. Zinc is a potent inhibitor of the apoptotic protease, caspase-3. A novel target for zinc in the inhibition of apoptosis. The Journal of Biological Chemistry. 272: 18530-3. PMID 9228015 DOI: 10.1074/Jbc.272.30.18530  0.347
1997 Jayadev S, Hayter HL, Andrieu N, Gamard CJ, Liu B, Balu R, Hayakawa M, Ito F, Hannun YA. Phospholipase A2 is necessary for tumor necrosis factor alpha-induced ceramide generation in L929 cells. The Journal of Biological Chemistry. 272: 17196-203. PMID 9202042 DOI: 10.1074/Jbc.272.27.17196  0.786
1997 Gamard CJ, Dbaibo GS, Liu B, Obeid LM, Hannun YA. Selective involvement of ceramide in cytokine-induced apoptosis. Ceramide inhibits phorbol ester activation of nuclear factor kappaB. The Journal of Biological Chemistry. 272: 16474-81. PMID 9195956 DOI: 10.1074/Jbc.272.26.16474  0.392
1997 Lai TS, Bielawska A, Peoples KA, Hannun YA, Greenberg CS. Sphingosylphosphocholine reduces the calcium ion requirement for activating tissue transglutaminase Journal of Biological Chemistry. 272: 16295-16300. PMID 9195933 DOI: 10.1074/Jbc.272.26.16295  0.317
1997 Liu B, Hannun YA. Inhibition of the neutral magnesium-dependent sphingomyelinase by glutathione. The Journal of Biological Chemistry. 272: 16281-7. PMID 9195931 DOI: 10.1074/Jbc.272.26.16281  0.415
1997 Wang Y, Roman R, Schlenker T, Hannun YA, Raymond J, Fitz JG. Cytosolic Ca2+ and protein kinase Calpha couple cellular metabolism to membrane K+ permeability in a human biliary cell line. The Journal of Clinical Investigation. 99: 2890-7. PMID 9185512 DOI: 10.1172/Jci119483  0.343
1997 Zhang P, Liu B, Jenkins GM, Hannun YA, Obeid LM. Expression of neutral sphingomyelinase identifies a distinct pool of sphingomyelin involved in apoptosis. The Journal of Biological Chemistry. 272: 9609-12. PMID 9092485 DOI: 10.1074/Jbc.272.15.9609  0.697
1997 Dbaibo GS, Perry DK, Gamard CJ, Platt R, Poirier GG, Obeid LM, Hannun YA. Cytokine response modifier A (CrmA) inhibits ceramide formation in response to tumor necrosis factor (TNF)-alpha: CrmA and Bcl-2 target distinct components in the apoptotic pathway. The Journal of Experimental Medicine. 185: 481-90. PMID 9053448 DOI: 10.1084/Jem.185.3.481  0.385
1997 Hannun YA. Functions of ceramide in coordinating cellular responses to stress. Science (New York, N.Y.). 274: 1855-9. PMID 8943189 DOI: 10.1126/Science.274.5294.1855  0.472
1997 Hannun YA, Jayadev S. The sphingomyelin cycle: The flip side of the lipid signaling paradigm Advances in Lipobiology. 2: 143-166. DOI: 10.1016/S1874-5245(97)80008-0  0.404
1996 Perry DK, Obeid LM, Hannun YA. Ceramide and the regulation of apoptosis and the stress response. Trends in Cardiovascular Medicine. 6: 158-62. PMID 21232290 DOI: 10.1016/1050-1738(96)00044-8  0.398
1996 Jideama NM, Noland TA, Raynor RL, Blobe GC, Fabbro D, Kazanietz MG, Blumberg PM, Hannun YA, Kuo JF. Phosphorylation specificities of protein kinase C isozymes for bovine cardiac troponin I and troponin T and sites within these proteins and regulation of myofilament properties. The Journal of Biological Chemistry. 271: 23277-83. PMID 8798526 DOI: 10.1074/Jbc.271.38.23277  0.306
1996 Wang Y, Sostman A, Roman R, Stribling S, Vigna S, Hannun Y, Raymond J, Fitz JG. Metabolic stress opens K+ channels in hepatoma cells through a Ca2+- and protein kinase calpha-dependent mechanism. The Journal of Biological Chemistry. 271: 18107-13. PMID 8663472 DOI: 10.1074/Jbc.271.30.18107  0.376
1996 Lee JY, Hannun YA, Obeid LM. Ceramide inactivates cellular protein kinase Calpha. The Journal of Biological Chemistry. 271: 13169-74. PMID 8662781 DOI: 10.1074/Jbc.271.22.13169  0.45
1996 Saba JD, Obeid LM, Hannun YA. Ceramide: an intracellular mediator of apoptosis and growth suppression. Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences. 351: 233-40; discussion 2. PMID 8650271 DOI: 10.1098/Rstb.1996.0021  0.439
1996 Bielawska A, Greenberg MS, Perry D, Jayadev S, Shayman JA, McKay C, Hannun YA. (1S,2R)-D-erythro-2-(N-myristoylamino)-1-phenyl-1-propanol as an inhibitor of ceramidase Journal of Biological Chemistry. 271: 12646-12654. PMID 8647877 DOI: 10.1074/Jbc.271.21.12646  0.333
1996 Smyth MJ, Perry DK, Zhang J, Poirier GG, Hannun YA, Obeid LM. prICE: a downstream target for ceramide-induced apoptosis and for the inhibitory action of Bcl-2. The Biochemical Journal. 316: 25-8. PMID 8645213 DOI: 10.1042/Bj3160025  0.395
1996 Zhang J, Alter N, Reed JC, Borner C, Obeid LM, Hannun YA. Bcl-2 interrupts the ceramide-mediated pathway of cell death. Proceedings of the National Academy of Sciences of the United States of America. 93: 5325-8. PMID 8643573 DOI: 10.1073/Pnas.93.11.5325  0.447
1996 Hayakawa M, Jayadev S, Tsujimoto M, Hannun YA, Ito F. Role of ceramide in stimulation of the transcription of cytosolic phospholipase A2 and cyclooxygenase 2. Biochemical and Biophysical Research Communications. 220: 681-6. PMID 8607825 DOI: 10.1006/Bbrc.1996.0464  0.426
1995 Dbaibo GS, Pushkareva MY, Jayadev S, Schwarz JK, Horowitz JM, Obeid LM, Hannun YA. Retinoblastoma gene product as a downstream target for a ceramide-dependent pathway of growth arrest Proceedings of the National Academy of Sciences of the United States of America. 92: 1347-1351. PMID 7877980 DOI: 10.1073/Pnas.92.5.1347  0.436
1995 Pushkareva M, Chao R, Bielawska A, Merrill AH, Crane HM, Lagu B, Liotta D, Hannun YA. Stereoselectivity of induction of the retinoblastoma gene product (pRb) dephosphorylation by D-erythro-sphingosine supports a role for pRb in growth suppression by sphingosine. Biochemistry. 34: 1885-92. PMID 7849048 DOI: 10.1021/Bi00006A009  0.403
1995 Jayadev S, Liu B, Bielawska AE, Lee JY, Nazaire F, Obeid LM, Hannun YA. Role for ceramide in cell cycle arrest. The Journal of Biological Chemistry. 270: 2047-52. PMID 7836432 DOI: 10.1074/Jbc.270.5.2047  0.451
1995 Blobe GC, Khan WA, Hannun YA. Protein kinase C: cellular target of the second messenger arachidonic acid? Prostaglandins, Leukotrienes, and Essential Fatty Acids. 52: 129-35. PMID 7784448 DOI: 10.1016/0952-3278(95)90011-X  0.387
1995 Blobe GC, Obeid LM, Hannun YA. Regulation of protein kinase C and role in cancer biology. Cancer Metastasis Reviews. 13: 411-31. PMID 7712599 DOI: 10.1007/Bf00666107  0.418
1995 Hannun YA, Obeid LM. Ceramide: an intracellular signal for apoptosis. Trends in Biochemical Sciences. 20: 73-7. PMID 7701566 DOI: 10.1016/S0968-0004(00)88961-6  0.428
1995 Obeid LM, Hannun YA. Ceramide: a stress signal and mediator of growth suppression and apoptosis. Journal of Cellular Biochemistry. 58: 191-8. PMID 7673327 DOI: 10.1002/Jcb.240580208  0.427
1995 Dobrowsky RT, Jenkins GM, Hannun YA. Neurotrophins induce sphingomyelin hydrolysis. Modulation by co-expression of p75NTR with Trk receptors. The Journal of Biological Chemistry. 270: 22135-42. PMID 7673191 DOI: 10.1074/Jbc.270.38.22135  0.665
1995 Khan WA, Blobe GC, Hannun YA. Arachidonic acid and free fatty acids as second messengers and the role of protein kinase C. Cellular Signalling. 7: 171-84. PMID 7662506 DOI: 10.1016/0898-6568(94)00089-T  0.425
1995 Pushkareva M, Obeid LM, Hannun YA. Ceramide: an endogenous regulator of apoptosis and growth suppression. Immunology Today. 16: 294-7. PMID 7662099 DOI: 10.1016/0167-5699(95)80184-7  0.432
1995 Dbaibo GS, Wolff RA, Obeid LM, Hannun YA. Activation of a retinoblastoma-protein-dependent pathway by sphingosine. The Biochemical Journal. 453-9. PMID 7654183 DOI: 10.1042/Bj3100453  0.422
1995 Liu B, Khan WA, Hannun YA, Timar J, Taylor JD, Lundy S, Butovich I, Honn KV. 12(S)-hydroxyeicosatetraenoic acid and 13(S)-hydroxyoctadecadienoic acid regulation of protein kinase C-alpha in melanoma cells: role of receptor-mediated hydrolysis of inositol phospholipids. Proceedings of the National Academy of Sciences of the United States of America. 92: 9323-7. PMID 7568126 DOI: 10.1073/Pnas.92.20.9323  0.374
1995 Westwick JK, Bielawska AE, Dbaibo G, Hannun YA, Brenner DA. Ceramide activates the stress-activated protein kinases. The Journal of Biological Chemistry. 270: 22689-92. PMID 7559390 DOI: 10.1074/Jbc.270.39.22689  0.378
1995 Tepper CG, Jayadev S, Liu B, Bielawska A, Wolff R, Yonehara S, Hannun YA, Seldin MF. Role for ceramide as an endogenous mediator of Fas-induced cytotoxicity. Proceedings of the National Academy of Sciences of the United States of America. 92: 8443-7. PMID 7545303 DOI: 10.1073/Pnas.92.18.8443  0.457
1994 Hannun YA, Linardic CM. Sphingolipid breakdown products: anti-proliferative and tumor-suppressor lipids. Biochimica Et Biophysica Acta. 1154: 223-36. PMID 8280742 DOI: 10.1016/0304-4157(93)90001-5  0.463
1994 Hannun YA. Modulation of cytosolic protein phosphorylation by sphingosylphosphorylcholine. Biochimica Et Biophysica Acta. 1221: 54-60. PMID 8130276 DOI: 10.1016/0167-4889(94)90215-1  0.346
1994 Dobrowsky RT, Werner MH, Castellino AM, Chao MV, Hannun YA. Activation of the sphingomyelin cycle through the low-affinity neurotrophin receptor. Science (New York, N.Y.). 265: 1596-9. PMID 8079174 DOI: 10.1126/Science.8079174  0.347
1994 Liu B, Maher RJ, Hannun YA, Porter AT, Honn KV. 12(S)-hete enhancement of prostate tumor cell invasion: Selective role of PKCα Journal of the National Cancer Institute. 86: 1145-1151. PMID 7518003 DOI: 10.1093/Jnci/86.15.1145  0.369
1994 Okazaki T, Domae N, Bell R, Hannun Y. Ceramide, a Sphingolipid Second Messenger. Trends in Glycoscience and Glycotechnology. 6: 278-285. DOI: 10.4052/Tigg.6.278  0.455
1993 Obeid LM, Linardic CM, Karolak LA, Hannun YA. Programmed cell death induced by ceramide. Science (New York, N.Y.). 259: 1769-71. PMID 8456305 DOI: 10.1126/Science.8456305  0.43
1993 Tuominen RK, Werner MH, Ye H, McMillian MK, Hudson PM, Hannun YA, Hong JS. Biphasic generation of diacylglycerol by angiotensin and phorbol ester in bovine adrenal chromaffin cells. Biochemical and Biophysical Research Communications. 190: 181-5. PMID 8380691 DOI: 10.1006/Bbrc.1993.1028  0.334
1993 Bielawska A, Menaldiv D, Liotta D, Hannun YA. Regulation of sphingosine-activated protein kinases: selectivity of activation by sphingoid bases and inhibition by non-esterified fatty acids. The Biochemical Journal. 699-703. PMID 8379926 DOI: 10.1042/Bj2940699  0.389
1992 Khan W, el Touny S, Hannun YA. Arachidonic and cis-unsaturated fatty acids induce selective platelet substrate phosphorylation through activation of cytosolic protein kinase C. Febs Letters. 292: 98-102. PMID 1959637 DOI: 10.1016/0014-5793(91)80843-R  0.37
1992 Bielawska A, Linardic CM, Hannun YA. Modulation of cell growth and differentiation by ceramide. Febs Letters. 307: 211-4. PMID 1644175 DOI: 10.1016/0014-5793(92)80769-D  0.41
1992 Bell R, Burns D, Okazaki T, Hannun Y. Network of signal transduction pathways involving lipids: protein kinase C-dependent and -independent pathways. Advances in Experimental Medicine and Biology. 318: 275-84. PMID 1636498 DOI: 10.1007/978-1-4615-3426-6_24  0.609
1992 Werner MH, Bielawska AE, Hannun YA. Multiphasic generation of diacylglycerol in thrombin-activated human platelets. The Biochemical Journal. 815-20. PMID 1554365 DOI: 10.1042/Bj2820815  0.304
1991 Hannun YA, Merrill AH, Bell RM. Use of sphingosine as inhibitor of protein kinase C Methods in Enzymology. 201: 316-328. PMID 1943771 DOI: 10.1016/0076-6879(91)01028-Z  0.6
1991 Dennis EA, Rhee SG, Billah MM, Hannun YA. Role of phospholipase in generating lipid second messengers in signal transduction. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. 5: 2068-77. PMID 1901288 DOI: 10.1096/Fasebj.5.7.1901288  0.391
1991 Khan WA, Mascarella SW, Lewin AH, Wyrick CD, Carroll FI, Hannun YA. Use of D-erythro-sphingosine as a pharmacological inhibitor of protein kinase C in human platelets. The Biochemical Journal. 278: 387-92. PMID 1898331 DOI: 10.1042/Bj2780387  0.356
1991 Werner M, Hannun Y. Delayed accumulation of diacylglycerol in platelets as a mechanism for regulation of onset of aggregation and secretion Blood. 78: 435-444. DOI: 10.1182/Blood.V78.2.435.435  0.303
1990 Sane DC, Bielawska A, Greenberg CS, Hannun YA. Cyclic GMP analogs inhibit gamma thrombin-induced arachidonic acid release in human platelets. Biochemical and Biophysical Research Communications. 165: 708-14. PMID 2557018 DOI: 10.1016/S0006-291X(89)80024-5  0.311
1990 Khan WA, Dobrowsky R, el Touny S, Hannun YA. Protein kinase C and platelet inhibition by D-erythro-sphingosine: comparison with N,N-dimethylsphingosine and commercial preparation. Biochemical and Biophysical Research Communications. 172: 683-91. PMID 2241961 DOI: 10.1016/0006-291X(90)90728-6  0.364
1989 Merrill AH, Nimkar S, Menaldino D, Hannun YA, Loomis C, Bell RM, Tyagi SR, Lambeth JD, Stevens VL, Hunter R, Liotta DC. Structural requirements for long-chain (sphingoid) base inhibition of protein kinase C in vitro and for the cellular effects of these compounds Biochemistry. 28: 3138-3145. PMID 2742830 DOI: 10.1021/Bi00434A004  0.587
1989 Hannun YA, Bell RM. Regulation of protein kinase C by sphingosine and lysosphingolipids. Clinica Chimica Acta; International Journal of Clinical Chemistry. 185: 333-45. PMID 2695275 DOI: 10.1016/0009-8981(89)90224-6  0.614
1989 Hannun YA, Bell RM. Functions of sphingolipids and sphingolipid breakdown products in cellular regulation. Science (New York, N.Y.). 243: 500-7. PMID 2643164 DOI: 10.1126/Science.2643164  0.616
1989 Hannun YA. Response:Sphingomyelin synthase and PKC activation Science. 246: 1050-1050. DOI: 10.1126/Science.246.4933.1050-A  0.307
1988 Bell RM, Loomis CR, Hannun YA. Protein kinase C regulation by sphingosine/lysosphingolipids. Cold Spring Harbor Symposia On Quantitative Biology. 53: 103-10. PMID 3076075 DOI: 10.1101/Sqb.1988.053.01.016  0.551
1987 Hannun YA, Bell RM. Mixed micellar assay for phorbol ester binding. Methods in Enzymology. 141: 287-93. PMID 3298964 DOI: 10.1016/0076-6879(87)41076-8  0.539
1987 Hannun YA, Bell RM. Lysosphingolipids inhibit protein kinase C: implications for the sphingolipidoses. Science (New York, N.Y.). 235: 670-4. PMID 3101176 DOI: 10.1126/Science.3101176  0.59
1986 Bell RM, Hannun Y, Loomis C. Mixed micelle assay of protein kinase C. Methods in Enzymology. 124: 353-9. PMID 3520216 DOI: 10.1016/0076-6879(86)24027-6  0.326
1986 Ganong BR, Loomis CR, Hannun YA, Bell RM. Specificity and mechanism of protein kinase C activation by sn-1,2-diacylglycerols. Proceedings of the National Academy of Sciences of the United States of America. 83: 1184-8. PMID 3456578 DOI: 10.1073/Pnas.83.5.1184  0.57
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