Rafi Ahmed - Publications

Emory University, Atlanta, GA 
Immunology, Microbiology

194 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2019 Moore JR, Ahmed H, McGuire D, Akondy R, Ahmed R, Antia R. Dependence of CD8 T Cell Response upon Antigen Load During Primary Infection : Analysis of Data from Yellow Fever Vaccination. Bulletin of Mathematical Biology. PMID 31165405 DOI: 10.1007/s11538-019-00618-9  0.44
2019 Davis CW, Jackson KJL, McElroy AK, Halfmann P, Huang J, Chennareddy C, Piper AE, Leung Y, Albariño CG, Crozier I, Ellebedy AH, Sidney J, Sette A, Yu T, Nielsen SCA, ... ... Ahmed R, et al. Longitudinal Analysis of the Human B Cell Response to Ebola Virus Infection. Cell. PMID 31104840 DOI: 10.1016/j.cell.2019.04.036  0.44
2019 Gunisetty S, Nayak K, Chandra Rai R, Chawla Y, Elluri SR, Aggarwal C, Maheshwari D, Panda H, Ansari NA, Singh P, Kaur M, Dixit K, Sharma P, Bhatnagar P, Priyamvada L, ... ... Ahmed R, et al. Analysis of dengue specific memory B cells, neutralizing antibodies and binding antibodies in healthy adults from India. International Journal of Infectious Diseases : Ijid : Official Publication of the International Society For Infectious Diseases. PMID 30658170 DOI: 10.1016/j.ijid.2019.01.018  0.44
2018 Mylvaganam GH, Chea LS, Tharp GK, Hicks S, Velu V, Iyer SS, Deleage C, Estes JD, Bosinger SE, Freeman GJ, Ahmed R, Amara RR. Combination anti-PD-1 and antiretroviral therapy provides therapeutic benefit against SIV. Jci Insight. 3. PMID 30232277 DOI: 10.1172/jci.insight.122940  0.44
2018 Ahn E, Araki K, Hashimoto M, Li W, Riley JL, Cheung J, Sharpe AH, Freeman GJ, Irving BA, Ahmed R. Role of PD-1 during effector CD8 T cell differentiation. Proceedings of the National Academy of Sciences of the United States of America. PMID 29654146 DOI: 10.1073/pnas.1718217115  0.32
2018 Ramasamy V, Arora U, Shukla R, Poddar A, Shanmugam RK, White LJ, Mattocks MM, Raut R, Perween A, Tyagi P, de Silva AM, Bhaumik SK, Kaja MK, Villinger F, Ahmed R, et al. A tetravalent virus-like particle vaccine designed to display domain III of dengue envelope proteins induces multi-serotype neutralizing antibodies in mice and macaques which confer protection against antibody dependent enhancement in AG129 mice. Plos Neglected Tropical Diseases. 12: e0006191. PMID 29309412 DOI: 10.1371/journal.pntd.0006191  0.44
2017 Akondy RS, Fitch M, Edupuganti S, Yang S, Kissick HT, Li KW, Youngblood BA, Abdelsamed HA, McGuire DJ, Cohen KW, Alexe G, Nagar S, McCausland MM, Gupta S, Tata P, ... ... Ahmed R, et al. Origin and differentiation of human memory CD8 T cells after vaccination. Nature. PMID 29236685 DOI: 10.1038/nature24633  0.4
2017 Youngblood B, Hale JS, Kissick HT, Ahn E, Xu X, Wieland A, Araki K, West EE, Ghoneim HE, Fan Y, Dogra P, Davis CW, Konieczny BT, Antia R, Cheng X, ... Ahmed R, et al. Effector CD8 T cells dedifferentiate into long-lived memory cells. Nature. PMID 29236683 DOI: 10.1038/nature25144  0.44
2017 Moore J, Ahmed H, Jia J, Akondy R, Ahmed R, Antia R. What Controls the Acute Viral Infection Following Yellow Fever Vaccination? Bulletin of Mathematical Biology. PMID 29110131 DOI: 10.1007/s11538-017-0365-3  0.44
2017 Araki K, Morita M, Bederman AG, Konieczny BT, Kissick HT, Sonenberg N, Ahmed R. Translation is actively regulated during the differentiation of CD8(+) effector T cells. Nature Immunology. PMID 28714979 DOI: 10.1038/ni.3795  0.36
2017 Li S, Sullivan NL, Rouphael N, Yu T, Banton S, Maddur MS, McCausland M, Chiu C, Canniff J, Dubey S, Liu K, Tran V, Hagan T, Duraisingham S, Wieland A, ... ... Ahmed R, et al. Metabolic Phenotypes of Response to Vaccination in Humans. Cell. PMID 28502771 DOI: 10.1016/j.cell.2017.04.026  0.44
2017 Kamphorst AO, Wieland A, Nasti T, Yang S, Zhang R, Barber DL, Konieczny BT, Daugherty CZ, Koenig L, Yu K, Sica GL, Sharpe AH, Freeman GJ, Blazar BR, Turka LA, ... ... Ahmed R, et al. Rescue of exhausted CD8 T cells by PD-1-targeted therapies is CD28-dependent. Science (New York, N.Y.). PMID 28280249 DOI: 10.1126/science.aaf0683  0.68
2017 Kazmin D, Nakaya HI, Lee EK, Johnson MJ, van der Most R, van den Berg RA, Ballou WR, Jongert E, Wille-Reece U, Ockenhouse C, Aderem A, Zak DE, Sadoff J, Hendriks J, Wrammert J, ... Ahmed R, et al. Systems analysis of protective immune responses to RTS,S malaria vaccination in humans. Proceedings of the National Academy of Sciences of the United States of America. PMID 28193898 DOI: 10.1073/pnas.1621489114  0.44
2016 Lee J, Hashimoto M, Im SJ, Araki K, Jin HT, Davis CW, Konieczny BT, Spies GA, McElrath MJ, Ahmed R. Adenovirus serotype 5 vaccination results in suboptimal CD4 T helper 1 responses in mice. Journal of Virology. PMID 28003483 DOI: 10.1128/JVI.01132-16  0.36
2016 Ye L, Lee J, Xu L, Mohammed AU, Li W, Hale JS, Tan WG, Wu T, Davis CW, Ahmed R, Araki K. mTOR promotes anti-viral humoral immunity by differentially regulating CD4 helper T cell and B cell responses. Journal of Virology. PMID 27974559 DOI: 10.1128/JVI.01653-16  0.44
2016 Havenar-Daughton C, Carnathan DG, Torrents de la Peña A, Pauthner M, Briney B, Reiss SM, Wood JS, Kaushik K, van Gils MJ, Rosales SL, van der Woude P, Locci M, Le KM, de Taeye SW, Sok D, ... ... Ahmed R, et al. Direct Probing of Germinal Center Responses Reveals Immunological Features and Bottlenecks for Neutralizing Antibody Responses to HIV Env Trimer. Cell Reports. 17: 2195-2209. PMID 27880897 DOI: 10.1016/j.celrep.2016.10.085  0.4
2016 Owonikoko TK, Kumar M, Yang S, Kamphorst AO, Pillai RN, Akondy R, Nautiyal V, Chatwal MS, Book WM, Sahu A, Sica GL, Ahmed R, Ramalingam SS. Cardiac allograft rejection as a complication of PD-1 checkpoint blockade for cancer immunotherapy: a case report. Cancer Immunology, Immunotherapy : Cii. PMID 27771741 DOI: 10.1007/s00262-016-1918-2  0.8
2016 Chandele A, Sewatanon J, Gunisetty S, Singla M, Onlamoon N, Akondy RS, Kissick HT, Nayak K, Reddy ES, Kalam H, Kumar D, Verma A, Panda H, Wang S, Angkasekwinai N, ... ... Ahmed R, et al. Characterization of human CD8 T cell responses in dengue virus infected patients from India. Journal of Virology. PMID 27707928 DOI: 10.1128/JVI.01424-16  0.44
2016 Ellebedy AH, Jackson KJ, Kissick HT, Nakaya HI, Davis CW, Roskin KM, McElroy AK, Oshansky CM, Elbein R, Thomas S, Lyon GM, Spiropoulou CF, Mehta AK, Thomas PG, Boyd SD, ... Ahmed R, et al. Defining antigen-specific plasmablast and memory B cell subsets in human blood after viral infection or vaccination. Nature Immunology. PMID 27525369 DOI: 10.1038/ni.3533  0.8
2016 Im SJ, Hashimoto M, Gerner MY, Lee J, Kissick HT, Burger MC, Shan Q, Hale JS, Lee J, Nasti TH, Sharpe AH, Freeman GJ, Germain RN, Nakaya HI, Xue HH, ... Ahmed R, et al. Defining CD8(+) T cells that provide the proliferative burst after PD-1 therapy. Nature. PMID 27501248 DOI: 10.1038/nature19330  0.32
2016 Ahmed R, Fraser NW, Ghiasi H, Jones C. Remembrance of Professor Steven Wechsler (1948-2016). Journal of Neurovirology. PMID 27491501 DOI: 10.1007/s13365-016-0469-9  0.8
2016 Ahn E, Youngblood B, Lee J, Lee J, Sarkar S, Ahmed R. Demethylation of the PD-1 promoter is imprinted during the effector phase of CD8 T cell exhaustion. Journal of Virology. PMID 27466420 DOI: 10.1128/JVI.00798-16  0.36
2016 Zarnitsyna VI, Lavine J, Ellebedy A, Ahmed R, Antia R. Multi-epitope Models Explain How Pre-existing Antibodies Affect the Generation of Broadly Protective Responses to Influenza. Plos Pathogens. 12: e1005692. PMID 27336297 DOI: 10.1371/journal.ppat.1005692  0.44
2016 Kang E, Wang X, Tippner-Hedges R, Ma H, Folmes CD, Gutierrez NM, Lee Y, Van Dyken C, Ahmed R, Li Y, Koski A, Hayama T, Luo S, Harding CO, Amato P, et al. Age-Related Accumulation of Somatic Mitochondrial DNA Mutations in Adult-Derived Human iPSCs. Cell Stem Cell. 18: 625-636. PMID 27151456 DOI: 10.1016/j.stem.2016.02.005  0.44
2016 Havenar-Daughton C, Lindqvist M, Heit A, Wu JE, Reiss SM, Kendric K, Bélanger S, Kasturi SP, Landais E, Akondy RS, McGuire HM, Bothwell M, Vagefi PA, Scully E, ... ... Ahmed R, et al. CXCL13 is a plasma biomarker of germinal center activity. Proceedings of the National Academy of Sciences of the United States of America. PMID 26908875 DOI: 10.1073/pnas.1520112113  0.4
2015 Nakaya HI, Hagan T, Duraisingham SS, Lee EK, Kwissa M, Rouphael N, Frasca D, Gersten M, Mehta AK, Gaujoux R, Li GM, Gupta S, Ahmed R, Mulligan MJ, Shen-Orr S, et al. Systems Analysis of Immunity to Influenza Vaccination across Multiple Years and in Diverse Populations Reveals Shared Molecular Signatures. Immunity. 43: 1186-98. PMID 26682988 DOI: 10.1016/j.immuni.2015.11.012  0.8
2015 Andrews SF, Huang Y, Kaur K, Popova LI, Ho IY, Pauli NT, Henry Dunand CJ, Taylor WM, Lim S, Huang M, Qu X, Lee JH, Salgado-Ferrer M, Krammer F, Palese P, ... ... Ahmed R, et al. Immune history profoundly affects broadly protective B cell responses to influenza. Science Translational Medicine. 7: 316ra192. PMID 26631631 DOI: 10.1126/scitranslmed.aad0522  0.8
2015 Ray JP, Staron MM, Shyer JA, Ho PC, Marshall HD, Gray SM, Laidlaw BJ, Araki K, Ahmed R, Kaech SM, Craft J. The Interleukin-2-mTORc1 Kinase Axis Defines the Signaling, Differentiation, and Metabolism of T Helper 1 and Follicular B Helper T Cells. Immunity. PMID 26410627 DOI: 10.1016/j.immuni.2015.08.017  0.8
2015 Wu T, Wieland A, Lee J, Hale JS, Han JH, Xu X, Ahmed R. Cutting Edge: miR-17-92 Is Required for Both CD4 Th1 and T Follicular Helper Cell Responses during Viral Infection. Journal of Immunology (Baltimore, Md. : 1950). PMID 26276869 DOI: 10.4049/jimmunol.1500317  0.8
2015 Mascola JR, Ahmed R. Editorial overview: Vaccines: Vaccines for cancer and infectious diseases. Current Opinion in Immunology. 35: v-vii. PMID 26275318 DOI: 10.1016/j.coi.2015.07.009  0.8
2015 Zarnitsyna VI, Ellebedy AH, Davis C, Jacob J, Ahmed R, Antia R. Masking of antigenic epitopes by antibodies shapes the humoral immune response to influenza. Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences. 370. PMID 26194761 DOI: 10.1098/rstb.2014.0248  0.8
2015 Ma H, Folmes CD, Wu J, Morey R, Mora-Castilla S, Ocampo A, Ma L, Poulton J, Wang X, Ahmed R, Kang E, Lee Y, Hayama T, Li Y, Van Dyken C, et al. Metabolic rescue in pluripotent cells from patients with mtDNA disease. Nature. PMID 26176921 DOI: 10.1038/nature14546  0.44
2015 Youngblood B, Hale JS, Ahmed R. Memory CD8 T cell transcriptional plasticity. F1000prime Reports. 7: 38. PMID 26097712 DOI: 10.12703/P7-38  0.8
2015 Bally AP, Lu P, Tang Y, Austin JW, Scharer CD, Ahmed R, Boss JM. NF-κB regulates PD-1 expression in macrophages. Journal of Immunology (Baltimore, Md. : 1950). 194: 4545-54. PMID 25810391 DOI: 10.4049/jimmunol.1402550  0.8
2015 McElroy AK, Akondy RS, Davis CW, Ellebedy AH, Mehta AK, Kraft CS, Lyon GM, Ribner BS, Varkey J, Sidney J, Sette A, Campbell S, Ströher U, Damon I, Nichol ST, ... ... Ahmed R, et al. Human Ebola virus infection results in substantial immune activation. Proceedings of the National Academy of Sciences of the United States of America. 112: 4719-24. PMID 25775592 DOI: 10.1073/pnas.1502619112  0.8
2015 Akondy RS, Johnson PL, Nakaya HI, Edupuganti S, Mulligan MJ, Lawson B, Miller JD, Pulendran B, Antia R, Ahmed R. Initial viral load determines the magnitude of the human CD8 T cell response to yellow fever vaccination. Proceedings of the National Academy of Sciences of the United States of America. 112: 3050-5. PMID 25713354 DOI: 10.1073/pnas.1500475112  0.8
2015 Hale JS, Ahmed R. Memory T follicular helper CD4 T cells. Frontiers in Immunology. 6: 16. PMID 25699040 DOI: 10.3389/fimmu.2015.00016  0.8
2015 Wieland A, Shashidharamurthy R, Kamphorst AO, Han JH, Aubert RD, Choudhury BP, Stowell SR, Lee J, Punkosdy GA, Shlomchik MJ, Selvaraj P, Ahmed R. Antibody effector functions mediated by Fcγ-receptors are compromised during persistent viral infection. Immunity. 42: 367-78. PMID 25680276 DOI: 10.1016/j.immuni.2015.01.009  0.8
2015 Zhu C, Sakuishi K, Xiao S, Sun Z, Zaghouani S, Gu G, Wang C, Tan DJ, Wu C, Rangachari M, Pertel T, Jin HT, Ahmed R, Anderson AC, Kuchroo VK. An IL-27/NFIL3 signalling axis drives Tim-3 and IL-10 expression and T-cell dysfunction. Nature Communications. 6: 6072. PMID 25614966 DOI: 10.1038/ncomms7072  0.8
2015 Penaloza-MacMaster P, Barber DL, Wherry EJ, Provine NM, Teigler JE, Parenteau L, Blackmore S, Borducchi EN, Larocca RA, Yates KB, Shen H, Haining WN, Sommerstein R, Pinschewer DD, Ahmed R, et al. Vaccine-elicited CD4 T cells induce immunopathology after chronic LCMV infection. Science (New York, N.Y.). 347: 278-82. PMID 25593185 DOI: 10.1126/science.aaa2148  0.8
2015 Chiu C, Ellebedy AH, Wrammert J, Ahmed R. B cell responses to influenza infection and vaccination. Current Topics in Microbiology and Immunology. 386: 381-98. PMID 25193634 DOI: 10.1007/82_2014_425  0.8
2015 Kamphorst AO, Araki K, Ahmed R. Beyond adjuvants: Immunomodulation strategies to enhance T cell immunity Vaccine. 33: B21-B28. DOI: 10.1016/j.vaccine.2014.12.082  0.8
2014 Xu X, Araki K, Li S, Han JH, Ye L, Tan WG, Konieczny BT, Bruinsma MW, Martinez J, Pearce EL, Green DR, Jones DP, Virgin HW, Ahmed R. Autophagy is essential for effector CD8(+) T cell survival and memory formation. Nature Immunology. 15: 1152-61. PMID 25362489 DOI: 10.1038/ni.3025  0.8
2014 Ellebedy AH, Krammer F, Li GM, Miller MS, Chiu C, Wrammert J, Chang CY, Davis CW, McCausland M, Elbein R, Edupuganti S, Spearman P, Andrews SF, Wilson PC, García-Sastre A, ... ... Ahmed R, et al. Induction of broadly cross-reactive antibody responses to the influenza HA stem region following H5N1 vaccination in humans. Proceedings of the National Academy of Sciences of the United States of America. 111: 13133-8. PMID 25157133 DOI: 10.1073/pnas.1414070111  0.8
2014 Penaloza-MacMaster P, Kamphorst AO, Wieland A, Araki K, Iyer SS, West EE, O'Mara L, Yang S, Konieczny BT, Sharpe AH, Freeman GJ, Rudensky AY, Ahmed R. Interplay between regulatory T cells and PD-1 in modulating T cell exhaustion and viral control during chronic LCMV infection. The Journal of Experimental Medicine. 211: 1905-18. PMID 25113973 DOI: 10.1084/jem.20132577  0.8
2014 Austin JW, Lu P, Majumder P, Ahmed R, Boss JM. STAT3, STAT4, NFATc1, and CTCF regulate PD-1 through multiple novel regulatory regions in murine T cells. Journal of Immunology (Baltimore, Md. : 1950). 192: 4876-86. PMID 24711622 DOI: 10.4049/jimmunol.1302750  0.8
2014 Chiu C, McCausland M, Sidney J, Duh FM, Rouphael N, Mehta A, Mulligan M, Carrington M, Wieland A, Sullivan NL, Weinberg A, Levin MJ, Pulendran B, Peters B, Sette A, ... Ahmed R, et al. Broadly reactive human CD8 T cells that recognize an epitope conserved between VZV, HSV and EBV. Plos Pathogens. 10: e1004008. PMID 24675761 DOI: 10.1371/journal.ppat.1004008  0.8
2014 Lu P, Youngblood BA, Austin JW, Mohammed AU, Butler R, Ahmed R, Boss JM. Blimp-1 represses CD8 T cell expression of PD-1 using a feed-forward transcriptional circuit during acute viral infection. The Journal of Experimental Medicine. 211: 515-27. PMID 24590765 DOI: 10.1084/jem.20130208  0.8
2014 Araki K, Youngblood B, Ahmed R. Programmed Cell Death 1-Directed Immunotherapy for Enhancing T-Cell Function. Cold Spring Harbor Symposia On Quantitative Biology. PMID 24415643 DOI: 10.1101/sqb.78.019869  0.8
2014 Porichis F, Hart MG, Zupkosky J, Barblu L, Kwon DS, McMullen A, Brennan T, Ahmed R, Freeman GJ, Kavanagh DG, Kaufmann DE. Differential impact of PD-1 and/or interleukin-10 blockade on HIV-1-specific CD4 T cell and antigen-presenting cell functions. Journal of Virology. 88: 2508-18. PMID 24352453 DOI: 10.1128/JVI.02034-13  0.8
2013 Araki K, Youngblood B, Ahmed R. Programmed cell death 1-directed immunotherapy for enhancing T-cell function. Cold Spring Harbor Symposia On Quantitative Biology. 78: 239-47. PMID 25028401 DOI: 10.1101/sqb.2013.78.019869  0.36
2013 Iyer SS, Latner DR, Zilliox MJ, McCausland M, Akondy RS, Penaloza-Macmaster P, Hale JS, Ye L, Mohammed AU, Yamaguchi T, Sakaguchi S, Amara RR, Ahmed R. Identification of novel markers for mouse CD4(+) T follicular helper cells. European Journal of Immunology. 43: 3219-32. PMID 24030473 DOI: 10.1002/eji.201343469  0.8
2013 Saha A, Aoyama K, Taylor PA, Koehn BH, Veenstra RG, Panoskaltsis-Mortari A, Munn DH, Murphy WJ, Azuma M, Yagita H, Fife BT, Sayegh MH, Najafian N, Socie G, Ahmed R, et al. Host programmed death ligand 1 is dominant over programmed death ligand 2 expression in regulating graft-versus-host disease lethality. Blood. 122: 3062-73. PMID 24030385 DOI: 10.1182/blood-2013-05-500801  0.32
2013 Kamphorst AO, Ahmed R. CD4 T-cell immunotherapy for chronic viral infections and cancer. Immunotherapy. 5: 975-87. PMID 23998732 DOI: 10.2217/imt.13.91  0.8
2013 Fuller MJ, Callendret B, Zhu B, Freeman GJ, Hasselschwert DL, Satterfield W, Sharpe AH, Dustin LB, Rice CM, Grakoui A, Ahmed R, Walker CM. Immunotherapy of chronic hepatitis C virus infection with antibodies against programmed cell death-1 (PD-1). Proceedings of the National Academy of Sciences of the United States of America. 110: 15001-6. PMID 23980172 DOI: 10.1073/pnas.1312772110  0.8
2013 Scharer CD, Barwick BG, Youngblood BA, Ahmed R, Boss JM. Global DNA methylation remodeling accompanies CD8 T cell effector function. Journal of Immunology (Baltimore, Md. : 1950). 191: 3419-29. PMID 23956425 DOI: 10.4049/jimmunol.1301395  0.8
2013 Li Y, Myers JL, Bostick DL, Sullivan CB, Madara J, Linderman SL, Liu Q, Carter DM, Wrammert J, Esposito S, Principi N, Plotkin JB, Ross TM, Ahmed R, Wilson PC, et al. Immune history shapes specificity of pandemic H1N1 influenza antibody responses. The Journal of Experimental Medicine. 210: 1493-500. PMID 23857983 DOI: 10.1084/jem.20130212  0.8
2013 Ahmed R, Burton DR. Viral vaccines: past successes and future challenges. Current Opinion in Virology. 3: 307-8. PMID 23809262 DOI: 10.1016/j.coviro.2013.06.007  0.8
2013 Youngblood B, Noto A, Porichis F, Akondy RS, Ndhlovu ZM, Austin JW, Bordi R, Procopio FA, Miura T, Allen TM, Sidney J, Sette A, Walker BD, Ahmed R, Boss JM, et al. Cutting edge: Prolonged exposure to HIV reinforces a poised epigenetic program for PD-1 expression in virus-specific CD8 T cells. Journal of Immunology (Baltimore, Md. : 1950). 191: 540-4. PMID 23772031 DOI: 10.4049/jimmunol.1203161  0.8
2013 Bodewes R, Geelhoed-Mieras MM, Wrammert J, Ahmed R, Wilson PC, Fouchier RA, Osterhaus AD, Rimmelzwaan GF. In vitro assessment of the immunological significance of a human monoclonal antibody directed to the influenza a virus nucleoprotein. Clinical and Vaccine Immunology : Cvi. 20: 1333-7. PMID 23761662 DOI: 10.1128/CVI.00339-13  0.8
2013 Koff WC, Burton DR, Johnson PR, Walker BD, King CR, Nabel GJ, Ahmed R, Bhan MK, Plotkin SA. Accelerating next-generation vaccine development for global disease prevention. Science (New York, N.Y.). 340: 1232910. PMID 23723240 DOI: 10.1126/science.1232910  0.8
2013 West EE, Jin HT, Rasheed AU, Penaloza-Macmaster P, Ha SJ, Tan WG, Youngblood B, Freeman GJ, Smith KA, Ahmed R. PD-L1 blockade synergizes with IL-2 therapy in reinvigorating exhausted T cells. The Journal of Clinical Investigation. 123: 2604-15. PMID 23676462 DOI: 10.1172/JCI67008  0.8
2013 Rasheed MA, Latner DR, Aubert RD, Gourley T, Spolski R, Davis CW, Langley WA, Ha SJ, Ye L, Sarkar S, Kalia V, Konieczny BT, Leonard WJ, Ahmed R. Interleukin-21 is a critical cytokine for the generation of virus-specific long-lived plasma cells. Journal of Virology. 87: 7737-46. PMID 23637417 DOI: 10.1128/JVI.00063-13  0.8
2013 Wei F, Zhong S, Ma Z, Kong H, Medvec A, Ahmed R, Freeman GJ, Krogsgaard M, Riley JL. Strength of PD-1 signaling differentially affects T-cell effector functions. Proceedings of the National Academy of Sciences of the United States of America. 110: E2480-9. PMID 23610399 DOI: 10.1073/pnas.1305394110  0.8
2013 Lau LL, Jamieson BD, Somasundaram T, Ahmed R. Pillars Article: Cytotoxic T-cell Memory without Antigen. Nature. 1994. 369: 648-652. Journal of Immunology (Baltimore, Md. : 1950). 190: 4445-9. PMID 23606721  0.8
2013 Hale JS, Youngblood B, Latner DR, Mohammed AU, Ye L, Akondy RS, Wu T, Iyer SS, Ahmed R. Distinct memory CD4+ T cells with commitment to T follicular helper- and T helper 1-cell lineages are generated after acute viral infection. Immunity. 38: 805-17. PMID 23583644 DOI: 10.1016/j.immuni.2013.02.020  0.8
2013 Kamphorst AO, Ahmed R. Manipulating the PD-1 pathway to improve immunity. Current Opinion in Immunology. 25: 381-8. PMID 23582509 DOI: 10.1016/j.coi.2013.03.003  0.8
2013 Araki K, Ahmed R. AMPK: a metabolic switch for CD8+ T-cell memory. European Journal of Immunology. 43: 878-81. PMID 23504580 DOI: 10.1002/eji.201343483  0.8
2013 Chiu C, Wrammert J, Li GM, McCausland M, Wilson PC, Ahmed R. Cross-reactive humoral responses to influenza and their implications for a universal vaccine. Annals of the New York Academy of Sciences. 1283: 13-21. PMID 23405860 DOI: 10.1111/nyas.12012  0.8
2013 Youngblood B, Hale JS, Ahmed R. T-cell memory differentiation: insights from transcriptional signatures and epigenetics. Immunology. 139: 277-84. PMID 23347146 DOI: 10.1111/imm.12074  0.8
2013 Brooke CB, Ince WL, Wrammert J, Ahmed R, Wilson PC, Bennink JR, Yewdell JW. Most influenza a virions fail to express at least one essential viral protein. Journal of Virology. 87: 3155-62. PMID 23283949 DOI: 10.1128/JVI.02284-12  0.8
2013 Edupuganti S, Eidex RB, Keyserling H, Akondy RS, Lanciotti R, Orenstein W, del Rio C, Pan Y, Querec T, Lipman H, Barrett A, Ahmed R, Teuwen D, Cetron M, Mulligan MJ, et al. A randomized, double-blind, controlled trial of the 17D yellow fever virus vaccine given in combination with immune globulin or placebo: comparative viremia and immunogenicity. The American Journal of Tropical Medicine and Hygiene. 88: 172-7. PMID 23208880 DOI: 10.4269/ajtmh.2012.12-0179  0.8
2013 Tan WG, Jin HT, West EE, Penaloza-MacMaster P, Wieland A, Zilliox MJ, McElrath MJ, Barouch DH, Ahmed R. Comparative analysis of simian immunodeficiency virus gag-specific effector and memory CD8+ T cells induced by different adenovirus vectors. Journal of Virology. 87: 1359-72. PMID 23175355 DOI: 10.1128/JVI.02055-12  0.8
2013 Choi D, Song MY, Im SJ, Jin HT, Lee SW, Ahmed R, Sung YC. Effect of DNA vaccine following PD-1/IL-10R blockade treatment in two chimpanzees chronically infected with HCV Gene Therapy and Molecular Biology. 15: 38-51.  0.8
2012 Xu X, Ye L, Araki K, Ahmed R. mTOR, linking metabolism and immunity. Seminars in Immunology. 24: 429-35. PMID 23352227 DOI: 10.1016/j.smim.2012.12.005  0.8
2012 Burton DR, Ahmed R, Barouch DH, Butera ST, Crotty S, Godzik A, Kaufmann DE, McElrath MJ, Nussenzweig MC, Pulendran B, Scanlan CN, Schief WR, Silvestri G, Streeck H, Walker BD, et al. A Blueprint for HIV Vaccine Discovery. Cell Host & Microbe. 12: 396-407. PMID 23084910 DOI: 10.1016/j.chom.2012.09.008  0.8
2012 Quinn CP, Sabourin CL, Niemuth NA, Li H, Semenova VA, Rudge TL, Mayfield HJ, Schiffer J, Mittler RS, Ibegbu CC, Wrammert J, Ahmed R, Brys AM, Hunt RE, Levesque D, et al. A three-dose intramuscular injection schedule of anthrax vaccine adsorbed generates sustained humoral and cellular immune responses to protective antigen and provides long-term protection against inhalation anthrax in rhesus macaques. Clinical and Vaccine Immunology : Cvi. 19: 1730-45. PMID 22933399 DOI: 10.1128/CVI.00324-12  0.8
2012 Lederman ER, Davidson W, Groff HL, Smith SK, Warkentien T, Li Y, Wilkins KA, Karem KL, Akondy RS, Ahmed R, Frace M, Shieh WJ, Zaki S, Hruby DE, Painter WP, et al. Progressive vaccinia: case description and laboratory-guided therapy with vaccinia immune globulin, ST-246, and CMX001. The Journal of Infectious Diseases. 206: 1372-85. PMID 22904336 DOI: 10.1093/infdis/jis510  0.8
2012 Yoon HS, Scharer CD, Majumder P, Davis CW, Butler R, Zinzow-Kramer W, Skountzou I, Koutsonanos DG, Ahmed R, Boss JM. ZBTB32 is an early repressor of the CIITA and MHC class II gene expression during B cell differentiation to plasma cells. Journal of Immunology (Baltimore, Md. : 1950). 189: 2393-403. PMID 22851713 DOI: 10.4049/jimmunol.1103371  0.8
2012 Feinberg MB, Ahmed R. Born this way? Understanding the immunological basis of effective HIV control. Nature Immunology. 13: 632-4. PMID 22713821 DOI: 10.1038/ni.2351  0.8
2012 Wu T, Wieland A, Araki K, Davis CW, Ye L, Hale JS, Ahmed R. Temporal expression of microRNA cluster miR-17-92 regulates effector and memory CD8+ T-cell differentiation. Proceedings of the National Academy of Sciences of the United States of America. 109: 9965-70. PMID 22665768 DOI: 10.1073/pnas.1207327109  0.8
2012 O'Donnell CD, Vogel L, Wright A, Das SR, Wrammert J, Li GM, McCausland M, Zheng NY, Yewdell JW, Ahmed R, Wilson PC, Subbarao K. Antibody pressure by a human monoclonal antibody targeting the 2009 pandemic H1N1 virus hemagglutinin drives the emergence of a virus with increased virulence in mice. Mbio. 3. PMID 22647789 DOI: 10.1128/mBio.00120-12  0.8
2012 Li GM, Chiu C, Wrammert J, McCausland M, Andrews SF, Zheng NY, Lee JH, Huang M, Qu X, Edupuganti S, Mulligan M, Das SR, Yewdell JW, Mehta AK, Wilson PC, ... Ahmed R, et al. Pandemic H1N1 influenza vaccine induces a recall response in humans that favors broadly cross-reactive memory B cells. Proceedings of the National Academy of Sciences of the United States of America. 109: 9047-52. PMID 22615367 DOI: 10.1073/pnas.1118979109  0.8
2012 Ellebedy AH, Ahmed R. Re-engaging cross-reactive memory B cells: the influenza puzzle. Frontiers in Immunology. 3: 53. PMID 22566934 DOI: 10.3389/fimmu.2012.00053  0.8
2012 Lin JX, Li P, Liu D, Jin HT, He J, Ata Ur Rasheed M, Rochman Y, Wang L, Cui K, Liu C, Kelsall BL, Ahmed R, Leonard WJ. Critical Role of STAT5 transcription factor tetramerization for cytokine responses and normal immune function. Immunity. 36: 586-99. PMID 22520852 DOI: 10.1016/j.immuni.2012.02.017  0.8
2012 Johnson PL, Kochin BF, Ahmed R, Antia R. How do antigenically varying pathogens avoid cross-reactive responses to invariant antigens? Proceedings. Biological Sciences / the Royal Society. 279: 2777-85. PMID 22438498 DOI: 10.1098/rspb.2012.0005  0.8
2012 Wrammert J, Onlamoon N, Akondy RS, Perng GC, Polsrila K, Chandele A, Kwissa M, Pulendran B, Wilson PC, Wittawatmongkol O, Yoksan S, Angkasekwinai N, Pattanapanyasat K, Chokephaibulkit K, Ahmed R. Rapid and massive virus-specific plasmablast responses during acute dengue virus infection in humans. Journal of Virology. 86: 2911-8. PMID 22238318 DOI: 10.1128/JVI.06075-11  0.8
2012 Zinzow-Kramer WM, Long AB, Youngblood BA, Rosenthal KM, Butler R, Mohammed AU, Skountzou I, Ahmed R, Evavold BD, Boss JM. CIITA promoter I CARD-deficient mice express functional MHC class II genes in myeloid and lymphoid compartments. Genes and Immunity. 13: 299-310. PMID 22218223 DOI: 10.1038/gene.2011.86  0.8
2012 Youngblood B, Wherry EJ, Ahmed R. Acquired transcriptional programming in functional and exhausted virus-specific CD8 T cells. Current Opinion in Hiv and Aids. 7: 50-7. PMID 22134341 DOI: 10.1097/COH.0b013e32834ddcf2  0.8
2012 Iyer SS, Chatraw JH, Tan WG, Wherry EJ, Becker TC, Ahmed R, Kapasi ZF. Protein energy malnutrition impairs homeostatic proliferation of memory CD8 T cells. Journal of Immunology (Baltimore, Md. : 1950). 188: 77-84. PMID 22116826 DOI: 10.4049/jimmunol.1004027  0.8
2011 Aubert RD, Kamphorst AO, Sarkar S, Vezys V, Ha SJ, Barber DL, Ye L, Sharpe AH, Freeman GJ, Ahmed R. Antigen-specific CD4 T-cell help rescues exhausted CD8 T cells during chronic viral infection. Proceedings of the National Academy of Sciences of the United States of America. 108: 21182-7. PMID 22160724 DOI: 10.1073/pnas.1118450109  0.8
2011 Ahmed R, Pulendran B. Learning vaccinology from viral infections. The Journal of Experimental Medicine. 208: 2347-9. PMID 22110181 DOI: 10.1084/jem.20112321  0.8
2011 Walker BD, Ahmed R, Plotkin S. Moving ahead an HIV vaccine: use both arms to beat HIV. Nature Medicine. 17: 1194-5. PMID 21988996 DOI: 10.1038/nm.2529  0.8
2011 Youngblood B, Oestreich KJ, Ha SJ, Duraiswamy J, Akondy RS, West EE, Wei Z, Lu P, Austin JW, Riley JL, Boss JM, Ahmed R. Chronic virus infection enforces demethylation of the locus that encodes PD-1 in antigen-specific CD8(+) T cells. Immunity. 35: 400-12. PMID 21943489 DOI: 10.1016/j.immuni.2011.06.015  0.8
2011 Araki K, Ellebedy AH, Ahmed R. TOR in the immune system. Current Opinion in Cell Biology. 23: 707-15. PMID 21925855 DOI: 10.1016/j.ceb.2011.08.006  0.8
2011 Kotturi MF, Swann JA, Peters B, Arlehamn CL, Sidney J, Kolla RV, James EA, Akondy RS, Ahmed R, Kwok WW, Buchmeier MJ, Sette A. Human CD8⁺ and CD4⁺ T cell memory to lymphocytic choriomeningitis virus infection. Journal of Virology. 85: 11770-80. PMID 21900169 DOI: 10.1128/JVI.05477-11  0.8
2011 West EE, Youngblood B, Tan WG, Jin HT, Araki K, Alexe G, Konieczny BT, Calpe S, Freeman GJ, Terhorst C, Haining WN, Ahmed R. Tight regulation of memory CD8(+) T cells limits their effectiveness during sustained high viral load. Immunity. 35: 285-98. PMID 21856186 DOI: 10.1016/j.immuni.2011.05.017  0.8
2011 De Rosa SC, Thomas EP, Bui J, Huang Y, deCamp A, Morgan C, Kalams SA, Tomaras GD, Akondy R, Ahmed R, Lau CY, Graham BS, Nabel GJ, McElrath MJ. HIV-DNA priming alters T cell responses to HIV-adenovirus vaccine even when responses to DNA are undetectable. Journal of Immunology (Baltimore, Md. : 1950). 187: 3391-401. PMID 21844392 DOI: 10.4049/jimmunol.1101421  0.8
2011 Nakaya HI, Wrammert J, Lee EK, Racioppi L, Marie-Kunze S, Haining WN, Means AR, Kasturi SP, Khan N, Li GM, McCausland M, Kanchan V, Kokko KE, Li S, Elbein R, ... ... Ahmed R, et al. Systems biology of vaccination for seasonal influenza in humans. Nature Immunology. 12: 786-95. PMID 21743478 DOI: 10.1038/ni.2067  0.8
2011 Vezys V, Penaloza-MacMaster P, Barber DL, Ha SJ, Konieczny B, Freeman GJ, Mittler RS, Ahmed R. 4-1BB signaling synergizes with programmed death ligand 1 blockade to augment CD8 T cell responses during chronic viral infection. Journal of Immunology (Baltimore, Md. : 1950). 187: 1634-42. PMID 21742975 DOI: 10.4049/jimmunol.1100077  0.8
2011 Pulendran B, Ahmed R. Immunological mechanisms of vaccination. Nature Immunology. 12: 509-17. PMID 21739679 DOI: 10.1038/ni.2039  0.8
2011 Mandl JN, Akondy R, Lawson B, Kozyr N, Staprans SI, Ahmed R, Feinberg MB. Distinctive TLR7 signaling, type I IFN production, and attenuated innate and adaptive immune responses to yellow fever virus in a primate reservoir host. Journal of Immunology (Baltimore, Md. : 1950). 186: 6406-16. PMID 21515797 DOI: 10.4049/jimmunol.1001191  0.8
2011 Penaloza-MacMaster P, Ur Rasheed A, Iyer SS, Yagita H, Blazar BR, Ahmed R. Opposing effects of CD70 costimulation during acute and chronic lymphocytic choriomeningitis virus infection of mice. Journal of Virology. 85: 6168-74. PMID 21507976 DOI: 10.1128/JVI.02205-10  0.8
2011 Johnson PL, Kochin BF, McAfee MS, Stromnes IM, Regoes RR, Ahmed R, Blattman JN, Antia R. Vaccination alters the balance between protective immunity, exhaustion, escape, and death in chronic infections. Journal of Virology. 85: 5565-70. PMID 21411537 DOI: 10.1128/JVI.00166-11  0.8
2011 Duraiswamy J, Ibegbu CC, Masopust D, Miller JD, Araki K, Doho GH, Tata P, Gupta S, Zilliox MJ, Nakaya HI, Pulendran B, Haining WN, Freeman GJ, Ahmed R. Phenotype, function, and gene expression profiles of programmed death-1(hi) CD8 T cells in healthy human adults. Journal of Immunology (Baltimore, Md. : 1950). 186: 4200-12. PMID 21383243 DOI: 10.4049/jimmunol.1001783  0.8
2011 Turner AP, Shaffer VO, Araki K, Martens C, Turner PL, Gangappa S, Ford ML, Ahmed R, Kirk AD, Larsen CP. Sirolimus enhances the magnitude and quality of viral-specific CD8+ T-cell responses to vaccinia virus vaccination in rhesus macaques. American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons. 11: 613-8. PMID 21342450 DOI: 10.1111/j.1600-6143.2010.03407.x  0.8
2011 Punkosdy GA, Blain M, Glass DD, Lozano MM, O'Mara L, Dudley JP, Ahmed R, Shevach EM. Regulatory T-cell expansion during chronic viral infection is dependent on endogenous retroviral superantigens. Proceedings of the National Academy of Sciences of the United States of America. 108: 3677-82. PMID 21321220 DOI: 10.1073/pnas.1100213108  0.8
2011 Allen SJ, Hamrah P, Gate D, Mott KR, Mantopoulos D, Zheng L, Town T, Jones C, von Andrian UH, Freeman GJ, Sharpe AH, BenMohamed L, Ahmed R, Wechsler SL, Ghiasi H. The role of LAT in increased CD8+ T cell exhaustion in trigeminal ganglia of mice latently infected with herpes simplex virus 1. Journal of Virology. 85: 4184-97. PMID 21307196 DOI: 10.1128/JVI.02290-10  0.8
2011 Ahmed R, Akondy RS. Insights into human CD8(+) T-cell memory using the yellow fever and smallpox vaccines. Immunology and Cell Biology. 89: 340-5. PMID 21301482 DOI: 10.1038/icb.2010.155  0.8
2011 Wrammert J, Koutsonanos D, Li GM, Edupuganti S, Sui J, Morrissey M, McCausland M, Skountzou I, Hornig M, Lipkin WI, Mehta A, Razavi B, Del Rio C, Zheng NY, Lee JH, ... ... Ahmed R, et al. Broadly cross-reactive antibodies dominate the human B cell response against 2009 pandemic H1N1 influenza virus infection. The Journal of Experimental Medicine. 208: 181-93. PMID 21220454 DOI: 10.1084/jem.20101352  0.8
2011 Jin HT, Ahmed R, Okazaki T. Role of PD-1 in regulating T-cell immunity. Current Topics in Microbiology and Immunology. 350: 17-37. PMID 21061197 DOI: 10.1007/82_2010_116  0.8
2011 Chandele A, Mukerjee P, Das G, Ahmed R, Chauhan VS. Phenotypic and functional profiling of malaria-induced CD8 and CD4 T cells during blood-stage infection with Plasmodium yoelii. Immunology. 132: 273-86. PMID 21039472 DOI: 10.1111/j.1365-2567.2010.03363.x  0.8
2011 Wrammert J, Koutsonanos D, Li GM, Edupuganti S, Sui J, Morrissey M, McCausland M, Skountzou I, Hornig M, Lipkin WI, Mehta A, Razavi B, Del Rio C, Zheng NY, Lee JH, ... ... Ahmed R, et al. Broadly cross-reactive antibodies dominate the human B cell response against 2009 pandemic H1N1 influenza virus infection (The Journal of Experimental Medicine (2011) 208, 1, (181-193)) Journal of Experimental Medicine. 208: 411. DOI: 10.1084/jem.201013522082c  0.8
2010 Sallusto F, Lanzavecchia A, Araki K, Ahmed R. From vaccines to memory and back. Immunity. 33: 451-63. PMID 21029957 DOI: 10.1016/j.immuni.2010.10.008  0.8
2010 Araki K, Gangappa S, Dillehay DL, Rouse BT, Larsen CP, Ahmed R. Pathogenic virus-specific T cells cause disease during treatment with the calcineurin inhibitor FK506: implications for transplantation. The Journal of Experimental Medicine. 207: 2355-67. PMID 20921283 DOI: 10.1084/jem.20100124  0.8
2010 Choo DK, Murali-Krishna K, Anita R, Ahmed R. Homeostatic turnover of virus-specific memory CD8 T cells occurs stochastically and is independent of CD4 T cell help. Journal of Immunology (Baltimore, Md. : 1950). 185: 3436-44. PMID 20733203 DOI: 10.4049/jimmunol.1001421  0.8
2010 Youngblood B, Davis CW, Ahmed R. Making memories that last a lifetime: heritable functions of self-renewing memory CD8 T cells. International Immunology. 22: 797-803. PMID 20732857 DOI: 10.1093/intimm/dxq437  0.8
2010 Jin HT, Anderson AC, Tan WG, West EE, Ha SJ, Araki K, Freeman GJ, Kuchroo VK, Ahmed R. Cooperation of Tim-3 and PD-1 in CD8 T-cell exhaustion during chronic viral infection. Proceedings of the National Academy of Sciences of the United States of America. 107: 14733-8. PMID 20679213 DOI: 10.1073/pnas.1009731107  0.8
2010 Mueller SN, Langley WA, Li G, García-Sastre A, Webby RJ, Ahmed R. Qualitatively different memory CD8+ T cells are generated after lymphocytic choriomeningitis virus and influenza virus infections. Journal of Immunology (Baltimore, Md. : 1950). 185: 2182-90. PMID 20639484 DOI: 10.4049/jimmunol.1001142  0.8
2010 Ferrer IR, Wagener ME, Robertson JM, Turner AP, Araki K, Ahmed R, Kirk AD, Larsen CP, Ford ML. Cutting edge: Rapamycin augments pathogen-specific but not graft-reactive CD8+ T cell responses. Journal of Immunology (Baltimore, Md. : 1950). 185: 2004-8. PMID 20631309 DOI: 10.4049/jimmunol.1001176  0.8
2010 Mueller SN, Vanguri VK, Ha SJ, West EE, Keir ME, Glickman JN, Sharpe AH, Ahmed R. PD-L1 has distinct functions in hematopoietic and nonhematopoietic cells in regulating T cell responses during chronic infection in mice. The Journal of Clinical Investigation. 120: 2508-15. PMID 20551512 DOI: 10.1172/JCI40040  0.8
2010 Araki K, Youngblood B, Ahmed R. The role of mTOR in memory CD8 T-cell differentiation. Immunological Reviews. 235: 234-43. PMID 20536567 DOI: 10.1111/j.0105-2896.2010.00898.x  0.8
2010 Kim PS, Ahmed R. Features of responding T cells in cancer and chronic infection. Current Opinion in Immunology. 22: 223-30. PMID 20207527 DOI: 10.1016/j.coi.2010.02.005  0.8
2010 Masopust D, Choo D, Vezys V, Wherry EJ, Duraiswamy J, Akondy R, Wang J, Casey KA, Barber DL, Kawamura KS, Fraser KA, Webby RJ, Brinkmann V, Butcher EC, Newell KA, ... Ahmed R, et al. Dynamic T cell migration program provides resident memory within intestinal epithelium. The Journal of Experimental Medicine. 207: 553-64. PMID 20156972 DOI: 10.1084/jem.20090858  0.8
2010 Kalia V, Sarkar S, Subramaniam S, Haining WN, Smith KA, Ahmed R. Prolonged interleukin-2Ralpha expression on virus-specific CD8+ T cells favors terminal-effector differentiation in vivo. Immunity. 32: 91-103. PMID 20096608 DOI: 10.1016/j.immuni.2009.11.010  0.8
2010 Mueller SN, Langley WA, Carnero E, García-Sastre A, Ahmed R. Immunization with live attenuated influenza viruses that express altered NS1 proteins results in potent and protective memory CD8+ T-cell responses. Journal of Virology. 84: 1847-55. PMID 19939929 DOI: 10.1128/JVI.01317-09  0.8
2009 Akondy RS, Monson ND, Miller JD, Edupuganti S, Teuwen D, Wu H, Quyyumi F, Garg S, Altman JD, Del Rio C, Keyserling HL, Ploss A, Rice CM, Orenstein WA, Mulligan MJ, ... Ahmed R, et al. The yellow fever virus vaccine induces a broad and polyfunctional human memory CD8+ T cell response. Journal of Immunology (Baltimore, Md. : 1950). 183: 7919-30. PMID 19933869 DOI: 10.4049/jimmunol.0803903  0.8
2009 Penaloza-MacMaster P, Masopust D, Ahmed R. T-cell reconstitution without T-cell immunopathology in two models of T-cell-mediated tissue destruction. Immunology. 128: 164-71. PMID 19740373 DOI: 10.1111/j.1365-2567.2009.03080.x  0.8
2009 Ahmed R, Bevan MJ, Reiner SL, Fearon DT. The precursors of memory: models and controversies. Nature Reviews. Immunology. 9: 662-8. PMID 19680250 DOI: 10.1038/nri2619  0.8
2009 Virgin HW, Wherry EJ, Ahmed R. Redefining chronic viral infection. Cell. 138: 30-50. PMID 19596234 DOI: 10.1016/j.cell.2009.06.036  0.8
2009 Blattman JN, Wherry EJ, Ha SJ, van der Most RG, Ahmed R. Impact of epitope escape on PD-1 expression and CD8 T-cell exhaustion during chronic infection. Journal of Virology. 83: 4386-94. PMID 19211743 DOI: 10.1128/JVI.02524-08  0.8
2009 Whitmire JK, Asano MS, Kaech SM, Sarkar S, Hannum LG, Shlomchik MJ, Ahmed R. Requirement of B cells for generating CD4+ T cell memory. Journal of Immunology (Baltimore, Md. : 1950). 182: 1868-76. PMID 19201839 DOI: 10.4049/jimmunol.0802501  0.76
2008 Haining WN, Ebert BL, Subrmanian A, Wherry EJ, Eichbaum Q, Evans JW, Mak R, Rivoli S, Pretz J, Angelosanto J, Smutko JS, Walker BD, Kaech SM, Ahmed R, Nadler LM, et al. Identification of an evolutionarily conserved transcriptional signature of CD8 memory differentiation that is shared by T and B cells. Journal of Immunology (Baltimore, Md. : 1950). 181: 1859-68. PMID 18641323  0.8
2008 Ha SJ, West EE, Araki K, Smith KA, Ahmed R. Manipulating both the inhibitory and stimulatory immune system towards the success of therapeutic vaccination against chronic viral infections. Immunological Reviews. 223: 317-33. PMID 18613845 DOI: 10.1111/j.1600-065X.2008.00638.x  0.4
2008 Wrammert J, Smith K, Miller J, Langley WA, Kokko K, Larsen C, Zheng NY, Mays I, Garman L, Helms C, James J, Air GM, Capra JD, Ahmed R, Wilson PC. Rapid cloning of high-affinity human monoclonal antibodies against influenza virus. Nature. 453: 667-71. PMID 18449194 DOI: 10.1038/nature06890  0.8
2008 Chatraw JH, Wherry EJ, Ahmed R, Kapasi ZF. Diminished primary CD8 T cell response to viral infection during protein energy malnutrition in mice is due to changes in microenvironment and low numbers of viral-specific CD8 T cell precursors. The Journal of Nutrition. 138: 806-12. PMID 18356339  0.8
2008 Ha SJ, Mueller SN, Wherry EJ, Barber DL, Aubert RD, Sharpe AH, Freeman GJ, Ahmed R. Enhancing therapeutic vaccination by blocking PD-1-mediated inhibitory signals during chronic infection. The Journal of Experimental Medicine. 205: 543-55. PMID 18332181 DOI: 10.1084/jem.20071949  0.8
2007 Sarkar S, Teichgräber V, Kalia V, Polley A, Masopust D, Harrington LE, Ahmed R, Wherry EJ. Strength of stimulus and clonal competition impact the rate of memory CD8 T cell differentiation. Journal of Immunology (Baltimore, Md. : 1950). 179: 6704-14. PMID 17982060  0.8
2007 Masopust D, Vezys V, Wherry EJ, Ahmed R. A brief history of CD8 T cells. European Journal of Immunology. 37: S103-10. PMID 17972353 DOI: 10.1002/eji.200737584  0.8
2007 Ahmed R, Oldstone MB, Palese P. Protective immunity and susceptibility to infectious diseases: lessons from the 1918 influenza pandemic. Nature Immunology. 8: 1188-93. PMID 17952044 DOI: 10.1038/ni1530  0.8
2007 Wherry EJ, Ha SJ, Kaech SM, Haining WN, Sarkar S, Kalia V, Subramaniam S, Blattman JN, Barber DL, Ahmed R. Molecular signature of CD8+ T cell exhaustion during chronic viral infection. Immunity. 27: 670-84. PMID 17950003 DOI: 10.1016/j.immuni.2007.09.006  0.8
2007 Sharpe AH, Wherry EJ, Ahmed R, Freeman GJ. The function of programmed cell death 1 and its ligands in regulating autoimmunity and infection. Nature Immunology. 8: 239-45. PMID 17304234 DOI: 10.1038/ni1443  0.8
2007 Radziewicz H, Ibegbu CC, Fernandez ML, Workowski KA, Obideen K, Wehbi M, Hanson HL, Steinberg JP, Masopust D, Wherry EJ, Altman JD, Rouse BT, Freeman GJ, Ahmed R, Grakoui A. Liver-infiltrating lymphocytes in chronic human hepatitis C virus infection display an exhausted phenotype with high levels of PD-1 and low levels of CD127 expression. Journal of Virology. 81: 2545-53. PMID 17182670 DOI: 10.1128/JVI.02021-06  0.8
2006 Freeman GJ, Wherry EJ, Ahmed R, Sharpe AH. Reinvigorating exhausted HIV-specific T cells via PD-1-PD-1 ligand blockade. The Journal of Experimental Medicine. 203: 2223-7. PMID 17000870 DOI: 10.1084/jem.20061800  0.8
2006 Day CL, Kaufmann DE, Kiepiela P, Brown JA, Moodley ES, Reddy S, Mackey EW, Miller JD, Leslie AJ, DePierres C, Mncube Z, Duraiswamy J, Zhu B, Eichbaum Q, Altfeld M, ... ... Ahmed R, et al. PD-1 expression on HIV-specific T cells is associated with T-cell exhaustion and disease progression. Nature. 443: 350-4. PMID 16921384 DOI: 10.1038/nature05115  0.8
2006 Wherry EJ, Day CL, Draenert R, Miller JD, Kiepiela P, Woodberry T, Brander C, Addo M, Klenerman P, Ahmed R, Walker BD. HIV-specific CD8 T cells express low levels of IL-7Ralpha: implications for HIV-specific T cell memory. Virology. 353: 366-73. PMID 16860834 DOI: 10.1016/j.virol.2006.06.017  0.8
2006 Crotty S, McCausland MM, Aubert RD, Wherry EJ, Ahmed R. Hypogammaglobulinemia and exacerbated CD8 T-cell-mediated immunopathology in SAP-deficient mice with chronic LCMV infection mimics human XLP disease. Blood. 108: 3085-93. PMID 16788096 DOI: 10.1182/blood-2006-04-018929  0.8
2006 Masopust D, Vezys V, Wherry EJ, Barber DL, Ahmed R. Cutting edge: gut microenvironment promotes differentiation of a unique memory CD8 T cell population. Journal of Immunology (Baltimore, Md. : 1950). 176: 2079-83. PMID 16455963  0.8
2006 Barber DL, Wherry EJ, Masopust D, Zhu B, Allison JP, Sharpe AH, Freeman GJ, Ahmed R. Restoring function in exhausted CD8 T cells during chronic viral infection. Nature. 439: 682-7. PMID 16382236 DOI: 10.1038/nature04444  0.8
2005 Intlekofer AM, Takemoto N, Wherry EJ, Longworth SA, Northrup JT, Palanivel VR, Mullen AC, Gasink CR, Kaech SM, Miller JD, Gapin L, Ryan K, Russ AP, Lindsten T, Orange JS, ... ... Ahmed R, et al. Effector and memory CD8+ T cell fate coupled by T-bet and eomesodermin. Nature Immunology. 6: 1236-44. PMID 16273099 DOI: 10.1038/ni1268  0.8
2005 Wherry EJ, Blattman JN, Ahmed R. Low CD8 T-cell proliferative potential and high viral load limit the effectiveness of therapeutic vaccination. Journal of Virology. 79: 8960-8. PMID 15994790 DOI: 10.1128/JVI.79.14.8960-8968.2005  0.8
2005 Manders PM, Hunter PJ, Telaranta AI, Carr JM, Marshall JL, Carrasco M, Murakami Y, Palmowski MJ, Cerundolo V, Kaech SM, Ahmed R, Fearon DT. BCL6b mediates the enhanced magnitude of the secondary response of memory CD8+ T lymphocytes. Proceedings of the National Academy of Sciences of the United States of America. 102: 7418-25. PMID 15833813 DOI: 10.1073/pnas.0501585102  0.8
2005 Becker TC, Coley SM, Wherry EJ, Ahmed R. Bone marrow is a preferred site for homeostatic proliferation of memory CD8 T cells. Journal of Immunology (Baltimore, Md. : 1950). 174: 1269-73. PMID 15661882  0.8
2004 Mandal M, Kawamura KS, Wherry EJ, Ahmed R, Lee KD. Cytosolic delivery of viral nucleoprotein by listeriolysin O-liposome induces enhanced specific cytotoxic T lymphocyte response and protective immunity. Molecular Pharmaceutics. 1: 2-8. PMID 15832496  0.8
2004 Gourley TS, Wherry EJ, Masopust D, Ahmed R. Generation and maintenance of immunological memory. Seminars in Immunology. 16: 323-33. PMID 15528077 DOI: 10.1016/j.smim.2004.08.013  0.8
2004 Wherry EJ, Barber DL, Kaech SM, Blattman JN, Ahmed R. Antigen-independent memory CD8 T cells do not develop during chronic viral infection. Proceedings of the National Academy of Sciences of the United States of America. 101: 16004-9. PMID 15505208 DOI: 10.1073/pnas.0407192101  0.8
2004 Sabbagh L, Kaech SM, Bourbonnière M, Woo M, Cohen LY, Haddad EK, Labrecque N, Ahmed R, Sékaly RP. The selective increase in caspase-3 expression in effector but not memory T cells allows susceptibility to apoptosis. Journal of Immunology (Baltimore, Md. : 1950). 173: 5425-33. PMID 15494489  0.8
2004 Latner DR, Kaech SM, Ahmed R. Enhanced expression of cell cycle regulatory genes in virus-specific memory CD8+ T cells. Journal of Virology. 78: 10953-9. PMID 15452215 DOI: 10.1128/JVI.78.20.10953-10959.2004  0.76
2004 Quinn CP, Dull PM, Semenova V, Li H, Crotty S, Taylor TH, Steward-Clark E, Stamey KL, Schmidt DS, Stinson KW, Freeman AE, Elie CM, Martin SK, Greene C, Aubert RD, ... ... Ahmed R, et al. Immune responses to Bacillus anthracis protective antigen in patients with bioterrorism-related cutaneous or inhalation anthrax. The Journal of Infectious Diseases. 190: 1228-36. PMID 15346332 DOI: 10.1086/423937  0.8
2004 Wherry EJ, Ahmed R. Memory CD8 T-cell differentiation during viral infection. Journal of Virology. 78: 5535-45. PMID 15140950 DOI: 10.1128/JVI.78.11.5535-5545.2004  0.8
2004 Wu Z, Roberts M, Porter M, Walker F, Wherry EJ, Kelly J, Gadina M, Silva EM, DosReis GA, Lopes MF, O'Shea J, Leonard WJ, Ahmed R, Siegel RM. Viral FLIP impairs survival of activated T cells and generation of CD8+ T cell memory. Journal of Immunology (Baltimore, Md. : 1950). 172: 6313-23. PMID 15128821  0.8
2004 Crotty S, Aubert RD, Glidewell J, Ahmed R. Tracking human antigen-specific memory B cells: a sensitive and generalized ELISPOT system. Journal of Immunological Methods. 286: 111-22. PMID 15087226 DOI: 10.1016/j.jim.2003.12.015  0.8
2004 Masopust D, Kaech SM, Wherry EJ, Ahmed R. The role of programming in memory T-cell development. Current Opinion in Immunology. 16: 217-25. PMID 15023416 DOI: 10.1016/j.coi.2004.02.005  0.8
2003 Kaech SM, Tan JT, Wherry EJ, Konieczny BT, Surh CD, Ahmed R. Selective expression of the interleukin 7 receptor identifies effector CD8 T cells that give rise to long-lived memory cells. Nature Immunology. 4: 1191-8. PMID 14625547 DOI: 10.1038/ni1009  0.8
2003 van der Most RG, Murali-Krishna K, Lanier JG, Wherry EJ, Puglielli MT, Blattman JN, Sette A, Ahmed R. Changing immunodominance patterns in antiviral CD8 T-cell responses after loss of epitope presentation or chronic antigenic stimulation. Virology. 315: 93-102. PMID 14592762 DOI: 10.1016/j.virol.2003.07.001  0.8
2003 Barber DL, Wherry EJ, Ahmed R. Cutting edge: rapid in vivo killing by memory CD8 T cells. Journal of Immunology (Baltimore, Md. : 1950). 171: 27-31. PMID 12816979  0.8
2003 Adams AB, Williams MA, Jones TR, Shirasugi N, Durham MM, Kaech SM, Wherry EJ, Onami T, Lanier JG, Kokko KE, Pearson TC, Ahmed R, Larsen CP. Heterologous immunity provides a potent barrier to transplantation tolerance. The Journal of Clinical Investigation. 111: 1887-95. PMID 12813024 DOI: 10.1172/JCI17477  0.8
2003 Kersh EN, Kaech SM, Onami TM, Moran M, Wherry EJ, Miceli MC, Ahmed R. TCR signal transduction in antigen-specific memory CD8 T cells. Journal of Immunology (Baltimore, Md. : 1950). 170: 5455-63. PMID 12759421  0.8
2003 Antia R, Bergstrom CT, Pilyugin SS, Kaech SM, Ahmed R. Models of CD8+ responses: 1. What is the antigen-independent proliferation program. Journal of Theoretical Biology. 221: 585-98. PMID 12713942 DOI: 10.1006/jtbi.2003.3208  0.8
2003 Grayson JM, Laniewski NG, Lanier JG, Ahmed R. Mitochondrial potential and reactive oxygen intermediates in antigen-specific CD8+ T cells during viral infection. Journal of Immunology (Baltimore, Md. : 1950). 170: 4745-51. PMID 12707355  0.8
2003 Blattman JN, Grayson JM, Wherry EJ, Kaech SM, Smith KA, Ahmed R. Therapeutic use of IL-2 to enhance antiviral T-cell responses in vivo. Nature Medicine. 9: 540-7. PMID 12692546 DOI: 10.1038/nm866  0.8
2003 Kaech SM, Ahmed R. Immunology. CD8 T cells remember with a little help. Science (New York, N.Y.). 300: 263-5. PMID 12690179 DOI: 10.1126/science.1084511  0.76
2003 Wherry EJ, Blattman JN, Murali-Krishna K, van der Most R, Ahmed R. Viral persistence alters CD8 T-cell immunodominance and tissue distribution and results in distinct stages of functional impairment. Journal of Virology. 77: 4911-27. PMID 12663797 DOI: 10.1128/JVI.77.8.4911-4927.2003  0.8
2003 Wherry EJ, Teichgräber V, Becker TC, Masopust D, Kaech SM, Antia R, von Andrian UH, Ahmed R. Lineage relationship and protective immunity of memory CD8 T cell subsets. Nature Immunology. 4: 225-34. PMID 12563257 DOI: 10.1038/ni889  0.8
2003 Shen H, Whitmire JK, Fan X, Shedlock DJ, Kaech SM, Ahmed R. A specific role for B cells in the generation of CD8 T cell memory by recombinant Listeria monocytogenes. Journal of Immunology (Baltimore, Md. : 1950). 170: 1443-51. PMID 12538706  0.76
2003 Slifka MK, Blattman JN, Sourdive DJ, Liu F, Huffman DL, Wolfe T, Hughes A, Oldstone MB, Ahmed R, Von Herrath MG. Preferential escape of subdominant CD8+ T cells during negative selection results in an altered antiviral T cell hierarchy. Journal of Immunology (Baltimore, Md. : 1950). 170: 1231-9. PMID 12538681  0.8
2003 Hathcock KS, Kaech SM, Ahmed R, Hodes RJ. Induction of telomerase activity and maintenance of telomere length in virus-specific effector and memory CD8+ T cells. Journal of Immunology (Baltimore, Md. : 1950). 170: 147-52. PMID 12496394  0.76
2002 Kaech SM, Hemby S, Kersh E, Ahmed R. Molecular and functional profiling of memory CD8 T cell differentiation Cell. 111: 837-851. PMID 12526810 DOI: 10.1016/S0092-8674(02)01139-X  0.8
2002 Wherry EJ, Becker TC, Boone D, Kaja MK, Ma A, Ahmed R. Homeostatic proliferation but not the generation of virus specific memory CD8 T cells is impaired in the absence of IL-15 or IL-15Ralpha. Advances in Experimental Medicine and Biology. 512: 165-75. PMID 12405201  0.8
2002 Grayson JM, Harrington LE, Lanier JG, Wherry EJ, Ahmed R. Differential sensitivity of naive and memory CD8+ T cells to apoptosis in vivo. Journal of Immunology (Baltimore, Md. : 1950). 169: 3760-70. PMID 12244170  0.8
2002 Becker TC, Wherry EJ, Boone D, Murali-Krishna K, Antia R, Ma A, Ahmed R. Interleukin 15 is required for proliferative renewal of virus-specific memory CD8 T cells. The Journal of Experimental Medicine. 195: 1541-8. PMID 12070282 DOI: 10.1084/jem.20020369  0.8
2002 Onami TM, Harrington LE, Williams MA, Galvan M, Larsen CP, Pearson TC, Manjunath N, Baum LG, Pearce BD, Ahmed R. Dynamic regulation of T cell immunity by CD43. Journal of Immunology (Baltimore, Md. : 1950). 168: 6022-31. PMID 12055210  0.8
2002 van der Most RG, Harrington LE, Giuggio V, Mahar PL, Ahmed R. Yellow fever virus 17D envelope and NS3 proteins are major targets of the antiviral T cell response in mice. Virology. 296: 117-24. PMID 12036323 DOI: 10.1006/viro.2002.1432  0.8
2002 Harrington LE, Most Rv Rv, Whitton JL, Ahmed R. Recombinant vaccinia virus-induced T-cell immunity: quantitation of the response to the virus vector and the foreign epitope. Journal of Virology. 76: 3329-37. PMID 11884558 DOI: 10.1128/JVI.76.7.3329-3337.2002  0.8
2002 Blattman JN, Antia R, Sourdive DJ, Wang X, Kaech SM, Murali-Krishna K, Altman JD, Ahmed R. Estimating the precursor frequency of naive antigen-specific CD8 T cells. The Journal of Experimental Medicine. 195: 657-64. PMID 11877489 DOI: 10.1084/jem.20001021  0.8
2001 Grayson JM, Lanier JG, Harrington LE, Altman JD, Ahmed R. Analysis of Mitochondrial Function in Antigen Specific na ve, Effector and MEmory CD8 + T Cells. Thescientificworldjournal. 1: 53. PMID 30147516 DOI: 10.1100/tsw.2001.188  0.68
2001 Suresh M, Whitmire JK, Harrington LE, Larsen CP, Pearson TC, Altman JD, Ahmed R. Role of CD28-B7 interactions in generation and maintenance of CD8 T cell memory. Journal of Immunology (Baltimore, Md. : 1950). 167: 5565-73. PMID 11698427  0.8
2001 Williams MA, Tan JT, Adams AB, Durham MM, Shirasugi N, Whitmire JK, Harrington LE, Ahmed R, Pearson TC, Larsen CP. Characterization of virus-mediated inhibition of mixed chimerism and allospecific tolerance. Journal of Immunology (Baltimore, Md. : 1950). 167: 4987-95. PMID 11673506  0.8
2001 Grayson JM, Lanier JG, Altman JD, Ahmed R. The role of p53 in regulating antiviral T cell responses. Journal of Immunology (Baltimore, Md. : 1950). 167: 1333-7. PMID 11466350  0.8
2000 Blattman JN, Sourdive DJ, Murali-Krishna K, Ahmed R, Altman JD. Evolution of the T cell repertoire during primary, memory, and recall responses to viral infection. Journal of Immunology (Baltimore, Md. : 1950). 165: 6081-90. PMID 11086040  0.8
2000 Harrington LE, Galvan M, Baum LG, Altman JD, Ahmed R. Differentiating between memory and effector CD8 T cells by altered expression of cell surface O-glycans. The Journal of Experimental Medicine. 191: 1241-6. PMID 10748241 DOI: 10.1084/jem.191.7.1241  0.8
1999 Lanier JG, Newman MJ, Lee EM, Sette A, Ahmed R. Peptide vaccination using nonionic block copolymers induces protective anti-viral CTL responses. Vaccine. 18: 549-57. PMID 10519946  0.68
1998 Zajac AJ, Blattman JN, Murali-Krishna K, Sourdive DJ, Suresh M, Altman JD, Ahmed R. Viral immune evasion due to persistence of activated T cells without effector function. The Journal of Experimental Medicine. 188: 2205-13. PMID 9858507 DOI: 10.1084/jem.188.12.2205  0.8
1998 Zajac AJ, Murali-Krishna K, Blattman JN, Ahmed R. Therapeutic vaccination against chronic viral infection: the importance of cooperation between CD4+ and CD8+ T cells. Current Opinion in Immunology. 10: 444-9. PMID 9722921 DOI: 10.1016/S0952-7915(98)80119-2  0.8
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