Ronald L. Somerville - Publications

Affiliations: 
Purdue University, West Lafayette, IN, United States 
Area:
Microbiology Biology

79 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2003 Ren SX, Fu G, Jiang XG, Zeng R, Miao YG, Xu H, Zhang YX, Xiong H, Lu G, Lu LF, Jiang HQ, Jia J, Tu YF, Jiang JX, Gu WY, ... ... Somerville RL, et al. Unique physiological and pathogenic features of Leptospira interrogans revealed by whole-genome sequencing. Nature. 422: 888-93. PMID 12712204 DOI: 10.1038/nature01597  1
2001 Wang Y, Zhao S, Somerville RL, Jardetzky O. Solution structure of the DNA-binding domain of the TyrR protein of Haemophilus influenzae. Protein Science : a Publication of the Protein Society. 10: 592-8. PMID 11344327 DOI: 10.1110/ps.45301  1
2001 Kristl S, Zhao S, Falsone SF, Somerville RL, Kungl AJ. The influence of ATP on the association and unfolding of the tyrosine repressor ligand response domain of Haemophilus influenzae. Biochemical and Biophysical Research Communications. 280: 81-4. PMID 11162481 DOI: 10.1006/bbrc.2000.4076  1
2000 Kristl S, Zhao S, Knappe B, Somerville RL, Kungl AJ. The influence of ATP on the binding of aromatic amino acids to the ligand response domain of the tyrosine repressor of Haemophilus influenzae. Febs Letters. 467: 87-90. PMID 10664462 DOI: 10.1016/S0014-5793(00)01118-2  1
2000 Zhao S, Zhu Q, Somerville RL. The sigma(70) transcription factor TyrR has zinc-stimulated phosphatase activity that is inhibited by ATP and tyrosine. Journal of Bacteriology. 182: 1053-61. PMID 10648532 DOI: 10.1128/JB.182.4.1053-1061.2000  1
1999 Yang W, Somerville RL. Antigen mimicry by anti-idiotypic antibodies: Study of interactions between complementary surfaces in macromolecules Methods: a Companion to Methods in Enzymology. 19: 322-329. PMID 10527734 DOI: 10.1006/meth.1999.0859  1
1999 Zhao S, Somerville RL. Isolated operator binding and ligand response domains of the TyrR protein of Haemophilus influenzae associate to reconstitute functional repressor. The Journal of Biological Chemistry. 274: 1842-7. PMID 9880568 DOI: 10.1074/jbc.274.3.1842  1
1998 Bai Q, Somerville RL. Integration host factor and cyclic AMP receptor protein are required for TyrR-mediated activation of tpl in Citrobacter freundii Journal of Bacteriology. 180: 6173-6186. PMID 9829925  1
1997 Smith HQ, Somerville RL. The tpl promoter of Citrobacter freundii is activated by the TyrR protein Journal of Bacteriology. 179: 5914-5921. PMID 9294452  1
1997 Zhu Q, Zhao S, Somerville RL. Expression, purification, and functional analysis of the TyrR protein of Haemophilus influenzae. Protein Expression and Purification. 10: 237-46. PMID 9226720 DOI: 10.1006/prep.1997.0757  1
1995 Chen YW, Dekker EE, Somerville RL. Functional analysis of E. coli threonine dehydrogenase by means of mutant isolation and characterization. Biochimica Et Biophysica Acta. 1253: 208-14. PMID 8519804 DOI: 10.1016/0167-4838(95)00162-2  1
1994 Zhao GP, Somerville RL, Chitnis PR. Synechocystis PCC 6803 contains a single gene for the β subunit of tryptophan synthase with strong homology to the trpB genes of arabidopsis and maize (Zea mays L.) Plant Physiology. 104: 461-466. PMID 8159786  1
1994 Skrypka I, Somerville RL. Nucleotide sequence of the salmonella typhimurium trpr gene Mitochondrial Dna. 4: 355-360. PMID 7841459 DOI: 10.3109/10425179409010185  1
1993 Yang W, Ni L, Somerville RL. A stationary-phase protein of Escherichia coli that affects the mode of association between the trp repressor protein and operator-bearing DNA Proceedings of the National Academy of Sciences of the United States of America. 90: 5796-5800. PMID 8516330  1
1993 Cui J, Ni L, Somerville RL. ATPase activity of TyrR, a transcriptional regulatory protein for σ70 RNA polymerase Journal of Biological Chemistry. 268: 13023-13025. PMID 8514743  1
1993 Cui J, Somerville RL. A mutational analysis of the structural basis for transcriptional activation and monomer-monomer interaction in the TyrR system of Escherichia coli K-12 Journal of Bacteriology. 175: 1777-1784. PMID 8449884  1
1993 Cui J, Somerville RL. The TyrR protein of Escherichia coli, analysis by limited proteolysis of domain structure and ligand-mediated conformational changes Journal of Biological Chemistry. 268: 5040-5047. PMID 8444880  1
1993 Cui J, Somerville RL. Mutational uncoupling of the transcriptional activation function of the TyrR protein of Escherichia coli K-12 from the repression function Journal of Bacteriology. 175: 303-306. PMID 8416907  1
1993 Zhao GP, Somerville RL. A single amino acid switch within the "hinge" region of the tryptophan synthase β subunit of Escherichia coli that leads to diminished association with α subunit and arrested conversion of ESII to product Journal of Biological Chemistry. 268: 14921-14931. PMID 8325869  1
1993 Zhao GP, Somerville RL. An amino acid switch (Gly281 → Arg) within the "Hinge" region of the tryptophan synthase β subunit creates a novel cleavage site for the OmpT protease and selectively diminishes affinity toward a specific monoclonal antibody Journal of Biological Chemistry. 268: 14912-14920. PMID 8325868  1
1992 Cui J, Somerville RL. Physical map location and transcriptional orientation of the tyrR gene of Escherichia coli K-12 Journal of Bacteriology. 174: 3832-3833. PMID 1592836  1
1992 Heatwole VM, Somerville RL. Synergism between the Trp repressor and Tyr repressor in repression of the aroL promoter of Escherichia coli K-12 Journal of Bacteriology. 174: 331-335. PMID 1530846  1
1992 Zeilstra-Ryalls JH, Somerville RL. Protein-protein interaction in the alpha-complementation system of beta-galactosidase Current Topics in Cellular Regulation. 33: 81-104. PMID 1499345  1
1992 Zhao GP, Somerville RL. Genetic and biochemical characterization of the trpB8 mutation of Escherichia coli tryptophan synthase: An amino acid switch at the sharp turn of the trypsin-sensitive "hinge" region diminishes substrate binding and alters solubility Journal of Biological Chemistry. 267: 526-541. PMID 1309752  1
1992 Walker MC, Jones CR, Somerville RL, Sikorski JA. (Z)-3-fluorophosphoenolpyruvate as a pseudosubstrate of EPSP synthase: Enzymatic synthesis of a stable fluoro analog of the catalytic intermediate Journal of the American Chemical Society. 114: 7601-7603.  1
1992 Somerville RL, Hagewood BT, Aronson BD, Tesmer VM. Frameshifted derivatives and promoterless frameshifted derivatives of M13mp18 and M13mp19 useful in the mutational analysis of cloned genes or punctuation elements Methods in Molecular and Cellular Biology. 3: 103-107.  1
1991 Somerville RL, Bogosian G, Zeilstra-Ryalls JH. Shared operator recognition specificity between Trp repressor and the repressors of bacteriophage 434 Journal of Molecular Biology. 217: 599-602. PMID 2005612 DOI: 10.1016/0022-2836(91)90516-9  1
1991 Heatwole VM, Somerville RL. Cloning, nucleotide sequence, and characterization of mtr, the structural gene for a tryptophan-specific permease of Escherichia coli K-12 Journal of Bacteriology. 173: 108-115. PMID 1987112  1
1991 Rex JH, Aronson BD, Somerville RL. The tdh and serA operons of Escherichia coli: Mutational analysis of the regulatory elements of leucine-responsive genes Journal of Bacteriology. 173: 5944-5953. PMID 1917830  1
1991 Heatwole VM, Somerville RL. The tryptophan-specific permease gene, mtr, is differentially regulated by the tryptophan and tyrosine repressors in Escherichia coli K-12 Journal of Bacteriology. 173: 3601-3604. PMID 1904443  1
1991 Somerville RL, Ni Shieh TL, Hagewood B, Cui J. Gene expression from multicopy T7 promoter vectors proceeds at single copy rates in the absence of T7 RNA polymerase Biochemical and Biophysical Research Communications. 181: 1056-1062. PMID 1764057 DOI: 10.1016/0006-291X(91)92044-K  1
1991 Muday GK, Johnson DI, Somerville RL, Herrmann KM. The tyrosine repressor negatively regulates aroH expression in Escherichia coli Journal of Bacteriology. 173: 3930-3932. PMID 1675635  1
1991 Walker MC, Ream JE, Sammons RD, Logusch EW, O'Leary MH, Somerville RL, Sikorski JA. Structural requirements for pep binding To EPSP synthase Bioorganic and Medicinal Chemistry Letters. 1: 683-688. DOI: 10.1016/S0960-894X(01)81048-9  1
1990 Yang SS, Zhang K, Vieira W, Taub JV, Zeilstra-Ryalls JH, Somerville RL. A human hepatocellular carcinoma 3.0-kilobase DNA sequence transforms both rat liver cells and NIH3T3 fibroblasts and encodes a 52-kilodalton protein Cancer Research. 50. PMID 2167164  1
1990 Zeilstra-Ryalls JH, Somerville RL. Fragment tagging Gene Analysis Techniques. 7: 151-159. PMID 2076344 DOI: 10.1016/0735-0651(90)90029-F  1
1989 Aronson BD, Somerville RL, Epperly BR, Dekker EE. The primary structure of Escherichia coli L-threonine dehydrogenase. The Journal of Biological Chemistry. 264: 5226-32. PMID 2647748  1
1989 Aronson BD, Levinthal M, Somerville RL. Activation of a cryptic pathway for threonine metabolism via specific IS3-mediated alteration of promoter structure in Escherichia coli Journal of Bacteriology. 171: 5503-5511. PMID 2551888  1
1988 Aronson BD, Ravnikar PD, Somerville RL. Nucleotide sequence of the 2-amino-3-ketobutyrate coenzyme a ligase (kbl) gene of E.coli Nucleic Acids Research. 16: 3586. PMID 3287333 DOI: 10.1093/nar/16.8.3586  1
1988 Somerville RL. The trp promoter of escherichia coli and its exploitation in the design of efficient protein production systems Biotechnology and Genetic Engineering Reviews. 6: 1-41. PMID 3071371 DOI: 10.1080/02648725.1988.10647844  1
1987 Ravnikar PD, Somerville RL. Genetic characterization of a highly efficient alternate pathway of serine biosynthesis in Escherichia coli Journal of Bacteriology. 169: 2611-2617. PMID 3108237  1
1987 Ravnikar PD, Somerville RL. Structural and functional analysis of a cloned segment of Escherichia coli DNA that specifies proteins of a C4 pathway of serine biosynthesis Journal of Bacteriology. 169: 4716-4721. PMID 2820941  1
1986 Ravnikar PD, Somerville RL. Localization of the structural gene for threonine dehydrogenase in Escherichia coli Journal of Bacteriology. 168: 434-436. PMID 3531182  1
1986 Weiss DL, Johnson DI, Weith HL, Somerville RL. Structural analysis of the ileR locus of Escherichia coli K12 Journal of Biological Chemistry. 261: 9966-9971. PMID 3525538  1
1986 Gonzalez JE, Somerville RL. The anthranilate aggregate of Escherichia coli: kinetics of inhibition by tryptophan of phosphoribosyltransferase. Biochemistry and Cell Biology = Biochimie Et Biologie Cellulaire. 64: 681-91. PMID 2428387  1
1985 Tsapakos MJ, Haydock PV, Hermodson M, Somerville RL. Ligand-mediated conformational changes in Trp repressor protein of Escherichia coli probed through limited proteolysis and the use of specific antibodies Journal of Biological Chemistry. 260: 16383-16394. PMID 2415531  1
1985 Makaroff C, Zalkin H, Somerville RL. Analysis of the Escherichia coli purF control region Federation Proceedings. 44.  1
1984 Haydock PV, Somerville RL. Trp holorepressor-trp operator interaction studied by protein distribution analysis Biochemical and Biophysical Research Communications. 119: 926-932. PMID 6370254 DOI: 10.1016/0006-291X(84)90862-3  1
1984 Bogosian G, Somerville RL, Nishi K, Kano Y, Imamoto F. Transcription of the trpR gene of Escherichia coli: An autogeneously regulated system studied by direct measurements of mRNA levels in vivo Mgg Molecular &Amp; General Genetics. 193: 244-250. PMID 6319963 DOI: 10.1007/BF00330675  1
1984 Bogosian G, Somerville RL. Analysis in vivo of factors affecting the control of transcription initiation at promoters containing target sites for Trp repressor Mgg Molecular &Amp; General Genetics. 193: 110-118. PMID 6318045 DOI: 10.1007/BF00327423  1
1984 Johnson DI, Somerville RL. New regulatory genes involved in the control of transcription initiation at the thr and ilv promoters of Escherichia coli K-12 Mgg Molecular &Amp; General Genetics. 195: 70-76. PMID 6092866 DOI: 10.1007/BF00332726  1
1984 Tsapakos MJ, Somerville RL. Ligand-induced conformational changes in TRP repressor modify the accessibility to protease of certain peptide bonds Federation Proceedings. 43.  1
1983 Johnson DI, Somerville RL. Evidence that repression mechanisms can exert control over the thr, leu, and ilv operons of Escherichia coli K-12 Journal of Bacteriology. 155: 49-55. PMID 6408066  1
1983 Haydock PV, Bogosian G, Brechling K, Somerville RL. Studies on the interaction of Trp holorepressor with several operators. Evidence that the target need not be palindromic Journal of Molecular Biology. 170: 1019-1030. PMID 6358517 DOI: 10.1016/S0022-2836(83)80201-0  1
1983 Bogosian G, Haydock PV, Somerville RL. Indolmycin-mediated inhibition and stimulation of transcription at the trp promoter of Escherichia coli Journal of Bacteriology. 153: 1120-1123. PMID 6337120  1
1983 Gupta SC, Weith HL, Somerville RL. Biological limitations on the length of highly repetitive dna sequences that may be stably maintained within piasmid replicons in escherichia coli Bio/Technology. 1: 602-609. DOI: 10.1038/nbt0983-602  1
1980 Singleton CK, Roeder WD, Bogosian G, Somerville RL, Weith HL. DNA sequence of the E. coli trpR gene and prediction of the amino acid sequence of Trp repressor. Nucleic Acids Research. 8: 1551-60. PMID 7001368 DOI: 10.1093/nar/8.7.1551  1
1980 Andrews JC, Somerville RL. Direct selection and analysis of mutational events which diminish the level of expression of the trp operon Journal of Bacteriology. 141: 422-426. PMID 6986366  1
1979 Kano Y, Nakamura H, Somerville RL, Imamoto F. Decay rates of Escherichia coli trp messenger RNA molecules lacking the normal 5′-terminal sequences Mgg Molecular &Amp; General Genetics. 176: 379-384. PMID 392239 DOI: 10.1007/BF00333101  1
1979 Nakamura H, Kano Y, Schlessinger D, Imamoto F, McPartland A, Somerville RL. Translation-uncoupled transcription of promoter-proximal DNA sequences in E. coli strains harboring mutationally-generated constitutive promoters within genes of the trp operon Mgg Molecular &Amp; General Genetics. 172: 127-136. PMID 384142 DOI: 10.1007/BF00268273  1
1979 Hausler B, Somerville RL. Interaction in vivo between strong closely spaced constitutive promoters Journal of Molecular Biology. 127: 353-356. PMID 372543 DOI: 10.1016/0022-2836(79)90335-8  1
1979 Roeder W, Somerville RL. Cloning the trpR gene Mgg Molecular &Amp; General Genetics. 176: 361-368. PMID 160491 DOI: 10.1007/BF00333098  1
1977 Pilch PF, Somerville RL. Periodate oxidation of vicinal hydroxyls: Applications to student experiments Journal of Chemical Education. 54: 449.  1
1976 McPartland A, Somerville RL. Isolation and characterization of mutations creating high efficiency transcription initiation signals within the trp operon of Escherichia coli Journal of Bacteriology. 128: 557-572. PMID 789357  1
1976 Pilch PF, Somerville RL. Fluorine-containing analogues of intermediates in the shikimate pathway Biochemistry. 15: 5315-5320. PMID 11811  1
1976 Yang LM, Somerville RL. Purification and properties of a new aminopeptidase from Escherichia coli K12 Bba - Enzymology. 445: 406-419. PMID 8147 DOI: 10.1016/0005-2744(76)90094-2  1
1974 Somerville RL, Stetson H. Expression of the tryptophan operon in merodiploids of Escherichia coli - II. Effects of polar mutations in the trpE gene Mgg Molecular &Amp; General Genetics. 131: 247-261. PMID 4612330 DOI: 10.1007/BF00267964  1
1974 Kuhn J, Somerville RL. Uptake and utilization of aromatic d-amino acids in Escherichia coli K12 Bba - Biomembranes. 332: 298-312. DOI: 10.1016/0005-2736(74)90382-4  1
1973 Pabst MJ, Kuhn JC, Somerville RL. Feedback regulation in the anthranilate aggregate from wild type and mutant strains of Escherichia coli. The Journal of Biological Chemistry. 248: 901-14. PMID 4567790  1
1972 Kuhn JC, Pabst MJ, Somerville RL. Mutant strains of Escherichia coli K-12 exhibiting enhanced sensitivity to 5-methyltryptophan. Journal of Bacteriology. 112: 93-101. PMID 4404059  1
1971 Pabst MJ, Somerville RL. A comparison of hydroxylamine and N-methylhydroxylamine as probes for the mechanism of action of the anthranilate synthetase of Escherichia coli Journal of Biological Chemistry. 246: 7214-7216. PMID 4943060  1
1971 Stetson H, Somerville RL. Expression of the tryptophan operon in merodiploids of Escherichia coli - I. Gene dosage, gene position and marker effects Mgg Molecular &Amp; General Genetics. 111: 342-351. PMID 4936311 DOI: 10.1007/BF00569786  1
1971 Kuhn J, Somerville RL. Mutant strains of Escherichia coli K12 that use D-amino acids Proceedings of the National Academy of Sciences of the United States of America. 68: 2484-2487. PMID 4400212  1
1971 Brown KD, Somerville RL. Repression of aromatic amino acid biosynthesis in Escherichia coli K-12 Journal of Bacteriology. 108: 386-399. PMID 4399341  1
1967 Somerville RL. Epistasis between deletion mutations in the tryptophan region and mutations affecting the general aromatic pathway in Escherichia coli K-12 Journal of Bacteriology. 94: 1798-1799. PMID 4863984  1
1967 Somerville RL, Elford R. Hydroxamate formation by anthranilate synthetase of Escherichia coli K12 Biochemical and Biophysical Research Communications. 28: 437-444. PMID 4862406  1
1966 Somerville RL. Tryptophan Operon of Escherichia coli: Regulatory Behavior in Salmonella typhimurium Cytoplasm Science. 154: 1585-1587. PMID 5332550  1
1966 Creighton TE, Helinski DR, Somerville RL, Yanofsky C. Comparison of the tryptophan synthetase alpha-subunits of several species of Enterobacteriaceae. Journal of Bacteriology. 91: 1819-26. PMID 5327908  1
1965 SOMERVILLE RL, YANOFSKY C. STUDIES ON THE REGULATION OF TRYPTOPHAN BIOSYNTHESIS IN ESCHERICHIA Journal of Molecular Biology. 11: 747-759. PMID 14338784  1
1964 SOMERVILLE RL, YANOFSKY C. ON THE TRANSLATION OF THE A GENE REGION OF TRYPTOPHAN MESSENGER RNA Journal of Molecular Biology. 8: 616-619. PMID 14153534  1
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