Carl F. Nathan - Publications

Microbiology and Immunology Weill Cornell Medical College, New York, NY, United States 
Immunology, Microbiology Biology

236 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2021 Zhang H, Hsu HC, Kahne SC, Hara R, Zhan W, Jiang X, Burns-Huang K, Ouellette T, Imaeda T, Okamoto R, Kawasaki M, Michino M, Wong TT, Toita A, Yukawa T, ... ... Nathan CF, et al. Macrocyclic Peptides that Selectively Inhibit the Proteasome. Journal of Medicinal Chemistry. PMID 33949190 DOI: 10.1021/acs.jmedchem.1c00296  0.635
2021 Zhang L, Jiang X, Pfau D, Ling Y, Nathan CF. Type I interferon signaling mediates Mycobacterium tuberculosis-induced macrophage death. The Journal of Experimental Medicine. 218. PMID 33125053 DOI: 10.1084/jem.20200887  0.31
2020 Lopez Quezada L, Smith R, Lupoli TJ, Edoo Z, Li X, Gold B, Roberts J, Ling Y, Park SW, Nguyen Q, Schoenen FJ, Li K, Hugonnet JE, Arthur M, Sacchettini JC, ... Nathan C, et al. Activity-Based Protein Profiling Reveals That Cephalosporins Selectively Active on Non-replicating Bind Multiple Protein Families and Spare Peptidoglycan Transpeptidases. Frontiers in Microbiology. 11: 1248. PMID 32655524 DOI: 10.3389/Fmicb.2020.01248  0.344
2020 Schrader SM, Vaubourgeix J, Nathan C. Biology of antimicrobial resistance and approaches to combat it. Science Translational Medicine. 12. PMID 32581135 DOI: 10.1126/Scitranslmed.Aaz6992  0.305
2020 Bryk R, Mundhra S, Jiang X, Wood M, Pfau D, Weber E, Park S, Zhang L, Wilson C, Van der Westhuyzen R, Street L, Chibale K, Zimmerman M, Dartois V, Pastore N, ... ... Nathan C, et al. Potentiation of rifampin activity in a mouse model of tuberculosis by activation of host transcription factor EB. Plos Pathogens. 16: e1008567. PMID 32574211 DOI: 10.1371/Journal.Ppat.1008567  0.432
2019 Mosior J, Bourland R, Soma S, Nathan C, Sacchettini J. Structural Insights into Phosphopantetheinyl Hydrolase PptH from Mycobacterium tuberculosis. Protein Science : a Publication of the Protein Society. PMID 31886928 DOI: 10.1002/Pro.3813  0.346
2019 Zhan W, Hsu HC, Morgan T, Ouellette T, Burns-Huang K, Hara R, Wright AG, Imaeda T, Okamoto R, Sato K, Michino M, Ramjee M, Aso K, Meinke P, Foley M, ... Nathan CF, et al. Selective Phenylimidazole-based Inhibitors of the Mycobacterium tuberculosis Proteasome. Journal of Medicinal Chemistry. PMID 31560200 DOI: 10.1021/Acs.Jmedchem.9B01187  0.426
2019 Lopez Quezada L, Silve S, Kelinske M, Liba A, Diaz Gonzalez C, Kotev M, Goullieux L, Sans S, Roubert C, Lagrange S, Bacqué E, Couturier C, Pellet A, Blanc I, Ferron M, ... ... Nathan C, et al. Bactericidal Disruption of Magnesium Metallostasis in Mycobacterium tuberculosis Is Counteracted by Mutations in the Metal Ion Transporter CorA. Mbio. 10. PMID 31289182 DOI: 10.1128/Mbio.01405-19  0.352
2019 Lopez Quezada L, Li K, McDonald SL, Nguyen Q, Perkowski AJ, Pharr CW, Gold B, Roberts J, McAulay K, Saito K, Somersan Karakaya S, Javidnia PE, Porras de Francisco E, Amieva MM, Dı Az SP, ... ... Nathan C, et al. Dual-Pharmacophore Pyrithione-Containing Cephalosporins Kill Both Replicating and Nonreplicating Mycobacterium tuberculosis. Acs Infectious Diseases. PMID 31184461 DOI: 10.1021/Acsinfecdis.9B00112  0.302
2019 Wu J, Mu R, Sun M, Zhao N, Pan M, Li H, Dong Y, Sun Z, Bai J, Hu M, Nathan CF, Javid B, Liu G. Derivatives of Natural Product Agrimophol as Disruptors of Intrabacterial pH Homeostasis in Mycobacterium tuberculosis. Acs Infectious Diseases. PMID 31016962 DOI: 10.1021/Acsinfecdis.8B00325  0.362
2019 Ballinger E, Mosior J, Hartman T, Burns-Huang K, Gold B, Morris R, Goullieux L, Blanc I, Vaubourgeix J, Lagrange S, Fraisse L, Sans S, Couturier C, Bacqué E, Rhee K, ... ... Nathan C, et al. Opposing reactions in coenzyme A metabolism sensitize to enzyme inhibition. Science (New York, N.Y.). 363. PMID 30705156 DOI: 10.1126/Science.Aau8959  0.349
2018 Early J, Ollinger J, Darby C, Alling T, Mullen S, Casey A, Gold B, Ochoada J, Wiernicki T, Masquelin T, Nathan CF, Hipskind P, Parish T. Identification of compounds with pH-dependent bactericidal activity against Mycobacterium tuberculosis. Acs Infectious Diseases. PMID 30501173 DOI: 10.1021/Acsinfecdis.8B00256  0.789
2018 McAulay K, Saito K, Warrier T, Walsh KF, Mathurin LD, Royal-Mardi G, Lee MH, Ocheretina O, Pape JW, Fitzgerald DW, Nathan CF. Differentially Detectable Mycobacterium tuberculosis Cells in Sputum from Treatment-Naive Subjects in Haiti and Their Proportionate Increase after Initiation of Treatment. Mbio. 9. PMID 30459198 DOI: 10.1128/Mbio.02192-18  0.319
2018 Wu K, Koo J, Jiang X, Chen R, Cohen SN, Nathan C. Correction: Improved Control of Tuberculosis and Activation of Macrophages in Mice Lacking Protein Kinase R. Plos One. 13: e0205424. PMID 30289942 DOI: 10.1371/Journal.Pone.0205424  0.323
2018 Negri A, Javidnia P, Mu R, Zhang X, Vendome J, Gold B, Roberts J, Barman D, Ioerger T, Sacchettini JC, Jiang X, Burns-Huang K, Warrier T, Ling Y, Warren JD, ... ... Nathan CF, et al. Identification of a Mycothiol-Dependent Nitroreductase from Mycobacterium tuberculosis. Acs Infectious Diseases. PMID 29465985 DOI: 10.1021/Acsinfecdis.7B00111  0.421
2018 Mundhra S, Bryk R, Hawryluk N, Zhang T, Jiang X, Nathan CF. Evidence for dispensability of protein kinase R in host control of tuberculosis. European Journal of Immunology. PMID 29436711 DOI: 10.1002/Eji.201747180  0.395
2017 Santos RLA, Bai L, Singh PK, Murakami N, Fan H, Zhan W, Zhu Y, Jiang X, Zhang K, Assker JP, Nathan CF, Li H, Azzi J, Lin G. Structure of human immunoproteasome with a reversible and noncompetitive inhibitor that selectively inhibits activated lymphocytes. Nature Communications. 8: 1692. PMID 29167449 DOI: 10.1038/S41467-017-01760-5  0.314
2017 Botella H, Yang G, Ouerfelli O, Ehrt S, Nathan CF, Vaubourgeix J. Distinct Spatiotemporal Dynamics of Peptidoglycan Synthesis between Mycobacterium smegmatis and Mycobacterium tuberculosis. Mbio. 8. PMID 28900018 DOI: 10.1128/Mbio.01183-17  0.376
2017 Nathan C. Kunkel Lecture: Fundamental immunodeficiency and its correction. The Journal of Experimental Medicine. PMID 28701368 DOI: 10.1084/Jem.20170637  0.307
2017 Saito K, Warrier T, Somersan-Karakaya S, Kaminski L, Mi J, Jiang X, Park S, Shigyo K, Gold B, Roberts J, Weber E, Jacobs WR, Nathan CF. Rifamycin action on RNA polymerase in antibiotic-tolerant Mycobacterium tuberculosis results in differentially detectable populations. Proceedings of the National Academy of Sciences of the United States of America. PMID 28559332 DOI: 10.1073/Pnas.1705385114  0.389
2017 Gold B, Nathan C. Targeting Phenotypically Tolerant Mycobacterium tuberculosis. Microbiology Spectrum. 5. PMID 28233509 DOI: 10.1128/Microbiolspec.Tbtb2-0031-2016  0.417
2017 Totaro KA, Barthelme D, Simpson PT, Jiang X, Lin G, Nathan CF, Sauer RT, Sello JK. Rational Design of Selective and Bioactive Inhibitors of the Mycobacterium tuberculosis Proteasome. Acs Infectious Diseases. 3: 176-181. PMID 28183185 DOI: 10.1021/Acsinfecdis.6B00172  0.415
2016 Gold B, Roberts J, Ling Y, Lopez Quezada L, Glasheen J, Ballinger E, Somersan-Karakaya S, Warrier T, Nathan C. Visualization of the Charcoal Agar Resazurin Assay for Semi-quantitative, Medium-throughput Enumeration of Mycobacteria. Journal of Visualized Experiments : Jove. PMID 28060290 DOI: 10.3791/54690  0.416
2016 Dartois V, Saito K, Warrier T, Nathan C. New Evidence for the Complexity of the Population Structure of Mycobacterium tuberculosis Increases the Diagnostic and Biologic Challenges. American Journal of Respiratory and Critical Care Medicine. 194: 1448-1451. PMID 27976945 DOI: 10.1164/Rccm.201607-1431Ed  0.301
2016 Hsu HC, Singh PK, Fan H, Wang R, Sukenick GD, Nathan CF, Lin G, Li H. Structural basis for the species-selective binding of N,C-capped dipeptides to the Mycobacterium tuberculosis proteasome. Biochemistry. PMID 27976853 DOI: 10.1021/Acs.Biochem.6B01107  0.364
2016 Sula Karreci E, Fan H, Uehara M, Mihali AB, Singh PK, Kurdi AT, Solhjou Z, Riella LV, Ghobrial I, Laragione T, Routray S, Assaker JP, Wang R, Sukenick G, Shi L, ... ... Nathan CF, et al. Brief treatment with a highly selective immunoproteasome inhibitor promotes long-term cardiac allograft acceptance in mice. Proceedings of the National Academy of Sciences of the United States of America. PMID 27956634 DOI: 10.1073/Pnas.1618548114  0.306
2016 Lupoli TJ, Fay A, Adura C, Glickman MS, Nathan CF. Reconstitution of a Mycobacterium tuberculosis proteostasis network highlights essential cofactor interactions with chaperone DnaK. Proceedings of the National Academy of Sciences of the United States of America. PMID 27872278 DOI: 10.1073/Pnas.1617644113  0.35
2016 Nathan C. Macrophages' Choice: Take It In or Keep It Out. Immunity. 45: 710-711. PMID 27760333 DOI: 10.1016/J.Immuni.2016.10.002  0.369
2016 Singh PK, Fan H, Jiang X, Shi L, Nathan CF, Lin G. Immunoproteasome β5i-Selective Dipeptidomimetic Inhibitors. Chemmedchem. PMID 27561172 DOI: 10.1002/Cmdc.201600384  0.312
2016 Van Voorhis WC, Adams JH, Adelfio R, Ahyong V, Akabas MH, Alano P, Alday A, Alemán Resto Y, Alsibaee A, Alzualde A, Andrews KT, Avery SV, Avery VM, Ayong L, Baker M, ... ... Nathan C, et al. Open Source Drug Discovery with the Malaria Box Compound Collection for Neglected Diseases and Beyond. Plos Pathogens. 12: e1005763. PMID 27467575 DOI: 10.1371/Journal.Ppat.1005763  0.317
2016 Warrier T, Kapilashrami K, Argyrou A, Ioerger TR, Little D, Murphy KC, Nandakumar M, Park S, Gold B, Mi J, Zhang T, Meiler E, Rees M, Somersan-Karakaya S, Porras-De Francisco E, ... ... Nathan CF, et al. N-methylation of a bactericidal compound as a resistance mechanism in Mycobacterium tuberculosis. Proceedings of the National Academy of Sciences of the United States of America. PMID 27432954 DOI: 10.1073/Pnas.1606590113  0.373
2016 Gold B, Smith R, Nguyen Q, Roberts J, Ling Y, Lopez Quezeda L, Somersan-Karakaya S, Warrier T, Little D, Pingle M, Zhang D, Ballinger E, Zimmerman M, Dartois V, Hanson PR, ... ... Nathan CF, et al. Novel cephalosporins selectively active on non-replicating Mycobacterium tuberculosis. Journal of Medicinal Chemistry. PMID 27144688 DOI: 10.1021/Acs.Jmedchem.5B01833  0.434
2015 Warrier T, Martinez-Hoyos M, Marin-Amieva M, Colmenarejo G, Porras-De Francisco E, Alvarez-Pedraglio AI, Fraile-Gabaldon MT, Torres-Gomez PA, Lopez-Quezada L, Gold B, Roberts J, Ling Y, Somersan-Karakaya S, Little D, Cammack N, ... Nathan C, et al. Identification of Novel Anti-mycobacterial Compounds by Screening a Pharmaceutical Small-Molecule Library against Nonreplicating Mycobacterium tuberculosis. Acs Infectious Diseases. 1: 580-585. PMID 27623055 DOI: 10.1021/Acsinfecdis.5B00025  0.354
2015 Maksymiuk C, Ioerger T, Balakrishnan A, Bryk R, Rhee K, Sacchettini J, Nathan C. Comparison of transposon and deletion mutants in Mycobacterium tuberculosis: The case of rv1248c, encoding 2-hydroxy-3-oxoadipate synthase. Tuberculosis (Edinburgh, Scotland). 95: 689-94. PMID 26547230 DOI: 10.1016/J.Tube.2015.08.009  0.347
2015 Maksymiuk C, Balakrishnan A, Bryk R, Rhee KY, Nathan CF. E1 of α-ketoglutarate dehydrogenase defends Mycobacterium tuberculosis against glutamate anaplerosis and nitroxidative stress. Proceedings of the National Academy of Sciences of the United States of America. 112: E5834-43. PMID 26430237 DOI: 10.1073/Pnas.1510932112  0.342
2015 Gold B, Roberts J, Ling Y, Quezada LL, Glasheen J, Ballinger E, Somersan-Karakaya S, Warrier T, Warren JD, Nathan C. Rapid, Semiquantitative Assay To Discriminate among Compounds with Activity against Replicating or Nonreplicating Mycobacterium tuberculosis. Antimicrobial Agents and Chemotherapy. 59: 6521-38. PMID 26239979 DOI: 10.1128/Aac.00803-15  0.383
2015 Zhao N, Sun M, Burns-Huang K, Jiang X, Ling Y, Darby C, Ehrt S, Liu G, Nathan C. Identification of Rv3852 as an Agrimophol-Binding Protein in Mycobacterium tuberculosis. Plos One. 10: e0126211. PMID 25978362 DOI: 10.1371/Journal.Pone.0126211  0.801
2015 Gold B, Warrier T, Nathan C. A multi-stress model for high throughput screening against non-replicating Mycobacterium tuberculosis. Methods in Molecular Biology (Clifton, N.J.). 1285: 293-315. PMID 25779324 DOI: 10.1007/978-1-4939-2450-9_18  0.406
2015 Nathan C, Barry CE. TB drug development: immunology at the table. Immunological Reviews. 264: 308-18. PMID 25703568 DOI: 10.1111/Imr.12275  0.39
2015 Vaubourgeix J, Lin G, Dhar N, Chenouard N, Jiang X, Botella H, Lupoli T, Mariani O, Yang G, Ouerfelli O, Unser M, Schnappinger D, McKinney J, Nathan C. Stressed mycobacteria use the chaperone ClpB to sequester irreversibly oxidized proteins asymmetrically within and between cells. Cell Host & Microbe. 17: 178-90. PMID 25620549 DOI: 10.1016/J.Chom.2014.12.008  0.377
2015 Zhao N, Darby CM, Small J, Bachovchin DA, Jiang X, Burns-Huang KE, Botella H, Ehrt S, Boger DL, Anderson ED, Cravatt BF, Speers AE, Fernandez-Vega V, Hodder PS, Eberhart C, ... ... Nathan CF, et al. Target-based screen against a periplasmic serine protease that regulates intrabacterial pH homeostasis in Mycobacterium tuberculosis. Acs Chemical Biology. 10: 364-71. PMID 25457457 DOI: 10.1021/Cb500746Z  0.787
2014 Nandakumar M, Nathan C, Rhee KY. Isocitrate lyase mediates broad antibiotic tolerance in Mycobacterium tuberculosis. Nature Communications. 5: 4306. PMID 24978671 DOI: 10.1038/Ncomms5306  0.429
2014 Zheng P, Somersan-Karakaya S, Lu S, Roberts J, Pingle M, Warrier T, Little D, Guo X, Brickner SJ, Nathan CF, Gold B, Liu G. Synthetic calanolides with bactericidal activity against replicating and nonreplicating Mycobacterium tuberculosis. Journal of Medicinal Chemistry. 57: 3755-72. PMID 24694175 DOI: 10.1021/Jm4019228  0.398
2014 Gong Y, Somersan Karakaya S, Guo X, Zheng P, Gold B, Ma Y, Little D, Roberts J, Warrier T, Jiang X, Pingle M, Nathan CF, Liu G. Benzimidazole-based compounds kill Mycobacterium tuberculosis. European Journal of Medicinal Chemistry. 75: 336-53. PMID 24556148 DOI: 10.1016/J.Ejmech.2014.01.039  0.375
2014 Nathan C. Drug-resistant tuberculosis: a new shot on goal. Nature Medicine. 20: 121-3. PMID 24504402 DOI: 10.1038/Nm.3470  0.371
2013 Bryk R, Arango N, Maksymiuk C, Balakrishnan A, Wu YT, Wong CH, Masquelin T, Hipskind P, Lima CD, Nathan C. Lipoamide channel-binding sulfonamides selectively inhibit mycobacterial lipoamide dehydrogenase. Biochemistry. 52: 9375-84. PMID 24251446 DOI: 10.1021/Bi401077F  0.34
2013 Rath P, Huang C, Wang T, Wang T, Li H, Prados-Rosales R, Elemento O, Casadevall A, Nathan CF. Genetic regulation of vesiculogenesis and immunomodulation in Mycobacterium tuberculosis. Proceedings of the National Academy of Sciences of the United States of America. 110: E4790-7. PMID 24248369 DOI: 10.1073/Pnas.1320118110  0.631
2013 Cunningham-Bussel A, Zhang T, Nathan CF. Nitrite produced by Mycobacterium tuberculosis in human macrophages in physiologic oxygen impacts bacterial ATP consumption and gene expression. Proceedings of the National Academy of Sciences of the United States of America. 110: E4256-65. PMID 24145454 DOI: 10.1073/Pnas.1316894110  0.814
2013 Cunningham-Bussel A, Bange FC, Nathan CF. Nitrite impacts the survival of Mycobacterium tuberculosis in response to isoniazid and hydrogen peroxide. Microbiologyopen. 2: 901-11. PMID 24019302 DOI: 10.1002/mbo3.126  0.8
2013 Darby CM, Ingólfsson HI, Jiang X, Shen C, Sun M, Zhao N, Burns K, Liu G, Ehrt S, Warren JD, Andersen OS, Anderson OS, Brickner SJ, Nathan C. Whole cell screen for inhibitors of pH homeostasis in Mycobacterium tuberculosis. Plos One. 8: e68942. PMID 23935911 DOI: 10.1371/Journal.Pone.0068942  0.81
2013 Lin G, Chidawanyika T, Tsu C, Warrier T, Vaubourgeix J, Blackburn C, Gigstad K, Sintchak M, Dick L, Nathan C. N,C-capped dipeptides with selectivity for mycobacterial proteasome over human proteasomes: Role of S3 and S1 binding pockets Journal of the American Chemical Society. 135: 9968-9971. PMID 23782398 DOI: 10.1021/Ja400021X  0.32
2013 Balakrishnan A, Jordan F, Nathan CF. Influence of allosteric regulators on individual steps in the reaction catalyzed by Mycobacterium tuberculosis 2-hydroxy-3-oxoadipate synthase. The Journal of Biological Chemistry. 288: 21688-702. PMID 23760263 DOI: 10.1074/Jbc.M113.465419  0.334
2013 Hou YJ, Banerjee R, Thomas B, Nathan C, García-Sastre A, Ding A, Uccellini MB. SARM is required for neuronal injury and cytokine production in response to central nervous system viral infection. Journal of Immunology (Baltimore, Md. : 1950). 191: 875-83. PMID 23749635 DOI: 10.4049/Jimmunol.1300374  0.329
2013 Nathan C, Cunningham-Bussel A. Beyond oxidative stress: an immunologist's guide to reactive oxygen species. Nature Reviews. Immunology. 13: 349-61. PMID 23618831 DOI: 10.1038/Nri3423  0.782
2013 Shigyo K, Ocheretina O, Merveille YM, Johnson WD, Pape JW, Nathan CF, Fitzgerald DW. Efficacy of nitazoxanide against clinical isolates of Mycobacterium tuberculosis. Antimicrobial Agents and Chemotherapy. 57: 2834-7. PMID 23507275 DOI: 10.1128/Aac.02542-12  0.338
2013 Darby CM, Ingólfsson HI, Jiang X, Shen C, Sun M, Zhao N, Burns K, Liu G, Ehrt S, Warren JD, Andersen OS, Brickner SJ, Nathan C. Correction: Whole Cell Screen for Inhibitors of pH Homeostasis in Mycobacterium tuberculosis Plos One. 8. DOI: 10.1371/Annotation/760B5B07-4922-42C4-B33A-162C1E9Ae188  0.796
2012 Gold B, Pingle M, Brickner SJ, Shah N, Roberts J, Rundell M, Bracken WC, Warrier T, Somersan S, Venugopal A, Darby C, Jiang X, Warren JD, Fernandez J, Ouerfelli O, ... ... Nathan CF, et al. Nonsteroidal anti-inflammatory drug sensitizes Mycobacterium tuberculosis to endogenous and exogenous antimicrobials. Proceedings of the National Academy of Sciences of the United States of America. 109: 16004-11. PMID 23012453 DOI: 10.1073/Pnas.1214188109  0.788
2012 Nathan C. Fresh approaches to anti-infective therapies. Science Translational Medicine. 4: 140sr2. PMID 22745440 DOI: 10.1126/Scitranslmed.3003081  0.319
2012 Nathan C. Secretory products of macrophages: twenty-five years on. The Journal of Clinical Investigation. 122: 1189-90. PMID 22570864 DOI: 10.1172/Jci62930  0.329
2012 Wu K, Koo J, Jiang X, Chen R, Cohen SN, Nathan C. Improved control of tuberculosis and activation of macrophages in mice lacking protein kinase R. Plos One. 7: e30512. PMID 22359543 DOI: 10.1371/Journal.Pone.0030512  0.451
2011 Banchereau J, Cohn F, Inaba K, Muller B, Mellman I, Nathan C, Nussenzweig M, O'Garra A, Seder B, Schuler G, Sher A. Remembering Ralph Steinman. The Journal of Experimental Medicine. 208: 2343-7. PMID 22216461 DOI: 10.1084/Jem.20112295  0.436
2011 de Carvalho LP, Darby CM, Rhee KY, Nathan C. Nitazoxanide Disrupts Membrane Potential and Intrabacterial pH Homeostasis of Mycobacterium tuberculosis. Acs Medicinal Chemistry Letters. 2: 849-854. PMID 22096616 DOI: 10.1021/Ml200157F  0.794
2011 Vogt G, Nathan C. In vitro differentiation of human macrophages with enhanced antimycobacterial activity. The Journal of Clinical Investigation. 121: 3889-901. PMID 21911939 DOI: 10.1172/Jci57235  0.42
2011 Darby CM, Venugopal A, Ehrt S, Nathan CF. Mycobacterium tuberculosis gene Rv2136c is dispensable for acid resistance and virulence in mice. Tuberculosis (Edinburgh, Scotland). 91: 343-7. PMID 21778115 DOI: 10.1016/J.Tube.2011.06.007  0.8
2011 Bryk R, Wu K, Raimundo BC, Boardman PE, Chao P, Conn GL, Anderson E, Cole JL, Duffy NP, Nathan C, Griffin JH. Identification of new inhibitors of protein kinase R guided by statistical modeling. Bioorganic & Medicinal Chemistry Letters. 21: 4108-14. PMID 21632247 DOI: 10.1016/J.Bmcl.2011.04.149  0.313
2011 Rhee KY, de Carvalho LP, Bryk R, Ehrt S, Marrero J, Park SW, Schnappinger D, Venugopal A, Nathan C. Central carbon metabolism in Mycobacterium tuberculosis: an unexpected frontier. Trends in Microbiology. 19: 307-14. PMID 21561773 DOI: 10.1016/J.Tim.2011.03.008  0.579
2011 Venugopal A, Bryk R, Shi S, Rhee K, Rath P, Schnappinger D, Ehrt S, Nathan C. Virulence of Mycobacterium tuberculosis depends on lipoamide dehydrogenase, a member of three multienzyme complexes. Cell Host & Microbe. 9: 21-31. PMID 21238944 DOI: 10.1016/J.Chom.2010.12.004  0.786
2011 Mazloum N, Stegman MA, Croteau DL, Van Houten B, Kwon NS, Ling Y, Dickinson C, Venugopal A, Towheed MA, Nathan C. Identification of a chemical that inhibits the mycobacterial UvrABC complex in nucleotide excision repair. Biochemistry. 50: 1329-35. PMID 21235228 DOI: 10.1021/Bi101674C  0.576
2010 Beaulieu AM, Rath P, Imhof M, Siddall ME, Roberts J, Schnappinger D, Nathan CF. Genome-wide screen for Mycobacterium tuberculosis genes that regulate host immunity. Plos One. 5: e15120. PMID 21170273 DOI: 10.1371/Journal.Pone.0015120  0.807
2010 Seimon TA, Kim MJ, Blumenthal A, Koo J, Ehrt S, Wainwright H, Bekker LG, Kaplan G, Nathan C, Tabas I, Russell DG. Induction of ER stress in macrophages of tuberculosis granulomas. Plos One. 5: e12772. PMID 20856677 DOI: 10.1371/Journal.Pone.0012772  0.385
2010 Lin G, Li D, Chidawanyika T, Nathan C, Li H. Fellutamide B is a potent inhibitor of the Mycobacterium tuberculosis proteasome. Archives of Biochemistry and Biophysics. 501: 214-20. PMID 20558127 DOI: 10.1016/J.Abb.2010.06.009  0.323
2010 Darby CM, Nathan CF. Killing of non-replicating Mycobacterium tuberculosis by 8-hydroxyquinoline. The Journal of Antimicrobial Chemotherapy. 65: 1424-7. PMID 20435781 DOI: 10.1093/Jac/Dkq145  0.797
2010 de Carvalho LP, Zhao H, Dickinson CE, Arango NM, Lima CD, Fischer SM, Ouerfelli O, Nathan C, Rhee KY. Activity-based metabolomic profiling of enzymatic function: identification of Rv1248c as a mycobacterial 2-hydroxy-3-oxoadipate synthase. Chemistry & Biology. 17: 323-32. PMID 20416504 DOI: 10.1016/J.Chembiol.2010.03.009  0.306
2010 Bryk R, Arango N, Venugopal A, Warren JD, Park YH, Patel MS, Lima CD, Nathan C. Triazaspirodimethoxybenzoyls as selective inhibitors of mycobacterial lipoamide dehydrogenase . Biochemistry. 49: 1616-27. PMID 20078138 DOI: 10.1021/Bi9016186  0.566
2010 Yin F, Banerjee R, Thomas B, Zhou P, Qian L, Jia T, Ma X, Ma Y, Iadecola C, Beal MF, Nathan C, Ding A. Exaggerated inflammation, impaired host defense, and neuropathology in progranulin-deficient mice. The Journal of Experimental Medicine. 207: 117-28. PMID 20026663 DOI: 10.1084/Jem.20091568  0.351
2009 Wang T, Li H, Lin G, Tang C, Li D, Nathan C, Darwin KH, Li H. Structural insights on the Mycobacterium tuberculosis proteasomal ATPase Mpa. Structure (London, England : 1993). 17: 1377-85. PMID 19836337 DOI: 10.1016/J.Str.2009.08.010  0.657
2009 Lin G, Li D, de Carvalho LP, Deng H, Tao H, Vogt G, Wu K, Schneider J, Chidawanyika T, Warren JD, Li H, Nathan C. Inhibitors selective for mycobacterial versus human proteasomes. Nature. 461: 621-6. PMID 19759536 DOI: 10.1038/Nature08357  0.396
2009 de Carvalho LP, Lin G, Jiang X, Nathan C. Nitazoxanide kills replicating and nonreplicating Mycobacterium tuberculosis and evades resistance. Journal of Medicinal Chemistry. 52: 5789-92. PMID 19736929 DOI: 10.1021/Jm9010719  0.379
2009 Vandal OH, Nathan CF, Ehrt S. Acid resistance in Mycobacterium tuberculosis. Journal of Bacteriology. 191: 4714-21. PMID 19465648 DOI: 10.1128/Jb.00305-09  0.809
2009 Nathan C. Taming tuberculosis: a challenge for science and society. Cell Host & Microbe. 5: 220-4. PMID 19286131 DOI: 10.1016/J.Chom.2009.02.004  0.332
2009 Lee WL, Gold B, Darby C, Brot N, Jiang X, de Carvalho LP, Wellner D, St John G, Jacobs WR, Nathan C. Mycobacterium tuberculosis expresses methionine sulphoxide reductases A and B that protect from killing by nitrite and hypochlorite. Molecular Microbiology. 71: 583-93. PMID 19040639 DOI: 10.1111/J.1365-2958.2008.06548.X  0.806
2009 Vandal OH, Roberts JA, Odaira T, Schnappinger D, Nathan CF, Ehrt S. Acid-susceptible mutants of Mycobacterium tuberculosis share hypersusceptibility to cell wall and oxidative stress and to the host environment. Journal of Bacteriology. 191: 625-31. PMID 19011036 DOI: 10.1128/Jb.00932-08  0.812
2008 Nathan C. Microbiology. An antibiotic mimics immunity. Science (New York, N.Y.). 322: 1337-8. PMID 19039126 DOI: 10.1126/Science.1167452  0.309
2008 Lin G, Tsu C, Dick L, Zhou XK, Nathan C. Distinct specificities of Mycobacterium tuberculosis and mammalian proteasomes for N-acetyl tripeptide substrates. The Journal of Biological Chemistry. 283: 34423-31. PMID 18829465 DOI: 10.1074/Jbc.M805324200  0.342
2008 Nathan C, Gold B, Lin G, Stegman M, de Carvalho LP, Vandal O, Venugopal A, Bryk R. A philosophy of anti-infectives as a guide in the search for new drugs for tuberculosis. Tuberculosis (Edinburgh, Scotland). 88: S25-33. PMID 18762150 DOI: 10.1016/S1472-9792(08)70034-9  0.798
2008 Gold B, Deng H, Bryk R, Vargas D, Eliezer D, Roberts J, Jiang X, Nathan C. Identification of a copper-binding metallothionein in pathogenic mycobacteria. Nature Chemical Biology. 4: 609-16. PMID 18724363 DOI: 10.1038/Nchembio.109  0.355
2008 Vandal OH, Pierini LM, Schnappinger D, Nathan CF, Ehrt S. A membrane protein preserves intrabacterial pH in intraphagosomal Mycobacterium tuberculosis. Nature Medicine. 14: 849-54. PMID 18641659 DOI: 10.1038/Nm.1795  0.804
2008 Bryk R, Gold B, Venugopal A, Singh J, Samy R, Pupek K, Cao H, Popescu C, Gurney M, Hotha S, Cherian J, Rhee K, Ly L, Converse PJ, Ehrt S, ... ... Nathan C, et al. Selective killing of nonreplicating mycobacteria. Cell Host & Microbe. 3: 137-45. PMID 18329613 DOI: 10.1016/J.Chom.2008.02.003  0.815
2007 Kim Y, Zhou P, Qian L, Chuang JZ, Lee J, Li C, Iadecola C, Nathan C, Ding A. MyD88-5 links mitochondria, microtubules, and JNK3 in neurons and regulates neuronal survival. The Journal of Experimental Medicine. 204: 2063-74. PMID 17724133 DOI: 10.1084/Jem.20070868  0.308
2006 Nathan C. Neutrophils and immunity: challenges and opportunities. Nature Reviews. Immunology. 6: 173-82. PMID 16498448 DOI: 10.1038/Nri1785  0.315
2006 Vandal OH, Gelb MH, Ehrt S, Nathan CF. Cytosolic phospholipase A2 enzymes are not required by mouse bone marrow-derived macrophages for the control of Mycobacterium tuberculosis in vitro. Infection and Immunity. 74: 1751-6. PMID 16495548 DOI: 10.1128/Iai.74.3.1751-1756.2006  0.812
2006 Hu G, Lin G, Wang M, Dick L, Xu RM, Nathan C, Li H. Structure of the Mycobacterium tuberculosis proteasome and mechanism of inhibition by a peptidyl boronate. Molecular Microbiology. 59: 1417-28. PMID 16468986 DOI: 10.1111/J.1365-2958.2005.05036.X  0.329
2006 Lin G, Hu G, Tsu C, Kunes YZ, Li H, Dick L, Parsons T, Li P, Chen Z, Zwickl P, Weich N, Nathan C. Mycobacterium tuberculosis prcBA genes encode a gated proteasome with broad oligopeptide specificity. Molecular Microbiology. 59: 1405-16. PMID 16468985 DOI: 10.1111/J.1365-2958.2005.05035.X  0.313
2006 Cohn EF, Nathan C, Radzioch D, Yu H, Xiang Z, Ding A. Abrupt expression of TLR4 in TLR4-deficient macrophages imposes a selective disadvantage: genetic evidence for TLR4-dependent responses to endogenous, nonmicrobial stimuli. Journal of Immunology (Baltimore, Md. : 1950). 176: 1185-94. PMID 16394008 DOI: 10.4049/Jimmunol.176.2.1185  0.339
2006 Han H, Roberts J, Lou O, Muller WA, Nathan N, Nathan C. Chemical inhibitors of TNF signal transduction in human neutrophils point to distinct steps in cell activation. Journal of Leukocyte Biology. 79: 147-54. PMID 16275893 DOI: 10.1189/Jlb.0605308  0.625
2005 Smith I, Nathan C, Peavy HH. Progress and new directions in genetics of tuberculosis: an NHLBI working group report. American Journal of Respiratory and Critical Care Medicine. 172: 1491-6. PMID 16192449 DOI: 10.1164/Rccm.200506-997Ws  0.373
2005 Rajashankar KR, Bryk R, Kniewel R, Buglino JA, Nathan CF, Lima CD. Crystal structure and functional analysis of lipoamide dehydrogenase from Mycobacterium tuberculosis. The Journal of Biological Chemistry. 280: 33977-83. PMID 16093239 DOI: 10.1074/Jbc.M507466200  0.346
2005 Tian J, Bryk R, Shi S, Erdjument-Bromage H, Tempst P, Nathan C. Mycobacterium tuberculosis appears to lack alpha-ketoglutarate dehydrogenase and encodes pyruvate dehydrogenase in widely separated genes. Molecular Microbiology. 57: 859-68. PMID 16045627 DOI: 10.1111/J.1365-2958.2005.04741.X  0.655
2005 Han H, Stessin A, Roberts J, Hess K, Gautam N, Kamenetsky M, Lou O, Hyde E, Nathan N, Muller WA, Buck J, Levin LR, Nathan C. Calcium-sensing soluble adenylyl cyclase mediates TNF signal transduction in human neutrophils. The Journal of Experimental Medicine. 202: 353-61. PMID 16043520 DOI: 10.1084/Jem.20050778  0.622
2005 Darwin KH, Nathan CF. Role for nucleotide excision repair in virulence of Mycobacterium tuberculosis. Infection and Immunity. 73: 4581-7. PMID 16040969 DOI: 10.1128/Iai.73.8.4581-4587.2005  0.675
2005 Tian J, Bryk R, Itoh M, Suematsu M, Nathan C. Variant tricarboxylic acid cycle in Mycobacterium tuberculosis: identification of alpha-ketoglutarate decarboxylase. Proceedings of the National Academy of Sciences of the United States of America. 102: 10670-5. PMID 16027371 DOI: 10.1073/Pnas.0501605102  0.487
2005 Kaufmann SH, Cole ST, Mizrahi V, Rubin E, Nathan C. Mycobacterium tuberculosis and the host response. The Journal of Experimental Medicine. 201: 1693-7. PMID 15939785 DOI: 10.1084/Jem.20050842  0.376
2005 Hisert KB, MacCoss M, Shiloh MU, Darwin KH, Singh S, Jones RA, Ehrt S, Zhang Z, Gaffney BL, Gandotra S, Holden DW, Murray D, Nathan C. A glutamate-alanine-leucine (EAL) domain protein of Salmonella controls bacterial survival in mice, antioxidant defence and killing of macrophages: role of cyclic diGMP. Molecular Microbiology. 56: 1234-45. PMID 15882417 DOI: 10.1111/J.1365-2958.2005.04632.X  0.785
2005 Darwin KH, Lin G, Chen Z, Li H, Nathan CF. Characterization of a Mycobacterium tuberculosis proteasomal ATPase homologue. Molecular Microbiology. 55: 561-71. PMID 15659170 DOI: 10.1111/J.1365-2958.2004.04403.X  0.678
2005 Rhee KY, Erdjument-Bromage H, Tempst P, Nathan CF. S-nitroso proteome of Mycobacterium tuberculosis: Enzymes of intermediary metabolism and antioxidant defense. Proceedings of the National Academy of Sciences of the United States of America. 102: 467-72. PMID 15626759 DOI: 10.1073/Pnas.0406133102  0.371
2004 Nathan C. The moving frontier in nitric oxide-dependent signaling. Science's Stke : Signal Transduction Knowledge Environment. 2004: pe52. PMID 15523044 DOI: 10.1126/Stke.2572004Pe52  0.326
2004 Hisert KB, Kirksey MA, Gomez JE, Sousa AO, Cox JS, Jacobs WR, Nathan CF, McKinney JD. Identification of Mycobacterium tuberculosis counterimmune (cim) mutants in immunodeficient mice by differential screening. Infection and Immunity. 72: 5315-21. PMID 15322028 DOI: 10.1128/Iai.72.9.5315-5321.2004  0.7
2003 Darwin KH, Ehrt S, Gutierrez-Ramos JC, Weich N, Nathan CF. The proteasome of Mycobacterium tuberculosis is required for resistance to nitric oxide. Science (New York, N.Y.). 302: 1963-6. PMID 14671303 DOI: 10.1126/Science.1091176  0.691
2003 Shi S, Nathan C, Schnappinger D, Drenkow J, Fuortes M, Block E, Ding A, Gingeras TR, Schoolnik G, Akira S, Takeda K, Ehrt S. MyD88 primes macrophages for full-scale activation by interferon-gamma yet mediates few responses to Mycobacterium tuberculosis. The Journal of Experimental Medicine. 198: 987-97. PMID 14517275 DOI: 10.1084/Jem.20030603  0.779
2003 Schnappinger D, Ehrt S, Voskuil MI, Liu Y, Mangan JA, Monahan IM, Dolganov G, Efron B, Butcher PD, Nathan C, Schoolnik GK. Transcriptional Adaptation of Mycobacterium tuberculosis within Macrophages: Insights into the Phagosomal Environment. The Journal of Experimental Medicine. 198: 693-704. PMID 12953091 DOI: 10.1084/Jem.20030846  0.431
2003 Nathan C. Immunology: Oxygen and the inflammatory cell. Nature. 422: 675-6. PMID 12700748 DOI: 10.1038/422675A  0.344
2003 Han H, Fuortes M, Nathan C. Critical role of the carboxyl terminus of proline-rich tyrosine kinase (Pyk2) in the activation of human neutrophils by tumor necrosis factor: separation of signals for the respiratory burst and degranulation. The Journal of Experimental Medicine. 197: 63-75. PMID 12515814 DOI: 10.1084/Jem.20021638  0.618
2002 Zhu J, Nathan C, Jin W, Sim D, Ashcroft GS, Wahl SM, Lacomis L, Erdjument-Bromage H, Tempst P, Wright CD, Ding A. Conversion of proepithelin to epithelins: roles of SLPI and elastase in host defense and wound repair. Cell. 111: 867-78. PMID 12526812 DOI: 10.1016/S0092-8674(02)01141-8  0.344
2002 Nathan C. Immunology. Catalytic antibody bridges innate and adaptive immunity. Science (New York, N.Y.). 298: 2143-4. PMID 12481124 DOI: 10.1126/Science.1080005  0.308
2002 Bryk R, Lima CD, Erdjument-Bromage H, Tempst P, Nathan C. Metabolic enzymes of mycobacteria linked to antioxidant defense by a thioredoxin-like protein Science. 295: 1073-1077. PMID 11799204 DOI: 10.1126/Science.1067798  0.373
2002 Weissbach H, Etienne F, Hoshi T, Heinemann SH, Lowther WT, Matthews B, St John G, Nathan C, Brot N. Peptide methionine sulfoxide reductase: structure, mechanism of action, and biological function. Archives of Biochemistry and Biophysics. 397: 172-8. PMID 11795868 DOI: 10.1006/Abbi.2001.2664  0.315
2001 Ehrt S, Schnappinger D, Bekiranov S, Drenkow J, Shi S, Gingeras TR, Gaasterland T, Schoolnik G, Nathan C. Reprogramming of the macrophage transcriptome in response to interferon-gamma and Mycobacterium tuberculosis: signaling roles of nitric oxide synthase-2 and phagocyte oxidase. The Journal of Experimental Medicine. 194: 1123-40. PMID 11602641 DOI: 10.1084/Jem.194.8.1123  0.64
2001 Hickman-Davis JM, Fang FC, Nathan C, Shepherd VL, Voelker DR, Wright JR. Lung surfactant and reactive oxygen-nitrogen species: Antimicrobial activity and host-pathogen interactions American Journal of Physiology - Lung Cellular and Molecular Physiology. 281. PMID 11504674 DOI: 10.1152/Ajplung.2001.281.3.L517  0.35
2001 St. John G, Brot N, Ruan J, Erdjument-Bromage H, Tempst P, Weissbach H, Nathan C. Peptide methionine sulfoxide reductase from Escherichia coli and Mycobacterium tuberculosis protects bacteria against oxidative damage from reactive nitrogen intermediates Proceedings of the National Academy of Sciences of the United States of America. 98: 9901-9906. PMID 11481433 DOI: 10.1073/Pnas.161295398  0.419
2001 Nathan C, Ding A. TREM-1: A new regulator of innate immunity in sepsis syndrome Nature Medicine. 7: 530-532. PMID 11329047 DOI: 10.1038/87846  0.309
2000 Bryk R, Griffin P, Nathan C. Peroxynitrite reductase activity of bacterial peroxiredoxins Nature. 407: 211-215. PMID 11001062 DOI: 10.1038/35025109  0.38
2000 Nathan C, Shiloh MU. Reactive oxygen and nitrogen intermediates in the relationship between mammalian hosts and microbial pathogens. Proceedings of the National Academy of Sciences of the United States of America. 97: 8841-8. PMID 10922044 DOI: 10.1073/Pnas.97.16.8841  0.735
2000 Grobmyer SR, Barie PS, Nathan CF, Fuortes M, Lin E, Lowry SF, Wright CD, Weyant MJ, Hydo L, Reeves F, Shiloh MU, Ding A. Secretory leukocyte protease inhibitor, an inhibitor of neutrophil activation, is elevated in serum in human sepsis and experimental endotoxemia. Critical Care Medicine. 28: 1276-82. PMID 10834665 DOI: 10.1097/00003246-200005000-00003  0.668
2000 Shiloh MU, Nathan CF. Reactive nitrogen intermediates and the pathogenesis of Salmonella and mycobacteria. Current Opinion in Microbiology. 3: 35-42. PMID 10679417 DOI: 10.1016/S1369-5274(99)00048-X  0.736
1999 Zhu J, Nathan C, Ding A. Suppression of macrophage responses to bacterial lipopolysaccharide by a non-secretory form of secretory leukocyte protease inhibitor Biochimica Et Biophysica Acta - Molecular Cell Research. 1451: 219-223. PMID 10556576 DOI: 10.1016/S0167-4889(99)00111-1  0.369
1999 Nicholson SC, Hahn RT, Grobmyer SR, Brause JE, Hafner A, Potter S, Devereux RB, Nathan CF. Echocardiographic and survival studies in mice undergoing endotoxic shock: effects of genetic ablation of inducible nitric oxide synthase and pharmacologic antagonism of platelet-activating factor. The Journal of Surgical Research. 86: 198-205. PMID 10534424 DOI: 10.1006/Jsre.1999.5715  0.327
1999 Fuortes M, Melchior M, Han H, Lyon GJ, Nathan C. Role of the tyrosine kinase pyk2 in the integrin-dependent activation of human neutrophils by TNF. The Journal of Clinical Investigation. 104: 327-35. PMID 10430614 DOI: 10.1172/Jci6018  0.594
1999 Ruan J, St John G, Ehrt S, Riley L, Nathan C. noxR3, a novel gene from Mycobacterium tuberculosis, protects Salmonella typhimurium from nitrosative and oxidative stress. Infection and Immunity. 67: 3276-83. PMID 10377101 DOI: 10.1128/Iai.67.7.3276-3283.1999  0.45
1999 Byrd CA, Bornmann W, Erdjument-Bromage H, Tempst P, Pavletich N, Rosen N, Nathan CF, Ding A. Heat shock protein 90 mediates macrophage activation by Taxol and bacterial lipopolysaccharide. Proceedings of the National Academy of Sciences of the United States of America. 96: 5645-50. PMID 10318938 DOI: 10.1073/Pnas.96.10.5645  0.334
1999 Nicholson SC, Grobmyer SR, Shiloh MU, Brause JE, Potter S, MacMicking JD, Dinauer MC, Nathan CF. Lethality of endotoxin in mice genetically deficient in the respiratory burst oxidase, inducible nitric oxide synthase, or both. Shock (Augusta, Ga.). 11: 253-8. PMID 10220301 DOI: 10.1097/00024382-199904000-00005  0.713
1999 Shiloh MU, MacMicking JD, Nicholson S, Brause JE, Potter S, Marino M, Fang F, Dinauer M, Nathan C. Phenotype of mice and macrophages deficient in both phagocyte oxidase and inducible nitric oxide synthase. Immunity. 10: 29-38. PMID 10023768 DOI: 10.1016/S1074-7613(00)80004-7  0.738
1999 Murray HW, Nathan CF. Macrophage microbicidal mechanisms in vivo: reactive nitrogen versus oxygen intermediates in the killing of intracellular visceral Leishmania donovani. The Journal of Experimental Medicine. 189: 741-6. PMID 9989990 DOI: 10.1084/Jem.189.4.741  0.361
1999 Ding A, Zhu J, Jin F, Grobmyer SR, Nathan CF. Anti-inflammatory function of secretory leukocyte protease inhibitor Journal of Endotoxin Research. 5: 167-169. DOI: 10.1177/09680519990050031201  0.351
1999 Grobmyer S, Barie P, Nathan C, Fuortes M, Lin E, Lowry S, Wright C, Wevant M, Hydo L, Reeves F, Shiloh M, Ding A. SECRETORY LEUKOCYTE PROTEASE INHIBITOR, AN INHIBITOR OF NEUTROPHIL ACTIVATION, IS ELEVATED IN SERUM IN HUMAN SEPSIS AND CORRELATES WITH SEVERITY OF ORGAN DYSFUNCTION Shock. 11: 45. DOI: 10.1097/00024382-199906001-00158  0.671
1999 Shiloh MU, Nathan CF. Antimicrobial mechanisms of macrophages Advances in Cellular and Molecular Biology of Membranes and Organelles. 5: 407-439. DOI: 10.1016/S1874-5172(99)80042-X  0.723
1998 Jin F, Nathan C, Ding A. Identification of genes involved in innate responsiveness to bacterial products by differential display Methods: a Companion to Methods in Enzymology. 16: 396-406. PMID 10049647 DOI: 10.1006/Meth.1998.0694  0.339
1998 Karupiah G, Chen JH, Mahalingam S, Nathan CF, MacMicking JD. Rapid interferon gamma-dependent clearance of influenza A virus and protection from consolidating pneumonitis in nitric oxide synthase 2-deficient mice. The Journal of Experimental Medicine. 188: 1541-6. PMID 9782132 DOI: 10.1084/Jem.188.8.1541  0.326
1998 Bonecini-Almeida MG, Silva JRLE, Kritski AL, Neves I, Morgado MG, Nathan C, Ho JL. Immune Response During HIV and Tuberculosis Co-infection Memorias Do Instituto Oswaldo Cruz. 93: 399-402. PMID 9698876 DOI: 10.1590/S0074-02761998000300023  0.321
1998 Karupiah G, Chen JH, Nathan CF, Mahalingam S, MacMicking JD. Identification of nitric oxide synthase 2 as an innate resistance locus against ectromelia virus infection. Journal of Virology. 72: 7703-6. PMID 9696880 DOI: 10.1128/Jvi.72.9.7703-7706.1998  0.386
1998 Chen L, Xie QW, Nathan C. Alkyl hydroperoxide reductase subunit C (AhpC) protects bacterial and human cells against reactive nitrogen intermediates Molecular Cell. 1: 795-805. PMID 9660963 DOI: 10.1016/S1097-2765(00)80079-9  0.411
1998 Jin F, Nathan CF, Radzioch D, Ding A. Lipopolysaccharide-related stimuli induce expression of the secretory leukocyte protease inhibitor, a macrophage-derived lipopolysaccharide inhibitor. Infection and Immunity. 66: 2447-52. PMID 9596701 DOI: 10.1128/Iai.66.6.2447-2452.1998  0.344
1998 Hierholzer C, Harbrecht B, Menezes JM, Kane J, MacMicking J, Nathan CF, Peitzman AB, Billiar TR, Tweardy DJ. Essential role of induced nitric oxide in the initiation of the inflammatory response after hemorrhagic shock. The Journal of Experimental Medicine. 187: 917-28. PMID 9500794 DOI: 10.1084/Jem.187.6.917  0.33
1997 De Groote MA, Ochsner UA, Shiloh MU, Nathan C, McCord JM, Dinauer MC, Libby SJ, Vazquez-Torres A, Xu Y, Fang FC. Periplasmic superoxide dismutase protects Salmonella from products of phagocyte NADPH-oxidase and nitric oxide synthase. Proceedings of the National Academy of Sciences of the United States of America. 94: 13997-4001. PMID 9391141 DOI: 10.1073/Pnas.94.25.13997  0.713
1997 Ehrt S, Shiloh MU, Ruan J, Choi M, Gunzburg S, Nathan C, Xie Q, Riley LW. A novel antioxidant gene from Mycobacterium tuberculosis. The Journal of Experimental Medicine. 186: 1885-96. PMID 9382887 DOI: 10.1084/Jem.186.11.1885  0.752
1997 Nathan C. Inducible nitric oxide synthase: What difference does it make? Journal of Clinical Investigation. 100: 2417-2423. PMID 9366554 DOI: 10.1172/Jci119782  0.307
1997 Hickey MJ, Sharkey KA, Sihota EG, Reinhardt PH, Macmicking JD, Nathan C, Kubes P. Inducible nitric oxide synthase-deficient mice have enhanced leukocyte-endothelium interactions in endotoxemia. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. 11: 955-64. PMID 9337148 DOI: 10.1096/Fasebj.11.12.9337148  0.345
1997 Shiloh MU, Ruan J, Nathan C. Evaluation of bacterial survival and phagocyte function with a fluorescence-based microplate assay. Infection and Immunity. 65: 3193-8. PMID 9234774 DOI: 10.1128/Iai.65.8.3193-3198.1997  0.714
1997 MacMicking JD, North RJ, LaCourse R, Mudgett JS, Shah SK, Nathan CF. Identification of nitric oxide synthase as a protective locus against tuberculosis. Proceedings of the National Academy of Sciences of the United States of America. 94: 5243-8. PMID 9144222 DOI: 10.1073/Pnas.94.10.5243  0.443
1997 MacMicking J, Xie QW, Nathan C. Nitric oxide and macrophage function Annual Review of Immunology. 15: 323-350. PMID 9143691 DOI: 10.1146/Annurev.Immunol.15.1.323  0.437
1997 Jin FY, Nathan C, Radzioch D, Ding A. Secretory leukocyte protease inhibitor: A macrophage product induced by and antagonistic to bacterial lipopolysaccharide Cell. 88: 417-426. PMID 9039268 DOI: 10.1016/S0092-8674(00)81880-2  0.337
1997 Wheeler MA, Smith SD, García-Cardeña G, Nathan CF, Weiss RM, Sessa WC. Bacterial infection induces nitric oxide synthase in human neutrophils. The Journal of Clinical Investigation. 99: 110-6. PMID 9011564 DOI: 10.1172/Jci119121  0.365
1996 Nicholson S, Bonecini-Almeida Mda G, Lapa e Silva JR, Nathan C, Xie QW, Mumford R, Weidner JR, Calaycay J, Geng J, Boechat N, Linhares C, Rom W, Ho JL. Inducible nitric oxide synthase in pulmonary alveolar macrophages from patients with tuberculosis. The Journal of Experimental Medicine. 183: 2293-302. PMID 8642338 DOI: 10.1084/Jem.183.5.2293  0.44
1996 Fuortes M, Jin WW, Nathan C. Ceramide selectively inhibits early events in the response of human neutrophils to tumor necrosis factor Journal of Leukocyte Biology. 59: 451-460. PMID 8604026 DOI: 10.1002/Jlb.59.3.451  0.306
1996 Cho HJ, Martin E, Xie QW, Sassa S, Nathan C. Inducible nitric oxide synthase: identification of amino acid residues essential for dimerization and binding of tetrahydrobiopterin. Proceedings of the National Academy of Sciences of the United States of America. 92: 11514-8. PMID 8524794 DOI: 10.1073/Pnas.92.25.11514  0.303
1995 Nathan C. Natural resistance and nitric oxide Cell. 82: 873-876. PMID 7553846 DOI: 10.1016/0092-8674(95)90019-5  0.314
1995 Maciejewski JP, Selleri C, Sato T, Cho HJ, Keefer LK, Nathan CF, Young NS. Nitric oxide suppression of human hematopoiesis in vitro. Contribution to inhibitory action of interferon-gamma and tumor necrosis factor-alpha. The Journal of Clinical Investigation. 96: 1085-92. PMID 7543491 DOI: 10.1172/Jci118094  0.333
1995 Nathan C. Inducible nitric oxide synthase: Regulation subserves function Current Topics in Microbiology and Immunology. 196: 1-4. PMID 7543397 DOI: 10.1007/978-3-642-79130-7_1  0.304
1995 MacMicking JD, Nathan C, Hom G, Chartrain N, Fletcher DS, Trumbauer M, Stevens K, Xie QW, Sokol K, Hutchinson N. Altered responses to bacterial infection and endotoxic shock in mice lacking inducible nitric oxide synthase. Cell. 81: 641-50. PMID 7538909 DOI: 10.1016/0092-8674(95)90085-3  0.343
1994 Celada A, Nathan C. Macrophage activation revisited Immunology Today. 15: 100-102. PMID 7909663 DOI: 10.1016/0167-5699(94)90150-3  0.314
1994 Sparrow JR, Nathan C, Vodovotz Y. Cytokine regulation of nitric oxide synthase in mouse retinal pigment epithelial cells in culture Experimental Eye Research. 59: 129-139. PMID 7530664 DOI: 10.1006/Exer.1994.1091  0.351
1994 Xie QW, Nathan C. The high-output nitric oxide pathway: Role and regulation Journal of Leukocyte Biology. 56: 576-582. PMID 7525816 DOI: 10.1002/Jlb.56.5.576  0.352
1994 Nathan C, Xie Qw. Nitric oxide synthases: Roles, tolls, and controls Cell. 78: 915-918. PMID 7522969 DOI: 10.1016/0092-8674(94)90266-6  0.309
1994 Martin E, Nathan C, Xie QW. Role of interferon regulatory factor 1 in induction of nitric oxide synthase Journal of Experimental Medicine. 180: 977-984. PMID 7520478 DOI: 10.1084/Jem.180.3.977  0.348
1994 Bogdan C, Vodovotz Y, Paik J, Xie QW, Nathan C. Mechanism of suppression of nitric oxide synthase expression by interleukin-4 in primary mouse macrophages. Journal of Leukocyte Biology. 55: 227-33. PMID 7507968 DOI: 10.1002/Jlb.55.2.227  0.367
1993 Klebanoff SJ, Nathan CF. Nitrite production by stimulated human polymorphonuclear leukocytes supplemented with azide and catalase Biochemical and Biophysical Research Communications. 197: 192-196. PMID 8250925 DOI: 10.1006/Bbrc.1993.2459  0.317
1993 Karupiah G, Xie QW, Buller RM, Nathan C, Duarte C, MacMicking JD. Inhibition of viral replication by interferon-gamma-induced nitric oxide synthase. Science (New York, N.Y.). 261: 1445-8. PMID 7690156 DOI: 10.1126/Science.7690156  0.368
1993 McCartney-Francis N, Allen JB, Mizel DE, Albina JE, Xie QW, Nathan CF, Wahl SM. Suppression of arthritis by an inhibitor of nitric oxide synthase. The Journal of Experimental Medicine. 178: 749-54. PMID 7688035 DOI: 10.1084/Jem.178.2.749  0.345
1993 Xie QW, Whisnant R, Nathan C. Promoter of the mouse gene encoding calcium-independent nitric oxide synthase confers inducibility by interferon γ and bacterial lipopolysaccharide Journal of Experimental Medicine. 177: 1779-1784. PMID 7684434 DOI: 10.1084/Jem.177.6.1779  0.354
1992 Nathan C. Nitric oxide as a secretory product of mammalian cells Faseb Journal. 6: 3051-3064. PMID 1381691 DOI: 10.1096/Fasebj.6.12.1381691  0.316
1992 Cho HJ, Xie QW, Calaycay J, Mumford RA, Swiderek KM, Lee TD, Nathan C. Calmodulin is a subunit of nitric oxide synthase from macrophages. The Journal of Experimental Medicine. 176: 599-604. PMID 1380065 DOI: 10.1084/Jem.176.2.599  0.324
1992 Xie QW, Cho HJ, Calaycay J, Mumford RA, Swiderek KM, Lee TD, Ding A, Troso T, Nathan C. Cloning and characterization of inducible nitric oxide synthase from mouse macrophages. Science (New York, N.Y.). 256: 225-8. PMID 1373522 DOI: 10.1126/Science.1373522  0.403
1991 Nathan C. A commentary: inducible nitric oxide synthase Research in Immunology. 142: 600-602. PMID 1725935 DOI: 10.1016/0923-2494(91)90117-2  0.308
1991 Kwon NS, Stuehr DJ, Nathan CF. Inhibition of tumor cell ribonucleotide reductase by macrophage-derived nitric oxide Journal of Experimental Medicine. 174: 761-767. PMID 1717630 DOI: 10.1084/Jem.174.4.761  0.37
1991 Stuehr DJ, Cho HJ, Kwon NS, Weise MF, Nathan CF. Purification and characterization of the cytokine-induced macrophage nitric oxide synthase: an FAD- and FMN-containing flavoprotein. Proceedings of the National Academy of Sciences of the United States of America. 88: 7773-7. PMID 1715579 DOI: 10.1073/Pnas.88.17.7773  0.365
1991 Nathan CF, Hibbs JB. Role of nitric oxide synthesis in macrophage antimicrobial activity. Current Opinion in Immunology. 3: 65-70. PMID 1711326 DOI: 10.1016/0952-7915(91)90079-G  0.391
1991 Stuehr DJ, Fasehun OA, Kwon NS, Gross SS, Gonzalez JA, Levi R, Nathan CF. Inhibition of macrophage and endothelial cell nitric oxide synthase by diphenyleneiodonium and its analogs. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. 5: 98-103. PMID 1703974 DOI: 10.1096/Fasebj.5.1.1703974  0.382
1990 Porteu F, Nathan C. Shedding of tumor necrosis factor receptors by activated human neutrophils Journal of Experimental Medicine. 172: 599-607. PMID 2165128 DOI: 10.1084/Jem.172.2.599  0.304
1990 Srimal S, Nathan C. Purification of macrophage deactivating factor Journal of Experimental Medicine. 171: 1347-1361. PMID 2109038 DOI: 10.1084/Jem.171.4.1347  0.323
1990 Stuehr DJ, Kwon NS, Nathan CF. FAD and GSH participate in macrophage synthesis of nitric oxide Biochemical and Biophysical Research Communications. 168: 558-565. PMID 1692211 DOI: 10.1016/0006-291X(90)92357-6  0.355
1990 Nathan CF, Stuehr DJ. Does endothelium-derived nitric oxide have a rolein cytokine-induced hypotension? Journal of the National Cancer Institute. 82: 726-728. PMID 1691302 DOI: 10.1093/Jnci/82.9.726  0.317
1989 Stuehr DJ, Gross SS, Sakuma I, Levi R, Nathan CF. Activated murine macrophages secrete a metabolite of arginine with the bioactivity of endothelium-derived relaxing factor and the chemical reactivity of nitric oxide. The Journal of Experimental Medicine. 169: 1011-20. PMID 2784476 DOI: 10.1084/Jem.169.3.1011  0.384
1989 Stuehr DJ, Kwon NS, Gross SS, Thiel BA, Levi R, Nathan CF. Synthesis of nitrogen oxides from L-arginine by macrophage cytosol: requirement for inducible and constitutive components. Biochemical and Biophysical Research Communications. 161: 420-6. PMID 2735902 DOI: 10.1016/0006-291X(89)92615-6  0.399
1989 Gabay JE, Scott RW, Campanelli D, Griffith J, Wilde C, Marra MN, Seeger M, Nathan CF. Antibiotic proteins of human polymorphonuclear leukocytes. Proceedings of the National Academy of Sciences of the United States of America. 86: 5610-4. PMID 2501794 DOI: 10.1073/Pnas.86.14.5610  0.301
1989 Stuehr DJ, Nathan CF. Nitric oxide: A macrophage product responsible for cytostasis and respiratory inhibition in tumor target cells Journal of Experimental Medicine. 169: 1543-1555. PMID 2497225 DOI: 10.1084/Jem.169.5.1543  0.339
1988 Wolpe SD, Davatelis G, Sherry B, Beutler B, Hesse DG, Nguyen HT, Moldawer LL, Nathan CF, Lowry SF, Cerami A. Macrophages secrete a novel heparin-binding protein with inflammatory and neutrophil chemokinetic properties. The Journal of Experimental Medicine. 167: 570-81. PMID 3279154 DOI: 10.1084/Jem.167.2.570  0.365
1988 Sakuma I, Stuehr DJ, Gross SS, Nathan C, Levi R. Identification of arginine as a precursor of endothelium-derived relaxing factor Proceedings of the National Academy of Sciences of the United States of America. 85: 8664-8667. PMID 3263652 DOI: 10.1073/Pnas.85.22.8664  0.302
1988 Murray HW, Nathan CF. In vivo killing of intracellular visceral leishmania donovani by a macrophage-targeted hydrogen peroxide-generating system Journal of Infectious Diseases. 158: 1372-1375. PMID 3198943 DOI: 10.1093/Infdis/158.6.1372  0.317
1988 Ding A, Nathan C. Analysis of the nonfunctional respiratory burst in murine Kupffer cells Journal of Experimental Medicine. 167: 1154-1170. PMID 3127523 DOI: 10.1084/Jem.167.3.1154  0.346
1988 Tsunawaki S, Sporn M, Ding A, Nathan C. Deactivation of macrophages by transforming growth factor-β Nature. 334: 260-262. PMID 3041283 DOI: 10.1038/334260A0  0.342
1987 Ding A, Wright SD, Nathan C. Activation of mouse peritoneal macrophages by monoclonal antibodies to Mac-1 (complement receptor type 3) Journal of Experimental Medicine. 165: 733-749. PMID 3102677 DOI: 10.1084/Jem.165.3.733  0.35
1987 O'Donnell-Tormey J, Nathan CF, Lanks K, DeBoer CJ, de la Harpe J. Secretion of pyruvate. An antioxidant defense of mammalian cells. The Journal of Experimental Medicine. 165: 500-14. PMID 3102672 DOI: 10.1084/Jem.165.2.500  0.342
1987 Nathan CF. Neutrophil activation on biological surfaces. Massive secretion of hydrogen peroxide in response to products of macrophages and lymphocytes Journal of Clinical Investigation. 80: 1550-1560. PMID 2445780 DOI: 10.1172/Jci113241  0.319
1987 Fels AO, Nathan CF, Cohn ZA. Hydrogen peroxide release by alveolar macrophages from sarcoid patients and by alveolar macrophages from normals after exposure to recombinant interferons alpha A, beta, and gamma and 1,25-dihydroxyvitamin D3. The Journal of Clinical Investigation. 80: 381-6. PMID 2440910 DOI: 10.1172/Jci113083  0.544
1986 Gabay JE, Heiple JM, Cohn ZA, Nathan CF. Subcellular location and properties of bactericidal factors from human neutrophils. The Journal of Experimental Medicine. 164: 1407-21. PMID 3772295 DOI: 10.1084/Jem.164.5.1407  0.542
1986 Nathan CF. Macrophage activation: some questions Annales De L"Institut Pasteur. Immunologie. 137: 345-351. PMID 3090928 DOI: 10.1016/S0771-050X(86)80051-1  0.331
1986 Nathan CF, Tsunawaki S. Secretion of toxic oxygen products by macrophages: regulatory cytokines and their effects on the oxidase Ciba Foundation Symposium. 118: 211-230. PMID 3089712  0.311
1986 Nathan CF, Kaplan G, Levis WR, Nusrat A, Witmer MD, Sherwin SA, Job CK, Horowitz CR, Steinman RM, Cohn ZA. Local and systemic effects of intradermal recombinant interferon-gamma in patients with lepromatous leprosy. The New England Journal of Medicine. 315: 6-15. PMID 3086725 DOI: 10.1056/Nejm198607033150102  0.641
1986 Tsunawaki S, Nathan CF. Macrophage deactivation. Altered kinetic properties of superoxide-producing enzyme after exposure to tumor cell-conditioned medium Journal of Experimental Medicine. 164: 1319-1331. PMID 3020151 DOI: 10.1084/Jem.164.4.1319  0.376
1986 Montgomery RR, Nathan CF, Cohn ZA. Effects of reagent and cell-generated hydrogen peroxide on the properties of low density lipoprotein. Proceedings of the National Academy of Sciences of the United States of America. 83: 6631-5. PMID 3018740 DOI: 10.1073/Pnas.83.17.6631  0.554
1986 Young JD, Nathan CF, Podack ER, Palladino MA, Cohn ZA. Functional channel formation associated with cytotoxic T-cell granules. Proceedings of the National Academy of Sciences of the United States of America. 83: 150-4. PMID 2417234 DOI: 10.1073/Pnas.83.1.150  0.501
1985 Lepay DA, Steinman RM, Nathan CF, Murray HW, Cohn ZA. Liver macrophages in murine listeriosis. Cell-mediated immunity is correlated with an influx of macrophages capable of generating reactive oxygen intermediates. The Journal of Experimental Medicine. 161: 1503-12. PMID 4009118 DOI: 10.1084/Jem.161.6.1503  0.659
1985 De la Harpe J, Nathan CF. A semi-automated micro-assay for H2O2 release by human blood monocytes and mouse peritoneal macrophages Journal of Immunological Methods. 78: 323-336. PMID 3989315 DOI: 10.1016/0022-1759(85)90089-4  0.334
1985 Nathan CF, Horowitz CR, de La Harpe J, Vadhan-Raj S, Sherwin SA, Oettgen HF, Krown SE. Administration of recombinant interferon γ to cancer patients enhances monocyte secretion of hydrogen peroxide Proceedings of the National Academy of Sciences of the United States of America. 82: 8686-8690. PMID 3936042 DOI: 10.1073/Pnas.82.24.8686  0.348
1985 Arrick BA, Griffo W, Cohn Z, Nathan C. Hydrogen peroxide from cellular metabolism of cystine: A requirement for lysis of murine tumor cells by vernolepin, a glutathione-depleting antineoplastic Journal of Clinical Investigation. 76: 567-574. PMID 3928682 DOI: 10.1172/Jci112008  0.778
1985 Lepay DA, Nathan CF, Steinman RM, Murray HW, Cohn ZA. Murine Kupffer cells. Mononuclear phagocytes deficient in the generation of reactive oxygen intermediates. The Journal of Experimental Medicine. 161: 1079-96. PMID 3921651 DOI: 10.1084/Jem.161.5.1079  0.663
1985 O'Donnell-Tormey J, DeBoer CJ, Nathan CF. Resistance to human tumor cells in vitro to oxidative cytolysis Journal of Clinical Investigation. 76: 80-86. PMID 2991343 DOI: 10.1172/Jci111981  0.38
1985 Leijh PCJ, Nathan CF, Van den Barselaar MT, Van Furth R. Relationship between extracellular stimulation of intracellular killing and oxygen-dependent microbicidal systems of monocytes Infection and Immunity. 47: 502-507. PMID 2981774 DOI: 10.1128/Iai.47.2.502-507.1985  0.341
1984 Freedman VH, Gorrell TE, Nathan CF, Copeland CS, Silverstein SC. Bacillus Calmette-Guérin-activated murine macrophages kill syngeneic melanoma cells under strict anaerobic conditions. The Journal of Experimental Medicine. 160: 94-107. PMID 6736873 DOI: 10.1084/Jem.160.1.94  0.389
1984 Arrick BA, Nathan CF. Glutathione Metabolism as a Determinant of Therapeutic Efficacy: A Review Cancer Research. 44: 4224-4232. PMID 6380705  0.712
1984 Nathan CF, Prendergast TJ, Wiebe ME, Stanley ER, Platzer E, Remold HG, Welte K, Rubin BY, Murray HW. Activation of human macrophages. Comparison of other cytokines with interferon-γ Journal of Experimental Medicine. 160: 600-605. PMID 6206183 DOI: 10.1084/Jem.160.2.600  0.363
1983 Akira Nakagawara, Nathan CF. A simple method for counting adherent cells: Application to cultured human monocytes, Macrophages and multinucleated giant cells Journal of Immunological Methods. 56: 261-268. PMID 6827097 DOI: 10.1016/0022-1759(83)90418-0  0.309
1983 Nathan CF, Murray HW, Wiebe ME, Rubin BY. Identification of interferon-γ as the lymphokine that activates human macrophage oxidative metabolism and antimicrobial activity Journal of Experimental Medicine. 158: 670-689. PMID 6411853 DOI: 10.1084/Jem.158.3.670  0.384
1983 Arrick BA, Nathan CF, Cohn ZA. Inhibition of glutathione synthesis augments lysis of murine tumor cells by sulfhydryl-reactive antineoplastics. The Journal of Clinical Investigation. 71: 258-67. PMID 6401768 DOI: 10.1172/Jci110766  0.773
1983 Nathan CF. Mechanisms of macrophage antimicrobial activity Transactions of the Royal Society of Tropical Medicine and Hygiene. 77: 620-630. PMID 6362115 DOI: 10.1016/0035-9203(83)90190-6  0.344
1983 Adams DO, Nathan CF. Molecular mechanisms in tumor-cell killing by activated macrophages Immunology Today. 4: 166-170. DOI: 10.1016/0167-5699(83)90005-1  0.337
1982 Szuro-Sudol A, Nathan CF. Suppression of macrophage oxidative metabolism by products of malignant and nonmalignant cells Journal of Experimental Medicine. 156: 945-961. PMID 7153714 DOI: 10.1084/Jem.156.4.945  0.394
1982 Nakagawara A, DeSantis NM, Nogueira N, Nathan CF. Lymphokines enhance the capacity of human monocytes to secrete reactive oxygen intermediates Journal of Clinical Investigation. 70: 1042-1048. PMID 7130393 DOI: 10.1172/Jci110691  0.343
1982 Nathan CF, Klebanoff SJ. Augmentation of spontaneous macrophage-mediated cytolysis by eosinophil peroxidase Journal of Experimental Medicine. 155: 1291-1308. PMID 6802924 DOI: 10.1084/Jem.155.5.1291  0.353
1982 Arrick BA, Nathan CF, Griffith OW, Cohn ZA. Glutathione depletion sensitizes tumor cells to oxidative cytolysis Journal of Biological Chemistry. 257: 1231-1237. PMID 6799503  0.741
1981 Nathan CF, Cohn ZA. Antitumor effects of hydrogen peroxide in vivo Journal of Experimental Medicine. 154: 1539-1553. PMID 7299347 DOI: 10.1084/Jem.154.5.1539  0.527
1981 Nathan CF, Arrick BA, Murray HW, DeSantis NM, Cohn ZA. Tumor cell anti-oxidant defenses. Inhibition of the glutathione redox cycle enhances macrophage-mediated cytolysis Journal of Experimental Medicine. 153: 766-782. PMID 7252413 DOI: 10.1084/Jem.153.4.766  0.776
1981 Nakagawara A, Nathan CF, Cohn ZA. Hydrogen peroxide metabolism in human monocytes during differentiation in vitro Journal of Clinical Investigation. 68: 1243-1252. PMID 6271809 DOI: 10.1172/Jci110370  0.559
1980 Murray HW, Nathan CF, Cohn ZA. Macrophage oxygen-dependent antimicrobial activity. IV. Role of endogenous scavengers of oxygen intermediates Journal of Experimental Medicine. 152: 1610-1624. PMID 7452149 DOI: 10.1084/Jem.152.6.1610  0.606
1980 Nathan C, Cohn Z. Role of oxygen-dependent mechanism in antibody-induced lysis of tumor cells by activated macrophages Journal of Experimental Medicine. 152: 198-208. PMID 6995553 DOI: 10.1084/Jem.152.1.198  0.571
1980 Nathan C, Brukner L, Kaplan G, Unkeless J, Cohn Z. Role of activated macrophages in antibody-dependent lysis of tumor cells. The Journal of Experimental Medicine. 152: 183-97. PMID 6995552 DOI: 10.1084/Jem.152.1.183  0.565
1980 Nathan CF, Murray HW, Cohn ZA. The macrophage as an effector cell New England Journal of Medicine. 303: 622-626. PMID 6447249 DOI: 10.1056/Nejm198009113031106  0.539
1979 Murray HW, Juangbhanich CW, Nathan CF, Cohn ZA. Macrophage oxygen-dependent antimicrobial activity. II. The role of oxygen intermediates Journal of Experimental Medicine. 150: 950-964. PMID 512587 DOI: 10.1084/Jem.150.4.950  0.603
1979 Nathan C, Nogueira N, Juangbhanich C, Ellis J, Cohn Z. Activation of macrophages in vivo and in vitro. Correlation between hydrogen peroxide release and killing of Trypanosoma cruzi. Journal of Experimental Medicine. 149: 1056-1068. PMID 376774 DOI: 10.1084/Jem.149.5.1056  0.596
1979 Nathan CF, Brukner LH, Silverstein SC, Cohn ZA. Extracellular cytolysis by activated macrophages and granulocytes. I. Pharmacologic triggering of effector cells and the release of hydrogen peroxide Journal of Experimental Medicine. 149: 84-99. PMID 368287 DOI: 10.1084/Jem.149.1.84  0.578
1979 Nathan CF, Silverstein SC, Brukner LH, Cohn ZA. Extracellular cytolysis by activated macrophages and granulocytes. II. Hydrogen Peroxide as a mediator of cytotoxicity Journal of Experimental Medicine. 149: 100-113. PMID 216763 DOI: 10.1084/Jem.149.1.100  0.602
1977 Nathan CF, Root RK. Hydrogen peroxide release from mouse peritoneal macrophages. Dependence on sequential activation and triggering Journal of Experimental Medicine. 146: 1648-1662. PMID 925614 DOI: 10.1084/Jem.146.6.1648  0.374
1977 Nathan CF, Terry WD. Decreased phagocytosis by peritoneal macrophages from BCG-treated mice. Induction of the phagocytic defect in normal macrophages with BCG in vitro Cellular Immunology. 29: 295-311. PMID 324633 DOI: 10.1016/0008-8749(77)90324-0  0.379
1976 Nathan CF, Hill VM, Terry WD. Isolation of a subpopulation of adherent peritoneal cells with anti-tumour activity Nature. 260: 146-148. PMID 768773 DOI: 10.1038/260146A0  0.335
1975 Nathan CF, Terry WD. Differential stimulation of murine lymphoma growth in vitro by normal and BCG activated macrophages Journal of Experimental Medicine. 142: 887-902. PMID 170358 DOI: 10.1084/Jem.142.4.887  0.389
1973 Nathan CF, Remold HG, David JR. Characterization of a lymphocyte factor which alters macrophage functions Journal of Experimental Medicine. 137: 275-290. PMID 4119587 DOI: 10.1084/Jem.137.2.275  0.355
1971 Nathan CF, Karnovsky ML, David JR. Alterations of macrophage functions by mediators from lymphocytes Journal of Experimental Medicine. 133: 1356-1376. PMID 5576335 DOI: 10.1084/Jem.133.6.1356  0.352
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