Carl F. Nathan - Publications

Affiliations: 
Microbiology and Immunology Weill Cornell Medical College, New York, NY, United States 
Area:
Immunology, Microbiology Biology
Website:
https://gradschool.weill.cornell.edu/faculty/carl-nathan

206 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2019 Wu J, Mu R, Sun M, Zhao N, Pan M, Li H, Dong Y, Sun Z, Bai J, Hu M, Nathan CF, Javid B, Liu G. Derivatives of Natural Product Agrimophol as Disruptors of Intrabacterial pH Homeostasis in Mycobacterium tuberculosis. Acs Infectious Diseases. PMID 31016962 DOI: 10.1021/acsinfecdis.8b00325  0.6
2018 Early J, Ollinger J, Darby C, Alling T, Mullen S, Casey A, Gold B, Ochoada J, Wiernicki T, Masquelin T, Nathan CF, Hipskind P, Parish T. Identification of compounds with pH-dependent bactericidal activity against Mycobacterium tuberculosis. Acs Infectious Diseases. PMID 30501173 DOI: 10.1021/acsinfecdis.8b00256  0.32
2018 Yu H, Lupoli TJ, Kovach A, Meng X, Zhao G, Nathan CF, Li H. ATP hydrolysis-coupled peptide translocation mechanism of ClpB. Proceedings of the National Academy of Sciences of the United States of America. PMID 30257943 DOI: 10.1073/pnas.1810648115  0.6
2018 Kirkman LA, Zhan W, Visone J, Dziedziech A, Singh PK, Fan H, Tong X, Bruzual I, Hara R, Kawasaki M, Imaeda T, Okamoto R, Sato K, Michino M, Alvaro EF, ... ... Nathan CF, et al. Antimalarial proteasome inhibitor reveals collateral sensitivity from intersubunit interactions and fitness cost of resistance. Proceedings of the National Academy of Sciences of the United States of America. PMID 29967165 DOI: 10.1073/pnas.1806109115  0.6
2018 Negri A, Javidnia P, Mu R, Zhang X, Vendome J, Gold B, Roberts J, Barman D, Ioerger T, Sacchettini JC, Jiang X, Burns-Huang K, Warrier T, Ling Y, Warren JD, ... ... Nathan CF, et al. Identification of a Mycothiol-Dependent Nitroreductase from Mycobacterium tuberculosis. Acs Infectious Diseases. PMID 29465985 DOI: 10.1021/acsinfecdis.7b00111  0.6
2017 Santos RLA, Bai L, Singh PK, Murakami N, Fan H, Zhan W, Zhu Y, Jiang X, Zhang K, Assker JP, Nathan CF, Li H, Azzi J, Lin G. Structure of human immunoproteasome with a reversible and noncompetitive inhibitor that selectively inhibits activated lymphocytes. Nature Communications. 8: 1692. PMID 29167449 DOI: 10.1038/s41467-017-01760-5  0.6
2017 Botella H, Yang G, Ouerfelli O, Ehrt S, Nathan CF, Vaubourgeix J. Distinct Spatiotemporal Dynamics of Peptidoglycan Synthesis between Mycobacterium smegmatis and Mycobacterium tuberculosis. Mbio. 8. PMID 28900018 DOI: 10.1128/mBio.01183-17  0.64
2017 Saito K, Warrier T, Somersan-Karakaya S, Kaminski L, Mi J, Jiang X, Park S, Shigyo K, Gold B, Roberts J, Weber E, Jacobs WR, Nathan CF. Rifamycin action on RNA polymerase in antibiotic-tolerant Mycobacterium tuberculosis results in differentially detectable populations. Proceedings of the National Academy of Sciences of the United States of America. PMID 28559332 DOI: 10.1073/pnas.1705385114  0.48
2017 Gold B, Nathan C. Targeting Phenotypically Tolerant Mycobacterium tuberculosis. Microbiology Spectrum. 5. PMID 28233509 DOI: 10.1128/microbiolspec.TBTB2-0031-2016  0.32
2017 Totaro KA, Barthelme D, Simpson PT, Jiang X, Lin G, Nathan CF, Sauer RT, Sello JK. Rational Design of Selective and Bioactive Inhibitors of the Mycobacterium tuberculosis Proteasome. Acs Infectious Diseases. 3: 176-181. PMID 28183185 DOI: 10.1021/acsinfecdis.6b00172  0.6
2016 Gold B, Roberts J, Ling Y, Lopez Quezada L, Glasheen J, Ballinger E, Somersan-Karakaya S, Warrier T, Nathan C. Visualization of the Charcoal Agar Resazurin Assay for Semi-quantitative, Medium-throughput Enumeration of Mycobacteria. Journal of Visualized Experiments : Jove. PMID 28060290 DOI: 10.3791/54690  0.48
2016 Hsu HC, Singh PK, Fan H, Wang R, Sukenick GD, Nathan CF, Lin G, Li H. Structural basis for the species-selective binding of N,C-capped dipeptides to the Mycobacterium tuberculosis proteasome. Biochemistry. PMID 27976853 DOI: 10.1021/acs.biochem.6b01107  0.6
2016 Sula Karreci E, Fan H, Uehara M, Mihali AB, Singh PK, Kurdi AT, Solhjou Z, Riella LV, Ghobrial I, Laragione T, Routray S, Assaker JP, Wang R, Sukenick G, Shi L, ... ... Nathan CF, et al. Brief treatment with a highly selective immunoproteasome inhibitor promotes long-term cardiac allograft acceptance in mice. Proceedings of the National Academy of Sciences of the United States of America. PMID 27956634 DOI: 10.1073/pnas.1618548114  0.6
2016 Singh PK, Fan H, Jiang X, Shi L, Nathan CF, Lin G. Immunoproteasome β5i-Selective Dipeptidomimetic Inhibitors. Chemmedchem. PMID 27561172 DOI: 10.1002/cmdc.201600384  0.6
2016 Van Voorhis WC, Adams JH, Adelfio R, Ahyong V, Akabas MH, Alano P, Alday A, Alemán Resto Y, Alsibaee A, Alzualde A, Andrews KT, Avery SV, Avery VM, Ayong L, Baker M, ... ... Nathan C, et al. Open Source Drug Discovery with the Malaria Box Compound Collection for Neglected Diseases and Beyond. Plos Pathogens. 12: e1005763. PMID 27467575 DOI: 10.1371/journal.ppat.1005763  0.32
2016 Warrier T, Kapilashrami K, Argyrou A, Ioerger TR, Little D, Murphy KC, Nandakumar M, Park S, Gold B, Mi J, Zhang T, Meiler E, Rees M, Somersan-Karakaya S, Porras-De Francisco E, ... ... Nathan CF, et al. N-methylation of a bactericidal compound as a resistance mechanism in Mycobacterium tuberculosis. Proceedings of the National Academy of Sciences of the United States of America. PMID 27432954 DOI: 10.1073/pnas.1606590113  1
2016 Gold B, Smith R, Nguyen Q, Roberts J, Ling Y, Lopez Quezeda L, Somersan-Karakaya S, Warrier T, Little D, Pingle M, Zhang D, Ballinger E, Zimmerman M, Dartois V, Hanson PR, ... ... Nathan CF, et al. Novel cephalosporins selectively active on non-replicating Mycobacterium tuberculosis. Journal of Medicinal Chemistry. PMID 27144688 DOI: 10.1021/acs.jmedchem.5b01833  1
2015 Warrier T, Martinez-Hoyos M, Marin-Amieva M, Colmenarejo G, Porras-De Francisco E, Alvarez-Pedraglio AI, Fraile-Gabaldon MT, Torres-Gomez PA, Lopez-Quezada L, Gold B, Roberts J, Ling Y, Somersan-Karakaya S, Little D, Cammack N, ... Nathan C, et al. Identification of Novel Anti-mycobacterial Compounds by Screening a Pharmaceutical Small-Molecule Library against Nonreplicating Mycobacterium tuberculosis. Acs Infectious Diseases. 1: 580-585. PMID 27623055 DOI: 10.1021/acsinfecdis.5b00025  0.48
2015 Maksymiuk C, Ioerger T, Balakrishnan A, Bryk R, Rhee K, Sacchettini J, Nathan C. Comparison of transposon and deletion mutants in Mycobacterium tuberculosis: The case of rv1248c, encoding 2-hydroxy-3-oxoadipate synthase. Tuberculosis (Edinburgh, Scotland). 95: 689-94. PMID 26547230 DOI: 10.1016/j.tube.2015.08.009  1
2015 Nathan C. IMMUNOLOGY. From transient infection to chronic disease. Science (New York, N.Y.). 350: 161. PMID 26450196 DOI: 10.1126/science.aad4141  1
2015 Maksymiuk C, Balakrishnan A, Bryk R, Rhee KY, Nathan CF. E1 of α-ketoglutarate dehydrogenase defends Mycobacterium tuberculosis against glutamate anaplerosis and nitroxidative stress. Proceedings of the National Academy of Sciences of the United States of America. 112: E5834-43. PMID 26430237 DOI: 10.1073/pnas.1510932112  1
2015 Nathan C. Cooperative development of antimicrobials: looking back to look ahead. Nature Reviews. Microbiology. 13: 651-7. PMID 26373373 DOI: 10.1038/nrmicro3523  1
2015 Zhao N, Sun M, Burns-Huang K, Jiang X, Ling Y, Darby C, Ehrt S, Liu G, Nathan C. Identification of Rv3852 as an Agrimophol-Binding Protein in Mycobacterium tuberculosis. Plos One. 10: e0126211. PMID 25978362 DOI: 10.1371/journal.pone.0126211  1
2015 Gold B, Warrier T, Nathan C. A multi-stress model for high throughput screening against non-replicating Mycobacterium tuberculosis. Methods in Molecular Biology (Clifton, N.J.). 1285: 293-315. PMID 25779324 DOI: 10.1007/978-1-4939-2450-9_18  1
2015 Nathan C, Barry CE. TB drug development: immunology at the table. Immunological Reviews. 264: 308-18. PMID 25703568 DOI: 10.1111/imr.12275  1
2015 Nathan C. What can immunology contribute to the control of the world's leading cause of death from bacterial infection? Immunological Reviews. 264: 2-5. PMID 25703548 DOI: 10.1111/imr.12277  1
2015 Vaubourgeix J, Lin G, Dhar N, Chenouard N, Jiang X, Botella H, Lupoli T, Mariani O, Yang G, Ouerfelli O, Unser M, Schnappinger D, McKinney J, Nathan C. Stressed mycobacteria use the chaperone ClpB to sequester irreversibly oxidized proteins asymmetrically within and between cells. Cell Host & Microbe. 17: 178-90. PMID 25620549 DOI: 10.1016/j.chom.2014.12.008  1
2015 Zhao N, Darby CM, Small J, Bachovchin DA, Jiang X, Burns-Huang KE, Botella H, Ehrt S, Boger DL, Anderson ED, Cravatt BF, Speers AE, Fernandez-Vega V, Hodder PS, Eberhart C, ... ... Nathan CF, et al. Target-based screen against a periplasmic serine protease that regulates intrabacterial pH homeostasis in Mycobacterium tuberculosis. Acs Chemical Biology. 10: 364-71. PMID 25457457 DOI: 10.1021/cb500746z  1
2014 Nathan C, Cars O. Antibiotic resistance--problems, progress, and prospects. The New England Journal of Medicine. 371: 1761-3. PMID 25271470 DOI: 10.1056/NEJMp1408040  1
2014 Nandakumar M, Nathan C, Rhee KY. Isocitrate lyase mediates broad antibiotic tolerance in Mycobacterium tuberculosis. Nature Communications. 5: 4306. PMID 24978671 DOI: 10.1038/ncomms5306  1
2014 Fan H, Angelo NG, Warren JD, Nathan CF, Lin G. Oxathiazolones Selectively Inhibit the Human Immunoproteasome over the Constitutive Proteasome. Acs Medicinal Chemistry Letters. 5: 405-10. PMID 24900849 DOI: 10.1021/ml400531d  1
2014 Zheng P, Somersan-Karakaya S, Lu S, Roberts J, Pingle M, Warrier T, Little D, Guo X, Brickner SJ, Nathan CF, Gold B, Liu G. Synthetic calanolides with bactericidal activity against replicating and nonreplicating Mycobacterium tuberculosis. Journal of Medicinal Chemistry. 57: 3755-72. PMID 24694175 DOI: 10.1021/jm4019228  1
2014 Gong Y, Somersan Karakaya S, Guo X, Zheng P, Gold B, Ma Y, Little D, Roberts J, Warrier T, Jiang X, Pingle M, Nathan CF, Liu G. Benzimidazole-based compounds kill Mycobacterium tuberculosis. European Journal of Medicinal Chemistry. 75: 336-53. PMID 24556148 DOI: 10.1016/j.ejmech.2014.01.039  1
2014 Nathan C. Drug-resistant tuberculosis: a new shot on goal. Nature Medicine. 20: 121-3. PMID 24504402 DOI: 10.1038/nm.3470  1
2013 Bryk R, Arango N, Maksymiuk C, Balakrishnan A, Wu YT, Wong CH, Masquelin T, Hipskind P, Lima CD, Nathan C. Lipoamide channel-binding sulfonamides selectively inhibit mycobacterial lipoamide dehydrogenase. Biochemistry. 52: 9375-84. PMID 24251446 DOI: 10.1021/bi401077f  1
2013 Rath P, Huang C, Wang T, Wang T, Li H, Prados-Rosales R, Elemento O, Casadevall A, Nathan CF. Genetic regulation of vesiculogenesis and immunomodulation in Mycobacterium tuberculosis. Proceedings of the National Academy of Sciences of the United States of America. 110: E4790-7. PMID 24248369 DOI: 10.1073/pnas.1320118110  1
2013 Cunningham-Bussel A, Zhang T, Nathan CF. Nitrite produced by Mycobacterium tuberculosis in human macrophages in physiologic oxygen impacts bacterial ATP consumption and gene expression. Proceedings of the National Academy of Sciences of the United States of America. 110: E4256-65. PMID 24145454 DOI: 10.1073/pnas.1316894110  1
2013 Cunningham-Bussel A, Bange FC, Nathan CF. Nitrite impacts the survival of Mycobacterium tuberculosis in response to isoniazid and hydrogen peroxide. Microbiologyopen. 2: 901-11. PMID 24019302 DOI: 10.1002/mbo3.126  1
2013 Darby CM, Ingólfsson HI, Jiang X, Shen C, Sun M, Zhao N, Burns K, Liu G, Ehrt S, Warren JD, Andersen OS, Anderson OS, Brickner SJ, Nathan C. Whole cell screen for inhibitors of pH homeostasis in Mycobacterium tuberculosis. Plos One. 8: e68942. PMID 23935911 DOI: 10.1371/journal.pone.0068942  1
2013 Lin G, Chidawanyika T, Tsu C, Warrier T, Vaubourgeix J, Blackburn C, Gigstad K, Sintchak M, Dick L, Nathan C. N,C-capped dipeptides with selectivity for mycobacterial proteasome over human proteasomes: Role of S3 and S1 binding pockets Journal of the American Chemical Society. 135: 9968-9971. PMID 23782398 DOI: 10.1021/ja400021x  1
2013 Balakrishnan A, Jordan F, Nathan CF. Influence of allosteric regulators on individual steps in the reaction catalyzed by Mycobacterium tuberculosis 2-hydroxy-3-oxoadipate synthase. The Journal of Biological Chemistry. 288: 21688-702. PMID 23760263 DOI: 10.1074/jbc.M113.465419  1
2013 Hou YJ, Banerjee R, Thomas B, Nathan C, García-Sastre A, Ding A, Uccellini MB. SARM is required for neuronal injury and cytokine production in response to central nervous system viral infection. Journal of Immunology (Baltimore, Md. : 1950). 191: 875-83. PMID 23749635 DOI: 10.4049/jimmunol.1300374  1
2013 Nathan C, Cunningham-Bussel A. Beyond oxidative stress: an immunologist's guide to reactive oxygen species. Nature Reviews. Immunology. 13: 349-61. PMID 23618831 DOI: 10.1038/nri3423  1
2013 Shigyo K, Ocheretina O, Merveille YM, Johnson WD, Pape JW, Nathan CF, Fitzgerald DW. Efficacy of nitazoxanide against clinical isolates of Mycobacterium tuberculosis. Antimicrobial Agents and Chemotherapy. 57: 2834-7. PMID 23507275 DOI: 10.1128/AAC.02542-12  1
2012 Nathan C. Fresh approaches to anti-infective therapies. Science Translational Medicine. 4: 140sr2. PMID 22745440 DOI: 10.1126/scitranslmed.3003081  1
2012 Osterloh JM, Yang J, Rooney TM, Fox AN, Adalbert R, Powell EH, Sheehan AE, Avery MA, Hackett R, Logan MA, MacDonald JM, Ziegenfuss JS, Milde S, Hou YJ, Nathan C, et al. dSarm/Sarm1 is required for activation of an injury-induced axon death pathway. Science (New York, N.Y.). 337: 481-4. PMID 22678360 DOI: 10.1126/science.1223899  1
2012 Nathan C. Secretory products of macrophages: twenty-five years on. The Journal of Clinical Investigation. 122: 1189-90. PMID 22570864 DOI: 10.1172/JCI62930  1
2012 Wu K, Koo J, Jiang X, Chen R, Cohen SN, Nathan C. Improved control of tuberculosis and activation of macrophages in mice lacking protein kinase R. Plos One. 7: e30512. PMID 22359543 DOI: 10.1371/journal.pone.0030512  1
2011 de Carvalho LP, Darby CM, Rhee KY, Nathan C. Nitazoxanide Disrupts Membrane Potential and Intrabacterial pH Homeostasis of Mycobacterium tuberculosis. Acs Medicinal Chemistry Letters. 2: 849-854. PMID 22096616 DOI: 10.1021/ml200157f  1
2011 Nathan C. Is iNOS beginning to smoke? Cell. 147: 257-8. PMID 22000003 DOI: 10.1016/j.cell.2011.09.031  1
2011 Vogt G, Nathan C. In vitro differentiation of human macrophages with enhanced antimycobacterial activity. The Journal of Clinical Investigation. 121: 3889-901. PMID 21911939 DOI: 10.1172/JCI57235  1
2011 Darby CM, Venugopal A, Ehrt S, Nathan CF. Mycobacterium tuberculosis gene Rv2136c is dispensable for acid resistance and virulence in mice. Tuberculosis (Edinburgh, Scotland). 91: 343-7. PMID 21778115 DOI: 10.1016/j.tube.2011.06.007  1
2011 Bryk R, Wu K, Raimundo BC, Boardman PE, Chao P, Conn GL, Anderson E, Cole JL, Duffy NP, Nathan C, Griffin JH. Identification of new inhibitors of protein kinase R guided by statistical modeling. Bioorganic & Medicinal Chemistry Letters. 21: 4108-14. PMID 21632247 DOI: 10.1016/j.bmcl.2011.04.149  1
2011 Nathan C. Making space for anti-infective drug discovery. Cell Host & Microbe. 9: 343-8. PMID 21575903 DOI: 10.1016/j.chom.2011.04.013  1
2011 Rhee KY, de Carvalho LP, Bryk R, Ehrt S, Marrero J, Park SW, Schnappinger D, Venugopal A, Nathan C. Central carbon metabolism in Mycobacterium tuberculosis: an unexpected frontier. Trends in Microbiology. 19: 307-14. PMID 21561773 DOI: 10.1016/j.tim.2011.03.008  1
2011 Venugopal A, Bryk R, Shi S, Rhee K, Rath P, Schnappinger D, Ehrt S, Nathan C. Virulence of Mycobacterium tuberculosis depends on lipoamide dehydrogenase, a member of three multienzyme complexes. Cell Host & Microbe. 9: 21-31. PMID 21238944 DOI: 10.1016/j.chom.2010.12.004  1
2011 Mazloum N, Stegman MA, Croteau DL, Van Houten B, Kwon NS, Ling Y, Dickinson C, Venugopal A, Towheed MA, Nathan C. Identification of a chemical that inhibits the mycobacterial UvrABC complex in nucleotide excision repair. Biochemistry. 50: 1329-35. PMID 21235228 DOI: 10.1021/bi101674c  1
2010 Beaulieu AM, Rath P, Imhof M, Siddall ME, Roberts J, Schnappinger D, Nathan CF. Genome-wide screen for Mycobacterium tuberculosis genes that regulate host immunity. Plos One. 5: e15120. PMID 21170273 DOI: 10.1371/journal.pone.0015120  1
2010 de Carvalho LP, Fischer SM, Marrero J, Nathan C, Ehrt S, Rhee KY. Metabolomics of Mycobacterium tuberculosis reveals compartmentalized co-catabolism of carbon substrates. Chemistry & Biology. 17: 1122-31. PMID 21035735 DOI: 10.1016/j.chembiol.2010.08.009  1
2010 Zhao H, de Carvalho LP, Nathan C, Ouerfelli O. A protecting group-free synthesis of deazathiamine: a step toward inhibitor design. Bioorganic & Medicinal Chemistry Letters. 20: 6472-4. PMID 20943392 DOI: 10.1016/j.bmcl.2010.09.053  0.32
2010 Seimon TA, Kim MJ, Blumenthal A, Koo J, Ehrt S, Wainwright H, Bekker LG, Kaplan G, Nathan C, Tabas I, Russell DG. Induction of ER stress in macrophages of tuberculosis granulomas. Plos One. 5: e12772. PMID 20856677 DOI: 10.1371/journal.pone.0012772  1
2010 Yin F, Dumont M, Banerjee R, Ma Y, Li H, Lin MT, Beal MF, Nathan C, Thomas B, Ding A. Behavioral deficits and progressive neuropathology in progranulin-deficient mice: a mouse model of frontotemporal dementia. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. 24: 4639-47. PMID 20667979 DOI: 10.1096/fj.10-161471  1
2010 Lin G, Li D, Chidawanyika T, Nathan C, Li H. Fellutamide B is a potent inhibitor of the Mycobacterium tuberculosis proteasome. Archives of Biochemistry and Biophysics. 501: 214-20. PMID 20558127 DOI: 10.1016/j.abb.2010.06.009  0.6
2010 Darby CM, Nathan CF. Killing of non-replicating Mycobacterium tuberculosis by 8-hydroxyquinoline. The Journal of Antimicrobial Chemotherapy. 65: 1424-7. PMID 20435781 DOI: 10.1093/jac/dkq145  1
2010 de Carvalho LP, Zhao H, Dickinson CE, Arango NM, Lima CD, Fischer SM, Ouerfelli O, Nathan C, Rhee KY. Activity-based metabolomic profiling of enzymatic function: identification of Rv1248c as a mycobacterial 2-hydroxy-3-oxoadipate synthase. Chemistry & Biology. 17: 323-32. PMID 20416504 DOI: 10.1016/j.chembiol.2010.03.009  1
2010 Nathan C, Ding A. SnapShot: Reactive Oxygen Intermediates (ROI). Cell. 140: 951-951.e2. PMID 20303882 DOI: 10.1016/j.cell.2010.03.008  1
2010 Nathan C, Ding A. Nonresolving inflammation. Cell. 140: 871-82. PMID 20303877 DOI: 10.1016/j.cell.2010.02.029  1
2010 Bryk R, Arango N, Venugopal A, Warren JD, Park YH, Patel MS, Lima CD, Nathan C. Triazaspirodimethoxybenzoyls as selective inhibitors of mycobacterial lipoamide dehydrogenase . Biochemistry. 49: 1616-27. PMID 20078138 DOI: 10.1021/bi9016186  1
2010 Yin F, Banerjee R, Thomas B, Zhou P, Qian L, Jia T, Ma X, Ma Y, Iadecola C, Beal MF, Nathan C, Ding A. Exaggerated inflammation, impaired host defense, and neuropathology in progranulin-deficient mice. The Journal of Experimental Medicine. 207: 117-28. PMID 20026663 DOI: 10.1084/jem.20091568  1
2010 Dumont M, Wille E, Calingasan NY, Nathan C, Flint Beal M, Lin MT. N-iminoethyl-L-lysine improves memory and reduces amyloid pathology in a transgenic mouse model of amyloid deposition. Neurochemistry International. 56: 345-51. PMID 19914323 DOI: 10.1016/j.neuint.2009.11.006  1
2009 Wang T, Li H, Lin G, Tang C, Li D, Nathan C, Darwin KH, Li H. Structural insights on the Mycobacterium tuberculosis proteasomal ATPase Mpa. Structure (London, England : 1993). 17: 1377-85. PMID 19836337 DOI: 10.1016/j.str.2009.08.010  0.6
2009 Lin G, Li D, de Carvalho LP, Deng H, Tao H, Vogt G, Wu K, Schneider J, Chidawanyika T, Warren JD, Li H, Nathan C. Inhibitors selective for mycobacterial versus human proteasomes. Nature. 461: 621-6. PMID 19759536 DOI: 10.1038/nature08357  1
2009 de Carvalho LP, Lin G, Jiang X, Nathan C. Nitazoxanide kills replicating and nonreplicating Mycobacterium tuberculosis and evades resistance. Journal of Medicinal Chemistry. 52: 5789-92. PMID 19736929 DOI: 10.1021/jm9010719  0.6
2009 Vandal OH, Nathan CF, Ehrt S. Acid resistance in Mycobacterium tuberculosis. Journal of Bacteriology. 191: 4714-21. PMID 19465648 DOI: 10.1128/JB.00305-09  1
2009 Nathan C. Taming tuberculosis: a challenge for science and society. Cell Host & Microbe. 5: 220-4. PMID 19286131 DOI: 10.1016/j.chom.2009.02.004  1
2009 Lee WL, Gold B, Darby C, Brot N, Jiang X, de Carvalho LP, Wellner D, St John G, Jacobs WR, Nathan C. Mycobacterium tuberculosis expresses methionine sulphoxide reductases A and B that protect from killing by nitrite and hypochlorite. Molecular Microbiology. 71: 583-93. PMID 19040639 DOI: 10.1111/j.1365-2958.2008.06548.x  1
2009 Vandal OH, Roberts JA, Odaira T, Schnappinger D, Nathan CF, Ehrt S. Acid-susceptible mutants of Mycobacterium tuberculosis share hypersusceptibility to cell wall and oxidative stress and to the host environment. Journal of Bacteriology. 191: 625-31. PMID 19011036 DOI: 10.1128/JB.00932-08  1
2008 Nathan C. Microbiology. An antibiotic mimics immunity. Science (New York, N.Y.). 322: 1337-8. PMID 19039126 DOI: 10.1126/science.1167452  1
2008 Lin G, Tsu C, Dick L, Zhou XK, Nathan C. Distinct specificities of Mycobacterium tuberculosis and mammalian proteasomes for N-acetyl tripeptide substrates. The Journal of Biological Chemistry. 283: 34423-31. PMID 18829465 DOI: 10.1074/jbc.M805324200  1
2008 Nathan C, Gold B, Lin G, Stegman M, de Carvalho LP, Vandal O, Venugopal A, Bryk R. A philosophy of anti-infectives as a guide in the search for new drugs for tuberculosis. Tuberculosis (Edinburgh, Scotland). 88: S25-33. PMID 18762150 DOI: 10.1016/S1472-9792(08)70034-9  0.64
2008 Gold B, Deng H, Bryk R, Vargas D, Eliezer D, Roberts J, Jiang X, Nathan C. Identification of a copper-binding metallothionein in pathogenic mycobacteria. Nature Chemical Biology. 4: 609-16. PMID 18724363 DOI: 10.1038/nchembio.109  0.64
2008 Vandal OH, Pierini LM, Schnappinger D, Nathan CF, Ehrt S. A membrane protein preserves intrabacterial pH in intraphagosomal Mycobacterium tuberculosis. Nature Medicine. 14: 849-54. PMID 18641659 DOI: 10.1038/nm.1795  1
2008 Nathan C. Metchnikoff's Legacy in 2008. Nature Immunology. 9: 695-8. PMID 18563074 DOI: 10.1038/ni0708-695  1
2008 Nathan C. Epidemic inflammation: pondering obesity. Molecular Medicine (Cambridge, Mass.). 14: 485-92. PMID 18431463 DOI: 10.2119/2008-00038.Nathan  1
2008 Bryk R, Gold B, Venugopal A, Singh J, Samy R, Pupek K, Cao H, Popescu C, Gurney M, Hotha S, Cherian J, Rhee K, Ly L, Converse PJ, Ehrt S, ... ... Nathan C, et al. Selective killing of nonreplicating mycobacteria. Cell Host & Microbe. 3: 137-45. PMID 18329613 DOI: 10.1016/j.chom.2008.02.003  1
2007 Bass AR, Schneider R, Sanders A, Flieder D, Nathan CF, Erkan D. Pulmonary nodules in an infliximab-treated rheumatoid arthritis patient: a clinical pathology conference held by the Division of Rheumatology at Hospital for Special Surgery. Hss Journal : the Musculoskeletal Journal of Hospital For Special Surgery. 3: 119-25. PMID 18751782 DOI: 10.1007/s11420-006-9032-1  1
2007 Casenghi M, Cole ST, Nathan CF. New approaches to filling the gap in tuberculosis drug discovery. Plos Medicine. 4: e293. PMID 17988169 DOI: 10.1371/journal.pmed.0040293  1
2007 Kim Y, Zhou P, Qian L, Chuang JZ, Lee J, Li C, Iadecola C, Nathan C, Ding A. MyD88-5 links mitochondria, microtubules, and JNK3 in neurons and regulates neuronal survival. The Journal of Experimental Medicine. 204: 2063-74. PMID 17724133 DOI: 10.1084/jem.20070868  1
2007 Nathan C. Aligning pharmaceutical innovation with medical need. Nature Medicine. 13: 304-8. PMID 17342145 DOI: 10.1038/nm0307-304  1
2007 Fang FC, Nathan CF. Man is not a mouse: reply. Journal of Leukocyte Biology. 81: 580. PMID 17332374 DOI: 10.1189/jlb.1206715  1
2006 Nathan C. Role of iNOS in human host defense. Science (New York, N.Y.). 312: 1874-5; author reply. PMID 16809512 DOI: 10.1126/science.312.5782.1874b  1
2006 Nathan C. Neutrophils and immunity: challenges and opportunities. Nature Reviews. Immunology. 6: 173-82. PMID 16498448 DOI: 10.1038/nri1785  1
2006 Vandal OH, Gelb MH, Ehrt S, Nathan CF. Cytosolic phospholipase A2 enzymes are not required by mouse bone marrow-derived macrophages for the control of Mycobacterium tuberculosis in vitro. Infection and Immunity. 74: 1751-6. PMID 16495548 DOI: 10.1128/IAI.74.3.1751-1756.2006  1
2006 Hu G, Lin G, Wang M, Dick L, Xu RM, Nathan C, Li H. Structure of the Mycobacterium tuberculosis proteasome and mechanism of inhibition by a peptidyl boronate. Molecular Microbiology. 59: 1417-28. PMID 16468986 DOI: 10.1111/j.1365-2958.2005.05036.x  0.6
2006 Lin G, Hu G, Tsu C, Kunes YZ, Li H, Dick L, Parsons T, Li P, Chen Z, Zwickl P, Weich N, Nathan C. Mycobacterium tuberculosis prcBA genes encode a gated proteasome with broad oligopeptide specificity. Molecular Microbiology. 59: 1405-16. PMID 16468985 DOI: 10.1111/j.1365-2958.2005.05035.x  1
2006 Han H, Roberts J, Lou O, Muller WA, Nathan N, Nathan C. Chemical inhibitors of TNF signal transduction in human neutrophils point to distinct steps in cell activation. Journal of Leukocyte Biology. 79: 147-54. PMID 16275893 DOI: 10.1189/jlb.0605308  0.48
2005 Nathan C, Calingasan N, Nezezon J, Ding A, Lucia MS, La Perle K, Fuortes M, Lin M, Ehrt S, Kwon NS, Chen J, Vodovotz Y, Kipiani K, Beal MF. Protection from Alzheimer's-like disease in the mouse by genetic ablation of inducible nitric oxide synthase. The Journal of Experimental Medicine. 202: 1163-9. PMID 16260491 DOI: 10.1084/jem.20051529  1
2005 Nathan C, Goldberg FM. Outlook: the profit problem in antibiotic R&D. Nature Reviews. Drug Discovery. 4: 887-91. PMID 16247440 DOI: 10.1038/nrd1878  1
2005 Smith I, Nathan C, Peavy HH. Progress and new directions in genetics of tuberculosis: an NHLBI working group report. American Journal of Respiratory and Critical Care Medicine. 172: 1491-6. PMID 16192449 DOI: 10.1164/rccm.200506-997WS  1
2005 Rajashankar KR, Bryk R, Kniewel R, Buglino JA, Nathan CF, Lima CD. Crystal structure and functional analysis of lipoamide dehydrogenase from Mycobacterium tuberculosis. The Journal of Biological Chemistry. 280: 33977-83. PMID 16093239 DOI: 10.1074/jbc.M507466200  1
2005 Tian J, Bryk R, Shi S, Erdjument-Bromage H, Tempst P, Nathan C. Mycobacterium tuberculosis appears to lack alpha-ketoglutarate dehydrogenase and encodes pyruvate dehydrogenase in widely separated genes. Molecular Microbiology. 57: 859-68. PMID 16045627 DOI: 10.1111/j.1365-2958.2005.04741.x  0.64
2005 Han H, Stessin A, Roberts J, Hess K, Gautam N, Kamenetsky M, Lou O, Hyde E, Nathan N, Muller WA, Buck J, Levin LR, Nathan C. Calcium-sensing soluble adenylyl cyclase mediates TNF signal transduction in human neutrophils. The Journal of Experimental Medicine. 202: 353-61. PMID 16043520 DOI: 10.1084/jem.20050778  1
2005 Darwin KH, Nathan CF. Role for nucleotide excision repair in virulence of Mycobacterium tuberculosis. Infection and Immunity. 73: 4581-7. PMID 16040969 DOI: 10.1128/IAI.73.8.4581-4587.2005  1
2005 Tian J, Bryk R, Itoh M, Suematsu M, Nathan C. Variant tricarboxylic acid cycle in Mycobacterium tuberculosis: identification of alpha-ketoglutarate decarboxylase. Proceedings of the National Academy of Sciences of the United States of America. 102: 10670-5. PMID 16027371 DOI: 10.1073/pnas.0501605102  0.64
2005 Kaufmann SH, Cole ST, Mizrahi V, Rubin E, Nathan C. Mycobacterium tuberculosis and the host response. The Journal of Experimental Medicine. 201: 1693-7. PMID 15939785 DOI: 10.1084/jem.20050842  1
2005 Hisert KB, MacCoss M, Shiloh MU, Darwin KH, Singh S, Jones RA, Ehrt S, Zhang Z, Gaffney BL, Gandotra S, Holden DW, Murray D, Nathan C. A glutamate-alanine-leucine (EAL) domain protein of Salmonella controls bacterial survival in mice, antioxidant defence and killing of macrophages: role of cyclic diGMP. Molecular Microbiology. 56: 1234-45. PMID 15882417 DOI: 10.1111/j.1365-2958.2005.04632.x  1
2005 Darwin KH, Lin G, Chen Z, Li H, Nathan CF. Characterization of a Mycobacterium tuberculosis proteasomal ATPase homologue. Molecular Microbiology. 55: 561-71. PMID 15659170 DOI: 10.1111/j.1365-2958.2004.04403.x  1
2005 Rhee KY, Erdjument-Bromage H, Tempst P, Nathan CF. S-nitroso proteome of Mycobacterium tuberculosis: Enzymes of intermediary metabolism and antioxidant defense. Proceedings of the National Academy of Sciences of the United States of America. 102: 467-72. PMID 15626759 DOI: 10.1073/pnas.0406133102  1
2004 Nathan C. The moving frontier in nitric oxide-dependent signaling. Science's Stke : Signal Transduction Knowledge Environment. 2004: pe52. PMID 15523044 DOI: 10.1126/stke.2572004pe52  1
2004 Nathan C. Antibiotics at the crossroads. Nature. 431: 899-902. PMID 15496893 DOI: 10.1038/431899a  1
2004 Hisert KB, Kirksey MA, Gomez JE, Sousa AO, Cox JS, Jacobs WR, Nathan CF, McKinney JD. Identification of Mycobacterium tuberculosis counterimmune (cim) mutants in immunodeficient mice by differential screening. Infection and Immunity. 72: 5315-21. PMID 15322028 DOI: 10.1128/IAI.72.9.5315-5321.2004  1
2003 Darwin KH, Ehrt S, Gutierrez-Ramos JC, Weich N, Nathan CF. The proteasome of Mycobacterium tuberculosis is required for resistance to nitric oxide. Science (New York, N.Y.). 302: 1963-6. PMID 14671303 DOI: 10.1126/science.1091176  1
2003 Shi S, Nathan C, Schnappinger D, Drenkow J, Fuortes M, Block E, Ding A, Gingeras TR, Schoolnik G, Akira S, Takeda K, Ehrt S. MyD88 primes macrophages for full-scale activation by interferon-gamma yet mediates few responses to Mycobacterium tuberculosis. The Journal of Experimental Medicine. 198: 987-97. PMID 14517275 DOI: 10.1084/jem.20030603  1
2003 Schnappinger D, Ehrt S, Voskuil MI, Liu Y, Mangan JA, Monahan IM, Dolganov G, Efron B, Butcher PD, Nathan C, Schoolnik GK. Transcriptional Adaptation of Mycobacterium tuberculosis within Macrophages: Insights into the Phagosomal Environment. The Journal of Experimental Medicine. 198: 693-704. PMID 12953091 DOI: 10.1084/jem.20030846  1
2003 Nathan C. Immunology: Oxygen and the inflammatory cell. Nature. 422: 675-6. PMID 12700748 DOI: 10.1038/422675a  1
2003 Nathan C. Specificity of a third kind: reactive oxygen and nitrogen intermediates in cell signaling. The Journal of Clinical Investigation. 111: 769-78. PMID 12639979 DOI: 10.1172/JCI18174  1
2003 Han H, Fuortes M, Nathan C. Critical role of the carboxyl terminus of proline-rich tyrosine kinase (Pyk2) in the activation of human neutrophils by tumor necrosis factor: separation of signals for the respiratory burst and degranulation. The Journal of Experimental Medicine. 197: 63-75. PMID 12515814 DOI: 10.1084/jem.20021638  1
2002 Zhu J, Nathan C, Jin W, Sim D, Ashcroft GS, Wahl SM, Lacomis L, Erdjument-Bromage H, Tempst P, Wright CD, Ding A. Conversion of proepithelin to epithelins: roles of SLPI and elastase in host defense and wound repair. Cell. 111: 867-78. PMID 12526812  0.44
2002 Nathan C. Points of control in inflammation. Nature. 420: 846-52. PMID 12490957 DOI: 10.1038/nature01320  1
2002 Nathan C. Immunology. Catalytic antibody bridges innate and adaptive immunity. Science (New York, N.Y.). 298: 2143-4. PMID 12481124 DOI: 10.1126/science.1080005  1
2002 Nathan C. Inducible nitric oxide synthase in the tuberculous human lung. American Journal of Respiratory and Critical Care Medicine. 166: 130-1. PMID 12119220 DOI: 10.1164/rccm.2205016  1
2002 Shen C, Nathan C. Nonredundant antioxidant defense by multiple two-cysteine peroxiredoxins in human prostate cancer cells. Molecular Medicine (Cambridge, Mass.). 8: 95-102. PMID 12080185  1
2002 Weissbach H, Etienne F, Hoshi T, Heinemann SH, Lowther WT, Matthews B, St John G, Nathan C, Brot N. Peptide methionine sulfoxide reductase: structure, mechanism of action, and biological function. Archives of Biochemistry and Biophysics. 397: 172-8. PMID 11795868 DOI: 10.1006/abbi.2001.2664  1
2001 Ehrt S, Schnappinger D, Bekiranov S, Drenkow J, Shi S, Gingeras TR, Gaasterland T, Schoolnik G, Nathan C. Reprogramming of the macrophage transcriptome in response to interferon-gamma and Mycobacterium tuberculosis: signaling roles of nitric oxide synthase-2 and phagocyte oxidase. The Journal of Experimental Medicine. 194: 1123-40. PMID 11602641 DOI: 10.1084/jem.194.8.1123  1
2001 St. John G, Brot N, Ruan J, Erdjument-Bromage H, Tempst P, Weissbach H, Nathan C. Peptide methionine sulfoxide reductase from Escherichia coli and Mycobacterium tuberculosis protects bacteria against oxidative damage from reactive nitrogen intermediates Proceedings of the National Academy of Sciences of the United States of America. 98: 9901-9906. PMID 11481433 DOI: 10.1073/pnas.161295398  1
2001 Nathan C, Ding A. TREM-1: A new regulator of innate immunity in sepsis syndrome Nature Medicine. 7: 530-532. PMID 11329047 DOI: 10.1038/87846  1
2001 Nathan C, Muller WA. Putting the brakes on innate immunity: A regulatory role for CD200? Nature Immunology. 2: 17-19. PMID 11135572 DOI: 10.1038/83124  1
2000 Bryk R, Griffin P, Nathan C. Peroxynitrite reductase activity of bacterial peroxiredoxins Nature. 407: 211-215. PMID 11001062 DOI: 10.1038/35025109  1
2000 Nathan C, Shiloh MU. Reactive oxygen and nitrogen intermediates in the relationship between mammalian hosts and microbial pathogens. Proceedings of the National Academy of Sciences of the United States of America. 97: 8841-8. PMID 10922044 DOI: 10.1073/pnas.97.16.8841  1
2000 Grobmyer SR, Barie PS, Nathan CF, Fuortes M, Lin E, Lowry SF, Wright CD, Weyant MJ, Hydo L, Reeves F, Shiloh MU, Ding A. Secretory leukocyte protease inhibitor, an inhibitor of neutrophil activation, is elevated in serum in human sepsis and experimental endotoxemia. Critical Care Medicine. 28: 1276-82. PMID 10834665  1
2000 Shiloh MU, Nathan CF. Reactive nitrogen intermediates and the pathogenesis of Salmonella and mycobacteria. Current Opinion in Microbiology. 3: 35-42. PMID 10679417 DOI: 10.1016/S1369-5274(99)00048-X  1
1999 Zhu J, Nathan C, Ding A. Suppression of macrophage responses to bacterial lipopolysaccharide by a non-secretory form of secretory leukocyte protease inhibitor Biochimica Et Biophysica Acta - Molecular Cell Research. 1451: 219-223. PMID 10556576 DOI: 10.1016/S0167-4889(99)00111-1  1
1999 Fuortes M, Melchior M, Han H, Lyon GJ, Nathan C. Role of the tyrosine kinase pyk2 in the integrin-dependent activation of human neutrophils by TNF. The Journal of Clinical Investigation. 104: 327-35. PMID 10430614 DOI: 10.1172/JCI6018  1
1999 Ruan J, St John G, Ehrt S, Riley L, Nathan C. noxR3, a novel gene from Mycobacterium tuberculosis, protects Salmonella typhimurium from nitrosative and oxidative stress. Infection and Immunity. 67: 3276-83. PMID 10377101  1
1999 Nicholson SC, Grobmyer SR, Shiloh MU, Brause JE, Potter S, MacMicking JD, Dinauer MC, Nathan CF. Lethality of endotoxin in mice genetically deficient in the respiratory burst oxidase, inducible nitric oxide synthase, or both. Shock (Augusta, Ga.). 11: 253-8. PMID 10220301  1
1999 Shiloh MU, MacMicking JD, Nicholson S, Brause JE, Potter S, Marino M, Fang F, Dinauer M, Nathan C. Phenotype of mice and macrophages deficient in both phagocyte oxidase and inducible nitric oxide synthase. Immunity. 10: 29-38. PMID 10023768 DOI: 10.1016/S1074-7613(00)80004-7  1
1999 Shiloh MU, Nathan CF. Antimicrobial mechanisms of macrophages Advances in Cellular and Molecular Biology of Membranes and Organelles. 5: 407-439. DOI: 10.1016/S1874-5172(99)80042-X  1
1998 Jin F, Nathan C, Ding A. Identification of genes involved in innate responsiveness to bacterial products by differential display Methods: a Companion to Methods in Enzymology. 16: 396-406. PMID 10049647 DOI: 10.1006/meth.1998.0694  1
1998 Chen L, Xie QW, Nathan C. Alkyl hydroperoxide reductase subunit C (AhpC) protects bacterial and human cells against reactive nitrogen intermediates Molecular Cell. 1: 795-805. PMID 9660963  1
1997 De Groote MA, Ochsner UA, Shiloh MU, Nathan C, McCord JM, Dinauer MC, Libby SJ, Vazquez-Torres A, Xu Y, Fang FC. Periplasmic superoxide dismutase protects Salmonella from products of phagocyte NADPH-oxidase and nitric oxide synthase. Proceedings of the National Academy of Sciences of the United States of America. 94: 13997-4001. PMID 9391141 DOI: 10.1073/pnas.94.25.13997  1
1997 Ehrt S, Shiloh MU, Ruan J, Choi M, Gunzburg S, Nathan C, Xie Q, Riley LW. A novel antioxidant gene from Mycobacterium tuberculosis. The Journal of Experimental Medicine. 186: 1885-96. PMID 9382887 DOI: 10.1084/jem.186.11.1885  1
1997 Nathan C. Inducible nitric oxide synthase: What difference does it make? Journal of Clinical Investigation. 100: 2417-2423. PMID 9366554  1
1997 Shiloh MU, Ruan J, Nathan C. Evaluation of bacterial survival and phagocyte function with a fluorescence-based microplate assay. Infection and Immunity. 65: 3193-8. PMID 9234774  1
1997 MacMicking J, Xie QW, Nathan C. Nitric oxide and macrophage function Annual Review of Immunology. 15: 323-350. PMID 9143691 DOI: 10.1146/annurev.immunol.15.1.323  1
1997 Jin FY, Nathan C, Radzioch D, Ding A. Secretory leukocyte protease inhibitor: A macrophage product induced by and antagonistic to bacterial lipopolysaccharide Cell. 88: 417-426. PMID 9039268 DOI: 10.1016/S0092-8674(00)81880-2  1
1996 Fuortes M, Jin WW, Nathan C. Ceramide selectively inhibits early events in the response of human neutrophils to tumor necrosis factor Journal of Leukocyte Biology. 59: 451-460. PMID 8604026  1
1995 Nathan C. Natural resistance and nitric oxide Cell. 82: 873-876. PMID 7553846 DOI: 10.1016/0092-8674(95)90019-5  1
1995 Nathan C. Inducible nitric oxide synthase: Regulation subserves function Current Topics in Microbiology and Immunology. 196: 1-4. PMID 7543397  1
1994 Celada A, Nathan C. Macrophage activation revisited Immunology Today. 15: 100-102. PMID 7909663 DOI: 10.1016/0167-5699(94)90150-3  1
1994 Sparrow JR, Nathan C, Vodovotz Y. Cytokine regulation of nitric oxide synthase in mouse retinal pigment epithelial cells in culture Experimental Eye Research. 59: 129-139. PMID 7530664 DOI: 10.1006/exer.1994.1091  1
1994 Xie QW, Nathan C. The high-output nitric oxide pathway: Role and regulation Journal of Leukocyte Biology. 56: 576-582. PMID 7525816  1
1994 Fuortes M, Jin WW, Nathan C. β2 Integrin-dependent tyrosine phosphorylation of paxillin in human neutrophils treated with tumor necrosis factor Journal of Cell Biology. 127: 1477-1483. PMID 7525608 DOI: 10.1083/jcb.127.5.1477  1
1994 Nathan C, Xie Qw. Nitric oxide synthases: Roles, tolls, and controls Cell. 78: 915-918. PMID 7522969 DOI: 10.1016/0092-8674(94)90266-6  1
1994 Martin E, Nathan C, Xie QW. Role of interferon regulatory factor 1 in induction of nitric oxide synthase Journal of Experimental Medicine. 180: 977-984. PMID 7520478 DOI: 10.1084/jem.180.3.977  1
1994 Nathan C, Xie QW. Regulation of biosynthesis of nitric oxide Journal of Biological Chemistry. 269: 13725-13728. PMID 7514592  1
1994 Nathan C. Nitric oxide and biopterin: A study in chiaroscuro Journal of Clinical Investigation. 93: 1875-1876. PMID 7514187  1
1994 Xie QW, Kashiwabara Y, Nathan C. Role of transcription factor NF-κB/Rel in induction of nitric oxide synthase Journal of Biological Chemistry. 269: 4705-4708. PMID 7508926  1
1993 Fuortes M, Jin WW, Nathan C. Adhesion-dependent protein tyrosine phosphorylation in neutrophils treated with tumor necrosis factor Journal of Cell Biology. 120: 777-784. PMID 8425901 DOI: 10.1083/jcb.120.3.777  1
1993 Bogdan C, Nathan C. Modulation of macrophage function by transforming growth factor β, interleukin-4, and interleukin-10 Annals of the New York Academy of Sciences. 685: 713-739. PMID 8363277  1
1993 Klebanoff SJ, Nathan CF. Nitrite production by stimulated human polymorphonuclear leukocytes supplemented with azide and catalase Biochemical and Biophysical Research Communications. 197: 192-196. PMID 8250925 DOI: 10.1006/bbrc.1993.2459  1
1993 Xie QW, Whisnant R, Nathan C. Promoter of the mouse gene encoding calcium-independent nitric oxide synthase confers inducibility by interferon γ and bacterial lipopolysaccharide Journal of Experimental Medicine. 177: 1779-1784. PMID 7684434  1
1993 Xie QW, Nathan C. Promoter of the mouse gene encoding calcium-independent nitric oxide synthase confers inducibility by interferon-gamma and bacterial lipopolysaccharide Transactions of the Association of American Physicians. 106: 1-12. PMID 7518621  1
1992 Ding A, Sanchez E, Tancinco M, Nathan C. Interactions of bacterial lipopolysaccharide with microtubule proteins Journal of Immunology. 148: 2853-2858. PMID 1573273  1
1992 Bogdan C, Paik J, Vodovotz Y, Nathan C. Contrasting mechanisms for suppression of macrophage cytokine release by transforming growth factor-β and interleukin-10 Journal of Biological Chemistry. 267: 23301-23308. PMID 1429677  1
1992 Nathan C. Nitric oxide as a secretory product of mammalian cells Faseb Journal. 6: 3051-3064. PMID 1381691  1
1992 Porteu F, Nathan CF. Mobilizable intracellular pool of p55 (type I) tumor necrosis factor receptors in human neutrophils Journal of Leukocyte Biology. 52: 122-124. PMID 1322441  1
1991 Nathan C. Workshop summary: Negative regulation of macrophage effector function Annals of the New York Academy of Sciences. 628: 410. PMID 2069317  1
1991 Nathan C. Mechanisms and modulation of macrophage activation Behring Institut Mitteilungen. 200-207. PMID 2049039  1
1991 Nathan C, Sporn M. Cytokines in context Journal of Cell Biology. 113: 981-986. PMID 2040651  1
1991 Szatrowski TP, Nathan CF. Production of Large Amounts of Hydrogen Peroxide by Human Tumor Cells Cancer Research. 51: 794-798. PMID 1846317  1
1991 Bogdan C, Vodovotz Y, Nathan C. Macrophage deactivation by interleukin 10. The Journal of Experimental Medicine. 174: 1549-55. PMID 1744584  1
1991 Nathan C. A commentary: inducible nitric oxide synthase Research in Immunology. 142: 600-602. PMID 1725935 DOI: 10.1016/0923-2494(91)90117-2  1
1990 Porteu F, Nathan C. Shedding of tumor necrosis factor receptors by activated human neutrophils Journal of Experimental Medicine. 172: 599-607. PMID 2165128 DOI: 10.1084/jem.172.2.599  1
1990 Srimal S, Nathan C. Purification of macrophage deactivating factor Journal of Experimental Medicine. 171: 1347-1361. PMID 2109038  1
1990 Nathan C, Sanchez E. Tumor necrosis factor and CD11/CD18 (β2) integrins act synergistically to lower cAMP in human neutrophils Journal of Cell Biology. 111: 2171-2181. PMID 1699953  1
1990 Nathan CF, Stuehr DJ. Does endothelium-derived nitric oxide have a rolein cytokine-induced hypotension? Journal of the National Cancer Institute. 82: 726-728. PMID 1691302 DOI: 10.1093/jnci/82.9.726  1
1989 Tsunawaki S, Sporn M, Nathan C. Comparison of transforming growth factor-β and a macrophage-deactivating polypeptide from tumor cells. Differences in antigenicity and mechanism of action Journal of Immunology. 142: 3462-3468. PMID 2715632  1
1989 Stuehr DJ, Nathan CF. Nitric oxide: A macrophage product responsible for cytostasis and respiratory inhibition in tumor target cells Journal of Experimental Medicine. 169: 1543-1555. PMID 2497225  1
1989 Nathan CF. Respiratory burst in adherent human neutrophils: Triggering by colony-stimulating factors CSF-GM and CSF-G Blood. 73: 301-306. PMID 2462939  1
1988 Ding AH, Nathan CF. The measurement of cytochrome b559 in polymorphonuclear leukocytes and macrophages in the presence of hemoglobin or mitochondrial cytochromes Analytical Biochemistry. 175: 22-29. PMID 3245568 DOI: 10.1016/0003-2697(88)90355-7  1
1988 Murray HW, Nathan CF. In vivo killing of intracellular visceral leishmania donovani by a macrophage-targeted hydrogen peroxide-generating system Journal of Infectious Diseases. 158: 1372-1375. PMID 3198943 DOI: 10.1093/infdis/158.6.1372  1
1988 Ding A, Nathan C. Analysis of the nonfunctional respiratory burst in murine Kupffer cells Journal of Experimental Medicine. 167: 1154-1170. PMID 3127523  1
1988 Tsunawaki S, Sporn M, Ding A, Nathan C. Deactivation of macrophages by transforming growth factor-β Nature. 334: 260-262. PMID 3041283  1
1987 Ding A, Wright SD, Nathan C. Activation of mouse peritoneal macrophages by monoclonal antibodies to Mac-1 (complement receptor type 3) Journal of Experimental Medicine. 165: 733-749. PMID 3102677  1
1987 Ding AH, Nathan CF. Trace levels of bacterial lipopolysaccharide prevent interferon-γ or tumor necrosis factor-α from enhancing mouse peritoneal macrophage respiratory burst capacity Journal of Immunology. 139: 1971-1977. PMID 3040860  1
1987 Nathan CF. Neutrophil activation on biological surfaces. Massive secretion of hydrogen peroxide in response to products of macrophages and lymphocytes Journal of Clinical Investigation. 80: 1550-1560. PMID 2445780  1
1986 Nathan CF. Peroxide and pteridine: a hypothesis on the regulation of macrophage antimicrobial activity by interferon gamma Interferon. 7: 125-143. PMID 3102389  1
1986 Tsunawaki S, Nathan CF. Release of arachidonate and reduction of oxygen. Independent metabolic bursts of the mouse peritoneal macrophage Journal of Biological Chemistry. 261: 11563-11570. PMID 3091592  1
1986 Nathan CF. Macrophage activation: some questions Annales De L"Institut Pasteur. Immunologie. 137: 345-351. PMID 3090928  1
1986 Nathan CF, Tsunawaki S. Secretion of toxic oxygen products by macrophages: regulatory cytokines and their effects on the oxidase Ciba Foundation Symposium. 118: 211-230. PMID 3089712  1
1986 Tsunawaki S, Nathan CF. Macrophage deactivation. Altered kinetic properties of superoxide-producing enzyme after exposure to tumor cell-conditioned medium Journal of Experimental Medicine. 164: 1319-1331. PMID 3020151  1
1985 Arrick BA, Griffo W, Cohn Z, Nathan C. Hydrogen peroxide from cellular metabolism of cystine: A requirement for lysis of murine tumor cells by vernolepin, a glutathione-depleting antineoplastic Journal of Clinical Investigation. 76: 567-574. PMID 3928682  1
1984 Arrick BA, Nathan CF. Glutathione Metabolism as a Determinant of Therapeutic Efficacy: A Review Cancer Research. 44: 4224-4232. PMID 6380705  1
1984 Tsunawaki S, Nathan CF. Enzymatic basis of macrophage activation. Kinetic analysis of superoxide production in lysates of resident and activated mouse peritoneal macrophages and granulocytes Journal of Biological Chemistry. 259: 4305-4312. PMID 6323464  1
1983 Arrick BA, Nathan CF, Cohn ZA. Inhibition of glutathione synthesis augments lysis of murine tumor cells by sulfhydryl-reactive antineoplastics. The Journal of Clinical Investigation. 71: 258-67. PMID 6401768  1
1983 Nathan CF. Mechanisms of macrophage antimicrobial activity Transactions of the Royal Society of Tropical Medicine and Hygiene. 77: 620-630. PMID 6362115 DOI: 10.1016/0035-9203(83)90190-6  1
1983 Adams DO, Nathan CF. Molecular mechanisms in tumor-cell killing by activated macrophages Immunology Today. 4: 166-170. DOI: 10.1016/0167-5699(83)90005-1  1
1982 Nathan CF, Klebanoff SJ. Augmentation of spontaneous macrophage-mediated cytolysis by eosinophil peroxidase Journal of Experimental Medicine. 155: 1291-1308. PMID 6802924  1
1982 Arrick BA, Nathan CF, Griffith OW, Cohn ZA. Glutathione depletion sensitizes tumor cells to oxidative cytolysis Journal of Biological Chemistry. 257: 1231-1237. PMID 6799503  1
1982 Nathan CF. Secretion of oxygen intermediates: Role in effector functions of activated macrophages Federation Proceedings. 41: 2206-2211. PMID 6281078  1
1981 Nathan CF, Cohn ZA. Antitumor effects of hydrogen peroxide in vivo Journal of Experimental Medicine. 154: 1539-1553. PMID 7299347  1
1981 Nathan CF, Arrick BA, Murray HW, DeSantis NM, Cohn ZA. Tumor cell anti-oxidant defenses. Inhibition of the glutathione redox cycle enhances macrophage-mediated cytolysis Journal of Experimental Medicine. 153: 766-782. PMID 7252413 DOI: 10.1084/jem.153.4.766  1
1980 Nathan C, Cohn Z. Role of oxygen-dependent mechanism in antibody-induced lysis of tumor cells by activated macrophages Journal of Experimental Medicine. 152: 198-208. PMID 6995553  1
1977 Nathan CF, Root RK. Hydrogen peroxide release from mouse peritoneal macrophages. Dependence on sequential activation and triggering Journal of Experimental Medicine. 146: 1648-1662. PMID 925614  1
1977 Nathan CF, Terry WD. Decreased phagocytosis by peritoneal macrophages from BCG-treated mice. Induction of the phagocytic defect in normal macrophages with BCG in vitro Cellular Immunology. 29: 295-311. PMID 324633 DOI: 10.1016/0008-8749(77)90324-0  1
1975 Nathan CF, Terry WD. Differential stimulation of murine lymphoma growth in vitro by normal and BCG activated macrophages Journal of Experimental Medicine. 142: 887-902. PMID 170358  1
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