Alexander R. Horswill, Ph.D. - Publications

Affiliations: 
2001 University of Wisconsin, Madison, Madison, WI 
 2005-2017 Microbiology University of Iowa, Iowa City, IA 
 2017- Immunology & Microbiology University of Colorado Anschutz Medical Campus, Denver, Aurora, CO 
Area:
Microbiology Biology
Website:
http://www.ucdenver.edu/academics/colleges/medicalschool/departments/ImmunologyMicrobiology/faculty/departmental/Pages/HORSWILL.aspx

122 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2019 Crosby HA, Tiwari N, Kwiecinski JM, Xu Z, Dykstra A, Jenul C, Fuentes EJ, Horswill AR. The Staphylococcus aureus ArlRS two-component system regulates virulence factor expression through MgrA. Molecular Microbiology. PMID 31618469 DOI: 10.1111/mmi.14404  0.52
2019 Grundstad ML, Parlet CP, Kwiecinski JM, Kavanaugh JS, Crosby HA, Cho YS, Heilmann K, Diekema DJ, Horswill AR. Quorum Sensing, Virulence, and Antibiotic Resistance of USA100 Methicillin-Resistant Staphylococcus aureus Isolates. Msphere. 4. PMID 31413175 DOI: 10.1128/mSphere.00553-19  0.52
2019 Kavanaugh JS, Flack CE, Lister J, Ricker EB, Ibberson CB, Jenul C, Moormeier DE, Delmain EA, Bayles KW, Horswill AR. Identification of Extracellular DNA-Binding Proteins in the Biofilm Matrix. Mbio. 10. PMID 31239382 DOI: 10.1128/mBio.01137-19  0.4
2019 Kwiecinski JM, Crosby HA, Valotteau C, Hippensteel JA, Nayak MK, Chauhan AK, Schmidt EP, Dufrêne YF, Horswill AR. Staphylococcus aureus adhesion in endovascular infections is controlled by the ArlRS-MgrA signaling cascade. Plos Pathogens. 15: e1007800. PMID 31116795 DOI: 10.1371/journal.ppat.1007800  0.52
2019 Borbón TY, Scorza BM, Clay GM, Lima Nobre de Queiroz F, Sariol AJ, Bowen JL, Chen Y, Zhanbolat B, Parlet CP, Valadares DG, Cassel SL, Nauseef WM, Horswill AR, Sutterwala FS, Wilson ME. Coinfection with Leishmania major and Staphylococcus aureus enhances the pathologic responses to both microbes through a pathway involving IL-17A. Plos Neglected Tropical Diseases. 13: e0007247. PMID 31107882 DOI: 10.1371/journal.pntd.0007247  0.4
2019 Kwiecinski JM, Jacobsson G, Horswill AR, Josefsson E, Jin T. Biofilm formation by Staphylococcus aureus clinical isolates correlates with the infection type. Infectious Diseases (London, England). 1-6. PMID 30985241 DOI: 10.1080/23744235.2019.1593499  0.4
2019 Tian X, Hellman J, Horswill AR, Crosby HA, Francis KP, Prakash A. Corrigendum: Elevated Gut Microbiome-Derived Propionate Levels Are Associated With Reduced Sterile Lung Inflammation and Bacterial Immunity in Mice. Frontiers in Microbiology. 10: 518. PMID 30972040 DOI: 10.3389/fmicb.2019.00518  0.52
2019 Parlet CP, Kavanaugh JS, Crosby HA, Raja HA, El-Elimat T, Todd DA, Pearce CJ, Cech NB, Oberlies NH, Horswill AR. Apicidin Attenuates MRSA Virulence through Quorum-Sensing Inhibition and Enhanced Host Defense. Cell Reports. 27: 187-198.e6. PMID 30943400 DOI: 10.1016/j.celrep.2019.03.018  0.52
2019 Parlet CP, Brown MM, Horswill AR. Commensal Staphylococci Influence Staphylococcus aureus Skin Colonization and Disease. Trends in Microbiology. PMID 30846311 DOI: 10.1016/j.tim.2019.01.008  0.4
2018 Trivedi U, Madsen JS, Everett J, Fell C, Russel J, Haaber J, Crosby HA, Horswill AR, Burmølle M, Rumbaugh KP, Sørensen SJ. coagulases are exploitable yet stable public goods in clinically relevant conditions. Proceedings of the National Academy of Sciences of the United States of America. PMID 30463950 DOI: 10.1073/pnas.1804850115  0.52
2018 Chen Y, Crosby HA, Oosthuysen WF, Diekema DJ, Kelley ST, Horswill AR. Draft Genome Sequence of USA100 Methicillin-Resistant Staphylococcus aureus Strain 209. Genome Announcements. 6. PMID 29301880 DOI: 10.1128/genomeA.01399-17  0.52
2017 Paharik AE, Parlet CP, Chung N, Todd DA, Rodriguez EI, Van Dyke MJ, Cech NB, Horswill AR. Coagulase-Negative Staphylococcal Strain Prevents Staphylococcus aureus Colonization and Skin Infection by Blocking Quorum Sensing. Cell Host & Microbe. 22: 746-756.e5. PMID 29199097 DOI: 10.1016/j.chom.2017.11.001  0.4
2017 Todd DA, Parlet CP, Crosby HA, Malone CL, Heilmann KP, Horswill AR, Cech NB. Targeting quorum sensing signal biosynthesis to fight antibiotic resistant infections: Ambuic acid as a model inhibitor. Antimicrobial Agents and Chemotherapy. PMID 28607020 DOI: 10.1128/AAC.00263-17  0.52
2017 Muhs A, Lyles JT, Parlet CP, Nelson K, Kavanaugh JS, Horswill AR, Quave CL. Virulence Inhibitors from Brazilian Peppertree Block Quorum Sensing and Abate Dermonecrosis in Skin Infection Models. Scientific Reports. 7: 42275. PMID 28186134 DOI: 10.1038/srep42275  0.4
2016 Paharik AE, Salgado-Pabon W, Meyerholz DK, White MJ, Schlievert PM, Horswill AR. The Spl Serine Proteases Modulate Staphylococcus aureus Protein Production and Virulence in a Rabbit Model of Pneumonia. Msphere. 1. PMID 27747296 DOI: 10.1128/mSphere.00208-16  0.52
2016 Gordon CP, Olson SD, Lister JL, Kavanaugh JS, Horswill AR. Truncated auto-inducing peptides as antagonists of Staphylococcus lugdunensis quorum sensing. Journal of Medicinal Chemistry. PMID 27585401 DOI: 10.1021/acs.jmedchem.6b00727  0.4
2016 Todd DA, Zich DB, Ettefagh KA, Kavanaugh JS, Horswill AR, Cech NB. Hybrid Quadrupole-Orbitrap mass spectrometry for quantitative measurement of quorum sensing inhibition. Journal of Microbiological Methods. PMID 27237773 DOI: 10.1016/j.mimet.2016.05.024  1
2016 Crosby HA, Schlievert PM, Merriman JA, King JM, Salgado-Pabón W, Horswill AR. The Staphylococcus aureus Global Regulator MgrA Modulates Clumping and Virulence by Controlling Surface Protein Expression. Plos Pathogens. 12: e1005604. PMID 27144398 DOI: 10.1371/journal.ppat.1005604  0.52
2016 Kavanaugh JS, Horswill AR. Impact of environmental cues on Staphylococcal quorum-sensing and biofilm development. The Journal of Biological Chemistry. PMID 27129223 DOI: 10.1074/jbc.R116.722710  0.4
2016 Ibberson CB, Parlet CP, Kwiecinski J, Crosby HA, Meyerholz DK, Horswill AR. Hyaluronan modulation impacts Staphylococcus aureus biofilm infection. Infection and Immunity. PMID 27068096 DOI: 10.1128/IAI.01418-15  1
2016 Herrera A, Vu BG, Stach CS, Merriman JA, Horswill AR, Salgado-Pabon W, Schlievert PM. Staphylococcus aureus β-Toxin Mutants Are Defective in Biofilm Ligase and Sphingomyelinase Activity, and Causation of Infective Endocarditis/Sepsis. Biochemistry. PMID 27015018 DOI: 10.1021/acs.biochem.6b00083  1
2016 Mlynek KD, Callahan MT, Shimkevitch AV, Farmer JT, Endres JL, Marchand M, Bayles KW, Horswill AR, Kaplan JB. Effects of Low-Dose Amoxicillin on Staphylococcus aureus USA300 Biofilms. Antimicrobial Agents and Chemotherapy. PMID 26856828 DOI: 10.1128/AAC.02070-15  1
2015 Britton ER, Ibberson CB, Horswill AR, Cech NB. A new mass spectrometry based bioassay for the direct assessment of hyaluronidase activity and inhibition. Journal of Microbiological Methods. 119: 163-167. PMID 26519769 DOI: 10.1016/j.mimet.2015.10.019  1
2015 Scherr TD, Hanke ML, Huang O, James DB, Horswill AR, Bayles KW, Fey PD, Torres VJ, Kielian T. Staphylococcus aureus Biofilms Induce Macrophage Dysfunction Through Leukocidin AB and Alpha-Toxin. Mbio. 6. PMID 26307164 DOI: 10.1128/mBio.01021-15  1
2015 Quave CL, Lyles JT, Kavanaugh JS, Nelson K, Parlet CP, Crosby HA, Heilmann KP, Horswill AR. Castanea sativa (European Chestnut) Leaf Extracts Rich in Ursene and Oleanene Derivatives Block Staphylococcus aureus Virulence and Pathogenesis without Detectable Resistance. Plos One. 10: e0136486. PMID 26295163 DOI: 10.1371/journal.pone.0136486  1
2015 Decker R, Burdelski C, Zobiak M, Büttner H, Franke G, Christner M, Saß K, Zobiak B, Henke HA, Horswill AR, Bischoff M, Bur S, Hartmann T, Schaeffer CR, Fey PD, et al. An 18 kDa scaffold protein is critical for Staphylococcus epidermidis biofilm formation. Plos Pathogens. 11: e1004735. PMID 25799153 DOI: 10.1371/journal.ppat.1004735  1
2015 Daly SM, Elmore BO, Kavanaugh JS, Triplett KD, Figueroa M, Raja HA, El-Elimat T, Crosby HA, Femling JK, Cech NB, Horswill AR, Oberlies NH, Hall PR. ω-Hydroxyemodin limits staphylococcus aureus quorum sensing-mediated pathogenesis and inflammation. Antimicrobial Agents and Chemotherapy. 59: 2223-35. PMID 25645827 DOI: 10.1128/AAC.04564-14  1
2015 Mootz JM, Benson MA, Heim CE, Crosby HA, Kavanaugh JS, Dunman PM, Kielian T, Torres VJ, Horswill AR. Rot is a key regulator of Staphylococcus aureus biofilm formation. Molecular Microbiology. 96: 388-404. PMID 25612137 DOI: 10.1111/mmi.12943  1
2015 Parlet CP, Kavanaugh JS, Horswill AR, Schlueter AJ. Chronic ethanol feeding increases the severity of Staphylococcus aureus skin infections by altering local host defenses. Journal of Leukocyte Biology. 97: 769-78. PMID 25605871 DOI: 10.1189/jlb.4A0214-092R  1
2015 Schaeffer CR, Woods KM, Longo GM, Kiedrowski MR, Paharik AE, Büttner H, Christner M, Boissy RJ, Horswill AR, Rohde H, Fey PD. Accumulation-associated protein enhances Staphylococcus epidermidis biofilm formation under dynamic conditions and is required for infection in a rat catheter model. Infection and Immunity. 83: 214-26. PMID 25332125 DOI: 10.1128/IAI.02177-14  1
2014 Lister JL, Horswill AR. Staphylococcus aureus biofilms: recent developments in biofilm dispersal. Frontiers in Cellular and Infection Microbiology. 4: 178. PMID 25566513 DOI: 10.3389/fcimb.2014.00178  1
2014 Quave CL, Horswill AR. Flipping the switch: tools for detecting small molecule inhibitors of staphylococcal virulence. Frontiers in Microbiology. 5: 706. PMID 25566220 DOI: 10.3389/fmicb.2014.00706  1
2014 Abou Alaiwa MH, Reznikov LR, Gansemer ND, Sheets KA, Horswill AR, Stoltz DA, Zabner J, Welsh MJ. pH modulates the activity and synergism of the airway surface liquid antimicrobials β-defensin-3 and LL-37. Proceedings of the National Academy of Sciences of the United States of America. 111: 18703-8. PMID 25512526 DOI: 10.1073/pnas.1422091112  1
2014 Moormeier DE, Bose JL, Horswill AR, Bayles KW. Temporal and stochastic control of Staphylococcus aureus biofilm development. Mbio. 5: e01341-14. PMID 25316695 DOI: 10.1128/mBio.01341-14  1
2014 DeLeon S, Clinton A, Fowler H, Everett J, Horswill AR, Rumbaugh KP. Synergistic interactions of Pseudomonas aeruginosa and Staphylococcus aureus in an in vitro wound model. Infection and Immunity. 82: 4718-28. PMID 25156721 DOI: 10.1128/IAI.02198-14  1
2014 Olson ME, Todd DA, Schaeffer CR, Paharik AE, Van Dyke MJ, Büttner H, Dunman PM, Rohde H, Cech NB, Fey PD, Horswill AR. Staphylococcus epidermidis agr quorum-sensing system: signal identification, cross talk, and importance in colonization. Journal of Bacteriology. 196: 3482-93. PMID 25070736 DOI: 10.1128/JB.01882-14  1
2014 Ibberson CB, Jones CL, Singh S, Wise MC, Hart ME, Zurawski DV, Horswill AR. Staphylococcus aureus hyaluronidase is a CodY-regulated virulence factor. Infection and Immunity. 82: 4253-64. PMID 25069977 DOI: 10.1128/IAI.01710-14  1
2014 Sully EK, Malachowa N, Elmore BO, Alexander SM, Femling JK, Gray BM, DeLeo FR, Otto M, Cheung AL, Edwards BS, Sklar LA, Horswill AR, Hall PR, Gresham HD. Selective chemical inhibition of agr quorum sensing in Staphylococcus aureus promotes host defense with minimal impact on resistance. Plos Pathogens. 10: e1004174. PMID 24945495 DOI: 10.1371/journal.ppat.1004174  1
2014 Figueroa M, Jarmusch AK, Raja HA, El-Elimat T, Kavanaugh JS, Horswill AR, Cooks RG, Cech NB, Oberlies NH. Polyhydroxyanthraquinones as quorum sensing inhibitors from the guttates of Penicillium restrictum and their analysis by desorption electrospray ionization mass spectrometry. Journal of Natural Products. 77: 1351-8. PMID 24911880 DOI: 10.1021/np5000704  1
2014 Flack CE, Zurek OW, Meishery DD, Pallister KB, Malone CL, Horswill AR, Voyich JM. Differential regulation of staphylococcal virulence by the sensor kinase SaeS in response to neutrophil-derived stimuli. Proceedings of the National Academy of Sciences of the United States of America. 111: E2037-45. PMID 24782537 DOI: 10.1073/pnas.1322125111  1
2014 Kiedrowski MR, Crosby HA, Hernandez FJ, Malone CL, McNamara JO, Horswill AR. Staphylococcus aureus Nuc2 is a functional, surface-attached extracellular nuclease. Plos One. 9: e95574. PMID 24752186 DOI: 10.1371/journal.pone.0095574  1
2014 Sommerfeld Ross S, Tu MH, Falsetta ML, Ketterer MR, Kiedrowski MR, Horswill AR, Apicella MA, Reinhardt JM, Fiegel J. Quantification of confocal images of biofilms grown on irregular surfaces. Journal of Microbiological Methods. 100: 111-20. PMID 24632515 DOI: 10.1016/j.mimet.2014.02.020  1
2014 Hernandez FJ, Huang L, Olson ME, Powers KM, Hernandez LI, Meyerholz DK, Thedens DR, Behlke MA, Horswill AR, McNamara JO. Noninvasive imaging of Staphylococcus aureus infections with a nuclease-activated probe. Nature Medicine. 20: 301-6. PMID 24487433 DOI: 10.1038/nm.3460  1
2014 White MJ, Boyd JM, Horswill AR, Nauseef WM. Phosphatidylinositol-specific phospholipase C contributes to survival of Staphylococcus aureus USA300 in human blood and neutrophils. Infection and Immunity. 82: 1559-71. PMID 24452683 DOI: 10.1128/IAI.01168-13  1
2014 Pang YY, Schwartz J, Bloomberg S, Boyd JM, Horswill AR, Nauseef WM. Methionine sulfoxide reductases protect against oxidative stress in Staphylococcus aureus encountering exogenous oxidants and human neutrophils. Journal of Innate Immunity. 6: 353-64. PMID 24247266 DOI: 10.1159/000355915  1
2014 Olson ME, Horswill AR. Bacteriophage Transduction in Staphylococcus epidermidis. Methods in Molecular Biology (Clifton, N.J.). 1106: 167-72. PMID 24222465 DOI: 10.1007/978-1-62703-736-5_15  1
2014 Zurek OW, Nygaard TK, Watkins RL, Pallister KB, Torres VJ, Horswill AR, Voyich JM. The role of innate immunity in promoting SaeR/S-mediated virulence in Staphylococcus aureus. Journal of Innate Immunity. 6: 21-30. PMID 23816635 DOI: 10.1159/000351200  1
2013 Snowden JN, Beaver M, Beenken K, Smeltzer M, Horswill AR, Kielian T. Staphylococcus aureus sarA regulates inflammation and colonization during central nervous system biofilm formation. Plos One. 8: e84089. PMID 24386336 DOI: 10.1371/journal.pone.0084089  1
2013 Walker JN, Crosby HA, Spaulding AR, Salgado-Pabón W, Malone CL, Rosenthal CB, Schlievert PM, Boyd JM, Horswill AR. The Staphylococcus aureus ArlRS two-component system is a novel regulator of agglutination and pathogenesis. Plos Pathogens. 9: e1003819. PMID 24367264 DOI: 10.1371/journal.ppat.1003819  1
2013 Cech NB, Horswill AR. Small-molecule quorum quenchers to prevent Staphylococcus aureus infection. Future Microbiology. 8: 1511-4. PMID 24266350 DOI: 10.2217/fmb.13.134  1
2013 Chiu IM, Heesters BA, Ghasemlou N, Von Hehn CA, Zhao F, Tran J, Wainger B, Strominger A, Muralidharan S, Horswill AR, Bubeck Wardenburg J, Hwang SW, Carroll MC, Woolf CJ. Bacteria activate sensory neurons that modulate pain and inflammation. Nature. 501: 52-7. PMID 23965627 DOI: 10.1038/nature12479  1
2013 Salgado-Pabón W, Breshears L, Spaulding AR, Merriman JA, Stach CS, Horswill AR, Peterson ML, Schlievert PM. Superantigens are critical for Staphylococcus aureus Infective endocarditis, sepsis, and acute kidney injury. Mbio. 4. PMID 23963178 DOI: 10.1128/mBio.00494-13  1
2013 Yu J, Madsen ML, Carruthers MD, Phillips GJ, Kavanaugh JS, Boyd JM, Horswill AR, Minion FC. Analysis of autoinducer-2 quorum sensing in Yersinia pestis. Infection and Immunity. 81: 4053-62. PMID 23959719 DOI: 10.1128/IAI.00880-13  1
2013 Spaulding AR, Salgado-Pabón W, Kohler PL, Horswill AR, Leung DY, Schlievert PM. Staphylococcal and streptococcal superantigen exotoxins. Clinical Microbiology Reviews. 26: 422-47. PMID 23824366 DOI: 10.1128/CMR.00104-12  1
2013 Mootz JM, Malone CL, Shaw LN, Horswill AR. Staphopains modulate Staphylococcus aureus biofilm integrity. Infection and Immunity. 81: 3227-38. PMID 23798534 DOI: 10.1128/IAI.00377-13  1
2013 Olson ME, Horswill AR. Staphylococcus aureus osteomyelitis: bad to the bone. Cell Host & Microbe. 13: 629-31. PMID 23768487 DOI: 10.1016/j.chom.2013.05.015  1
2013 Junio HA, Todd DA, Ettefagh KA, Ehrmann BM, Kavanaugh JS, Horswill AR, Cech NB. Quantitative analysis of autoinducing peptide I (AIP-I) from Staphylococcus aureus cultures using ultrahigh performance liquid chromatography-high resolving power mass spectrometry. Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences. 930: 7-12. PMID 23703543 DOI: 10.1016/j.jchromb.2013.04.019  1
2013 LaRock CN, Yu J, Horswill AR, Parsek MR, Minion FC. Transcriptome analysis of acyl-homoserine lactone-based quorum sensing regulation in Yersinia pestis [corrected]. Plos One. 8: e62337. PMID 23620823 DOI: 10.1371/journal.pone.0062337  1
2013 Moormeier DE, Endres JL, Mann EE, Sadykov MR, Horswill AR, Rice KC, Fey PD, Bayles KW. Use of microfluidic technology to analyze gene expression during Staphylococcus aureus biofilm formation reveals distinct physiological niches Applied and Environmental Microbiology. 79: 3413-3424. PMID 23524683 DOI: 10.1128/AEM.00395-13  1
2013 Hall PR, Elmore BO, Spang CH, Alexander SM, Manifold-Wheeler BC, Castleman MJ, Daly SM, Peterson MM, Sully EK, Femling JK, Otto M, Horswill AR, Timmins GS, Gresham HD. Nox2 modification of LDL is essential for optimal apolipoprotein B-mediated control of agr type III Staphylococcus aureus quorum-sensing. Plos Pathogens. 9: e1003166. PMID 23459693 DOI: 10.1371/journal.ppat.1003166  1
2013 Olson ME, King JM, Yahr TL, Horswill AR. Sialic acid catabolism in Staphylococcus aureus. Journal of Bacteriology. 195: 1779-88. PMID 23396916 DOI: 10.1128/JB.02294-12  1
2013 Olson ME, Nygaard TK, Ackermann L, Watkins RL, Zurek OW, Pallister KB, Griffith S, Kiedrowski MR, Flack CE, Kavanaugh JS, Kreiswirth BN, Horswill AR, Voyich JM. Staphylococcus aureus nuclease is an SaeRS-dependent virulence factor. Infection and Immunity. 81: 1316-24. PMID 23381999 DOI: 10.1128/IAI.01242-12  1
2013 Abdelhady W, Bayer AS, Seidl K, Nast CC, Kiedrowski MR, Horswill AR, Yeaman MR, Xiong YQ. Reduced vancomycin susceptibility in an in vitro catheter-related biofilm model correlates with poor therapeutic outcomes in experimental endocarditis due to methicillin-resistant Staphylococcus aureus. Antimicrobial Agents and Chemotherapy. 57: 1447-54. PMID 23295925 DOI: 10.1128/AAC.02073-12  1
2013 Kolar SL, Ibarra JA, Rivera FE, Mootz JM, Davenport JE, Stevens SM, Horswill AR, Shaw LN. Extracellular proteases are key mediators of Staphylococcus aureus virulence via the global modulation of virulence-determinant stability. Microbiologyopen. 2: 18-34. PMID 23233325 DOI: 10.1002/mbo3.55  1
2013 Thoendel M, Horswill AR. Random mutagenesis and topology analysis of the autoinducing peptide biosynthesis proteins in Staphylococcus aureus. Molecular Microbiology. 87: 318-37. PMID 23216863 DOI: 10.1111/mmi.12100  1
2012 Zielinska AK, Beenken KE, Mrak LN, Spencer HJ, Post GR, Skinner RA, Tackett AJ, Horswill AR, Smeltzer MS. sarA-mediated repression of protease production plays a key role in the pathogenesis of Staphylococcus aureus USA300 isolates. Molecular Microbiology. 86: 1183-96. PMID 23075270 DOI: 10.1111/mmi.12048  1
2012 Walker JN, Horswill AR. A coverslip-based technique for evaluating Staphylococcus aureus biofilm formation on human plasma. Frontiers in Cellular and Infection Microbiology. 2: 39. PMID 22919630 DOI: 10.3389/fcimb.2012.00039  1
2012 Kaplan JB, Izano EA, Gopal P, Karwacki MT, Kim S, Bose JL, Bayles KW, Horswill AR. Low levels of β-lactam antibiotics induce extracellular DNA release and biofilm formation in Staphylococcus aureus. Mbio. 3: e00198-12. PMID 22851659 DOI: 10.1128/mBio.00198-12  1
2012 Laarman AJ, Mijnheer G, Mootz JM, van Rooijen WJ, Ruyken M, Malone CL, Heezius EC, Ward R, Milligan G, van Strijp JA, de Haas CJ, Horswill AR, van Kessel KP, Rooijakkers SH. Staphylococcus aureus Staphopain A inhibits CXCR2-dependent neutrophil activation and chemotaxis. The Embo Journal. 31: 3607-19. PMID 22850671 DOI: 10.1038/emboj.2012.212  1
2012 Boles BR, Horswill AR. Swimming cells promote a dynamic environment within biofilms. Proceedings of the National Academy of Sciences of the United States of America. 109: 12848-9. PMID 22847434 DOI: 10.1073/pnas.1210297109  1
2012 Cech NB, Junio HA, Ackermann LW, Kavanaugh JS, Horswill AR. Quorum quenching and antimicrobial activity of goldenseal (Hydrastis canadensis) against methicillin-resistant Staphylococcus aureus (MRSA). Planta Medica. 78: 1556-61. PMID 22814821 DOI: 10.1055/s-0032-1315042  1
2012 Pezzulo AA, Tang XX, Hoegger MJ, Alaiwa MH, Ramachandran S, Moninger TO, Karp PH, Wohlford-Lenane CL, Haagsman HP, van Eijk M, Bánfi B, Horswill AR, Stoltz DA, McCray PB, Welsh MJ, et al. Reduced airway surface pH impairs bacterial killing in the porcine cystic fibrosis lung. Nature. 487: 109-13. PMID 22763554 DOI: 10.1038/nature11130  1
2012 Nygaard TK, Pallister KB, DuMont AL, DeWald M, Watkins RL, Pallister EQ, Malone C, Griffith S, Horswill AR, Torres VJ, Voyich JM. Alpha-toxin induces programmed cell death of human T cells, B cells, and monocytes during USA300 infection. Plos One. 7: e36532. PMID 22574180 DOI: 10.1371/journal.pone.0036532  1
2012 Gonzalez DJ, Okumura CY, Hollands A, Kersten R, Akong-Moore K, Pence MA, Malone CL, Derieux J, Moore BS, Horswill AR, Dixon JE, Dorrestein PC, Nizet V. Novel phenol-soluble modulin derivatives in community-associated methicillin-resistant Staphylococcus aureus identified through imaging mass spectrometry. The Journal of Biological Chemistry. 287: 13889-98. PMID 22371493 DOI: 10.1074/jbc.M112.349860  1
2012 Hernandez FJ, Stockdale KR, Huang L, Horswill AR, Behlke MA, McNamara JO. Degradation of nuclease-stabilized RNA oligonucleotides in Mycoplasma-contaminated cell culture media. Nucleic Acid Therapeutics. 22: 58-68. PMID 22229275 DOI: 10.1089/nat.2011.0316  1
2011 Kiedrowski MR, Horswill AR. New approaches for treating staphylococcal biofilm infections. Annals of the New York Academy of Sciences. 1241: 104-21. PMID 22191529 DOI: 10.1111/j.1749-6632.2011.06281.x  1
2011 Kavanaugh JS, Gakhar L, Horswill AR. The structure of LsrB from Yersinia pestis complexed with autoinducer-2. Acta Crystallographica. Section F, Structural Biology and Crystallization Communications. 67: 1501-5. PMID 22139152 DOI: 10.1107/S1744309111042953  1
2011 Kiedrowski MR, Kavanaugh JS, Malone CL, Mootz JM, Voyich JM, Smeltzer MS, Bayles KW, Horswill AR. Nuclease modulates biofilm formation in community-associated methicillin-resistant Staphylococcus aureus. Plos One. 6: e26714. PMID 22096493 DOI: 10.1371/journal.pone.0026714  1
2011 Wörmann ME, Reichmann NT, Malone CL, Horswill AR, Gründling A. Proteolytic cleavage inactivates the Staphylococcus aureus lipoteichoic acid synthase. Journal of Bacteriology. 193: 5279-91. PMID 21784926 DOI: 10.1128/JB.00369-11  1
2011 Boles BR, Horswill AR. Staphylococcal biofilm disassembly. Trends in Microbiology. 19: 449-55. PMID 21784640 DOI: 10.1016/j.tim.2011.06.004  1
2011 Lin YC, Anderson MJ, Kohler PL, Strandberg KL, Olson ME, Horswill AR, Schlievert PM, Peterson ML. Proinflammatory exoprotein characterization of toxic shock syndrome Staphylococcus aureus. Biochemistry. 50: 7157-67. PMID 21749039 DOI: 10.1021/bi200435n  1
2011 Thurlow LR, Hanke ML, Fritz T, Angle A, Aldrich A, Williams SH, Engebretsen IL, Bayles KW, Horswill AR, Kielian T. Staphylococcus aureus biofilms prevent macrophage phagocytosis and attenuate inflammation in vivo. Journal of Immunology (Baltimore, Md. : 1950). 186: 6585-96. PMID 21525381 DOI: 10.4049/jimmunol.1002794  1
2011 Laarman AJ, Ruyken M, Malone CL, van Strijp JA, Horswill AR, Rooijakkers SH. Staphylococcus aureus metalloprotease aureolysin cleaves complement C3 to mediate immune evasion. Journal of Immunology (Baltimore, Md. : 1950). 186: 6445-53. PMID 21502375 DOI: 10.4049/jimmunol.1002948  1
2011 Kirchdoerfer RN, Garner AL, Flack CE, Mee JM, Horswill AR, Janda KD, Kaufmann GF, Wilson IA. Structural basis for ligand recognition and discrimination of a quorum-quenching antibody. The Journal of Biological Chemistry. 286: 17351-8. PMID 21454495 DOI: 10.1074/jbc.M111.231258  1
2011 Thoendel M, Kavanaugh JS, Flack CE, Horswill AR. Peptide signaling in the staphylococci. Chemical Reviews. 111: 117-51. PMID 21174435 DOI: 10.1021/cr100370n  1
2011 Hammond AA, Miller KG, Kruczek CJ, Dertien J, Colmer-Hamood JA, Griswold JA, Horswill AR, Hamood AN. An in vitro biofilm model to examine the effect of antibiotic ointments on biofilms produced by burn wound bacterial isolates. Burns : Journal of the International Society For Burn Injuries. 37: 312-21. PMID 21130579 DOI: 10.1016/j.burns.2010.09.017  1
2011 Boles BR, Horswill AR. The Cyclization of Peptides and Proteins with Inteins Protein Engineering Handbook, Volume 1 &Amp; Volume 2. 1: 391-407. DOI: 10.1002/9783527634026.ch15  1
2010 Berends ET, Horswill AR, Haste NM, Monestier M, Nizet V, von Köckritz-Blickwede M. Nuclease expression by Staphylococcus aureus facilitates escape from neutrophil extracellular traps. Journal of Innate Immunity. 2: 576-86. PMID 20829609 DOI: 10.1159/000319909  1
2010 Pang YY, Schwartz J, Thoendel M, Ackermann LW, Horswill AR, Nauseef WM. agr-Dependent interactions of Staphylococcus aureus USA300 with human polymorphonuclear neutrophils. Journal of Innate Immunity. 2: 546-59. PMID 20829608 DOI: 10.1159/000319855  1
2010 Beenken KE, Mrak LN, Griffin LM, Zielinska AK, Shaw LN, Rice KC, Horswill AR, Bayles KW, Smeltzer MS. Epistatic relationships between sarA and agr in Staphylococcus aureus biofilm formation. Plos One. 5: e10790. PMID 20520723 DOI: 10.1371/journal.pone.0010790  1
2010 Stoltz DA, Meyerholz DK, Pezzulo AA, Ramachandran S, Rogan MP, Davis GJ, Hanfland RA, Wohlford-Lenane C, Dohrn CL, Bartlett JA, Nelson GA, Chang EH, Taft PJ, Ludwig PS, Estin M, ... ... Horswill AR, et al. Cystic fibrosis pigs develop lung disease and exhibit defective bacterial eradication at birth. Science Translational Medicine. 2: 29ra31. PMID 20427821 DOI: 10.1126/scitranslmed.3000928  1
2010 Boles BR, Thoendel M, Roth AJ, Horswill AR. Identification of genes involved in polysaccharide-independent Staphylococcus aureus biofilm formation. Plos One. 5: e10146. PMID 20418950 DOI: 10.1371/journal.pone.0010146  1
2010 Thoendel M, Horswill AR. Biosynthesis of peptide signals in gram-positive bacteria. Advances in Applied Microbiology. 71: 91-112. PMID 20378052 DOI: 10.1016/S0065-2164(10)71004-2  1
2010 Lauderdale KJ, Malone CL, Boles BR, Morcuende J, Horswill AR. Biofilm dispersal of community-associated methicillin-resistant Staphylococcus aureus on orthopedic implant material. Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society. 28: 55-61. PMID 19610092 DOI: 10.1002/jor.20943  1
2009 Thoendel M, Horswill AR. Identification of Staphylococcus aureus AgrD residues required for autoinducing peptide biosynthesis. The Journal of Biological Chemistry. 284: 21828-38. PMID 19520867 DOI: 10.1074/jbc.M109.031757  1
2009 Mann EE, Rice KC, Boles BR, Endres JL, Ranjit D, Chandramohan L, Tsang LH, Smeltzer MS, Horswill AR, Bayles KW. Modulation of eDNA release and degradation affects Staphylococcus aureus biofilm maturation. Plos One. 4: e5822. PMID 19513119 DOI: 10.1371/journal.pone.0005822  1
2009 Malone CL, Boles BR, Lauderdale KJ, Thoendel M, Kavanaugh JS, Horswill AR. Fluorescent reporters for Staphylococcus aureus. Journal of Microbiological Methods. 77: 251-60. PMID 19264102 DOI: 10.1016/j.mimet.2009.02.011  1
2009 Lauderdale KJ, Boles BR, Cheung AL, Horswill AR. Interconnections between Sigma B, agr, and proteolytic activity in Staphylococcus aureus biofilm maturation. Infection and Immunity. 77: 1623-35. PMID 19188357 DOI: 10.1128/IAI.01036-08  1
2008 Horswill AR, Nauseef WM. Host interception of bacterial communication signals. Cell Host & Microbe. 4: 507-9. PMID 19064249 DOI: 10.1016/j.chom.2008.11.003  1
2008 Boles BR, Horswill AR. Agr-mediated dispersal of Staphylococcus aureus biofilms. Plos Pathogens. 4: e1000052. PMID 18437240 DOI: 10.1371/journal.ppat.1000052  1
2007 Malone CL, Boles BR, Horswill AR. Biosynthesis of Staphylococcus aureus autoinducing peptides by using the synechocystis DnaB mini-intein. Applied and Environmental Microbiology. 73: 6036-44. PMID 17693565 DOI: 10.1128/AEM.00912-07  1
2007 Kavanaugh JS, Thoendel M, Horswill AR. A role for type I signal peptidase in Staphylococcus aureus quorum sensing. Molecular Microbiology. 65: 780-98. PMID 17608791 DOI: 10.1111/j.1365-2958.2007.05830.x  1
2007 Cheng L, Naumann TA, Horswill AR, Hong SJ, Venters BJ, Tomsho JW, Benkovic SJ, Keiler KC. Discovery of antibacterial cyclic peptides that inhibit the ClpXP protease. Protein Science : a Publication of the Protein Society. 16: 1535-42. PMID 17600141 DOI: 10.1110/ps.072933007  1
2007 Horswill AR, Stoodley P, Stewart PS, Parsek MR. The effect of the chemical, biological, and physical environment on quorum sensing in structured microbial communities. Analytical and Bioanalytical Chemistry. 387: 371-80. PMID 17047948 DOI: 10.1007/s00216-006-0720-y  1
2006 Horswill AR, Benkovic SJ. Identifying small-molecule modulators of protein-protein interactions. Current Protocols in Protein Science / Editorial Board, John E. Coligan ... [Et Al.]. Unit 19.15. PMID 18429304 DOI: 10.1002/0471140864.ps1915s46  1
2005 Horswill AR, Benkovic SJ. Cyclic peptides, a chemical genetics tool for biologists. Cell Cycle (Georgetown, Tex.). 4: 552-5. PMID 15876867  1
2004 Horswill AR, Savinov SN, Benkovic SJ. A systematic method for identifying small-molecule modulators of protein-protein interactions. Proceedings of the National Academy of Sciences of the United States of America. 101: 15591-6. PMID 15498867 DOI: 10.1073/pnas.0406999101  1
2004 Horswill AR, Naumann TA, Benkovic SJ. Using incremental truncation to create libraries of hybrid enzymes. Methods in Enzymology. 388: 50-60. PMID 15289061 DOI: 10.1016/S0076-6879(04)88006-6  1
2004 Lewis JA, Horswill AR, Schwem BE, Escalante-Semerena JC. The Tricarballylate utilization (tcuRABC) genes of Salmonella enterica serovar Typhimurium LT2. Journal of Bacteriology. 186: 1629-37. PMID 14996793 DOI: 10.1128/JB.186.6.1629-1637.2004  1
2004 Saraf MC, Horswill AR, Benkovic SJ, Maranas CD. FamClash: a method for ranking the activity of engineered enzymes. Proceedings of the National Academy of Sciences of the United States of America. 101: 4142-7. PMID 14981242 DOI: 10.1073/pnas.0400065101  1
2003 Gulick AM, Starai VJ, Horswill AR, Homick KM, Escalante-Semerena JC. The 1.75 A crystal structure of acetyl-CoA synthetase bound to adenosine-5'-propylphosphate and coenzyme A. Biochemistry. 42: 2866-73. PMID 12627952 DOI: 10.1021/bi0271603  1
2002 Fonseca MV, Buan NR, Horswill AR, Rayment I, Escalante-Semerena JC. The ATP:Co(I)rrinoid adenosyltransferase (CobA) enzyme of Salmonella enterica requires the 2'-OH group of ATP for function and yields inorganic triphosphate as its reaction byproduct. The Journal of Biological Chemistry. 277: 33127-31. PMID 12080060 DOI: 10.1074/jbc.M203893200  1
2002 Horswill AR, Escalante-Semerena JC. Characterization of the propionyl-CoA synthetase (PrpE) enzyme of Salmonella enterica: residue Lys592 is required for propionyl-AMP synthesis. Biochemistry. 41: 2379-87. PMID 11841231 DOI: 10.1021/bi015647q  1
2002 Gulick AM, Horswill AR, Thoden JB, Escalante-Semerena JC, Rayment I. Pentaerythritol propoxylate: a new crystallization agent and cryoprotectant induces crystal growth of 2-methylcitrate dehydratase. Acta Crystallographica. Section D, Biological Crystallography. 58: 306-9. PMID 11807258 DOI: 10.1107/S0907444901018832  1
2001 Horswill AR, Dudding AR, Escalante-Semerena JC. Studies of propionate toxicity in Salmonella enterica identify 2-methylcitrate as a potent inhibitor of cell growth. The Journal of Biological Chemistry. 276: 19094-101. PMID 11376009 DOI: 10.1074/jbc.M100244200  1
2001 Ciche TA, Bintrim SB, Horswill AR, Ensign JC. A Phosphopantetheinyl transferase homolog is essential for Photorhabdus luminescens to support growth and reproduction of the entomopathogenic nematode Heterorhabditis bacteriophora. Journal of Bacteriology. 183: 3117-26. PMID 11325940 DOI: 10.1128/JB.183.10.3117-3126.2001  1
2001 Horswill AR, Escalante-Semerena JC. In vitro conversion of propionate to pyruvate by Salmonella enterica enzymes: 2-methylcitrate dehydratase (PrpD) and aconitase Enzymes catalyze the conversion of 2-methylcitrate to 2-methylisocitrate. Biochemistry. 40: 4703-13. PMID 11294638 DOI: 10.1021/bi015503b  1
1999 Horswill AR, Escalante-Semerena JC. Salmonella typhimurium LT2 catabolizes propionate via the 2-methylcitric acid cycle. Journal of Bacteriology. 181: 5615-23. PMID 10482501  1
1999 Horswill AR, Escalante-Semerena JC. The prpE gene of Salmonella typhimurium LT2 encodes propionyl-CoA synthetase. Microbiology (Reading, England). 145: 1381-8. PMID 10411265 DOI: 10.1099/13500872-145-6-1381  1
1998 Tsang AW, Horswill AR, Escalante-Semerena JC. Studies of regulation of expression of the propionate (prpBCDE) operon provide insights into how Salmonella typhimurium LT2 integrates its 1,2-propanediol and propionate catabolic pathways. Journal of Bacteriology. 180: 6511-8. PMID 9851993  1
1997 Horswill AR, Escalante-Semerena JC. Propionate catabolism in Salmonella typhimurium LT2: two divergently transcribed units comprise the prp locus at 8.5 centisomes, prpR encodes a member of the sigma-54 family of activators, and the prpBCDE genes constitute an operon. Journal of Bacteriology. 179: 928-40. PMID 9006051  1
1995 Rondon MR, Horswill AR, Escalante-Semerena JC. DNA polymerase I function is required for the utilization of ethanolamine, 1,2-propanediol, and propionate by Salmonella typhimurium LT2. Journal of Bacteriology. 177: 7119-24. PMID 8522518  1
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