| Year |
Citation |
Score |
| 2019 |
Grosenbach DW, Hruby DE. Preliminary Screening and In Vitro Confirmation of Orthopoxvirus Antivirals. Methods in Molecular Biology (Clifton, N.J.). 2023: 143-155. PMID 31240676 DOI: 10.1007/978-1-4939-9593-6_9 |
0.357 |
|
| 2015 |
Berhanu A, Prigge JT, Silvera PM, Honeychurch KM, Hruby DE, Grosenbach DW. Treatment with the smallpox antiviral tecovirimat (ST-246) alone or in combination with ACAM2000 vaccination is effective as a postsymptomatic therapy for monkeypox virus infection. Antimicrobial Agents and Chemotherapy. 59: 4296-300. PMID 25896687 DOI: 10.1128/Aac.00208-15 |
0.352 |
|
| 2015 |
Duraffour S, Lorenzo MM, Zöller G, Topalis D, Grosenbach D, Hruby DE, Andrei G, Blasco R, Meyer H, Snoeck R. ST-246 is a key antiviral to inhibit the viral F13L phospholipase, one of the essential proteins for orthopoxvirus wrapping. The Journal of Antimicrobial Chemotherapy. 70: 1367-80. PMID 25630650 DOI: 10.1093/jac/dku545 |
0.322 |
|
| 2013 |
Byrd CM, Grosenbach DW, Hruby DE. Antiviral options for biodefense. Current Opinion in Virology. 3: 537-41. PMID 23773331 DOI: 10.1016/J.Coviro.2013.05.020 |
0.639 |
|
| 2013 |
Byrd CM, Grosenbach DW, Berhanu A, Dai D, Jones KF, Cardwell KB, Schneider C, Yang G, Tyavanagimatt S, Harver C, Wineinger KA, Page J, Stavale E, Stone MA, Fuller KP, ... ... Hruby DE, et al. Novel benzoxazole inhibitor of dengue virus replication that targets the NS3 helicase. Antimicrobial Agents and Chemotherapy. 57: 1902-12. PMID 23403421 DOI: 10.1128/Aac.02251-12 |
0.713 |
|
| 2013 |
Santos-Fernandes É, Beltrame CO, Byrd CM, Cardwell KB, Schnellrath LC, Medaglia ML, Hruby DE, Jordan R, Damaso CR. Increased susceptibility of Cantagalo virus to the antiviral effect of ST-246®. Antiviral Research. 97: 301-11. PMID 23257396 DOI: 10.1016/J.Antiviral.2012.11.010 |
0.709 |
|
| 2013 |
Leeds JM, Fenneteau F, Gosselin NH, Mouksassi MS, Kassir N, Marier JF, Chen Y, Grosenbach D, Frimm AE, Honeychurch KM, Chinsangaram J, Tyavanagimatt SR, Hruby DE, Jordan R. Pharmacokinetic and pharmacodynamic modeling to determine the dose of ST-246 to protect against smallpox in humans. Antimicrobial Agents and Chemotherapy. 57: 1136-43. PMID 23254433 DOI: 10.1128/Aac.00959-12 |
0.311 |
|
| 2013 |
Byrd CM, Dai D, Grosenbach DW, Berhanu A, Jones KF, Cardwell KB, Schneider C, Wineinger KA, Page JM, Harver C, Stavale E, Tyavanagimatt S, Stone MA, Bartenschlager R, Scaturro P, ... Hruby DE, et al. A novel inhibitor of dengue virus replication that targets the capsid protein. Antimicrobial Agents and Chemotherapy. 57: 15-25. PMID 23070172 DOI: 10.1128/Aac.01429-12 |
0.729 |
|
| 2013 |
Byrd CM, Bolken TC, Hruby DE. Vaccinia Virus Cysteine Proteinase Handbook of Proteolytic Enzymes. 2: 2390-2392. DOI: 10.1016/B978-0-12-382219-2.00533-0 |
0.712 |
|
| 2013 |
Byrd CM, Bolken TC, Hruby DE. Vaccinia Virus Metalloproteinase Handbook of Proteolytic Enzymes. 1: 1462-1464. DOI: 10.1016/B978-0-12-382219-2.00329-X |
0.703 |
|
| 2012 |
Byrd CM, Hruby DE. Screening for vaccinia virus egress inhibitors: separation of IMV, IEV, and EEV. Methods in Molecular Biology (Clifton, N.J.). 890: 113-21. PMID 22688763 DOI: 10.1007/978-1-61779-876-4_6 |
0.705 |
|
| 2012 |
Burgeson JR, Moore AL, Boutilier JK, Cerruti NR, Gharaibeh DN, Lovejoy CE, Amberg SM, Hruby DE, Tyavanagimatt SR, Allen RD, Dai D. SAR analysis of a series of acylthiourea derivatives possessing broad-spectrum antiviral activity Bioorganic and Medicinal Chemistry Letters. 22: 4263-4272. PMID 22664128 DOI: 10.1016/j.bmcl.2012.05.035 |
0.327 |
|
| 2012 |
Vliegen I, Yang G, Hruby D, Jordan R, Neyts J. Deletion of the vaccinia virus F13L gene results in a highly attenuated virus that mounts a protective immune response against subsequent vaccinia virus challenge. Antiviral Research. 93: 160-6. PMID 22138484 DOI: 10.1016/j.antiviral.2011.11.010 |
0.356 |
|
| 2010 |
Jordan R, Leeds JM, Tyavanagimatt S, Hruby DE. Development of ST-246® for Treatment of Poxvirus Infections. Viruses. 2: 2409-35. PMID 21994624 DOI: 10.3390/V2112409 |
0.412 |
|
| 2010 |
Byrd C, Harver C, Cardwell K, Grosenbach D, Berhanu A, Dai D, Hruby D, Jordan R. Small Molecule Inhibitors of Dengue Virus Replication are Active In Vivo Antiviral Research. 86: A30-A31. DOI: 10.1016/J.Antiviral.2010.02.364 |
0.693 |
|
| 2010 |
Byrd CM, Hruby DE. Need for dengue virus drug discovery Handbook of Disease Outbreaks: Prevention, Detection and Control. 343-349. |
0.713 |
|
| 2009 |
Berhanu A, King DS, Mosier S, Jordan R, Jones KF, Hruby DE, Grosenbach DW. ST-246 inhibits in vivo poxvirus dissemination, virus shedding, and systemic disease manifestation. Antimicrobial Agents and Chemotherapy. 53: 4999-5009. PMID 19752270 DOI: 10.1128/AAC.00678-09 |
0.363 |
|
| 2009 |
Chen Y, Honeychurch KM, Yang G, Byrd CM, Harver C, Hruby DE, Jordan R. Vaccinia virus p37 interacts with host proteins associated with LE-derived transport vesicle biogenesis. Virology Journal. 6: 44. PMID 19400954 DOI: 10.1186/1743-422X-6-44 |
0.709 |
|
| 2009 |
Huggins J, Goff A, Hensley L, Mucker E, Shamblin J, Wlazlowski C, Johnson W, Chapman J, Larsen T, Twenhafel N, Karem K, Damon IK, Byrd CM, Bolken TC, Jordan R, ... Hruby D, et al. Nonhuman primates are protected from smallpox virus or monkeypox virus challenges by the antiviral drug ST-246. Antimicrobial Agents and Chemotherapy. 53: 2620-5. PMID 19349521 DOI: 10.1128/Aac.00021-09 |
0.699 |
|
| 2009 |
Jordan R, Goff A, Frimm A, Corrado ML, Hensley LE, Byrd CM, Mucker E, Shamblin J, Bolken TC, Wlazlowski C, Johnson W, Chapman J, Twenhafel N, Tyavanagimatt S, Amantana A, ... ... Hruby DE, et al. ST-246 antiviral efficacy in a nonhuman primate monkeypox model: determination of the minimal effective dose and human dose justification. Antimicrobial Agents and Chemotherapy. 53: 1817-22. PMID 19223621 DOI: 10.1128/Aac.01596-08 |
0.633 |
|
| 2009 |
Smith SK, Olson VA, Karem KL, Jordan R, Hruby DE, Damon IK. In vitro efficacy of ST246 against smallpox and monkeypox. Antimicrobial Agents and Chemotherapy. 53: 1007-12. PMID 19075062 DOI: 10.1128/AAC.01044-08 |
0.338 |
|
| 2009 |
Byrd C, Page J, Harver C, Grosenbach D, Berhanu A, Hruby D, Jordan R. Novel Small Molecule Inhibitors of Dengue Virus Replication Antiviral Research. 82: A38. DOI: 10.1016/J.Antiviral.2009.02.078 |
0.713 |
|
| 2008 |
Duraffour S, Vigne S, Vermeire K, Garcel A, Vanstreels E, Daelemans D, Yang G, Jordan R, Hruby DE, Crance JM, Garin D, Andrei G, Snoeck R. Specific targeting of the F13L protein by ST-246 affects orthopoxvirus production differently. Antiviral Therapy. 13: 977-90. PMID 19195323 |
0.322 |
|
| 2008 |
Larson RA, Dai D, Hosack VT, Tan Y, Bolken TC, Hruby DE, Amberg SM. Identification of a broad-spectrum arenavirus entry inhibitor. Journal of Virology. 82: 10768-75. PMID 18715909 DOI: 10.1128/JVI.00941-08 |
0.359 |
|
| 2008 |
Grosenbach DW, Jordan R, King DS, Berhanu A, Warren TK, Kirkwood-Watts DL, Tyavanagimatt S, Tan Y, Wilson RL, Jones KF, Hruby DE. Immune responses to the smallpox vaccine given in combination with ST-246, a small-molecule inhibitor of poxvirus dissemination. Vaccine. 26: 933-46. PMID 18226434 DOI: 10.1016/J.Vaccine.2007.11.095 |
0.58 |
|
| 2008 |
Berhanu A, Wilson RL, Kirkwood-Watts DL, King DS, Warren TK, Lund SA, Brown LL, Krupkin AK, Vandermay E, Weimers W, Honeychurch KM, Grosenbach DW, Jones KF, Hruby DE. Vaccination of BALB/c mice with Escherichia coli-expressed vaccinia virus proteins A27L, B5R, and D8L protects mice from lethal vaccinia virus challenge. Journal of Virology. 82: 3517-29. PMID 18199639 DOI: 10.1128/Jvi.01854-07 |
0.674 |
|
| 2008 |
Byrd CM, Page J, Hruby DE, Jordan R. Orthopoxvirus: Biology, pathology and therapy Drugs of the Future. 33: 875-890. DOI: 10.1358/dof.2008.33.10.1238226 |
0.655 |
|
| 2008 |
Chen Y, Harver C, Warren T, Hruby D, Jordan R. Establishment of a Cell-based HTS System for Discovery of Anti-Flavivirus Drugs Antiviral Research. 78: A36. DOI: 10.1016/J.Antiviral.2008.01.066 |
0.555 |
|
| 2007 |
Duraffour S, Snoeck R, de Vos R, van Den Oord JJ, Crance JM, Garin D, Hruby DE, Jordan R, De Clercq E, Andrei G. Activity of the anti-orthopoxvirus compound ST-246 against vaccinia, cowpox and camelpox viruses in cell monolayers and organotypic raft cultures. Antiviral Therapy. 12: 1205-16. PMID 18240860 |
0.323 |
|
| 2007 |
Katritch V, Byrd CM, Tseitin V, Dai D, Raush E, Totrov M, Abagyan R, Jordan R, Hruby DE. Discovery of small molecule inhibitors of ubiquitin-like poxvirus proteinase I7L using homology modeling and covalent docking approaches. Journal of Computer-Aided Molecular Design. 21: 549-58. PMID 17960327 DOI: 10.1007/S10822-007-9138-7 |
0.635 |
|
| 2007 |
Yang SJ, Hruby DE. Vaccinia virus A12L protein and its AG/A proteolysis play an important role in viral morphogenic transition. Virology Journal. 4: 73. PMID 17625005 DOI: 10.1186/1743-422X-4-73 |
0.447 |
|
| 2007 |
Warren TK, Lund SA, Jones KF, Hruby DE. Comparison of transformation protocols in Streptococcus gordonii and evaluation of native promoter strength using a multiple-copy plasmid. Canadian Journal of Microbiology. 53: 417-26. PMID 17538652 DOI: 10.1139/W07-004 |
0.616 |
|
| 2007 |
Honeychurch KM, Yang G, Jordan R, Hruby DE. The vaccinia virus F13L YPPL motif is required for efficient release of extracellular enveloped virus. Journal of Virology. 81: 7310-5. PMID 17475658 DOI: 10.1128/Jvi.00034-07 |
0.442 |
|
| 2007 |
Alzhanova D, Hruby DE. A host cell membrane protein, golgin-97, is essential for poxvirus morphogenesis. Virology. 362: 421-7. PMID 17276477 DOI: 10.1016/J.Virol.2007.01.003 |
0.463 |
|
| 2007 |
Alzhanova D, Hruby DE. Erratum: A trans-golgi network resident protein, golgin-97, accumulates in viral factories and incorporates into virions during poxvirus infection (Journal of Virology (2006)80, 23(11520-11527)) Journal of Virology. 81. DOI: 10.1128/Jvi.02573-06 |
0.388 |
|
| 2007 |
KEITH K, KERN E, SANDERS S, CONLEY R, JORDAN R, HRUBY D, PAINTER G, PRICHARD M. Combinations of CMX-001 and ST-246 Synergistically Inhibit Orthopoxvirus Replication In Vitro Antiviral Research. 74: A79-A80. DOI: 10.1016/J.Antiviral.2007.01.135 |
0.321 |
|
| 2007 |
BYRD C, STAVALE E, WIECZOREK A, TRAN T, HRUBY D, JORDAN R. Discovery of Novel Small Molecule Inhibitors of Dengue Virus Replication Antiviral Research. 74: A77-A77. DOI: 10.1016/J.Antiviral.2007.01.130 |
0.692 |
|
| 2006 |
Alzhanova D, Hruby DE. A trans-Golgi network resident protein, golgin-97, accumulates in viral factories and incorporates into virions during poxvirus infection. Journal of Virology. 80: 11520-7. PMID 16987983 DOI: 10.1128/Jvi.00287-06 |
0.5 |
|
| 2006 |
Moerdyk MJ, Byrd CM, Hruby DE. Analysis of vaccinia virus temperature-sensitive I7L mutants reveals two potential functional domains. Virology Journal. 3: 64. PMID 16945137 DOI: 10.1186/1743-422X-3-64 |
0.69 |
|
| 2006 |
Byrd CM, Hruby DE. Vaccinia virus proteolysis--a review. Reviews in Medical Virology. 16: 187-202. PMID 16710840 DOI: 10.1002/Rmv.499 |
0.735 |
|
| 2006 |
Yoder JD, Chen TS, Gagnier CR, Vemulapalli S, Maier CS, Hruby DE. Pox proteomics: mass spectrometry analysis and identification of Vaccinia virion proteins. Virology Journal. 3: 10. PMID 16509968 DOI: 10.1186/1743-422X-3-10 |
0.479 |
|
| 2006 |
Honeychurch KM, Byrd CM, Hruby DE. Mutational analysis of the potential catalytic residues of the VV G1L metalloproteinase. Virology Journal. 3: 7. PMID 16504157 DOI: 10.1186/1743-422X-3-7 |
0.7 |
|
| 2006 |
Wilson RL, Brown LL, Kirkwood-Watts D, Warren TK, Lund SA, King DS, Jones KF, Hruby DE. Listeria monocytogenes 10403S HtrA is necessary for resistance to cellular stress and virulence. Infection and Immunity. 74: 765-8. PMID 16369036 DOI: 10.1128/Iai.74.1.765-768.2006 |
0.567 |
|
| 2006 |
Bolken TC, Laquerre S, Zhang Y, Bailey TR, Pevear DC, Kickner SS, Sperzel LE, Jones KF, Warren TK, Amanda Lund S, Kirkwood-Watts DL, King DS, Shurtleff AC, Guttieri MC, Deng Y, ... ... Hruby DE, et al. Identification and characterization of potent small molecule inhibitor of hemorrhagic fever New World arenaviruses. Antiviral Research. 69: 86-97. PMID 16343651 DOI: 10.1016/J.Antiviral.2005.10.008 |
0.67 |
|
| 2006 |
Hruby DE, Byrd CM. Less is more: Poxvirus proteolysis Microbe. 1: 70-75. DOI: 10.1128/Microbe.1.70.1 |
0.727 |
|
| 2006 |
Byrd CM, Hruby DE. Viral proteinases: Targets of opportunity Drug Development Research. 67: 501-510. DOI: 10.1002/Ddr.20114 |
0.695 |
|
| 2005 |
Blouch RE, Byrd CM, Hruby DE. Importance of disulphide bonds for vaccinia virus L1R protein function. Virology Journal. 2: 91. PMID 16336686 DOI: 10.1186/1743-422X-2-91 |
0.739 |
|
| 2005 |
Yang G, Pevear DC, Davies MH, Collett MS, Bailey T, Rippen S, Barone L, Burns C, Rhodes G, Tohan S, Huggins JW, Baker RO, Buller RL, Touchette E, Waller K, ... ... Hruby D, et al. An orally bioavailable antipoxvirus compound (ST-246) inhibits extracellular virus formation and protects mice from lethal orthopoxvirus Challenge. Journal of Virology. 79: 13139-49. PMID 16189015 DOI: 10.1128/JVI.79.20.13139-13149.2005 |
0.367 |
|
| 2005 |
Byrd CM, Hruby DE. Development of an in vitro cleavage assay system to examine vaccinia virus I7L cysteine proteinase activity. Virology Journal. 2: 63. PMID 16105175 DOI: 10.1186/1743-422X-2-63 |
0.708 |
|
| 2005 |
Warren TK, Lund SA, Jones KF, Hruby DE. Development of PLEX, a plasmid-based expression system for production of heterologous gene products by the gram-positive bacteria Streptococcus gordonii. Protein Expression and Purification. 40: 319-26. PMID 15766873 DOI: 10.1016/J.Pep.2004.10.019 |
0.672 |
|
| 2005 |
Byrd CM, Hruby DE. A conditional-lethal vaccinia virus mutant demonstrates that the I7L gene product is required for virion morphogenesis. Virology Journal. 2: 4. PMID 15701171 DOI: 10.1186/1743-422X-2-4 |
0.709 |
|
| 2004 |
Byrd CM, Bolken TC, Mjalli AM, Arimilli MN, Andrews RC, Rothlein R, Andrea T, Rao M, Owens KL, Hruby DE. New class of orthopoxvirus antiviral drugs that block viral maturation. Journal of Virology. 78: 12147-56. PMID 15507601 DOI: 10.1128/Jvi.78.22.12147-12156.2004 |
0.715 |
|
| 2004 |
Hedengren-Olcott M, Byrd CM, Watson J, Hruby DE. The vaccinia virus G1L putative metalloproteinase is essential for viral replication in vivo. Journal of Virology. 78: 9947-53. PMID 15331728 DOI: 10.1128/Jvi.78.18.9947-9953.2004 |
0.744 |
|
| 2004 |
Hedengren-Olcott M, Hruby DE. Conditional expression of vaccinia virus genes in mammalian cell lines expressing the tetracycline repressor. Journal of Virological Methods. 120: 9-12. PMID 15234804 DOI: 10.1016/J.Jviromet.2004.03.016 |
0.47 |
|
| 2004 |
Alzhanov D, Barnes J, Hruby DE, Rockey DD. Chlamydial development is blocked in host cells transfected with Chlamydophila caviae incA. Bmc Microbiology. 4: 24. PMID 15230981 DOI: 10.1186/1471-2180-4-24 |
0.418 |
|
| 2004 |
Yoder JD, Chen T, Hruby DE. Sequence-independent acylation of the vaccinia virus A-type inclusion protein. Biochemistry. 43: 8297-302. PMID 15222742 DOI: 10.1021/Bi0360197 |
0.431 |
|
| 2004 |
Byrd CM, Hruby DE. Construction of recombinant vaccinia virus: cloning into the thymidine kinase locus. Methods in Molecular Biology (Clifton, N.J.). 269: 31-40. PMID 15114005 DOI: 10.1385/1-59259-789-0:031 |
0.712 |
|
| 2003 |
Byrd CM, Bolken TC, Hruby DE. Molecular dissection of the vaccinia virus I7L core protein proteinase. Journal of Virology. 77: 11279-83. PMID 14512576 DOI: 10.1128/Jvi.77.20.11279-11283.2003 |
0.727 |
|
| 2003 |
Chen TS, Yoder JD, Hruby DE. Preparation of a large hydrophobic protein for mass spectrometry analysis: vaccina virus ATI protein. Analytical Biochemistry. 315: 277-80. PMID 12689839 DOI: 10.1016/S0003-2697(03)00030-7 |
0.443 |
|
| 2002 |
Jones CH, Dexter P, Evans AK, Liu C, Hultgren SJ, Hruby DE. Escherichia coli DegP protease cleaves between paired hydrophobic residues in a natural substrate: the PapA pilin. Journal of Bacteriology. 184: 5762-71. PMID 12270835 DOI: 10.1128/Jb.184.20.5762-5771.2002 |
0.342 |
|
| 2002 |
Byrd CM, Bolken TC, Hruby DE. The vaccinia virus I7L gene product is the core protein proteinase. Journal of Virology. 76: 8973-6. PMID 12163618 DOI: 10.1128/Jvi.76.17.8973-8976.2002 |
0.724 |
|
| 2002 |
Hansen SG, Cope TA, Hruby DE. BiZyme: a novel fusion protein-mediating selection of vaccinia virus recombinants by fluorescence and antibiotic resistance. Biotechniques. 32: 1178, 1180, 1182-7. PMID 12019792 DOI: 10.2144/02325Dd08 |
0.521 |
|
| 2002 |
Byrd CM, Bolken TC, Jones KF, Warren TK, Vella AT, McDonald J, King D, Blackwood Z, Hruby DE. Biological consequences of antigen and cytokine co-expression by recombinant Streptococcus gordonii vaccine vectors. Vaccine. 20: 2197-205. PMID 12009273 DOI: 10.1016/S0264-410X(02)00144-5 |
0.778 |
|
| 2002 |
Bolken TC, Franke CA, Jones KF, Bell RH, Swanson RM, King DS, Fischetti VA, Hruby DE. Analysis of factors affecting surface expression and immunogenicity of recombinant proteins expressed by gram-positive commensal vectors. Infection and Immunity. 70: 2487-91. PMID 11953386 DOI: 10.1128/Iai.70.5.2487-2491.2002 |
0.379 |
|
| 2001 |
Myscofski DM, Dutton EK, Cantor E, Zhang A, Hruby DE. Cleavage and purification of intein fusion proteins using the Streptococcus gordonii spex system. Preparative Biochemistry & Biotechnology. 31: 275-90. PMID 11513092 DOI: 10.1081/Pb-100104909 |
0.78 |
|
| 2001 |
Jones CH, Bolken TC, Jones KF, Zeller GO, Hruby DE. Conserved DegP protease in gram-positive bacteria is essential for thermal and oxidative tolerance and full virulence in Streptococcus pyogenes. Infection and Immunity. 69: 5538-45. PMID 11500427 DOI: 10.1128/Iai.69.9.5538-5545.2001 |
0.315 |
|
| 2001 |
Bolken TC, Franke CA, Zeller GO, Hruby DE. Identification of an intragenic integration site for foreign gene expression in recombinant Streptococcus gordonii strains. Applied Microbiology and Biotechnology. 55: 192-7. PMID 11330713 DOI: 10.1007/S002530000519 |
0.332 |
|
| 2001 |
Sharma A, Honma K, Evans RT, Hruby DE, Genco RJ. Oral immunization with recombinant Streptococcus gordonii expressing Porphyromonas gingivalis FimA domains Infection and Immunity. 69: 2928-2934. PMID 11292708 DOI: 10.1128/Iai.69.5.2928-2934.2001 |
0.31 |
|
| 2001 |
Bolken TC, Franke CA, Jones KF, Zeller GO, Jones CH, Dutton EK, Hruby DE. Inactivation of the srtA gene in Streptococcus gordonii inhibits cell wall anchoring of surface proteins and decreases in vitro and in vivo adhesion. Infection and Immunity. 69: 75-80. PMID 11119491 DOI: 10.1128/Iai.69.1.75-80.2001 |
0.359 |
|
| 2000 |
Myscofski DM, Dutton EK, Bolken TC, Franke CA, Hruby DE. Expression and purification of histidine-tagged proteins from the gram-positive Streptococcus gordonii SPEX system. Protein Expression and Purification. 20: 112-23. PMID 11035959 DOI: 10.1006/Prep.2000.1275 |
0.782 |
|
| 2000 |
Grosenbach DW, Hansen SG, Hruby DE. Identification and analysis of vaccinia virus palmitylproteins Virology. 275: 193-206. PMID 11017799 DOI: 10.1006/Viro.2000.0522 |
0.482 |
|
| 2000 |
Dutton EK, Ottum SA, Bolken TC, Franke CA, Hruby DE. Expression of active monomeric and dimeric nuclease A from the gram-positive Streptococcus gordonii surface protein expression system Protein Expression and Purification. 19: 158-172. PMID 10833403 DOI: 10.1006/Prep.2000.1223 |
0.38 |
|
| 2000 |
Nevrivy DJ, Peterson VJ, Avram D, Ishmael JE, Hansen SG, Dowell P, Hruby DE, Dawson MI, Leid M. Interaction of GRASP, a protein encoded by a novel retinoic acid-induced gene, with members of the cytohesin family of guanine nucleotide exchange factors Journal of Biological Chemistry. 275: 16827-16836. PMID 10828067 DOI: 10.1074/Jbc.275.22.16827 |
0.352 |
|
| 1999 |
Martin KH, Franke CA, Hruby DE. Novel acylation of poxvirus A-type inclusion proteins Virus Research. 60: 147-157. PMID 10392723 DOI: 10.1016/S0168-1702(99)00013-1 |
0.449 |
|
| 1999 |
Sharma A, Honma K, Sojar HT, Hruby DE, Kuramitsu HK, Genco RJ. Expression of saliva-binding epitopes of the Porphyromonas gingivalis FimA protein on the surface of Streptococcus gordonii Biochemical and Biophysical Research Communications. 258: 222-226. PMID 10222264 DOI: 10.1006/Bbrc.1999.0616 |
0.363 |
|
| 1999 |
Hansen SG, Grosenbach DW, Hruby DE. Analysis of the site occupancy constraints of primary amino acid sequences in the motif directing palmitylation of the vaccinia virus 37-kDa envelope protein Virology. 254: 124-137. PMID 9927580 DOI: 10.1006/Viro.1998.9543 |
0.383 |
|
| 1998 |
Myscofski DM, Hruby DE. SPEX, a system for the expression of recombinant proteins from gram-positive bacterial vectors. Protein Expression and Purification. 14: 409-17. PMID 9882576 DOI: 10.1006/Prep.1998.0962 |
0.78 |
|
| 1998 |
Grosenbach DW, Hruby DE. Analysis of a vaccinia virus mutant expressing a nonpalmitylated form of p37, a mediator of virion envelopment Journal of Virology. 72: 5108-5120. PMID 9573282 DOI: 10.1128/Jvi.72.6.5108-5120.1998 |
0.474 |
|
| 1998 |
Grosenbach DW, Hruby DE. Biology of vaccinia virus acylproteins Frontiers in Bioscience : a Journal and Virtual Library. 3: d354-364. PMID 9506927 |
0.387 |
|
| 1997 |
Sharma A, Sojar HT, Hruby DE, Kuramitsu HK, Genco RJ. Secretion of Porphyromonas gingivalis fimbrillin polypeptides by recombinant Streptococcus gordonii Biochemical and Biophysical Research Communications. 238: 313-316. PMID 9299501 DOI: 10.1006/Bbrc.1997.7306 |
0.305 |
|
| 1997 |
Martin KH, Grosenbach DW, Franke CA, Hruby DE. Identification and analysis of three myristylated vaccinia virus late proteins Journal of Virology. 71: 5218-5226. PMID 9188589 DOI: 10.1128/Jvi.71.7.5218-5226.1997 |
0.429 |
|
| 1997 |
Rockey DD, Grosenbach D, Hruby DE, Peacock MG, Heinzen RA, Hackstadt T. Chlamydia psittaci IncA is phosphorylated by the host cell and is exposed on the cytoplasmic face of the developing inclusion Molecular Microbiology. 24: 217-228. PMID 9140978 DOI: 10.1046/J.1365-2958.1997.3371700.X |
0.346 |
|
| 1997 |
Lee P, Hruby DE. Detection of recombinant protein based on reporter enzyme activity: chloramphenicol acetyltransferase Methods in Molecular Biology (Clifton, N.J.). 63: 31-40. PMID 9113638 DOI: 10.1385/0-89603-481-X:31 |
0.332 |
|
| 1997 |
Grosenbach DW, Ulaeto DO, Hruby DE. Palmitylation of the vaccinia virus 37-kDa major envelope antigen: Identification of a conserved acceptor motif and biological relevance Journal of Biological Chemistry. 272: 1956-1964. PMID 8999886 DOI: 10.1074/Jbc.272.3.1956 |
0.441 |
|
| 1996 |
Sharma A, Nagata H, Hamada N, Sojar HT, Hruby DE, Kuramitsu HK, Genco RJ. Expression of functional Porphyromonas gingivalis fimbrillin polypeptide domains on the surface of Streptococcus gordonii Applied and Environmental Microbiology. 62: 3933-3938. PMID 8899979 DOI: 10.1128/Aem.62.11.3933-3938.1996 |
0.338 |
|
| 1996 |
Ulaeto D, Grosenbach D, Hruby DE. The vaccinia virus 4c and A-type inclusion proteins are specific markers for the intracellular mature virus particle Journal of Virology. 70: 3372-3377. PMID 8648667 DOI: 10.1128/Jvi.70.6.3372-3377.1996 |
0.478 |
|
| 1995 |
Lee P, Hruby DE. Analysis of the role of the amino-terminal peptide of vaccinia virus structural protein precursors during proteolytic processing Virology. 207: 229-233. PMID 7871730 DOI: 10.1006/Viro.1995.1069 |
0.324 |
|
| 1995 |
Ulaeto D, Grosenbach D, Hruby DE. Brefeldin A inhibits vaccinia virus envelopment but does not prevent normal processing and localization of the putative envelopment receptor P37 Journal of General Virology. 76: 103-111. PMID 7844519 DOI: 10.1099/0022-1317-76-1-103 |
0.454 |
|
| 1995 |
Grosenbach D, Hruby DE. [4] Construction and use of recombinant vaccinia virus vectors Methods in Molecular Genetics. 7: 45-64. DOI: 10.1016/S1067-2389(06)80036-1 |
0.335 |
|
| 1994 |
Vanslyke JK, Hruby DE. Immunolocalization of vaccinia virus structural proteins during virion formation Virology. 198: 624-635. PMID 8291244 DOI: 10.1006/Viro.1994.1074 |
0.463 |
|
| 1994 |
Ravanello MP, Hruby DE. Characterization of the vaccinia virus L1R myristylprotein as a component of the intracellular virion envelope Journal of General Virology. 75: 1479-1483. PMID 8207414 DOI: 10.1099/0022-1317-75-6-1479 |
0.453 |
|
| 1994 |
Whitehead SS, Hruby DE. Differential utilization of a conserved motif for the proteolytic maturation of vaccinia virus proteins Virology. 200: 154-161. PMID 8128619 DOI: 10.1006/Viro.1994.1174 |
0.426 |
|
| 1994 |
Ravanello MP, Hruby DE. Conditional lethal expression of the vaccinia virus L1R myristylated protein reveals a role in virion assembly Journal of Virology. 68: 6401-6410. PMID 8083978 |
0.438 |
|
| 1994 |
Whitehead SS, Hruby DE. A transcriptionally controlled trans-processing assay: Putative identification of a vaccinia virus-encoded proteinase which cleaves precursor protein P25K Journal of Virology. 68: 7603-7608. PMID 7933150 |
0.355 |
|
| 1994 |
Ulaeto D, Hruby DE. Uses of vaccinia virus in vaccine delivery Current Opinion in Biotechnology. 5: 501-504. PMID 7765463 DOI: 10.1016/0958-1669(94)90064-7 |
0.368 |
|
| 1993 |
Child SJ, Hruby DE. Further characterization of an adenosine-containing modification of vaccinia virus proteins Bba - General Subjects. 1157: 217-228. PMID 8507659 DOI: 10.1016/0304-4165(93)90069-K |
0.496 |
|
| 1993 |
Franke CA, Hruby DE. Expression and Single-Step Purification of Enzymatically Active Vaccinia Virus Thymidine Kinase Containing an Engineered Oligohistidine Domain by Immobilized Metal Affinity-Chromatography Protein Expression and Purification. 4: 101-109. PMID 8471843 DOI: 10.1006/Prep.1993.1015 |
0.44 |
|
| 1993 |
Ravanello MP, Franke CA, Hruby DE. An NH2-terminal peptide from the vaccinia virus L1R protein directs the myristylation and virion envelope localization of a heterologous fusion protein Journal of Biological Chemistry. 268: 7585-7593. PMID 8463289 |
0.382 |
|
| 1993 |
Hruby DE, Birx, Kobayashi, Cross. Vaccinia virus: A novel approach for molecular engineering of peptide vaccines Seminars in Hematology. 30: 35-44. PMID 8303309 |
0.339 |
|
| 1993 |
Hruby DE, Franke CA. Viral acylproteins: greasing the wheels of assembly Trends in Microbiology. 1: 20-25. PMID 8143111 DOI: 10.1016/0966-842X(93)90020-R |
0.456 |
|
| 1993 |
Vanslyke JK, Lee P, Wilson EM, Hruby DE. Isolation and analysis of vaccinia virus previrions Virus Genes. 7: 311-324. PMID 8122392 DOI: 10.1007/Bf01703388 |
0.406 |
|
| 1992 |
Child SJ, Hruby DE. Evidence for multiple species of vaccinia virus-encoded palmitylated proteins Virology. 191: 262-271. PMID 1413506 DOI: 10.1016/0042-6822(92)90188-U |
0.464 |
|
| 1992 |
Spriggs MK, Hruby DE, Maliszewski CR, Pickup DJ, Sims JE, Buller RML, VanSlyke J. Vaccinia and cowpox viruses encode a novel secreted interleukin-1-binding protein Cell. 71: 145-152. PMID 1339315 DOI: 10.1016/0092-8674(92)90273-F |
0.442 |
|
| 1991 |
Tamin A, Esposito J, Hruby D. A single nucleotide substitution in the 5'-untranslated region of the vaccinia N2L gene is responsible for both alpha-amanitin-resistant and temperature-sensitive phenotypes. Virology. 182: 393-6. PMID 2024475 DOI: 10.1016/0042-6822(91)90688-8 |
0.32 |
|
| 1991 |
Hruby DE, Schneewind O, Wilson EM, Fischetti VA. Assembly and analysis of a functional vaccinia virus "amplicon" containing the C-repeat region from the M protein of Streptococcus pyogenes Proceedings of the National Academy of Sciences of the United States of America. 88: 3190-3194. PMID 2014239 DOI: 10.1073/Pnas.88.8.3190 |
0.481 |
|
| 1991 |
VanSlyke JK, Franke CA, Hruby DE. Proteolytic maturation of vaccinia virus core proteins: Identification of a conserved motif at the N termini of the 4b and 25K virion proteins Journal of General Virology. 72: 411-416. PMID 1993877 DOI: 10.1099/0022-1317-72-2-411 |
0.436 |
|
| 1991 |
Vanslyke JK, Whitehead SS, Wilson EM, Hruby DE. The multistep proteolytic maturation pathway utilized by vaccinia virus P4a protein: A degenerate conserved cleavage motif within core proteins Virology. 183: 467-478. PMID 1853556 DOI: 10.1016/0042-6822(91)90976-I |
0.414 |
|
| 1991 |
Black ME, Hruby DE. Structure and function of vaccinia virus thymidine kinase: Biomedical relevance and implications for antiviral drug design Reviews in Medical Virology. 1: 235-245. DOI: 10.1002/Rmv.1980010407 |
0.361 |
|
| 1990 |
Miner JN, Tamin A, Hruby DE. Anchoring a vaccinia virus promoter in the nucleus prevents its trans-activation by viral infection Virus Genes. 3: 355-359. PMID 2349786 DOI: 10.1007/Bf00569041 |
0.449 |
|
| 1990 |
Franke CA, Wilson EM, Hruby DE. Use of a cell-free system to indentify the vaccinia virus L1R gene product as the major late myristylated virion protein M25 Journal of Virology. 64: 5988-5996. PMID 2243383 DOI: 10.1128/Jvi.64.12.5988-5996.1990 |
0.415 |
|
| 1990 |
VanSlyke JK, Hruby DE. Posttranslational modification of vaccinia virus proteins Current Topics in Microbiology and Immunology. 163: 185-206. PMID 2242680 |
0.417 |
|
| 1990 |
Child SJ, Palumbo GJ, Mark R, Buller L, Hruby DE. Insertional inactivation of the large subunit of ribonucleotide reductase encoded by vaccinia virus is associated with reduced virulence in vivo Virology. 174: 625-629. PMID 2154895 DOI: 10.1016/0042-6822(90)90119-C |
0.452 |
|
| 1990 |
Black ME, Hruby DE. Quaternary structure of vaccinia virus thymidine kinase Biochemical and Biophysical Research Communications. 169: 1080-1086. PMID 2114104 DOI: 10.1016/0006-291X(90)92005-K |
0.443 |
|
| 1990 |
Miner JN, Hruby DE. Vaccinia virus: a versatile tool for molecular biologists Trends in Biotechnology. 8: 20-25. PMID 1366568 DOI: 10.1016/0167-7799(90)90126-I |
0.481 |
|
| 1989 |
Wilson EM, Franke CA, Black ME, Hruby DE. Expression vector pT7: TKII for the synthesis of authentic biologically active RNA encoding vaccinia virus thymidine kinase Gene. 77: 69-78. PMID 2744489 DOI: 10.1016/0378-1119(89)90360-0 |
0.371 |
|
| 1989 |
Miner JN, Hruby DE. Rifampicin prevents virosome localization of L65, an essential vaccinia virus polypeptide Virology. 170: 227-237. PMID 2718382 DOI: 10.1016/0042-6822(89)90370-X |
0.402 |
|
| 1989 |
Tengelsen LA, Hruby DE. Nucleotide sequence and transcriptional studies of the vaccinia virus KpnI I DNA fragment Virus Genes. 3: 175-187. PMID 2617851 DOI: 10.1007/Bf00125129 |
0.373 |
|
| 1988 |
Tamin A, Villarreal EC, Weinrich SL, Hruby DE. Nucleotide sequence and molecular genetic analysis of the vaccinia virus HindIII N/M region encoding the genes responsible for resistance to α-Amanitin Virology. 165: 141-150. PMID 3388767 DOI: 10.1016/0042-6822(88)90667-8 |
0.366 |
|
| 1988 |
Miner JN, Weinrich SL, Hruby DE. Molecular dissection of cis-acting regulatory elements from 5'-proximal regions of a vaccinia virus late gene cluster Journal of Virology. 62: 297-304. PMID 3334746 DOI: 10.1128/Jvi.62.1.297-304.1988 |
0.301 |
|
| 1988 |
Thomas G, Thorne BA, Thomas L, Allen RG, Hruby DE, Fuller R, Thorner J. Yeast KEX2 endopeptidase correctly cleaves a neuroendocrine prohormone in mammalian cells. Science (New York, N.Y.). 241: 226-30. PMID 3291117 DOI: 10.1126/Science.3291117 |
0.346 |
|
| 1988 |
Tengelsen LA, Slabaugh MB, Bibler JK, Hruby DE. Nucleotide sequence and molecular genetic analysis of the large subunit of ribonucleotide reductase encoded by vaccinia virus Virology. 164: 121-131. PMID 3284177 DOI: 10.1016/0042-6822(88)90627-7 |
0.379 |
|
| 1988 |
Wilson EM, Edbauer C, Hruby DE. Characterization of a binding factor that interacts with the sequences upstream of the vaccinia virus thymidine kinase gene Virus Genes. 2: 31-48. PMID 3227643 DOI: 10.1007/Bf00569735 |
0.357 |
|
| 1988 |
Hruby DE. Present and future applications of vaccinia virus as a vector Veterinary Parasitology. 29: 281-292. PMID 3059670 DOI: 10.1016/0304-4017(88)90129-X |
0.402 |
|
| 1988 |
Hruby DE, Hodges WM, Wilson EM, Franke CA, Fischetti VA. Expression of streptococcal M protein in mammalian cells Proceedings of the National Academy of Sciences of the United States of America. 85: 5714-5717. PMID 3041416 DOI: 10.1073/Pnas.85.15.5714 |
0.435 |
|
| 1988 |
Child SJ, Franke CA, Hruby DE. Inhibition of vaccinia virus replication by nicotinamide: evidence for ADP-ribosylation of viral proteins Virus Research. 9: 119-132. PMID 2965468 DOI: 10.1016/0168-1702(88)90027-5 |
0.475 |
|
| 1988 |
Franke CA, Hruby DE. Use of the gene encoding neomycin phosphotransferase II to convect linked markers into the vaccinia virus genome Nucleic Acids Research. 16: 1634. PMID 2831509 DOI: 10.1093/Nar/16.4.1634 |
0.368 |
|
| 1987 |
Wilson EM, Hruby DE. A single-stranded insertion vector (SSIV) for introducing foreign genes into the vaccinia virus genome Nucleic Acids Research. 15: 4690. PMID 3588306 DOI: 10.1093/Nar/15.11.4690 |
0.397 |
|
| 1987 |
Franke CA, Hruby DE. Association of non-viral proteins with recombinant vaccinia virus virions Archives of Virology. 94: 347-351. PMID 3472503 DOI: 10.1007/Bf01310729 |
0.504 |
|
| 1987 |
Hodges WM, Hruby DE. Cell-free translation of a chimeric eucaryotic-procaryotic message yields functional chloramphenicol acetyltransferase Analytical Biochemistry. 160: 65-67. PMID 3471096 DOI: 10.1016/0003-2697(87)90614-2 |
0.405 |
|
| 1987 |
Hruby DE, Thomas G. Use of Vaccinia Virus to Express Biopharmaceutical Products Pharmaceutical Research: An Official Journal of the American Association of Pharmaceutical Scientists. 4: 92-97. PMID 3334412 DOI: 10.1023/A:1016454600151 |
0.438 |
|
| 1987 |
Franke CA, Hruby DE. Quantitative assay of recombinant vaccinia virus-encoded neomycin phosphotransferase in infected eukaryotic cell lysates Journal of Virological Methods. 16: 147-154. PMID 3038938 DOI: 10.1016/0166-0934(87)90039-5 |
0.426 |
|
| 1986 |
Dougherty WG, Franke CA, Hruby DE. Construction of a recombinant vaccinia virus which expresses immunoreactive plant virus proteins. Virology. 149: 107-13. PMID 18640593 DOI: 10.1016/0042-6822(86)90091-7 |
0.489 |
|
| 1986 |
Thomas G, Herbert E, Hruby DE. Expression and cell type--specific processing of human preproenkephalin with a vaccinia recombinant. Science (New York, N.Y.). 232: 1641-3. PMID 3754979 DOI: 10.1126/Science.3754979 |
0.394 |
|
| 1986 |
Wilson EM, Hodges WM, Hruby DE. Construction of recombinant vaccinia virus strains using single-stranded DNA insertion vectors Gene. 49: 207-213. PMID 3569915 DOI: 10.1016/0378-1119(86)90281-7 |
0.393 |
|
| 1986 |
Hruby DE, Thomas G, Herbert E, Franke CA. Use of vaccinia virus as a neuropeptide expression vector. Methods in Enzymology. 124: 295-309. PMID 3012250 DOI: 10.1016/0076-6879(86)24022-7 |
0.449 |
|
| 1986 |
Weinrich SL, Hruby DE. A tandemly - oriented late gene cluster within the vaccinia virus genome Nucleic Acids Research. 14: 3003-3016. PMID 3008103 DOI: 10.1093/Nar/14.7.3003 |
0.334 |
|
| 1985 |
Franke CA, Hruby DE. Expression of recombinant vaccinia virus-derived alphavirus proteins in mosquito cells Journal of General Virology. 66: 2761-2765. PMID 4067584 DOI: 10.1099/0022-1317-66-12-2761 |
0.523 |
|
| 1985 |
Rice CM, Franke CA, Strauss JH, Hruby DE. Expression of Sindbis virus structural proteins via recombinant vaccinia virus: synthesis, processing, and incorporation into mature Sindbis virions. Journal of Virology. 56: 227-39. PMID 4032536 DOI: 10.1128/Jvi.56.1.227-239.1985 |
0.528 |
|
| 1985 |
Franke CA, Roseman NA, Hruby DE. Expression and regulation of the vaccinia virus thymidine kinase gene in non-permissive cells Virus Research. 3: 13-17. PMID 4024727 DOI: 10.1016/0168-1702(85)90037-1 |
0.401 |
|
| 1985 |
Hruby DE. Inhibition of vaccinia virus thymidine kinase by the Distal products of its own metabolic pathway Virus Research. 2: 151-156. PMID 3993232 DOI: 10.1016/0168-1702(85)90245-X |
0.395 |
|
| 1985 |
Franke CA, Berry ES, Smith AW, Hruby DE. Immunisation of cattle with a recombinant togavirus-vaccinia virus strain. Research in Veterinary Science. 39: 113-5. PMID 3862196 |
0.328 |
|
| 1985 |
Franke CA, Rice CM, Strauss JH, Hruby DE. Neomycin resistance as a dominant selectable marker for selection and isolation of vaccina virus recombinants Molecular and Cellular Biology. 5: 1918-1924. PMID 3018537 DOI: 10.1128/mcb.5.8.1918-1924.1985 |
0.473 |
|
| 1985 |
Rice CM, Franke CA, Strauss JH, Hruby DE. Expression of Sindbis virus structural proteins via recombinant vaccinia virus: synthesis, processing, and incorporation into mature Sindbis virions. Journal of Virology. 56: 227-239. DOI: 10.1128/jvi.56.1.227-239.1985 |
0.417 |
|
| 1984 |
Villarreal EC, Roseman NA, Hruby DE. Isolation of vaccinia virus mutants capable of replicating independently of the host cell nucleus Journal of Virology. 51: 359-366. PMID 6748162 DOI: 10.1128/Jvi.51.2.359-366.1984 |
0.393 |
|
| 1984 |
Hruby DE, Guarino LA. Novel codon utilization within the vaccinia virus thymidine kinase gene Virus Research. 1: 315-320. PMID 6099662 DOI: 10.1016/0168-1702(84)90020-0 |
0.329 |
|
| 1980 |
Hruby DE, Lynn DL, Kates JR. Identification of a virus-specified protein in the nucleus of vaccinia virus-infected cells Journal of General Virology. 47: 293-299. PMID 7365469 DOI: 10.1099/0022-1317-47-2-293 |
0.464 |
|
| 1980 |
Hruby DE, Lynn DL, Condit RC, Kates JR. Cellular differences in the molecular mechanisms of vaccinia virus host range restriction Journal of General Virology. 47: 485-488. PMID 6767809 DOI: 10.1099/0022-1317-47-2-485 |
0.421 |
|
| 1979 |
Hruby DE, Lynn DL, Kates JR. Vaccinia virus replication requires active participation of the host cell transcriptional apparatus Proceedings of the National Academy of Sciences of the United States of America. 76: 1887-1890. PMID 221909 DOI: 10.1073/Pnas.76.4.1887 |
0.47 |
|
| 1979 |
Hruby DE, Guarino LA, Kates JR. Vaccinia Virus Replication I. Requirement for the Host-Cell Nucleus Journal of Virology. 29: 705-715. DOI: 10.1128/jvi.29.2.705-715.1979 |
0.3 |
|
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