Dennis E. Hruby - Publications

Affiliations: 
Oregon State University, Corvallis, OR 
Area:
Microbiology Biology

199 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2019 Grosenbach DW, Hruby DE. Preliminary Screening and In Vitro Confirmation of Orthopoxvirus Antivirals. Methods in Molecular Biology (Clifton, N.J.). 2023: 143-155. PMID 31240676 DOI: 10.1007/978-1-4939-9593-6_9  0.32
2018 Russo AT, Grosenbach DW, Brasel TL, Baker RO, Cawthon AG, Reynolds E, Bailey T, Kuehl PJ, Sugita V, Agans K, Hruby DE. Effects of Treatment Delay on Efficacy of Tecovirimat Following Lethal Aerosol Monkeypox Virus Challenge in Cynomolgus Macaques. The Journal of Infectious Diseases. PMID 29982575 DOI: 10.1093/infdis/jiy326  0.32
2018 Grosenbach DW, Honeychurch K, Rose EA, Chinsangaram J, Frimm A, Maiti B, Lovejoy C, Meara I, Long P, Hruby DE. Oral Tecovirimat for the Treatment of Smallpox. The New England Journal of Medicine. 379: 44-53. PMID 29972742 DOI: 10.1056/NEJMoa1705688  0.32
2015 Berhanu A, Prigge JT, Silvera PM, Honeychurch KM, Hruby DE, Grosenbach DW. Treatment with the smallpox antiviral tecovirimat (ST-246) alone or in combination with ACAM2000 vaccination is effective as a postsymptomatic therapy for monkeypox virus infection. Antimicrobial Agents and Chemotherapy. 59: 4296-300. PMID 25896687 DOI: 10.1128/AAC.00208-15  1
2015 Duraffour S, Lorenzo MM, Zöller G, Topalis D, Grosenbach D, Hruby DE, Andrei G, Blasco R, Meyer H, Snoeck R. ST-246 is a key antiviral to inhibit the viral F13L phospholipase, one of the essential proteins for orthopoxvirus wrapping. The Journal of Antimicrobial Chemotherapy. 70: 1367-80. PMID 25630650 DOI: 10.1093/jac/dku545  1
2014 Sandoz KM, Valiant WG, Eriksen SG, Hruby DE, Allen RD, Rockey DD. The broad-spectrum antiviral compound ST-669 restricts chlamydial inclusion development and bacterial growth and localizes to host cell lipid droplets within treated cells. Antimicrobial Agents and Chemotherapy. 58: 3860-6. PMID 24777097 DOI: 10.1128/AAC.02064-13  1
2013 Mucker EM, Goff AJ, Shamblin JD, Grosenbach DW, Damon IK, Mehal JM, Holman RC, Carroll D, Gallardo N, Olson VA, Clemmons CJ, Hudson P, Hruby DE. Efficacy of tecovirimat (ST-246) in nonhuman primates infected with variola virus (Smallpox). Antimicrobial Agents and Chemotherapy. 57: 6246-53. PMID 24100494 DOI: 10.1128/AAC.00977-13  1
2013 Burgeson JR, Gharaibeh DN, Moore AL, Larson RA, Amberg SM, Bolken TC, Hruby DE, Dai D. Lead optimization of an acylhydrazone scaffold possessing antiviral activity against Lassa virus Bioorganic and Medicinal Chemistry Letters. 23: 5840-5843. PMID 24064500 DOI: 10.1016/j.bmcl.2013.08.103  1
2013 Byrd CM, Grosenbach DW, Hruby DE. Antiviral options for biodefense. Current Opinion in Virology. 3: 537-41. PMID 23773331 DOI: 10.1016/j.coviro.2013.05.020  1
2013 Amantana A, Chen Y, Tyavanagimatt SR, Jones KF, Jordan R, Chinsangaram J, Bolken TC, Leeds JM, Hruby DE. Pharmacokinetics and interspecies allometric scaling of ST-246, an oral antiviral therapeutic for treatment of orthopoxvirus infection. Plos One. 8: e61514. PMID 23637845 DOI: 10.1371/journal.pone.0061514  1
2013 Byrd CM, Grosenbach DW, Berhanu A, Dai D, Jones KF, Cardwell KB, Schneider C, Yang G, Tyavanagimatt S, Harver C, Wineinger KA, Page J, Stavale E, Stone MA, Fuller KP, ... ... Hruby DE, et al. Novel benzoxazole inhibitor of dengue virus replication that targets the NS3 helicase. Antimicrobial Agents and Chemotherapy. 57: 1902-12. PMID 23403421 DOI: 10.1128/AAC.02251-12  1
2013 Burgeson JR, Moore AL, Gharaibeh DN, Larson RA, Cerruti NR, Amberg SM, Hruby DE, Dai D. Discovery and optimization of potent broad-spectrum arenavirus inhibitors derived from benzimidazole and related heterocycles Bioorganic and Medicinal Chemistry Letters. 23: 750-756. PMID 23265900 DOI: 10.1016/j.bmcl.2012.11.093  1
2013 Dai D, Burgeson JR, Gharaibeh DN, Moore AL, Larson RA, Cerruti NR, Amberg SM, Bolken TC, Hruby DE. Discovery and optimization of potent broad-spectrum arenavirus inhibitors derived from benzimidazole. Bioorganic & Medicinal Chemistry Letters. 23: 744-9. PMID 23265895 DOI: 10.1016/j.bmcl.2012.11.095  1
2013 Santos-Fernandes É, Beltrame CO, Byrd CM, Cardwell KB, Schnellrath LC, Medaglia ML, Hruby DE, Jordan R, Damaso CR. Increased susceptibility of Cantagalo virus to the antiviral effect of ST-246®. Antiviral Research. 97: 301-11. PMID 23257396 DOI: 10.1016/j.antiviral.2012.11.010  1
2013 Leeds JM, Fenneteau F, Gosselin NH, Mouksassi MS, Kassir N, Marier JF, Chen Y, Grosenbach D, Frimm AE, Honeychurch KM, Chinsangaram J, Tyavanagimatt SR, Hruby DE, Jordan R. Pharmacokinetic and pharmacodynamic modeling to determine the dose of ST-246 to protect against smallpox in humans. Antimicrobial Agents and Chemotherapy. 57: 1136-43. PMID 23254433 DOI: 10.1128/AAC.00959-12  1
2013 Byrd CM, Dai D, Grosenbach DW, Berhanu A, Jones KF, Cardwell KB, Schneider C, Wineinger KA, Page JM, Harver C, Stavale E, Tyavanagimatt S, Stone MA, Bartenschlager R, Scaturro P, ... Hruby DE, et al. A novel inhibitor of dengue virus replication that targets the capsid protein. Antimicrobial Agents and Chemotherapy. 57: 15-25. PMID 23070172 DOI: 10.1128/AAC.01429-12  1
2013 Byrd CM, Bolken TC, Hruby DE. Vaccinia Virus Cysteine Proteinase Handbook of Proteolytic Enzymes. 2: 2390-2392. DOI: 10.1016/B978-0-12-382219-2.00533-0  1
2013 Byrd CM, Bolken TC, Hruby DE. Vaccinia Virus Metalloproteinase Handbook of Proteolytic Enzymes. 1: 1462-1464. DOI: 10.1016/B978-0-12-382219-2.00329-X  1
2012 Lederman ER, Davidson W, Groff HL, Smith SK, Warkentien T, Li Y, Wilkins KA, Karem KL, Akondy RS, Ahmed R, Frace M, Shieh WJ, Zaki S, Hruby DE, Painter WP, et al. Progressive vaccinia: case description and laboratory-guided therapy with vaccinia immune globulin, ST-246, and CMX001. The Journal of Infectious Diseases. 206: 1372-85. PMID 22904336 DOI: 10.1093/infdis/jis510  1
2012 Chinsangaram J, Honeychurch KM, Tyavanagimatt SR, Leeds JM, Bolken TC, Jones KF, Jordan R, Marbury T, Ruckle J, Mee-Lee D, Ross E, Lichtenstein I, Pickens M, Corrado M, Clarke JM, ... ... Hruby DE, et al. Safety and pharmacokinetics of the anti-orthopoxvirus compound ST-246 following a single daily oral dose for 14 days in human volunteers. Antimicrobial Agents and Chemotherapy. 56: 4900-5. PMID 22777041 DOI: 10.1128/AAC.00904-12  1
2012 Byrd CM, Hruby DE. Screening for vaccinia virus egress inhibitors: separation of IMV, IEV, and EEV. Methods in Molecular Biology (Clifton, N.J.). 890: 113-21. PMID 22688763 DOI: 10.1007/978-1-61779-876-4_6  1
2012 Burgeson JR, Moore AL, Boutilier JK, Cerruti NR, Gharaibeh DN, Lovejoy CE, Amberg SM, Hruby DE, Tyavanagimatt SR, Allen RD, Dai D. SAR analysis of a series of acylthiourea derivatives possessing broad-spectrum antiviral activity Bioorganic and Medicinal Chemistry Letters. 22: 4263-4272. PMID 22664128 DOI: 10.1016/j.bmcl.2012.05.035  1
2012 Sandoz KM, Eriksen SG, Jeffrey BM, Suchland RJ, Putman TE, Hruby DE, Jordan R, Rockey DD. Resistance to a novel antichlamydial compound is mediated through mutations in Chlamydia trachomatis secY. Antimicrobial Agents and Chemotherapy. 56: 4296-302. PMID 22644029 DOI: 10.1128/AAC.00356-12  1
2012 Chinsangaram J, Honeychurch KM, Tyavanagimatt SR, Bolken TC, Jordan R, Jones KF, Marbury T, Lichtenstein I, Pickens M, Corrado M, Landis P, Clarke JM, Frimm AM, Hruby DE. Pharmacokinetic comparison of a single oral dose of polymorph form i versus form V capsules of the antiorthopoxvirus compound ST-246 in human volunteers. Antimicrobial Agents and Chemotherapy. 56: 3582-6. PMID 22526314 DOI: 10.1128/AAC.06090-11  1
2011 Chen Y, Amantana A, Tyavanagimatt SR, Zima D, Yan XS, Kasi G, Weeks M, Stone MA, Weimers WC, Samuel P, Tan Y, Jones KF, Lee DR, Kickner SS, Saville BM, ... ... Hruby DE, et al. Comparison of the safety and pharmacokinetics of ST-246® after i.v. infusion or oral administration in mice, rabbits and monkeys. Plos One. 6: e23237. PMID 21858040 DOI: 10.1371/journal.pone.0023237  1
2011 Grosenbach DW, Jordan R, Hruby DE. Development of the small-molecule antiviral ST-246 as a smallpox therapeutic. Future Virology. 6: 653-671. PMID 21837250 DOI: 10.2217/fvl.11.27  1
2011 Smith SK, Self J, Weiss S, Carroll D, Braden Z, Regnery RL, Davidson W, Jordan R, Hruby DE, Damon IK. Effective antiviral treatment of systemic orthopoxvirus disease: ST-246 treatment of prairie dogs infected with monkeypox virus. Journal of Virology. 85: 9176-87. PMID 21697474 DOI: 10.1128/JVI.02173-10  1
2011 Cashman KA, Smith MA, Twenhafel NA, Larson RA, Jones KF, Allen RD, Dai D, Chinsangaram J, Bolken TC, Hruby DE, Amberg SM, Hensley LE, Guttieri MC. Evaluation of Lassa antiviral compound ST-193 in a guinea pig model. Antiviral Research. 90: 70-9. PMID 21371508 DOI: 10.1016/j.antiviral.2011.02.012  1
2010 Jordan R, Leeds JM, Tyavanagimatt S, Hruby DE. Development of ST-246® for Treatment of Poxvirus Infections. Viruses. 2: 2409-35. PMID 21994624 DOI: 10.3390/v2112409  1
2010 Berhanu A, King DS, Mosier S, Jordan R, Jones KF, Hruby DE, Grosenbach DW. Impact of ST-246® on ACAM2000â„¢ smallpox vaccine reactogenicity, immunogenicity, and protective efficacy in immunodeficient mice. Vaccine. 29: 289-303. PMID 21036130 DOI: 10.1016/j.vaccine.2010.10.039  1
2010 Bolken TC, Hruby DE. Tecovirimat for smallpox infections Drugs of Today. 46: 109-117. PMID 20393639 DOI: 101358/dot.2010.46.2.1437244  1
2010 Jordan R, Chinsangaram J, Bolken TC, Tyavanagimatt SR, Tien D, Jones KF, Frimm A, Corrado ML, Pickens M, Landis P, Clarke J, Marbury TC, Hruby DE. Safety and pharmacokinetics of the antiorthopoxvirus compound ST-246 following repeat oral dosing in healthy adult subjects. Antimicrobial Agents and Chemotherapy. 54: 2560-6. PMID 20385870 DOI: 10.1128/AAC.01689-09  1
2010 Grosenbach DW, Berhanu A, King DS, Mosier S, Jones KF, Jordan RA, Bolken TC, Hruby DE. Efficacy of ST-246 versus lethal poxvirus challenge in immunodeficient mice. Proceedings of the National Academy of Sciences of the United States of America. 107: 838-43. PMID 20080762 DOI: 10.1073/pnas.0912134107  1
2010 Byrd CM, Hruby DE. Need for dengue virus drug discovery Handbook of Disease Outbreaks: Prevention, Detection and Control. 343-349.  1
2009 Berhanu A, King DS, Mosier S, Jordan R, Jones KF, Hruby DE, Grosenbach DW. ST-246 inhibits in vivo poxvirus dissemination, virus shedding, and systemic disease manifestation. Antimicrobial Agents and Chemotherapy. 53: 4999-5009. PMID 19752270 DOI: 10.1128/AAC.00678-09  1
2009 Chen Y, Honeychurch KM, Yang G, Byrd CM, Harver C, Hruby DE, Jordan R. Vaccinia virus p37 interacts with host proteins associated with LE-derived transport vesicle biogenesis. Virology Journal. 6: 44. PMID 19400954 DOI: 10.1186/1743-422X-6-44  1
2009 Jordan R, Goff A, Frimm A, Corrado ML, Hensley LE, Byrd CM, Mucker E, Shamblin J, Bolken TC, Wlazlowski C, Johnson W, Chapman J, Twenhafel N, Tyavanagimatt S, Amantana A, ... ... Hruby DE, et al. ST-246 antiviral efficacy in a nonhuman primate monkeypox model: determination of the minimal effective dose and human dose justification. Antimicrobial Agents and Chemotherapy. 53: 1817-22. PMID 19223621 DOI: 10.1128/AAC.01596-08  1
2009 Smith SK, Olson VA, Karem KL, Jordan R, Hruby DE, Damon IK. In vitro efficacy of ST246 against smallpox and monkeypox. Antimicrobial Agents and Chemotherapy. 53: 1007-12. PMID 19075062 DOI: 10.1128/AAC.01044-08  1
2008 Duraffour S, Vigne S, Vermeire K, Garcel A, Vanstreels E, Daelemans D, Yang G, Jordan R, Hruby DE, Crance JM, Garin D, Andrei G, Snoeck R. Specific targeting of the F13L protein by ST-246 affects orthopoxvirus production differently. Antiviral Therapy. 13: 977-90. PMID 19195323  1
2008 Larson RA, Dai D, Hosack VT, Tan Y, Bolken TC, Hruby DE, Amberg SM. Identification of a broad-spectrum arenavirus entry inhibitor. Journal of Virology. 82: 10768-75. PMID 18715909 DOI: 10.1128/JVI.00941-08  1
2008 Nalca A, Hatkin JM, Garza NL, Nichols DK, Norris SW, Hruby DE, Jordan R. Evaluation of orally delivered ST-246 as postexposure prophylactic and antiviral therapeutic in an aerosolized rabbitpox rabbit model. Antiviral Research. 79: 121-7. PMID 18479761 DOI: 10.1016/j.antiviral.2008.03.005  1
2008 Jordan R, Tien D, Bolken TC, Jones KF, Tyavanagimatt SR, Strasser J, Frimm A, Corrado ML, Strome PG, Hruby DE. Single-dose safety and pharmacokinetics of ST-246, a novel orthopoxvirus egress inhibitor. Antimicrobial Agents and Chemotherapy. 52: 1721-7. PMID 18316519 DOI: 10.1128/AAC.01303-07  1
2008 Grosenbach DW, Jordan R, King DS, Berhanu A, Warren TK, Kirkwood-Watts DL, Tyavanagimatt S, Tan Y, Wilson RL, Jones KF, Hruby DE. Immune responses to the smallpox vaccine given in combination with ST-246, a small-molecule inhibitor of poxvirus dissemination. Vaccine. 26: 933-46. PMID 18226434 DOI: 10.1016/j.vaccine.2007.11.095  1
2008 Berhanu A, Wilson RL, Kirkwood-Watts DL, King DS, Warren TK, Lund SA, Brown LL, Krupkin AK, Vandermay E, Weimers W, Honeychurch KM, Grosenbach DW, Jones KF, Hruby DE. Vaccination of BALB/c mice with Escherichia coli-expressed vaccinia virus proteins A27L, B5R, and D8L protects mice from lethal vaccinia virus challenge. Journal of Virology. 82: 3517-29. PMID 18199639 DOI: 10.1128/JVI.01854-07  1
2008 Bolken TC, Hruby DE. Discovery and development of antiviral drugs for biodefense: experience of a small biotechnology company. Antiviral Research. 77: 1-5. PMID 17765333 DOI: 10.1016/j.antiviral.2007.07.003  1
2008 Byrd CM, Page J, Hruby DE, Jordan R. Orthopoxvirus: Biology, pathology and therapy Drugs of the Future. 33: 875-890. DOI: 10.1358/dof.2008.33.10.1238226  1
2007 Duraffour S, Snoeck R, de Vos R, van Den Oord JJ, Crance JM, Garin D, Hruby DE, Jordan R, De Clercq E, Andrei G. Activity of the anti-orthopoxvirus compound ST-246 against vaccinia, cowpox and camelpox viruses in cell monolayers and organotypic raft cultures. Antiviral Therapy. 12: 1205-16. PMID 18240860  1
2007 Katritch V, Byrd CM, Tseitin V, Dai D, Raush E, Totrov M, Abagyan R, Jordan R, Hruby DE. Discovery of small molecule inhibitors of ubiquitin-like poxvirus proteinase I7L using homology modeling and covalent docking approaches. Journal of Computer-Aided Molecular Design. 21: 549-58. PMID 17960327 DOI: 10.1007/s10822-007-9138-7  1
2007 Quenelle DC, Prichard MN, Keith KA, Hruby DE, Jordan R, Painter GR, Robertson A, Kern ER. Synergistic efficacy of the combination of ST-246 with CMX001 against orthopoxviruses. Antimicrobial Agents and Chemotherapy. 51: 4118-24. PMID 17724153 DOI: 10.1128/AAC.00762-07  1
2007 Yang SJ, Hruby DE. Vaccinia virus A12L protein and its AG/A proteolysis play an important role in viral morphogenic transition. Virology Journal. 4: 73. PMID 17625005 DOI: 10.1186/1743-422X-4-73  1
2007 Warren TK, Lund SA, Jones KF, Hruby DE. Comparison of transformation protocols in Streptococcus gordonii and evaluation of native promoter strength using a multiple-copy plasmid. Canadian Journal of Microbiology. 53: 417-26. PMID 17538652 DOI: 10.1139/W07-004  1
2007 Honeychurch KM, Yang G, Jordan R, Hruby DE. The vaccinia virus F13L YPPL motif is required for efficient release of extracellular enveloped virus. Journal of Virology. 81: 7310-5. PMID 17475658 DOI: 10.1128/JVI.00034-07  1
2007 Sbrana E, Jordan R, Hruby DE, Mateo RI, Xiao SY, Siirin M, Newman PC, DA Rosa AP, Tesh RB. Efficacy of the antipoxvirus compound ST-246 for treatment of severe orthopoxvirus infection. The American Journal of Tropical Medicine and Hygiene. 76: 768-73. PMID 17426185  1
2007 Alzhanova D, Hruby DE. A host cell membrane protein, golgin-97, is essential for poxvirus morphogenesis. Virology. 362: 421-7. PMID 17276477 DOI: 10.1016/j.virol.2007.01.003  1
2007 Quenelle DC, Buller RM, Parker S, Keith KA, Hruby DE, Jordan R, Kern ER. Efficacy of delayed treatment with ST-246 given orally against systemic orthopoxvirus infections in mice. Antimicrobial Agents and Chemotherapy. 51: 689-95. PMID 17116683 DOI: 10.1128/AAC.00879-06  1
2006 Alzhanova D, Hruby DE. A trans-Golgi network resident protein, golgin-97, accumulates in viral factories and incorporates into virions during poxvirus infection. Journal of Virology. 80: 11520-7. PMID 16987983 DOI: 10.1128/JVI.00287-06  1
2006 Moerdyk MJ, Byrd CM, Hruby DE. Analysis of vaccinia virus temperature-sensitive I7L mutants reveals two potential functional domains. Virology Journal. 3: 64. PMID 16945137 DOI: 10.1186/1743-422X-3-64  1
2006 Byrd CM, Hruby DE. Vaccinia virus proteolysis--a review. Reviews in Medical Virology. 16: 187-202. PMID 16710840 DOI: 10.1002/rmv.499  1
2006 Yoder JD, Chen TS, Gagnier CR, Vemulapalli S, Maier CS, Hruby DE. Pox proteomics: mass spectrometry analysis and identification of Vaccinia virion proteins. Virology Journal. 3: 10. PMID 16509968 DOI: 10.1186/1743-422X-3-10  1
2006 Honeychurch KM, Byrd CM, Hruby DE. Mutational analysis of the potential catalytic residues of the VV G1L metalloproteinase. Virology Journal. 3: 7. PMID 16504157 DOI: 10.1186/1743-422X-3-7  1
2006 Wilson RL, Brown LL, Kirkwood-Watts D, Warren TK, Lund SA, King DS, Jones KF, Hruby DE. Listeria monocytogenes 10403S HtrA is necessary for resistance to cellular stress and virulence. Infection and Immunity. 74: 765-8. PMID 16369036 DOI: 10.1128/IAI.74.1.765-768.2006  1
2006 Bolken TC, Laquerre S, Zhang Y, Bailey TR, Pevear DC, Kickner SS, Sperzel LE, Jones KF, Warren TK, Amanda Lund S, Kirkwood-Watts DL, King DS, Shurtleff AC, Guttieri MC, Deng Y, ... ... Hruby DE, et al. Identification and characterization of potent small molecule inhibitor of hemorrhagic fever New World arenaviruses. Antiviral Research. 69: 86-97. PMID 16343651 DOI: 10.1016/j.antiviral.2005.10.008  1
2006 Byrd CM, Hruby DE. Viral proteinases: Targets of opportunity Drug Development Research. 67: 501-510. DOI: 10.1002/ddr.20114  1
2006 Hruby DE, Byrd CM. Less is more: Poxvirus proteolysis Microbe. 1: 70-75.  1
2005 Blouch RE, Byrd CM, Hruby DE. Importance of disulphide bonds for vaccinia virus L1R protein function. Virology Journal. 2: 91. PMID 16336686 DOI: 10.1186/1743-422X-2-91  1
2005 Byrd CM, Hruby DE. Development of an in vitro cleavage assay system to examine vaccinia virus I7L cysteine proteinase activity. Virology Journal. 2: 63. PMID 16105175 DOI: 10.1186/1743-422X-2-63  1
2005 Wilson RL, Hruby DE. Commensal bacteria as a novel delivery system for subunit vaccines directed against agents of bioterrorism. Advanced Drug Delivery Reviews. 57: 1392-402. PMID 15935879 DOI: 10.1016/j.addr.2005.01.015  1
2005 Kotloff KL, Wasserman SS, Jones KF, Livio S, Hruby DE, Franke CA, Fischetti VA. Clinical and microbiological responses of volunteers to combined intranasal and oral inoculation with a Streptococcus gordonii carrier strain intended for future use as a group A streptococcus vaccine. Infection and Immunity. 73: 2360-6. PMID 15784582 DOI: 10.1128/IAI.73.4.2360-2366.2005  1
2005 Warren TK, Lund SA, Jones KF, Hruby DE. Development of PLEX, a plasmid-based expression system for production of heterologous gene products by the gram-positive bacteria Streptococcus gordonii. Protein Expression and Purification. 40: 319-26. PMID 15766873 DOI: 10.1016/j.pep.2004.10.019  1
2005 Byrd CM, Hruby DE. A conditional-lethal vaccinia virus mutant demonstrates that the I7L gene product is required for virion morphogenesis. Virology Journal. 2: 4. PMID 15701171 DOI: 10.1186/1743-422X-2-4  1
2004 Byrd CM, Bolken TC, Mjalli AM, Arimilli MN, Andrews RC, Rothlein R, Andrea T, Rao M, Owens KL, Hruby DE. New class of orthopoxvirus antiviral drugs that block viral maturation. Journal of Virology. 78: 12147-56. PMID 15507601 DOI: 10.1128/JVI.78.22.12147-12156.2004  1
2004 Hedengren-Olcott M, Byrd CM, Watson J, Hruby DE. The vaccinia virus G1L putative metalloproteinase is essential for viral replication in vivo. Journal of Virology. 78: 9947-53. PMID 15331728 DOI: 10.1128/JVI.78.18.9947-9953.2004  1
2004 Chen TF, Yoder JD, Hruby DE. Mass spectrometry analysis of synthetically myristoylated peptides. European Journal of Mass Spectrometry (Chichester, England). 10: 501-8. PMID 15302975 DOI: 10.1255/ejms.652  1
2004 Hedengren-Olcott M, Hruby DE. Conditional expression of vaccinia virus genes in mammalian cell lines expressing the tetracycline repressor. Journal of Virological Methods. 120: 9-12. PMID 15234804 DOI: 10.1016/j.jviromet.2004.03.016  1
2004 Alzhanov D, Barnes J, Hruby DE, Rockey DD. Chlamydial development is blocked in host cells transfected with Chlamydophila caviae incA. Bmc Microbiology. 4: 24. PMID 15230981 DOI: 10.1186/1471-2180-4-24  1
2004 Yoder JD, Chen T, Hruby DE. Sequence-independent acylation of the vaccinia virus A-type inclusion protein. Biochemistry. 43: 8297-302. PMID 15222742 DOI: 10.1021/bi0360197  1
2004 Byrd CM, Hruby DE. Construction of recombinant vaccinia virus: cloning into the thymidine kinase locus. Methods in Molecular Biology (Clifton, N.J.). 269: 31-40. PMID 15114005 DOI: 10.1385/1-59259-789-0:031  1
2003 Byrd CM, Bolken TC, Hruby DE. Molecular dissection of the vaccinia virus I7L core protein proteinase. Journal of Virology. 77: 11279-83. PMID 14512576 DOI: 10.1128/JVI.77.20.11279-11283.2003  1
2003 Chen TS, Yoder JD, Hruby DE. Preparation of a large hydrophobic protein for mass spectrometry analysis: vaccina virus ATI protein. Analytical Biochemistry. 315: 277-80. PMID 12689839 DOI: 10.1016/S0003-2697(03)00030-7  1
2002 Jones CH, Dexter P, Evans AK, Liu C, Hultgren SJ, Hruby DE. Escherichia coli DegP protease cleaves between paired hydrophobic residues in a natural substrate: the PapA pilin. Journal of Bacteriology. 184: 5762-71. PMID 12270835 DOI: 10.1128/JB.184.20.5762-5771.2002  1
2002 Byrd CM, Bolken TC, Hruby DE. The vaccinia virus I7L gene product is the core protein proteinase. Journal of Virology. 76: 8973-6. PMID 12163618 DOI: 10.1128/JVI.76.17.8973-8976.2002  1
2002 Hansen SG, Cope TA, Hruby DE. BiZyme: a novel fusion protein-mediating selection of vaccinia virus recombinants by fluorescence and antibiotic resistance. Biotechniques. 32: 1178, 1180, 1182-7. PMID 12019792  1
2002 Byrd CM, Bolken TC, Jones KF, Warren TK, Vella AT, McDonald J, King D, Blackwood Z, Hruby DE. Biological consequences of antigen and cytokine co-expression by recombinant Streptococcus gordonii vaccine vectors. Vaccine. 20: 2197-205. PMID 12009273 DOI: 10.1016/S0264-410X(02)00144-5  1
2002 Bolken TC, Franke CA, Jones KF, Bell RH, Swanson RM, King DS, Fischetti VA, Hruby DE. Analysis of factors affecting surface expression and immunogenicity of recombinant proteins expressed by gram-positive commensal vectors. Infection and Immunity. 70: 2487-91. PMID 11953386 DOI: 10.1128/IAI.70.5.2487-2491.2002  1
2002 Chen TS, Yoder JD, Hruby DE. Internal myristylation vaccinia virus protein, ATI Proceedings 50th Asms Conference On Mass Spectrometry and Allied Topics. 309-310.  1
2001 Franke CA, Bolken TC, Hruby DE. Studies on the genomic organization of recombinant Streptococcus gordonii and the development of a novel intergenic integration site for foreign gene expression Journal of Molecular Microbiology and Biotechnology. 3: 545-555. PMID 11545273  1
2001 Myscofski DM, Dutton EK, Cantor E, Zhang A, Hruby DE. Cleavage and purification of intein fusion proteins using the Streptococcus gordonii spex system. Preparative Biochemistry & Biotechnology. 31: 275-90. PMID 11513092 DOI: 10.1081/PB-100104909  1
2001 Jones CH, Bolken TC, Jones KF, Zeller GO, Hruby DE. Conserved DegP protease in gram-positive bacteria is essential for thermal and oxidative tolerance and full virulence in Streptococcus pyogenes. Infection and Immunity. 69: 5538-45. PMID 11500427 DOI: 10.1128/IAI.69.9.5538-5545.2001  1
2001 Bolken TC, Franke CA, Zeller GO, Hruby DE. Identification of an intragenic integration site for foreign gene expression in recombinant Streptococcus gordonii strains. Applied Microbiology and Biotechnology. 55: 192-7. PMID 11330713 DOI: 10.1007/s002530000519  1
2001 Sharma A, Honma K, Evans RT, Hruby DE, Genco RJ. Oral immunization with recombinant Streptococcus gordonii expressing Porphyromonas gingivalis FimA domains Infection and Immunity. 69: 2928-2934. PMID 11292708 DOI: 10.1128/IAI.69.5.2928-2934.2001  1
2001 Bolken TC, Franke CA, Jones KF, Zeller GO, Jones CH, Dutton EK, Hruby DE. Inactivation of the srtA gene in Streptococcus gordonii inhibits cell wall anchoring of surface proteins and decreases in vitro and in vivo adhesion. Infection and Immunity. 69: 75-80. PMID 11119491 DOI: 10.1128/IAI.69.1.75-80.2001  1
2001 Geller BL, Wade N, Gilberts TD, Hruby DE, Johanson R, Topisirovic L. Surface Expression of the Conserved C Repeat Region of Streptococcal M6 Protein within the Pip Bacteriophage Receptor of Lactococcus lactis Applied and Environmental Microbiology. 67: 5370-5376. DOI: 10.1128/AEM.67.12.5370-5376.2001  1
2000 Myscofski DM, Dutton EK, Bolken TC, Franke CA, Hruby DE. Expression and purification of histidine-tagged proteins from the gram-positive Streptococcus gordonii SPEX system. Protein Expression and Purification. 20: 112-23. PMID 11035959 DOI: 10.1006/prep.2000.1275  1
2000 Grosenbach DW, Hansen SG, Hruby DE. Identification and analysis of vaccinia virus palmitylproteins Virology. 275: 193-206. PMID 11017799 DOI: 10.1006/viro.2000.0522  1
2000 Dutton EK, Ottum SA, Bolken TC, Franke CA, Hruby DE. Expression of active monomeric and dimeric nuclease A from the gram-positive Streptococcus gordonii surface protein expression system Protein Expression and Purification. 19: 158-172. PMID 10833403 DOI: 10.1006/prep.2000.1223  1
2000 Nevrivy DJ, Peterson VJ, Avram D, Ishmael JE, Hansen SG, Dowell P, Hruby DE, Dawson MI, Leid M. Interaction of GRASP, a protein encoded by a novel retinoic acid-induced gene, with members of the cytohesin family of guanine nucleotide exchange factors Journal of Biological Chemistry. 275: 16827-16836. PMID 10828067 DOI: 10.1074/jbc.275.22.16827  1
2000 Franke CA, Bolman TM, Ottum SA, Jones KF, Hruby DE. Streptococcus gordonii strains resistant to fluorodeoxyuridine contain mutations in the thymidine kinase gene and are deficient in thymidine kinase activity Antimicrobial Agents and Chemotherapy. 44: 787-789. PMID 10681361 DOI: 10.1128/AAC.44.3.787-789.2000  1
1999 Martin KH, Franke CA, Hruby DE. Novel acylation of poxvirus A-type inclusion proteins Virus Research. 60: 147-157. PMID 10392723 DOI: 10.1016/S0168-1702(99)00013-1  1
1999 Sharma A, Honma K, Sojar HT, Hruby DE, Kuramitsu HK, Genco RJ. Expression of saliva-binding epitopes of the Porphyromonas gingivalis FimA protein on the surface of Streptococcus gordonii Biochemical and Biophysical Research Communications. 258: 222-226. PMID 10222264 DOI: 10.1006/bbrc.1999.0616  1
1999 Hansen SG, Grosenbach DW, Hruby DE. Analysis of the site occupancy constraints of primary amino acid sequences in the motif directing palmitylation of the vaccinia virus 37-kDa envelope protein Virology. 254: 124-137. PMID 9927580 DOI: 10.1006/viro.1998.9543  1
1999 Jones CH, Hruby DE. New targets for antibiotic development: Biogenesis of surface adherence structures Drug Discovery Today. 4: 495-504. DOI: 10.1016/S1359-6446(98)01261-6  1
1998 Myscofski DM, Hruby DE. SPEX, a system for the expression of recombinant proteins from gram-positive bacterial vectors. Protein Expression and Purification. 14: 409-17. PMID 9882576 DOI: 10.1006/prep.1998.0962  1
1998 Grosenbach DW, Hruby DE. Analysis of a vaccinia virus mutant expressing a nonpalmitylated form of p37, a mediator of virion envelopment Journal of Virology. 72: 5108-5120. PMID 9573282  1
1998 Grosenbach DW, Hruby DE. Biology of vaccinia virus acylproteins Frontiers in Bioscience : a Journal and Virtual Library. 3: d354-364. PMID 9506927  1
1998 Hruby DE, Franke CA, Coyle TC, Bolman T, Myscofski D, Jones KF. Gram-positive commensal bacteria: Novel delivery systems Proceedings of the Controlled Release Society. 220-221.  1
1997 Sharma A, Sojar HT, Hruby DE, Kuramitsu HK, Genco RJ. Secretion of Porphyromonas gingivalis fimbrillin polypeptides by recombinant Streptococcus gordonii Biochemical and Biophysical Research Communications. 238: 313-316. PMID 9299501 DOI: 10.1006/bbrc.1997.7306  1
1997 Martin KH, Grosenbach DW, Franke CA, Hruby DE. Identification and analysis of three myristylated vaccinia virus late proteins Journal of Virology. 71: 5218-5226. PMID 9188589  1
1997 Coyle TC, Franke CA, Hruby DE. Development of a radioactive protein A-based assay for analysis of surface protein expression in gram-positive bacteria Applied and Environmental Microbiology. 63: 2477-2480. PMID 9172373  1
1997 Rockey DD, Grosenbach D, Hruby DE, Peacock MG, Heinzen RA, Hackstadt T. Chlamydia psittaci IncA is phosphorylated by the host cell and is exposed on the cytoplasmic face of the developing inclusion Molecular Microbiology. 24: 217-228. PMID 9140978  1
1997 Lee P, Hruby DE. Detection of recombinant protein based on reporter enzyme activity: chloramphenicol acetyltransferase Methods in Molecular Biology (Clifton, N.J.). 63: 31-40. PMID 9113638  1
1997 Grosenbach DW, Ulaeto DO, Hruby DE. Palmitylation of the vaccinia virus 37-kDa major envelope antigen: Identification of a conserved acceptor motif and biological relevance Journal of Biological Chemistry. 272: 1956-1964. PMID 8999886 DOI: 10.1074/jbc.272.3.1956  1
1996 Sharma A, Nagata H, Hamada N, Sojar HT, Hruby DE, Kuramitsu HK, Genco RJ. Expression of functional Porphyromonas gingivalis fimbrillin polypeptide domains on the surface of Streptococcus gordonii Applied and Environmental Microbiology. 62: 3933-3938. PMID 8899979  1
1996 Ulaeto D, Grosenbach D, Hruby DE. The vaccinia virus 4c and A-type inclusion proteins are specific markers for the intracellular mature virus particle Journal of Virology. 70: 3372-3377. PMID 8648667  1
1995 Whitehead SS, Bersani VA, Hruby DE. Physical and molecular genetic analysis of the multistep proteolytic maturation pathway utilized by vaccinia virus P4a protein Journal of General Virology. 76: 717-721. PMID 7897360  1
1995 Lee P, Hruby DE. Analysis of the role of the amino-terminal peptide of vaccinia virus structural protein precursors during proteolytic processing Virology. 207: 229-233. PMID 7871730 DOI: 10.1006/viro.1995.1069  1
1995 Ulaeto D, Grosenbach D, Hruby DE. Brefeldin A inhibits vaccinia virus envelopment but does not prevent normal processing and localization of the putative envelopment receptor P37 Journal of General Virology. 76: 103-111. PMID 7844519  1
1995 Grosenbach D, Hruby DE. [4] Construction and use of recombinant vaccinia virus vectors Methods in Molecular Genetics. 7: 45-64. DOI: 10.1016/S1067-2389(06)80036-1  1
1994 Vanslyke JK, Hruby DE. Immunolocalization of vaccinia virus structural proteins during virion formation Virology. 198: 624-635. PMID 8291244  1
1994 Ravanello MP, Hruby DE. Characterization of the vaccinia virus L1R myristylprotein as a component of the intracellular virion envelope Journal of General Virology. 75: 1479-1483. PMID 8207414  1
1994 Lee P, Hruby DE. Proteolytic cleavage of vaccinia virus virion proteins. Mutational analysis of the specificity determinants Journal of Biological Chemistry. 269: 8616-8622. PMID 8132587  1
1994 Whitehead SS, Hruby DE. Differential utilization of a conserved motif for the proteolytic maturation of vaccinia virus proteins Virology. 200: 154-161. PMID 8128619 DOI: 10.1006/viro.1994.1174  1
1994 Ravanello MP, Hruby DE. Conditional lethal expression of the vaccinia virus L1R myristylated protein reveals a role in virion assembly Journal of Virology. 68: 6401-6410. PMID 8083978  1
1994 Whitehead SS, Hruby DE. A transcriptionally controlled trans-processing assay: Putative identification of a vaccinia virus-encoded proteinase which cleaves precursor protein P25K Journal of Virology. 68: 7603-7608. PMID 7933150  1
1994 Ulaeto D, Hruby DE. Uses of vaccinia virus in vaccine delivery Current Opinion in Biotechnology. 5: 501-504. PMID 7765463 DOI: 10.1016/0958-1669(94)90064-7  1
1993 Child SJ, Hruby DE. Further characterization of an adenosine-containing modification of vaccinia virus proteins Bba - General Subjects. 1157: 217-228. PMID 8507659 DOI: 10.1016/0304-4165(93)90069-K  1
1993 Franke CA, Hruby DE. Expression and Single-Step Purification of Enzymatically Active Vaccinia Virus Thymidine Kinase Containing an Engineered Oligohistidine Domain by Immobilized Metal Affinity-Chromatography Protein Expression and Purification. 4: 101-109. PMID 8471843 DOI: 10.1006/prep.1993.1015  1
1993 Ravanello MP, Franke CA, Hruby DE. An NH2-terminal peptide from the vaccinia virus L1R protein directs the myristylation and virion envelope localization of a heterologous fusion protein Journal of Biological Chemistry. 268: 7585-7593. PMID 8463289  1
1993 Hruby DE, Birx, Kobayashi, Cross. Vaccinia virus: A novel approach for molecular engineering of peptide vaccines Seminars in Hematology. 30: 35-44. PMID 8303309  1
1993 Hruby DE, Franke CA. Viral acylproteins: greasing the wheels of assembly Trends in Microbiology. 1: 20-25. PMID 8143111 DOI: 10.1016/0966-842X(93)90020-R  1
1993 Vanslyke JK, Lee P, Wilson EM, Hruby DE. Isolation and analysis of vaccinia virus previrions Virus Genes. 7: 311-324. PMID 8122392 DOI: 10.1007/BF01703388  1
1993 Lee P, Hruby DE. trans Processing of vaccinia virus core proteins Journal of Virology. 67: 4252-4263. PMID 7685413  1
1992 Black ME, Hruby DE. A single amino acid substitution abolishes feedback inhibition of vaccinia virus thymidine kinase Journal of Biological Chemistry. 267: 9743-9748. PMID 1577811  1
1992 Black ME, Hruby DE. Site-directed mutagenesis of a conserved domain in vaccinia virus thymidine kinase: Evidence for a potential role in magnesium binding Journal of Biological Chemistry. 267: 6801-6806. PMID 1551887  1
1992 Hruby DE, Wilson EM. [32] Use of fluorescent chloramphenicol derivative as a substrate for chloramphenicol acetyltransferase assays Methods in Enzymology. 216: 369-376. PMID 1479909 DOI: 10.1016/0076-6879(92)16034-H  1
1992 Child SJ, Hruby DE. Evidence for multiple species of vaccinia virus-encoded palmitylated proteins Virology. 191: 262-271. PMID 1413506 DOI: 10.1016/0042-6822(92)90188-U  1
1992 Spriggs MK, Hruby DE, Maliszewski CR, Pickup DJ, Sims JE, Buller RML, VanSlyke J. Vaccinia and cowpox viruses encode a novel secreted interleukin-1-binding protein Cell. 71: 145-152. PMID 1339315 DOI: 10.1016/0092-8674(92)90273-F  1
1991 Black ME, Hruby DE. Nucleotide sequence of the Escherichia coli thymidine kinase gene provides evidence for conservation of functional domains and quaternary structure Molecular Microbiology. 5: 373-379. PMID 2041474  1
1991 Hruby DE, Schneewind O, Wilson EM, Fischetti VA. Assembly and analysis of a functional vaccinia virus "amplicon" containing the C-repeat region from the M protein of Streptococcus pyogenes Proceedings of the National Academy of Sciences of the United States of America. 88: 3190-3194. PMID 2014239  1
1991 VanSlyke JK, Franke CA, Hruby DE. Proteolytic maturation of vaccinia virus core proteins: Identification of a conserved motif at the N termini of the 4b and 25K virion proteins Journal of General Virology. 72: 411-416. PMID 1993877  1
1991 Vanslyke JK, Whitehead SS, Wilson EM, Hruby DE. The multistep proteolytic maturation pathway utilized by vaccinia virus P4a protein: A degenerate conserved cleavage motif within core proteins Virology. 183: 467-478. PMID 1853556 DOI: 10.1016/0042-6822(91)90976-I  1
1991 Fischetti VA, Bessen DE, Schneewind O, Hruby DE. Protection against streptococcal pharyngeal colonization with vaccines composed of M protein conserved regions Advances in Experimental Medicine and Biology. 303: 159-167. PMID 1805563  1
1991 Black ME, Hruby DE. Structure and function of vaccinia virus thymidine kinase: Biomedical relevance and implications for antiviral drug design Reviews in Medical Virology. 1: 235-245.  1
1990 Miner JN, Tamin A, Hruby DE. Anchoring a vaccinia virus promoter in the nucleus prevents its trans-activation by viral infection Virus Genes. 3: 355-359. PMID 2349786 DOI: 10.1007/BF00569041  1
1990 Hruby DE, Brinkley JM, Kang HC, Haugland RP, Young SL, Melner MH. Use of a fluorescent chloramphenicol derivative as a substrate for CAT assays. Biotechniques. 8: 170-1. PMID 2317370  1
1990 Franke CA, Wilson EM, Hruby DE. Use of a cell-free system to indentify the vaccinia virus L1R gene product as the major late myristylated virion protein M25 Journal of Virology. 64: 5988-5996. PMID 2243383  1
1990 VanSlyke JK, Hruby DE. Posttranslational modification of vaccinia virus proteins Current Topics in Microbiology and Immunology. 163: 185-206. PMID 2242680  1
1990 Black ME, Hruby DE. Identification of the ATP-binding domain of vaccinia virus thymidine kinase Journal of Biological Chemistry. 265: 17584-17592. PMID 2211649  1
1990 Hruby DE. Vaccinia virus vectors: New strategies for producing recombinant vaccines Clinical Microbiology Reviews. 3: 153-170. PMID 2187593  1
1990 Child SJ, Palumbo GJ, Mark R, Buller L, Hruby DE. Insertional inactivation of the large subunit of ribonucleotide reductase encoded by vaccinia virus is associated with reduced virulence in vivo Virology. 174: 625-629. PMID 2154895 DOI: 10.1016/0042-6822(90)90119-C  1
1990 Black ME, Hruby DE. Quaternary structure of vaccinia virus thymidine kinase Biochemical and Biophysical Research Communications. 169: 1080-1086. PMID 2114104 DOI: 10.1016/0006-291X(90)92005-K  1
1990 Miner JN, Hruby DE. Vaccinia virus: a versatile tool for molecular biologists Trends in Biotechnology. 8: 20-25. PMID 1366568 DOI: 10.1016/0167-7799(90)90126-I  1
1989 Franke CA, Reynolds PL, Hruby DE. Fatty acid acylation of vaccinia virus proteins. Journal of Virology. 63: 4285-91. PMID 2778876  1
1989 Wilson EM, Franke CA, Black ME, Hruby DE. Expression vector pT7: TKII for the synthesis of authentic biologically active RNA encoding vaccinia virus thymidine kinase Gene. 77: 69-78. PMID 2744489 DOI: 10.1016/0378-1119(89)90360-0  1
1989 Miner JN, Hruby DE. Rifampicin prevents virosome localization of L65, an essential vaccinia virus polypeptide Virology. 170: 227-237. PMID 2718382 DOI: 10.1016/0042-6822(89)90370-X  1
1989 Fischetti VA, Hodges WM, Hruby DE. Protection against streptococcal pharyngeal colonization with a vaccinia: M protein recombinant Science. 244: 1487-1490. PMID 2660266  1
1989 Black ME, Wilson EM, Hruby DE. A simple sequencing gel-saving tip Biotechniques. 7: 1083. PMID 2629840  1
1989 Tengelsen LA, Hruby DE. Nucleotide sequence and transcriptional studies of the vaccinia virus KpnI I DNA fragment Virus Genes. 3: 175-187. PMID 2617851 DOI: 10.1007/BF00125129  1
1989 Miner JN, Hruby DE. DNA sequences that regulate expression of a vaccinia virus late gene (L65) and interact with a DNA-binding protein from infected cells Journal of Virology. 63: 2726-2736. PMID 2542585  1
1988 Edwards RH, Selby MJ, Mobley WC, Weinrich SL, Hruby DE, Rutter WJ. Processing and secretion of nerve growth factor: expression in mammalian cells with a vaccinia virus vector. Molecular and Cellular Biology. 8: 2456-64. PMID 3405211  1
1988 Tamin A, Villarreal EC, Weinrich SL, Hruby DE. Nucleotide sequence and molecular genetic analysis of the vaccinia virus HindIII N/M region encoding the genes responsible for resistance to α-Amanitin Virology. 165: 141-150. PMID 3388767 DOI: 10.1016/0042-6822(88)90667-8  1
1988 Miner JN, Weinrich SL, Hruby DE. Molecular dissection of cis-acting regulatory elements from 5'-proximal regions of a vaccinia virus late gene cluster Journal of Virology. 62: 297-304. PMID 3334746  1
1988 Thomas G, Thorne BA, Thomas L, Allen RG, Hruby DE, Fuller R, Thorner J. Yeast KEX2 endopeptidase correctly cleaves a neuroendocrine prohormone in mammalian cells. Science (New York, N.Y.). 241: 226-30. PMID 3291117  1
1988 Thomas G, Thorne BA, Hruby DE. Gene transfer techniques to study neuropeptide processing Annual Review of Physiology. 50: 323-332. PMID 3288095  1
1988 Tengelsen LA, Slabaugh MB, Bibler JK, Hruby DE. Nucleotide sequence and molecular genetic analysis of the large subunit of ribonucleotide reductase encoded by vaccinia virus Virology. 164: 121-131. PMID 3284177 DOI: 10.1016/0042-6822(88)90627-7  1
1988 Wilson EM, Edbauer C, Hruby DE. Characterization of a binding factor that interacts with the sequences upstream of the vaccinia virus thymidine kinase gene Virus Genes. 2: 31-48. PMID 3227643 DOI: 10.1007/BF00569735  1
1988 Hruby DE. Present and future applications of vaccinia virus as a vector Veterinary Parasitology. 29: 281-292. PMID 3059670 DOI: 10.1016/0304-4017(88)90129-X  1
1988 Hruby DE, Hodges WM, Wilson EM, Franke CA, Fischetti VA. Expression of streptococcal M protein in mammalian cells Proceedings of the National Academy of Sciences of the United States of America. 85: 5714-5717. PMID 3041416  1
1988 Child SJ, Franke CA, Hruby DE. Inhibition of vaccinia virus replication by nicotinamide: evidence for ADP-ribosylation of viral proteins Virus Research. 9: 119-132. PMID 2965468 DOI: 10.1016/0168-1702(88)90027-5  1
1988 Franke CA, Hruby DE. Use of the gene encoding neomycin phosphotransferase II to convect linked markers into the vaccinia virus genome Nucleic Acids Research. 16: 1634. PMID 2831509 DOI: 10.1093/nar/16.4.1634  1
1987 Weinrich SL, Hruby DE. Noncoordinate regulation of a vaccinia virus late gene cluster Journal of Virology. 61: 639-645. PMID 3806794  1
1987 Wilson EM, Hruby DE. A single-stranded insertion vector (SSIV) for introducing foreign genes into the vaccinia virus genome Nucleic Acids Research. 15: 4690. PMID 3588306 DOI: 10.1093/nar/15.11.4690  1
1987 Franke CA, Hruby DE. Association of non-viral proteins with recombinant vaccinia virus virions Archives of Virology. 94: 347-351. PMID 3472503 DOI: 10.1007/BF01310729  1
1987 Hodges WM, Hruby DE. Cell-free translation of a chimeric eucaryotic-procaryotic message yields functional chloramphenicol acetyltransferase Analytical Biochemistry. 160: 65-67. PMID 3471096 DOI: 10.1016/0003-2697(87)90614-2  1
1987 Hruby DE, Thomas G. Use of Vaccinia Virus to Express Biopharmaceutical Products Pharmaceutical Research: An Official Journal of the American Association of Pharmaceutical Scientists. 4: 92-97. PMID 3334412 DOI: 10.1023/A:1016454600151  1
1987 Franke CA, Hruby DE. Quantitative assay of recombinant vaccinia virus-encoded neomycin phosphotransferase in infected eukaryotic cell lysates Journal of Virological Methods. 16: 147-154. PMID 3038938 DOI: 10.1016/0166-0934(87)90039-5  1
1987 Roseman NA, Hruby DE. Nucleotide sequence and transcript organization of a region of the vaccinia virus genome which encodes a constitutively expressed gene required for DNA replication Journal of Virology. 61: 1398-1406. PMID 3033268  1
1986 Dougherty WG, Franke CA, Hruby DE. Construction of a recombinant vaccinia virus which expresses immunoreactive plant virus proteins. Virology. 149: 107-13. PMID 18640593 DOI: 10.1016/0042-6822(86)90091-7  1
1986 Thomas G, Herbert E, Hruby DE. Expression and cell type--specific processing of human preproenkephalin with a vaccinia recombinant. Science (New York, N.Y.). 232: 1641-3. PMID 3754979  1
1986 Wilson EM, Hodges WM, Hruby DE. Construction of recombinant vaccinia virus strains using single-stranded DNA insertion vectors Gene. 49: 207-213. PMID 3569915 DOI: 10.1016/0378-1119(86)90281-7  1
1986 Villarreal EC, Hruby DE. Mapping the genomic location of the gene encoding α-amanitin resistance in vaccinia virus mutants Journal of Virology. 57: 65-70. PMID 3455730  1
1986 Hruby DE, Thomas G, Herbert E, Franke CA. Use of vaccinia virus as a neuropeptide expression vector. Methods in Enzymology. 124: 295-309. PMID 3012250  1
1986 Weinrich SL, Hruby DE. A tandemly - oriented late gene cluster within the vaccinia virus genome Nucleic Acids Research. 14: 3003-3016. PMID 3008103 DOI: 10.1093/nar/14.7.3003  1
1985 Franke CA, Hruby DE. Expression of recombinant vaccinia virus-derived alphavirus proteins in mosquito cells Journal of General Virology. 66: 2761-2765. PMID 4067584  1
1985 Franke CA, Roseman NA, Hruby DE. Expression and regulation of the vaccinia virus thymidine kinase gene in non-permissive cells Virus Research. 3: 13-17. PMID 4024727 DOI: 10.1016/0168-1702(85)90037-1  1
1985 Hruby DE. Inhibition of vaccinia virus thymidine kinase by the Distal products of its own metabolic pathway Virus Research. 2: 151-156. PMID 3993232 DOI: 10.1016/0168-1702(85)90245-X  1
1985 Franke CA, Berry ES, Smith AW, Hruby DE. Immunisation of cattle with a recombinant togavirus-vaccinia virus strain. Research in Veterinary Science. 39: 113-5. PMID 3862196  1
1985 Franke CA, Rice CM, Strauss JH, Hruby DE. Neomycin resistance as a dominant selectable marker for selection and isolation of vaccina virus recombinants Molecular and Cellular Biology. 5: 1918-1924. PMID 3018537  1
1985 Weinrich SL, Niles EG, Hruby DE. Transcriptional and translational analysis of the vaccinia virus late gene L65 Journal of Virology. 55: 450-457. PMID 2991568  1
1984 Villarreal EC, Roseman NA, Hruby DE. Isolation of vaccinia virus mutants capable of replicating independently of the host cell nucleus Journal of Virology. 51: 359-366. PMID 6748162  1
1984 Hruby DE, Guarino LA. Novel codon utilization within the vaccinia virus thymidine kinase gene Virus Research. 1: 315-320. PMID 6099662 DOI: 10.1016/0168-1702(84)90020-0  1
1983 Hruby DE, Maki RA, Miller DB, Ball LA. Fine structure analysis and nucleotide sequence of the vaccinia virus thymidine kinase gene Proceedings of the National Academy of Sciences of the United States of America. 80: 3411-3415.  1
1982 Hruby DE, Miller DB, Ball LA. Synthesis of vaccinia virus thymidine kinase in microinjected Xenopus oocytes Virology. 123: 470-473. PMID 6294986 DOI: 10.1016/0042-6822(82)90282-3  1
1982 Hruby DE, Ball LA. Mapping and identification of the vaccinia virus thymidine kinase gene Journal of Virology. 43: 403-409. PMID 6287024  1
1982 Hruby DE, Ball LA. Techniques for the cell-free translation of viral RNA Laboratory and Research Methods in Biology and Medicine. 5: 279-303. PMID 6281598  1
1981 Hruby DE, Ball LA. Control of expression of the vaccinia virus thymidine kinase gene Journal of Virology. 40: 456-464. PMID 7321094  1
1981 Hruby DE, Ball LA. Cell-free synthesis of enzymatically active vaccinia virus thymidine kinase Virology. 113: 594-601. PMID 7269256 DOI: 10.1016/0042-6822(81)90187-2  1
1981 Guarino LA, Hruby DE, Ball LA, Kaesberg P. Translation of black beetle virus RNA and heterologous viral RNAs in cell-free lysates derived from Drosophila melanogaster Journal of Virology. 37: 500-505. PMID 6783766  1
1980 Hruby DE, Lynn DL, Kates JR. Identification of a virus-specified protein in the nucleus of vaccinia virus-infected cells Journal of General Virology. 47: 293-299. PMID 7365469  1
1980 Hruby DE, Lynn DL, Condit RC, Kates JR. Cellular differences in the molecular mechanisms of vaccinia virus host range restriction Journal of General Virology. 47: 485-488. PMID 6767809  1
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