Robert E. Lewis - Publications

University of Nebraska Medical Center, Omaha, NE, United States 
Microbiology Biology

50 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2020 Neilsen BK, Kelly DL, Chakraborty B, Kim HS, White MA, Lewis RE, Fisher KW. High-throughput identification of protein functional similarities using a gene-expression-based siRNA screen. Scientific Data. 7: 27. PMID 31964871 DOI: 10.1038/s41597-020-0365-2  0.92
2019 McMillan EA, Kwon G, Clemenceau JR, Fisher KW, Vaden RM, Shaikh AF, Neilsen BK, Kelly D, Potts MB, Sung YJ, Mendiratta S, Hight SK, Lee Y, MacMillan JB, Lewis RE, et al. A Genome-wide Functional Signature Ontology Map and Applications to Natural Product Mechanism of Action Discovery. Cell Chemical Biology. PMID 31378711 DOI: 10.1016/j.chembiol.2019.07.008  0.92
2019 Neilsen BK, Frodyma DE, McCall JL, Fisher KW, Lewis RE. ERK-mediated TIMELESS expression suppresses G2/M arrest in colon cancer cells. Plos One. 14: e0209224. PMID 30629587 DOI: 10.1371/journal.pone.0209224  0.92
2018 Razidlo GL, Johnson HJ, Stoeger SM, Cowan KH, Bessho T, Lewis RE. Correction: KSR1 is required for cell cycle reinitiation following DNA damage. The Journal of Biological Chemistry. 293: 19136. PMID 30530853 DOI: 10.1074/jbc.AAC118.006696  0.72
2018 Jiang C, Bi C, Jiang X, Tian T, Huang X, Wang C, Fernandez MR, Iqbal J, Chan WC, McKeithan TW, Lewis RE, Fu K. The miR-17~92 cluster activates mTORC1 in mantle cell lymphoma by targeting multiple regulators in the STK11/AMPK/TSC/mTOR pathway. British Journal of Haematology. PMID 30198569 DOI: 10.1111/bjh.15591  0.72
2018 Neilsen BK, Chakraborty B, McCall JL, Frodyma DE, Sleightholm RL, Fisher KW, Lewis RE. WDR5 supports colon cancer cells by promoting methylation of H3K4 and suppressing DNA damage. Bmc Cancer. 18: 673. PMID 29925347 DOI: 10.1186/s12885-018-4580-6  0.92
2018 Das B, Neilsen BK, Fisher KW, Gehring D, Hu Y, Volle DJ, Kim HS, McCall JL, Kelly DL, MacMillan JB, White MA, Lewis RE. A Functional Signature Ontology (FUSION) screen detects an AMPK inhibitor with selective toxicity toward human colon tumor cells. Scientific Reports. 8: 3770. PMID 29491475 DOI: 10.1038/s41598-018-22090-6  0.92
2017 Frodyma D, Neilsen B, Costanzo-Garvey D, Fisher K, Lewis R. Coordinating ERK signaling via the molecular scaffold Kinase Suppressor of Ras. F1000research. 6: 1621. PMID 29026529 DOI: 10.12688/f1000research.11895.1  0.36
2017 Neilsen BK, Frodyma DE, Lewis RE, Fisher KW. KSR as a therapeutic target for Ras-dependent cancers. Expert Opinion On Therapeutic Targets. PMID 28333549 DOI: 10.1080/14728222.2017.1311325  0.92
2017 Guo L, Costanzo-Garvey DL, Smith DR, Neilsen BK, MacDonald RG, Lewis RE. Kinase Suppressor of Ras 2 (KSR2) expression in the brain regulates energy balance and glucose homeostasis. Molecular Metabolism. 6: 194-205. PMID 28180061 DOI: 10.1016/j.molmet.2016.12.004  0.92
2016 Guo L, Costanzo-Garvey DL, Smith DR, Zavorka ME, Venable-Kang M, MacDonald RG, Lewis RE. Cell non-autonomous regulation of hepatic IGF-1 and neonatal growth by Kinase Suppressor of Ras 2 (KSR2). Scientific Reports. 6: 32093. PMID 27561547 DOI: 10.1038/srep32093  0.76
2016 McCall JL, Gehring D, Clymer BK, Fisher KW, Das B, Kelly DL, Kim H, White MA, Lewis RE. KSR1 and EPHB4 regulate Myc and PGC1β to promote survival of human colon tumor cells. Molecular and Cellular Biology. PMID 27273865 DOI: 10.1128/MCB.00087-16  0.76
2015 Bohovych I, Fernandez MR, Rahn JJ, Stackley KD, Bestman JE, Anandhan A, Franco R, Claypool SM, Lewis RE, Chan SS, Khalimonchuk O. Metalloprotease OMA1 Fine-tunes Mitochondrial Bioenergetic Function and Respiratory Supercomplex Stability. Scientific Reports. 5: 13989. PMID 26365306 DOI: 10.1038/srep13989  0.76
2015 Fisher KW, Das B, Kim HS, Clymer BK, Gehring D, Smith D, Costanzo-Garvey D, Fernandez M, Brattain MG, Kelly D, MacMillan J, White MA, Lewis RE. AMPK promotes aberrant PGC1β expression to support human colon tumor cell survival. Molecular and Cellular Biology. PMID 26351140 DOI: 10.1128/MCB.00528-15  0.76
2014 Kortum RL, Fernandez MR, Costanzo-Garvey DL, Johnson HJ, Fisher KW, Volle DJ, Lewis RE. Caveolin-1 is required for kinase suppressor of Ras 1 (KSR1)-mediated extracellular signal-regulated kinase 1/2 activation, H-RasV12-induced senescence, and transformation. Molecular and Cellular Biology. 34: 3461-72. PMID 25002533 DOI: 10.1128/MCB.01633-13  0.76
2014 Henry MD, Costanzo-Garvey DL, Klutho PJ, Lewis RE. Obesity-dependent dysregulation of glucose homeostasis in kinase suppressor of ras 2-/- mice. Physiological Reports. 2. PMID 24997067 DOI: 10.14814/phy2.12053  0.76
2014 Guo L, Volle DJ, Lewis RE. Identification of a truncated kinase suppressor of Ras 2 mRNA in sperm. Febs Open Bio. 4: 420-5. PMID 24918056 DOI: 10.1016/j.fob.2014.04.004  0.76
2013 Potts MB, Kim HS, Fisher KW, Hu Y, Carrasco YP, Bulut GB, Ou YH, Herrera-Herrera ML, Cubillos F, Mendiratta S, Xiao G, Hofree M, Ideker T, Xie Y, Huang LJ, ... Lewis RE, et al. Using functional signature ontology (FUSION) to identify mechanisms of action for natural products. Science Signaling. 6: ra90. PMID 24129700 DOI: 10.1126/scisignal.2004657  0.76
2013 Peters SL, Hlady RA, Opavska J, Klinkebiel D, Novakova S, Smith LM, Lewis RE, Karpf AR, Simpson MA, Wu L, Opavsky R. Essential role for Dnmt1 in the prevention and maintenance of MYC-induced T-cell lymphomas. Molecular and Cellular Biology. 33: 4321-33. PMID 24001767 DOI: 10.1128/MCB.00776-13  0.76
2012 Fernandez MR, Henry MD, Lewis RE. Kinase suppressor of Ras 2 (KSR2) regulates tumor cell transformation via AMPK. Molecular and Cellular Biology. 32: 3718-31. PMID 22801368 DOI: 10.1128/MCB.06754-11  0.76
2011 Klutho PJ, Costanzo-Garvey DL, Lewis RE. Regulation of glucose homeostasis by KSR1 and MARK2. Plos One. 6: e29304. PMID 22206009 DOI: 10.1371/journal.pone.0029304  0.76
2011 Xiao L, Chen Y, Ji M, Volle DJ, Lewis RE, Tsai MY, Dong J. KIBRA protein phosphorylation is regulated by mitotic kinase aurora and protein phosphatase 1. The Journal of Biological Chemistry. 286: 36304-15. PMID 21878642 DOI: 10.1074/jbc.M111.246850  0.76
2011 Fisher KW, Das B, Kortum RL, Chaika OV, Lewis RE. Kinase suppressor of ras 1 (KSR1) regulates PGC1α and estrogen-related receptor α to promote oncogenic Ras-dependent anchorage-independent growth. Molecular and Cellular Biology. 31: 2453-61. PMID 21518958 DOI: 10.1128/MCB.05255-11  0.76
2011 Llobet D, Eritja N, Domingo M, Bergada L, Mirantes C, Santacana M, Pallares J, Macià A, Yeramian A, Encinas M, Moreno-Bueno G, Palacios J, Lewis RE, Matias-Guiu X, Dolcet X. KSR1 is overexpressed in endometrial carcinoma and regulates proliferation and TRAIL-induced apoptosis by modulating FLIP levels. The American Journal of Pathology. 178: 1529-43. PMID 21435442 DOI: 10.1016/j.ajpath.2010.12.041  0.76
2009 Costanzo-Garvey DL, Pfluger PT, Dougherty MK, Stock JL, Boehm M, Chaika O, Fernandez MR, Fisher K, Kortum RL, Hong EG, Jun JY, Ko HJ, Schreiner A, Volle DJ, Treece T, ... ... Lewis RE, et al. KSR2 is an essential regulator of AMP kinase, energy expenditure, and insulin sensitivity. Cell Metabolism. 10: 366-78. PMID 19883615 DOI: 10.1016/j.cmet.2009.09.010  0.76
2009 Razidlo GL, Johnson HJ, Stoeger SM, Cowan KH, Bessho T, Lewis RE. KSR1 is required for cell cycle reinitiation following DNA damage. The Journal of Biological Chemistry. 284: 6705-15. PMID 19147494 DOI: 10.1074/jbc.M806457200  0.76
2009 Giurisato E, Lin J, Harding A, Cerutti E, Cella M, Lewis RE, Colonna M, Shaw AS. The mitogen-activated protein kinase scaffold KSR1 is required for recruitment of extracellular signal-regulated kinase to the immunological synapse. Molecular and Cellular Biology. 29: 1554-64. PMID 19139278 DOI: 10.1128/MCB.01421-08  0.76
2008 Chen C, Lewis RE, White MA. IMP modulates KSR1-dependent multivalent complex formation to specify ERK1/2 pathway activation and response thresholds. The Journal of Biological Chemistry. 283: 12789-96. PMID 18332145 DOI: 10.1074/jbc.M709305200  0.48
2006 Fusello AM, Mandik-Nayak L, Shih F, Lewis RE, Allen PM, Shaw AS. The MAPK scaffold kinase suppressor of Ras is involved in ERK activation by stress and proinflammatory cytokines and induction of arthritis. Journal of Immunology (Baltimore, Md. : 1950). 177: 6152-8. PMID 17056543  0.76
2006 Kortum RL, Johnson HJ, Costanzo DL, Volle DJ, Razidlo GL, Fusello AM, Shaw AS, Lewis RE. The molecular scaffold kinase suppressor of Ras 1 is a modifier of RasV12-induced and replicative senescence. Molecular and Cellular Biology. 26: 2202-14. PMID 16507997 DOI: 10.1128/MCB.26.6.2202-2214.2006  0.76
2006 Robertson SE, Setty SR, Sitaram A, Marks MS, Lewis RE, Chou MM. Extracellular signal-regulated kinase regulates clathrin-independent endosomal trafficking. Molecular Biology of the Cell. 17: 645-57. PMID 16314390 DOI: 10.1091/mbc.E05-07-0662  0.76
2005 Kortum RL, Costanzo DL, Haferbier J, Schreiner SJ, Razidlo GL, Wu MH, Volle DJ, Mori T, Sakaue H, Chaika NV, Chaika OV, Lewis RE. The molecular scaffold kinase suppressor of Ras 1 (KSR1) regulates adipogenesis. Molecular and Cellular Biology. 25: 7592-604. PMID 16107706 DOI: 10.1128/MCB.25.17.7592-7604.2005  0.76
2005 Kim M, Yan Y, Kortum RL, Stoeger SM, Sgagias MK, Lee K, Lewis RE, Cowan KH. Expression of kinase suppressor of Ras1 enhances cisplatin-induced extracellular signal-regulated kinase activation and cisplatin sensitivity. Cancer Research. 65: 3986-92. PMID 15899786 DOI: 10.1158/0008-5472.CAN-03-2334  0.76
2004 Razidlo GL, Kortum RL, Haferbier JL, Lewis RE. Phosphorylation regulates KSR1 stability, ERK activation, and cell proliferation. The Journal of Biological Chemistry. 279: 47808-14. PMID 15371409 DOI: 10.1074/jbc.M406395200  0.76
2004 Kortum RL, Lewis RE. The molecular scaffold KSR1 regulates the proliferative and oncogenic potential of cells. Molecular and Cellular Biology. 24: 4407-16. PMID 15121859 DOI: 10.1128/MCB.24.10.4407-4416.2004  0.76
2004 Matheny SA, Chen C, Kortum RL, Razidlo GL, Lewis RE, White MA. Ras regulates assembly of mitogenic signalling complexes through the effector protein IMP. Nature. 427: 256-60. PMID 14724641 DOI: 10.1038/nature02237  0.76
2003 Petrovas C, Jeay S, Lewis RE, Sonenshein GE. B-Myb repressor function is regulated by cyclin A phosphorylation and sequences within the C-terminal domain. Oncogene. 22: 2011-20. PMID 12673206 DOI: 10.1038/sj.onc.1206231  0.76
2002 Nguyen A, Burack WR, Stock JL, Kortum R, Chaika OV, Afkarian M, Muller WJ, Murphy KM, Morrison DK, Lewis RE, McNeish J, Shaw AS. Kinase suppressor of Ras (KSR) is a scaffold which facilitates mitogen-activated protein kinase activation in vivo. Molecular and Cellular Biology. 22: 3035-45. PMID 11940661 DOI: 10.1128/MCB.22.9.3035-3045.2002  0.76
2002 Brennan JA, Volle DJ, Chaika OV, Lewis RE. Phosphorylation regulates the nucleocytoplasmic distribution of kinase suppressor of Ras. The Journal of Biological Chemistry. 277: 5369-77. PMID 11741955 DOI: 10.1074/jbc.M109875200  0.72
2002 Johnson LR, Johnson TK, Desler M, Luster TA, Nowling T, Lewis RE, Rizzino A. Effects of B-Myb on gene transcription: phosphorylation-dependent activity ans acetylation by p300. The Journal of Biological Chemistry. 277: 4088-97. PMID 11733503 DOI: 10.1074/jbc.M105112200  0.76
2001 Santilli G, Cervellera MN, Johnson TK, Lewis RE, Iacobelli S, Sala A. PARP co-activates B-MYB through enhanced phosphorylation at cyclin/cdk2 sites. Oncogene. 20: 8167-74. PMID 11781832 DOI: 10.1038/sj.onc.1204943  0.76
1999 Johnson TK, Schweppe RE, Septer J, Lewis RE. Phosphorylation of B-Myb regulates its transactivation potential and DNA binding Journal of Biological Chemistry. 274: 36741-36749. PMID 10593981 DOI: 10.1074/jbc.274.51.36741  0.76
1999 Boehm JE, Chaika OV, Lewis RE. Rac-dependent anti-apoptotic signaling by the insulin receptor cytoplasmic domain. The Journal of Biological Chemistry. 274: 28632-6. PMID 10497231 DOI: 10.1074/jbc.274.40.28632  0.76
1999 Volle DJ, Fulton JA, Chaika OV, McDermott K, Huang H, Steinke LA, Lewis RE. Phosphorylation of the kinase suppressor of ras by associated kinases. Biochemistry. 38: 5130-7. PMID 10213618 DOI: 10.1021/bi983050d  0.76
1998 Joneson T, Fulton JA, Volle DJ, Chaika OV, Bar-Sagi D, Lewis RE. Kinase suppressor of Ras inhibits the activation of extracellular ligand-regulated (ERK) mitogen-activated protein (MAP) kinase by growth factors, activated Ras, and Ras effectors. The Journal of Biological Chemistry. 273: 7743-8. PMID 9516483 DOI: 10.1074/jbc.273.13.7743  0.76
1998 Boehm JE, Chaika OV, Lewis RE. Anti-apoptotic signaling by a colony-stimulating factor-1 receptor/insulin receptor chimera with a juxtamembrane deletion. The Journal of Biological Chemistry. 273: 7169-76. PMID 9507032 DOI: 10.1074/jbc.273.12.7169  0.76
1990 Lewis RE, Cao L, Perregaux D, Czech MP. Threonine 1336 of the human insulin receptor is a major target for phosphorylation by protein kinase C. Biochemistry. 29: 1807-13. PMID 2110001 DOI: 10.1021/bi00459a020  0.64
1989 Czech MP, Lewis RE, Corvera S. Multifunctional glycoprotein receptors for insulin and the insulin-like growth factors. Ciba Foundation Symposium. 145: 27-41; discussion 42. PMID 2551607 DOI: 10.1002/9780470513828.ch3  0.88
1988 Lewis RE, Czech MP. Phospholipid environment alters hormone-sensitivity of the purified insulin receptor kinase. The Biochemical Journal. 248: 829-36. PMID 2829843 DOI: 10.1042/bj2480829  0.64
1986 Czech MP, Yu KT, Lewis RE, Davis RJ, Mottola C, MacDonald RG, Necessary PC, Corvera S. Insulin receptor kinase and its mode of signaling membrane components. Diabetes/Metabolism Reviews. 1: 33-58. PMID 3013541 DOI: 10.1002/dmr.5610010104  0.64
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