Kenneth W. Witwer, Ph.D. - Publications

Affiliations: 
2010 Johns Hopkins University, Baltimore, MD 
Area:
Molecular Biology, Virology Biology, Cell Biology

64/168 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2023 Huang Y, Abdelmagid Abdelgawad AG, Turchinovich A, Queen S, Abreu CM, Zhu X, Batish M, Zheng L, Witwer KW. RNA landscapes of brain tissue and brain tissue-derived extracellular vesicles in simian immunodeficiency virus (SIV) infection and SIV-related central nervous system pathology. Biorxiv : the Preprint Server For Biology. PMID 37034720 DOI: 10.1101/2023.04.01.535193  0.342
2020 Zhao Z, Muth DC, Mulka K, Liao Z, Powell BH, Hancock GV, Metcalf Pate KA, Witwer KW. miRNA profiling of primate cervicovaginal lavage and extracellular vesicles reveals miR-186-5p as a potential antiretroviral factor in macrophages. Febs Open Bio. 10: 2021-2039. PMID 33017084 DOI: 10.1002/2211-5463.12952  0.486
2020 Huang Y, Cheng L, Turchinovich A, Mahairaki V, Troncoso JC, Pletniková O, Haughey NJ, Vella LJ, Hill AF, Zheng L, Witwer KW. Influence of species and processing parameters on recovery and content of brain tissue-derived extracellular vesicles. Journal of Extracellular Vesicles. 9: 1785746. PMID 32944174 DOI: 10.1080/20013078.2020.1785746  0.305
2020 Ahn JY, Datta S, Bandeira E, Cano M, Mallick E, Rai U, Powell B, Tian J, Witwer KW, Handa JT, Paulaitis ME. Release of extracellular vesicle miR-494-3p by ARPE-19 cells with impaired mitochondria. Biochimica Et Biophysica Acta. General Subjects. 129598. PMID 32240720 DOI: 10.1016/J.Bbagen.2020.129598  0.313
2019 Pérez PS, Romaniuk MA, Duette GA, Zhao Z, Huang Y, Martin-Jaular L, Witwer KW, Théry C, Ostrowski M. Extracellular vesicles and chronic inflammation during HIV infection. Journal of Extracellular Vesicles. 8: 1687275. PMID 31998449 DOI: 10.1080/20013078.2019.1687275  0.374
2019 Gámbaro F, Li Calzi M, Fagúndez P, Costa B, Greif G, Mallick E, Lyons S, Ivanov P, Witwer K, Cayota A, Tosar JP. Stable tRNA halves can be sorted into extracellular vesicles and delivered to recipient cells in a concentration-dependent manner. Rna Biology. 1-15. PMID 31885318 DOI: 10.1080/15476286.2019.1708548  0.304
2019 Jeon OH, Wilson DR, Clement CC, Rathod S, Cherry C, Powell B, Lee Z, Khalil AM, Green JJ, Campisi J, Santambrogio L, Witwer KW, Elisseeff JH. Senescence cell-associated extracellular vesicles serve as osteoarthritis disease and therapeutic markers. Jci Insight. 4. PMID 30944259 DOI: 10.1172/Jci.Insight.125019  0.34
2018 Clayton A, Buschmann D, Byrd JB, Carter DRF, Cheng L, Compton C, Daaboul G, Devitt A, Falcon-Perez JM, Gardiner C, Gustafson D, Harrison P, Helmbrecht C, Hendrix A, Hill A, ... ... Witwer KW, et al. Summary of the ISEV workshop on extracellular vesicles as disease biomarkers, held in Birmingham, UK, during December 2017. Journal of Extracellular Vesicles. 7: 1473707. PMID 31162490 DOI: 10.1080/20013078.2018.1473707  0.322
2018 Théry C, Witwer KW, Aikawa E, Alcaraz MJ, Anderson JD, Andriantsitohaina R, Antoniou A, Arab T, Archer F, Atkin-Smith GK, Ayre DC, Bach JM, Bachurski D, Baharvand H, Balaj L, et al. Minimal information for studies of extracellular vesicles 2018 (MISEV2018): a position statement of the International Society for Extracellular Vesicles and update of the MISEV2014 guidelines. Journal of Extracellular Vesicles. 7: 1535750. PMID 30637094 DOI: 10.1080/20013078.2018.1535750  0.309
2018 Soekmadji C, Hill AF, Wauben MH, Buzás EI, Di Vizio D, Gardiner C, Lötvall J, Sahoo S, Witwer KW. Towards mechanisms and standardization in extracellular vesicle and extracellular RNA studies: results of a worldwide survey. Journal of Extracellular Vesicles. 7: 1535745. PMID 30370018 DOI: 10.1080/20013078.2018.1535745  0.323
2018 Duette G, Pereyra Gerber P, Rubione J, Perez PS, Landay AL, Crowe SM, Liao Z, Witwer KW, Holgado MP, Salido J, Geffner J, Sued O, Palmer CS, Ostrowski M. Induction of HIF-1α by HIV-1 Infection in CD4 T Cells Promotes Viral Replication and Drives Extracellular Vesicle-Mediated Inflammation. Mbio. 9. PMID 30206166 DOI: 10.1128/Mbio.00757-18  0.365
2018 Witwer KW. Alternative miRNAs? Human sequences misidentified as plant miRNAs in plant studies and in human plasma. F1000research. 7: 244. PMID 29744036 DOI: 10.12688/F1000Research.14060.1  0.379
2018 Muth DC, Powell BH, Zhao Z, Witwer KW. miRNAs in platelet-poor blood plasma and purified RNA are highly stable: a confirmatory study. Bmc Research Notes. 11: 273. PMID 29728133 DOI: 10.1186/S13104-018-3378-6  0.419
2018 Chaudhuri AD, Dastgheyb RM, Yoo SW, Trout A, Talbot CC, Hao H, Witwer KW, Haughey NJ. TNFα and IL-1β modify the miRNA cargo of astrocyte shed extracellular vesicles to regulate neurotrophic signaling in neurons. Cell Death & Disease. 9: 363. PMID 29507357 DOI: 10.1038/S41419-018-0369-4  0.328
2017 Hu G, Yelamanchili S, Kashanchi F, Haughey N, Bond VC, Witwer KW, Pulliam L, Buch S. Proceedings of the 2017 ISEV symposium on "HIV, NeuroHIV, drug abuse, & EVs". Journal of Neurovirology. PMID 29147885 DOI: 10.1007/S13365-017-0599-8  0.33
2017 Beck SE, Queen SE, Metcalf Pate KA, Mangus LM, Abreu CM, Gama L, Witwer KW, Adams RJ, Zink MC, Clements JE, Mankowski JL. An SIV/macaque model targeted to study HIV-associated neurocognitive disorders. Journal of Neurovirology. PMID 28975505 DOI: 10.1007/S13365-017-0582-4  0.548
2017 Hu G, Witwer KW, Bond VC, Haughey N, Kashanchi F, Pulliam L, Buch S. Proceedings of the ISEV symposium on "HIV, NeuroAIDS, drug abuse & EVs". Journal of Extracellular Vesicles. 6: 1294360. PMID 28800366 DOI: 10.1080/20013078.2017.1294360  0.39
2017 Witwer KW, Zhang CY. Diet-derived microRNAs: unicorn or silver bullet? Genes & Nutrition. 12: 15. PMID 28694875 DOI: 10.1186/S12263-017-0564-4  0.38
2017 Liao Z, Muth DC, Eitan E, Travers M, Learman LN, Lehrmann E, Witwer KW. Serum extracellular vesicle depletion processes affect release and infectivity of HIV-1 in culture. Scientific Reports. 7: 2558. PMID 28566772 DOI: 10.1038/S41598-017-02908-5  0.388
2017 Roda WC, Li MY, Akinwumi MS, Asahchop EL, Gelman BB, Witwer KW, Power C. Modeling brain lentiviral infections during antiretroviral therapy in AIDS. Journal of Neurovirology. PMID 28512685 DOI: 10.1007/S13365-017-0530-3  0.343
2017 Eitan E, Green J, Bodogai M, Mode NA, Bæk R, Jørgensen MM, Freeman DW, Witwer KW, Zonderman AB, Biragyn A, Mattson MP, Noren Hooten N, Evans MK. Age-Related Changes in Plasma Extracellular Vesicle Characteristics and Internalization by Leukocytes. Scientific Reports. 7: 1342. PMID 28465537 DOI: 10.1038/S41598-017-01386-Z  0.313
2017 Mateescu B, Kowal EJ, van Balkom BW, Bartel S, Bhattacharyya SN, Buzás EI, Buck AH, de Candia P, Chow FW, Das S, Driedonks TA, Fernández-Messina L, Haderk F, Hill AF, Jones JC, ... ... Witwer KW, et al. Obstacles and opportunities in the functional analysis of extracellular vesicle RNA - an ISEV position paper. Journal of Extracellular Vesicles. 6: 1286095. PMID 28326170 DOI: 10.1080/20013078.2017.1286095  0.311
2017 Tosar JP, Cayota A, Eitan E, Halushka MK, Witwer KW. Ribonucleic artefacts: are some extracellular RNA discoveries driven by cell culture medium components? Journal of Extracellular Vesicles. 6: 1272832. PMID 28326168 DOI: 10.1080/20013078.2016.1272832  0.308
2016 Aigner A, Buesen R, Gant T, Gooderham N, Greim H, Hackermüller J, Hubesch B, Laffont M, Marczylo E, Meister G, Petrick JS, Rasoulpour RJ, Sauer UG, Schmidt K, Seitz H, ... ... Witwer KW, et al. Advancing the use of noncoding RNA in regulatory toxicology: Report of an ECETOC workshop. Regulatory Toxicology and Pharmacology : Rtp. PMID 27663666 DOI: 10.1016/J.Yrtph.2016.09.018  0.321
2016 Witwer KW, Halushka MK. Towards the Promise of microRNAs - Enhancing reproducibility and rigor in microRNA research. Rna Biology. 0. PMID 27645402 DOI: 10.1080/15476286.2016.1236172  0.4
2016 Auerbach A, Vyas G, Li A, Halushka M, Witwer K. Uptake of dietary milk miRNAs by adult humans: a validation study. F1000research. 5: 721. PMID 27158459 DOI: 10.12688/F1000Research.8548.1  0.419
2016 McCall MN, Baras AS, Crits-Christoph A, Ingersoll R, McAlexander MA, Witwer KW, Halushka MK. A benchmark for microRNA quantification algorithms using the OpenArray platform. Bmc Bioinformatics. 17: 138. PMID 27000067 DOI: 10.1186/S12859-016-0987-8  0.347
2016 Buchanan EL, Espinoza DA, McAlexander MA, Myers SL, Moyer A, Witwer KW. SAMHD1 transcript upregulation during SIV infection of the central nervous system does not associate with reduced viral load. Scientific Reports. 6: 22629. PMID 26936683 DOI: 10.1038/Srep22629  0.37
2016 van Dongen HM, Masoumi N, Witwer KW, Pegtel DM. Extracellular Vesicles Exploit Viral Entry Routes for Cargo Delivery. Microbiology and Molecular Biology Reviews : Mmbr. 80: 369-86. PMID 26935137 DOI: 10.1128/Mmbr.00063-15  0.332
2015 Witwer KW. Contamination or artifacts may explain reports of plant miRNAs in humans. The Journal of Nutritional Biochemistry. 26: 1685. PMID 26456566 DOI: 10.1016/J.Jnutbio.2015.09.004  0.366
2015 Witwer KW, Buchanan EL, Myers SL, McAlexander MA. miRNAs and SAMHD1 regulation in vitro and in a model of HIV CNS disease. Journal of Neuroinflammation. 12: 159. PMID 26337901 DOI: 10.1186/S12974-015-0380-Y  0.46
2015 Lee YJ, Kim V, Muth DC, Witwer KW. Validated MicroRNA Target Databases: An Evaluation. Drug Development Research. 76: 389-96. PMID 26286669 DOI: 10.1002/Ddr.21278  0.391
2015 Muth DC, McAlexander MA, Ostrenga LJ, Pate NM, Izzi JM, Adams RJ, Pate KA, Beck SE, Karim BO, Witwer KW. Potential role of cervicovaginal extracellular particles in diagnosis of endometriosis. Bmc Veterinary Research. 11: 187. PMID 26253321 DOI: 10.1186/S12917-015-0513-7  0.333
2015 El-Diwany R, Wasilewski L, Witwer KW, Bailey JR, Page K, Ray SC, Cox AL, Thomas DL, Balagopal A. Acute Hepatitis C Virus Infection Induces Consistent Changes in Circulating miRNAs that are Associated with Non-Lytic Hepatocyte Release. Journal of Virology. PMID 26157120 DOI: 10.1128/Jvi.00955-15  0.393
2015 Tosar JP, Gámbaro F, Sanguinetti J, Bonilla B, Witwer KW, Cayota A. Assessment of small RNA sorting into different extracellular fractions revealed by high-throughput sequencing of breast cell lines. Nucleic Acids Research. 43: 5601-16. PMID 25940616 DOI: 10.1093/Nar/Gkv432  0.331
2015 Beck SE, Queen SE, Witwer KW, Metcalf Pate KA, Mangus LM, Gama L, Adams RJ, Clements JE, Christine Zink M, Mankowski JL. Paving the path to HIV neurotherapy: Predicting SIV CNS disease. European Journal of Pharmacology. 759: 303-12. PMID 25818747 DOI: 10.1016/J.Ejphar.2015.03.018  0.545
2015 Drewes JL, Meulendyke KA, Liao Z, Witwer KW, Gama L, Ubaida-Mohien C, Li M, Notarangelo FM, Tarwater PM, Schwarcz R, Graham DR, Zink MC. Quinolinic acid/tryptophan ratios predict neurological disease in SIV-infected macaques and remain elevated in the brain under cART. Journal of Neurovirology. PMID 25776527 DOI: 10.1007/S13365-015-0334-2  0.358
2015 Witwer KW. Circulating microRNA biomarker studies: pitfalls and potential solutions. Clinical Chemistry. 61: 56-63. PMID 25391989 DOI: 10.1373/Clinchem.2014.221341  0.41
2015 Buchanan EL, McAlexander MA, Witwer KW. SAMHD1 expression in blood cells of HIV-1 elite suppressors and viraemic progressors. The Journal of Antimicrobial Chemotherapy. 70: 954-6. PMID 25344600 DOI: 10.1093/Jac/Dku428  0.356
2014 Lötvall J, Hill AF, Hochberg F, Buzás EI, Di Vizio D, Gardiner C, Gho YS, Kurochkin IV, Mathivanan S, Quesenberry P, Sahoo S, Tahara H, Wauben MH, Witwer KW, Théry C. Minimal experimental requirements for definition of extracellular vesicles and their functions: a position statement from the International Society for Extracellular Vesicles. Journal of Extracellular Vesicles. 3: 26913. PMID 25536934 DOI: 10.3402/Jev.V3.26913  0.305
2014 Witwer KW. Diet-responsive mammalian miRNAs are likely endogenous. The Journal of Nutrition. 144: 1880-1. PMID 25332488 DOI: 10.3945/Jn.114.202523  0.376
2014 Christofidou-Solomidou M, Pietrofesa R, Arguiri E, McAlexander MA, Witwer KW. Dietary flaxseed modulates the miRNA profile in irradiated and non-irradiated murine lungs: a novel mechanism of tissue radioprotection by flaxseed. Cancer Biology & Therapy. 15: 930-7. PMID 24755684 DOI: 10.4161/Cbt.28905  0.37
2014 Witwer KW, Gama L, Mankowski JL, Zink MC, Clements JE. TRIM19-positive and TRIM19-negative cells in and around a perivascular cuff of CD68-positive macrophages. Aids Research and Human Retroviruses. 30: 333-4. PMID 24697643 DOI: 10.1089/Aid.2014.0029  0.548
2014 Meulendyke KA, Ubaida-Mohien C, Drewes JL, Liao Z, Gama L, Witwer KW, Graham DR, Zink MC. Elevated brain monoamine oxidase activity in SIV- and HIV-associated neurological disease. The Journal of Infectious Diseases. 210: 904-12. PMID 24688074 DOI: 10.1093/Infdis/Jiu194  0.374
2014 Witwer KW. HIV-1 Tat- and Vpr-responsive microRNAs of neuronal cells. The Journal of Biological Chemistry. 289: 3104. PMID 24489003 DOI: 10.1074/Jbc.L113.541755  0.382
2014 Witwer KW, Hirschi KD. Transfer and functional consequences of dietary microRNAs in vertebrates: concepts in search of corroboration: negative results challenge the hypothesis that dietary xenomiRs cross the gut and regulate genes in ingesting vertebrates, but important questions persist. Bioessays : News and Reviews in Molecular, Cellular and Developmental Biology. 36: 394-406. PMID 24436255 DOI: 10.1002/Bies.201300150  0.412
2014 Yu IW, Espinoza DA, McAlexander MA, Witwer KW. OpenArray profiling reveals no differential modulation of miRNA by positive and negative CD4+ T cell immunoselection. Experimental Hematology. 42: 11-3. PMID 24096121 DOI: 10.1016/J.Exphem.2013.09.011  0.428
2014 Gao P, Witwer K, McAlexander M, Tripathi P, Johnson T, Li HH. Circulating Extracellular Micrornas In Hereditary Angioedema Journal of Allergy and Clinical Immunology. 133: AB32. DOI: 10.1016/J.Jaci.2013.12.141  0.389
2013 Liu J, Sisk JM, Gama L, Clements JE, Witwer KW. Tristetraprolin expression and microRNA-mediated regulation during simian immunodeficiency virus infection of the central nervous system. Molecular Brain. 6: 40. PMID 24103357 DOI: 10.1186/1756-6606-6-40  0.581
2013 Witwer KW, Buzás EI, Bemis LT, Bora A, Lässer C, Lötvall J, Nolte-'t Hoen EN, Piper MG, Sivaraman S, Skog J, Théry C, Wauben MH, Hochberg F. Standardization of sample collection, isolation and analysis methods in extracellular vesicle research. Journal of Extracellular Vesicles. 2. PMID 24009894 DOI: 10.3402/Jev.V2I0.20360  0.328
2013 Sisk JM, Witwer KW, Tarwater PM, Clements JE. SIV replication is directly downregulated by four antiviral miRNAs. Retrovirology. 10: 95. PMID 23988154 DOI: 10.1186/1742-4690-10-95  0.621
2013 Witwer KW, McAlexander MA, Queen SE, Adams RJ. Real-time quantitative PCR and droplet digital PCR for plant miRNAs in mammalian blood provide little evidence for general uptake of dietary miRNAs: limited evidence for general uptake of dietary plant xenomiRs. Rna Biology. 10: 1080-6. PMID 23770773 DOI: 10.4161/Rna.25246  0.393
2013 McAlexander MA, Phillips MJ, Witwer KW. Comparison of Methods for miRNA Extraction from Plasma and Quantitative Recovery of RNA from Cerebrospinal Fluid. Frontiers in Genetics. 4: 83. PMID 23720669 DOI: 10.3389/Fgene.2013.00083  0.312
2013 Witwer KW. Data submission and quality in microarray-based microRNA profiling. Clinical Chemistry. 59: 392-400. PMID 23358751 DOI: 10.1373/Clinchem.2012.193813  0.323
2013 Sisk J, Clements J, Witwer K. Witwer, K.W.; et al. Correction: miRNA Profiles of Monocyte-Lineage Cells Are Consistent with Complicated Roles in HIV-1 Restriction. Viruses 2012, 4, 1844-1864. Viruses. 5: 901-901. DOI: 10.3390/V5030901  0.556
2012 Sisk JM, Clements JE, Witwer KW. miRNA profiles of monocyte-lineage cells are consistent with complicated roles in HIV-1 restriction. Viruses. 4: 1844-64. PMID 23202444 DOI: 10.3390/V4101844  0.615
2012 Witwer KW. XenomiRs and miRNA homeostasis in health and disease: evidence that diet and dietary miRNAs directly and indirectly influence circulating miRNA profiles. Rna Biology. 9: 1147-54. PMID 22951590 DOI: 10.4161/Rna.21619  0.407
2012 Witwer KW, Clements JE. Evidence for miRNA expression differences of HIV-1-positive, treatment-naive patients and elite suppressors: a re-analysis. Blood. 119: 6395-6. PMID 22745299 DOI: 10.1182/Blood-2012-02-412742  0.59
2012 Witwer KW, Watson AK, Blankson JN, Clements JE. Relationships of PBMC microRNA expression, plasma viral load, and CD4+ T-cell count in HIV-1-infected elite suppressors and viremic patients. Retrovirology. 9: 5. PMID 22240256 DOI: 10.1186/1742-4690-9-5  0.615
2012 Watson AK, Witwer KW. Do platform-specific factors explain microRNA profiling disparities? Clinical Chemistry. 58: 472-4; author reply . PMID 22048406 DOI: 10.1373/Clinchem.2011.175281  0.397
2011 Co JG, Witwer KW, Gama L, Zink MC, Clements JE. Induction of innate immune responses by SIV in vivo and in vitro: differential expression and function of RIG-I and MDA5. The Journal of Infectious Diseases. 204: 1104-14. PMID 21881126 DOI: 10.1093/Infdis/Jir469  0.534
2011 Witwer KW, Sarbanes SL, Liu J, Clements JE. A plasma microRNA signature of acute lentiviral infection: biomarkers of central nervous system disease. Aids (London, England). 25: 2057-67. PMID 21857495 DOI: 10.1097/Qad.0B013E32834B95Bf  0.602
2010 Witwer KW, Sisk JM, Gama L, Clements JE. MicroRNA regulation of IFN-beta protein expression: rapid and sensitive modulation of the innate immune response. Journal of Immunology (Baltimore, Md. : 1950). 184: 2369-76. PMID 20130213 DOI: 10.4049/Jimmunol.0902712  0.556
2009 Witwer KW, Gama L, Li M, Bartizal CM, Queen SE, Varrone JJ, Brice AK, Graham DR, Tarwater PM, Mankowski JL, Zink MC, Clements JE. Coordinated regulation of SIV replication and immune responses in the CNS. Plos One. 4: e8129. PMID 20019816 DOI: 10.1371/Journal.Pone.0008129  0.556
Low-probability matches (unlikely to be authored by this person)
2020 Xiao Y, Driedonks T, Witwer KW, Wang Q, Yin H. How does an RNA selfie work? EV-associated RNA in innate immunity as self or danger. Journal of Extracellular Vesicles. 9: 1793515. PMID 32944182 DOI: 10.1080/20013078.2020.1793515  0.299
2017 Reiner AT, Witwer KW, van Balkom BWM, de Beer J, Brodie C, Corteling RL, Gabrielsson S, Gimona M, Ibrahim AG, de Kleijn D, Lai CP, Lötvall J, Del Portillo HA, Reischl IG, Riazifar M, et al. Concise Review: Developing Best-Practice Models for the Therapeutic Use of Extracellular Vesicles. Stem Cells Translational Medicine. PMID 28714557 DOI: 10.1002/Sctm.17-0055  0.299
2020 Royo F, Théry C, Falcón-Pérez JM, Nieuwland R, Witwer KW. Methods for Separation and Characterization of Extracellular Vesicles: Results of a Worldwide Survey Performed by the ISEV Rigor and Standardization Subcommittee. Cells. 9. PMID 32854228 DOI: 10.3390/Cells9091955  0.299
2018 Li K, Rodosthenous RS, Kashanchi F, Gingeras T, Gould SJ, Kuo LS, Kurre P, Lee H, Leonard JN, Liu H, Lombo TB, Momma S, Nolan JP, Ochocinska MJ, Pegtel DM, ... ... Witwer KW, et al. Advances, challenges, and opportunities in extracellular RNA biology: insights from the NIH exRNA Strategic Workshop. Jci Insight. 3. PMID 29618663 DOI: 10.1172/Jci.Insight.98942  0.298
2020 Börger V, Weiss DJ, Anderson JD, Borràs FE, Bussolati B, Carter DRF, Dominici M, Falcón-Pérez JM, Gimona M, Hill AF, Hoffman AM, de Kleijn D, Levine BL, Lim R, Lötvall J, ... ... Witwer KW, et al. ISEV and ISCT statement on EVs from MSCs and other cells: considerations for potential therapeutic agents to suppress COVID-19. Cytotherapy. PMID 32425691 DOI: 10.1016/J.Jcyt.2020.05.002  0.297
2017 Dickens AM, Tovar-Y-Romo LB, Yoo SW, Trout AL, Bae M, Kanmogne M, Megra B, Williams DW, Witwer KW, Gacias M, Tabatadze N, Cole RN, Casaccia P, Berman JW, Anthony DC, et al. Astrocyte-shed extracellular vesicles regulate the peripheral leukocyte response to inflammatory brain lesions. Science Signaling. 10. PMID 28377412 DOI: 10.1126/Scisignal.Aai7696  0.296
2019 Liu S, Mahairaki V, Bai H, Ding Z, Li J, Witwer KW, Cheng L. Highly purified human extracellular vesicles produced by stem cells alleviate aging cellular phenotypes of senescent human cells. Stem Cells (Dayton, Ohio). PMID 30811771 DOI: 10.1002/Stem.2996  0.291
2019 Dakhlallah DA, Wisler J, Gencheva M, Brown CM, Leatherman ER, Singh K, Brundage K, Karsies T, Dakhlallah A, Witwer KW, Sen CK, Eubank TD, Marsh CB. Circulating extracellular vesicle content reveals DNA methyltransferase expression as a molecular method to predict septic shock. Journal of Extracellular Vesicles. 8: 1669881. PMID 31632618 DOI: 10.1080/20013078.2019.1669881  0.288
2019 Witwer KW, Van Balkom BWM, Bruno S, Choo A, Dominici M, Gimona M, Hill AF, De Kleijn D, Koh M, Lai RC, Mitsialis SA, Ortiz LA, Rohde E, Asada T, Toh WS, et al. Defining mesenchymal stromal cell (MSC)-derived small extracellular vesicles for therapeutic applications. Journal of Extracellular Vesicles. 8: 1609206. PMID 31069028 DOI: 10.1080/20013078.2019.1609206  0.283
2021 Martin-Jaular L, Nevo N, Schessner JP, Tkach M, Jouve M, Dingli F, Loew D, Witwer KW, Ostrowski M, Borner GHH, Théry C. Unbiased proteomic profiling of host cell extracellular vesicle composition and dynamics upon HIV-1 infection. The Embo Journal. e105492. PMID 33709510 DOI: 10.15252/embj.2020105492  0.282
2017 Van Deun J, Mestdagh P, Agostinis P, Akay Ö, Anand S, Anckaert J, Martinez ZA, Baetens T, Beghein E, Bertier L, Berx G, Boere J, Boukouris S, Bremer M, ... ... Witwer KW, et al. EV-TRACK: transparent reporting and centralizing knowledge in extracellular vesicle research. Nature Methods. 14: 228-232. PMID 28245209 DOI: 10.1038/Nmeth.4185  0.28
2017 Soares RP, Xander P, Costa AO, Marcilla A, Menezes-Neto A, Del Portillo H, Witwer K, Wauben M, Nolte-T Hoen E, Olivier M, Criado MF, da Silva LLP, Abdel Baqui MM, Schenkman S, Colli W, et al. Highlights of the São Paulo ISEV workshop on extracellular vesicles in cross-kingdom communication. Journal of Extracellular Vesicles. 6: 1407213. PMID 30044885 DOI: 10.1080/20013078.2017.1407213  0.279
2019 Russell AE, Sneider A, Witwer KW, Bergese P, Bhattacharyya SN, Cocks A, Cocucci E, Erdbrügger U, Falcon-Perez JM, Freeman DW, Gallagher TM, Hu S, Huang Y, Jay SM, Kano SI, et al. Biological membranes in EV biogenesis, stability, uptake, and cargo transfer: an ISEV position paper arising from the ISEV membranes and EVs workshop. Journal of Extracellular Vesicles. 8: 1684862. PMID 31762963 DOI: 10.1080/20013078.2019.1684862  0.279
2019 Xu J, Wang Y, Hsu CY, Gao Y, Meyers CA, Chang L, Zhang L, Broderick K, Ding C, Peault B, Witwer K, James AW. Human perivascular stem cell-derived extracellular vesicles mediate bone repair. Elife. 8. PMID 31482845 DOI: 10.7554/Elife.48191  0.276
2019 Clayton A, Boilard E, Buzas EI, Cheng L, Falcón-Perez JM, Gardiner C, Gustafson D, Gualerzi A, Hendrix A, Hoffman A, Jones J, Lässer C, Lawson C, Lenassi M, Nazarenko I, ... ... Witwer K, et al. Considerations towards a roadmap for collection, handling and storage of blood extracellular vesicles. Journal of Extracellular Vesicles. 8: 1647027. PMID 31489143 DOI: 10.1080/20013078.2019.1647027  0.275
2018 Bandeira E, Oliveira H, Silva JD, Menna-Barreto RFS, Takyia CM, Suk JS, Witwer KW, Paulaitis ME, Hanes J, Rocco PRM, Morales MM. Therapeutic effects of adipose-tissue-derived mesenchymal stromal cells and their extracellular vesicles in experimental silicosis. Respiratory Research. 19: 104. PMID 29843724 DOI: 10.1186/S12931-018-0802-3  0.273
2015 Eitan E, Zhang S, Witwer KW, Mattson MP. Extracellular vesicle-depleted fetal bovine and human sera have reduced capacity to support cell growth. Journal of Extracellular Vesicles. 4: 26373. PMID 25819213 DOI: 10.3402/Jev.V4.26373  0.272
2018 Fromm B, Kang W, Rovira C, Cayota A, Witwer K, Friedländer MR, Tosar JP. Plant microRNAs in human sera are likely contaminants. The Journal of Nutritional Biochemistry. PMID 30266285 DOI: 10.1016/J.Jnutbio.2018.07.019  0.27
2019 Witwer KW, Théry C. Extracellular vesicles or exosomes? On primacy, precision, and popularity influencing a choice of nomenclature. Journal of Extracellular Vesicles. 8: 1648167. PMID 31489144 DOI: 10.1080/20013078.2019.1648167  0.269
2023 Adhikari R, Witwer KW, Wiberg KJ, Chen YC. The interplay among HIV, monocytes/macrophages, and extracellular vesicles: a systematic review. Journal of Leukocyte Biology. PMID 36802000 DOI: 10.1093/jleuko/qiac021  0.267
2015 Sherman JH, Munyikwa T, Chan SY, Petrick JS, Witwer KW, Choudhuri S. RNAi Technologies in Agricultural Biotechnology: The Toxicology Forum 40(th) Annual Summer Meeting. Regulatory Toxicology and Pharmacology : Rtp. PMID 26361858 DOI: 10.1016/J.Yrtph.2015.09.001  0.266
2016 Gardiner C, Di Vizio D, Sahoo S, Théry C, Witwer KW, Wauben M, Hill AF. Techniques used for the isolation and characterization of extracellular vesicles: results of a worldwide survey. Journal of Extracellular Vesicles. 5: 32945. PMID 27802845 DOI: 10.3402/Jev.V5.32945  0.262
2019 Xu J, Wang Y, Hsu C, Gao Y, Meyers CA, Chang L, Zhang L, Broderick K, Ding C, Peault B, Witwer K, James AW. Author response: Human perivascular stem cell-derived extracellular vesicles mediate bone repair Elife. DOI: 10.7554/Elife.48191.036  0.259
2015 Kim DK, Lee J, Kim SR, Choi DS, Yoon YJ, Kim JH, Go G, Nhung D, Hong K, Jang SC, Kim SH, Park KS, Kim OY, Park HT, Seo JH, ... ... Witwer K, et al. EVpedia: a community web portal for extracellular vesicles research. Bioinformatics (Oxford, England). 31: 933-9. PMID 25388151 DOI: 10.1093/Bioinformatics/Btu741  0.257
2023 Huang Y, Liao Z, Dang P, Queen S, Abreu CM, Gololobova O, Zheng L, Witwer KW. Longitudinal characterization of circulating extracellular vesicles and small RNA during simian immunodeficiency virus infection and antiretroviral therapy. Aids (London, England). PMID 36779477 DOI: 10.1097/QAD.0000000000003487  0.255
2018 Fromm B, Tosar JP, Lu Y, Halushka MK, Witwer KW. Human and Cow Have Identical miR-21-5p and miR-30a-5p Sequences, Which Are Likely Unsuited to Study Dietary Uptake from Cow Milk. The Journal of Nutrition. 148: 1506-1507. PMID 30184228 DOI: 10.1093/Jn/Nxy144  0.254
2016 Aragon Han P, Kim HS, Cho S, Fazeli R, Najafian A, Khawaja H, McAlexander M, Dy B, Sorensen M, Aronova A, Sebo TJ, Giordano TJ, Fahey TJ, Thompson GB, Gauger PG, ... ... Witwer KW, et al. Association of BRAF(V600E) Mutation and MicroRNA Expression with Central Lymph Node Metastases in Papillary Thyroid Cancer: A Prospective Study from Four Endocrine Surgery Centers. Thyroid : Official Journal of the American Thyroid Association. PMID 26950846 DOI: 10.1089/Thy.2015.0378  0.246
2020 Negri S, Wang Y, Sono T, Lee S, Hsu GC, Xu J, Meyers CA, Qin Q, Broderick K, Witwer KW, Peault B, James AW. Human perivascular stem cells prevent bone graft resorption in osteoporotic contexts by inhibiting osteoclast formation. Stem Cells Translational Medicine. PMID 32697440 DOI: 10.1002/Sctm.20-0152  0.246
2016 Wu RT, Cao L, Mattson E, Witwer KW, Cao J, Zeng H, He X, Combs GF, Cheng WH. Opposing impacts on healthspan and longevity by limiting dietary selenium in telomere dysfunctional mice. Aging Cell. PMID 27653523 DOI: 10.1111/Acel.12529  0.245
2023 Huang Y, Abdelgawad A, Turchinovich A, Queen S, Abreu CM, Zhu X, Batish M, Zheng L, Witwer KW. RNA landscapes of brain and brain-derived extracellular vesicles in simian immunodeficiency virus (SIV) infection and central nervous system pathology. The Journal of Infectious Diseases. PMID 38079216 DOI: 10.1093/infdis/jiad563  0.245
2019 Liao Z, Jaular LM, Soueidi E, Jouve M, Muth DC, Schøyen TH, Seale T, Haughey NJ, Ostrowski M, Théry C, Witwer KW. Acetylcholinesterase is not a generic marker of extracellular vesicles. Journal of Extracellular Vesicles. 8: 1628592. PMID 31303981 DOI: 10.1080/20013078.2019.1628592  0.244
2017 Witwer KW, Soekmadji C, Hill AF, Wauben MH, Buzás EI, Di Vizio D, Falcon-Perez JM, Gardiner C, Hochberg F, Kurochkin IV, Lötvall J, Mathivanan S, Nieuwland R, Sahoo S, Tahara H, et al. Updating the MISEV minimal requirements for extracellular vesicle studies: building bridges to reproducibility. Journal of Extracellular Vesicles. 6: 1396823. PMID 29184626 DOI: 10.1080/20013078.2017.1396823  0.243
2023 Powell BH, Turchinovich A, Wang Y, Gololobova O, Buschmann D, Zeiger MA, Umbricht CB, Witwer KW. miR-210 Expression Is Strongly Hypoxia-Induced in Anaplastic Thyroid Cancer Cell Lines and Is Associated with Extracellular Vesicles and Argonaute-2. International Journal of Molecular Sciences. 24. PMID 36901936 DOI: 10.3390/ijms24054507  0.241
2017 Hooten NN, Eitan E, Green J, Bodogai M, Mode NA, Bæk R, Jørgensen MM, Zonderman A, Witwer K, Biragyn A, Mattson M, Evans M. Impact of ageing on plasma extracellular vesicle concentration, protein profile and internalisation by leukocytes Journal of Extracellular Vesicles. 6. PMID 29046763 DOI: 10.1080/20013078.2017.1310414  0.236
2017 Kim V, Mears BM, Powell BH, Witwer KW. Mutant Cas9-transcriptional activator activates HIV-1 in U1 cells in the presence and absence of LTR-specific guide RNAs. Matters. 2017. PMID 28670581  0.229
2020 Lim SK, Giebel B, Weiss DJ, Witwer KW, Rohde E. Re: "Exosomes Derived from Bone Marrow Mesenchymal Stem Cells as Treatment for Severe COVID-19" by Sengupta et al. Stem Cells and Development. PMID 32520641 DOI: 10.1089/Scd.2020.0089  0.228
2018 Poynton SL, Ostrenga L, Witwer KW. Swarming and Aggregation in the Parasitic Diplomonad Flagellate Spironucleus vortens. The Journal of Eukaryotic Microbiology. PMID 30341793 DOI: 10.1111/Jeu.12695  0.223
2021 Tosar JP, Witwer K, Cayota A. Revisiting Extracellular RNA Release, Processing, and Function. Trends in Biochemical Sciences. 46: 438-445. PMID 33413996 DOI: 10.1016/j.tibs.2020.12.008  0.22
2017 Cheng W, Wu RT, Cao L, Witwer KW, Lu H. Dietary Selenium Deprivation Oppositely Impacts Longevity and Healthspan in Telomere Dysfunctional Mice The Faseb Journal. 31. DOI: 10.1096/Fasebj.31.1_Supplement.459.7  0.212
2022 Gomes DE, Witwer KW. L1CAM-associated extracellular vesicles: A systematic review of nomenclature, sources, separation, and characterization. Journal of Extracellular Biology. 1. PMID 35492832 DOI: 10.1002/jex2.35  0.207
2022 Zhu X, Hollinger KR, Huang Y, Borjabad A, Kim BH, Arab T, Thomas AG, Moniruzzaman M, Lovell L, Turchinovich A, Witwer KW, Volsky DJ, Haughey NJ, Slusher BS. Neutral sphingomyelinase 2 inhibition attenuates extracellular vesicle release and improves neurobehavioral deficits in murine HIV. Neurobiology of Disease. 169: 105734. PMID 35462006 DOI: 10.1016/j.nbd.2022.105734  0.203
2021 Saheera S, Jani VP, Witwer KW, Kutty S. Extracellular vesicle interplay in cardiovascular pathophysiology. American Journal of Physiology. Heart and Circulatory Physiology. PMID 33666501 DOI: 10.1152/ajpheart.00925.2020  0.2
2022 Tosar JP, Cayota A, Witwer K. Exomeres and Supermeres: monolithic or diverse? Journal of Extracellular Biology. 1. PMID 36311878 DOI: 10.1002/jex2.45  0.198
2022 Xiao Y, Liang J, Witwer KW, Zhang Y, Wang Q, Yin H. Extracellular vesicle-associated microRNA-30b-5p activates macrophages through the SIRT1/ NF-κB pathway in cell senescence. Frontiers in Immunology. 13: 955175. PMID 36119099 DOI: 10.3389/fimmu.2022.955175  0.197
2022 Davidson SM, Boulanger CM, Aikawa E, Badimon L, Barile L, Binder CJ, Brisson A, Buzas E, Emanueli C, Jansen F, Katsur M, Lacroix R, Lim SK, Mackman N, Mayr M, ... ... Witwer K, et al. Methods for the identification and characterization of extracellular vesicles in cardiovascular studies - from exosomes to microvesicles. Cardiovascular Research. PMID 35325061 DOI: 10.1093/cvr/cvac031  0.193
2019 Witwer KW, Hill AF, Tahara H. Announcing the ISEV2019 special achievement award recipients: Takahiro Ochiya and Marca Wauben. Journal of Extracellular Vesicles. 8: 1620080. PMID 31164970 DOI: 10.1080/20013078.2019.1620080  0.186
2023 Cable J, Witwer KW, Coffey RJ, Milosavljevic A, von Lersner AK, Jimenez L, Pucci F, Barr MM, Dekker N, Barman B, Humphrys D, Williams J, de Palma M, Guo W, Bastos N, et al. Exosomes, microvesicles, and other extracellular vesicles-a Keystone Symposia report. Annals of the New York Academy of Sciences. PMID 36961472 DOI: 10.1111/nyas.14974  0.184
2024 Driedonks TAP, Nyberg LH, Conte A, Ma Z, Pekosz A, Duban E, Tonevitsky A, Sültmann H, Turchinovich A, Witwer KW. Viral and host small RNA transcriptome analysis of SARS-CoV-1 and SARS-CoV-2-infected human cells reveals novel viral short RNAs. Heliyon. 10: e24570. PMID 38314306 DOI: 10.1016/j.heliyon.2024.e24570  0.184
2022 Nieuwland R, Siljander PR, Falcón-Pérez JM, Witwer KW. Reproducibility of extracellular vesicle research. European Journal of Cell Biology. 101: 151226. PMID 35460959 DOI: 10.1016/j.ejcb.2022.151226  0.183
2022 Driedonks T, Jiang L, Carlson B, Han Z, Liu G, Queen SE, Shirk EN, Gololobova O, Liao Z, Nyberg LH, Lima G, Paniushkina L, Garcia-Contreras M, Schonvisky K, Castell N, ... ... Witwer KW, et al. Pharmacokinetics and biodistribution of extracellular vesicles administered intravenously and intranasally to . Journal of Extracellular Biology. 1. PMID 36591537 DOI: 10.1002/jex2.59  0.179
2021 Verweij FJ, Balaj L, Boulanger CM, Carter DRF, Compeer EB, D'Angelo G, El Andaloussi S, Goetz JG, Gross JC, Hyenne V, Krämer-Albers EM, Lai CP, Loyer X, Marki A, Momma S, ... ... Witwer K, et al. The power of imaging to understand extracellular vesicle biology in vivo. Nature Methods. PMID 34446922 DOI: 10.1038/s41592-021-01206-3  0.174
2024 Welsh JA, Goberdhan DCI, O'Driscoll L, Buzas EI, Blenkiron C, Bussolati B, Cai H, Di Vizio D, Driedonks TAP, Erdbrügger U, Falcon-Perez JM, Fu QL, Hill AF, Lenassi M, Lim SK, ... ... Witwer KW, et al. Minimal information for studies of extracellular vesicles (MISEV2023): From basic to advanced approaches. Journal of Extracellular Vesicles. 13: e12404. PMID 38326288 DOI: 10.1002/jev2.12404  0.173
2022 Russell AE, Liao Z, Tkach M, Tarwater PM, Ostrowski M, Théry C, Witwer KW. Cigarette smoke-induced extracellular vesicles from dendritic cells alter T-cell activation and HIV replication. Toxicology Letters. PMID 35181468 DOI: 10.1016/j.toxlet.2022.02.004  0.17
2018 Théry C, Witwer K. ISEV2018 abstract book Journal of Extracellular Vesicles. 7: 1461450. DOI: 10.1080/20013078.2018.1461450  0.169
2023 Adamczyk AM, Leicaj ML, Fabiano MP, Cabrerizo G, Bannoud N, Croci DO, Witwer KW, Remes Lenicov F, Ostrowski M, Pérez PS. Extracellular vesicles from human plasma dampen inflammation and promote tissue repair functions in macrophages. Journal of Extracellular Vesicles. 12: e12331. PMID 37272889 DOI: 10.1002/jev2.12331  0.166
2023 Costa B, Li Calzi M, Castellano M, Blanco V, Cuevasanta E, Litvan I, Ivanov P, Witwer K, Cayota A, Tosar JP. Nicked tRNAs are stable reservoirs of tRNA halves in cells and biofluids. Proceedings of the National Academy of Sciences of the United States of America. 120: e2216330120. PMID 36652478 DOI: 10.1073/pnas.2216330120  0.164
2023 Huang Y, Driedonks TAP, Cheng L, Turchinovich A, Pletniková O, Redding-Ochoa J, Troncoso JC, Hill AF, Mahairaki V, Zheng L, Witwer KW. Small RNA Profiles of Brain Tissue-Derived Extracellular Vesicles in Alzheimer's Disease. Journal of Alzheimer's Disease : Jad. PMID 37781809 DOI: 10.3233/JAD-230872  0.161
2023 Broad K, Walker SA, Davidovich I, Witwer K, Talmon Y, Wolfram J. Unraveling multilayered extracellular vesicles: Speculation on cause. Journal of Extracellular Vesicles. 12: e12309. PMID 36732941 DOI: 10.1002/jev2.12309  0.161
2021 Couch Y, Buzàs EI, Vizio DD, Gho YS, Harrison P, Hill AF, Lötvall J, Raposo G, Stahl PD, Théry C, Witwer KW, Carter DRF. A brief history of nearly EV-erything - The rise and rise of extracellular vesicles. Journal of Extracellular Vesicles. 10: e12144. PMID 34919343 DOI: 10.1002/jev2.12144  0.16
2022 Chen M, Pekosz A, Villano JS, Shen W, Zhou R, Kulaga H, Li Z, Beck SE, Witwer KW, Mankowski JL, Ramanathan M, Rowan NR, Lane AP. Evolution of nasal and olfactory infection characteristics of SARS-CoV-2 variants. Biorxiv : the Preprint Server For Biology. PMID 35441175 DOI: 10.1101/2022.04.12.487379  0.16
2024 Chen M, Pekosz A, Villano JS, Shen W, Zhou R, Kulaga H, Li Z, Smith A, Gurung A, Beck SE, Witwer KW, Mankowski JL, Ramanathan M, Rowan NR, Lane AP. Evolution of nasal and olfactory infection characteristics of SARS-CoV-2 variants. The Journal of Clinical Investigation. PMID 38483537 DOI: 10.1172/JCI174439  0.16
2023 Huang Y, Arab T, Russell AE, Mallick ER, Nagaraj R, Gizzie E, Redding-Ochoa J, Troncoso JC, Pletnikova O, Turchinovich A, Routenberg DA, Witwer KW. Toward a human brain extracellular vesicle atlas: Characteristics of extracellular vesicles from different brain regions, including small RNA and protein profiles. Interdisciplinary Medicine. 1: e20230016. PMID 38089920 DOI: 10.1002/INMD.20230016  0.158
2023 Rodriguez BV, Wen Y, Shirk EN, Vazquez S, Gololobova O, Maxwell A, Plunkard J, Castell N, Carlson B, Queen SE, Izzi JM, Driedonks TAP, Witwer KW. An ex vivo model of interactions between extracellular vesicles and peripheral mononuclear blood cells in whole blood. Journal of Extracellular Vesicles. 12: e12368. PMID 38047476 DOI: 10.1002/jev2.12368  0.158
2024 Basso M, Gori A, Nardella C, Palviainen M, Holcar M, Sotiropoulos I, Bobis-Wozowicz S, D'Agostino VG, Casarotto E, Ciani Y, Suetsugu S, Gualerzi A, Martin-Jaular L, Boselli D, Kashkanova A, ... ... Witwer KW, et al. International Society for Extracellular Vesicles Workshop. QuantitatEVs: multiscale analyses, from bulk to single extracellular vesicle. Journal of Extracellular Biology. 3. PMID 38405579 DOI: 10.1002/jex2.137  0.157
2024 Poupardin R, Wolf M, Maeding N, Paniushkina L, Geissler S, Bergese P, Witwer KW, Schallmoser K, Fuhrmann G, Strunk D. Advances in Extracellular Vesicle Research Over The Past Decade: Source And Isolation Method Are Connected with Cargo And Function. Advanced Healthcare Materials. e2303941. PMID 38270559 DOI: 10.1002/adhm.202303941  0.157
2023 Kwak G, Gololobova O, Sharma N, Caine C, Mazur M, Mulka K, West NE, Solomon GM, Cutting GR, Witwer KW, Rowe SM, Paulaitis M, Aslanidi G, Suk JS. Extracellular vesicles enhance pulmonary transduction of stably associated adeno-associated virus following intratracheal administration. Journal of Extracellular Vesicles. 12: e12324. PMID 37272896 DOI: 10.1002/jev2.12324  0.155
2023 Huang Y, Arab T, Russell AE, Mallick ER, Nagaraj R, Gizzie E, Redding-Ochoa J, Troncoso JC, Pletnikova O, Turchinovich A, Routenberg DA, Witwer KW. Towards a human brain EV atlas: Characteristics of EVs from different brain regions, including small RNA and protein profiles. Biorxiv : the Preprint Server For Biology. PMID 37214955 DOI: 10.1101/2023.05.06.539665  0.154
2023 Islam MK, Khan M, Gidwani K, Witwer KW, Lamminmäki U, Leivo J. Lectins as potential tools for cancer biomarker discovery from extracellular vesicles. Biomarker Research. 11: 85. PMID 37773167 DOI: 10.1186/s40364-023-00520-6  0.149
2020 Nguyen VVT, Witwer KW, Verhaar MC, Strunk D, van Balkom BWM. Functional assays to assess the therapeutic potential of extracellular vesicles. Journal of Extracellular Vesicles. 10: e12033. PMID 33708360 DOI: 10.1002/jev2.12033  0.148
2023 Meng Q, Chen C, Yang N, Gololobova O, Shi C, Dunn CA, Rossi M, Martindale JL, Basisty N, Ding J, Delannoy M, Basu S, Mazan-Mamczarz K, Shin CH, Yang JH, ... ... Witwer KW, et al. Surfaceome analysis of extracellular vesicles from senescent cells uncovers uptake repressor DPP4. Proceedings of the National Academy of Sciences of the United States of America. 120: e2219801120. PMID 37862381 DOI: 10.1073/pnas.2219801120  0.148
2022 Huang Y, Driedonks TAP, Cheng L, Rajapaksha H, Routenberg DA, Nagaraj R, Redding J, Arab T, Powell BH, Pletniková O, Troncoso JC, Zheng L, Hill AF, Mahairaki V, Witwer KW. Brain Tissue-Derived Extracellular Vesicles in Alzheimer's Disease Display Altered Key Protein Levels Including Cell Type-Specific Markers. Journal of Alzheimer's Disease : Jad. PMID 36213994 DOI: 10.3233/JAD-220322  0.148
2023 Li G, Chen T, Dahlman J, Eniola-Adefeso L, Ghiran IC, Kurre P, Lam WA, Lang JK, Marbán E, Martín P, Momma S, Moos M, Nelson DJ, Raffai RL, Ren X, ... ... Witwer KW, et al. Current challenges and future directions for engineering extracellular vesicles for heart, lung, blood and sleep diseases. Journal of Extracellular Vesicles. 12: e12305. PMID 36775986 DOI: 10.1002/jev2.12305  0.147
2021 Witwer KW, Goberdhan DC, O'Driscoll L, Théry C, Welsh JA, Blenkiron C, Buzás EI, Di Vizio D, Erdbrügger U, Falcón-Pérez JM, Fu QL, Hill AF, Lenassi M, Lötvall J, Nieuwland R, et al. Updating MISEV: Evolving the minimal requirements for studies of extracellular vesicles. Journal of Extracellular Vesicles. 10: e12182. PMID 34953156 DOI: 10.1002/jev2.12182  0.139
2022 Morris KV, Witwer KW. The evolving paradigm of extracellular vesicles in intercellular signaling and delivery of therapeutic RNAs. Molecular Therapy : the Journal of the American Society of Gene Therapy. 30: 2393-2394. PMID 35643080 DOI: 10.1016/j.ymthe.2022.05.015  0.138
2021 Gimona M, Brizzi MF, Choo ABH, Dominici M, Davidson SM, Grillari J, Hermann DM, Hill AF, de Kleijn D, Lai RC, Lai CP, Lim R, Monguió-Tortajada M, Muraca M, Ochiya T, ... ... Witwer KW, et al. Critical considerations for the development of potency tests for therapeutic applications of mesenchymal stromal cell-derived small extracellular vesicles. Cytotherapy. 23: 373-380. PMID 33934807 DOI: 10.1016/j.jcyt.2021.01.001  0.136
2020 Dong L, Zieren RC, Horie K, Kim CJ, Mallick E, Jing Y, Feng M, Kuczler MD, Green J, Amend SR, Witwer KW, de Reijke TM, Cho YK, Pienta KJ, Xue W. Comprehensive evaluation of methods for small extracellular vesicles separation from human plasma, urine and cell culture medium. Journal of Extracellular Vesicles. 10: e12044. PMID 33489012 DOI: 10.1002/jev2.12044  0.135
2021 Erdbrügger U, Blijdorp CJ, Bijnsdorp IV, Borràs FE, Burger D, Bussolati B, Byrd JB, Clayton A, Dear JW, Falcón-Pérez JM, Grange C, Hill AF, Holthöfer H, Hoorn EJ, Jenster G, ... ... Witwer K, et al. Urinary extracellular vesicles: A position paper by the Urine Task Force of the International Society for Extracellular Vesicles. Journal of Extracellular Vesicles. 10: e12093. PMID 34035881 DOI: 10.1002/jev2.12093  0.132
2022 Huang Y, Driedonks TAP, Cheng L, Rajapaksha H, Turchinovich A, Routenberg DA, Nagaraj R, Redding-Ochoa J, Arab T, Powell BH, Pletnikova O, Troncoso JC, Zheng L, Hill AF, Mahairaki V, ... Witwer KW, et al. Relationships of Genotypes With Small RNA and Protein Cargo of Brain Tissue Extracellular Vesicles From Patients With Late-Stage AD. Neurology. Genetics. 8: e200026. PMID 36405397 DOI: 10.1212/NXG.0000000000200026  0.131
2022 Mateescu B, Jones JC, Alexander RP, Alsop E, An JY, Asghari M, Boomgarden A, Bouchareychas L, Cayota A, Chang HC, Charest A, Chiu DT, Coffey RJ, Das S, De Hoff P, ... ... Witwer KW, et al. Phase 2 of extracellular RNA communication consortium charts next-generation approaches for extracellular RNA research. Iscience. 25: 104653. PMID 35958027 DOI: 10.1016/j.isci.2022.104653  0.13
2023 Lucien F, Gustafson D, Lenassi M, Li B, Teske JJ, Boilard E, von Hohenberg KC, Falcón-Perez JM, Gualerzi A, Reale A, Jones JC, Lässer C, Lawson C, Nazarenko I, O'Driscoll L, ... ... Witwer KW, et al. MIBlood-EV: Minimal information to enhance the quality and reproducibility of blood extracellular vesicle research. Journal of Extracellular Vesicles. 12: e12385. PMID 38063210 DOI: 10.1002/jev2.12385  0.127
2020 Welsh JA, van der Pol E, Bettin BA, Carter DRF, Hendrix A, Lenassi M, Langlois MA, Llorente A, van de Nes AS, Nieuwland R, Tang V, Wang L, Witwer KW, Jones JC. Towards defining reference materials for measuring extracellular vesicle refractive index, epitope abundance, size and concentration. Journal of Extracellular Vesicles. 9: 1816641. PMID 33062218 DOI: 10.1080/20013078.2020.1816641  0.126
2015 Aragon Han P, Weng CH, Khawaja HT, Nagarajan N, Schneider EB, Umbricht CB, Witwer KW, Zeiger MA. MicroRNA Expression and Association with Clinicopathologic Features in Papillary Thyroid Cancer: A Systematic Review. Thyroid : Official Journal of the American Thyroid Association. PMID 26414548 DOI: 10.1089/thy.2015.0193  0.126
2024 Welsh JA, Goberdhan DC, O'Driscoll L, Théry C, Witwer KW. MISEV2023: An updated guide to EV research and applications. Journal of Extracellular Vesicles. 13: e12416. PMID 38400602 DOI: 10.1002/jev2.12416  0.12
2024 Ahmed SH, AlMoslemany MA, Witwer KW, Tehamy AG, El-Badri N. Stem Cell Extracellular Vesicles as Anti-SARS-CoV-2 Immunomodulatory Therapeutics: A Systematic Review of Clinical and Preclinical Studies. Stem Cell Reviews and Reports. PMID 38393666 DOI: 10.1007/s12015-023-10675-2  0.12
2021 Han Z, Liu S, Pei Y, Ding Z, Li Y, Wang X, Zhan D, Xia S, Driedonks T, Witwer KW, Weiss RG, van Zijl PCM, Bulte JWM, Cheng L, Liu G. Highly efficient magnetic labelling allows MRI tracking of the homing of stem cell-derived extracellular vesicles following systemic delivery. Journal of Extracellular Vesicles. 10: e12054. PMID 33489014 DOI: 10.1002/jev2.12054  0.115
2023 Halushka MK, Witwer KW. Letter by Halushka and Witwer Regarding Article, "Circulating MicroRNA-122-5p Is Associated With a Lack of Improvement in Left Ventricular Function After Transcatheter Aortic Valve Replacement and Regulates Viability of Cardiomyocytes Through Extracellular Vesicles". Circulation. 147: e64-e65. PMID 36689572 DOI: 10.1161/CIRCULATIONAHA.122.061834  0.113
2022 Al-Masawa ME, Alshawsh MA, Ng CY, Ng AMH, Foo JB, Vijakumaran U, Subramaniam R, Ghani NAA, Witwer KW, Law JX. Efficacy and safety of small extracellular vesicle interventions in wound healing and skin regeneration: A systematic review and meta-analysis of animal studies. Theranostics. 12: 6455-6508. PMID 36185607 DOI: 10.7150/thno.73436  0.11
2023 Di Vizio D, Schoppet M, Weeraratna A, Witwer KW. Blebs and former blebs: From surface protrusions to extracellular vesicles in cancer signalling, anoikis resistance and beyond. Journal of Extracellular Biology. 2. PMID 38162121 DOI: 10.1002/jex2.112  0.108
2022 Arifin DR, Witwer KW, Bulte JWM. Non-Invasive imaging of extracellular vesicles: Quo vaditis in vivo? Journal of Extracellular Vesicles. 11: e12241. PMID 35844061 DOI: 10.1002/jev2.12241  0.107
2020 Witwer K. Dietary RNA is ripe for investigation. Nature. 582: S9. PMID 32555472 DOI: 10.1038/d41586-020-01766-y  0.106
2021 Tallon C, Hollinger KR, Pal A, Bell BJ, Rais R, Tsukamoto T, Witwer KW, Haughey NJ, Slusher BS. Nipping disease in the bud: nSMase2 inhibitors as therapeutics in extracellular vesicle-mediated diseases. Drug Discovery Today. PMID 33798648 DOI: 10.1016/j.drudis.2021.03.025  0.103
2022 Jiang L, Driedonks TAP, Jong WSP, Dhakal S, Bart van den Berg van Saparoea H, Sitaras I, Zhou R, Caputo C, Littlefield K, Lowman M, Chen M, Lima G, Gololobova O, Smith B, Mahairaki V, ... ... Witwer KW, et al. A bacterial extracellular vesicle-based intranasal vaccine against SARS-CoV-2 protects against disease and elicits neutralizing antibodies to wild-type and Delta variants. Journal of Extracellular Vesicles. 11: e12192. PMID 35289114 DOI: 10.1002/jev2.12192  0.102
2022 Jiang L, Driedonks TAP, Jong WSP, Dhakal S, van den Berg van Saparoea HB, Sitaras I, Zhou R, Caputo C, Littlefield K, Lowman M, Chen M, Lima G, Gololobova O, Smith B, Mahairaki V, ... ... Witwer KW, et al. A bacterial extracellular vesicle-based intranasal vaccine against SARS-CoV-2 protects against disease and elicits neutralizing antibodies to wild-type and Delta variants. Biorxiv : the Preprint Server For Biology. PMID 35132418 DOI: 10.1101/2021.06.28.450181  0.101
2020 Nieuwland R, Falcón-Pérez JM, Théry C, Witwer KW. Rigor and standardization of extracellular vesicle research: Paving the road towards robustness. Journal of Extracellular Vesicles. 10: e12037. PMID 33343835 DOI: 10.1002/jev2.12037  0.095
2020 Noren Hooten N, Yáñez-Mó M, DeRita R, Russell A, Quesenberry P, Ramratnam B, Robbins PD, Di Vizio D, Wen S, Witwer KW, Languino LR. Hitting the Bullseye: Are extracellular vesicles on target? Journal of Extracellular Vesicles. 10: e12032. PMID 33708359 DOI: 10.1002/jev2.12032  0.095
2021 Avramopoulos D, Kapogiannis D, Leoutsakos JM, Lyketsos CG, Mahairaki V, Nowrangi M, Oishi K, Oh ES, Rosenberg PB, Samus Q, Smith GS, Witwer K, Yasar S, Zandi PP. Developing Treatments for Alzheimer's and Related Disorders with Precision Medicine: A Vision. Advances in Experimental Medicine and Biology. 1339: 395-402. PMID 35023131 DOI: 10.1007/978-3-030-78787-5_49  0.093
2016 Eitan E, Hutchison ER, Marosi K, Comotto J, Mustapic M, Nigam SM, Suire C, Maharana C, Jicha GA, Liu D, Machairaki V, Witwer KW, Kapogiannis D, Mattson MP. Extracellular Vesicle-Associated Aβ Mediates Trans-Neuronal Bioenergetic and Ca(2+)-Handling Deficits in Alzheimer's Disease Models. Npj Aging and Mechanisms of Disease. 2. PMID 27928512 DOI: 10.1038/npjamd.2016.19  0.09
2021 Witwer KW, Wolfram J. Extracellular vesicles versus synthetic nanoparticles for drug delivery. Nature Reviews. Materials. 6: 103-106. PMID 36117545 DOI: 10.1038/s41578-020-00277-6  0.082
2021 Arab T, Mallick ER, Huang Y, Dong L, Liao Z, Zhao Z, Gololobova O, Smith B, Haughey NJ, Pienta KJ, Slusher BS, Tarwater PM, Tosar JP, Zivkovic AM, Vreeland WN, ... ... Witwer KW, et al. Characterization of extracellular vesicles and synthetic nanoparticles with four orthogonal single-particle analysis platforms. Journal of Extracellular Vesicles. 10: e12079. PMID 33850608 DOI: 10.1002/jev2.12079  0.067
2021 Zheng JJ, Agus JK, Hong BV, Tang X, Rhodes CH, Houts HE, Zhu C, Kang JW, Wong M, Xie Y, Lebrilla CB, Mallick E, Witwer KW, Zivkovic AM. Isolation of HDL by sequential flotation ultracentrifugation followed by size exclusion chromatography reveals size-based enrichment of HDL-associated proteins. Scientific Reports. 11: 16086. PMID 34373542 DOI: 10.1038/s41598-021-95451-3  0.061
2021 Witwer KW. On your MARCKS, get set, deliver: Engineering extracellular vesicles. Molecular Therapy : the Journal of the American Society of Gene Therapy. 29: 1664-1665. PMID 33891862 DOI: 10.1016/j.ymthe.2021.04.013  0.059
2020 Weiss DJ, Lim SK, Rohde E, Witwer KW, Giebel B. Weiss Response to Sengupta et al. (DOI: 10.1089/scd.2020.0095). Stem Cells and Development. 29: 1533-1534. PMID 33301389 DOI: 10.1089/scd.2020.0114  0.05
2019 Bernstein ED, Liao Z, Witwer KW. Cytotoxicity of aqueous cigarette smoke extract is affected by properties of pipettes used to prepare the extract. Matters. 2019. PMID 32104671  0.034
2020 Witwer KW, Languino LR, Weaver AM, Wauben MH. Announcing the ISEV2020 special achievement award recipients: Andrew Hill and Edit Buzás; and the recipient of the ISEV2020 special education award: Carolina Soekmadji. Journal of Extracellular Vesicles. 10: e12021. PMID 33304475 DOI: 10.1002/jev2.12021  0.024
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