| Year |
Citation |
Score |
| 2023 |
Ketkar A, Sewilam RS, McCrury MJ, Hall JS, Bell A, Paxton BC, Tripathi S, Gunderson JEC, Eoff RL. Conservation of the insert-2 motif confers Rev1 from different species with an ability to disrupt G-quadruplexes and stimulate translesion DNA synthesis. Rsc Chemical Biology. 4: 466-485. PMID 37415867 DOI: 10.1039/d3cb00027c |
0.372 |
|
| 2022 |
Urbaniak A, Reed MR, Heflin B, Gaydos J, Piña-Oviedo S, Jędrzejczyk M, Klejborowska G, Stępczyńska N, Chambers TC, Tackett AJ, Rodriguez A, Huczyński A, Eoff RL, MacNicol AM. Anti-glioblastoma activity of monensin and its analogs in an organoid model of cancer. Biomedicine & Pharmacotherapy = Biomedecine & Pharmacotherapie. 153: 113440. PMID 36076555 DOI: 10.1016/j.biopha.2022.113440 |
0.504 |
|
| 2021 |
Christov PP, Richie-Jannetta R, Kingsley PJ, Vemulapalli A, Kim K, Sulikowski GA, Rizzo CJ, Ketkar A, Eoff RL, Rouzer CA, Marnett LJ. Site-Specific Synthesis of Oligonucleotides Containing 6-Oxo-MdG, the Genomic Metabolite of MdG, and Liquid Chromatography-Tandem Mass Spectrometry Analysis of Its In Vitro Bypass by Human Polymerase ι. Chemical Research in Toxicology. PMID 34860508 DOI: 10.1021/acs.chemrestox.1c00334 |
0.329 |
|
| 2021 |
Reed MR, Maddukuri L, Ketkar A, Byrum SD, Zafar MK, Bostian ACL, Tackett AJ, Eoff RL. Inhibition of tryptophan 2,3-dioxygenase impairs DNA damage tolerance and repair in glioma cells. Nar Cancer. 3: zcab014. PMID 33870196 DOI: 10.1093/narcan/zcab014 |
0.671 |
|
| 2019 |
Ketkar A, Maddukuri L, Penthala NR, Reed MR, Zafar MK, Crooks PA, Eoff RL. Inhibition of human DNA polymerases eta and kappa by indole-derived molecules occurs through distinct mechanisms. Acs Chemical Biology. PMID 31082191 DOI: 10.1021/Acschembio.9B00304 |
0.528 |
|
| 2019 |
West KL, Kelliher JL, Xu Z, An L, Reed MR, Eoff RL, Wang J, Huen MSY, Leung JWC. LC8/DYNLL1 is a 53BP1 effector and regulates checkpoint activation. Nucleic Acids Research. PMID 30982887 DOI: 10.1093/Nar/Gkz263 |
0.496 |
|
| 2018 |
Zafar MK, Maddukuri L, Ketkar A, Penthala N, Reed MR, Eddy SD, Crooks PA, Eoff RL. A small-molecule inhibitor of human DNA polymerase eta potentiates the effects of cisplatin in tumor cells. Biochemistry. PMID 29345908 DOI: 10.1021/Acs.Biochem.7B01176 |
0.547 |
|
| 2017 |
Zafar MK, Eoff RL. Translesion DNA synthesis in cancer: molecular mechanisms and therapeutic opportunities. Chemical Research in Toxicology. PMID 28841374 DOI: 10.1021/Acs.Chemrestox.7B00157 |
0.507 |
|
| 2017 |
Eoff RL, Raney KD. A catch and release program for single-stranded DNA. The Journal of Biological Chemistry. 292: 13085-13086. PMID 28778884 DOI: 10.1074/Jbc.H117.791392 |
0.731 |
|
| 2017 |
Ketkar A, Voehler M, Mukiza T, Eoff RL. Residues in the RecQ C-terminal Domain of the Human Werner Syndrome Helicase are Involved in Unwinding G-quadruplex DNA. The Journal of Biological Chemistry. PMID 28069813 DOI: 10.1074/Jbc.M116.767699 |
0.509 |
|
| 2016 |
Eddy S, Tillman M, Maddukuri L, Ketkar A, Zafar MK, Eoff RL. Human translesion polymerase kappa exhibits enhanced activity and reduced fidelity two nucleotides from G-quadruplex DNA. Biochemistry. PMID 27525498 DOI: 10.1021/Acs.Biochem.6B00374 |
0.451 |
|
| 2016 |
Bostian AC, Eoff RL. Aberrant kynurenine signaling modulates DNA replication stress factors and promotes genomic instability in gliomas. Chemical Research in Toxicology. PMID 27482758 DOI: 10.1021/Acs.Chemrestox.6B00255 |
0.529 |
|
| 2016 |
Byrd AK, Zybailov BL, Maddukuri L, Gao J, Marecki JC, Jaiswal M, Bell MR, Griffin WC, Reed MR, Chib S, Mackintosh SG, MacNicol AM, Baldini G, Eoff RL, Raney KD. Evidence that G-quadruplex DNA Accumulates in the Cytoplasm and Participates in Stress Granule Assembly in Response to Oxidative Stress. The Journal of Biological Chemistry. PMID 27369081 DOI: 10.1074/Jbc.M116.718478 |
0.701 |
|
| 2016 |
Yeom M, Kim IH, Kim JK, Kang K, Eoff RL, Guengerich FP, Choi JY. Effects of Twelve Germline Missense Variations on DNA Lesion and G-Quadruplex Bypass Activities of Human DNA Polymerase REV1. Chemical Research in Toxicology. PMID 26914252 DOI: 10.1021/Acs.Chemrestox.5B00513 |
0.505 |
|
| 2015 |
Bostian AC, Maddukuri L, Reed MR, Savenka T, Hartman JH, Davis LE, Pouncey DL, Miller GP, Eoff RL. Kynurenine signaling increases DNA polymerase kappa expression and promotes genomic instability in glioblastoma cells. Chemical Research in Toxicology. PMID 26651356 DOI: 10.1021/Acs.Chemrestox.5B00452 |
0.471 |
|
| 2015 |
Eddy S, Maddukuri L, Ketkar A, Zafar MK, Henninger EE, Pursell ZF, Eoff RL. Evidence for the kinetic partitioning of polymerase activity on G-quadruplex DNA. Biochemistry. 54: 3218-30. PMID 25903680 DOI: 10.1021/Acs.Biochem.5B00060 |
0.487 |
|
| 2014 |
Maddukuri L, Ketkar A, Eddy S, Zafar MK, Eoff RL. The Werner syndrome protein limits the error-prone 8-oxo-dG lesion bypass activity of human DNA polymerase kappa. Nucleic Acids Research. 42: 12027-40. PMID 25294835 DOI: 10.1093/Nar/Gku913 |
0.513 |
|
| 2014 |
Zafar MK, Ketkar A, Lodeiro MF, Cameron CE, Eoff RL. Kinetic analysis of human PrimPol DNA polymerase activity reveals a generally error-prone enzyme capable of accurately bypassing 7,8-dihydro-8-oxo-2'-deoxyguanosine. Biochemistry. 53: 6584-94. PMID 25255211 DOI: 10.1021/Bi501024U |
0.611 |
|
| 2014 |
Kim J, Song I, Jo A, Shin JH, Cho H, Eoff RL, Guengerich FP, Choi JY. Biochemical analysis of six genetic variants of error-prone human DNA polymerase ι involved in translesion DNA synthesis. Chemical Research in Toxicology. 27: 1837-52. PMID 25162224 DOI: 10.1021/Tx5002755 |
0.507 |
|
| 2014 |
Zhao L, Pence MG, Eoff RL, Yuan S, Fercu CA, Guengerich FP. Elucidation of kinetic mechanisms of human translesion DNA polymerase κ using tryptophan mutants. The Febs Journal. 281: 4394-410. PMID 25065501 DOI: 10.1111/Febs.12947 |
0.455 |
|
| 2014 |
Eddy S, Ketkar A, Zafar MK, Maddukuri L, Choi JY, Eoff RL. Human Rev1 polymerase disrupts G-quadruplex DNA. Nucleic Acids Research. 42: 3272-85. PMID 24366879 DOI: 10.1093/Nar/Gkt1314 |
0.562 |
|
| 2013 |
Maddukuri L, Shuck SC, Eoff RL, Zhao L, Rizzo CJ, Guengerich FP, Marnett LJ. Replication, repair, and translesion polymerase bypass of N⁶-oxopropenyl-2'-deoxyadenosine. Biochemistry. 52: 8766-76. PMID 24171480 DOI: 10.1021/Bi401103K |
0.593 |
|
| 2013 |
Schaetzlein S, Chahwan R, Avdievich E, Roa S, Wei K, Eoff RL, Sellers RS, Clark AB, Kunkel TA, Scharff MD, Edelmann W. Mammalian Exo1 encodes both structural and catalytic functions that play distinct roles in essential biological processes. Proceedings of the National Academy of Sciences of the United States of America. 110: E2470-9. PMID 23754438 DOI: 10.1073/Pnas.1308512110 |
0.501 |
|
| 2013 |
Coggins GE, Maddukuri L, Penthala NR, Hartman JH, Eddy S, Ketkar A, Crooks PA, Eoff RL. N-Aroyl indole thiobarbituric acids as inhibitors of DNA repair and replication stress response polymerases. Acs Chemical Biology. 8: 1722-9. PMID 23679919 DOI: 10.1021/Cb400305R |
0.447 |
|
| 2013 |
Ketkar A, Zafar MK, Maddukuri L, Yamanaka K, Banerjee S, Egli M, Choi JY, Lloyd RS, Eoff RL. Leukotriene biosynthesis inhibitor MK886 impedes DNA polymerase activity. Chemical Research in Toxicology. 26: 221-32. PMID 23305233 DOI: 10.1021/Tx300392M |
0.589 |
|
| 2012 |
Yamanaka K, Dorjsuren D, Eoff RL, Egli M, Maloney DJ, Jadhav A, Simeonov A, Lloyd RS. A comprehensive strategy to discover inhibitors of the translesion synthesis DNA polymerase κ. Plos One. 7: e45032. PMID 23056190 DOI: 10.1371/Journal.Pone.0045032 |
0.55 |
|
| 2012 |
Ketkar A, Zafar MK, Banerjee S, Marquez VE, Egli M, Eoff RL. Differential furanose selection in the active sites of archaeal DNA polymerases probed by fixed-conformation nucleotide analogues. Biochemistry. 51: 9234-44. PMID 23050956 DOI: 10.1021/Bi301043K |
0.495 |
|
| 2012 |
Maddukuri L, Ketkar A, Eddy S, Zafar MK, Griffin WC, Eoff RL. Enhancement of human DNA polymerase η activity and fidelity is dependent upon a bipartite interaction with the Werner syndrome protein. The Journal of Biological Chemistry. 287: 42312-23. PMID 23045531 DOI: 10.1074/Jbc.M112.410332 |
0.772 |
|
| 2012 |
Ketkar A, Zafar MK, Banerjee S, Marquez VE, Egli M, Eoff RL. A nucleotide-analogue-induced gain of function corrects the error-prone nature of human DNA polymerase iota. Journal of the American Chemical Society. 134: 10698-705. PMID 22632140 DOI: 10.1021/Ja304176Q |
0.564 |
|
| 2012 |
Adedeji AO, Marchand B, Te Velthuis AJ, Snijder EJ, Weiss S, Eoff RL, Singh K, Sarafianos SG. Mechanism of nucleic acid unwinding by SARS-CoV helicase. Plos One. 7: e36521. PMID 22615777 DOI: 10.1371/Journal.Pone.0036521 |
0.456 |
|
| 2012 |
Yamanaka K, Dorjsuren D, Eoff RL, Egli M, Maloney DJ, Jadhav A, Simeonov A, Lloyd RS. Dose-response activities of (A) candesartan cilexetil, (B) manoalide, and (C) MK-886 on adducted DNAs. Plos One. DOI: 10.1371/Journal.Pone.0045032.G005 |
0.427 |
|
| 2011 |
Choi JY, Eoff RL, Pence MG, Wang J, Martin MV, Kim EJ, Folkmann LM, Guengerich FP. Roles of the four DNA polymerases of the crenarchaeon Sulfolobus solfataricus and accessory proteins in DNA replication. The Journal of Biological Chemistry. 286: 31180-93. PMID 21784862 DOI: 10.1074/Jbc.M111.258038 |
0.592 |
|
| 2011 |
Choi JY, Eoff RL, Pence MG, Wang J, Martin MV, Kim EJ, Folkmann LM, Guengerich FP. Roles of the four DNA polymerases of the crenarchaeon Sulfolobus solfataricus and accessory proteins in DNA replication (Journal of Biological Chemistry (2011) 286, (1180-31193)) Journal of Biological Chemistry. 286: 39674. DOI: 10.1074/jbc.A111.258038 |
0.489 |
|
| 2011 |
Choi JY, Eoff RL, Guengerich FP. Bypass DNA polymerases Current Cancer Research. 6: 345-373. DOI: 10.1007/978-1-61737-995-6_16 |
0.503 |
|
| 2010 |
Eoff RL, Choi JY, Guengerich FP. Mechanistic Studies with DNA Polymerases Reveal Complex Outcomes following Bypass of DNA Damage. Journal of Nucleic Acids. 2010. PMID 20936119 DOI: 10.4061/2010/830473 |
0.591 |
|
| 2010 |
Irimia A, Loukachevitch LV, Eoff RL, Guengerich FP, Egli M. Metal-ion dependence of the active-site conformation of the translesion DNA polymerase Dpo4 from Sulfolobus solfataricus. Acta Crystallographica. Section F, Structural Biology and Crystallization Communications. 66: 1013-8. PMID 20823515 DOI: 10.1107/S1744309110029374 |
0.512 |
|
| 2010 |
Eoff RL, McGrath CE, Maddukuri L, Salamanca-Pinzón SG, Marquez VE, Marnett LJ, Guengerich FP, Egli M. Selective modulation of DNA polymerase activity by fixed-conformation nucleoside analogues. Angewandte Chemie (International Ed. in English). 49: 7481-5. PMID 20814997 DOI: 10.1002/Anie.201003168 |
0.569 |
|
| 2010 |
Maddukuri L, Eoff RL, Choi JY, Rizzo CJ, Guengerich FP, Marnett LJ. In vitro bypass of the major malondialdehyde- and base propenal-derived DNA adduct by human Y-family DNA polymerases κ, ι, and Rev1. Biochemistry. 49: 8415-24. PMID 20726503 DOI: 10.1021/Bi1009024 |
0.444 |
|
| 2010 |
Eoff RL, Raney KD. Kinetic mechanism for DNA unwinding by multiple molecules of Dda helicase aligned on DNA. Biochemistry. 49: 4543-53. PMID 20408588 DOI: 10.1021/Bi100061V |
0.712 |
|
| 2010 |
Eoff RL, Egli M, Guengerich P. Impact of Chemical Adducts on Translesion Synthesis in Replicative and Bypass DNA Polymerases: From Structure to Function The Chemical Biology of Dna Damage. 299-330. DOI: 10.1002/9783527630110.ch13 |
0.413 |
|
| 2009 |
Zhang H, Eoff RL, Kozekov ID, Rizzo CJ, Egli M, Guengerich FP. Structure-function relationships in miscoding by Sulfolobus solfataricus DNA polymerase Dpo4: guanine N2,N2-dimethyl substitution produces inactive and miscoding polymerase complexes. The Journal of Biological Chemistry. 284: 17687-99. PMID 19542237 DOI: 10.1074/Jbc.M109014274 |
0.302 |
|
| 2009 |
Irimia A, Eoff RL, Guengerich FP, Egli M. Structural and functional elucidation of the mechanism promoting error-prone synthesis by human DNA polymerase kappa opposite the 7,8-dihydro-8-oxo-2'-deoxyguanosine adduct. The Journal of Biological Chemistry. 284: 22467-80. PMID 19542228 DOI: 10.1074/Jbc.M109.003905 |
0.488 |
|
| 2009 |
Eoff RL, Sanchez-Ponce R, Guengerich FP. Conformational changes during nucleotide selection by Sulfolobus solfataricus DNA polymerase Dpo4. The Journal of Biological Chemistry. 284: 21090-9. PMID 19515847 DOI: 10.1074/Jbc.M109.009506 |
0.432 |
|
| 2009 |
Eoff RL, Stafford JB, Szekely J, Rizzo CJ, Egli M, Guengerich FP, Marnett LJ. Structural and functional analysis of Sulfolobus solfataricus Y-family DNA polymerase Dpo4-catalyzed bypass of the malondialdehyde-deoxyguanosine adduct. Biochemistry. 48: 7079-88. PMID 19492857 DOI: 10.1021/Bi9003588 |
0.544 |
|
| 2009 |
Voehler MW, Eoff RL, McDonald WH, Guengerich FP, Stone MP. Modulation of the structure, catalytic activity, and fidelity of African swine fever virus DNA polymerase X by a reversible disulfide switch. The Journal of Biological Chemistry. 284: 18434-44. PMID 19419958 DOI: 10.1074/Jbc.M109.012542 |
0.386 |
|
| 2009 |
Choi JY, Lim S, Eoff RL, Guengerich FP. Kinetic analysis of base-pairing preference for nucleotide incorporation opposite template pyrimidines by human DNA polymerase iota. Journal of Molecular Biology. 389: 264-74. PMID 19376129 DOI: 10.1016/J.Jmb.2009.04.023 |
0.518 |
|
| 2009 |
Pallan PS, Prakash TP, Li F, Eoff RL, Manoharan M, Egli M. A conformational transition in the structure of a 2'-thiomethyl-modified DNA visualized at high resolution. Chemical Communications (Cambridge, England). 2017-9. PMID 19333476 DOI: 10.1039/B822781K |
0.421 |
|
| 2009 |
Stafford JB, Eoff RL, Kozekova A, Rizzo CJ, Guengerich FP, Marnett LJ. Translesion DNA synthesis by human DNA polymerase eta on templates containing a pyrimidopurinone deoxyguanosine adduct, 3-(2'-deoxy-beta-d-erythro-pentofuranosyl)pyrimido-[1,2-a]purin-10(3H)-one. Biochemistry. 48: 471-80. PMID 19108641 DOI: 10.1021/Bi801591A |
0.482 |
|
| 2009 |
Zhang H, Eoff RL, Kozekov ID, Rizzo CJ, Egli M, Guengerich FP. Versatility of Y-family Sulfolobus solfataricus DNA polymerase Dpo4 in translesion synthesis past bulky N2-alkylguanine adducts. The Journal of Biological Chemistry. 284: 3563-76. PMID 19059910 DOI: 10.1074/Jbc.M807778200 |
0.422 |
|
| 2007 |
Irimia A, Eoff RL, Pallan PS, Guengerich FP, Egli M. Structure and activity of Y-class DNA polymerase DPO4 from Sulfolobus solfataricus with templates containing the hydrophobic thymine analog 2,4-difluorotoluene. The Journal of Biological Chemistry. 282: 36421-33. PMID 17951245 DOI: 10.1074/Jbc.M707267200 |
0.538 |
|
| 2007 |
Eoff RL, Irimia A, Angel KC, Egli M, Guengerich FP. Hydrogen bonding of 7,8-dihydro-8-oxodeoxyguanosine with a charged residue in the little finger domain determines miscoding events in Sulfolobus solfataricus DNA polymerase Dpo4. The Journal of Biological Chemistry. 282: 19831-43. PMID 17468100 DOI: 10.1074/Jbc.M702290200 |
0.368 |
|
| 2007 |
Eoff RL, Angel KC, Egli M, Guengerich FP. Molecular basis of selectivity of nucleoside triphosphate incorporation opposite O6-benzylguanine by sulfolobus solfataricus DNA polymerase Dpo4: steady-state and pre-steady-state kinetics and x-ray crystallography of correct and incorrect pairing. The Journal of Biological Chemistry. 282: 13573-84. PMID 17337730 DOI: 10.1074/Jbc.M700656200 |
0.379 |
|
| 2007 |
Eoff RL, Irimia A, Egli M, Guengerich FP. Sulfolobus solfataricus DNA polymerase Dpo4 is partially inhibited by "wobble" pairing between O6-methylguanine and cytosine, but accurate bypass is preferred. The Journal of Biological Chemistry. 282: 1456-67. PMID 17105728 DOI: 10.1074/Jbc.M609661200 |
0.336 |
|
| 2006 |
Sikora B, Eoff RL, Matson SW, Raney KD. DNA unwinding by Escherichia coli DNA helicase I (TraI) provides evidence for a processive monomeric molecular motor. The Journal of Biological Chemistry. 281: 36110-6. PMID 16984922 DOI: 10.1074/Jbc.M604412200 |
0.741 |
|
| 2006 |
Irimia A, Zang H, Loukachevitch LV, Eoff RL, Guengerich FP, Egli M. Calcium is a cofactor of polymerization but inhibits pyrophosphorolysis by the Sulfolobus solfataricus DNA polymerase Dpo4. Biochemistry. 45: 5949-56. PMID 16681366 DOI: 10.1021/Bi052511+ |
0.398 |
|
| 2006 |
Eoff RL, Raney KD. Intermediates revealed in the kinetic mechanism for DNA unwinding by a monomeric helicase. Nature Structural & Molecular Biology. 13: 242-9. PMID 16474403 DOI: 10.1038/Nsmb1055 |
0.725 |
|
| 2006 |
Spurling TL, Eoff RL, Raney KD. Dda helicase unwinds a DNA-PNA chimeric substrate: evidence for an inchworm mechanism. Bioorganic & Medicinal Chemistry Letters. 16: 1816-20. PMID 16439125 DOI: 10.1016/J.Bmcl.2006.01.013 |
0.741 |
|
| 2005 |
Eoff RL, Raney KD. Helicase-catalysed translocation and strand separation. Biochemical Society Transactions. 33: 1474-8. PMID 16246149 DOI: 10.1042/Bst20051474 |
0.653 |
|
| 2005 |
Eoff RL, Spurling TL, Raney KD. Chemically modified DNA substrates implicate the importance of electrostatic interactions for DNA unwinding by Dda helicase. Biochemistry. 44: 666-74. PMID 15641792 DOI: 10.1021/Bi0484926 |
0.719 |
|
| 2002 |
Nanduri B, Byrd AK, Eoff RL, Tackett AJ, Raney KD. Pre-steady-state DNA unwinding by bacteriophage T4 Dda helicase reveals a monomeric molecular motor. Proceedings of the National Academy of Sciences of the United States of America. 99: 14722-7. PMID 12411580 DOI: 10.1073/Pnas.232401899 |
0.765 |
|
| 2001 |
Nanduri B, Eoff RL, Tackett AJ, Raney KD. Measurement of steady-state kinetic parameters for DNA unwinding by the bacteriophage T4 Dda helicase: use of peptide nucleic acids to trap single-stranded DNA products of helicase reactions. Nucleic Acids Research. 29: 2829-35. PMID 11433029 DOI: 10.1093/Nar/29.13.2829 |
0.779 |
|
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