Robert L. Eoff, Ph.D. - Publications

Affiliations: 
2005 University of Arkansas for Medical Sciences, United States 
Area:
Biochemistry, Molecular Biology

57 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2017 Eoff RL, Raney KD. A catch and release program for single-stranded DNA. The Journal of Biological Chemistry. 292: 13085-13086. PMID 28778884 DOI: 10.1074/jbc.H117.791392  1
2016 Byrd AK, Zybailov BL, Maddukuri L, Gao J, Marecki JC, Jaiswal M, Bell MR, Griffin WC, Reed MR, Chib S, Mackintosh SG, MacNicol AM, Baldini G, Eoff RL, Raney KD. Evidence that G-quadruplex DNA Accumulates in the Cytoplasm and Participates in Stress Granule Assembly in Response to Oxidative Stress. The Journal of Biological Chemistry. PMID 27369081 DOI: 10.1074/jbc.M116.718478  1
2016 Madadi NR, Ketkar A, Penthala NR, Bostian AC, Eoff RL, Crooks PA. Dioxol and dihydrodioxin analogs of 2- and 3-phenylacetonitriles as potent anti-cancer agents with nanomolar activity against a variety of human cancer cells. Bioorganic & Medicinal Chemistry Letters. PMID 27017113 DOI: 10.1016/j.bmcl.2016.03.068  1
2016 Yeom M, Kim IH, Kim JK, Kang K, Eoff RL, Guengerich FP, Choi JY. Effects of Twelve Germline Missense Variations on DNA Lesion and G-Quadruplex Bypass Activities of Human DNA Polymerase REV1. Chemical Research in Toxicology. PMID 26914252 DOI: 10.1021/acs.chemrestox.5b00513  1
2015 Bostian AC, Maddukuri L, Reed MR, Savenka T, Hartman JH, Davis LE, Pouncey DL, Miller GP, Eoff RL. Kynurenine signaling increases DNA polymerase kappa expression and promotes genomic instability in glioblastoma cells. Chemical Research in Toxicology. PMID 26651356 DOI: 10.1021/acs.chemrestox.5b00452  1
2015 Penthala NR, Ketkar A, Sekhar KR, Freeman ML, Eoff RL, Balusu R, Crooks PA. 1-Benzyl-2-methyl-3-indolylmethylene barbituric acid derivatives: Anti-cancer agents that target nucleophosmin 1 (NPM1). Bioorganic & Medicinal Chemistry. PMID 26602084 DOI: 10.1016/j.bmc.2015.10.019  1
2015 Madadi NR, Penthala NR, Howk K, Ketkar A, Eoff RL, Borrelli MJ, Crooks PA. Synthesis and biological evaluation of novel 4,5-disubstituted 2H-1,2,3-triazoles as cis-constrained analogues of combretastatin A-4. European Journal of Medicinal Chemistry. 103: 123-32. PMID 26352674 DOI: 10.1016/j.ejmech.2015.08.041  1
2015 Madadi NR, Zong H, Ketkar A, Zheng C, Penthala NR, Janganati V, Bommagani S, Eoff RL, Guzman ML, Crooks PA. Synthesis and evaluation of a series of resveratrol analogues as potent anti-cancer agents that target tubulin. Medchemcomm. 6: 788-794. PMID 26257861 DOI: 10.1039/C4MD00478G  1
2015 Eddy S, Maddukuri L, Ketkar A, Zafar MK, Henninger EE, Pursell ZF, Eoff RL. Evidence for the kinetic partitioning of polymerase activity on G-quadruplex DNA. Biochemistry. 54: 3218-30. PMID 25903680 DOI: 10.1021/acs.biochem.5b00060  1
2015 Penthala NR, Zong H, Ketkar A, Madadi NR, Janganati V, Eoff RL, Guzman ML, Crooks PA. Synthesis, anticancer activity and molecular docking studies on a series of heterocyclic trans-cyanocombretastatin analogues as antitubulin agents. European Journal of Medicinal Chemistry. 92: 212-20. PMID 25557492 DOI: 10.1016/j.ejmech.2014.12.050  1
2015 Penthala NR, Madhukuri L, Thakkar S, Madadi NR, Lamture G, Eoff RL, Crooks PA. Synthesis and anti-cancer screening of novel heterocyclic-(2H)-1,2,3-triazoles as potential anti-cancer agents Medchemcomm. 6: 1535-1543. DOI: 10.1039/c5md00219b  1
2014 Maddukuri L, Ketkar A, Eddy S, Zafar MK, Eoff RL. The Werner syndrome protein limits the error-prone 8-oxo-dG lesion bypass activity of human DNA polymerase kappa. Nucleic Acids Research. 42: 12027-40. PMID 25294835 DOI: 10.1093/nar/gku913  1
2014 Zafar MK, Ketkar A, Lodeiro MF, Cameron CE, Eoff RL. Kinetic analysis of human PrimPol DNA polymerase activity reveals a generally error-prone enzyme capable of accurately bypassing 7,8-dihydro-8-oxo-2'-deoxyguanosine. Biochemistry. 53: 6584-94. PMID 25255211 DOI: 10.1021/bi501024u  1
2014 Kim J, Song I, Jo A, Shin JH, Cho H, Eoff RL, Guengerich FP, Choi JY. Biochemical analysis of six genetic variants of error-prone human DNA polymerase ι involved in translesion DNA synthesis. Chemical Research in Toxicology. 27: 1837-52. PMID 25162224 DOI: 10.1021/tx5002755  1
2014 Zhao L, Pence MG, Eoff RL, Yuan S, Fercu CA, Guengerich FP. Elucidation of kinetic mechanisms of human translesion DNA polymerase κ using tryptophan mutants. The Febs Journal. 281: 4394-410. PMID 25065501 DOI: 10.1111/febs.12947  1
2014 Eddy S, Ketkar A, Zafar MK, Maddukuri L, Choi JY, Eoff RL. Human Rev1 polymerase disrupts G-quadruplex DNA. Nucleic Acids Research. 42: 3272-85. PMID 24366879 DOI: 10.1093/nar/gkt1314  1
2013 Maddukuri L, Shuck SC, Eoff RL, Zhao L, Rizzo CJ, Guengerich FP, Marnett LJ. Replication, repair, and translesion polymerase bypass of N⁶-oxopropenyl-2'-deoxyadenosine. Biochemistry. 52: 8766-76. PMID 24171480 DOI: 10.1021/bi401103k  1
2013 Schaetzlein S, Chahwan R, Avdievich E, Roa S, Wei K, Eoff RL, Sellers RS, Clark AB, Kunkel TA, Scharff MD, Edelmann W. Mammalian Exo1 encodes both structural and catalytic functions that play distinct roles in essential biological processes. Proceedings of the National Academy of Sciences of the United States of America. 110: E2470-9. PMID 23754438 DOI: 10.1073/pnas.1308512110  1
2013 Coggins GE, Maddukuri L, Penthala NR, Hartman JH, Eddy S, Ketkar A, Crooks PA, Eoff RL. N-Aroyl indole thiobarbituric acids as inhibitors of DNA repair and replication stress response polymerases. Acs Chemical Biology. 8: 1722-9. PMID 23679919 DOI: 10.1021/cb400305r  1
2013 Ketkar A, Zafar MK, Maddukuri L, Yamanaka K, Banerjee S, Egli M, Choi JY, Lloyd RS, Eoff RL. Leukotriene biosynthesis inhibitor MK886 impedes DNA polymerase activity. Chemical Research in Toxicology. 26: 221-32. PMID 23305233 DOI: 10.1021/tx300392m  1
2012 Yamanaka K, Dorjsuren D, Eoff RL, Egli M, Maloney DJ, Jadhav A, Simeonov A, Lloyd RS. A comprehensive strategy to discover inhibitors of the translesion synthesis DNA polymerase κ. Plos One. 7: e45032. PMID 23056190 DOI: 10.1371/journal.pone.0045032  1
2012 Ketkar A, Zafar MK, Banerjee S, Marquez VE, Egli M, Eoff RL. Differential furanose selection in the active sites of archaeal DNA polymerases probed by fixed-conformation nucleotide analogues. Biochemistry. 51: 9234-44. PMID 23050956 DOI: 10.1021/bi301043k  1
2012 Maddukuri L, Ketkar A, Eddy S, Zafar MK, Griffin WC, Eoff RL. Enhancement of human DNA polymerase η activity and fidelity is dependent upon a bipartite interaction with the Werner syndrome protein. The Journal of Biological Chemistry. 287: 42312-23. PMID 23045531 DOI: 10.1074/jbc.M112.410332  1
2012 Ketkar A, Zafar MK, Banerjee S, Marquez VE, Egli M, Eoff RL. A nucleotide-analogue-induced gain of function corrects the error-prone nature of human DNA polymerase iota. Journal of the American Chemical Society. 134: 10698-705. PMID 22632140 DOI: 10.1021/ja304176q  1
2012 Adedeji AO, Marchand B, Te Velthuis AJ, Snijder EJ, Weiss S, Eoff RL, Singh K, Sarafianos SG. Mechanism of nucleic acid unwinding by SARS-CoV helicase. Plos One. 7: e36521. PMID 22615777 DOI: 10.1371/journal.pone.0036521  1
2011 Choi JY, Eoff RL, Pence MG, Wang J, Martin MV, Kim EJ, Folkmann LM, Guengerich FP. Roles of the four DNA polymerases of the crenarchaeon Sulfolobus solfataricus and accessory proteins in DNA replication. The Journal of Biological Chemistry. 286: 31180-93. PMID 21784862 DOI: 10.1074/jbc.M111.258038  1
2011 Choi JY, Eoff RL, Pence MG, Wang J, Martin MV, Kim EJ, Folkmann LM, Guengerich FP. Roles of the four DNA polymerases of the crenarchaeon Sulfolobus solfataricus and accessory proteins in DNA replication (Journal of Biological Chemistry (2011) 286, (1180-31193)) Journal of Biological Chemistry. 286: 39674. DOI: 10.1074/jbc.A111.258038  1
2011 Choi JY, Eoff RL, Guengerich FP. Bypass DNA polymerases Current Cancer Research. 6: 345-373. DOI: 10.1007/978-1-61737-995-6_16  1
2010 Eoff RL, Choi JY, Guengerich FP. Mechanistic Studies with DNA Polymerases Reveal Complex Outcomes following Bypass of DNA Damage. Journal of Nucleic Acids. 2010. PMID 20936119 DOI: 10.4061/2010/830473  1
2010 Irimia A, Loukachevitch LV, Eoff RL, Guengerich FP, Egli M. Metal-ion dependence of the active-site conformation of the translesion DNA polymerase Dpo4 from Sulfolobus solfataricus. Acta Crystallographica. Section F, Structural Biology and Crystallization Communications. 66: 1013-8. PMID 20823515 DOI: 10.1107/S1744309110029374  1
2010 Eoff RL, McGrath CE, Maddukuri L, Salamanca-Pinzón SG, Marquez VE, Marnett LJ, Guengerich FP, Egli M. Selective modulation of DNA polymerase activity by fixed-conformation nucleoside analogues. Angewandte Chemie (International Ed. in English). 49: 7481-5. PMID 20814997 DOI: 10.1002/anie.201003168  1
2010 Maddukuri L, Eoff RL, Choi JY, Rizzo CJ, Guengerich FP, Marnett LJ. In vitro bypass of the major malondialdehyde- and base propenal-derived DNA adduct by human Y-family DNA polymerases κ, ι, and Rev1. Biochemistry. 49: 8415-24. PMID 20726503 DOI: 10.1021/bi1009024  1
2010 Eoff RL, Raney KD. Kinetic mechanism for DNA unwinding by multiple molecules of Dda helicase aligned on DNA. Biochemistry. 49: 4543-53. PMID 20408588 DOI: 10.1021/bi100061v  1
2010 Eoff RL, Egli M, Guengerich P. Impact of Chemical Adducts on Translesion Synthesis in Replicative and Bypass DNA Polymerases: From Structure to Function The Chemical Biology of Dna Damage. 299-330. DOI: 10.1002/9783527630110.ch13  1
2009 Zhang H, Eoff RL, Kozekov ID, Rizzo CJ, Egli M, Guengerich FP. Structure-function relationships in miscoding by Sulfolobus solfataricus DNA polymerase Dpo4: guanine N2,N2-dimethyl substitution produces inactive and miscoding polymerase complexes. The Journal of Biological Chemistry. 284: 17687-99. PMID 19542237 DOI: 10.1074/jbc.M109014274  1
2009 Irimia A, Eoff RL, Guengerich FP, Egli M. Structural and functional elucidation of the mechanism promoting error-prone synthesis by human DNA polymerase kappa opposite the 7,8-dihydro-8-oxo-2'-deoxyguanosine adduct. The Journal of Biological Chemistry. 284: 22467-80. PMID 19542228 DOI: 10.1074/jbc.M109.003905  1
2009 Eoff RL, Sanchez-Ponce R, Guengerich FP. Conformational changes during nucleotide selection by Sulfolobus solfataricus DNA polymerase Dpo4. The Journal of Biological Chemistry. 284: 21090-9. PMID 19515847 DOI: 10.1074/jbc.M109.009506  1
2009 Eoff RL, Stafford JB, Szekely J, Rizzo CJ, Egli M, Guengerich FP, Marnett LJ. Structural and functional analysis of Sulfolobus solfataricus Y-family DNA polymerase Dpo4-catalyzed bypass of the malondialdehyde-deoxyguanosine adduct. Biochemistry. 48: 7079-88. PMID 19492857 DOI: 10.1021/bi9003588  1
2009 Voehler MW, Eoff RL, McDonald WH, Guengerich FP, Stone MP. Modulation of the structure, catalytic activity, and fidelity of African swine fever virus DNA polymerase X by a reversible disulfide switch. The Journal of Biological Chemistry. 284: 18434-44. PMID 19419958 DOI: 10.1074/jbc.M109.012542  1
2009 Choi JY, Lim S, Eoff RL, Guengerich FP. Kinetic analysis of base-pairing preference for nucleotide incorporation opposite template pyrimidines by human DNA polymerase iota. Journal of Molecular Biology. 389: 264-74. PMID 19376129 DOI: 10.1016/j.jmb.2009.04.023  1
2009 Pallan PS, Prakash TP, Li F, Eoff RL, Manoharan M, Egli M. A conformational transition in the structure of a 2'-thiomethyl-modified DNA visualized at high resolution. Chemical Communications (Cambridge, England). 2017-9. PMID 19333476 DOI: 10.1039/b822781k  1
2009 Stafford JB, Eoff RL, Kozekova A, Rizzo CJ, Guengerich FP, Marnett LJ. Translesion DNA synthesis by human DNA polymerase eta on templates containing a pyrimidopurinone deoxyguanosine adduct, 3-(2'-deoxy-beta-d-erythro-pentofuranosyl)pyrimido-[1,2-a]purin-10(3H)-one. Biochemistry. 48: 471-80. PMID 19108641 DOI: 10.1021/bi801591a  1
2009 Zhang H, Eoff RL, Kozekov ID, Rizzo CJ, Egli M, Guengerich FP. Versatility of Y-family Sulfolobus solfataricus DNA polymerase Dpo4 in translesion synthesis past bulky N2-alkylguanine adducts. The Journal of Biological Chemistry. 284: 3563-76. PMID 19059910 DOI: 10.1074/jbc.M807778200  1
2008 Isin EM, Sohl CD, Eoff RL, Guengerich FP. Cooperativity of cytochrome P450 1A2: interactions of 1,4-phenylene diisocyanide and 1-isopropoxy-4-nitrobenzene. Archives of Biochemistry and Biophysics. 473: 69-75. PMID 18328798 DOI: 10.1016/j.abb.2008.02.033  1
2008 Sohl CD, Isin EM, Eoff RL, Marsch GA, Stec DF, Guengerich FP. Cooperativity in oxidation reactions catalyzed by cytochrome P450 1A2: highly cooperative pyrene hydroxylation and multiphasic kinetics of ligand binding. The Journal of Biological Chemistry. 283: 7293-308. PMID 18187423 DOI: 10.1074/jbc.M709783200  1
2007 Irimia A, Eoff RL, Pallan PS, Guengerich FP, Egli M. Structure and activity of Y-class DNA polymerase DPO4 from Sulfolobus solfataricus with templates containing the hydrophobic thymine analog 2,4-difluorotoluene. The Journal of Biological Chemistry. 282: 36421-33. PMID 17951245 DOI: 10.1074/jbc.M707267200  1
2007 Eoff RL, Irimia A, Angel KC, Egli M, Guengerich FP. Hydrogen bonding of 7,8-dihydro-8-oxodeoxyguanosine with a charged residue in the little finger domain determines miscoding events in Sulfolobus solfataricus DNA polymerase Dpo4. The Journal of Biological Chemistry. 282: 19831-43. PMID 17468100 DOI: 10.1074/jbc.M702290200  1
2007 Eoff RL, Angel KC, Egli M, Guengerich FP. Molecular basis of selectivity of nucleoside triphosphate incorporation opposite O6-benzylguanine by sulfolobus solfataricus DNA polymerase Dpo4: steady-state and pre-steady-state kinetics and x-ray crystallography of correct and incorrect pairing. The Journal of Biological Chemistry. 282: 13573-84. PMID 17337730 DOI: 10.1074/jbc.M700656200  1
2007 Eoff RL, Irimia A, Egli M, Guengerich FP. Sulfolobus solfataricus DNA polymerase Dpo4 is partially inhibited by "wobble" pairing between O6-methylguanine and cytosine, but accurate bypass is preferred. The Journal of Biological Chemistry. 282: 1456-67. PMID 17105728 DOI: 10.1074/jbc.M609661200  1
2006 Sikora B, Eoff RL, Matson SW, Raney KD. DNA unwinding by Escherichia coli DNA helicase I (TraI) provides evidence for a processive monomeric molecular motor. The Journal of Biological Chemistry. 281: 36110-6. PMID 16984922 DOI: 10.1074/jbc.M604412200  1
2006 Irimia A, Zang H, Loukachevitch LV, Eoff RL, Guengerich FP, Egli M. Calcium is a cofactor of polymerization but inhibits pyrophosphorolysis by the Sulfolobus solfataricus DNA polymerase Dpo4. Biochemistry. 45: 5949-56. PMID 16681366 DOI: 10.1021/bi052511+  1
2006 Eoff RL, Raney KD. Intermediates revealed in the kinetic mechanism for DNA unwinding by a monomeric helicase. Nature Structural & Molecular Biology. 13: 242-9. PMID 16474403 DOI: 10.1038/nsmb1055  1
2006 Spurling TL, Eoff RL, Raney KD. Dda helicase unwinds a DNA-PNA chimeric substrate: evidence for an inchworm mechanism. Bioorganic & Medicinal Chemistry Letters. 16: 1816-20. PMID 16439125 DOI: 10.1016/j.bmcl.2006.01.013  1
2005 Eoff RL, Raney KD. Helicase-catalysed translocation and strand separation. Biochemical Society Transactions. 33: 1474-8. PMID 16246149 DOI: 10.1042/BST20051474  1
2005 Eoff RL, Spurling TL, Raney KD. Chemically modified DNA substrates implicate the importance of electrostatic interactions for DNA unwinding by Dda helicase. Biochemistry. 44: 666-74. PMID 15641792 DOI: 10.1021/bi0484926  1
2002 Nanduri B, Byrd AK, Eoff RL, Tackett AJ, Raney KD. Pre-steady-state DNA unwinding by bacteriophage T4 Dda helicase reveals a monomeric molecular motor. Proceedings of the National Academy of Sciences of the United States of America. 99: 14722-7. PMID 12411580 DOI: 10.1073/pnas.232401899  1
2001 Nanduri B, Eoff RL, Tackett AJ, Raney KD. Measurement of steady-state kinetic parameters for DNA unwinding by the bacteriophage T4 Dda helicase: use of peptide nucleic acids to trap single-stranded DNA products of helicase reactions. Nucleic Acids Research. 29: 2829-35. PMID 11433029  1
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