Roddy S. O'Connor, Ph.D. - Publications

Affiliations: 
2007 Emory University, Atlanta, GA 
Area:
Cell Biology, Physiology Biology, Molecular Biology

35 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2021 Tu VY, Ayari A, O'Connor RS. Beyond the Lactate Paradox: How Lactate and Acidity Impact T Cell Therapies against Cancer. Antibodies (Basel, Switzerland). 10. PMID 34203136 DOI: 10.3390/antib10030025  0.01
2021 Tu VY, Ayari A, O'Connor RS. Beyond the Lactate Paradox: How Lactate and Acidity Impact T Cell Therapies against Cancer. Antibodies (Basel, Switzerland). 10. PMID 34203136 DOI: 10.3390/antib10030025  0.01
2021 Durgin JS, Henderson F, Nasrallah MP, Mohan S, Wang S, Lacey SF, Melenhorst JJ, Desai AS, Lee JYK, Maus MV, June CH, Brem S, O'Connor RS, Binder Z, O'Rourke DM. Case Report: Prolonged Survival Following EGFRvIII CAR T Cell Treatment for Recurrent Glioblastoma. Frontiers in Oncology. 11: 669071. PMID 34026647 DOI: 10.3389/fonc.2021.669071  0.01
2021 Safarzadeh Kozani P, Safarzadeh Kozani P, O'Connor RS. In like a lamb; out like a lion: Marching CAR-T cells towards enhanced efficacy in ALL. Molecular Cancer Therapeutics. PMID 33903140 DOI: 10.1158/1535-7163.MCT-20-1089  0.01
2021 Rodriguez-Garcia A, Lynn RC, Poussin M, Eiva MA, Shaw LC, O'Connor RS, Minutolo NG, Casado-Medrano V, Lopez G, Matsuyama T, Powell DJ. CAR-T cell-mediated depletion of immunosuppressive tumor-associated macrophages promotes endogenous antitumor immunity and augments adoptive immunotherapy. Nature Communications. 12: 877. PMID 33563975 DOI: 10.1038/s41467-021-20893-2  0.01
2021 Fraietta JA, Lacey SF, Orlando EJ, Pruteanu-Malinici I, Gohil M, Lundh S, Boesteanu AC, Wang Y, O'Connor RS, Hwang WT, Pequignot E, Ambrose DE, Zhang C, Wilcox N, Bedoya F, et al. Author Correction: Determinants of response and resistance to CD19 chimeric antigen receptor (CAR) T cell therapy of chronic lymphocytic leukemia. Nature Medicine. PMID 33547459 DOI: 10.1038/s41591-021-01248-2  0.01
2020 Ayari A, O'Connor RS. Citius, Altius, Fortius: Performance in a Bottle for CAR T-Cells. Journal of Clinical Haematology. 1: 103-106. PMID 33554221 DOI: 10.33696/haematology.1.015  0.01
2020 Das RK, O'Connor RS, Grupp SA, Barrett DM. Lingering effects of chemotherapy on mature T cells impair proliferation. Blood Advances. 4: 4653-4664. PMID 33002133 DOI: 10.1182/bloodadvances.2020001797  0.01
2020 Varner EL, Trefely S, Bartee D, von Krusenstiern E, Izzo L, Bekeova C, O'Connor RS, Seifert EL, Wellen KE, Meier JL, Snyder NW. Quantification of lactoyl-CoA (lactyl-CoA) by liquid chromatography mass spectrometry in mammalian cells and tissues. Open Biology. 10: 200187. PMID 32961073 DOI: 10.1098/rsob.200187  0.01
2020 Ghassemi S, Martinez-Becerra FJ, Master AM, Richman SA, Heo D, Leferovich J, Tu Y, García-Cañaveras JC, Ayari A, Lu Y, Wang A, Rabinowitz JD, Milone MC, June CH, O'Connor RS. Enhancing Chimeric Antigen Receptor T Cell Anti-tumor Function through Advanced Media Design. Molecular Therapy. Methods & Clinical Development. 18: 595-606. PMID 32775494 DOI: 10.1016/J.Omtm.2020.07.008  0.01
2020 Klichinsky M, Ruella M, Shestova O, Lu XM, Best A, Zeeman M, Schmierer M, Gabrusiewicz K, Anderson NR, Petty NE, Cummins KD, Shen F, Shan X, Veliz K, Blouch K, et al. Human chimeric antigen receptor macrophages for cancer immunotherapy. Nature Biotechnology. PMID 32361713 DOI: 10.1038/S41587-020-0462-Y  0.01
2020 Philipson BI, O'Connor RS, May MJ, June CH, Albelda SM, Milone MC. 4-1BB costimulation promotes CAR T cell survival through noncanonical NF-κB signaling. Science Signaling. 13. PMID 32234960 DOI: 10.1126/Scisignal.Aay8248  0.01
2020 O'Connor RS, Milone MC. Testing the Specificity of Compounds Designed to Inhibit CPT1A in T Cells. Methods in Molecular Biology (Clifton, N.J.). 2097: 83-90. PMID 31776920 DOI: 10.1007/978-1-0716-0203-4_5  0.01
2019 Sellmyer MA, Richman SA, Lohith K, Hou C, Weng CC, Mach RH, O'Connor RS, Milone MC, Farwell MD. Imaging CAR T Cell Trafficking with eDFHR as a PET Reporter Gene. Molecular Therapy : the Journal of the American Society of Gene Therapy. PMID 31668558 DOI: 10.1016/J.Ymthe.2019.10.007  0.01
2019 Liu M, O'Connor RS, Trefely S, Graham K, Snyder NW, Beatty GL. Metabolic rewiring of macrophages by CpG potentiates clearance of cancer cells and overcomes tumor-expressed CD47-mediated 'don't-eat-me' signal. Nature Immunology. PMID 30664738 DOI: 10.1038/S41590-018-0292-Y  0.01
2018 Ghassemi S, Nunez-Cruz S, O'Connor RS, Fraietta JA, Patel PR, Scholler J, Barrett DM, Lundh SM, Davis MM, Bedoya F, Leferovich J, Lacey SF, Levine BL, Grupp SA, June CH, et al. Reducing Ex Vivo Culture Improves the Anti-leukemic Activity of Chimeric Antigen Receptor (CAR)-T Cells. Cancer Immunology Research. PMID 30030295 DOI: 10.1158/2326-6066.Cir-17-0405  0.01
2018 Fraietta JA, Lacey SF, Orlando EJ, Pruteanu-Malinici I, Gohil M, Lundh S, Boesteanu AC, Wang Y, O'Connor RS, Hwang WT, Pequignot E, Ambrose DE, Zhang C, Wilcox N, Bedoya F, et al. Determinants of response and resistance to CD19 chimeric antigen receptor (CAR) T cell therapy of chronic lymphocytic leukemia. Nature Medicine. PMID 29713085 DOI: 10.1038/S41591-018-0010-1  0.01
2018 O'Connor RS, Guo L, Ghassemi S, Snyder NW, Worth AJ, Weng L, Kam Y, Philipson B, Trefely S, Nunez-Cruz S, Blair IA, June CH, Milone MC. The CPT1a inhibitor, etomoxir induces severe oxidative stress at commonly used concentrations. Scientific Reports. 8: 6289. PMID 29674640 DOI: 10.1038/S41598-018-24676-6  0.01
2018 June CH, O'Connor RS, Kawalekar OU, Ghassemi S, Milone MC. CAR T cell immunotherapy for human cancer. Science (New York, N.Y.). 359: 1361-1365. PMID 29567707 DOI: 10.1126/Science.Aar6711  0.01
2017 Hippen KL, O'Connor RS, Lemire AM, Saha A, Hanse EA, Tennis NC, Merkel SC, Kelekar A, Riley JL, Levine BL, June CH, Kean LS, MacMillan ML, Miller JS, Wagner JE, et al. In vitro induction of human regulatory T-cells (iTregs) using conditions of low tryptophan plus kynurenines. American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons. PMID 28470889 DOI: 10.1182/Blood.V128.22.1229.1229  0.01
2017 Lambert L, Goebrecht GK, De Leo SE, O'Connor RS, Nunez-Cruz S, Li TD, Yuan J, Milone MC, Kam LC. Improving T Cell Expansion with a Soft Touch. Nano Letters. PMID 28122453 DOI: 10.1021/Acs.Nanolett.6B04071  0.01
2016 Saha A, O'Connor RS, Thangavelu G, Lovitch SB, Dandamudi DB, Wilson CB, Vincent BG, Tkachev V, Pawlicki JM, Furlan SN, Kean LS, Aoyama K, Taylor PA, Panoskaltsis-Mortari A, Foncea R, et al. Programmed death ligand-1 expression on donor T cells drives graft-versus-host disease lethality. The Journal of Clinical Investigation. PMID 27294527 DOI: 10.1172/Jci85796  0.92
2016 Hu J, Gondarenko A, Dang A, Bashour K, O'Connor R, Lee S, Liapis A, Ghassemi S, Milone M, Sheetz MP, Dustin ML, Kam LC, Hone JC. High throughput mechanobiology screening platform using micro- and nano-topography. Nano Letters. PMID 26990380 DOI: 10.1021/Acs.Nanolett.5B04364  0.92
2016 Kawalekar OU, O'Connor RS, Fraietta JA, Guo L, McGettigan SE, Posey AD, Patel PR, Guedan S, Scholler J, Keith B, Snyder N, Blair I, Milone MC, June CH. Distinct Signaling of Coreceptors Regulates Specific Metabolism Pathways and Impacts Memory Development in CAR T Cells. Immunity. 44: 380-390. PMID 26885860 DOI: 10.1016/J.Immuni.2016.01.021  0.01
2015 Xiang Y, Stine ZE, Xia J, Lu Y, O'Connor RS, Altman BJ, Hsieh AL, Gouw AM, Thomas AG, Gao P, Sun L, Song L, Yan B, Slusher BS, Zhuo J, et al. Targeted inhibition of tumor-specific glutaminase diminishes cell-autonomous tumorigenesis. The Journal of Clinical Investigation. 125: 2293-306. PMID 25915584 DOI: 10.1172/Jci75836  0.92
2014 O'Connor RS, Hails RS, Thomas JA. Accounting for habitat when considering climate: Has the niche of the Adonis blue butterfly changed in the UK? Oecologia. 174: 1463-1472. PMID 24414235 DOI: 10.1007/s00442-013-2850-1  0.01
2012 O'Connor RS, Hao X, Shen K, Bashour K, Akimova T, Hancock WW, Kam LC, Milone MC. Substrate rigidity regulates human T cell activation and proliferation. Journal of Immunology (Baltimore, Md. : 1950). 189: 1330-9. PMID 22732590 DOI: 10.4049/jimmunol.1102757  0.01
2012 Babich A, Li S, O'Connor RS, Milone MC, Freedman BD, Burkhardt JK. F-actin polymerization and retrograde flow drive sustained PLCγ1 signaling during T cell activation. The Journal of Cell Biology. 197: 775-87. PMID 22665519 DOI: 10.1083/Jcb.201201018  0.92
2011 Reichek JL, Duan F, Smith LM, Gustafson DM, O'Connor RS, Zhang C, Dunlevy MJ, Gastier-Foster JM, Barr FG. Genomic and clinical analysis of amplification of the 13q31 chromosomal region in alveolar rhabdomyosarcoma: a report from the Children's Oncology Group. Clinical Cancer Research : An Official Journal of the American Association For Cancer Research. 17: 1463-73. PMID 21220470 DOI: 10.1158/1078-0432.Ccr-10-0091  0.92
2008 O'Connor RS, Steeds CM, Wiseman RW, Pavlath GK. Phosphocreatine as an energy source for actin cytoskeletal rearrangements during myoblast fusion. The Journal of Physiology. 586: 2841-53. PMID 18420707 DOI: 10.1113/Jphysiol.2008.151027  0.92
2007 O'Connor RS, Pavlath GK, McCarthy JJ, Esser KA. Last Word on Point:Counterpoint: Satellite cell addition is/is not obligatory for skeletal muscle hypertrophy. Journal of Applied Physiology (Bethesda, Md. : 1985). 103: 1107. PMID 17724310 DOI: 10.1152/Japplphysiol.00502.2007  0.92
2007 O'Connor RS, Pavlath GK. Point:Counterpoint: Satellite cell addition is/is not obligatory for skeletal muscle hypertrophy. Journal of Applied Physiology (Bethesda, Md. : 1985). 103: 1099-100. PMID 17289912 DOI: 10.1152/Japplphysiol.00101.2007  0.92
2007 O'Connor RS, Mills ST, Jones KA, Ho SN, Pavlath GK. A combinatorial role for NFAT5 in both myoblast migration and differentiation during skeletal muscle myogenesis. Journal of Cell Science. 120: 149-59. PMID 17164296 DOI: 10.1242/Jcs.03307  0.92
2006 Mitchell PO, Mills T, O'Connor RS, Kline ER, Graubert T, Dzierzak E, Pavlath GK. Corrigendum to "Sca-1 negatively regulates proliferation and differentiation of muscle cells" [Dev. Biol. 283 (2005) 240-252] (DOI:10.1016/j.ydbio.2005.04.016) Developmental Biology. 300: 785. DOI: 10.1016/J.Ydbio.2006.10.031  0.92
2005 Mitchell PO, Mills T, O'Connor RS, Kline ER, Graubert T, Dzierzak E, Pavlath GK. Sca-1 negatively regulates proliferation and differentiation of muscle cells. Developmental Biology. 283: 240-52. PMID 15901485 DOI: 10.1016/J.Ydbio.2005.04.016  0.92
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