| Year |
Citation |
Score |
| 2023 |
Jurgelewicz A, Nault R, Harkema J, Zacharewski TR, LaPres JJ. Characterizing the impact of simvastatin co-treatment of cell specific TCDD-induced gene expression and systemic toxicity. Scientific Reports. 13: 16598. PMID 37789023 DOI: 10.1038/s41598-023-42972-8 |
0.768 |
|
| 2023 |
Orlowska K, Fling RR, Nault R, Schilmiller AL, Zacharewski TR. Cystine/Glutamate Xc Antiporter Induction Compensates for Transsulfuration Pathway Repression by 2,3,7,8-Tetrachlorodibenzo--dioxin (TCDD) to Ensure Cysteine for Hepatic Glutathione Biosynthesis. Chemical Research in Toxicology. PMID 37184393 DOI: 10.1021/acs.chemrestox.3c00017 |
0.805 |
|
| 2021 |
Fling RR, Zacharewski TR. Aryl Hydrocarbon Receptor (AhR) Activation by 2,3,7,8-Tetrachlorodibenzo--Dioxin (TCDD) Dose-Dependently Shifts the Gut Microbiome Consistent with the Progression of Non-Alcoholic Fatty Liver Disease. International Journal of Molecular Sciences. 22. PMID 34830313 DOI: 10.3390/ijms222212431 |
0.828 |
|
| 2021 |
Cholico GN, Fling RR, Zacharewski NA, Fader KA, Nault R, Zacharewski TR. Thioesterase induction by 2,3,7,8-tetrachlorodibenzo-p-dioxin results in a futile cycle that inhibits hepatic β-oxidation. Scientific Reports. 11: 15689. PMID 34344994 DOI: 10.1038/s41598-021-95214-0 |
0.795 |
|
| 2020 |
Fling RR, Doskey CM, Fader KA, Nault R, Zacharewski TR. 2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD) dysregulates hepatic one carbon metabolism during the progression of steatosis to steatohepatitis with fibrosis in mice. Scientific Reports. 10: 14831. PMID 32908189 DOI: 10.1038/S41598-020-71795-0 |
0.828 |
|
| 2020 |
Nault R, Fader KA, Bhattacharya S, Zacharewski TR. Single nuclei RNA sequencing assessment of the hepatic effects of 2,3,7,8-tetrachlorodibenzo-p-dioxin. Cellular and Molecular Gastroenterology and Hepatology. PMID 32791302 DOI: 10.1016/J.Jcmgh.2020.07.012 |
0.771 |
|
| 2020 |
Doskey CM, Fader KA, Nault R, Lydic T, Matthews J, Potter D, Sharratt B, Williams K, Zacharewski T. 2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD) alters hepatic polyunsaturated fatty acid metabolism and eicosanoid biosynthesis in female Sprague-Dawley rats. Toxicology and Applied Pharmacology. 115034. PMID 32387183 DOI: 10.1016/J.Taap.2020.115034 |
0.835 |
|
| 2019 |
Nault R, Bals B, Teymouri F, Black MB, Andersen ME, McMullen PD, Krishnan S, Kuravadi N, Paul N, Kumar S, Kannan K, Jayachandra KC, Alagappan L, Patel BD, Bogen KT, ... ... Zacharewski TR, et al. A toxicogenomic approach for the risk assessment of the food contaminant acetamide. Toxicology and Applied Pharmacology. 114872. PMID 31881176 DOI: 10.1016/J.Taap.2019.114872 |
0.768 |
|
| 2019 |
Josyula N, Andersen ME, Kaminski NE, Dere E, Zacharewski TR, Bhattacharya S. Gene co-regulation and co-expression in the aryl hydrocarbon receptor-mediated transcriptional regulatory network in the mouse liver. Archives of Toxicology. PMID 31728591 DOI: 10.1007/S00204-019-02620-5 |
0.686 |
|
| 2019 |
Dornbos P, Jurgelewicz A, Fader KA, Williams K, Zacharewski TR, LaPres JJ. Characterizing the Role of HMG-CoA Reductase in Aryl Hydrocarbon Receptor-Mediated Liver Injury in C57BL/6 Mice. Scientific Reports. 9: 15828. PMID 31676775 DOI: 10.1038/S41598-019-52001-2 |
0.787 |
|
| 2019 |
Fader KA, Nault R, Doskey CM, Fling RR, Zacharewski TR. 2,3,7,8-Tetrachlorodibenzo-p-dioxin abolishes circadian regulation of hepatic metabolic activity in mice. Scientific Reports. 9: 6514. PMID 31015483 DOI: 10.1038/S41598-019-42760-3 |
0.817 |
|
| 2018 |
Nault R, Doskey CM, Fader KA, Rockwell CE, Zacharewski TR. Comparison of hepatic NRF2 and AHR binding in 2,3,7,8-tetrachlorodibenzo--dioxin (TCDD) treated mice demonstrates NRF2-independent PKM2 induction. Molecular Pharmacology. PMID 29752288 DOI: 10.1124/Mol.118.112144 |
0.837 |
|
| 2018 |
Fader KA, Nault R, Raehtz S, McCabe LR, Zacharewski TR. 2,3,7,8-Tetrachlorodibenzo-p-dioxin dose-dependently increases bone mass and decreases marrow adiposity in juvenile mice. Toxicology and Applied Pharmacology. PMID 29673856 DOI: 10.1016/J.Taap.2018.04.013 |
0.783 |
|
| 2018 |
Fader KA, Nault R, Kirby MP, Markous G, Matthews J, Zacharewski TR. Corrigendum to "Convergence of hepcidin deficiency, systemic iron overloading, heme accumulation, and REV-ERBα/β activation in aryl hydrocarbon receptor-elicited hepatotoxicity" [Toxicol Appl Pharmacol. 321 (2017) 1-17]. Toxicology and Applied Pharmacology. PMID 29501526 DOI: 10.1016/J.Taap.2018.03.001 |
0.762 |
|
| 2017 |
Fader KA, Zacharewski TR. Beyond the Aryl Hydrocarbon Receptor: Pathway Interactions in the Hepatotoxicity of 2,3,7,8-Tetrachlorodibenzo-p-dioxin and Related Compounds. Current Opinion in Toxicology. 2: 36-41. PMID 28948239 DOI: 10.1016/J.Cotox.2017.01.010 |
0.773 |
|
| 2017 |
Nault R, Fader KA, Harkema JR, Zacharewski T. Loss of liver-specific and sexually dimorphic gene expression by aryl hydrocarbon receptor activation in C57BL/6 mice. Plos One. 12. PMID 28922406 DOI: 10.1371/Journal.Pone.0184842 |
0.832 |
|
| 2017 |
Fader KA, Nault R, Zhang C, Kumagai K, Harkema JR, Zacharewski TR. 2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD)-elicited effects on bile acid homeostasis: Alterations in biosynthesis, enterohepatic circulation, and microbial metabolism. Scientific Reports. 7: 5921. PMID 28725001 DOI: 10.1038/S41598-017-05656-8 |
0.805 |
|
| 2017 |
Stedtfeld RD, Stedtfeld TM, Fader KA, Williams MR, Bhaduri P, Quensen J, Zacharewski TR, Tiedje JM, Hashsham SA. TCDD influences reservoir of antibiotic resistance genes in murine gut microbiome. Fems Microbiology Ecology. PMID 28475713 DOI: 10.1093/Femsec/Fix058 |
0.76 |
|
| 2017 |
Nault R, Fader KA, Lydic TA, Zacharewski TR. Lipidomic evaluation of aryl hydrocarbon receptor-mediated hepatic steatosis in male and female mice by 2,3,7,8-tetrachlorodibenzo-p-dioxin. Chemical Research in Toxicology. PMID 28238261 DOI: 10.1021/Acs.Chemrestox.6B00430 |
0.815 |
|
| 2017 |
Fader KA, Nault R, Kirby MP, Markous G, Matthews J, Zacharewski TR. Convergence of hepcidin deficiency, systemic iron overloading, heme accumulation, and REV-ERBα/β activation in aryl hydrocarbon receptor-elicited hepatotoxicity. Toxicology and Applied Pharmacology. PMID 28213091 DOI: 10.1016/J.Taap.2017.02.006 |
0.817 |
|
| 2016 |
Kovalova N, Nault R, Crawford R, Zacharewski TR, Kaminski NE. Comparative analysis of TCDD-induced AhR-mediated gene expression in human, mouse and rat primary B cells. Toxicology and Applied Pharmacology. PMID 27913140 DOI: 10.1016/J.Taap.2016.11.009 |
0.762 |
|
| 2016 |
Nault R, Fader KA, Kopec AK, Harkema JR, Zacharewski TR, Luyendyk JP. Coagulation-driven hepatic fibrosis requires protease activated receptor-1 (PAR-1) in a mouse model of TCDD-elicited steatohepatitis. Toxicological Sciences : An Official Journal of the Society of Toxicology. PMID 27613713 DOI: 10.1093/Toxsci/Kfw175 |
0.808 |
|
| 2016 |
Nault R, Fader KA, Ammendolia DA, Dornbos P, Potter D, Sharratt B, Kumagai K, Harkema JR, Lunt SY, Matthews J, Zacharewski T. Dose-dependent metabolic reprogramming and differential gene expression in TCDD-elicited hepatic fibrosis. Toxicological Sciences : An Official Journal of the Society of Toxicology. PMID 27562557 DOI: 10.1093/Toxsci/Kfw163 |
0.822 |
|
| 2016 |
Joshi N, Kopec AK, Ray JL, Cline-Fedewa H, Nawabi A, Schmitt T, Nault R, Zacharewski TR, Rockwell CE, Flick MJ, Luyendyk JP. Fibrin deposition following bile duct injury limits fibrosis through an αMβ2-dependent mechanism. Blood. PMID 26921287 DOI: 10.1182/Blood-2015-09-670703 |
0.814 |
|
| 2015 |
Nault R, Fader KA, Kirby MP, Ahmed S, Matthews J, Jones AD, Lunt SY, Zacharewski TR. Pyruvate kinase isoform switching and hepatic metabolic reprogramming by the environmental contaminant 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD). Toxicological Sciences : An Official Journal of the Society of Toxicology. PMID 26582802 DOI: 10.1093/Toxsci/Kfv245 |
0.834 |
|
| 2015 |
Saini Y, Proper SP, Dornbos P, Greenwood KK, Kopec AK, Lynn SG, Grier E, Burgoon LD, Zacharewski TR, Thomas RS, Harkema JR, LaPres JJ. Loss of Hif-2α Rescues the Hif-1α Deletion Phenotype of Neonatal Respiratory Distress In Mice. Plos One. 10: e0139270. PMID 26422241 DOI: 10.1371/Journal.Pone.0139270 |
0.738 |
|
| 2015 |
Fader KA, Nault R, Ammendolia DA, Harkema JR, Williams KJ, Crawford RB, Kaminski NE, Potter D, Sharratt B, Zacharewski TR. 2,3,7,8-Tetrachlorodibenzo-p-Dioxin (TCDD) Alters Lipid Metabolism and Depletes Immune Cell Populations in the Jejunum of C57BL/6 Mice. Toxicological Sciences : An Official Journal of the Society of Toxicology. PMID 26377647 DOI: 10.1093/Toxsci/Kfv206 |
0.846 |
|
| 2015 |
Karmaus AL, Zacharewski TR. Atrazine-Mediated Disruption of Steroidogenesis in BLTK1 Murine Leydig Cells. Toxicological Sciences : An Official Journal of the Society of Toxicology. 148: 544-54. PMID 26377646 DOI: 10.1093/Toxsci/Kfv204 |
0.308 |
|
| 2015 |
Ong CB, Kumagai K, Brooks PT, Brandenberger C, Lewandowski RP, Jackson-Humbles DN, Nault R, Zacharewski TR, Wagner JG, Harkema JR. Ozone-Induced Type 2 Immunity in Nasal Airways: Development and Lymphoid Cell Dependence in Mice. American Journal of Respiratory Cell and Molecular Biology. PMID 26203683 DOI: 10.1165/Rcmb.2015-0165Oc |
0.711 |
|
| 2015 |
Nault R, Fader KA, Zacharewski T. RNA-Seq versus oligonucleotide array assessment of dose-dependent TCDD-elicited hepatic gene expression in mice Bmc Genomics. 16: 373-373. PMID 25958198 DOI: 10.1186/S12864-015-1527-Z |
0.813 |
|
| 2015 |
Nault R, Colbry D, Brandenberger C, Harkema JR, Zacharewski TR. Development of a computational high-throughput tool for the quantitative examination of dose-dependent histological features. Toxicologic Pathology. 43: 366-75. PMID 25274660 DOI: 10.1177/0192623314544379 |
0.709 |
|
| 2013 |
Kwekel JC, Forgacs AL, Williams KJ, Zacharewski TR. o-p'-DDT-mediated uterotrophy and gene expression in immature C57BL/6 mice and Sprague-Dawley rats. Toxicology and Applied Pharmacology. 273: 532-41. PMID 24096037 DOI: 10.1016/J.Taap.2013.09.024 |
0.791 |
|
| 2013 |
Nault R, Forgacs AL, Dere E, Zacharewski TR. Comparisons of differential gene expression elicited by TCDD, PCB126, βNF, or ICZ in mouse hepatoma Hepa1c1c7 cells and C57BL/6 mouse liver. Toxicology Letters. 223: 52-9. PMID 23994337 DOI: 10.1016/J.Toxlet.2013.08.013 |
0.83 |
|
| 2013 |
Kopec AK, Boverhof DR, Nault R, Harkema JR, Tashiro C, Potter D, Sharratt B, Chittim B, Zacharewski TR. Toxicogenomic evaluation of long-term hepatic effects of TCDD in immature, ovariectomized C57BL/6 mice. Toxicological Sciences : An Official Journal of the Society of Toxicology. 135: 465-75. PMID 23864506 DOI: 10.1093/Toxsci/Kft156 |
0.835 |
|
| 2013 |
Kim S, Kiyosawa N, Burgoon LD, Chang CC, Zacharewski TR. PPARα-mediated responses in human adult liver stem cells: In vivo/in vitro and cross-species comparisons. The Journal of Steroid Biochemistry and Molecular Biology. 138: 236-47. PMID 23811191 DOI: 10.1016/J.Jsbmb.2013.06.004 |
0.801 |
|
| 2013 |
Forgacs AL, D'Souza ML, Huhtaniemi IT, Rahman NA, Zacharewski TR. Triazine herbicides and their chlorometabolites alter steroidogenesis in BLTK1 murine Leydig cells. Toxicological Sciences : An Official Journal of the Society of Toxicology. 134: 155-67. PMID 23591565 DOI: 10.1093/Toxsci/Kft096 |
0.773 |
|
| 2013 |
Forgacs AL, Dere E, Angrish MM, Zacharewski TR. Comparative analysis of temporal and dose-dependent TCDD-elicited gene expression in human, mouse, and rat primary hepatocytes. Toxicological Sciences : An Official Journal of the Society of Toxicology. 133: 54-66. PMID 23418086 DOI: 10.1093/Toxsci/Kft028 |
0.826 |
|
| 2013 |
Nault R, Kim S, Zacharewski TR. Comparison of TCDD-elicited genome-wide hepatic gene expression in Sprague-Dawley rats and C57BL/6 mice. Toxicology and Applied Pharmacology. 267: 184-91. PMID 23238561 DOI: 10.1016/J.Taap.2012.11.028 |
0.817 |
|
| 2013 |
Angrish MM, Dominici CY, Zacharewski TR. TCDD-elicited effects on liver, serum, and adipose lipid composition in C57BL/6 mice. Toxicological Sciences : An Official Journal of the Society of Toxicology. 131: 108-15. PMID 22977169 DOI: 10.1093/Toxsci/Kfs277 |
0.736 |
|
| 2012 |
Kopec AK, Thompson CM, Kim S, Forgacs AL, Zacharewski TR. Comparative toxicogenomic analysis of oral Cr(VI) exposure effects in rat and mouse small intestinal epithelia. Toxicology and Applied Pharmacology. 262: 124-38. PMID 22561333 DOI: 10.1016/J.Taap.2012.04.026 |
0.83 |
|
| 2012 |
Angrish MM, Mets BD, Jones AD, Zacharewski TR. Dietary fat is a lipid source in 2,3,7,8-tetrachlorodibenzo-ρ-dioxin (TCDD)-elicited hepatic steatosis in C57BL/6 mice. Toxicological Sciences : An Official Journal of the Society of Toxicology. 128: 377-86. PMID 22539624 DOI: 10.1093/Toxsci/Kfs155 |
0.752 |
|
| 2012 |
Forgacs AL, Ding Q, Jaremba RG, Huhtaniemi IT, Rahman NA, Zacharewski TR. BLTK1 murine Leydig cells: a novel steroidogenic model for evaluating the effects of reproductive and developmental toxicants. Toxicological Sciences : An Official Journal of the Society of Toxicology. 127: 391-402. PMID 22461451 DOI: 10.1093/Toxsci/Kfs121 |
0.741 |
|
| 2012 |
Kopec AK, Kim S, Forgacs AL, Zacharewski TR, Proctor DM, Harris MA, Haws LC, Thompson CM. Genome-wide gene expression effects in B6C3F1 mouse intestinal epithelia following 7 and 90days of exposure to hexavalent chromium in drinking water. Toxicology and Applied Pharmacology. 259: 13-26. PMID 22155349 DOI: 10.1016/J.Taap.2011.11.012 |
0.831 |
|
| 2012 |
Forgacs AL, Kent MN, Makley MK, Mets B, DelRaso N, Jahns GL, Burgoon LD, Zacharewski TR, Reo NV. Comparative metabolomic and genomic analyses of TCDD-elicited metabolic disruption in mouse and rat liver. Toxicological Sciences : An Official Journal of the Society of Toxicology. 125: 41-55. PMID 21964420 DOI: 10.1093/Toxsci/Kfr262 |
0.837 |
|
| 2011 |
Angrish MM, Jones AD, Harkema JR, Zacharewski TR. Aryl hydrocarbon receptor-mediated induction of Stearoyl-CoA desaturase 1 alters hepatic fatty acid composition in TCDD-elicited steatosis. Toxicological Sciences : An Official Journal of the Society of Toxicology. 124: 299-310. PMID 21890736 DOI: 10.1093/Toxsci/Kfr226 |
0.765 |
|
| 2011 |
Lo R, Celius T, Forgacs AL, Dere E, MacPherson L, Harper P, Zacharewski T, Matthews J. Identification of aryl hydrocarbon receptor binding targets in mouse hepatic tissue treated with 2,3,7,8-tetrachlorodibenzo-p-dioxin. Toxicology and Applied Pharmacology. 257: 38-47. PMID 21889950 DOI: 10.1016/J.Taap.2011.08.016 |
0.827 |
|
| 2011 |
Kopec AK, D'Souza ML, Mets BD, Burgoon LD, Reese SE, Archer KJ, Potter D, Tashiro C, Sharratt B, Harkema JR, Zacharewski TR. Non-additive hepatic gene expression elicited by 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) and 2,2',4,4',5,5'-hexachlorobiphenyl (PCB153) co-treatment in C57BL/6 mice. Toxicology and Applied Pharmacology. 256: 154-67. PMID 21851831 DOI: 10.1016/J.Taap.2011.08.002 |
0.822 |
|
| 2011 |
Dere E, Lo R, Celius T, Matthews J, Zacharewski TR. Integration of genome-wide computation DRE search, AhR ChIP-chip and gene expression analyses of TCDD-elicited responses in the mouse liver. Bmc Genomics. 12: 365. PMID 21762485 DOI: 10.1186/1471-2164-12-365 |
0.72 |
|
| 2011 |
Thompson CM, Proctor DM, Haws LC, Hébert CD, Grimes SD, Shertzer HG, Kopec AK, Hixon JG, Zacharewski TR, Harris MA. Investigation of the mode of action underlying the tumorigenic response induced in B6C3F1 mice exposed orally to hexavalent chromium. Toxicological Sciences : An Official Journal of the Society of Toxicology. 123: 58-70. PMID 21712504 DOI: 10.1093/Toxsci/Kfr164 |
0.678 |
|
| 2011 |
Dere E, Lee AW, Burgoon LD, Zacharewski TR. Differences in TCDD-elicited gene expression profiles in human HepG2, mouse Hepa1c1c7 and rat H4IIE hepatoma cells. Bmc Genomics. 12: 193. PMID 21496263 DOI: 10.1186/1471-2164-12-193 |
0.786 |
|
| 2011 |
Dere E, Forgacs AL, Zacharewski TR, Burgoon LD. Genome-wide computational analysis of dioxin response element location and distribution in the human, mouse, and rat genomes. Chemical Research in Toxicology. 24: 494-504. PMID 21370876 DOI: 10.1021/Tx100328R |
0.774 |
|
| 2010 |
Kopec AK, Burgoon LD, Ibrahim-Aibo D, Burg AR, Lee AW, Tashiro C, Potter D, Sharratt B, Harkema JR, Rowlands JC, Budinsky RA, Zacharewski TR. Automated dose-response analysis and comparative toxicogenomic evaluation of the hepatic effects elicited by TCDD, TCDF, and PCB126 in C57BL/6 mice. Toxicological Sciences : An Official Journal of the Society of Toxicology. 118: 286-97. PMID 20702594 DOI: 10.1093/Toxsci/Kfq236 |
0.829 |
|
| 2010 |
Fong CJ, Burgoon LD, Williams KJ, Jones AD, Forgacs AL, Zacharewski TR. Effects of tamoxifen and ethynylestradiol cotreatment on uterine gene expression in immature, ovariectomized mice. Journal of Molecular Endocrinology. 45: 161-73. PMID 20628019 DOI: 10.1677/Jme-09-0158 |
0.828 |
|
| 2010 |
Forgacs AL, Burgoon LD, Lynn SG, LaPres JJ, Zacharewski T. Effects of TCDD on the expression of nuclear encoded mitochondrial genes. Toxicology and Applied Pharmacology. 246: 58-65. PMID 20399798 DOI: 10.1016/J.Taap.2010.04.006 |
0.826 |
|
| 2010 |
Kopec AK, Burgoon LD, Ibrahim-Aibo D, Mets BD, Tashiro C, Potter D, Sharratt B, Harkema JR, Zacharewski TR. PCB153-elicited hepatic responses in the immature, ovariectomized C57BL/6 mice: comparative toxicogenomic effects of dioxin and non-dioxin-like ligands. Toxicology and Applied Pharmacology. 243: 359-71. PMID 20005886 DOI: 10.1016/J.Taap.2009.12.003 |
0.825 |
|
| 2010 |
Matthews J, Lo R, Forgacs A, Celius T, Macpherson L, Harper P, Zacharewski T. Dioxin-dependent recruitment of AHR to promoter regions in mouse liver Toxicology Letters. 196: S213. DOI: 10.1016/J.Toxlet.2010.03.718 |
0.741 |
|
| 2009 |
Kim S, Dere E, Burgoon LD, Chang CC, Zacharewski TR. Comparative analysis of AhR-mediated TCDD-elicited gene expression in human liver adult stem cells. Toxicological Sciences : An Official Journal of the Society of Toxicology. 112: 229-44. PMID 19684285 DOI: 10.1093/Toxsci/Kfp189 |
0.841 |
|
| 2009 |
Burgoon LD, Ding Q, N'jai A, Dere E, Burg AR, Rowlands JC, Budinsky RA, Stebbins KE, Zacharewski TR. Automated dose-response analysis of the relative hepatic gene expression potency of TCDF in C57BL/6 mice. Toxicological Sciences : An Official Journal of the Society of Toxicology. 112: 221-8. PMID 19675144 DOI: 10.1093/Toxsci/Kfp180 |
0.805 |
|
| 2009 |
Kwekel JC, Forgacs AL, Burgoon LD, Williams KJ, Zacharewski TR. Tamoxifen-elicited uterotrophy: cross-species and cross-ligand analysis of the gene expression program. Bmc Medical Genomics. 2: 19. PMID 19400957 DOI: 10.1186/1755-8794-2-19 |
0.837 |
|
| 2009 |
Jahns GL, Kent MN, Burgoon LD, DelRaso N, Zacharewski TR, Reo NV. Development of analytical methods for NMR spectra and application to a 13C toxicology study Metabolomics. 5: 253-262. DOI: 10.1007/S11306-008-0148-9 |
0.64 |
|
| 2008 |
Kiyosawa N, Kwekel JC, Burgoon LD, Dere E, Williams KJ, Tashiro C, Chittim B, Zacharewski TR. Species-specific regulation of PXR/CAR/ER-target genes in the mouse and rat liver elicited by o, p'-DDT. Bmc Genomics. 9: 487. PMID 18925944 DOI: 10.1186/1471-2164-9-487 |
0.786 |
|
| 2008 |
Frericks M, Burgoon LD, Zacharewski TR, Esser C. Promoter analysis of TCDD-inducible genes in a thymic epithelial cell line indicates the potential for cell-specific transcription factor crosstalk in the AhR response. Toxicology and Applied Pharmacology. 232: 268-79. PMID 18691609 DOI: 10.1016/J.Taap.2008.07.009 |
0.681 |
|
| 2008 |
Burgoon LD, Zacharewski TR. Bioinformatics: databasing and gene annotation. Methods in Molecular Biology (Clifton, N.J.). 460: 145-57. PMID 18449486 DOI: 10.1007/978-1-60327-048-9_7 |
0.662 |
|
| 2008 |
Burgoon LD, Zacharewski TR. Automated quantitative dose-response modeling and point of departure determination for large toxicogenomic and high-throughput screening data sets. Toxicological Sciences : An Official Journal of the Society of Toxicology. 104: 412-8. PMID 18441342 DOI: 10.1093/Toxsci/Kfn083 |
0.684 |
|
| 2008 |
N'Jai A, Boverhof DR, Dere E, Burgoon LD, Tan YS, Rowlands JC, Budinsky RA, Stebbins KE, Zacharewski TR. Comparative temporal toxicogenomic analysis of TCDD- and TCDF-mediated hepatic effects in immature female C57BL/6 mice. Toxicological Sciences : An Official Journal of the Society of Toxicology. 103: 285-97. PMID 18343893 DOI: 10.1093/Toxsci/Kfn053 |
0.851 |
|
| 2008 |
Kopec AK, Boverhof DR, Burgoon LD, Ibrahim-Aibo D, Harkema JR, Tashiro C, Chittim B, Zacharewski TR. Comparative toxicogenomic examination of the hepatic effects of PCB126 and TCDD in immature, ovariectomized C57BL/6 mice. Toxicological Sciences : An Official Journal of the Society of Toxicology. 102: 61-75. PMID 18042819 DOI: 10.1093/Toxsci/Kfm289 |
0.842 |
|
| 2008 |
Kiyosawa N, Kwekel JC, Burgoon LD, Williams KJ, Tashiro C, Chittim B, Zacharewski TR. o,p'-DDT elicits PXR/CAR-, not ER-, mediated responses in the immature ovariectomized rat liver. Toxicological Sciences : An Official Journal of the Society of Toxicology. 101: 350-63. PMID 17984292 DOI: 10.1093/Toxsci/Kfm275 |
0.707 |
|
| 2008 |
Boverhof DR, Burgoon LD, Williams KJ, Zacharewski TR. Inhibition of estrogen-mediated uterine gene expression responses by dioxin. Molecular Pharmacology. 73: 82-93. PMID 17942748 DOI: 10.1124/Mol.107.040451 |
0.825 |
|
| 2008 |
Kiyosawa N, Kwekel JC, Burgoon LD, Williams KJ, Tashiro C, Chittim B, Zacharewski TR. Erratum: o,p′-DDT elicits PXR/CAR-, not ER-, mediated responses in the immature ovariectomized rat liver (Toxicological Sciences (2008) vol. 101 (350-363) 10.1093/toxsci/kfm275) Toxicological Sciences. 105. DOI: 10.1093/Toxsci/Kfn143 |
0.636 |
|
| 2007 |
Fong CJ, Burgoon LD, Williams KJ, Forgacs AL, Zacharewski TR. Comparative temporal and dose-dependent morphological and transcriptional uterine effects elicited by tamoxifen and ethynylestradiol in immature, ovariectomized mice. Bmc Genomics. 8: 151. PMID 17555576 DOI: 10.1186/1471-2164-8-151 |
0.838 |
|
| 2007 |
Burgoon LD, Zacharewski TR. dbZach toxicogenomic information management system. Pharmacogenomics. 8: 287-91. PMID 17324117 DOI: 10.2217/14622416.8.3.287 |
0.564 |
|
| 2007 |
Charles GD, Gennings C, Tornesi B, Kan HL, Zacharewski TR, Bhaskar Gollapudi B, Carney EW. Analysis of the interaction of phytoestrogens and synthetic chemicals: an in vitro/in vivo comparison. Toxicology and Applied Pharmacology. 218: 280-8. PMID 17222880 DOI: 10.1016/J.Taap.2006.11.029 |
0.37 |
|
| 2007 |
Frericks M, Burgoon LD, Zacharewski T, Esser C. Transcription factor crosstalk controls the transcriptional response to AhR over activation by TCDD in thymic epithelial cells Toxicology Letters. 172: S144-S145. DOI: 10.1016/J.Toxlet.2007.05.374 |
0.623 |
|
| 2006 |
Lee K A, Burgoon LD, Lamb L, Dere E, Zacharewski TR, Hogenesch JB, LaPres JJ. Identification and characterization of genes susceptible to transcriptional cross-talk between the hypoxia and dioxin signaling cascades. Chemical Research in Toxicology. 19: 1284-93. PMID 17040097 DOI: 10.1021/Tx060068D |
0.773 |
|
| 2006 |
Boverhof DR, Burgoon LD, Tashiro C, Sharratt B, Chittim B, Harkema JR, Mendrick DL, Zacharewski TR. Comparative toxicogenomic analysis of the hepatotoxic effects of TCDD in Sprague Dawley rats and C57BL/6 mice. Toxicological Sciences : An Official Journal of the Society of Toxicology. 94: 398-416. PMID 16960034 DOI: 10.1093/Toxsci/Kfl100 |
0.836 |
|
| 2006 |
Dere E, Boverhof DR, Burgoon LD, Zacharewski TR. In vivo-in vitro toxicogenomic comparison of TCDD-elicited gene expression in Hepa1c1c7 mouse hepatoma cells and C57BL/6 hepatic tissue. Bmc Genomics. 7: 80. PMID 16611356 DOI: 10.1186/1471-2164-7-80 |
0.833 |
|
| 2006 |
Fong CJ, Burgoon LD, Zacharewski TR. Effects of culture conditions on estrogen-mediated hepatic in vitro gene expression and correlation to in vivo responses. Toxicology and Applied Pharmacology. 215: 37-50. PMID 16519913 DOI: 10.1016/J.Taap.2006.01.014 |
0.819 |
|
| 2006 |
Boverhof DR, Kwekel JC, Humes DG, Burgoon LD, Zacharewski TR. Dioxin induces an estrogen-like, estrogen receptor-dependent gene expression response in the murine uterus. Molecular Pharmacology. 69: 1599-606. PMID 16467188 DOI: 10.1124/Mol.105.019638 |
0.815 |
|
| 2006 |
Burgoon LD, Boutros PC, Dere E, Zacharewski TR. dbZach: A MIAME-compliant toxicogenomic supportive relational database. Toxicological Sciences : An Official Journal of the Society of Toxicology. 90: 558-68. PMID 16403854 DOI: 10.1093/Toxsci/Kfj097 |
0.729 |
|
| 2006 |
Boverhof DR, Zacharewski TR. Toxicogenomics in risk assessment: applications and needs. Toxicological Sciences : An Official Journal of the Society of Toxicology. 89: 352-60. PMID 16221963 DOI: 10.1093/Toxsci/Kfj018 |
0.648 |
|
| 2006 |
Lee K, Burgoon LD, Lamb L, Dere E, Zacharewski TR, Hogenesch JB, LaPres JJ. Identification and Characterization of Genes Susceptible to Transcriptional Cross-Talk between the Hypoxia and Dioxin Signaling Cascades Volume 19, Number 10, October, 2006, pp 1284−1293 Chemical Research in Toxicology. 19: 1702-1702. DOI: 10.1021/Tx600294R |
0.734 |
|
| 2005 |
Burgoon LD, Eckel-Passow JE, Gennings C, Boverhof DR, Burt JW, Fong CJ, Zacharewski TR. Protocols for the assurance of microarray data quality and process control. Nucleic Acids Research. 33: e172. PMID 16272462 DOI: 10.1093/Nar/Gni167 |
0.779 |
|
| 2005 |
Kwekel JC, Burgoon LD, Burt JW, Harkema JR, Zacharewski TR. A cross-species analysis of the rodent uterotrophic program: elucidation of conserved responses and targets of estrogen signaling. Physiological Genomics. 23: 327-42. PMID 16174780 DOI: 10.1152/Physiolgenomics.00175.2005 |
0.708 |
|
| 2005 |
Huang YW, Matthews JB, Fertuck KC, Zacharewski TR. Use of Xenopus laevis as a model for investigating in vitro and in vivo endocrine disruption in amphibians. Environmental Toxicology and Chemistry / Setac. 24: 2002-9. PMID 16152973 DOI: 10.1897/04-378R1.1 |
0.39 |
|
| 2005 |
Fong CJ, Burgoon LD, Zacharewski TR. Comparative microarray analysis of basal gene expression in mouse Hepa-1c1c7 wild-type and mutant cell lines. Toxicological Sciences : An Official Journal of the Society of Toxicology. 86: 342-53. PMID 15888666 DOI: 10.1093/Toxsci/Kfi194 |
0.762 |
|
| 2005 |
Boverhof DR, Burgoon LD, Tashiro C, Chittim B, Harkema JR, Jump DB, Zacharewski TR. Temporal and dose-dependent hepatic gene expression patterns in mice provide new insights into TCDD-Mediated hepatotoxicity. Toxicological Sciences : An Official Journal of the Society of Toxicology. 85: 1048-63. PMID 15800033 DOI: 10.1093/Toxsci/Kfi162 |
0.846 |
|
| 2005 |
Eckel JE, Gennings C, Therneau TM, Burgoon LD, Boverhof DR, Zacharewski TR. Normalization of two-channel microarray experiments: a semiparametric approach. Bioinformatics (Oxford, England). 21: 1078-83. PMID 15513988 DOI: 10.1093/Bioinformatics/Bti105 |
0.745 |
|
| 2004 |
Eckel JE, Gennings C, Chinchilli VM, Burgoon LD, Zacharewski TR. Empirical bayes gene screening tool for time-course or dose-response microarray data. Journal of Biopharmaceutical Statistics. 14: 647-70. PMID 15468757 DOI: 10.1081/Bip-200025656 |
0.623 |
|
| 2004 |
Boverhof DR, Tam E, Harney AS, Crawford RB, Kaminski NE, Zacharewski TR. 2,3,7,8-Tetrachlorodibenzo-p-dioxin induces suppressor of cytokine signaling 2 in murine B cells. Molecular Pharmacology. 66: 1662-70. PMID 15371557 DOI: 10.1124/Mol.104.002915 |
0.721 |
|
| 2004 |
Sun YV, Boverhof DR, Burgoon LD, Fielden MR, Zacharewski TR. Comparative analysis of dioxin response elements in human, mouse and rat genomic sequences. Nucleic Acids Research. 32: 4512-23. PMID 15328365 DOI: 10.1093/Nar/Gkh782 |
0.818 |
|
| 2004 |
Luyendyk JP, Mattes WB, Burgoon LD, Zacharewski TR, Maddox JF, Cosma GN, Ganey PE, Roth RA. Gene expression analysis points to hemostasis in livers of rats cotreated with lipopolysaccharide and ranitidine. Toxicological Sciences : An Official Journal of the Society of Toxicology. 80: 203-13. PMID 15084757 DOI: 10.1093/Toxsci/Kfh146 |
0.677 |
|
| 2004 |
Boverhof DR, Fertuck KC, Burgoon LD, Eckel JE, Gennings C, Zacharewski TR. Temporal- and dose-dependent hepatic gene expression changes in immature ovariectomized mice following exposure to ethynyl estradiol. Carcinogenesis. 25: 1277-91. PMID 14976129 DOI: 10.1093/Carcin/Bgh114 |
0.837 |
|
| 2004 |
Yoo BS, Boverhof DR, Shnaider D, Crawford RB, Zacharewski TR, Kaminski NE. 2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD) alters the regulation of Pax5 in lipopolysaccharide-activated B cells. Toxicological Sciences : An Official Journal of the Society of Toxicology. 77: 272-9. PMID 14600275 DOI: 10.1093/Toxsci/Kfh013 |
0.701 |
|
| 2003 |
Fertuck KC, Eckel JE, Gennings C, Zacharewski TR. Identification of temporal patterns of gene expression in the uteri of immature, ovariectomized mice following exposure to ethynylestradiol. Physiological Genomics. 15: 127-41. PMID 12915738 DOI: 10.1152/Physiolgenomics.00058.2003 |
0.495 |
|
| 2003 |
Cunningham ML, Bogdanffy MS, Zacharewski TR, Hines RN. Workshop overview: use of genomic data in risk assessment. Toxicological Sciences : An Official Journal of the Society of Toxicology. 73: 209-15. PMID 12700425 DOI: 10.1093/Toxsci/Kfg071 |
0.306 |
|
| 2003 |
Fielden MR, Samy SM, Chou KC, Zacharewski TR. Effect of human dietary exposure levels of genistein during gestation and lactation on long-term reproductive development and sperm quality in mice. Food and Chemical Toxicology : An International Journal Published For the British Industrial Biological Research Association. 41: 447-54. PMID 12615117 DOI: 10.1016/S0278-6915(02)00284-3 |
0.701 |
|
| 2003 |
Fertuck KC, Zacharewski TR. Temporal responses to estrogen in the uterus Pure and Applied Chemistry. 75: 2415-2418. DOI: 10.1351/Pac200375112415 |
0.368 |
|
| 2002 |
Matthews JB, Fertuck KC, Celius T, Huang YW, Fong CJ, Zacharewski TR. Ability of structurally diverse natural products and synthetic chemicals to induce gene expression mediated by estrogen receptors from various species. The Journal of Steroid Biochemistry and Molecular Biology. 82: 181-94. PMID 12477484 DOI: 10.1016/S0960-0760(02)00159-0 |
0.689 |
|
| 2002 |
Goodin MG, Fertuck KC, Zacharewski TR, Rosengren RJ. Estrogen receptor-mediated actions of polyphenolic catechins in vivo and in vitro Toxicological Sciences. 69: 354-361. PMID 12377984 DOI: 10.1093/toxsci/69.2.354 |
0.306 |
|
| 2002 |
Charles GD, Gennings C, Zacharewski TR, Gollapudi BB, Carney EW. An approach for assessing estrogen receptor-mediated interactions in mixtures of three chemicals: a pilot study. Toxicological Sciences : An Official Journal of the Society of Toxicology. 68: 349-60. PMID 12151631 DOI: 10.1093/Toxsci/68.2.349 |
0.337 |
|
| 2002 |
Fielden MR, Halgren RG, Fong CJ, Staub C, Johnson L, Chou K, Zacharewski TR. Gestational and lactational exposure of male mice to diethylstilbestrol causes long-term effects on the testis, sperm fertilizing ability in vitro, and testicular gene expression. Endocrinology. 143: 3044-59. PMID 12130571 DOI: 10.1210/Endo.143.8.8968 |
0.805 |
|
| 2002 |
Fielden MR, Fong CJ, Haslam SZ, Zacharewski TR. Normal mammary gland morphology in pubertal female mice following in utero and lactational exposure to genistein at levels comparable to human dietary exposure. Toxicology Letters. 133: 181-91. PMID 12119126 DOI: 10.1016/S0378-4274(02)00154-6 |
0.78 |
|
| 2002 |
Fielden MR, Halgren RG, Dere E, Zacharewski TR. GP3: GenePix post-processing program for automated analysis of raw microarray data. Bioinformatics (Oxford, England). 18: 771-3. PMID 12050078 DOI: 10.1093/Bioinformatics/18.5.771 |
0.735 |
|
| 2002 |
Fielden MR, Matthews JB, Fertuck KC, Halgren RG, Zacharewski TR. In silico approaches to mechanistic and predictive toxicology: an introduction to bioinformatics for toxicologists. Critical Reviews in Toxicology. 32: 67-112. PMID 11951993 DOI: 10.1080/20024091064183 |
0.691 |
|
| 2002 |
Charles GD, Gennings C, Zacharewski TR, Gollapudi BB, Carney EW. Assessment of interactions of diverse ternary mixtures in an estrogen receptor-alpha reporter assay. Toxicology and Applied Pharmacology. 180: 11-21. PMID 11922773 DOI: 10.1006/Taap.2001.9346 |
0.329 |
|
| 2001 |
Matthews JB, Clemons JH, Zacharewski TR. Reciprocal mutagenesis between human α(L349, M528) and rainbow trout (M317, I496) estrogen receptor residues demonstrates their importance in ligand binding and gene expression at different temperatures Molecular and Cellular Endocrinology. 183: 127-139. PMID 11604233 DOI: 10.1016/S0303-7207(01)00586-X |
0.311 |
|
| 2001 |
Fielden MR, Halgren RG, Tashiro CH, Yeo BR, Chittim B, Chou K, Zacharewski TR. Effects of gestational and lactational exposure to Aroclor 1242 on sperm quality and in vitro fertility in early adult and middle-aged mice. Reproductive Toxicology (Elmsford, N.Y.). 15: 281-92. PMID 11390173 DOI: 10.1016/S0890-6238(01)00129-0 |
0.673 |
|
| 2001 |
Fertuck KC, Kumar S, Sikka HC, Matthews JB, Zacharewski TR. Interaction of PAH-related compounds with the α and β isoforms of the estrogen receptor Toxicology Letters. 121: 167-177. PMID 11369471 DOI: 10.1016/S0378-4274(01)00344-7 |
0.32 |
|
| 2001 |
Matthews JB, Twomey K, Zacharewski TR. In vitro and in vivo interactions of bisphenol A and its metabolite, bisphenol A glucuronide, with estrogen receptors α and β Chemical Research in Toxicology. 14: 149-157. PMID 11258963 DOI: 10.1021/Tx0001833 |
0.395 |
|
| 2001 |
Fielden MR, Zacharewski TR. Challenges and limitations of gene expression profiling in mechanistic and predictive toxicology. Toxicological Sciences : An Official Journal of the Society of Toxicology. 60: 6-10. PMID 11222867 DOI: 10.1093/Toxsci/60.1.6 |
0.701 |
|
| 2001 |
Fertuck KC, Matthews JB, Zacharewski TR. Hydroxylated benzo[a]pyrene metabolites are responsible for in vitro estrogen receptor-mediated gene expression induced by benzo[a]pyrene, but do not elicit uterotrophic effects in vivo Toxicological Sciences. 59: 231-240. PMID 11158716 DOI: 10.1093/Toxsci/59.2.231 |
0.398 |
|
| 2001 |
Halgren RG, Fielden MR, Fong CJ, Zacharewski TR. Assessment of clone identity and sequence fidelity for 1189 IMAGE cDNA clones. Nucleic Acids Research. 29: 582-8. PMID 11139630 DOI: 10.1093/Nar/29.2.582 |
0.742 |
|
| 2000 |
Celius T, Matthews JB, Giesy JP, Zacharewski TR. Quantification of rainbow trout (Oncorhynchus mykiss) zona radiata and vitellogenin mRNA levels using real-time PCR after in vivo treatment with estradiol-17β or α-zearalenol Journal of Steroid Biochemistry and Molecular Biology. 75: 109-119. PMID 11226827 DOI: 10.1016/S0960-0760(00)00165-5 |
0.361 |
|
| 2000 |
Charles GD, Gennings C, Clemons J, Zacharewski TR, Gollapudi BB, Carney EW. Optimization of an estrogen receptor-alpha transcriptional activation assay for testing a diverse spectrum of chemicals. Journal of Applied Toxicology : Jat. 20: 449-54. PMID 11180266 DOI: 10.1002/1099-1263(200011/12)20:6<449::Aid-Jat712>3.0.Co;2-5 |
0.344 |
|
| 2000 |
Matthews J, Celius T, Halgren R, Zacharewski T. Differential estrogen receptor binding of estrogenic substances: a species comparison. The Journal of Steroid Biochemistry and Molecular Biology. 74: 223-234. PMID 11162928 DOI: 10.1016/S0960-0760(00)00126-6 |
0.309 |
|
| 2000 |
Charles GD, Bartels MJ, Zacharewski TR, Gollapudi BB, Freshour NL, Carney EW. Activity of benzo[a]pyrene and its hydroxylated metabolites in an estrogen receptor-alpha reporter gene assay. Toxicological Sciences : An Official Journal of the Society of Toxicology. 55: 320-6. PMID 10828263 DOI: 10.1093/Toxsci/55.2.320 |
0.329 |
|
| 2000 |
Fielden MR, Wu ZF, Sinal CJ, Jury HH, Bend JR, Hammond GL, Zacharewski TR. Estrogen receptor- and aryl hydrocarbon receptor-mediated activities of a coal-tar creosote Environmental Toxicology and Chemistry. 19: 1262-1271. DOI: 10.1002/Etc.5620190507 |
0.722 |
|
| 1998 |
Zacharewski TR, Meek MD, Clemons JH, Wu ZF, Fielden MR, Matthews JB. Examination of the in vitro and in vivo estrogenic activities of eight commercial phthalate esters. Toxicological Sciences : An Official Journal of the Society of Toxicology. 46: 282-93. PMID 10048131 DOI: 10.1006/toxs.1998.2505 |
0.686 |
|
| 1998 |
Fail PA, Hines JW, Zacharewski T, Wu ZF, Borodinsky L. Assessment of polystyrene extract for estrogenic activity in the rat uterotrophic model and an in vitro recombinant receptor reporter gene assay Drug and Chemical Toxicology. 21: 101-121. PMID 10028405 DOI: 10.3109/01480549809007405 |
0.36 |
|
| 1998 |
Gillesby BE, Zacharewski TR. Exoestrogens: Mechanisms of action and strategies for identification and assessment Environmental Toxicology and Chemistry. 17: 3-14. DOI: 10.1002/Etc.5620170102 |
0.381 |
|
| 1997 |
Fielden MR, Chen I, Chittim B, Safe SH, Zacharewski TR. Examination of the estrogenicity of 2,4,6,2',6'-pentachlorobiphenyl (PCB 104), its hydroxylated metabolite 2,4,6,2',6'-pentachloro-4-biphenylol (HO-PCB 104), and a further chlorinated derivative, 2,4,6,2',4',6'-hexachlorobiphenyl (PCB 155). Environmental Health Perspectives. 105: 1238-48. PMID 9370515 |
0.733 |
|
| 1997 |
Gillesby BE, Stanostefano M, Porter W, Safe S, Wu ZF, Zacharewski TR. Identification of a motif within the 5' regulatory region of pS2 which is responsible for AP-1 binding and TCDD-mediated suppression Biochemistry. 36: 6080-6089. PMID 9166778 DOI: 10.1021/Bi962131B |
0.508 |
|
| 1997 |
Fielden MR, Chen I, Chittim B, Safe SH, Zacharewski TR. Examination of the Estrogenicity of 2,4,6,2 prime ,6 prime -Pentachlorobiphenyl (PCB 104), Its Hydroxylated Metabolite 2,4,6,2 prime ,6 prime -Pentachloro-4-Biphenylol (HO-PCB 104), and a Further Chlorinated Derivative, 2,4,6,2 prime ,4 prime ,6 prime -Hexachlorobiphenyl (PCB 155) Environmental Health Perspectives. 105: 1238. DOI: 10.2307/3433904 |
0.671 |
|
| 1993 |
Bondy KL, Zacharewski TR. ICI 164,384: A control for investigating estrogen responsive genes Nucleic Acids Research. 21: 5277-5278. PMID 8255787 DOI: 10.1093/Nar/21.22.5277 |
0.375 |
|
| 1990 |
Bunce NJ, Landers JP, Schneider UA, Safe SH, Zacharewski TR. Chlorinated trans stilbenes: Competitive binding to the ah receptor, induction of cytochrome p-450 monooxygenase activity and partial 2, 3, 7, 8-TCDD antagonism Toxicological & Environmental Chemistry. 28: 217-229. DOI: 10.1080/02772249009357605 |
0.401 |
|
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