James C. Alwine - Publications

Affiliations: 
University of Pennsylvania, Philadelphia, PA, United States 
Area:
Molecular Biology, Microbiology Biology

29 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any innacuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2018 Walton ZE, Patel CH, Brooks RC, Yu Y, Ibrahim-Hashim A, Riddle M, Porcu A, Jiang T, Ecker BL, Tameire F, Koumenis C, Weeraratna AT, Welsh DK, Gillies R, Alwine JC, et al. Acid Suspends the Circadian Clock in Hypoxia through Inhibition of mTOR. Cell. PMID 29861175 DOI: 10.1016/j.cell.2018.05.009  0.56
2018 Ochocki JD, Khare S, Hess M, Ackerman D, Qiu B, Daisak JI, Worth AJ, Lin N, Lee P, Xie H, Li B, Wubbenhorst B, Maguire TG, Nathanson KL, Alwine JC, et al. Arginase 2 Suppresses Renal Carcinoma Progression via Biosynthetic Cofactor Pyridoxal Phosphate Depletion and Increased Polyamine Toxicity. Cell Metabolism. PMID 29754953 DOI: 10.1016/j.cmet.2018.04.009  0.64
2017 Vysochan A, Sengupta A, Weljie AM, Alwine JC, Yu Y. ACSS2-mediated acetyl-CoA synthesis from acetate is necessary for human cytomegalovirus infection. Proceedings of the National Academy of Sciences of the United States of America. PMID 28167750 DOI: 10.1073/pnas.1614268114  0.56
2014 Yu Y, Maguire TG, Alwine JC. ChREBP, a glucose-responsive transcriptional factor, enhances glucose metabolism to support biosynthesis in human cytomegalovirus-infected cells. Proceedings of the National Academy of Sciences of the United States of America. 111: 1951-6. PMID 24449882 DOI: 10.1073/pnas.1310779111  0.64
2013 Yu Y, Pierciey FJ, Maguire TG, Alwine JC. PKR-like endoplasmic reticulum kinase is necessary for lipogenic activation during HCMV infection. Plos Pathogens. 9: e1003266. PMID 23592989 DOI: 10.1371/journal.ppat.1003266  0.64
2012 Yu Y, Maguire TG, Alwine JC. Human cytomegalovirus infection induces adipocyte-like lipogenesis through activation of sterol regulatory element binding protein 1. Journal of Virology. 86: 2942-9. PMID 22258239 DOI: 10.1128/JVI.06467-11  0.64
2011 Tilton C, Clippinger AJ, Maguire T, Alwine JC. Human cytomegalovirus induces multiple means to combat reactive oxygen species. Journal of Virology. 85: 12585-93. PMID 21937645 DOI: 10.1128/JVI.05572-11  0.64
2011 Yu Y, Clippinger AJ, Pierciey FJ, Alwine JC. Viruses and metabolism: alterations of glucose and glutamine metabolism mediated by human cytomegalovirus. Advances in Virus Research. 80: 49-67. PMID 21762821 DOI: 10.1016/B978-0-12-385987-7.00003-8  0.56
2011 Clippinger AJ, Maguire TG, Alwine JC. Human cytomegalovirus infection maintains mTOR activity and its perinuclear localization during amino acid deprivation. Journal of Virology. 85: 9369-76. PMID 21734039 DOI: 10.1128/JVI.05102-11  0.64
2011 Yu Y, Clippinger AJ, Alwine JC. Viral effects on metabolism: changes in glucose and glutamine utilization during human cytomegalovirus infection. Trends in Microbiology. 19: 360-7. PMID 21570293 DOI: 10.1016/j.tim.2011.04.002  0.56
2011 Clippinger AJ, Maguire TG, Alwine JC. The changing role of mTOR kinase in the maintenance of protein synthesis during human cytomegalovirus infection. Journal of Virology. 85: 3930-9. PMID 21307192 DOI: 10.1128/JVI.01913-10  0.64
2011 Yu Y, Maguire TG, Alwine JC. Human cytomegalovirus activates glucose transporter 4 expression to increase glucose uptake during infection. Journal of Virology. 85: 1573-80. PMID 21147915 DOI: 10.1128/JVI.01967-10  0.64
2010 Buchkovich NJ, Yu Y, Pierciey FJ, Alwine JC. Human cytomegalovirus induces the endoplasmic reticulum chaperone BiP through increased transcription and activation of translation by using the BiP internal ribosome entry site. Journal of Virology. 84: 11479-86. PMID 20739513 DOI: 10.1128/JVI.01330-10  0.64
2010 Buchkovich NJ, Maguire TG, Alwine JC. Role of the endoplasmic reticulum chaperone BiP, SUN domain proteins, and dynein in altering nuclear morphology during human cytomegalovirus infection. Journal of Virology. 84: 7005-17. PMID 20484513 DOI: 10.1128/JVI.00719-10  0.64
2010 Chambers JW, Maguire TG, Alwine JC. Glutamine metabolism is essential for human cytomegalovirus infection. Journal of Virology. 84: 1867-73. PMID 19939921 DOI: 10.1128/JVI.02123-09  0.64
2009 Buchkovich NJ, Maguire TG, Paton AW, Paton JC, Alwine JC. The endoplasmic reticulum chaperone BiP/GRP78 is important in the structure and function of the human cytomegalovirus assembly compartment. Journal of Virology. 83: 11421-8. PMID 19741001 DOI: 10.1128/JVI.00762-09  0.64
2008 Buchkovich NJ, Yu Y, Zampieri CA, Alwine JC. The TORrid affairs of viruses: effects of mammalian DNA viruses on the PI3K-Akt-mTOR signalling pathway. Nature Reviews. Microbiology. 6: 266-75. PMID 18311165 DOI: 10.1038/nrmicro1855  0.64
2008 Yu Y, Alwine JC. Interaction between simian virus 40 large T antigen and insulin receptor substrate 1 is disrupted by the K1 mutation, resulting in the loss of large T antigen-mediated phosphorylation of Akt. Journal of Virology. 82: 4521-6. PMID 18305032 DOI: 10.1128/JVI.02365-07  0.56
2008 Buchkovich NJ, Maguire TG, Yu Y, Paton AW, Paton JC, Alwine JC. Human cytomegalovirus specifically controls the levels of the endoplasmic reticulum chaperone BiP/GRP78, which is required for virion assembly. Journal of Virology. 82: 31-9. PMID 17942541 DOI: 10.1128/JVI.01881-07  0.64
2007 Kudchodkar SB, Del Prete GQ, Maguire TG, Alwine JC. AMPK-mediated inhibition of mTOR kinase is circumvented during immediate-early times of human cytomegalovirus infection. Journal of Virology. 81: 3649-51. PMID 17215282 DOI: 10.1128/JVI.02079-06  0.64
2006 Kudchodkar SB, Yu Y, Maguire TG, Alwine JC. Human cytomegalovirus infection alters the substrate specificities and rapamycin sensitivities of raptor- and rictor-containing complexes. Proceedings of the National Academy of Sciences of the United States of America. 103: 14182-7. PMID 16959881 DOI: 10.1073/pnas.0605825103  0.64
2006 Yu Y, Alwine JC. 19S late mRNAs of simian virus 40 have an internal ribosome entry site upstream of the virion structural protein 3 coding sequence. Journal of Virology. 80: 6553-8. PMID 16775341 DOI: 10.1128/JVI.00517-06  0.56
2005 Isler JA, Maguire TG, Alwine JC. Production of infectious human cytomegalovirus virions is inhibited by drugs that disrupt calcium homeostasis in the endoplasmic reticulum. Journal of Virology. 79: 15388-97. PMID 16306610 DOI: 10.1128/JVI.79.24.15388-15397.2005  0.64
2005 Yu Y, Kudchodkar SB, Alwine JC. Effects of simian virus 40 large and small tumor antigens on mammalian target of rapamycin signaling: small tumor antigen mediates hypophosphorylation of eIF4E-binding protein 1 late in infection. Journal of Virology. 79: 6882-9. PMID 15890927 DOI: 10.1128/JVI.79.11.6882-6889.2005  0.64
2005 Barrasa MI, Harel NY, Alwine JC. The phosphorylation status of the serine-rich region of the human cytomegalovirus 86-kilodalton major immediate-early protein IE2/IEP86 affects temporal viral gene expression. Journal of Virology. 79: 1428-37. PMID 15650169 DOI: 10.1128/JVI.79.3.1428-1437.2005  0.64
2004 Kudchodkar SB, Yu Y, Maguire TG, Alwine JC. Human cytomegalovirus infection induces rapamycin-insensitive phosphorylation of downstream effectors of mTOR kinase. Journal of Virology. 78: 11030-9. PMID 15452223 DOI: 10.1128/JVI.78.20.11030-11039.2004  0.64
2003 Barrasa MI, Harel N, Yu Y, Alwine JC. Strain variations in single amino acids of the 86-kilodalton human cytomegalovirus major immediate-early protein (IE2) affect its functional and biochemical properties: implications of dynamic protein conformation. Journal of Virology. 77: 4760-72. PMID 12663783 DOI: 10.1128/JVI.77.8.4760-4772.2003  0.64
2002 Yu Y, Alwine JC. Human cytomegalovirus major immediate-early proteins and simian virus 40 large T antigen can inhibit apoptosis through activation of the phosphatidylinositide 3'-OH kinase pathway and the cellular kinase Akt. Journal of Virology. 76: 3731-8. PMID 11907212  0.56
2002 Heider JA, Yu Y, Shenk T, Alwine JC. Characterization of a human cytomegalovirus with phosphorylation site mutations in the immediate-early 2 protein. Journal of Virology. 76: 928-32. PMID 11752183 DOI: 10.1128/JVI.76.2.928-932.2002  0.64
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