Nigel Killeen - Publications

Affiliations: 
University of California, San Francisco, San Francisco, CA 
Area:
Microbiology Biology

78 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2019 Herzig E, Kim KC, Packard TA, Vardi N, Schwarzer R, Gramatica A, Deeks SG, Williams SR, Landgraf K, Killeen N, Martin DW, Weinberger LS, Greene WC. Attacking Latent HIV with convertibleCAR-T Cells, a Highly Adaptable Killing Platform. Cell. 179: 880-894.e10. PMID 31668804 DOI: 10.1016/J.Cell.2019.10.002  0.371
2018 Vanheerswynghels M, Toussaint W, Schuijs M, Vanhoutte L, Killeen N, Hammad H, Lambrecht BN. The Generation and Use of Allergen-Specific TCR Transgenic Animals. Methods in Molecular Biology (Clifton, N.J.). 1799: 183-210. PMID 29956153 DOI: 10.1007/978-1-4939-7896-0_15  0.482
2013 Plantinga M, Guilliams M, Vanheerswynghels M, Deswarte K, Branco-Madeira F, Toussaint W, Vanhoutte L, Neyt K, Killeen N, Malissen B, Hammad H, Lambrecht BN. Conventional and monocyte-derived CD11b(+) dendritic cells initiate and maintain T helper 2 cell-mediated immunity to house dust mite allergen. Immunity. 38: 322-35. PMID 23352232 DOI: 10.1016/J.Immuni.2012.10.016  0.466
2012 Gough MJ, Killeen N, Weinberg AD. Targeting macrophages in the tumour environment to enhance the efficacy of αOX40 therapy. Immunology. 136: 437-47. PMID 22578109 DOI: 10.1111/J.1365-2567.2012.03600.X  0.311
2011 Menzel U, Kosteas T, Tolaini M, Killeen N, Roderick K, Kioussis D. Modulation of the murine CD8 gene complex following the targeted integration of human CD2-locus control region sequences. Journal of Immunology (Baltimore, Md. : 1950). 187: 3712-20. PMID 21880987 DOI: 10.4049/Jimmunol.1100709  0.548
2010 Au-Yeung BB, Levin SE, Zhang C, Hsu LY, Cheng DA, Killeen N, Shokat KM, Weiss A. A genetically selective inhibitor demonstrates a function for the kinase Zap70 in regulatory T cells independent of its catalytic activity. Nature Immunology. 11: 1085-92. PMID 21037577 DOI: 10.1038/Ni.1955  0.445
2010 Rolf J, Bell SE, Kovesdi D, Janas ML, Soond DR, Webb LM, Santinelli S, Saunders T, Hebeis B, Killeen N, Okkenhaug K, Turner M. Phosphoinositide 3-kinase activity in T cells regulates the magnitude of the germinal center reaction. Journal of Immunology (Baltimore, Md. : 1950). 185: 4042-52. PMID 20826752 DOI: 10.4049/Jimmunol.1001730  0.468
2010 Lee K, Gudapati P, Dragovic S, Spencer C, Joyce S, Killeen N, Magnuson MA, Boothby M. Mammalian target of rapamycin protein complex 2 regulates differentiation of Th1 and Th2 cell subsets via distinct signaling pathways. Immunity. 32: 743-53. PMID 20620941 DOI: 10.1016/J.Immuni.2010.06.002  0.414
2010 Klinger M, Chmura SA, Killeen N. Reporter alleles that inform on differences in Cre recombinase expression. Journal of Immunology (Baltimore, Md. : 1950). 184: 6170-6. PMID 20427774 DOI: 10.4049/Jimmunol.1000089  0.308
2010 Wong JC, Zhang Y, Lieuw KH, Tran MT, Forgo E, Weinfurtner K, Alzamora P, Kogan SC, Akagi K, Wolff L, Le Beau MM, Killeen N, Shannon K. Use of chromosome engineering to model a segmental deletion of chromosome band 7q22 found in myeloid malignancies. Blood. 115: 4524-32. PMID 20233966 DOI: 10.1182/Blood-2009-07-232504  0.358
2009 Marques R, Williams A, Eksmond U, Wullaert A, Killeen N, Pasparakis M, Kioussis D, Kassiotis G. Generalized immune activation as a direct result of activated CD4+ T cell killing. Journal of Biology. 8: 93. PMID 19943952 DOI: 10.1186/jbiol194  0.407
2009 Kim JK, Klinger M, Benjamin J, Xiao Y, Erle DJ, Littman DR, Killeen N. Impact of the TCR signal on regulatory T cell homeostasis, function, and trafficking. Plos One. 4: e6580. PMID 19668367 DOI: 10.1371/Journal.Pone.0006580  0.564
2009 Klinger M, Kim JK, Chmura SA, Barczak A, Erle DJ, Killeen N. Thymic OX40 expression discriminates cells undergoing strong responses to selection ligands. Journal of Immunology (Baltimore, Md. : 1950). 182: 4581-9. PMID 19342632 DOI: 10.4049/Jimmunol.0900010  0.529
2009 Zhang Y, Wong J, Klinger M, Tran MT, Shannon KM, Killeen N. MLL5 contributes to hematopoietic stem cell fitness and homeostasis. Blood. 113: 1455-63. PMID 18818388 DOI: 10.1182/Blood-2008-05-159905  0.359
2007 Yin X, Ladi E, Chan SW, Li O, Killeen N, Kappes DJ, Robey EA. CCR7 expression in developing thymocytes is linked to the CD4 versus CD8 lineage decision. Journal of Immunology (Baltimore, Md. : 1950). 179: 7358-64. PMID 18025179 DOI: 10.4049/Jimmunol.179.11.7358  0.593
2007 Haynes NM, Allen CD, Lesley R, Ansel KM, Killeen N, Cyster JG. Role of CXCR5 and CCR7 in follicular Th cell positioning and appearance of a programmed cell death gene-1high germinal center-associated subpopulation. Journal of Immunology (Baltimore, Md. : 1950). 179: 5099-108. PMID 17911595 DOI: 10.4049/Jimmunol.179.8.5099  0.467
2007 Vu MD, Xiao X, Gao W, Degauque N, Chen M, Kroemer A, Killeen N, Ishii N, Li XC. OX40 costimulation turns off Foxp3+ Tregs. Blood. 110: 2501-10. PMID 17575071 DOI: 10.1182/Blood-2007-01-070748  0.528
2007 Chang JT, Palanivel VR, Kinjyo I, Schambach F, Intlekofer AM, Banerjee A, Longworth SA, Vinup KE, Mrass P, Oliaro J, Killeen N, Orange JS, Russell SM, Weninger W, Reiner SL. Asymmetric T lymphocyte division in the initiation of adaptive immune responses. Science (New York, N.Y.). 315: 1687-91. PMID 17332376 DOI: 10.1126/Science.1139393  0.377
2007 Wong JC, Zhang Y, Tran MT, Lieuw KH, Wolff L, Killeen N, Shannon K. Use of Chromosome Engineering To Model a Leukemia-Associated 7q22 Deletion in the Mouse. Blood. 110: 2654-2654. DOI: 10.1182/Blood.V110.11.2654.2654  0.319
2005 Aurora AB, Baluk P, Zhang D, Sidhu SS, Dolganov GM, Basbaum C, McDonald DM, Killeen N. Immune complex-dependent remodeling of the airway vasculature in response to a chronic bacterial infection. Journal of Immunology (Baltimore, Md. : 1950). 175: 6319-26. PMID 16272283 DOI: 10.4049/Jimmunol.175.10.6319  0.688
2005 Mohrs K, Wakil AE, Killeen N, Locksley RM, Mohrs M. A two-step process for cytokine production revealed by IL-4 dual-reporter mice. Immunity. 23: 419-29. PMID 16226507 DOI: 10.1016/J.Immuni.2005.09.006  0.321
2005 Zhang DJ, Wang Q, Wei J, Baimukanova G, Buchholz F, Stewart AF, Mao X, Killeen N. Selective expression of the Cre recombinase in late-stage thymocytes using the distal promoter of the Lck gene. Journal of Immunology (Baltimore, Md. : 1950). 174: 6725-31. PMID 15905512 DOI: 10.4049/Jimmunol.174.11.6725  0.437
2005 Valzasina B, Guiducci C, Dislich H, Killeen N, Weinberg AD, Colombo MP. Triggering of OX40 (CD134) on CD4(+)CD25+ T cells blocks their inhibitory activity: a novel regulatory role for OX40 and its comparison with GITR. Blood. 105: 2845-51. PMID 15591118 DOI: 10.1182/Blood-2004-07-2959  0.544
2004 Zhu J, Min B, Hu-Li J, Watson CJ, Grinberg A, Wang Q, Killeen N, Urban JF, Guo L, Paul WE. Conditional deletion of Gata3 shows its essential function in T(H)1-T(H)2 responses. Nature Immunology. 5: 1157-65. PMID 15475959 DOI: 10.1038/Ni1128  0.381
2004 Kwan J, Killeen N. CCR7 directs the migration of thymocytes into the thymic medulla. Journal of Immunology (Baltimore, Md. : 1950). 172: 3999-4007. PMID 15034011 DOI: 10.4049/Jimmunol.172.7.3999  0.662
2004 Takeda I, Ine S, Killeen N, Ndhlovu LC, Murata K, Satomi S, Sugamura K, Ishii N. Distinct roles for the OX40-OX40 ligand interaction in regulatory and nonregulatory T cells. Journal of Immunology (Baltimore, Md. : 1950). 172: 3580-9. PMID 15004159 DOI: 10.4049/Jimmunol.172.6.3580  0.618
2004 Pawlikowska L, Groen A, Eppens EF, Kunne C, Ottenhoff R, Looije N, Knisely AS, Killeen NP, Bull LN, Elferink RP, Freimer NB. A mouse genetic model for familial cholestasis caused by ATP8B1 mutations reveals perturbed bile salt homeostasis but no impairment in bile secretion. Human Molecular Genetics. 13: 881-92. PMID 14976163 DOI: 10.1093/Hmg/Ddh100  0.545
2003 Carboni S, Aboul-Enein F, Waltzinger C, Killeen N, Lassmann H, Peña-Rossi C. CD134 plays a crucial role in the pathogenesis of EAE and is upregulated in the CNS of patients with multiple sclerosis. Journal of Neuroimmunology. 145: 1-11. PMID 14644025 DOI: 10.1016/J.Jneuroim.2003.07.001  0.55
2003 Blazar BR, Sharpe AH, Chen AI, Panoskaltsis-Mortari A, Lees C, Akiba H, Yagita H, Killeen N, Taylor PA. Ligation of OX40 (CD134) regulates graft-versus-host disease (GVHD) and graft rejection in allogeneic bone marrow transplant recipients. Blood. 101: 3741-8. PMID 12521997 DOI: 10.1182/Blood-2002-10-3048  0.57
2002 Ohlrogge W, Haag F, Löhler J, Seman M, Littman DR, Killeen N, Koch-Nolte F. Generation and characterization of ecto-ADP-ribosyltransferase ART2.1/ART2.2-deficient mice. Molecular and Cellular Biology. 22: 7535-42. PMID 12370300 DOI: 10.1128/Mcb.22.21.7535-7542.2002  0.479
2002 Killeen N. A new spin on an unusual tail. Nature Immunology. 3: 419-21. PMID 11976716 DOI: 10.1038/Ni0502-419  0.36
2001 Wang Q, Strong J, Killeen N. Homeostatic competition among T cells revealed by conditional inactivation of the mouse Cd4 gene. The Journal of Experimental Medicine. 194: 1721-30. PMID 11748274 DOI: 10.1084/Jem.194.12.1721  0.729
2001 Zou YR, Sunshine MJ, Taniuchi I, Hatam F, Killeen N, Littman DR. Epigenetic silencing of CD4 in T cells committed to the cytotoxic lineage Nature Genetics. 29: 332-336. PMID 11687799 DOI: 10.1038/Ng750  0.541
2001 Wang Q, Malherbe L, Zhang D, Zingler K, Glaichenhaus N, Killeen N. CD4 promotes breadth in the TCR repertoire Journal of Immunology. 167: 4311-4320. PMID 11591754 DOI: 10.4049/Jimmunol.167.8.4311  0.575
2001 Sosinowski T, Killeen N, Weiss A. The Src-like adaptor protein downregulates the T cell receptor on CD4+CD8+ thymocytes and regulates positive selection. Immunity. 15: 457-66. PMID 11567635 DOI: 10.1016/S1074-7613(01)00195-9  0.565
2001 Rogers PR, Song J, Gramaglia I, Killeen N, Croft M. OX40 promotes Bcl-xL and Bcl-2 expression and is essential for long-term survival of CD4 T cells Immunity. 15: 445-455. PMID 11567634 DOI: 10.1016/S1074-7613(01)00191-1  0.577
2001 Strong J, Wang Q, Killeen N. Impaired survival of T helper cells in the absence of CD4. Proceedings of the National Academy of Sciences of the United States of America. 98: 2566-71. PMID 11226279 DOI: 10.1073/Pnas.051329698  0.718
2001 Dennehy KM, Ferris WF, Veenstra H, Zuckerman LA, Killeen N, Beyers AD. Determination of the tyrosine phosphorylation sites in the T cell transmembrane glycoprotein CD5. International Immunology. 13: 149-56. PMID 11157848 DOI: 10.1093/Intimm/13.2.149  0.505
2000 Majeti R, Xu Z, Parslow TG, Olson JL, Daikh DI, Killeen N, Weiss A. An inactivating point mutation in the inhibitory wedge of CD45 causes lymphoproliferation and autoimmunity. Cell. 103: 1059-70. PMID 11163182 DOI: 10.1016/S0092-8674(00)00209-9  0.506
2000 Gramaglia I, Jember A, Pippig SD, Weinberg AD, Killeen N, Croft M. The OX40 costimulatory receptor determines the development of CD4 memory by regulating primary clonal expansion. Journal of Immunology (Baltimore, Md. : 1950). 165: 3043-50. PMID 10975814 DOI: 10.4049/Jimmunol.165.6.3043  0.549
1999 Pippig SD, Peña-Rossi C, Long J, Godfrey WR, Fowell DJ, Reiner SL, Birkeland ML, Locksley RM, Barclay AN, Killeen N. Robust B cell immunity but impaired T cell proliferation in the absence of CD134 (OX40). Journal of Immunology (Baltimore, Md. : 1950). 163: 6520-9. PMID 10586044  0.559
1999 Peña-Rossi C, Zuckerman LA, Strong J, Kwan J, Ferris W, Chan S, Tarakhovsky A, Beyers AD, Killeen N. Negative regulation of CD4 lineage development and responses by CD5. Journal of Immunology (Baltimore, Md. : 1950). 163: 6494-501. PMID 10586041  0.741
1999 Koch-Nolte F, Duffy T, Nissen M, Kahl S, Killeen N, Ablamunits V, Haag F, Leiter EH. A new monoclonal antibody detects a developmentally regulated mouse ecto-ADP-ribosyltransferase on T cells: Subset distribution, inbred strain variation, and modulation upon T cell activation Journal of Immunology. 163: 6014-6022. PMID 10570289  0.472
1999 Shelbourne PF, Killeen N, Hevner RF, Johnston HM, Tecott L, Lewandoski M, Ennis M, Ramirez L, Li Z, Iannicola C, Littman DR, Myers RM. A Huntington's disease CAG expansion at the murine Hdh locus is unstable and associated with behavioural abnormalities in mice. Human Molecular Genetics. 8: 763-74. PMID 10196365 DOI: 10.1093/Hmg/8.5.763  0.303
1998 Kadlecek TA, Van Oers NSC, Lefrancois L, Olson S, Finlay D, Chu DH, Connolly K, Killeen N, Weiss A. Differential requirements for ZAP-70 in TCR signaling and T cell development Journal of Immunology. 161: 4688-4694. PMID 9794398  0.43
1998 Killeen N, Irving BA, Pippig S, Zingler K. Signaling checkpoints during the development of T lymphocytes. Current Opinion in Immunology. 10: 360-7. PMID 9638374 DOI: 10.1016/S0952-7915(98)80176-3  0.46
1998 Chesnutt MS, Finck BK, Killeen N, Connolly MK, Goodman H, Wofsy D. Enhanced lymphoproliferation and diminished autoimmunity in CD4- deficient MRL/lpr mice Clinical Immunology and Immunopathology. 87: 23-32. PMID 9576007 DOI: 10.1006/clin.1997.4492  0.492
1998 Irving BA, Alt FW, Killeen N. Thymocyte development in the absence of pre-T cell receptor extracellular immunoglobulin domains. Science (New York, N.Y.). 280: 905-8. PMID 9572735 DOI: 10.1126/Science.280.5365.905  0.439
1998 Reiner SL, Fowell DJ, Moskowitz NH, Swier K, Brown DR, Brown CR, Turck CW, Scott PA, Killeen N, Locksley RM. Control of Leishmania major by a monoclonal alpha beta T cell repertoire. Journal of Immunology (Baltimore, Md. : 1950). 160: 884-9. PMID 9551925  0.32
1997 Killeen N. T-cell regulation: Thy-1 - Hiding in full view Current Biology. 7. PMID 9382830 DOI: 10.1016/S0960-9822(06)00402-7  0.428
1997 Liao XC, Fournier S, Killeen N, Weiss A, Allison JP, Littman DR. Itk negatively regulates induction of T cell proliferation by CD28 costimulation Journal of Experimental Medicine. 186: 221-228. PMID 9221751 DOI: 10.1084/Jem.186.2.221  0.605
1997 Brown DR, Moskowitz NH, Killeen N, Reiner SL. A role for CD4 in peripheral T cell differentiation Journal of Experimental Medicine. 186: 101-107. PMID 9207001 DOI: 10.1084/Jem.186.1.101  0.612
1997 Fowell DJ, Magram J, Turck CW, Killeen N, Locksley RM. Impaired Th2 subset development in the absence of CD4 Immunity. 6: 559-569. PMID 9175834 DOI: 10.1016/S1074-7613(00)80344-1  0.611
1997 Teh S, Killeen N, Tarakhovsky A, Littman DR, Teh H. CD2 Regulates the Positive Selection and Function of Antigen-Specific CD4−CD8+ T Cells Blood. 89: 1308-1318. DOI: 10.1182/Blood.V89.4.1308  0.601
1996 Weiss CD, Barnett SW, Cacalano N, Killeen N, Littman DR, White JM. Studies of HIV-1 envelope glycoprotein-mediated fusion using a simple fluorescence assay Aids. 10: 241-246. PMID 8882662 DOI: 10.1097/00002030-199603000-00001  0.506
1996 Van Oers NSC, Killeen N, Weiss A. Lck regulates the tyrosine phosphorylation of the T cell receptor subunits and ZAP-70 in murine thymocytes Journal of Experimental Medicine. 183: 1053-1062. PMID 8642247 DOI: 10.1084/Jem.183.3.1053  0.435
1996 Matechak EO, Killeen N, Hedrick SM, Fowlkes BJ. MHC class II-specific T cells can develop in the CD8 lineage when CD4 is absent Immunity. 4: 337-347. PMID 8612128 DOI: 10.1016/S1074-7613(00)80247-2  0.562
1996 Killeen N, Littman DR. The regulation and function of the CD4 coreceptor during T lymphocyte development Current Topics in Microbiology and Immunology. 205: 88-106. PMID 8575199 DOI: 10.1007/978-3-642-79798-9_5  0.571
1996 Teh HS, Killeen N, Teh SJ. Cd2 regulates the positive selection and function of antigen-specific cd4-cd8+ t cells Faseb Journal. 10.  0.524
1996 Teh HS, Killeen N, Teh SJ. Cd2 regulates the positive selection and function of antigen-specific cd4-cd8+ t cells Faseb Journal. 10.  0.524
1995 Tarakhovsky A, Kanner SB, Hombach J, Ledbetter JA, Müller W, Killeen N, Rajewsky K. A role for CD5 in TCR-mediated signal transduction and thymocyte selection. Science (New York, N.Y.). 269: 535-7. PMID 7542801 DOI: 10.1126/Science.7542801  0.622
1995 Killeen N, Littman DR. The function of the CD4 coreceptor in the development of t cells International Reviews of Immunology. 13: 15-27. PMID 7494106 DOI: 10.3109/08830189509061735  0.606
1994 Sawada S, Scarborough JD, Killeen N, Littman DR. A lineage-specific transcriptional silencer regulates CD4 gene expression during T lymphocyte development Cell. 77: 917-929. PMID 8004678 DOI: 10.1016/0092-8674(94)90140-6  0.536
1994 Rajan TV, Nelson FK, Killeen N, Shultz LD, Yates JA, Bailis JM, Littman DR, Greiner DL. CD4+ T-Lymphocytes Are Not Required for Murine Resistance to the Human Filarial Parasite, Brugia malayi Experimental Parasitology. 78: 352-360. PMID 7911434 DOI: 10.1006/Expr.1994.1038  0.58
1994 Bendelac A, Killeen N, Littman DR, Schwartz RH. A subset of CD4+ thymocytes selected by MHC class I molecules Science. 263: 1774-1778. PMID 7907820 DOI: 10.1126/Science.7907820  0.532
1994 Littman DR, Davis CB, Killeen N, Xu H. Signal transduction during T cell development Advances in Experimental Medicine and Biology. 365: 63. PMID 7887314 DOI: 10.1007/978-1-4899-0987-9_7  0.56
1994 van Oers NSC, Killeen N, Welss A. ZAP-70 is constitutively associated with tyrosine-phosphorylated TCR ζ in murine thymocytes and lymph node T cells Immunity. 1: 675-685. PMID 7600293 DOI: 10.1016/1074-7613(94)90038-8  0.383
1993 Killeen N, Sawada S, Littman DR. Regulated expression of human CD4 rescues helper T cell development in mice lacking expression of endogenous CD4 Embo Journal. 12: 1547-1553. PMID 8467804  0.534
1993 Locksley RM, Reiner SL, Hatam F, Littman DR, Killeen N. Helper T cells without CD4: Control of leishmaniasis in CD4-deficient mice Science. 261: 1448-1451. PMID 8367726 DOI: 10.1126/Science.8367726  0.606
1993 Killeen N, Littman DR. Helper T-cell development in the absence of CD4-p56Ick association Nature. 364: 729-732. PMID 8355789 DOI: 10.1038/364729A0  0.589
1993 Davis CB, Killeen N, Crooks MEC, Raulet D, Littman DR. Evidence for a stochastic mechanism in the differentiation of mature subsets of T lymphocytes Cell. 73: 237-247. PMID 8097431 DOI: 10.1016/0092-8674(93)90226-G  0.551
1993 Killeen N, Davis CB, Chu K, Crooks ME, Sawada S, Scarborough JD, Boyd KA, Stuart SG, Xu H, Littman DR. CD4 function in thymocyte differentiation and T cell activation Philosophical Transactions of the Royal Society of London. Series B: Biological Sciences. 342: 25-34. PMID 7904343 DOI: 10.1098/Rstb.1993.0131  0.592
1993 Evans CF, Rall GF, Killeen N, Littman D, Oldstone MB. CD2-deficient mice generate virus-specific cytotoxic T lymphocytes upon infection with lymphocytic choriomeningitis virus. Journal of Immunology (Baltimore, Md. : 1950). 151: 6259-64. PMID 7902375  0.44
1993 Killeen N, Sawada S, Littman D. Regulated expression of human CD4 rescues helper T cell development in mice lacking expression of endogenous CD4. The Embo Journal. 12: 1547-1553. DOI: 10.1002/J.1460-2075.1993.Tb05798.X  0.602
1992 Killeen N, Moriarty A, Teh HS, Littman DR. Requirement for CD8-major histocompatibility complex class I interaction in positive and negative selection of developing T cells Journal of Experimental Medicine. 176: 89-97. PMID 1613468 DOI: 10.1084/Jem.176.1.89  0.56
1992 Killeen N, Stuart SG, Littman DR. Development and function of T cells in mice with a disrupted CD2 gene Embo Journal. 11: 4329-4336. PMID 1358605  0.558
1992 Killeen N, Stuart S, Littman D. Development and function of T cells in mice with a disrupted CD2 gene. The Embo Journal. 11: 4329-4336. DOI: 10.1002/J.1460-2075.1992.Tb05532.X  0.623
1988 Killeen N, Moessner R, Arvieux J, Willis A, Williams AF. The MRC OX-45 antigen of rat leukocytes and endothelium is in a subset of the immunoglobulin superfamily with CD2, LFA-3 and carcinoembryonic antigens Embo Journal. 7: 3087-3091. PMID 3181129 DOI: 10.1002/J.1460-2075.1988.Tb03174.X  0.361
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