| Year |
Citation |
Score |
| 2017 |
Coffey GP, Feng J, Betz A, Pandey A, Birrell M, Leeds JM, Der K, Kadri S, Lu P, Segal J, Wang L, Michelson G, Curnutte JT, Conley PB. Cerdulatinib Pharmacodynamics and Relationships to Tumor Response Following Oral Dosing in Patients with Relapsed/Refractory B Cell Malignancies: Results from a Phase I Dose Escalation Study Blood. 130: 2782-2782. DOI: 10.1182/Blood.V130.Suppl_1.2782.2782 |
0.314 |
|
| 2016 |
Coffey G, Rani A, Betz A, Pak Y, Haberstock-Debic H, Pandey A, Hollenbach S, Gretler DD, Mant T, Jurcevic S, Sinha U. PRT062607 Achieves Complete Inhibition of the Spleen Tyrosine Kinase at Tolerated Exposures Following Oral Dosing in Healthy Volunteers. Journal of Clinical Pharmacology. PMID 27406873 DOI: 10.1002/Jcph.794 |
0.356 |
|
| 2014 |
Coffey G, Betz A, DeGuzman F, Pak Y, Inagaki M, Baker DC, Hollenbach SJ, Pandey A, Sinha U. The novel kinase inhibitor PRT062070 (Cerdulatinib) demonstrates efficacy in models of autoimmunity and B-cell cancer. The Journal of Pharmacology and Experimental Therapeutics. 351: 538-48. PMID 25253883 DOI: 10.1124/Jpet.114.218164 |
0.361 |
|
| 2013 |
Coffey G, Betz A, Graf J, Stephens G, Hua Lin P, Imboden J, Sinha U. Methotrexate and a spleen tyrosine kinase inhibitor cooperate to inhibit responses to peripheral blood B cells in rheumatoid arthritis. Pharmacology Research & Perspectives. 1: e00016. PMID 25505569 DOI: 10.1002/Prp2.16 |
0.365 |
|
| 2013 |
Spurgeon SE, Coffey G, Fletcher LB, Burke R, Tyner JW, Druker BJ, Betz A, DeGuzman F, Pak Y, Baker D, Pandey A, Hollenbach SJ, Sinha U, Loriaux MM. The selective SYK inhibitor P505-15 (PRT062607) inhibits B cell signaling and function in vitro and in vivo and augments the activity of fludarabine in chronic lymphocytic leukemia. The Journal of Pharmacology and Experimental Therapeutics. 344: 378-87. PMID 23220742 DOI: 10.1124/Jpet.112.200832 |
0.375 |
|
| 2012 |
Coffey G, DeGuzman F, Inagaki M, Pak Y, Delaney SM, Ives D, Betz A, Jia ZJ, Pandey A, Baker D, Hollenbach SJ, Phillips DR, Sinha U. Specific inhibition of spleen tyrosine kinase suppresses leukocyte immune function and inflammation in animal models of rheumatoid arthritis. The Journal of Pharmacology and Experimental Therapeutics. 340: 350-9. PMID 22040680 DOI: 10.1124/Jpet.111.188441 |
0.386 |
|
| 2010 |
Coffey G, Francis D, Inagaki M, Pak Y, Delaney S, Betz A, Jia ZJ, Xu Q, Bauer S, Song Y, Pandey A, Baker D, Hollenbach S, Phillips DR, Sinha U. Specific Inhibition of Syk Suppresses Leukocyte Immune Function and Alleviates Inflammation In Rodent Models of Rheumatoid Arthritis Blood. 116: 1727-1727. DOI: 10.1182/Blood.V116.21.1727.1727 |
0.378 |
|
| 2002 |
Edwards ST, Betz A, James HL, Thompson E, Yonkovich SJ, Sinha U. Differences between human and rabbit coagulation factor X-implications for in vivo models of thrombosis. Thrombosis Research. 106: 71-9. PMID 12165292 DOI: 10.1016/S0049-3848(02)00076-2 |
0.37 |
|
| 2001 |
Lin P, Sinha U, Betz A. Antithrombin binding of low molecular weight heparins and inhibition of factor Xa. Biochimica Et Biophysica Acta. 1526: 105-13. PMID 11287128 DOI: 10.1016/S0304-4165(01)00117-9 |
0.357 |
|
| 1999 |
Betz A, Wong PW, Sinha U. Inhibition of factor Xa by a peptidyl-alpha-ketothiazole involves two steps. Evidence for a stabilizing conformational change. Biochemistry. 38: 14582-91. PMID 10545181 DOI: 10.1021/Bi990958A |
0.445 |
|
| 1998 |
Betz A, Krishnaswamy S. Regions remote from the site of cleavage determine macromolecular substrate recognition by the prothrombinase complex Journal of Biological Chemistry. 273: 10709-10718. PMID 9553135 DOI: 10.1074/Jbc.273.17.10709 |
0.525 |
|
| 1997 |
Krishnaswamy S, Betz A. Exosites determine macromolecular substrate recognition by prothrombinase Biochemistry. 36: 12080-12086. PMID 9315846 DOI: 10.1021/Bi970979+ |
0.539 |
|
| 1997 |
Betz A, Vlasuk GP, Bergum PW, Krishnaswamy S. Selective inhibition of the prothrombinase complex: Factor Va alters macromolecular recognition of a tick anticoagulant peptide mutant by factor Xa Biochemistry. 36: 181-191. PMID 8993332 DOI: 10.1021/Bi962060G |
0.498 |
|
| 1992 |
Betz A, Hofsteenge J, Stone SR. pH dependence of the interaction of hirudin with thrombin. Biochemistry. 31: 1168-72. PMID 1734964 DOI: 10.1021/Bi00119A028 |
0.319 |
|
| 1992 |
Betz A, Hofsteenge J, Stone SR. Interaction of the N-terminal region of hirudin with the active-site cleft of thrombin. Biochemistry. 31: 4557-62. PMID 1581311 DOI: 10.1021/Bi00134A004 |
0.406 |
|
| 1991 |
Betz A, Hofsteenge J, Stone SR. Role of interactions involving C-terminal nonpolar residues of hirudin in the formation of the thrombin-hirudin complex. Biochemistry. 30: 9848-53. PMID 1911777 DOI: 10.1021/Bi00105A006 |
0.349 |
|
| 1991 |
Stone SR, Betz A, Hofsteenge J. Mechanistic studies on thrombin catalysis. Biochemistry. 30: 9841-8. PMID 1911776 DOI: 10.1021/Bi00105A005 |
0.352 |
|
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