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George B. Spiegelman - Publications

Affiliations: 
University of British Columbia, Vancouver, Vancouver, BC, Canada 
Area:
Microbiology Biology
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80 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2013 Burian J, Yim G, Hsing M, Axerio-Cilies P, Cherkasov A, Spiegelman GB, Thompson CJ. The mycobacterial antibiotic resistance determinant WhiB7 acts as a transcriptional activator by binding the primary sigma factor SigA (RpoV). Nucleic Acids Research. 41: 10062-76. PMID 23990327 DOI: 10.1093/Nar/Gkt751  0.387
2013 Yim G, Spiegelman GB, Davies JE. Separate mechanisms are involved in rifampicin upmodulated and downmodulated gene expression in Salmonella Typhimurium. Research in Microbiology. 164: 416-24. PMID 23419780 DOI: 10.1016/J.Resmic.2013.02.003  0.375
2012 Leung MM, Brimacombe CA, Spiegelman GB, Beatty JT. The GtaR protein negatively regulates transcription of the gtaRI operon and modulates gene transfer agent (RcGTA) expression in Rhodobacter capsulatus. Molecular Microbiology. 83: 759-74. PMID 22211723 DOI: 10.1111/J.1365-2958.2011.07963.X  0.482
2010 Bolourani P, Spiegelman G, Weeks G. Determinants of RasC specificity during Dictyostelium aggregation. The Journal of Biological Chemistry. 285: 41374-9. PMID 20971846 DOI: 10.1074/Jbc.M110.181115  0.372
2010 Bolourani P, Spiegelman G, Weeks G. Ras proteins have multiple functions in vegetative cells of Dictyostelium. Eukaryotic Cell. 9: 1728-33. PMID 20833893 DOI: 10.1128/Ec.00141-10  0.429
2009 Seredick SD, Seredick BM, Baker D, Spiegelman GB. An A257V mutation in the bacillus subtilis response regulator Spo0A prevents regulated expression of promoters with low-consensus binding sites. Journal of Bacteriology. 191: 5489-98. PMID 19581368 DOI: 10.1128/Jb.00590-09  0.416
2008 Bolourani P, Spiegelman GB, Weeks G. Rap1 activation in response to cAMP occurs downstream of ras activation during Dictyostelium aggregation. The Journal of Biological Chemistry. 283: 10232-40. PMID 18180289 DOI: 10.1074/Jbc.M707459200  0.435
2007 Kae H, Kortholt A, Rehmann H, Insall RH, Van Haastert PJ, Spiegelman GB, Weeks G. Cyclic AMP signalling in Dictyostelium: G-proteins activate separate Ras pathways using specific RasGEFs. Embo Reports. 8: 477-82. PMID 17380187 DOI: 10.1038/Sj.Embor.7400936  0.411
2007 Seredick SD, Spiegelman GB. Bacillus subtilis RNA polymerase recruits the transcription factor Spo0A approximately P to stabilize a closed complex during transcription initiation. Journal of Molecular Biology. 366: 19-35. PMID 17157871 DOI: 10.1016/J.Jmb.2006.11.010  0.314
2006 Yim G, de la Cruz F, Spiegelman GB, Davies J. Transcription modulation of Salmonella enterica serovar Typhimurium promoters by sub-MIC levels of rifampin. Journal of Bacteriology. 188: 7988-91. PMID 16980465 DOI: 10.1128/Jb.00791-06  0.406
2006 Davies J, Spiegelman GB, Yim G. The world of subinhibitory antibiotic concentrations. Current Opinion in Microbiology. 9: 445-53. PMID 16942902 DOI: 10.1016/J.Mib.2006.08.006  0.304
2006 Bolourani P, Spiegelman GB, Weeks G. Delineation of the roles played by RasG and RasC in cAMP-dependent signal transduction during the early development of Dictyostelium discoideum. Molecular Biology of the Cell. 17: 4543-50. PMID 16885420 DOI: 10.1091/Mbc.E05-11-1019  0.452
2006 Secko DM, Siu CH, Spiegelman GB, Weeks G. An activated Ras protein alters cell adhesion by dephosphorylating Dictyostelium DdCAD-1. Microbiology (Reading, England). 152: 1497-505. PMID 16622066 DOI: 10.1099/Mic.0.28709-0  0.702
2006 Khosla M, Kriebel P, Parent CA, Spiegelman GB, Weeks G. A secondary disruption of the dmpA gene encoding a large membrane protein allows aggregation defective Dictyostelium rasC- cells to form multicellular structures. Developmental Biology. 292: 68-78. PMID 16490188 DOI: 10.1016/J.Ydbio.2005.12.051  0.458
2005 Khosla M, Spiegelman GB, Weeks G. The effect of the disruption of a gene encoding a PI4 kinase on the developmental defect exhibited by Dictyostelium rasC(-) cells. Developmental Biology. 284: 412-20. PMID 16023096 DOI: 10.1016/J.Ydbio.2005.05.037  0.436
2005 Lim CJ, Zawadzki KA, Khosla M, Secko DM, Spiegelman GB, Weeks G. Loss of the Dictyostelium RasC protein alters vegetative cell size, motility and endocytosis. Experimental Cell Research. 306: 47-55. PMID 15878331 DOI: 10.1016/J.Yexcr.2005.02.002  0.706
2005 McLeod BN, Spiegelman GB. Soj antagonizes Spo0A activation of transcription in Bacillus subtilis. Journal of Bacteriology. 187: 2532-6. PMID 15774898 DOI: 10.1128/Jb.187.7.2532-2536.2005  0.389
2004 Secko DM, Insall RH, Spiegelman GB, Weeks G. The identification of Dictyostelium phosphoproteins altered in response to the activation of RasG. Proteomics. 4: 2629-39. PMID 15352238 DOI: 10.1002/Pmic.200300788  0.662
2004 Wessels D, Brincks R, Kuhl S, Stepanovic V, Daniels KJ, Weeks G, Lim CJ, Spiegelman G, Fuller D, Iranfar N, Loomis WF, Soll DR. RasC plays a role in transduction of temporal gradient information in the cyclic-AMP wave of Dictyostelium discoideum. Eukaryotic Cell. 3: 646-62. PMID 15189986 DOI: 10.1128/Ec.3.3.646-662.2004  0.532
2004 Kae H, Lim CJ, Spiegelman GB, Weeks G. Chemoattractant-induced Ras activation during Dictyostelium aggregation. Embo Reports. 5: 602-6. PMID 15143344 DOI: 10.1038/Sj.Embor.7400151  0.58
2004 Seredick SD, Spiegelman GB. The Bacillus subtilis response regulator Spo0A stimulates sigmaA-dependent transcription prior to the major energetic barrier. The Journal of Biological Chemistry. 279: 17397-403. PMID 14976210 DOI: 10.1074/Jbc.M311190200  0.354
2003 Seredick SD, Turner BM, Spiegelman GB. Assay of transcription modulation by SpoOA of Bacillus subtilis. Methods in Enzymology. 370: 312-23. PMID 14712656 DOI: 10.1016/S0076-6879(03)70028-7  0.371
2003 Weeks G, Spiegelman GB. Roles played by Ras subfamily proteins in the cell and developmental biology of microorganisms. Cellular Signalling. 15: 901-9. PMID 12873703 DOI: 10.1016/S0898-6568(03)00073-1  0.382
2002 Lim CJ, Spiegelman GB, Weeks G. Cytoskeletal regulation by Dictyostelium Ras subfamily proteins. Journal of Muscle Research and Cell Motility. 23: 729-36. PMID 12952071 DOI: 10.1023/A:1024471527153  0.572
2002 Kang R, Kae H, Ip H, Spiegelman GB, Weeks G. Evidence for a role for the Dictyostelium Rap1 in cell viability and the response to osmotic stress. Journal of Cell Science. 115: 3675-82. PMID 12186953 DOI: 10.1242/Jcs.00039  0.474
2002 Lewis RJ, Scott DJ, Brannigan JA, Ladds JC, Cervin MA, Spiegelman GB, Hoggett JG, Barák I, Wilkinson AJ. Dimer formation and transcription activation in the sporulation response regulator Spo0A. Journal of Molecular Biology. 316: 235-45. PMID 11851334 DOI: 10.1006/Jmbi.2001.5331  0.405
2002 Dixon LG, Spiegelman GB. Glucose-resistant sporulation in Bacillus subtilis crsA47 mutants does not depend on promoter switching at the spo0A gene. Journal of Bacteriology. 184: 1458-61. PMID 11844779 DOI: 10.1128/Jb.184.5.1458-1461.2002  0.735
2001 Sutherland BW, Spiegelman GB, Weeks G. A Ras subfamily GTPase shows cell cycle-dependent nuclear localization. Embo Reports. 2: 1024-8. PMID 11606416 DOI: 10.1093/Embo-Reports/Kve222  0.381
2001 Lim CJ, Spiegelman GB, Weeks G. RasC is required for optimal activation of adenylyl cyclase and Akt/PKB during aggregation. The Embo Journal. 20: 4490-9. PMID 11500376 DOI: 10.1093/Emboj/20.16.4490  0.611
2001 Dixon LG, Seredick S, Richer M, Spiegelman GB. Developmental gene expression in Bacillus subtilis crsA47 mutants reveals glucose-activated control of the gene for the minor sigma factor sigma(H). Journal of Bacteriology. 183: 4814-22. PMID 11466285 DOI: 10.1128/Jb.183.16.4814-4822.2001  0.748
2001 Secko DM, Khosla M, Gaudet P, Tsang A, Spiegelman GB, Weeks G. RasG regulates discoidin gene expression during Dictyostelium growth. Experimental Cell Research. 266: 135-41. PMID 11339832 DOI: 10.1006/Excr.2001.5216  0.696
2001 Jaffer ZM, Khosla M, Spiegelman GB, Weeks G. Expression of activated Ras during Dictyostelium development alters cell localization and changes cell fate. Development (Cambridge, England). 128: 907-16. PMID 11222145  0.389
2000 Rowe-Magnus DA, Richer MJ, Spiegelman GB. Identification of a second region of the Spo0A response regulator of Bacillus subtilis required for transcription activation Journal of Bacteriology. 182: 4352-4355. PMID 10894748 DOI: 10.1128/Jb.182.15.4352-4355.2000  0.379
2000 Wilkins A, Khosla M, Fraser DJ, Spiegelman GB, Fisher PR, Weeks G, Insall RH. Dictyostelium RasD is required for normal phototaxis, but not differentiation Genes and Development. 14: 1407-1413. PMID 10837033 DOI: 10.1101/Gad.14.11.1407  0.412
2000 Cervin MA, Spiegelman GB. A role for Asp75 in domain interactions in the Bacillus subtilis response regulator Spo0A Journal of Biological Chemistry. 275: 22025-22030. PMID 10801786 DOI: 10.1074/Jbc.M000211200  0.353
2000 Khosla M, Spiegelman GB, Insall R, Weeks G. Functional overlap of the Dictyostelium RasG, RasD and RasB proteins Journal of Cell Science. 113: 1427-1434. PMID 10725225  0.391
1999 Zhang T, Rebstein PJ, Khosla M, Cardelli J, Buczynski G, Bush J, Spiegelman GB, Weeks G. A mutation that separates the RasG signals that regulate development and cytoskeletal function in Dictyostelium Experimental Cell Research. 247: 356-366. PMID 10066363 DOI: 10.1006/Excr.1998.4368  0.431
1999 Cervin MA, Spiegelman GB. The Spo0A sof mutations reveal regions of the regulatory domain that interact with a sensor kinase and RNA polymerase Molecular Microbiology. 31: 597-607. PMID 10027976 DOI: 10.1046/J.1365-2958.1999.01200.X  0.399
1999 Seastone DJ, Zhang L, Buczynski G, Rebstein P, Weeks G, Spiegelman G, Cardelli J. The small M(r) Ras-like GTPase Rap1 and the phospholipase C pathway act to regulate phagocytosis in Dictyostelium discoideum Molecular Biology of the Cell. 10: 393-406. PMID 9950684 DOI: 10.1091/Mbc.10.2.393  0.408
1998 Rowe-Magnus DA, Spiegelman GB. Contributions of the domains of the Bacillus subtilis response regulator Spo0A to transcription stimulation of the spoIIG operon Journal of Biological Chemistry. 273: 25818-25824. PMID 9748255 DOI: 10.1074/Jbc.273.40.25818  0.387
1998 Rowe-Magnus DA, Mencia M, Rojo F, Salas M, Spiegelman GB. Transcriptional activation of the Bacillus subtilis spoIIG promoter by the response regulator Spo0A is independent of the C-terminal domain of the RNA polymerase alpha subunit Journal of Bacteriology. 180: 4760-4763. PMID 9721325 DOI: 10.1128/Jb.180.17.4760-4763.1998  0.332
1998 Cervin MA, Spiegelman GB, Raether B, Ohlsen K, Perego M, Hoch JA. A negative regulator linking chromosome segregation to developmental transcription in Bacillus subtilis. Molecular Microbiology. 29: 85-95. PMID 9701805 DOI: 10.1046/J.1365-2958.1998.00905.X  0.468
1998 Cervin MA, Lewis RJ, Brannigan JA, Spiegelman GB. The Bacillus subtilis regulator SinR inhibits spollG promoter transcription in vitro without displacing RNA polymerase Nucleic Acids Research. 26: 3806-3812. PMID 9685500 DOI: 10.1093/Nar/26.16.3806  0.413
1998 Rowe-Magnus DA, Spiegelman GB. DNA strand separation during activation of a developmental promoter by the Bacillus subtilis response regulator Spo0A Proceedings of the National Academy of Sciences of the United States of America. 95: 5305-5310. PMID 9560271 DOI: 10.1073/Pnas.95.9.5305  0.421
1997 Mottus RC, Whitehead IP, O'Grady M, Sobel RE, Burr RH, Spiegelman GB, Grigliatti TA. Unique gene organization: alternative splicing in Drosophila produces two structurally unrelated proteins. Gene. 198: 229-36. PMID 9370286 DOI: 10.1016/S0378-1119(97)00319-3  0.376
1997 Louis SA, Weeks G, Spiegelman GB. Rap1 overexpression reveals that activated rasD induces separable defects during Dictyostelium development Developmental Biology. 190: 273-283. PMID 9344544 DOI: 10.1006/Dbio.1997.8675  0.451
1997 Louis SA, Spiegelman GB, Weeks G. Expression of an activated rasD gene changes cell fate decisions during Dictyostelium development Molecular Biology of the Cell. 8: 303-312. PMID 9190209 DOI: 10.1091/Mbc.8.2.303  0.452
1997 Rebstein PJ, Cardelli J, Weeks G, Spiegelman GB. Mutational analysis of the role of Rap1 in regulating cytoskeletal function in Dictyostelium Experimental Cell Research. 231: 276-283. PMID 9087168 DOI: 10.1006/Excr.1996.3466  0.444
1996 Khosla M, Spiegelman GB, Weeks G. Overexpression of an activated rasG gene during growth blocks the initiation of Dictyostelium development Molecular and Cellular Biology. 16: 4156-4162. PMID 8754814 DOI: 10.1128/Mcb.16.8.4156  0.453
1996 Anne Greene E, Spiegelman GB. The Spo0A protein of Bacillus subtilis inhibits transcription of the abrB gene without preventing binding of the polymerase to the promoter Journal of Biological Chemistry. 271: 11455-11461. PMID 8626703 DOI: 10.1074/Jbc.271.19.11455  0.437
1996 Bird TH, Grimsley JK, Hoch JA, Spiegelman GB. The Bacillus subtilis response regulator Spo0A stimulates transcription of the spoIIG operon through modification of RNA polymerase promoter complexes. Journal of Molecular Biology. 256: 436-48. PMID 8604129 DOI: 10.1006/Jmbi.1996.0099  0.406
1994 Khosla M, Spiegelman GB, Weeks G, Sands TW, Virdy KJ, Cotter DA. RasG protein accumulation occurs just prior to amoebae emergence during spore germination in Dictyostelium discoideum Fems Microbiology Letters. 117: 293-298. PMID 8200505 DOI: 10.1111/J.1574-6968.1994.Tb06782.X  0.332
1993 Clegg NJ, Whitehead IP, Williams JA, Spiegelman GB, Grigliatti TA. A developmental and molecular analysis of Cdc2 mutations in Drosophila melanogaster. Genome / National Research Council Canada = GéNome / Conseil National De Recherches Canada. 36: 676-85. PMID 8405984 DOI: 10.1139/G93-091  0.393
1993 Bush J, Franek K, Daniel J, Spiegelman GB, Weeks G, Cardelli J. Cloning and characterization of five novel Dictyostelium discoideum rab-related genes Gene. 136: 55-60. PMID 8294041 DOI: 10.1016/0378-1119(93)90447-B  0.421
1993 Bird TH, Grimsley JK, Hoch JA, Spiegelman GB. Phosphorylation of Spo0A activates its stimulation of in vitro transcription from the Bacillus subtilis spoIIG operon. Molecular Microbiology. 9: 741-9. PMID 8231806  0.355
1993 Rebstein PJ, Weeks G, Spiegelman GB. Altered morphology of vegetative amoebae induced by increased expression of the Dictyostelium discoideum ras-related gene rap1 Developmental Genetics. 14: 347-355. PMID 7507418 DOI: 10.1002/Dvg.1020140504  0.492
1992 Bird T, Burbulys D, Wu JJ, Strauch MA, Hoch JA, Spiegelman GB. The effect of supercoiling on the in vitro transcription of the spoIIA operon from Bacillus subtilis Biochimie. 74: 627-634. PMID 1391042 DOI: 10.1016/0300-9084(92)90134-Z  0.397
1992 Robbins SM, Williams JG, Spiegelman GB, Weeks G. Cloning and characterization of the Dictyostelium discoideum rasG genomic sequences. Biochimica Et Biophysica Acta. 1130: 85-9. PMID 1339294 DOI: 10.1016/0167-4781(92)90467-E  0.372
1992 Thiery R, Robbins S, Khosla M, Spiegelman GB, Weeks G. The effects of expression of an activated rasG mutation on the differentiation of Dictyostelium Biochemistry and Cell Biology = Biochimie Et Biologie Cellulaire. 70: 1193-1199. PMID 1297341 DOI: 10.1139/O92-165  0.413
1991 Robbins SM, Khosla M, Thiery R, Weeks G, Spiegelman GB. Ras-related genes in Dictyostelium discoideum. Developmental Genetics. 12: 147-53. PMID 2049874 DOI: 10.1002/Dvg.1020120123  0.422
1991 Perego M, Jiunn-Jong W, Spiegelman GB, Hoch JA. Mutational dissociation of the positive and negative regulatory properties of the SpoOA sporulation transcription factor of Bacillus subtilis Gene. 100: 207-212. PMID 1905258 DOI: 10.1016/0378-1119(91)90368-L  0.36
1990 Robbins SM, Suttorp VV, Weeks G, Spiegelman GB. A ras-related gene from the lower eukaryote Dictyostelium that is highly conserved relative to the human rap genes. Nucleic Acids Research. 18: 5265-9. PMID 2205839 DOI: 10.1093/Nar/18.17.5265  0.43
1990 Khosla M, Robbins SM, Spiegelman GB, Weeks G. Regulation of DdrasG gene expression during Dictyostelium development. Molecular and Cellular Biology. 10: 918-22. PMID 2154684 DOI: 10.1128/Mcb.10.3.918  0.441
1990 Strauch M, Webb V, Spiegelman G, Hoch JA. The SpoOA protein of Bacillus subtilis is a repressor of the abrB gene Proceedings of the National Academy of Sciences of the United States of America. 87: 1801-1805. PMID 2106683 DOI: 10.1073/Pnas.87.5.1801  0.457
1990 Strauch M, Perego M, Webb V, Spiegelman G, Hoch JA. CONTROL OF STATIONARY PHASE GENE EXPRESSION BY THE AMBIACTIVE AbrB TRANSCRIPTION REGULATOR Genetics and Biotechnology of Bacilli. 367-375. DOI: 10.1016/B978-0-12-274162-3.50043-8  0.4
1990 Trach K, Burbulys D, Spiegelman G, Perego M, Hoy BV, Strauch M, Day J, Hoch JA. PHOSPHORYLATION OF THE Spo0A PROTEIN: A CUMULATIVE ENVIRONSENSORY ACTIVATION MECHANISM Genetics and Biotechnology of Bacilli. 357-365. DOI: 10.1016/B978-0-12-274162-3.50042-6  0.346
1989 Robbins SM, Williams JG, Jermyn KA, Spiegelman GB, Weeks G. Growing and developing Dictyostelium cells express different ras genes. Proceedings of the National Academy of Sciences of the United States of America. 86: 938-42. PMID 2644652 DOI: 10.1073/Pnas.86.3.938  0.437
1989 Sajjadi FG, Spiegelman GB. The modulatory element TNNCT affects transcription of a Drosophila tRNA4 gene without affecting transcription complex stability Nucleic Acids Research. 17: 755-766. PMID 2492657 DOI: 10.1093/Nar/17.2.755  0.433
1988 Perego M, Spiegelman GB, Hoch JA. Structure of the gene for the transition state regulator, abrB: regulator synthesis is controlled by the spo0A sporulation gene in Bacillus subtilis Molecular Microbiology. 2: 689-699. PMID 3145384 DOI: 10.1111/j.1365-2958.1988.tb00079.x  0.37
1988 Mackay RM, Horvath D, Duncan L, Spiegelman GB. Heterologous 5' flanking regions do not support in vitro template activity of a Drosophila melanogaster tRNAVal3b gene Nucleic Acids Research. 16: 4137-4153. PMID 2836812 DOI: 10.1093/Nar/16.9.4137  0.422
1988 Horvath D, Spiegelman GB. Sequences between the internal control regions of tRNAArg of Drosophila melanogasrer influence stimulation of transcription of the 5′ flanking DNA Nucleic Acids Research. 16: 2585-2599. PMID 2834693 DOI: 10.1093/Nar/16.6.2585  0.397
1987 Sajjadi FG, Spiegelman GB. Modulation of a Drosophila melanogaster tRNA gene transcription in vitro by a sequence TNNCT in its 5′ flank Gene. 60: 13-19. PMID 3126098 DOI: 10.1016/0378-1119(87)90208-3  0.389
1987 Sajjadi FG, Miller RC, Spiegelman GB. Identification of sequences in the 5′ flanking region of a Drosophila melanogaster tRNA4Val gene that modulate its transcription in vitro Mgg Molecular &Amp; General Genetics. 206: 279-284. DOI: 10.1007/Bf00333585  0.394
1986 Whiteley HR, Ramey WD, Spiegelman GB, Holder RD. Modulation of in vivo and in vitro transcription of bacteriophage phi 29 early genes. Virology. 155: 392-401. PMID 3097957 DOI: 10.1016/0042-6822(86)90202-3  0.337
1985 Leung J, Addison WR, Delaney AD, MacKay RM, Miller RC, Spiegelman GB, Grigliatti TA, Tener GM. Drosophila melanogaster tRNAVal3b genes and their allogenes. Gene. 34: 207-17. PMID 3924738 DOI: 10.1016/0378-1119(85)90129-5  0.375
1985 Greenberg GR, St Louis D, Duncan L, Miller RC, Spiegelman GB. Partial purification of stable transcription complexes with cloned tRNA genes of Drosophila melanogaster Journal of Biological Chemistry. 260: 6248-6253. PMID 3922973  0.325
1985 Louis DS, Spiegelman GB. Steady-state kinetic analysis of transcription of cloned tRNASer genes from Drosophila melanogaster European Journal of Biochemistry. 148: 305-313. PMID 3921375 DOI: 10.1111/J.1432-1033.1985.Tb08840.X  0.431
1982 Rajput B, Duncan L, Demille D, Miller RC, Spiegelman GB. Transcription of cloned transfer RNA genes from Drosophila melanogaster in a homologous cell-free extract Nucleic Acids Research. 10: 6541-6550. PMID 6817302 DOI: 10.1093/Nar/10.20.6541  0.438
1982 Larsen TM, Miller RC, Spiegelman GB, Hayashi S, Tener GM, Sinclair DA, Grigliatti TA. RNA-DNA hybridization analyses of tRNA-Val-3b in Drosophila melanogaster. Molecular & General Genetics : Mgg. 185: 390-6. PMID 6808320 DOI: 10.1007/Bf00334129  0.308
1979 Spiegelman GB, Whiteley HR. Subunit composition of Bacillus subtilis RNA polymerase during transcription. Biochemical and Biophysical Research Communications. 87: 811-7. PMID 110325 DOI: 10.1016/0006-291X(79)92030-8  0.301
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