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Grant McFadden - Publications

Affiliations: 
University of Alberta, Edmonton, Alberta, Canada 
Area:
Biochemistry, Microbiology Biology
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308 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2023 Varkoly K, Beladi R, Hamada M, McFadden G, Irving J, Lucas AR. Viral SERPINS-A Family of Highly Potent Immune-Modulating Therapeutic Proteins. Biomolecules. 13. PMID 37759793 DOI: 10.3390/biom13091393  0.358
2023 Rahman MM, van Oosterom F, Enow JA, Hossain M, Gutierrez-Jensen AD, Cashen M, Everts A, Lowe K, Kilbourne J, Daggett-Vondras J, Karr TL, McFadden G. Nuclear Export Inhibitor Selinexor Enhances Oncolytic Myxoma Virus Therapy against Cancer. Cancer Research Communications. 3: 952-968. PMID 37377603 DOI: 10.1158/2767-9764.CRC-22-0483  0.336
2023 Rahman MM, Estifanos B, Glenn HL, Kibler K, Li Y, Jacobs B, McFadden G, Hogue BG. Nuclear export inhibitor Selinexor targeting XPO1 enhances coronavirus replication. Biorxiv : the Preprint Server For Biology. PMID 36824761 DOI: 10.1101/2023.02.09.527884  0.371
2022 Rahman MM, McFadden G, Ruthel G, Herbert DR, Freedman BD, Greenberg RM, Bais S. Oncolytic Myxoma virus infects and damages the tegument of the human parasitic flatworm Schistosoma mansoni. Experimental Parasitology. 108263. PMID 35598646 DOI: 10.1016/j.exppara.2022.108263  0.334
2022 Jazowiecka-Rakus J, Sochanik A, Hadryś A, Fidyk W, Chmielik E, Rahman MM, McFadden G. Combination of LIGHT (TNFSF14)-Armed Myxoma Virus Pre-Loaded into ADSCs and Gemcitabine in the Treatment of Experimental Orthotopic Murine Pancreatic Adenocarcinoma. Cancers. 14. PMID 35454928 DOI: 10.3390/cancers14082022  0.305
2022 Águeda-Pinto A, Kraberger S, Everts A, Gutierrez-Jensen A, Glenn HL, Dalton KP, Podadera A, Parra F, Martinez-Haro M, Viñuelas JA, Varsani A, McFadden G, Rahman MM, Esteves PJ. Identification of a Novel Myxoma Virus C7-Like Host Range Factor That Enabled a Species Leap from Rabbits to Hares. Mbio. e0346121. PMID 35352978 DOI: 10.1128/mbio.03461-21  0.339
2021 Águeda-Pinto A, Alves LQ, Neves F, McFadden G, Jacobs BL, Castro LFC, Rahman MM, Esteves PJ. Convergent Loss of the Necroptosis Pathway in Disparate Mammalian Lineages Shapes Viruses Countermeasures. Frontiers in Immunology. 12: 747737. PMID 34539677 DOI: 10.3389/fimmu.2021.747737  0.337
2021 Jazowiecka-Rakus J, Hadrys A, Rahman MM, McFadden G, Fidyk W, Chmielik E, Pazdzior M, Grajek M, Kozik V, Sochanik A. Myxoma Virus Expressing LIGHT (TNFSF14) Pre-Loaded into Adipose-Derived Mesenchymal Stem Cells Is Effective Treatment for Murine Pancreatic Adenocarcinoma. Cancers. 13. PMID 33808692 DOI: 10.3390/cancers13061394  0.342
2021 Liu Z, Nailwal H, Rector J, Rahman MM, Sam R, McFadden G, Chan FK. A class of viral inducer of degradation of the necroptosis adaptor RIPK3 regulates virus-induced inflammation. Immunity. PMID 33444549 DOI: 10.1016/j.immuni.2020.11.020  0.389
2021 Yaron JR, Zhang L, Burgin M, Schutz LN, Awo EA, Keinan S, McFadden G, Ambadapadi S, Guo Q, Chen H, Lucas AR. Deriving Immune-Modulating Peptides from Viral Serine Protease Inhibitors (Serpins). Methods in Molecular Biology (Clifton, N.J.). 2225: 107-123. PMID 33108660 DOI: 10.1007/978-1-0716-1012-1_7  0.304
2020 Jazowiecka-Rakus J, Sochanik A, Rusin A, Hadryś A, Fidyk W, Villa N, Rahman MM, Chmielik E, Franco LS, McFadden G. Myxoma Virus-Loaded Mesenchymal Stem Cells in Experimental Oncolytic Therapy of Murine Pulmonary Melanoma. Molecular Therapy Oncolytics. 18: 335-350. PMID 32775618 DOI: 10.1016/J.Omto.2020.07.003  0.413
2020 Villa NY, Rahman MM, Mamola J, D'Isabella J, Goras E, Kilbourne J, Lowe K, Daggett-Vondras J, Torres L, Christie J, Appel N, Cox AL, Kim JB, McFadden G. Autologous Transplantation Using Donor Leukocytes Loaded with Oncolytic Myxoma Virus Can Eliminate Residual Multiple Myeloma. Molecular Therapy Oncolytics. 18: 171-188. PMID 32695875 DOI: 10.1016/J.Omto.2020.06.011  0.375
2020 Rahman MM, McFadden G. Myxoma Virus-Encoded Host Range Protein M029: A Multifunctional Antagonist Targeting Multiple Host Antiviral and Innate Immune Pathways. Vaccines. 8. PMID 32456120 DOI: 10.3390/Vaccines8020244  0.497
2020 Águeda-Pinto A, Kraberger S, Lund MC, Gortázar C, McFadden G, Varsani A, Esteves PJ. Coinfections of Novel Polyomavirus, Anelloviruses and a Recombinant Strain of Myxoma Virus-MYXV-Tol Identified in Iberian Hares. Viruses. 12. PMID 32244962 DOI: 10.3390/V12030340  0.371
2020 Yaron JR, Zhang L, Guo Q, Burgin M, Schutz LN, Awo E, Wise L, Krause KL, Ildefonso CJ, Kwiecien JM, Juby M, Rahman MM, Chen H, Moyer RW, Alcami A, ... McFadden G, et al. Deriving Immune Modulating Drugs from Viruses-A New Class of Biologics. Journal of Clinical Medicine. 9. PMID 32244484 DOI: 10.3390/Jcm9040972  0.445
2020 Lemos de Matos A, Franco LS, McFadden G. Oncolytic Viruses and the Immune System: The Dynamic Duo. Molecular Therapy. Methods & Clinical Development. 17: 349-358. PMID 32071927 DOI: 10.1016/J.Omtm.2020.01.001  0.435
2020 Hadryś A, Sochanik A, McFadden G, Jazowiecka-Rakus J. Mesenchymal stem cells as carriers for systemic delivery of oncolytic viruses. European Journal of Pharmacology. 874: 172991. PMID 32044323 DOI: 10.1016/J.Ejphar.2020.172991  0.369
2020 Tang B, Guo ZS, Bartlett DL, Yan DZ, Schane CP, Liu J, McFadden G, Thomas DL, Shisler JL, Roy EJ. Synergistic Combination of Oncolytic Virotherapy and Immunotherapy for Glioma. Clinical Cancer Research : An Official Journal of the American Association For Cancer Research. PMID 32019860 DOI: 10.1158/1078-0432.Ccr-18-3626  0.329
2020 Rahman MM, McFadden G. Oncolytic Virotherapy with Myxoma Virus. Journal of Clinical Medicine. 9. PMID 31936317 DOI: 10.3390/Jcm9010171  0.424
2020 Rodrigues TCS, Subramaniam K, Varsani A, McFadden G, Schaefer AM, Bossart GD, Romero CH, Waltzek TB. Genome characterization of cetaceanpox virus from a managed Indo-Pacific bottlenose dolphin (Tursiops aduncus). Virus Research. 197861. PMID 31923559 DOI: 10.1016/J.Virusres.2020.197861  0.323
2020 Villa NY, Franco LS, McFadden G. Ex Vivo Virotherapy with Myxoma Virus to Treat Cancer. Methods in Molecular Biology (Clifton, N.J.). 2058: 95-110. PMID 31486033 DOI: 10.1007/978-1-4939-9794-7_6  0.454
2020 Ortegon S, Franco LS, McFadden G, Cordovez J. Mathematical model of oncolytic virotherapy with Myxoma virus infection in cancer cells The Faseb Journal. 34: 1-1. DOI: 10.1096/Fasebj.2020.34.S1.07088  0.416
2019 van Vloten JP, Klafuric EM, Karimi K, McFadden G, Petrik JJ, Wootton SK, Bridle BW. Quantifying Antibody Responses Induced by Antigen-Agnostic Immunotherapies. Molecular Therapy. Methods & Clinical Development. 14: 189-196. PMID 31388514 DOI: 10.1016/J.Omtm.2019.06.010  0.349
2019 Águeda-Pinto A, Lemos de Matos A, Abrantes M, Kraberger S, Risalde MA, Gortázar C, McFadden G, Varsani A, Esteves PJ. Genetic Characterization of a Recombinant Myxoma Virus in the Iberian Hare (). Viruses. 11. PMID 31181645 DOI: 10.3390/V11060530  0.408
2019 Kellish P, Shabashvili D, Rahman MM, Nawab A, Guijarro MV, Zhang M, Cao C, Moussatche N, Boyle T, Antonia S, Reinhard M, Hartzell C, Jantz M, Mehta HJ, McFadden G, et al. Oncolytic virotherapy for small-cell lung cancer induces immune infiltration and prolongs survival. The Journal of Clinical Investigation. 130. PMID 31033480 DOI: 10.1172/Jci121323  0.369
2019 Garg RR, Jackson CB, Rahman MM, Khan AR, Lewin AS, McFadden G. Myxoma virus M013 protein antagonizes NF-κB and inflammasome pathways via distinct structural motifs. The Journal of Biological Chemistry. PMID 30940649 DOI: 10.1074/Jbc.Ra118.006040  0.347
2019 Torres-Domínguez LE, McFadden G. Poxvirus oncolytic virotherapy. Expert Opinion On Biological Therapy. 1-13. PMID 30919708 DOI: 10.1080/14712598.2019.1600669  0.383
2019 Tang B, Guo ZS, Bartlett DL, Liu J, McFadden G, Shisler JL, Roy EJ. A cautionary note on the selectivity of oncolytic poxviruses. Oncolytic Virotherapy. 8: 3-8. PMID 30805315 DOI: 10.2147/OV.S189832  0.312
2019 van Vloten JP, Santry LA, McAusland TM, Karimi K, McFadden G, Petrik JJ, Wootton SK, Bridle BW. Quantifying Antigen-Specific T Cell Responses When Using Antigen-Agnostic Immunotherapies. Molecular Therapy. Methods & Clinical Development. 13: 154-166. PMID 30788384 DOI: 10.1016/J.Omtm.2019.01.012  0.32
2019 Alves JM, Carneiro M, Cheng JY, Lemos de Matos A, Rahman MM, Loog L, Campos PF, Wales N, Eriksson A, Manica A, Strive T, Graham SC, Afonso S, Bell DJ, Belmont L, ... ... McFadden G, et al. Parallel adaptation of rabbit populations to myxoma virus. Science (New York, N.Y.). PMID 30765607 DOI: 10.1126/Science.Aau7285  0.359
2019 Tang B, Guo ZS, Bartlett DL, Yan D, Schane CP, Liu J, McFadden G, Shisler JL, Roy EJ. Abstract 2264: Synergistic combination of oncolytic virotherapy and immunotherapy for glioma Cancer Research. 79: 2264-2264. DOI: 10.1158/1538-7445.Am2019-2264  0.416
2019 Kellish P, Hartzell C, Shabashvili D, Rahman MM, Guijarro MV, Nawab A, McFadden G, Kaye FJ, Zajac-Kaye M. Abstract 1465: Priming immunity against SCLC with oncolytic virotherapy Cancer Research. 79: 1465-1465. DOI: 10.1158/1538-7445.Am2019-1465  0.38
2018 Villa NY, McFadden G. Virotherapy as Potential Adjunct Therapy for Graft-Vs-Host Disease. Current Pathobiology Reports. 6: 247-263. PMID 30595970 DOI: 10.1007/S40139-018-0186-6  0.301
2018 Phelps MP, Yang H, Patel S, Rahman MM, McFadden G, Chen E. Oncolytic Virus-Mediated RAS Targeting in Rhabdomyosarcoma. Molecular Therapy Oncolytics. 11: 52-61. PMID 30364635 DOI: 10.1016/J.Omto.2018.09.001  0.37
2018 Lucas A, Yaron JR, Zhang L, Macaulay C, McFadden G. Serpins: Development for Therapeutic Applications. Methods in Molecular Biology (Clifton, N.J.). 1826: 255-265. PMID 30194606 DOI: 10.1007/978-1-4939-8645-3_17  0.366
2018 Esteves PJ, Abrantes J, Baldauf HM, BenMohamed L, Chen Y, Christensen N, González-Gallego J, Giacani L, Hu J, Kaplan G, Keppler OT, Knight KL, Kong XP, Lanning DK, Le Pendu J, ... ... McFadden G, et al. The wide utility of rabbits as models of human diseases. Experimental & Molecular Medicine. 50: 66. PMID 29789565 DOI: 10.1038/S12276-018-0094-1  0.334
2017 Rahman MM, Bagdassarian E, Ali MAM, McFadden G. Identification of host DEAD-box RNA helicases that regulate cellular tropism of oncolytic Myxoma virus in human cancer cells. Scientific Reports. 7: 15710. PMID 29146961 DOI: 10.1038/S41598-017-15941-1  0.415
2017 Lilly CL, Villa NY, Lemos de Matos A, Ali HM, Dhillon JS, Hofland T, Rahman MM, Chan W, Bogen B, Cogle C, McFadden G. Ex Vivo Oncolytic Virotherapy with Myxoma Virus Arms Multiple Allogeneic Bone Marrow Transplant Leukocytes to Enhance Graft versus Tumor. Molecular Therapy Oncolytics. 4: 31-40. PMID 28345022 DOI: 10.1016/J.Omto.2016.12.002  0.378
2017 Rahman MM, McFadden G. Myxoma Virus dsRNA Binding Protein M029  Inhibits the Type I IFN-Induced Antiviral State in a  Highly Species-Specific Fashion. Viruses. 9. PMID 28157174 DOI: 10.3390/V9020027  0.425
2017 Kellish P, Shabashvili D, Rahman MM, Reinhard M, McFadden G, Kaye F, Zajac-Kaye M. Abstract 1609: Oncolytic virotherapy for SCLC using immunocompetent mouse models Cancer Research. 77: 1609-1609. DOI: 10.1158/1538-7445.Am2017-1609  0.399
2016 Andrade LG, Albarnaz JD, Mügge FL, David BA, Abrahão JS, da Fonseca FG, Kroon EG, Menezes GB, McFadden G, Bonjardim CA. Vaccinia virus dissemination requires p21-activated kinase 1. Archives of Virology. PMID 27465567 DOI: 10.1007/S00705-016-2996-3  0.426
2016 Villa NY, Rahman MM, McFadden G, Cogle CR. Therapeutics for Graft-versus-Host Disease: From Conventional Therapies to Novel Virotherapeutic Strategies. Viruses. 8. PMID 27011200 DOI: 10.3390/V8030085  0.34
2016 Pisklakova A, McKenzie B, Zemp F, Lun X, Kenchappa RS, Etame AB, Rahman MM, Reilly K, Pilon-Thomas S, McFadden G, Kurz E, Forsyth PA. M011L-deficient oncolytic myxoma virus induces apoptosis in brain tumor-initiating cells and enhances survival in a novel immunocompetent mouse model of glioblastoma. Neuro-Oncology. PMID 26962017 DOI: 10.1093/Neuonc/Now006  0.443
2016 Peng C, Haller SL, Rahman MM, McFadden G, Rothenburg S. Myxoma virus M156 is a specific inhibitor of rabbit PKR but contains a loss-of-function mutation in Australian virus isolates. Proceedings of the National Academy of Sciences of the United States of America. PMID 26903626 DOI: 10.1073/Pnas.1515613113  0.442
2016 Villa NY, Bais S, Chan WM, Meacham AM, Wise E, Rahman MM, Moreb JS, Rosenau EH, Wingard JR, McFadden G, Cogle CR. Ex vivo virotherapy with myxoma virus does not impair hematopoietic stem and progenitor cells. Cytotherapy. 18: 465-80. PMID 26857235 DOI: 10.1016/J.Jcyt.2015.12.007  0.368
2016 Kenchappa R, McKenzie B, Pisklakova A, McFadden G, Forsyth PAJ. M011L-deficient oncolytic myxoma virus to induce apoptosis in brain tumor initiating cells and to enhance survival in a novel immunocompetent mouse model of glioblastoma. Journal of Clinical Oncology. 34. DOI: 10.1200/Jco.2016.34.15_Suppl.E13521  0.448
2015 Tong JG, Valdes YR, Barrett JW, Bell JC, Stojdl D, McFadden G, McCart JA, DiMattia GE, Shepherd TG. Evidence for differential viral oncolytic efficacy in an in vitro model of epithelial ovarian cancer metastasis. Molecular Therapy Oncolytics. 2: 15013. PMID 27119108 DOI: 10.1038/Mto.2015.13  0.471
2015 Bell JC, McFadden G. Editorial overview: Oncolytic viruses--replicating virus therapeutics for the treatment of cancer. Current Opinion in Virology. 13: viii-ix. PMID 26260227 DOI: 10.1016/J.Coviro.2015.07.005  0.413
2015 McFadden G. The Curious Road from Basic Pathogen Research to Clinical Translation. Plos Pathogens. 11: e1004997. PMID 26110645 DOI: 10.1371/Journal.Ppat.1004997  0.427
2015 Villa NY, Wasserfall CH, Meacham AM, Wise E, Chan W, Wingard JR, McFadden G, Cogle CR. Myxoma virus suppresses proliferation of activated T lymphocytes yet permits oncolytic virus transfer to cancer cells. Blood. 125: 3778-88. PMID 25904246 DOI: 10.1182/Blood-2014-07-587329  0.435
2015 Kim M, Rahman MM, Cogle CR, McFadden G. Prevention of EBV lymphoma development by oncolytic myxoma virus in a murine xenograft model of post-transplant lymphoproliferative disease. Biochemical and Biophysical Research Communications. 462: 283-7. PMID 25843801 DOI: 10.1016/J.Bbrc.2015.03.146  0.363
2015 Boutard B, Vankerckhove S, Markine-Goriaynoff N, Sarlet M, Desmecht D, McFadden G, Vanderplasschen A, Gillet L. The α2,3-sialyltransferase encoded by myxoma virus is a virulence factor that contributes to immunosuppression. Plos One. 10: e0118806. PMID 25705900 DOI: 10.1371/Journal.Pone.0118806  0.429
2015 McKenzie BA, Zemp FJ, Pisklakova A, Narendran A, McFadden G, Lun X, Kenchappa RS, Kurz EU, Forsyth PA. In vitro screen of a small molecule inhibitor drug library identifies multiple compounds that synergize with oncolytic myxoma virus against human brain tumor-initiating cells. Neuro-Oncology. 17: 1086-94. PMID 25605818 DOI: 10.1093/Neuonc/Nou359  0.41
2015 Liu J, McFadden G. SAMD9 is an innate antiviral host factor with stress response properties that can be antagonized by poxviruses. Journal of Virology. 89: 1925-31. PMID 25428864 DOI: 10.1128/Jvi.02262-14  0.427
2015 Ildefonso CJ, Jaime H, Rahman MM, Li Q, Boye SE, Hauswirth WW, Lucas AR, McFadden G, Lewin AS. Gene delivery of a viral anti-inflammatory protein to combat ocular inflammation. Human Gene Therapy. 26: 59-68. PMID 25420215 DOI: 10.1089/Hum.2014.089  0.377
2015 Pisklakova A, McKenzie B, Zemp F, Kenchappa R, McFadden G, Forsyth P. Atps-65An Oncolytic Myxoma Virus Construct (M011L Knock-Out) Induces Apoptosis And Is A Potent Pro-Apoptotic Therapy In Both Human And Immunocompetent Murine Glioblastoma Cancer Stem Cells Models Neuro-Oncology. 17. DOI: 10.1093/Neuonc/Nov204.65  0.448
2015 Ildefonso CJ, Jaime H, Li Q, Rahman MM, McFadden G, Lewin AS. 607. Gene Therapy Delivering Anti-inflammatory Viral Proteins for Ocular Inflammation Molecular Therapy. 23: S241. DOI: 10.1016/S1525-0016(16)34216-2  0.364
2014 Zemp FJ, McKenzie BA, Lun X, Reilly KM, McFadden G, Yong VW, Forsyth PA. Cellular factors promoting resistance to effective treatment of glioma with oncolytic myxoma virus. Cancer Research. 74: 7260-73. PMID 25336188 DOI: 10.1158/0008-5472.Can-14-0876  0.459
2014 Tosic V, Thomas DL, Kranz DM, Liu J, McFadden G, Shisler JL, MacNeill AL, Roy EJ. Myxoma virus expressing a fusion protein of interleukin-15 (IL15) and IL15 receptor alpha has enhanced antitumor activity. Plos One. 9: e109801. PMID 25329832 DOI: 10.1371/Journal.Pone.0109801  0.386
2014 Lamb SA, Rahman MM, McFadden G. Recombinant myxoma virus lacking all poxvirus ankyrin-repeat proteins stimulates multiple cellular anti-viral pathways and exhibits a severe decrease in virulence. Virology. 464: 134-45. PMID 25068401 DOI: 10.1016/J.Virol.2014.06.021  0.452
2014 Brahn E, Lee S, Lucas A, McFadden G, Macaulay C. Suppression of collagen-induced arthritis with a serine proteinase inhibitor (serpin) derived from myxoma virus. Clinical Immunology (Orlando, Fla.). 153: 254-63. PMID 24845791 DOI: 10.1016/J.Clim.2014.05.003  0.451
2014 Weng M, Gong W, Ma M, Chu B, Qin Y, Zhang M, Lun X, McFadden G, Forsyth P, Yang Y, Quan Z. Targeting gallbladder cancer: oncolytic virotherapy with myxoma virus is enhanced by rapamycin in vitro and further improved by hyaluronan in vivo. Molecular Cancer. 13: 82. PMID 24725816 DOI: 10.1186/1476-4598-13-82  0.377
2014 Bell J, McFadden G. Viruses for tumor therapy. Cell Host & Microbe. 15: 260-5. PMID 24629333 DOI: 10.1016/J.Chom.2014.01.002  0.389
2014 Lemos de Matos A, McFadden G, Esteves PJ. Evolution of viral sensing RIG-I-like receptor genes in Leporidae genera Oryctolagus, Sylvilagus, and Lepus. Immunogenetics. 66: 43-52. PMID 24220721 DOI: 10.1007/S00251-013-0740-7  0.431
2014 Haller SL, Peng C, McFadden G, Rothenburg S. Poxviruses and the evolution of host range and virulence. Infection, Genetics and Evolution : Journal of Molecular Epidemiology and Evolutionary Genetics in Infectious Diseases. 21: 15-40. PMID 24161410 DOI: 10.1016/J.Meegid.2013.10.014  0.405
2014 Forsyth PAJ, McKenzie B, Pisklakova A, Kenchappa R, McFadden G. Oncolytic viral therapy for malignant gliomas using myxoma virus deleted for antiapoptotic M11L gene. Journal of Clinical Oncology. 32: 3105-3105. DOI: 10.1200/Jco.2014.32.15_Suppl.3105  0.443
2014 Davids JA, Dai E, Chen H, Bartee MY, Liu L, Fortunel A, Moyer R, McFadden G, Lucas AR. Viral Anti-Inflammatory Proteins Target Diverging Immune Pathways with Converging Effects on Arterial Dilatation, Plaque and Apoptosis European Journal of Inflammation. 12: 131-145. DOI: 10.1177/1721727X1401200113  0.359
2014 Pisklakova A, McKenzie B, Kenchappa R, McFadden G, Forsyth P. Et-46Oncolytic Viral Therapy For Malignant Gliomas Using Myxoma Virus Deleted For Anti-Apoptotic M11L Gene Neuro-Oncology. 16. DOI: 10.1093/Neuonc/Nou255.44  0.471
2013 Zheng D, Chen H, Bartee MY, Williams J, Davids JA, Lomas DA, McFadden G, Lucas AR. Myxomaviral Anti-Inflammatory Serpin Reduces Myeloid-Derived Suppressor Cells and Human Pancreatic Cancer Cell Growth in Mice. Journal of Cancer Science & Therapy. 5: 291-299. PMID 25798214 DOI: 10.4172/1948-5956.1000219  0.347
2013 Lemos de Matos A, McFadden G, Esteves PJ. Positive evolutionary selection on the RIG-I-like receptor genes in mammals. Plos One. 8: e81864. PMID 24312370 DOI: 10.1371/Journal.Pone.0081864  0.348
2013 Chen H, Davids JA, Zheng D, Bryant M, Bot I, van Berckel TJ, Biessen E, Pepine C, Ryman K, Progulski-Fox A, Kesavalu L, Moyer R, McFadden G, Lucas A. The serpin solution; targeting thrombotic and thrombolytic serine proteases in inflammation. Cardiovascular & Hematological Disorders Drug Targets. 13: 99-110. PMID 23987998 DOI: 10.2174/1871529X11313020003  0.366
2013 Rahman MM, Liu J, Chan WM, Rothenburg S, McFadden G. Myxoma virus protein M029 is a dual function immunomodulator that inhibits PKR and also conscripts RHA/DHX9 to promote expanded host tropism and viral replication. Plos Pathogens. 9: e1003465. PMID 23853588 DOI: 10.1371/Journal.Ppat.1003465  0.465
2013 Chen H, Zheng D, Abbott J, Liu L, Bartee MY, Long M, Davids J, Williams J, Feldmann H, Strong J, Grau KR, Tibbetts S, Macaulay C, McFadden G, Thoburn R, et al. Myxomavirus-derived serpin prolongs survival and reduces inflammation and hemorrhage in an unrelated lethal mouse viral infection. Antimicrobial Agents and Chemotherapy. 57: 4114-27. PMID 23774438 DOI: 10.1128/Aac.02594-12  0.435
2013 Ogbomo H, Zemp FJ, Lun X, Zhang J, Stack D, Rahman MM, McFadden G, Mody CH, Forsyth PA. Myxoma virus infection promotes NK lysis of malignant gliomas in vitro and in vivo. Plos One. 8: e66825. PMID 23762498 DOI: 10.1371/Journal.Pone.0066825  0.393
2013 Zemp FJ, McKenzie BA, Lun X, Maxwell L, Reilly KM, McFadden G, Yong VW, Forsyth PA. Resistance to oncolytic myxoma virus therapy in nf1(-/-)/trp53(-/-) syngeneic mouse glioma models is independent of anti-viral type-I interferon. Plos One. 8: e65801. PMID 23762429 DOI: 10.1371/Journal.Pone.0065801  0.431
2013 Lemos de Matos A, Liu J, McFadden G, Esteves PJ. Evolution and divergence of the mammalian SAMD9/SAMD9L gene family. Bmc Evolutionary Biology. 13: 121. PMID 23758988 DOI: 10.1186/1471-2148-13-121  0.32
2013 Chan WM, Rahman MM, McFadden G. Oncolytic myxoma virus: the path to clinic. Vaccine. 31: 4252-8. PMID 23726825 DOI: 10.1016/J.Vaccine.2013.05.056  0.397
2013 Bartee E, McFadden G. Cytokine synergy: an underappreciated contributor to innate anti-viral immunity. Cytokine. 63: 237-40. PMID 23693158 DOI: 10.1016/J.Cyto.2013.04.036  0.402
2013 Zemp FJ, Lun X, McKenzie BA, Zhou H, Maxwell L, Sun B, Kelly JJ, Stechishin O, Luchman A, Weiss S, Cairncross JG, Hamilton MG, Rabinovich BA, Rahman MM, Mohamed MR, ... ... McFadden G, et al. Treating brain tumor-initiating cells using a combination of myxoma virus and rapamycin. Neuro-Oncology. 15: 904-20. PMID 23585629 DOI: 10.1093/Neuonc/Not035  0.381
2013 Jenne CN, Wong CH, Zemp FJ, McDonald B, Rahman MM, Forsyth PA, McFadden G, Kubes P. Neutrophils recruited to sites of infection protect from virus challenge by releasing neutrophil extracellular traps. Cell Host & Microbe. 13: 169-80. PMID 23414757 DOI: 10.1016/J.Chom.2013.01.005  0.42
2013 Chan WM, Bartee EC, Moreb JS, Dower K, Connor JH, McFadden G. Myxoma and vaccinia viruses bind differentially to human leukocytes. Journal of Virology. 87: 4445-60. PMID 23388707 DOI: 10.1128/Jvi.03488-12  0.383
2013 Jeng D, Ma Z, Barrett JW, McFadden G, Loeb JA, Essani K. The tanapoxvirus 15L protein is a virus-encoded neuregulin that promotes viral replication in human endothelial cells. Journal of Virology. 87: 3018-26. PMID 23269801 DOI: 10.1128/Jvi.02112-12  0.467
2013 Liu L, Dai E, BaktiarKidwai, Davids J, Macaulay C, McFadden G, Alex, Lucas r. Comparative Analysis of Plaque Growth after Arterial Stent Implant with Anti-Inflammatory Chemokine and Serine Protease Inhibitors Treatment Journal of Clinical and Experimental Cardiology. 4: 1-9. DOI: 10.4172/2155-9880.1000274  0.316
2013 Tosic V, Thomas DL, Kranz DM, Liu J, McFadden G, MacNeill AL, Roy EJ. Interleukin-15 (IL-15) and IL-15 receptor alpha fusion protein enhances antitumor activity of myxoma virus Journal For Immunotherapy of Cancer. 1. DOI: 10.1186/2051-1426-1-S1-P137  0.421
2013 Chen H, Zheng D, Liu L, Bartee MY, Davids J, Macaulay C, Strong J, Feldmann H, McFadden G, Lomas DA, Virgin HW, Lucas A. 40 Cytokine. 63: 252-253. DOI: 10.1016/J.Cyto.2013.06.043  0.389
2012 Liu J, Rothenburg S, McFadden G. The poxvirus C7L host range factor superfamily. Current Opinion in Virology. 2: 764-72. PMID 23103013 DOI: 10.1016/J.Coviro.2012.09.012  0.374
2012 Bartee E, Meacham A, Wise E, Cogle CR, McFadden G. Virotherapy using myxoma virus prevents lethal graft-versus-host disease following xeno-transplantation with primary human hematopoietic stem cells. Plos One. 7: e43298. PMID 22905251 DOI: 10.1371/Journal.Pone.0043298  0.364
2012 Cao H, Dai P, Wang W, Li H, Yuan J, Wang F, Fang CM, Pitha PM, Liu J, Condit RC, McFadden G, Merghoub T, Houghton AN, Young JW, Shuman S, et al. Innate immune response of human plasmacytoid dendritic cells to poxvirus infection is subverted by vaccinia E3 via its Z-DNA/RNA binding domain. Plos One. 7: e36823. PMID 22606294 DOI: 10.1371/Journal.Pone.0036823  0.48
2012 Bartee E, Chan WM, Moreb JS, Cogle CR, McFadden G. Selective purging of human multiple myeloma cells from autologous stem cell transplantation grafts using oncolytic myxoma virus. Biology of Blood and Marrow Transplantation : Journal of the American Society For Blood and Marrow Transplantation. 18: 1540-51. PMID 22516053 DOI: 10.1016/J.Bbmt.2012.04.004  0.384
2012 Liu J, Wennier S, Moussatche N, Reinhard M, Condit R, McFadden G. Myxoma virus M064 is a novel member of the poxvirus C7L superfamily of host range factors that controls the kinetics of myxomatosis in European rabbits. Journal of Virology. 86: 5371-5. PMID 22379095 DOI: 10.1128/Jvi.06933-11  0.339
2012 Madlambayan GJ, Bartee E, Kim M, Rahman MM, Meacham A, Scott EW, McFadden G, Cogle CR. Acute myeloid leukemia targeting by myxoma virus in vivo depends on cell binding but not permissiveness to infection in vitro. Leukemia Research. 36: 619-24. PMID 22341701 DOI: 10.1016/J.Leukres.2012.01.020  0.464
2012 Bais S, Bartee E, Rahman MM, McFadden G, Cogle CR. Oncolytic virotherapy for hematological malignancies. Advances in Virology. 2012: 186512. PMID 22312362 DOI: 10.1155/2012/186512  0.392
2012 Correa RJ, Komar M, Tong JG, Sivapragasam M, Rahman MM, McFadden G, Dimattia GE, Shepherd TG. Myxoma virus-mediated oncolysis of ascites-derived human ovarian cancer cells and spheroids is impacted by differential AKT activity. Gynecologic Oncology. 125: 441-50. PMID 22306204 DOI: 10.1016/J.Ygyno.2012.01.048  0.39
2012 Wennier ST, Liu J, Li S, Rahman MM, Mona M, McFadden G. Myxoma virus sensitizes cancer cells to gemcitabine and is an effective oncolytic virotherapeutic in models of disseminated pancreatic cancer. Molecular Therapy : the Journal of the American Society of Gene Therapy. 20: 759-68. PMID 22233582 DOI: 10.1038/Mt.2011.293  0.366
2012 McKenzie B, Zemp FJ, Lun X, Narendran A, McFadden G, Kurz E, Forsyth P. Abstract LB-140: Targeting brain tumour initiating cells using a dual-pronged approach of oncolytic virotherapy and chemotherapeutics Cancer Research. 72. DOI: 10.1158/1538-7445.Am2012-Lb-140  0.359
2012 Ogbomo H, Lun X, Zhang J, Zemp FJ, Mcfadden G, Mody CH, Forsyth PA. Abstract 1558: Innovative biotherapy for brain tumors: Myxoma virus accelerates NK clearance of malignant gliomas Cancer Research. 72: 1558-1558. DOI: 10.1158/1538-7445.Am2012-1558  0.346
2011 Rahman MM, McFadden G. Myxoma virus lacking the pyrin-like protein M013 is sensed in human myeloid cells by both NLRP3 and multiple Toll-like receptors, which independently activate the inflammasome and NF-κB innate response pathways. Journal of Virology. 85: 12505-17. PMID 21957307 DOI: 10.1128/Jvi.00410-11  0.416
2011 Dai P, Cao H, Merghoub T, Avogadri F, Wang W, Parikh T, Fang CM, Pitha PM, Fitzgerald KA, Rahman MM, McFadden G, Hu X, Houghton AN, Shuman S, Deng L. Myxoma virus induces type I interferon production in murine plasmacytoid dendritic cells via a TLR9/MyD88-, IRF5/IRF7-, and IFNAR-dependent pathway. Journal of Virology. 85: 10814-25. PMID 21835795 DOI: 10.1128/Jvi.00104-11  0.488
2011 Chen H, Zheng D, Davids J, Bartee MY, Dai E, Liu L, Petrov L, Macaulay C, Thoburn R, Sobel E, Moyer R, McFadden G, Lucas A. Viral serpin therapeutics from concept to clinic. Methods in Enzymology. 499: 301-29. PMID 21683260 DOI: 10.1016/B978-0-12-386471-0.00015-8  0.38
2011 Spiesschaert B, McFadden G, Hermans K, Nauwynck H, Van de Walle GR. The current status and future directions of myxoma virus, a master in immune evasion. Veterinary Research. 42: 76. PMID 21658227 DOI: 10.1186/1297-9716-42-76  0.439
2011 Thomas DL, Doty R, Tosic V, Liu J, Kranz DM, McFadden G, Macneill AL, Roy EJ. Myxoma virus combined with rapamycin treatment enhances adoptive T cell therapy for murine melanoma brain tumors. Cancer Immunology, Immunotherapy : Cii. 60: 1461-72. PMID 21656158 DOI: 10.1007/S00262-011-1045-Z  0.42
2011 Smallwood SE, Rahman MM, Werden SJ, Martino MF, McFadden G. Production of Myxoma virus gateway entry and expression libraries and validation of viral protein expression. Current Protocols in Microbiology. Unit 14A.2. PMID 21538302 DOI: 10.1002/9780471729259.Mc14A02S21  0.492
2011 Jeng D, Rahman MM, McFadden G, Essani K. Tumor necrosis factor inhibitors from poxviruses with an emphasis on tanapoxvirus-2L protein. Recent Patents On Dna & Gene Sequences. 5: 97-103. PMID 21529335 DOI: 10.2174/187221511796392033  0.416
2011 Rahman MM, McFadden G. Modulation of NF-κB signalling by microbial pathogens. Nature Reviews. Microbiology. 9: 291-306. PMID 21383764 DOI: 10.1038/Nrmicro2539  0.342
2011 Liu J, Wennier S, Zhang L, McFadden G. M062 is a host range factor essential for myxoma virus pathogenesis and functions as an antagonist of host SAMD9 in human cells. Journal of Virology. 85: 3270-82. PMID 21248034 DOI: 10.1128/Jvi.02243-10  0.471
2011 France MR, Thomas DL, Liu J, McFadden G, MacNeill AL, Roy EJ. Intraventricular injection of myxoma virus results in transient expression of viral protein in mouse brain ependymal and subventricular cells. The Journal of General Virology. 92: 195-9. PMID 20861319 DOI: 10.1099/Vir.0.026690-0  0.466
2011 Gong W, Zhou D, Zhang Y, Lun X, Forsyth P, McFadden G, Quan Z. Myxoma virus is oncolytic for primary and metastatic human gastric cancer cells Journal of the American College of Surgeons. 213. DOI: 10.1016/J.Jamcollsurg.2011.06.353  0.353
2010 Liu J, Wennier S, McFadden G. The immunoregulatory properties of oncolytic myxoma virus and their implications in therapeutics. Microbes and Infection / Institut Pasteur. 12: 1144-52. PMID 20832500 DOI: 10.1016/J.Micinf.2010.08.012  0.45
2010 Kim M, Williamson CT, Prudhomme J, Bebb DG, Riabowol K, Lee PW, Lees-Miller SP, Mori Y, Rahman MM, McFadden G, Johnston RN. The viral tropism of two distinct oncolytic viruses, reovirus and myxoma virus, is modulated by cellular tumor suppressor gene status. Oncogene. 29: 3990-6. PMID 20473328 DOI: 10.1038/Onc.2010.137  0.439
2010 Smallwood SE, Rahman MM, Smith DW, McFadden G. Myxoma virus: propagation, purification, quantification, and storage. Current Protocols in Microbiology. Unit 14A.1. PMID 20440681 DOI: 10.1002/9780471729259.Mc14A01S17  0.436
2010 Villa NY, Bartee E, Mohamed MR, Rahman MM, Barrett JW, McFadden G. Myxoma and vaccinia viruses exploit different mechanisms to enter and infect human cancer cells. Virology. 401: 266-79. PMID 20334889 DOI: 10.1016/J.Virol.2010.02.027  0.37
2010 Rahman MM, Madlambayan GJ, Cogle CR, McFadden G. Oncolytic viral purging of leukemic hematopoietic stem and progenitor cells with Myxoma virus. Cytokine & Growth Factor Reviews. 21: 169-75. PMID 20211576 DOI: 10.1016/J.Cytogfr.2010.02.010  0.33
2010 McFadden G. Killing a killer: what next for smallpox? Plos Pathogens. 6: e1000727. PMID 20126444 DOI: 10.1371/Journal.Ppat.1000727  0.371
2010 Werden SJ, McFadden G. Pharmacological manipulation of the akt signaling pathway regulates myxoma virus replication and tropism in human cancer cells. Journal of Virology. 84: 3287-302. PMID 20106927 DOI: 10.1128/Jvi.02020-09  0.413
2010 Lun X, Alain T, Zemp FJ, Zhou H, Rahman MM, Hamilton MG, McFadden G, Bell J, Senger DL, Forsyth PA. Myxoma virus virotherapy for glioma in immunocompetent animal models: optimizing administration routes and synergy with rapamycin. Cancer Research. 70: 598-608. PMID 20068158 DOI: 10.1158/0008-5472.Can-09-1510  0.34
2010 Josiah DT, Zhu D, Dreher F, Olson J, McFadden G, Caldas H. Adipose-derived stem cells as therapeutic delivery vehicles of an oncolytic virus for glioblastoma. Molecular Therapy : the Journal of the American Society of Gene Therapy. 18: 377-85. PMID 19904233 DOI: 10.1038/Mt.2009.265  0.434
2010 Lun X, Forsyth PA, Senger DL, Robbins S, Kelly JJp, Weiss S, Bell J, McFadden G. Abstract 4283: Myxoma virotherapy targeting temozolomide-resistant brain tumor initiating cellsin vitroandin vivo Cancer Research. 70: 4283-4283. DOI: 10.1158/1538-7445.Am10-4283  0.316
2009 Lucas A, Liu L, Dai E, Bot I, Viswanathan K, Munuswamy-Ramunujam G, Davids JA, Bartee MY, Richardson J, Christov A, Wang H, Macaulay C, Poznansky M, Zhong R, Miller L, ... ... McFadden G, et al. The serpin saga; development of a new class of virus derived anti-inflammatory protein immunotherapeutics. Advances in Experimental Medicine and Biology. 666: 132-56. PMID 20054981 DOI: 10.1007/978-1-4419-1601-3_11  0.446
2009 Rahman MM, Lucas AR, McFadden G. Viral TNF inhibitors as potential therapeutics. Advances in Experimental Medicine and Biology. 666: 64-77. PMID 20054975 DOI: 10.1007/978-1-4419-1601-3_5  0.36
2009 Van Vliet K, Mohamed MR, Zhang L, Villa NY, Werden SJ, Liu J, McFadden G. Poxvirus proteomics and virus-host protein interactions. Microbiology and Molecular Biology Reviews : Mmbr. 73: 730-49. PMID 19946139 DOI: 10.1128/Mmbr.00026-09  0.433
2009 Kim M, Madlambayan GJ, Rahman MM, Smallwood SE, Meacham AM, Hosaka K, Scott EW, Cogle CR, McFadden G. Myxoma virus targets primary human leukemic stem and progenitor cells while sparing normal hematopoietic stem and progenitor cells Leukemia. 23: 2313-2317. PMID 19865109 DOI: 10.1038/leu.2009.219  0.332
2009 Rahman MM, Mohamed MR, Kim M, Smallwood S, McFadden G. Co-regulation of NF-kappaB and inflammasome-mediated inflammatory responses by myxoma virus pyrin domain-containing protein M013. Plos Pathogens. 5: e1000635. PMID 19851467 DOI: 10.1371/Journal.Ppat.1000635  0.42
2009 Werden SJ, Lanchbury J, Shattuck D, Neff C, Dufford M, McFadden G. The myxoma virus m-t5 ankyrin repeat host range protein is a novel adaptor that coordinately links the cellular signaling pathways mediated by Akt and Skp1 in virus-infected cells. Journal of Virology. 83: 12068-83. PMID 19776120 DOI: 10.1128/Jvi.00963-09  0.431
2009 Mohamed MR, McFadden G. NFkB inhibitors: strategies from poxviruses. Cell Cycle (Georgetown, Tex.). 8: 3125-32. PMID 19738427 DOI: 10.4161/Cc.8.19.9683  0.361
2009 McFadden G, Mohamed MR, Rahman MM, Bartee E. Cytokine determinants of viral tropism. Nature Reviews. Immunology. 9: 645-55. PMID 19696766 DOI: 10.1038/Nri2623  0.468
2009 Bartee E, McFadden G. Human cancer cells have specifically lost the ability to induce the synergistic state caused by tumor necrosis factor plus interferon-beta. Cytokine. 47: 199-205. PMID 19640730 DOI: 10.1016/J.Cyto.2009.06.006  0.375
2009 Zhang L, Villa NY, Rahman MM, Smallwood S, Shattuck D, Neff C, Dufford M, Lanchbury JS, Labaer J, McFadden G. Analysis of vaccinia virus-host protein-protein interactions: validations of yeast two-hybrid screenings. Journal of Proteome Research. 8: 4311-8. PMID 19637933 DOI: 10.1021/Pr900491N  0.45
2009 Mohamed MR, Rahman MM, Rice A, Moyer RW, Werden SJ, McFadden G. Cowpox virus expresses a novel ankyrin repeat NF-kappaB inhibitor that controls inflammatory cell influx into virus-infected tissues and is critical for virus pathogenesis. Journal of Virology. 83: 9223-36. PMID 19570875 DOI: 10.1128/Jvi.00861-09  0.438
2009 Zhang L, Stanford M, Liu J, Barrett C, Jiang L, Barclay AN, McFadden G. Inhibition of macrophage activation by the myxoma virus M141 protein (vCD200). Journal of Virology. 83: 9602-7. PMID 19570854 DOI: 10.1128/Jvi.01078-09  0.423
2009 Barrett JW, Werden SJ, Wang F, McKillop WM, Jimenez J, Villeneuve D, McFadden G, Dekaban GA. Myxoma virus M130R is a novel virulence factor required for lethal myxomatosis in rabbits. Virus Research. 144: 258-65. PMID 19477207 DOI: 10.1016/J.Virusres.2009.05.009  0.484
2009 Mohamed MR, Rahman MM, Lanchbury JS, Shattuck D, Neff C, Dufford M, van Buuren N, Fagan K, Barry M, Smith S, Damon I, McFadden G. Proteomic screening of variola virus reveals a unique NF-kappaB inhibitor that is highly conserved among pathogenic orthopoxviruses. Proceedings of the National Academy of Sciences of the United States of America. 106: 9045-50. PMID 19451633 DOI: 10.1073/Pnas.0900452106  0.43
2009 Bartee MY, Dai E, Liu L, Munuswamy-Ramanujam G, Macaulay C, McIvor D, McFadden G, Lucas AR. 10 M-T7: measuring chemokine-modulating activity. Methods in Enzymology. 460: 209-28. PMID 19446727 DOI: 10.1016/S0076-6879(09)05210-0  0.37
2009 Wang F, Barrett JW, Ma Y, Dekaban GA, McFadden G. Induction of alpha/beta interferon by myxoma virus is selectively abrogated when primary mouse embryo fibroblasts become immortalized. Journal of Virology. 83: 5928-32. PMID 19297474 DOI: 10.1128/Jvi.02587-08  0.442
2009 Liu J, Wennier S, Reinhard M, Roy E, MacNeill A, McFadden G. Myxoma virus expressing interleukin-15 fails to cause lethal myxomatosis in European rabbits Journal of Virology. 83: 5933-5938. PMID 19279088 DOI: 10.1128/Jvi.00204-09  0.345
2009 Wang F, Barrett JW, Shao Q, Gao X, Dekaban GA, McFadden G. Myxoma virus selectively disrupts type I interferon signaling in primary human fibroblasts by blocking the activation of the Janus kinase Tyk2. Virology. 387: 136-46. PMID 19254804 DOI: 10.1016/J.Virol.2009.02.013  0.405
2009 Rahman MM, Jeng D, Singh R, Coughlin J, Essani K, McFadden G. Interaction of human TNF and beta2-microglobulin with Tanapox virus-encoded TNF inhibitor, TPV-2L. Virology. 386: 462-8. PMID 19232662 DOI: 10.1016/J.Virol.2009.01.026  0.339
2009 Zhang L, Villa NY, McFadden G. Interplay between poxviruses and the cellular ubiquitin/ubiquitin-like pathways. Febs Letters. 583: 607-14. PMID 19174161 DOI: 10.1016/J.Febslet.2009.01.023  0.367
2009 Bartee E, Mohamed MR, Lopez MC, Baker HV, McFadden G. The addition of tumor necrosis factor plus beta interferon induces a novel synergistic antiviral state against poxviruses in primary human fibroblasts. Journal of Virology. 83: 498-511. PMID 18971273 DOI: 10.1128/Jvi.01376-08  0.447
2008 Moussatché N, Damaso CR, McFadden G. When good vaccines go wild: Feral Orthopoxvirus in developing countries and beyond Journal of Infection in Developing Countries. 2: 156-173. PMID 19738346 DOI: 10.3855/Jidc.258  0.412
2008 Li X, Schneider H, Peters A, Macaulay C, King E, Sun Y, Liu L, Dai E, Davids JA, McFadden G, Lucas A. Heparin alters viral serpin, serp-1, anti-thrombolytic activity to anti-thrombotic activity. The Open Biochemistry Journal. 2: 6-15. PMID 18949070 DOI: 10.2174/1874091X00802010006  0.323
2008 Adams MM, van Leeuwen BH, McFadden G, Kerr PJ. Construction and testing of a novel host-range defective myxoma virus vaccine with the M063 gene inactivated that is non-permissive for replication in rabbit cells. Veterinary Research. 39: 60. PMID 18778680 DOI: 10.1051/Vetres:2008037  0.393
2008 Wang F, Gao X, Barrett JW, Shao Q, Bartee E, Mohamed MR, Rahman M, Werden S, Irvine T, Cao J, Dekaban GA, McFadden G. RIG-I mediates the co-induction of tumor necrosis factor and type I interferon elicited by myxoma virus in primary human macrophages. Plos Pathogens. 4: e1000099. PMID 18617992 DOI: 10.1371/Journal.Ppat.1000099  0.467
2008 Bartee E, Mohamed MR, McFadden G. Tumor necrosis factor and interferon: cytokines in harmony. Current Opinion in Microbiology. 11: 378-83. PMID 18595771 DOI: 10.1016/J.Mib.2008.05.015  0.37
2008 Werden SJ, Rahman MM, McFadden G. Poxvirus host range genes. Advances in Virus Research. 71: 135-71. PMID 18585528 DOI: 10.1016/S0065-3527(08)00003-1  0.472
2008 Woo Y, Kelly KJ, Stanford MM, Galanis C, Chun YS, Fong Y, McFadden G. Myxoma virus is oncolytic for human pancreatic adenocarcinoma cells. Annals of Surgical Oncology. 15: 2329-35. PMID 18454298 DOI: 10.1245/S10434-008-9924-Z  0.398
2008 Wu Y, Lun X, Zhou H, Wang L, Sun B, Bell JC, Barrett JW, McFadden G, Biegel JA, Senger DL, Forsyth PA. Oncolytic efficacy of recombinant vesicular stomatitis virus and myxoma virus in experimental models of rhabdoid tumors. Clinical Cancer Research : An Official Journal of the American Association For Cancer Research. 14: 1218-27. PMID 18281557 DOI: 10.1158/1078-0432.Ccr-07-1330  0.417
2008 Stanford MM, Shaban M, Barrett JW, Werden SJ, Gilbert PA, Bondy-Denomy J, Mackenzie L, Graham KC, Chambers AF, McFadden G. Myxoma virus oncolysis of primary and metastatic B16F10 mouse tumors in vivo. Molecular Therapy : the Journal of the American Society of Gene Therapy. 16: 52-9. PMID 17998900 DOI: 10.1038/Sj.Mt.6300348  0.363
2008 Jiang J, Arp J, Kubelik D, Zassoko R, Liu W, Wise Y, Macaulay C, Garcia B, McFadden G, Lucas AR, Wang H. Induction of indefinite cardiac allograft survival correlates with toll-like receptor 2 and 4 downregulation after serine protease inhibitor-1 (Serp-1) treatment. Transplantation. 84: 1158-67. PMID 17998872 DOI: 10.1097/01.Tp.0000286099.50532.B0  0.322
2008 Nazarian SH, Rahman MM, Werden SJ, Villeneuve D, Meng X, Brunetti C, Valeriano C, Wong C, Singh R, Barrett JW, Xiang Y, McFadden G. Yaba monkey tumor virus encodes a functional inhibitor of interleukin-18. Journal of Virology. 82: 522-8. PMID 17959666 DOI: 10.1128/Jvi.00688-07  0.311
2008 Werden SJ, McFadden G. The role of cell signaling in poxvirus tropism: The case of the M-T5 host range protein of myxoma virus Biochimica Et Biophysica Acta - Proteins and Proteomics. 1784: 228-237. PMID 17905673 DOI: 10.1016/J.Bbapap.2007.08.001  0.483
2008 McFadden G. PL-17 Poxvirus immune evasion and host tropism are linked by cytokines Cytokine. 43: 302-303. DOI: 10.1016/J.Cyto.2008.07.331  0.326
2008 Barrett JW, McFadden G. Origin and Evolution of Poxviruses Origin and Evolution of Viruses. 431-446. DOI: 10.1016/B978-0-12-374153-0.00019-9  0.318
2007 Barrett JW, Alston LR, Wang F, Stanford MM, Gilbert PA, Gao X, Jimenez J, Villeneuve D, Forsyth P, McFadden G. Identification of host range mutants of myxoma virus with altered oncolytic potential in human glioma cells. Journal of Neurovirology. 13: 549-60. PMID 18097886 DOI: 10.1080/13550280701591526  0.507
2007 Rahman MM, McFadden G. BAFfled by Poxviruses? Cell Host and Microbe. 1: 159-160. PMID 18005693 DOI: 10.1016/J.Chom.2007.05.002  0.458
2007 Lun XQ, Zhou H, Alain T, Sun B, Wang L, Barrett JW, Stanford MM, McFadden G, Bell J, Senger DL, Forsyth PA. Targeting human medulloblastoma: oncolytic virotherapy with myxoma virus is enhanced by rapamycin. Cancer Research. 67: 8818-27. PMID 17875723 DOI: 10.1158/0008-5472.Can-07-1214  0.442
2007 Stanford MM, Barrett JW, Gilbert PA, Bankert R, McFadden G. Myxoma virus expressing human interleukin-12 does not induce myxomatosis in European rabbits. Journal of Virology. 81: 12704-8. PMID 17728229 DOI: 10.1128/Jvi.01483-07  0.465
2007 Stanford MM, McFadden G. Myxoma virus and oncolytic virotherapy: A new biologic weapon in the war against cancer Expert Opinion On Biological Therapy. 7: 1415-1425. PMID 17727330 DOI: 10.1517/14712598.7.9.1415  0.438
2007 Johnston JB, Rahman MM, McFadden G. Strategies that modulate inflammasomes: insights from host-pathogen interactions. Seminars in Immunopathology. 29: 261-74. PMID 17717669 DOI: 10.1007/S00281-007-0080-5  0.356
2007 Nazarian SH, Barrett JW, Stanford MM, Johnston JB, Essani K, McFadden G. Tropism of Tanapox virus infection in primary human cells. Virology. 368: 32-40. PMID 17632198 DOI: 10.1016/J.Virol.2007.06.019  0.443
2007 Nazarian SH, Barrett JW, Frace AM, Olsen-Rasmussen M, Khristova M, Shaban M, Neering S, Li Y, Damon IK, Esposito JJ, Essani K, McFadden G. Comparative genetic analysis of genomic DNA sequences of two human isolates of Tanapox virus. Virus Research. 129: 11-25. PMID 17574698 DOI: 10.1016/J.Virusres.2007.05.001  0.379
2007 Douglas AE, Corbett KD, Berger JM, McFadden G, Handel TM. Structure of M11L: A myxoma virus structural homolog of the apoptosis inhibitor, Bcl-2. Protein Science : a Publication of the Protein Society. 16: 695-703. PMID 17384234 DOI: 10.1110/Ps.062720107  0.416
2007 Stanford MM, Werden SJ, McFadden G. Myxoma virus in the European rabbit: Interactions between the virus and its susceptible host Veterinary Research. 38: 299-318. PMID 17296158 DOI: 10.1051/Vetres:2006054  0.474
2007 Stanford MM, McFadden G, Karupiah G, Chaudhri G. Immunopathogenesis of poxvirus infections: Forecasting the impending storm Immunology and Cell Biology. 85: 93-102. PMID 17228320 DOI: 10.1038/Sj.Icb.7100033  0.472
2007 Barrett JW, Chang CS, Wang G, Werden SJ, Shao Z, Barrett C, Gao X, Belsito TA, Villenevue D, McFadden G. Myxoma virus M063R is a host range gene essential for virus replication in rabbit cells Virology. 361: 123-132. PMID 17184804 DOI: 10.1016/J.Virol.2006.11.015  0.486
2007 Werden SJ, Barrett JW, Wang G, Stanford MM, McFadden G. M-T5, the ankyrin repeat, host range protein of myxoma virus, activates Akt and can be functionally replaced by cellular PIKE-A. Journal of Virology. 81: 2340-8. PMID 17151107 DOI: 10.1128/Jvi.01310-06  0.423
2007 Stanford MM, Barrett JW, Nazarian SH, Werden S, McFadden G. Oncolytic virotherapy synergism with signaling inhibitors: Rapamycin increases myxoma virus tropism for human tumor cells Journal of Virology. 81: 1251-1260. PMID 17108021 DOI: 10.1128/Jvi.01408-06  0.461
2007 Barrett JW, Sypula J, Wang F, Alston LR, Shao Z, Gao X, Irvine TS, McFadden G. M135R is a novel cell surface virulence factor of myxoma virus. Journal of Virology. 81: 106-14. PMID 17065210 DOI: 10.1128/Jvi.01633-06  0.352
2006 Gilbert PA, McFadden G. Poxvirus cancer therapy. Recent Patents On Anti-Infective Drug Discovery. 1: 309-21. PMID 18221156 DOI: 10.2174/157489106778777592  0.368
2006 Sedger LM, Osvath SR, Xu XM, Li G, Chan FK, Barrett JW, McFadden G. Poxvirus tumor necrosis factor receptor (TNFR)-like T2 proteins contain a conserved preligand assembly domain that inhibits cellular TNFR1-induced cell death. Journal of Virology. 80: 9300-9. PMID 16940541 DOI: 10.1128/Jvi.02449-05  0.441
2006 Barrett JW, Sun Y, Nazarian SH, Belsito TA, Brunetti CR, McFadden G. Optimization of codon usage of poxvirus genes allows for improved transient expression in mammalian cells. Virus Genes. 33: 15-26. PMID 16791414 DOI: 10.1007/S11262-005-0035-7  0.312
2006 Rahman MM, Barrett JW, Brouckaert P, McFadden G. Variation in Ligand Binding Specificities of a Novel Class of Poxvirus-encoded Tumor Necrosis Factor-binding Protein Journal of Biological Chemistry. 281: 22517-22526. PMID 16782702 DOI: 10.1074/Jbc.M604645200  0.363
2006 Wang G, Barrett JW, Stanford M, Werden SJ, Johnston JB, Gao X, Sun M, Cheng JQ, McFadden G. Infection of human cancer cells with myxoma virus requires Akt activation via interaction with a viral ankyrin-repeat host range factor. Proceedings of the National Academy of Sciences of the United States of America. 103: 4640-5. PMID 16537421 DOI: 10.1073/Pnas.0509341103  0.456
2006 Rahman MM, McFadden G. Modulation of tumor necrosis factor by microbial pathogens Plos Pathogens. 2. PMID 16518473 DOI: 10.1371/Journal.Ppat.0020004  0.378
2006 Finlay BB, McFadden G. Anti-immunology: Evasion of the host immune system by bacterial and viral pathogens Cell. 124: 767-782. PMID 16497587 DOI: 10.1016/J.Cell.2006.01.034  0.372
2006 Su J, Wang G, Barrett JW, Irvine TS, Gao X, McFadden G. Myxoma virus M11L blocks apoptosis through inhibition of conformational activation of Bax at the mitochondria. Journal of Virology. 80: 1140-51. PMID 16414991 DOI: 10.1128/Jvi.80.3.1140-1151.2006  0.405
2006 Dai E, Viswanathan K, Sun YM, Li X, Liu LY, Togonu-Bickersteth B, Richardson J, Macaulay C, Nash P, Turner P, Nazarian SH, Moyer R, McFadden G, Lucas AR. Identification of myxomaviral serpin reactive site loop sequences that regulate innate immune responses. The Journal of Biological Chemistry. 281: 8041-50. PMID 16407226 DOI: 10.1074/Jbc.M509454200  0.329
2006 McFadden G, Nazarian SH. Immune evasion by poxviruses Future Virology. 1: 123-132. DOI: 10.2217/17460794.1.1.123  0.431
2005 Gilbert PA, Comanita L, Barrett J, Peters A, Szabat M, McFadden G, Dekaban GA. Current Status for High Titre Poxvirus Stock Preparation in CEF Under Serum-Free Medium Conditions: Implication for Vaccine Development. Cytotechnology. 48: 79-88. PMID 19003034 DOI: 10.1007/S10616-005-3795-Y  0.349
2005 Johnston JB, Barrett JW, Nazarian SH, Goodwin M, Ricciuto D, Ricuttio D, Wang G, McFadden G. A poxvirus-encoded pyrin domain protein interacts with ASC-1 to inhibit host inflammatory and apoptotic responses to infection. Immunity. 23: 587-98. PMID 16356857 DOI: 10.1016/J.Immuni.2005.10.003  0.441
2005 Gao M, Brufatto N, Chen T, Murley LL, Thalakada R, Domagala M, Beattie B, Mamelak D, Athanasopoulos V, Johnson D, McFadden G, Burks C, Frappier L. Expression profiling of herpesvirus and vaccinia virus proteins using a high-throughput baculovirus screening system. Journal of Proteome Research. 4: 2225-35. PMID 16335970 DOI: 10.1021/Pr050137U  0.392
2005 Lun X, Yang W, Alain T, Shi ZQ, Muzik H, Barrett JW, McFadden G, Bell J, Hamilton MG, Senger DL, Forsyth PA. Myxoma virus is a novel oncolytic virus with significant antitumor activity against experimental human gliomas. Cancer Research. 65: 9982-90. PMID 16267023 DOI: 10.1158/0008-5472.Can-05-1201  0.484
2005 Johnston JB, Wang G, Barrett JW, Nazarian SH, Colwill K, Moran M, McFadden G. Myxoma virus M-T5 protects infected cells from the stress of cell cycle arrest through its interaction with host cell cullin-1. Journal of Virology. 79: 10750-63. PMID 16051867 DOI: 10.1128/Jvi.79.16.10750-10763.2005  0.399
2005 Stanford MM, McFadden G. The 'supervirus'? Lessons from IL-4-expressing poxviruses Trends in Immunology. 26: 339-345. PMID 15922951 DOI: 10.1016/J.It.2005.04.001  0.398
2005 Cameron CM, Barrett JW, Mann M, Lucas A, McFadden G. Myxoma virus M128L is expressed as a cell surface CD47-like virulence factor that contributes to the downregulation of macrophage activation in vivo. Virology. 337: 55-67. PMID 15914220 DOI: 10.1016/J.Virol.2005.03.037  0.48
2005 Cameron CM, Barrett JW, Liu L, Lucas AR, McFadden G. Myxoma virus M141R expresses a viral CD200 (vOX-2) that is responsible for down-regulation of macrophage and T-cell activation in vivo. Journal of Virology. 79: 6052-67. PMID 15857991 DOI: 10.1128/Jvi.79.10.6052-6067.2005  0.479
2005 McFadden G. Poxvirus tropism Nature Reviews Microbiology. 3: 201-213. PMID 15738948 DOI: 10.1038/nrmicro1099  0.341
2005 Johnston JB, Nazarian SH, Natale R, McFadden G. Myxoma virus infection of primary human fibroblasts varies with cellular age and is regulated by host interferon responses. Virology. 332: 235-48. PMID 15661156 DOI: 10.1016/J.Virol.2004.11.030  0.465
2004 Wang F, Ma Y, Barrett JW, Gao X, Loh J, Barton E, Virgin HW, McFadden G. Disruption of Erk-dependent type I interferon induction breaks the myxoma virus species barrier Nature Immunology. 5: 1266-1274. PMID 15502830 DOI: 10.1038/Ni1132  0.377
2004 McFadden G. Smallpox: An ancient disease enters the modern era of virogenomics Proceedings of the National Academy of Sciences of the United States of America. 101: 14994-14995. PMID 15479762 DOI: 10.1073/Pnas.0406207101  0.403
2004 Lucas A, McFadden G. Secreted immunomodulatory viral proteins as novel biotherapeutics Journal of Immunology. 173: 4765-4774. PMID 15470015 DOI: 10.4049/Jimmunol.173.8.4765  0.426
2004 Johnston JB, McFadden G. Technical knockout: understanding poxvirus pathogenesis by selectively deleting viral immunomodulatory genes. Cellular Microbiology. 6: 695-705. PMID 15236637 DOI: 10.1111/J.1462-5822.2004.00423.X  0.44
2004 Liu L, Dai E, Miller L, Seet B, Lalani A, Macauley C, Li X, Virgin HW, Bunce C, Turner P, Moyer R, McFadden G, Lucas A. Viral chemokine-binding proteins inhibit inflammatory responses and aortic allograft transplant vasculopathy in rat models. Transplantation. 77: 1652-1660. PMID 15201663 DOI: 10.1097/01.Tp.0000131173.52424.84  0.343
2004 Wang G, Barrett JW, Nazarian SH, Everett H, Gao X, Bleackley C, Colwill K, Moran MF, McFadden G. Myxoma virus M11L prevents apoptosis through constitutive interaction with Bak. Journal of Virology. 78: 7097-111. PMID 15194786 DOI: 10.1128/Jvi.78.13.7097-7111.2004  0.704
2004 Seet BT, McFadden G. Interaction analysis of viral cytokine-binding proteins using surface plasmon resonance Methods in Molecular Biology (Clifton, N.J.). 269: 219-242. PMID 15114019 DOI: 10.1385/1-59259-789-0:219  0.405
2004 Liu L, Viswanathan K, Dai E, Turner PC, Togonu-Bickersteth J, Pang B, Li Y, Moyer RW, McFadden G, Lucas A. 803-4 Analysis of anti-apoptotic intracellular viral serpins as anti-atherosclerotic agents Journal of the American College of Cardiology. 43. DOI: 10.1016/S0735-1097(04)90227-6  0.308
2004 Lucas A, Viswanathan K, Togonu-Bickersteth B, Liu Ly, Dai E, Sun Ym, Turner P, Moyer R, McFadden G. Regulation Of Vascular Innate Immune Responses By Viral And Mammalian Serpins Cardiovascular Pathology. 13: 113. DOI: 10.1016/J.Carpath.2004.03.340  0.346
2003 Seet BT, McCaughan CA, Handel TM, Mercer A, Brunetti C, McFadden G, Fleming SB. Analysis of an orf virus chemokine-binding protein: Shifting ligand specificities among a family of poxvirus viroceptors. Proceedings of the National Academy of Sciences of the United States of America. 100: 15137-42. PMID 14657392 DOI: 10.1073/Pnas.2336648100  0.349
2003 Brunetti CR, Amano H, Ueda Y, Qin J, Miyamura T, Suzuki T, Li X, Barrett JW, McFadden G. Complete genomic sequence and comparative analysis of the tumorigenic poxvirus Yaba monkey tumor virus. Journal of Virology. 77: 13335-47. PMID 14645589 DOI: 10.1128/Jvi.77.24.13335-13347.2003  0.411
2003 Johnston JB, McFadden G. Poxvirus immunomodulatory strategies: current perspectives. Journal of Virology. 77: 6093-100. PMID 12743266 DOI: 10.1128/Jvi.77.11.6093-6100.2003  0.497
2003 Johnston JB, Barrett JW, Chang W, Chung CS, Zeng W, Masters J, Mann M, Wang F, Cao J, McFadden G. Role of the serine-threonine kinase PAK-1 in myxoma virus replication. Journal of Virology. 77: 5877-88. PMID 12719581 DOI: 10.1128/Jvi.77.10.5877-5888.2003  0.455
2003 Brunetti CR, Paulose-Murphy M, Singh R, Qin J, Barrett JW, Tardivel A, Schneider P, Essani K, McFadden G. A secreted high-affinity inhibitor of human TNF from Tanapox virus. Proceedings of the National Academy of Sciences of the United States of America. 100: 4831-6. PMID 12676996 DOI: 10.1073/Pnas.0737244100  0.396
2003 Dai E, Guan H, Liu L, Little SH, McFadden G, Vaziri S, Cao H, Ivanova IA, Bocksch L, Lucas A. Serp-1, a viral anti-inflammatory serpin, regulates cellular serine proteinase and serpin responses to vascular injury. Journal of Biological Chemistry. 278: 18563-18572. PMID 12637546 DOI: 10.1074/Jbc.M209683200  0.366
2003 Seet BT, Johnston JB, Brunetti CR, Barrett JW, Everett H, Cameron C, Sypula J, Nazarian SH, Lucas A, McFadden G. Poxviruses and immune evasion. Annual Review of Immunology. 21: 377-423. PMID 12543935 DOI: 10.1146/Annurev.Immunol.21.120601.141049  0.698
2003 Mansouri M, Bartee E, Gouveia K, Hovey Nerenberg BT, Barrett J, Thomas L, Thomas G, McFadden G, Früh K. The PHD/LAP-domain protein M153R of myxomavirus is a ubiquitin ligase that induces the rapid internalization and lysosomal destruction of CD4. Journal of Virology. 77: 1427-40. PMID 12502858 DOI: 10.1128/Jvi.77.2.1427-1440.2003  0.318
2002 Everett H, Barry M, Sun X, Lee SF, Frantz C, Berthiaume LG, McFadden G, Bleackley RC. The myxoma poxvirus protein, M11L, prevents apoptosis by direct interaction with the mitochondrial permeability transition pore. The Journal of Experimental Medicine. 196: 1127-39. PMID 12417624 DOI: 10.1084/Jem.20011247  0.657
2002 Everett H, McFadden G. Poxviruses and apoptosis: A time to die Current Opinion in Microbiology. 5: 395-402. PMID 12160859 DOI: 10.1016/S1369-5274(02)00340-5  0.666
2002 Seet BT, McFadden G. Viral chemokine-binding proteins Journal of Leukocyte Biology. 72: 24-34. PMID 12101259 DOI: 10.1189/Jlb.72.1.24  0.421
2002 Smith GL, McFadden G. Smallpox: Anything to declare? Nature Reviews Immunology. 2: 521-527. PMID 12094226 DOI: 10.1038/Nri845  0.358
2002 Kerr P, McFadden G. Immune responses to myxoma virus Viral Immunology. 15: 229-246. PMID 12081009 DOI: 10.1089/08828240260066198  0.493
2002 Cao JX, Teoh ML, Moon M, McFadden G, Evans DH. Leporipoxvirus Cu-Zn superoxide dismutase homologs inhibit cellular superoxide dismutase, but are not essential for virus replication or virulence. Virology. 296: 125-35. PMID 12036324 DOI: 10.1006/Viro.2002.1383  0.352
2001 Cao JX, Mcfadden G. Characterization of the myxoma virus M118L protein: A novel essential poxvirus IMV-associated protein Virus Genes. 23: 303-313. PMID 11778698 DOI: 10.1023/A:1012573306916  0.415
2001 Masters J, Hinek AA, Uddin S, Platanias LC, Zeng W, McFadden G, Fish EN. Poxvirus infection rapidly activates tyrosine kinase signal transduction. The Journal of Biological Chemistry. 276: 48371-5. PMID 11591716 DOI: 10.1074/Jbc.M108019200  0.488
2001 Everett H, McFadden G. Viruses and apoptosis: Meddling with mitochondria Virology. 288: 1-7. PMID 11543652 DOI: 10.1006/Viro.2001.1081  0.732
2001 Seet BT, Singh R, Paavola C, Lau EK, Handel TM, McFadden G. Molecular determinants for CC-chemokine recognition by a poxvirus CC-chemokine inhibitor. Proceedings of the National Academy of Sciences of the United States of America. 98: 9008-13. PMID 11470923 DOI: 10.1073/Pnas.171069398  0.344
2001 Seet BT, Barrett J, Robichaud J, Shilton B, Singh R, McFadden G. Glycosaminoglycan Binding Properties of the Myxoma Virus CC-chemokine Inhibitor, M-T1 Journal of Biological Chemistry. 276: 30504-30513. PMID 11369757 DOI: 10.1074/Jbc.M011401200  0.379
2001 Everett H, McFadden G. Viral proteins and the mitochondrial apoptotic checkpoint Cytokine and Growth Factor Reviews. 12: 181-188. PMID 11325601 DOI: 10.1016/S1359-6101(00)00025-3  0.691
2001 Barrett JW, Cao J, Hota-Mitchell S, McFadden G. Immunomodulatory proteins of myxoma virus. Seminars in Immunology. 13: 73-84. PMID 11289802 DOI: 10.1006/Smim.2000.0298  0.412
2001 Nash P, Barry M, Seet BT, Veugelers K, Hota S, Heger J, Hodgkinson C, Graham K, Jackson RJ, McFadden G. Post-translational modification of the myxoma-virus anti-inflammatory serpin SERP-1 by a virally encoded sialyltransferase. The Biochemical Journal. 347: 375-82. PMID 10749666 DOI: 10.1042/0264-6021:3470375  0.481
2000 Xu X, Nash P, McFadden G. Myxoma virus expresses a TNF receptor homolog with two distinct functions Virus Genes. 21: 97-109. PMID 11022793  0.33
2000 McFadden G, Murphy PM. Host-related immunomodulators encoded by poxviruses and herpesviruses Current Opinion in Microbiology. 3: 371-378. PMID 10972497 DOI: 10.1016/S1369-5274(00)00107-7  0.438
2000 Van Berkel V, Barrett J, Tiffany HL, Fremont DH, Murphy PM, Mcfadden G, Speck SH, Virgin IV HW. Identification of a gammaherpesvirus selective chemokine binding protein that inhibits chemokine action Journal of Virology. 74: 6741-6747. PMID 10888612 DOI: 10.1128/Jvi.74.15.6741-6747.2000  0.382
2000 Liu L, Lalani A, Dai E, Seet B, Macauley C, Singh R, Fan L, McFadden G, Lucas A. The viral anti-inflammatory chemokine-binding protein M-T7 reduces intimal hyperplasia after vascular injury. Journal of Clinical Investigation. 105: 1613-1621. PMID 10841520 DOI: 10.1172/Jci8934  0.354
2000 Everett H, Barry M, Lee SF, Sun X, Graham K, Stone J, Bleackley RC, McFadden G. M11L: a novel mitochondria-localized protein of myxoma virus that blocks apoptosis of infected leukocytes. The Journal of Experimental Medicine. 191: 1487-98. PMID 10790424 DOI: 10.1084/Jem.191.9.1487  0.738
2000 Miller LW, Dai E, Nash P, Liu L, Icton C, Klironomos D, Fan L, Nation PN, Zhong R, McFadden G, Lucas A. Inhibition of transplant vasculopathy in a rat aortic allograft model after infusion of anti-inflammatory viral serpin. Circulation. 101: 1598-605. PMID 10747355 DOI: 10.1161/01.Cir.101.13.1598  0.363
2000 Lalani AS, Barrett JW, McFadden G. Modulating chemokines: More lessons from viruses Immunology Today. 21: 100-106. PMID 10652469 DOI: 10.1016/S0167-5699(99)01556-X  0.407
2000 Bedard ELR, Jiang J, Parry N, Garcia B, Lucas A, Li X, Acklin S, McFadden G, Zhong R. VIRAL PROTEINS: A NOVEL APPROACH TO PREVENTING CHRONIC REJECTION.: Abstract# 1143 Transplantation. 69. DOI: 10.1097/00007890-200004271-01143  0.324
2000 Xu X, Nash P, McFadden G. Virus Genes. 21: 97-109. DOI: 10.1023/A:1008136431036  0.425
1999 Lalani AS, McFadden G. Evasion and exploitation of chemokines by viruses Cytokine and Growth Factor Reviews. 10: 219-233. PMID 10647778 DOI: 10.1016/S1359-6101(99)00018-0  0.457
1999 Lalani AS, Masters J, Zeng W, Barrett J, Pannu R, Everett H, Arendt CW, McFadden G. Use of chemokine receptors by poxviruses. Science (New York, N.Y.). 286: 1968-71. PMID 10583963 DOI: 10.1126/Science.286.5446.1968  0.711
1999 Willer DO, McFadden G, Evans DH. The complete genome sequence of shope (rabbit) fibroma virus Virology. 264: 319-343. PMID 10562495 DOI: 10.1006/Viro.1999.0002  0.407
1999 Cameron C, Hota-Mitchell S, Chen L, Barrett J, Cao JX, Macaulay C, Willer D, Evans D, McFadden G. The complete dna sequence of myxoma virus Virology. 264: 298-318. PMID 10562494 DOI: 10.1006/Viro.1999.0001  0.45
1999 Hnatiuk S, Barry M, Zeng W, Liu L, Lucas A, Percy D, McFadden G. Role of the C-Terminal RDEL Motif of the Myxoma Virus M-T4 Protein in Terms of Apoptosis Regulation and Viral Pathogenesis Virology. 263: 290-306. PMID 10544103 DOI: 10.1006/Viro.1999.9946  0.391
1999 Zúñiga MC, Wang H, Barry M, McFadden G. Endosomal/lysosomal retention and degradation of major histocompatibility complex class I molecules is induced by myxoma virus. Virology. 261: 180-92. PMID 10497104 DOI: 10.1006/Viro.1999.9840  0.425
1999 Nash P, Barrett J, Jing-Xin C, Hota-Mitchell S, Lalani AS, Everett H, Xiao-Ming X, Robichaud J, Hnatiuk S, Ainslie C, Seet BT, McFadden G. Immunomodulation by viruses: The myxoma virus story Immunological Reviews. 168: 103-120. PMID 10399068 DOI: 10.1111/J.1600-065X.1999.Tb01286.X  0.754
1999 Everett H, McFadden G. Apoptosis: An innate immune response to virus infection Trends in Microbiology. 7: 160-165. PMID 10217831 DOI: 10.1016/S0966-842X(99)01487-0  0.736
1999 Lalani AS, Masters J, Graham K, Liu L, Lucas A, McFadden G. Role of the Myxoma Virus Soluble CC-Chemokine Inhibitor Glycoprotein, M-T1, during Myxoma Virus Pathogenesis Virology. 256: 233-245. PMID 10191189 DOI: 10.1006/Viro.1999.9617  0.474
1998 Lalani AS, Ness TL, Singh R, Harrison JK, Seet BT, Kelvin DJ, McFadden G, Moyer RW. Functional comparisons among members of the poxvirus T1/35kDa family of soluble CC-chemokine inhibitor glycoproteins. Virology. 250: 173-84. PMID 9770431 DOI: 10.1006/Viro.1998.9340  0.39
1998 Barry M, McFadden G. Apoptosis regulators from DNA viruses Current Opinion in Immunology. 10: 422-430. PMID 9722918 DOI: 10.1016/S0952-7915(98)80116-7  0.405
1998 Nash P, Whitty A, Handwerker J, Macen J, McFadden G. Inhibitory specificity of the anti-inflammatory myxoma virus serpin, SERP-1 Journal of Biological Chemistry. 273: 20982-20991. PMID 9694848 DOI: 10.1074/Jbc.273.33.20982  0.33
1998 McFadden G, Lalani A, Everett H, Nash P, Xu X. Virus-encoded receptors for cytokines and chemokines Seminars in Cell and Developmental Biology. 9: 359-368. PMID 9665873 DOI: 10.1006/Scdb.1998.0245  0.737
1998 McFadden G. Even viruses can learn to cope with stress Science. 279: 40. PMID 9441409 DOI: 10.1126/Science.279.5347.40  0.45
1998 Barry M, Hnatiuk S, Mossman K, Lee SF, Boshkov L, McFadden G. The myxoma virus M-T4 gene encodes a novel RDEL-containing protein that is retained within the endoplasmic reticulum and is important for the productive infection of lymphocytes. Virology. 239: 360-77. PMID 9434727 DOI: 10.1006/Viro.1997.8894  0.394
1998 McFadden G, Barry M. How poxviruses oppose apoptosis Seminars in Virology. 8: 429-442. DOI: 10.1006/Smvy.1997.0141  0.413
1997 Nash P, Lucas A, McFadden G. Serp-1, a poxvirus-encoded serpin, is expressed as a secreted glycoprotein that inhibits the inflammatory response to myxoma virus infection Advances in Experimental Medicine and Biology. 425: 195-205. PMID 9433502 DOI: 10.1007/978-1-4615-5391-5_19  0.5
1997 McFadden G, Kelvin D. New strategies for chemokine inhibition and modulation. You take the high road and I'll take the low road Biochemical Pharmacology. 54: 1271-1280. PMID 9393669 DOI: 10.1016/S0006-2952(97)00182-2  0.315
1997 Lalani AS, McFadden G. Secreted poxvirus chemokine binding proteins Journal of Leukocyte Biology. 62: 570-576. PMID 9365110 DOI: 10.1002/Jlb.62.5.570  0.43
1997 Lalani AS, Graham K, Mossman K, Rajarathnam K, Clark-Lewis I, Kelvin D, McFadden G. The purified myxoma virus gamma interferon receptor homolog M-T7 interacts with the heparin-binding domains of chemokines. Journal of Virology. 71: 4356-63. PMID 9151824 DOI: 10.1128/Jvi.71.6.4356-4363.1997  0.336
1997 Graham KA, Lalani AS, Macen JL, Ness TL, Barry M, Liu LY, Lucas A, Clark-Lewis I, Moyer RW, McFadden G. The T1/35kDa family of poxvirus-secreted proteins bind chemokines and modulate leukocyte influx into virus-infected tissues. Virology. 229: 12-24. PMID 9123853 DOI: 10.1006/Viro.1996.8423  0.503
1997 Schreiber M, Sedger L, Mcfadden G. Distinct domains of M-T2, the myxoma virus tumor necrosis factor (TNF) receptor homolog, mediate extracellular TNF binding and intracellular apoptosis inhibition Journal of Virology. 71: 2171-2181. PMID 9032351 DOI: 10.1128/Jvi.71.3.2171-2181.1997  0.422
1996 Sedger L, McFadden G. M-T2: A poxvirus TNF receptor homologue with dual activities Immunology and Cell Biology. 74: 538-545. PMID 8989592 DOI: 10.1038/Icb.1996.87  0.425
1996 Lucas A, Liu L, Macen J, Nash P, Dai E, Stewart M, Graham K, Etches W, Boshkov L, Nation PN, Humen D, Hobman ML, McFadden G. Virus-encoded serine proteinase inhibitor SERP-1 inhibits atherosclerotic plaque development after balloon angioplasty. Circulation. 94: 2890-900. PMID 8941118 DOI: 10.1161/01.Cir.94.11.2890  0.354
1996 Ellison KS, Peng W, McFadden G. Mutations in active-site residues of the uracil-DNA glycosylase encoded by vaccinia virus are incompatible with virus viability. Journal of Virology. 70: 7965-73. PMID 8892920 DOI: 10.1128/Jvi.70.11.7965-7973.1996  0.448
1996 Macen JL, Garner RS, Musy PY, Brooks MA, Turner PC, Moyer RW, McFadden G, Bleackley RC. Differential inhibition of the Fas- and granule-mediated cytolysis pathways by the orthopoxvirus cytokine response modifier A/SPI-2 and SPI-1 protein. Proceedings of the National Academy of Sciences of the United States of America. 93: 9108-13. PMID 8799162 DOI: 10.1073/Pnas.93.17.9108  0.452
1996 Mossman K, Lee SF, Barry M, Boshkov L, McFadden G. Disruption of M-T5, a novel myxoma virus gene member of poxvirus host range superfamily, results in dramatic attenuation of myxomatosis in infected European rabbits. Journal of Virology. 70: 4394-4410. PMID 8676463 DOI: 10.1128/Jvi.70.7.4394-4410.1996  0.469
1996 Schreiber M, Rajarathnam K, McFadden G. Myxoma virus T2 protein, a tumor necrosis factor (TNF) receptor homolog, is secreted as a monomer and dimer that each bind rabbit TNFα, but the dimer is a more potent TNF inhibitor Journal of Biological Chemistry. 271: 13333-13341. PMID 8662837 DOI: 10.1074/Jbc.271.23.13333  0.427
1996 Macen JL, Graham KA, Lee SF, Schreiber M, Boshkov LK, McFadden G. Expression of the myxoma virus tumor necrosis factor receptor homologue and M11L genes is required to prevent virus-induced apoptosis in infected rabbit T lymphocytes Virology. 218: 232-237. PMID 8615027 DOI: 10.1006/Viro.1996.0183  0.504
1996 Mossman K, Nation P, Macen J, Garbutt M, Lucas A, McFadden G. Myxoma virus M-T7, a secreted homolog of the interferon-gamma receptor, is a critical virulence factor for the development of myxomatosis in European rabbits. Virology. 215: 17-30. PMID 8553583 DOI: 10.1006/Viro.1996.0003  0.498
1995 Mossman K, Upton C, McFadden G. The myxoma virus-soluble interferon-γ receptor homolog, M-T7, inhibits interferon-γ in a species-specific manner Journal of Biological Chemistry. 270: 3031-3038. PMID 7852384 DOI: 10.1074/Jbc.270.7.3031  0.392
1995 Mossman K, Ostergaard H, Upton C, McFadden G. Myxoma virus and shope fibroma virus encode dual-specificity tyrosine/serine phosphatases which are essential for virus viability Virology. 206: 572-582. PMID 7831813 DOI: 10.1016/S0042-6822(95)80074-3  0.469
1995 McFadden G, Graham K, Ellison K, Barry M, Macen J, Schreiber M, Mossman K, Nash P, Lalani A, Everett H. Interruption of cytokine networks by poxviruses: Lessons from myxoma virus Journal of Leukocyte Biology. 57: 731-738. PMID 7759953 DOI: 10.1002/Jlb.57.5.731  0.745
1995 Mossman K, Upton C, Buller RM, McFadden G. Species specificity of ectromelia virus and vaccinia virus interferon-gamma binding proteins. Virology. 208: 762-9. PMID 7747448 DOI: 10.1006/Viro.1995.1208  0.481
1995 Barry M, Lee SF, Boshkov L, Mcfadden G. Myxoma virus induces extensive CD4 downregulation and dissociation of p56lck in infected rabbit CD4+ T lymphocytes. Journal of Virology. 69: 5243-5251. PMID 7636966 DOI: 10.1128/Jvi.69.9.5243-5251.1995  0.366
1995 McFadden G. Getting to know you: Viruses meet CD40 ligand Nature Medicine. 1: 408-409. PMID 7585082 DOI: 10.1038/Nm0595-408  0.323
1994 McFadden G, Kane K. How DNA viruses perturb functional MHC expression to alter immune recognition Advances in Cancer Research. 63: 117-209. PMID 8036987 DOI: 10.1016/S0065-230X(08)60400-5  0.418
1994 Schreiber M, McFadden G. The myxoma virus TNF-receptor homologue (T2) inhibits tumor necrosis factor-α in a species-specific fashion Virology. 204: 692-705. PMID 7941338 DOI: 10.1006/Viro.1994.1585  0.432
1994 Upton C, Schiff L, Rice SA, Dowdeswell T, Yang X, McFadden G. A poxvirus protein with a RING finger motif binds zinc and localizes in virus factories. Journal of Virology. 68: 4186-4195. DOI: 10.1128/Jvi.68.7.4186-4195.1994  0.469
1994 McFadden G, Graham K. Modulation of cytokine networks by poxvirus: The myxoma virus model Seminars in Virology. 5: 421-429. DOI: 10.1006/Smvy.1994.1048  0.498
1993 Stuart DT, Upton C, Higman MA, Niles EG, Mcfadden G. A poxvirus-encoded uracil DNA glycosylase is essential for virus viability Journal of Virology. 67: 2503-2512. PMID 8474156 DOI: 10.1128/Jvi.67.5.2503-2512.1993  0.425
1993 Upton C, Stuart DT, Mcfadden G. Identification of a poxvirus gene encoding a uracil DNA glycosylase Proceedings of the National Academy of Sciences of the United States of America. 90: 4518-4522. PMID 8389453 DOI: 10.1073/Pnas.90.10.4518  0.359
1993 Opgenorth A, Nation N, Graham K, McFadden G. Transforming Growth Factor Alpha, Shope Fibroma Growth Factor, and Vaccinia Growth Factor Can Replace Myxoma Growth Factor in the Induction of Myxomatosis in Rabbits Virology. 192: 701-709. PMID 8380671 DOI: 10.1006/Viro.1993.1092  0.38
1993 Macen JL, Upton C, Nation N, McFadden G. SERP1, a serine proteinase inhibitor encoded by myxoma virus, is a secreted glycoprotein that interferes with inflammation. Virology. 195: 348-63. PMID 8337817 DOI: 10.1006/Viro.1993.1385  0.499
1992 Stuart D, Ellison K, Graham K, McFadden G. In vitro resolution of poxvirus replicative intermediates into linear minichromosomes with hairpin termini by a virally induced Holliday junction endonuclease. Journal of Virology. 66: 1551-63. PMID 1738203 DOI: 10.1128/Jvi.66.3.1551-1563.1992  0.46
1992 Opgenorth A, Graham K, Nation N, Strayer D, McFadden G. Deletion analysis of two tandemly arranged virulence genes in myxoma virus, M11L and myxoma growth factor. Journal of Virology. 66: 4720-4731. PMID 1629952 DOI: 10.1128/Jvi.66.8.4720-4731.1992  0.436
1992 Upton C, Mossman K, McFadden G. Encoding of a homolog of the IFN-γ receptor by myxoma virus Science. 258: 1369-1372. PMID 1455233 DOI: 10.1126/Science.1455233  0.473
1992 Graham KA, Opgenorth A, Upton C, McFadden G. Myxoma virus M11L ORF encodes a protein for which cell surface localization is critical in manifestation of viral virulence Virology. 191: 112-124. PMID 1413498 DOI: 10.1016/0042-6822(92)90172-L  0.466
1992 Massung RF, McFadden G, Moyer RW. Nucleotide sequence analysis of a unique near-terminal region of the tumorigenic poxvirus, Shope fibroma virus Journal of General Virology. 73: 2903-2911. PMID 1331293 DOI: 10.1099/0022-1317-73-11-2903  0.375
1992 Boshkov LK, Macen JL, Mcfadden G. Virus-induced loss of class I MHC antigens from the surface of cells infected with myxoma virus and malignant rabbit fibroma virus Journal of Immunology. 148: 881-887. PMID 1309843  0.33
1992 Opgenorth A, Strayer D, Upton C, McFadden G. Deletion of the growth factor gene related to EGF and TGFα reduces virulence of malignant rabbit fibroma virus Virology. 186: 175-191. PMID 1309274 DOI: 10.1016/0042-6822(92)90072-W  0.432
1991 Smith CA, Davis T, Wignall JM, Din WS, Farrah T, Upton C, McFadden G, Goodwin RG. T2 open reading frame from the Shope fibroma virus encodes a soluble form of the TNF receptor. Biochemical and Biophysical Research Communications. 176: 335-42. PMID 1850261 DOI: 10.1016/0006-291X(91)90929-2  0.416
1991 Stuart D, Graham K, Schreiber M, Macaulay C, McFadden G. The target DNA sequence for resolution of poxvirus replicative intermediates is an active late promoter. Journal of Virology. 65: 61-70. PMID 1845909 DOI: 10.1128/Jvi.65.1.61-70.1991  0.404
1991 Upton C, Stuart D, McFadden G. Identification and DNA sequence of the large subunit of the capping enzyme from Shope fibroma virus Virology. 183: 773-777. PMID 1649507 DOI: 10.1016/0042-6822(91)91009-6  0.383
1990 Chang W, Macaulay C, Hu S, Tam JP, McFadden G. Tumorigenic poxviruses: Characterization of the expression of an epidermal growth factor related gene in shope fibroma virus Virology. 179: 926-930. PMID 2173269 DOI: 10.1016/0042-6822(90)90170-V  0.357
1990 Upton C, Macen JL, Wishart DS, McFadden G. Myxoma virus and malignant rabbit fibroma virus encode a serpin-like protein important for virus virulence. Virology. 179: 618-31. PMID 2173255 DOI: 10.1016/0042-6822(90)90129-F  0.499
1990 Upton C, Opgenorth A, Traktman P, McFadden G. Identification and DNA sequence of the Shope fibroma virus DNA topoisomerase gene. Virology. 176: 439-47. PMID 2161144 DOI: 10.1016/0042-6822(90)90013-H  0.343
1989 Macaulay C, McFadden G. Tumorigenic poxviruses: Characterization of an early promoter from shope fibroma virus Virology. 172: 237-246. PMID 2549712 DOI: 10.1016/0042-6822(89)90125-6  0.364
1988 Upton C, Macen JL, Maranchuk RA, DeLange AM, McFadden G. Tumorigenic poxviruses: fine analysis of the recombination junctions in malignant rabbit fibroma virus, a recombinant between Shope fibroma virus and myxoma virus. Virology. 166: 229-39. PMID 2842947 DOI: 10.1016/0042-6822(88)90164-X  0.367
1988 Evans DH, Stuart D, McFadden G. High levels of genetic recombination among cotransfected plasmid DNAs in poxvirus-infected mammalian cells Journal of Virology. 62: 367-375. PMID 2826801 DOI: 10.1128/Jvi.62.2.367-375.1988  0.441
1987 DeLange AM, McFadden G. Efficient resolution of replicated poxvirus telomeres to native hairpin structures requires two inverted symmetrical copies of a core target DNA sequence Journal of Virology. 61: 1957-1963. PMID 3033323 DOI: 10.1128/Jvi.61.6.1957-1963.1987  0.339
1987 Upton C, Macen JL, McFadden G. Mapping and sequencing of a gene from myxoma virus that is related to those encoding epidermal growth factor and transforming growth factor alpha Journal of Virology. 61: 1271-1275. PMID 3029424 DOI: 10.1128/Jvi.61.4.1271-1275.1987  0.406
1987 Macaulay C, Upton C, McFadden G. Tumorigenic poxviruses: Transcriptional mapping of the terminal inverted repeats of shope fibroma virus Virology. 158: 381-393. PMID 2884778 DOI: 10.1016/0042-6822(87)90210-8  0.34
1987 Dickie P, Morgan AR, McFadden G. Cruciform extrusion in plasmids bearing the replicative intermediate configuration of a poxvirus telomere Journal of Molecular Biology. 196: 541-558. PMID 2824785 DOI: 10.1016/0022-2836(87)90031-3  0.336
1987 Upton C, DeLange AM, McFadden G. Tumorigenic poxviruses: Genomic organization and dna sequence of the telomeric region of the shope fibroma virus genome Virology. 160: 20-30. PMID 2820128 DOI: 10.1016/0042-6822(87)90039-0  0.345
1986 Upton C, McFadden G. DNA sequence homology between the terminal inverted repeats of Shope fibroma virus and an endogenous cellular plasmid species Molecular and Cellular Biology. 6: 265-276. PMID 3023828 DOI: 10.1128/Mcb.6.1.265  0.334
1986 Upton C, McFadden G. Identification and nucleotide sequence of the thymidine kinase gene of Shope fibroma virus Journal of Virology. 60: 920-927. PMID 3023681 DOI: 10.1128/Jvi.60.3.920-927.1986  0.357
1986 Upton C, Carrell RW, McFadden G. A novel member of the serpin superfamily is encoded on a circular plasmid-like DNA species isolated from rabbit cells Febs Letters. 207: 115-120. PMID 3021526 DOI: 10.1016/0014-5793(86)80023-0  0.361
1986 Upton C, McFadden G. Tumorigenic poxviruses: Analysis of viral DNA sequences implicated in the tumorigenicity of shope fibroma virus and malignant rabbit virus Virology. 152: 308-321. PMID 3014722 DOI: 10.1016/0042-6822(86)90134-0  0.417
1986 DeLange AM, McFadden G. Sequence-nonspecific replication of transfected plasmid DNA in poxvirus-infected cells Proceedings of the National Academy of Sciences of the United States of America. 83: 614-618. PMID 3003742 DOI: 10.1073/Pnas.83.3.614  0.371
1986 DeLange AM, Reddy M, Scraba D, Upton C, McFadden G. Replication and resolution of cloned poxvirus telomeres in vivo generates linear minichromosomes with intact viral hairpin termini. Journal of Virology. 59: 249-259. DOI: 10.1128/Jvi.59.2.249-259.1986  0.382
1985 Block W, Upton C, McFadden G. Tumorigenic poxviruses: genomic organization of malignant rabbit virus, a recombinant between shope fibroma virus and myxoma virus Virology. 140: 113-124. PMID 2981446 DOI: 10.1016/0042-6822(85)90450-7  0.369
1984 DeLange AM, Futcher B, Morgan R, McFadden G. Cloning of the vaccinia virus telomere in a yeast plasmid vector. Gene. 27: 13-21. PMID 6325299 DOI: 10.1016/0378-1119(84)90234-8  0.385
1984 Delange AM, Macaulay C, Block W, Mueller T, McFadden G. Tumorigenic poxviruses: construction of the composite physical map of the Shope fibroma virus genome. Journal of Virology. 50: 408-416. PMID 6323741 DOI: 10.1128/Jvi.50.2.408-416.1984  0.354
1983 Wills A, Delange AM, Gregson C, Macaulay C, Mcfadden G. Physical characterization and molecular cloning of the Shope fibroma virus DNA genome. Virology. 130: 403-414. PMID 6316637 DOI: 10.1016/0042-6822(83)90095-8  0.334
1980 McFadden G, Dales S. Biogenesis of poxviruses: Preliminary characterization of conditional lethal mutants of vaccinia virus defective in DNA synthesis Virology. 103: 68-79. PMID 6245533 DOI: 10.1016/0042-6822(80)90126-9  0.332
1980 McFadden G, Essani K, Dales S. A new endonuclease restriction site which is at the locus of a temperature-sensitive mutation in vaccinia virus is associated with true and pseudoreversion Virology. 101: 277-280. PMID 6243824 DOI: 10.1016/0042-6822(80)90503-6  0.362
1979 McFadden G, Dales S. Biogenesis of poxviruses: Mirror-image deletions in vaccinia virus DNA Cell. 18: 101-108. PMID 509515 DOI: 10.1016/0092-8674(79)90358-1  0.373
1979 McFadden G, Pace WE, Purres J, Dales S. Biogenesis of poxviruses: Transitory expression of Molluscum contagiosum early functions Virology. 94: 297-313. PMID 452419 DOI: 10.1016/0042-6822(79)90463-X  0.432
1979 Silver M, McFadden G, Wilton S, Dales S. Biogenesis of poxviruses: role for the DNA-dependent RNA polymerase II of the host during expression of late functions Proceedings of the National Academy of Sciences of the United States of America. 76: 4122-4125. PMID 226996 DOI: 10.1073/Pnas.76.8.4122  0.359
1974 McFadden G, Denhardt DT. Mechanism of replication of phiX174 single stranded DNA. IX. Requirement for the Escherichia coli dnaG protein Journal of Virology. 14: 1070-1075. PMID 4610175 DOI: 10.1128/Jvi.14.5.1070-1075.1974  0.307
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