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Lena Serghides, Ph.D. - Publications

Affiliations: 
2002 University of Toronto, Toronto, ON, Canada 
Area:
Cell Biology, Public Health
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49 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2020 Yampolsky M, Shlakhter O, Deng D, Kala S, Walmsley SL, Murphy KE, Yudin MH, MacGillivray J, Loutfy M, Dunk C, Serghides L. Exploring the impact of HIV infection and antiretroviral therapy on placenta morphology. Placenta. 104: 102-109. PMID 33310298 DOI: 10.1016/j.placenta.2020.12.004  0.6
2018 Varo R, Crowley VM, Sitoe A, Madrid L, Serghides L, Kain KC, Bassat Q. Adjunctive therapy for severe malaria: a review and critical appraisal. Malaria Journal. 17: 47. PMID 29361945 DOI: 10.1186/s12936-018-2195-7  0.96
2017 McDonald CR, Conroy AL, Gamble JL, Papp E, Hawkes M, Olwoch P, Natureeba P, Kamya M, Silverman M, Cohan D, Koss CA, Dorsey G, Kain KC, Serghides L. Estradiol Levels Are Altered in Human Immunodeficiency Virus-Infected Pregnant Women Randomized to Efavirenz-Versus Lopinavir/Ritonavir-Based Antiretroviral Therapy. Clinical Infectious Diseases : An Official Publication of the Infectious Diseases Society of America. PMID 29136115 DOI: 10.1093/cid/cix772  0.96
2017 Balogun KA, Lenis MG, Papp E, Loutfy M, Yudin MH, MacGillivray J, Walmsley SL, Silverman M, Serghides L. Elevated levels of estradiol in HIV-positive pregnant women on protease inhibitor-based regimens. Clinical Infectious Diseases : An Official Publication of the Infectious Diseases Society of America. PMID 29020282 DOI: 10.1093/cid/cix761  0.6
2017 Varo R, Crowley VM, Sitoe A, Madrid L, Serghides L, Bila R, Mucavele H, Mayor A, Bassat Q, Kain KC. Safety and tolerability of adjunctive rosiglitazone treatment for children with uncomplicated malaria. Malaria Journal. 16: 215. PMID 28535809 DOI: 10.1186/s12936-017-1858-0  0.96
2017 Kennedy VL, Collins M, Yudin MH, Serghides L, Walmsley S, Angel JB, Ongoiba F, Powis J, Smaill F, Tharao W, Rachlis A, Silverman M, Sandre R, Regier DA, Loutfy M. Exploring the Factors Considered by People Living with HIV and Their Partners during Preconception. Journal of the International Association of Providers of Aids Care. 16: 239-246. PMID 28485707 DOI: 10.1177/2325957416682089  0.6
2017 Siou K, Walmsley SL, Murphy KE, Raboud J, Loutfy M, Yudin MH, Silverman M, Ladhani NN, Papp E, Serghides L. Erratum to: Progesterone supplementation for HIV-positive pregnant women on protease inhibitor-based antiretroviral regimens (the ProSPAR study): a study protocol for a pilot randomized controlled trial. Pilot and Feasibility Studies. 3: 21. PMID 28461906 DOI: 10.1186/s40814-017-0135-x  0.6
2016 Siou K, Walmsley SL, Murphy KE, Raboud J, Loutfy M, Yudin MH, Silverman M, Ladhani NN, Serghides L. Progesterone supplementation for HIV-positive pregnant women on protease inhibitor-based antiretroviral regimens (the ProSPAR study): a study protocol for a pilot randomized controlled trial. Pilot and Feasibility Studies. 2: 49. PMID 27965866 DOI: 10.1186/s40814-016-0087-6  0.6
2016 Ayi K, Lu Z, Serghides L, Ho JM, Wang JC, Liles WC, Kain KC. CD47-SIRPα Interactions Regulate Macrophage Uptake of Plasmodium falciparum-infected Erythrocytes and Clearance of Malaria in vivo. Infection and Immunity. PMID 27091932 DOI: 10.1128/IAI.01426-15  0.96
2016 Papp E, Balogun K, Banko N, Mohammadi H, Loutfy M, Yudin MH, Shah R, MacGillivray J, Murphy KE, Walmsley SL, Silverman M, Serghides L. Low prolactin and high 20alpha-hydroxysteroid dehydrogenase contribute to lower progesterone in HIV-infected protease inhibitor-cART exposed pregnant women. The Journal of Infectious Diseases. PMID 26740274 DOI: 10.1093/infdis/jiw004  0.96
2015 Finney C, Serghides L. An In Vitro Model for Measuring Immune Responses to Malaria in the Context of HIV Co-infection. Journal of Visualized Experiments : Jove. PMID 26485041 DOI: 10.3791/52969  0.96
2015 Serghides L, Finney CA, Ayi K, Loutfy M, Kain KC. Chronic HIV infection impairs nonopsonic phagocytosis of malaria parasites. Journal of Acquired Immune Deficiency Syndromes (1999). 68: 128-32. PMID 25415293 DOI: 10.1097/QAI.0000000000000427  0.96
2015 Papp E, Mohammadi H, Loutfy MR, Yudin MH, Murphy KE, Walmsley SL, Shah R, MacGillivray J, Silverman M, Serghides L. HIV protease inhibitor use during pregnancy is associated with decreased progesterone levels, suggesting a potential mechanism contributing to fetal growth restriction. The Journal of Infectious Diseases. 211: 10-8. PMID 25030058 DOI: 10.1093/infdis/jiu393  0.96
2015 Hawkes M, Serghides L. Optimizing malaria treatment in the community Optimizing Treatment For Children in the Developing World. 251-264. DOI: 10.1007/978-3-319-15750-4_22  0.96
2014 Serghides L, McDonald CR, Lu Z, Friedel M, Cui C, Ho KT, Mount HT, Sled JG, Kain KC. PPARγ agonists improve survival and neurocognitive outcomes in experimental cerebral malaria and induce neuroprotective pathways in human malaria. Plos Pathogens. 10: e1003980. PMID 24603727 DOI: 10.1371/journal.ppat.1003980  0.96
2014 Chege D, Higgins SJ, McDonald CR, Shahabi K, Huibner S, Kain T, Kain D, Kim CJ, Leung N, Amin M, Geddes K, Serghides L, Philpott DJ, Kimani J, Gray-Owen S, et al. Murine Plasmodium chabaudi malaria increases mucosal immune activation and the expression of putative HIV susceptibility markers in the gut and genital mucosae. Journal of Acquired Immune Deficiency Syndromes (1999). 65: 517-25. PMID 24256632 DOI: 10.1097/QAI.0000000000000056  0.96
2014 Kennedy VL, Serghides L, Raboud JM, Su D, Blitz S, Hart TA, Walmsley SL, Angel JB, Smaill FM, Ralph ED, Tharao WE, Loutfy MR. The importance of motherhood in HIV-positive women of reproductive age in Ontario, Canada. Aids Care. 26: 777-84. PMID 24206065 DOI: 10.1080/09540121.2013.855295  0.96
2014 Kim H, Erdman LK, Lu Z, Serghides L, Zhong K, Dhabangi A, Musoke C, Gerard C, Cserti-Gazdewich C, Liles WC, Kain KC. Functional roles for C5a and C5aR but not C5L2 in the pathogenesis of human and experimental cerebral malaria. Infection and Immunity. 82: 371-9. PMID 24191300 DOI: 10.1128/IAI.01246-13  0.96
2013 Finney CA, Ayi K, Wasmuth JD, Sheth PM, Kaul R, Loutfy M, Kain KC, Serghides L. HIV infection deregulates Tim-3 expression on innate cells: combination antiretroviral therapy results in partial restoration. Journal of Acquired Immune Deficiency Syndromes (1999). 63: 161-7. PMID 23314411 DOI: 10.1097/QAI.0b013e318285cf13  0.96
2013 Finney CA, Ayi K, Wasmuth JD, Sheth PM, Kaul R, Loutfy MR, Kain KC, Serghides L. HIV infection deregulates innate immunity to malaria despite combination antiretroviral therapy. Aids (London, England). 27: 325-35. PMID 23291537 DOI: 10.1097/QAD.0b013e32835b3dfa  0.96
2012 Miller C, Miller M, McMullin B, Regev G, Serghides L, Kain K, Road J, Av-Gay Y. A phase I clinical study of inhaled nitric oxide in healthy adults. Journal of Cystic Fibrosis : Official Journal of the European Cystic Fibrosis Society. 11: 324-31. PMID 22520076 DOI: 10.1016/j.jcf.2012.01.003  0.96
2012 Serghides L. The Case for the Use of PPARγ Agonists as an Adjunctive Therapy for Cerebral Malaria. Ppar Research. 2012: 513865. PMID 21772838 DOI: 10.1155/2012/513865  0.96
2011 Serghides L, Kim H, Lu Z, Kain DC, Miller C, Francis RC, Liles WC, Zapol WM, Kain KC. Inhaled nitric oxide reduces endothelial activation and parasite accumulation in the brain, and enhances survival in experimental cerebral malaria. Plos One. 6: e27714. PMID 22110737 DOI: 10.1371/journal.pone.0027714  0.96
2011 Hawkes M, Opoka RO, Namasopo S, Miller C, Conroy AL, Serghides L, Kim H, Thampi N, Liles WC, John CC, Kain KC. Nitric oxide for the adjunctive treatment of severe malaria: hypothesis and rationale. Medical Hypotheses. 77: 437-44. PMID 21745716 DOI: 10.1016/j.mehy.2011.06.003  0.96
2010 Labbé K, Miu J, Yeretssian G, Serghides L, Tam M, Finney CA, Erdman LK, Goulet ML, Kain KC, Stevenson MM, Saleh M. Caspase-12 dampens the immune response to malaria independently of the inflammasome by targeting NF-kappaB signaling. Journal of Immunology (Baltimore, Md. : 1950). 185: 5495-502. PMID 20876354 DOI: 10.4049/jimmunol.1002517  0.96
2010 Stevenson MM, Gros P, Olivier M, Fortin A, Serghides L. Cerebral malaria: human versus mouse studies. Trends in Parasitology. 26: 274-5. PMID 20382077 DOI: 10.1016/j.pt.2010.03.008  0.96
2009 Boggild AK, Krudsood S, Patel SN, Serghides L, Tangpukdee N, Katz K, Wilairatana P, Liles WC, Looareesuwan S, Kain KC. Use of peroxisome proliferator-activated receptor gamma agonists as adjunctive treatment for Plasmodium falciparum malaria: a randomized, double-blind, placebo-controlled trial. Clinical Infectious Diseases : An Official Publication of the Infectious Diseases Society of America. 49: 841-9. PMID 19673614 DOI: 10.1086/605431  0.96
2009 Serghides L, Patel SN, Ayi K, Lu Z, Gowda DC, Liles WC, Kain KC. Rosiglitazone modulates the innate immune response to Plasmodium falciparum infection and improves outcome in experimental cerebral malaria. The Journal of Infectious Diseases. 199: 1536-45. PMID 19392627 DOI: 10.1086/598222  0.96
2009 Conroy A, Serghides L, Finney C, Owino SO, Kumar S, Gowda DC, Liles WC, Moore JM, Kain KC. C5a enhances dysregulated inflammatory and angiogenic responses to malaria in vitro: potential implications for placental malaria. Plos One. 4: e4953. PMID 19308263 DOI: 10.1371/journal.pone.0004953  0.96
2008 Patel SN, Berghout J, Lovegrove FE, Ayi K, Conroy A, Serghides L, Min-oo G, Gowda DC, Sarma JV, Rittirsch D, Ward PA, Liles WC, Gros P, Kain KC. C5 deficiency and C5a or C5aR blockade protects against cerebral malaria. The Journal of Experimental Medicine. 205: 1133-43. PMID 18426986 DOI: 10.1084/jem.20072248  0.96
2008 Ayi K, Min-Oo G, Serghides L, Crockett M, Kirby-Allen M, Quirt I, Gros P, Kain KC. Pyruvate kinase deficiency and malaria. The New England Journal of Medicine. 358: 1805-10. PMID 18420493 DOI: 10.1056/NEJMoa072464  0.96
2007 Keen J, Serghides L, Ayi K, Patel SN, Ayisi J, van Eijk A, Steketee R, Udhayakumar V, Kain KC. HIV impairs opsonic phagocytic clearance of pregnancy-associated malaria parasites. Plos Medicine. 4: e181. PMID 17535103 DOI: 10.1371/journal.pmed.0040181  0.96
2007 Patel SN, Lu Z, Ayi K, Serghides L, Gowda DC, Kain KC. Disruption of CD36 impairs cytokine response to Plasmodium falciparum glycosylphosphatidylinositol and confers susceptibility to severe and fatal malaria in vivo. Journal of Immunology (Baltimore, Md. : 1950). 178: 3954-61. PMID 17339496  0.96
2006 Lu Z, Serghides L, Patel SN, Degousee N, Rubin BB, Krishnegowda G, Gowda DC, Karin M, Kain KC. Disruption of JNK2 decreases the cytokine response to Plasmodium falciparum glycosylphosphatidylinositol in vitro and confers protection in a cerebral malaria model. Journal of Immunology (Baltimore, Md. : 1950). 177: 6344-52. PMID 17056565  0.96
2006 Serghides L, Vidric M, Watts TH. Approaches to studying costimulation of human antiviral T cell responses: prospects for immunotherapeutic vaccines. Immunologic Research. 35: 137-50. PMID 17003516 DOI: 10.1385/IR:35:1:137  0.96
2006 Serghides L, Patel SN, Ayi K, Kain KC. Placental chondroitin sulfate A-binding malarial isolates evade innate phagocytic clearance. The Journal of Infectious Diseases. 194: 133-9. PMID 16741892 DOI: 10.1086/504721  0.96
2005 Serghides L, Bukczynski J, Wen T, Wang C, Routy JP, Boulassel MR, Sekaly RP, Ostrowski M, Bernard NF, Watts TH. Evaluation of OX40 ligand as a costimulator of human antiviral memory CD8 T cell responses: comparison with B7.1 and 4-1BBL. Journal of Immunology (Baltimore, Md. : 1950). 175: 6368-77. PMID 16272289  0.96
2005 Ayi K, Patel SN, Serghides L, Smith TG, Kain KC. Nonopsonic phagocytosis of erythrocytes infected with ring-stage Plasmodium falciparum. Infection and Immunity. 73: 2559-63. PMID 15784606 DOI: 10.1128/IAI.73.4.2559-2563.2005  0.96
2005 Serghides L, Kain KC. Peroxisome proliferator-activated receptor gamma and retinoid X receptor agonists have minimal effects on the interaction of endothelial cells with Plasmodium falciparum-infected erythrocytes. Infection and Immunity. 73: 1209-13. PMID 15664966 DOI: 10.1128/IAI.73.2.1209-1213.2005  0.96
2004 Patel SN, Serghides L, Smith TG, Febbraio M, Silverstein RL, Kurtz TW, Pravenec M, Kain KC. CD36 mediates the phagocytosis of Plasmodium falciparum-infected erythrocytes by rodent macrophages. The Journal of Infectious Diseases. 189: 204-13. PMID 14722884 DOI: 10.1086/380764  0.96
2003 Nathoo S, Serghides L, Kain KC. Effect of HIV-1 antiretroviral drugs on cytoadherence and phagocytic clearance of Plasmodium falciparum-parasitised erythrocytes. Lancet (London, England). 362: 1039-41. PMID 14522535 DOI: 10.1016/S0140-6736(03)14414-5  0.96
2003 Serghides L, Smith TG, Patel SN, Kain KC. CD36 and malaria: friends or foes? Trends in Parasitology. 19: 461-9. PMID 14519584 DOI: 10.1016/j.pt.2003.08.006  0.96
2003 Smith TG, Serghides L, Patel SN, Febbraio M, Silverstein RL, Kain KC. CD36-mediated nonopsonic phagocytosis of erythrocytes infected with stage I and IIA gametocytes of Plasmodium falciparum. Infection and Immunity. 71: 393-400. PMID 12496189 DOI: 10.1128/IAI.71.1.393-400.2003  0.96
2002 Smith TG, Ayi K, Serghides L, Mcallister CD, Kain KC. Innate immunity to malaria caused by Plasmodium falciparum. Clinical and Investigative Medicine. MéDecine Clinique Et Experimentale. 25: 262-72. PMID 12516999  0.96
2002 Serghides L, Kain KC. Mechanism of protection induced by vitamin A in falciparum malaria. Lancet (London, England). 359: 1404-6. PMID 11978340 DOI: 10.1016/S0140-6736(02)08360-5  0.96
2002 Serghides L, Nathoo S, Walmsley S, Kain KC. CD36 deficiency induced by antiretroviral therapy. Aids (London, England). 16: 353-8. PMID 11834946 DOI: 10.1097/00002030-200202150-00006  0.96
2001 Serghides L, Kain KC. Peroxisome proliferator-activated receptor gamma-retinoid X receptor agonists increase CD36-dependent phagocytosis of Plasmodium falciparum-parasitized erythrocytes and decrease malaria-induced TNF-alpha secretion by monocytes/macrophages. Journal of Immunology (Baltimore, Md. : 1950). 166: 6742-8. PMID 11359831  0.96
2000 McGilvray ID, Serghides L, Kapus A, Rotstein OD, Kain KC. Nonopsonic monocyte/macrophage phagocytosis of Plasmodium falciparum-parasitized erythrocytes: a role for CD36 in malarial clearance. Blood. 96: 3231-40. PMID 11050008  0.96
1998 Serghides L, Crandall I, Hull E, Kain KC. The Plasmodium falciparum-CD36 interaction is modified by a single amino acid substitution in CD36. Blood. 92: 1814-9. PMID 9716613  0.96
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