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Ryan M. O'Connell, Ph.D. - Publications

Affiliations: 
2005 University of California, Los Angeles, Los Angeles, CA 
Area:
Molecular Biology, Immunology, Cell Biology, Pathology, Microbiology Biology
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59 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2020 Syage AR, Ekiz HA, Skinner DD, Stone C, O'Connell RM, Lane TE. Single-cell RNA sequencing reveals the diversity of the immunological landscape following CNS infection by a murine coronavirus. Journal of Virology. PMID 32999036 DOI: 10.1128/JVI.01295-20  0.329
2020 Nelson MC, O'Connell RM. MicroRNAs: At the Interface of Metabolic Pathways and Inflammatory Responses by Macrophages. Frontiers in Immunology. 11: 1797. PMID 32922393 DOI: 10.3389/Fimmu.2020.01797  0.364
2020 Bhatlekar S, Manne BK, Basak I, Edelstein LC, Tugolukova E, Stoller ML, Cody MJ, Morley SC, Nagalla S, Weyrich AS, Rowley JW, O'Connell RM, Rondina MT, Campbell RA, Bray PF. miR-125a-5p Regulates Megakaryocyte Proplatelet Formation Via the Actin Bundling Protein L-Plastin. Blood. PMID 32844999 DOI: 10.1182/Blood.2020005230  0.304
2020 Niu F, Kazimierska M, Nolte IM, Terpstra MM, de Jong D, Koerts J, van der Sluis T, Rutgers B, O'Connell RM, Kok K, van den Berg A, Dzikiewicz-Krawczyk A, Kluiver J. The miR-26b-5p/KPNA2 Axis Is an Important Regulator of Burkitt Lymphoma Cell Growth. Cancers. 12. PMID 32512858 DOI: 10.3390/Cancers12061464  0.335
2020 Mangale V, Syage AR, Ekiz HA, Skinner DD, Cheng Y, Stone CL, Brown RM, O'Connell RM, Green KN, Lane TE. Microglia influence host defense, disease, and repair following murine coronavirus infection of the central nervous system. Glia. PMID 32449994 DOI: 10.1002/Glia.23844  0.394
2019 Brown DG, Soto R, Yandamuri S, Stone C, Dickey L, Gomes-Neto JC, Pastuzyn ED, Bell R, Petersen C, Buhrke K, Fujinami RS, O'Connell RM, Stephens WZ, Shepherd JD, Lane TE, et al. The microbiota protects from viral-induced neurologic damage through microglia-intrinsic TLR signaling. Elife. 8. PMID 31309928 DOI: 10.7554/Elife.47117  0.465
2019 Gogokhia L, Buhrke K, Bell R, Hoffman B, Brown DG, Hanke-Gogokhia C, Ajami NJ, Wong MC, Ghazaryan A, Valentine JF, Porter N, Martens E, O'Connell R, Jacob V, Scherl E, et al. Expansion of Bacteriophages Is Linked to Aggravated Intestinal Inflammation and Colitis. Cell Host & Microbe. 25: 285-299.e8. PMID 30763538 DOI: 10.1016/j.chom.2019.01.008  0.325
2019 Brown DG, Soto R, Yandamuri S, Stone C, Dickey L, Gomes-Neto JC, Pastuzyn ED, Bell R, Petersen C, Buhrke K, Fujinami RS, O'Connell RM, Stephens WZ, Shepherd JD, Lane TE, et al. Author response: The microbiota protects from viral-induced neurologic damage through microglia-intrinsic TLR signaling Elife. DOI: 10.7554/Elife.47117.022  0.405
2018 Huffaker T, O'Connell R. 004 T cell specific microRNA-155 regulates the immune landscape of B16f10 melanoma Journal of Investigative Dermatology. 138: S1. DOI: 10.1016/J.Jid.2018.03.008  0.35
2017 Alexander M, Ramstead AG, Bauer KM, Lee SH, Runtsch MC, Wallace J, Huffaker TB, Larsen DK, Tolmachova T, Seabra MC, Round JL, Ward DM, O'Connell RM. Rab27-Dependent Exosome Production Inhibits Chronic Inflammation and Enables Acute Responses to Inflammatory Stimuli. Journal of Immunology (Baltimore, Md. : 1950). PMID 28978688 DOI: 10.4049/Jimmunol.1700904  0.446
2017 Wallace JA, Kagele DA, Eiring AM, Kim CN, Hu R, Runtsch MC, Alexander M, Huffaker TB, Lee SH, Patel AB, Mosbruger TL, Voth W, Rao DS, Miles RR, Round JL, et al. miR-155 promotes FLT3-ITD-induced myeloproliferative disease through inhibition of the interferon response. Blood. PMID 28432220 DOI: 10.1182/Blood-2016-09-740209  0.343
2017 Dickey LL, Hanley TM, Huffaker TB, Ramstead AG, O'Connell RM, Lane TE. MicroRNA 155 and viral-induced neuroinflammation. Journal of Neuroimmunology. PMID 28139244 DOI: 10.1016/J.Jneuroim.2017.01.016  0.459
2016 Hawkes JE, Nguyen GH, Fujita M, Florell SR, Callis Duffin K, Krueger GG, O'Connell RM. microRNAs in Psoriasis. The Journal of Investigative Dermatology. 136: 365-71. PMID 26802234 DOI: 10.1038/Jid.2015.409  0.341
2016 Wallace J, Kagele D, Hu R, Runtsch M, Alexander M, Huffaker T, Mosbruger T, Rao DS, Miles RR, Round J, O'Connell RM. MiR-155 Promotes FLT3-ITD-Induced Myeloproliferative Disease through Inhibition of Interferon Signaling Blood. 128: 2853-2853. DOI: 10.1182/Blood.V128.22.2853.2853  0.349
2015 Kubinak JL, Stephens WZ, Soto R, Petersen C, Chiaro T, Gogokhia L, Bell R, Ajami NJ, Petrosino JF, Morrison L, Potts WK, Jensen PE, O'Connell RM, Round JL. MHC variation sculpts individualized microbial communities that control susceptibility to enteric infection. Nature Communications. 6: 8642. PMID 26494419 DOI: 10.1038/Ncomms9642  0.359
2015 Alexander M, Hu R, Runtsch MC, Kagele DA, Mosbruger TL, Tolmachova T, Seabra MC, Round JL, Ward DM, O'Connell RM. Exosome-delivered microRNAs modulate the inflammatory response to endotoxin. Nature Communications. 6: 7321. PMID 26084661 DOI: 10.1038/Ncomms8321  0.378
2015 Kwon OS, Tanner RE, Barrows KM, Runtsch M, Symons JD, Jalili T, Bikman BT, McClain DA, O'Connell RM, Drummond MJ. MyD88 regulates physical inactivity-induced skeletal muscle inflammation, ceramide biosynthesis signaling, and glucose intolerance. American Journal of Physiology. Endocrinology and Metabolism. 309: E11-21. PMID 25968578 DOI: 10.1152/Ajpendo.00124.2015  0.332
2015 Wallace J, Kagele D, Hu R, Runtsch M, Alexander M, Huffaker T, Mosbruger T, Dahlem T, Stephens WZ, Rao DS, Miles RR, Round J, O'Connell RM. Genome-Wide Crispr-Cas9 Screen Identifies Functionally Relevant Micro-RNAs in FLT3-ITD+ AML Blood. 126: 3823-3823. DOI: 10.1182/Blood.V126.23.3823.3823  0.357
2014 Lochhead RB, Ma Y, Zachary JF, Baltimore D, Zhao JL, Weis JH, O'Connell RM, Weis JJ. MicroRNA-146a provides feedback regulation of lyme arthritis but not carditis during infection with Borrelia burgdorferi. Plos Pathogens. 10: e1004212. PMID 24967703 DOI: 10.1371/Journal.Ppat.1004212  0.564
2014 Zhao JL, Ma C, O'Connell RM, Mehta A, DiLoreto R, Heath JR, Baltimore D. Conversion of danger signals into cytokine signals by hematopoietic stem and progenitor cells for regulation of stress-induced hematopoiesis. Cell Stem Cell. 14: 445-59. PMID 24561084 DOI: 10.1182/Blood.V124.21.2916.2916  0.555
2013 Zhao JL, Rao DS, O'Connell RM, Garcia-Flores Y, Baltimore D. MicroRNA-146a acts as a guardian of the quality and longevity of hematopoietic stem cells in mice. Elife. 2: e00537. PMID 23705069 DOI: 10.7554/Elife.00537  0.446
2013 Hu R, Wallace J, Dahlem TJ, Grunwald DJ, O'Connell RM. Targeting human microRNA genes using engineered Tal-effector nucleases (TALENs). Plos One. 8: e63074. PMID 23667577 DOI: 10.1371/Journal.Pone.0063074  0.315
2013 Hu R, O'Connell RM. MicroRNA control in the development of systemic autoimmunity. Arthritis Research & Therapy. 15: 202. PMID 23379780 DOI: 10.1186/Ar4131  0.369
2012 Huffaker TB, Hu R, Runtsch MC, Bake E, Chen X, Zhao J, Round JL, Baltimore D, O'Connell RM. Epistasis between microRNAs 155 and 146a during T cell-mediated antitumor immunity. Cell Reports. 2: 1697-709. PMID 23200854 DOI: 10.1016/J.Celrep.2012.10.025  0.529
2012 Hu R, O'Connell RM. MiR-23b is a safeguard against autoimmunity. Nature Medicine. 18: 1009-10. PMID 22772548 DOI: 10.1038/Nm.2849  0.345
2012 O'Connell RM. MicroRNAs function on a new level. Blood. 119: 3875-6. PMID 22538495 DOI: 10.1182/Blood-2012-02-410977  0.327
2012 Chaudhuri AA, So AY, Mehta A, Minisandram A, Sinha N, Jonsson VD, Rao DS, O'Connell RM, Baltimore D. Oncomir miR-125b regulates hematopoiesis by targeting the gene Lin28A. Proceedings of the National Academy of Sciences of the United States of America. 109: 4233-8. PMID 22366319 DOI: 10.1073/Pnas.1200677109  0.484
2012 O'Connell RM, Baltimore D. MicroRNAs and hematopoietic cell development. Current Topics in Developmental Biology. 99: 145-74. PMID 22365738 DOI: 10.1016/B978-0-12-387038-4.00006-9  0.497
2012 O'Connell RM, Rao DS, Baltimore D. microRNA regulation of inflammatory responses. Annual Review of Immunology. 30: 295-312. PMID 22224773 DOI: 10.1146/Annurev-Immunol-020711-075013  0.498
2012 Zhao JL, Ma C, O'Connell R, Rao DS, Heath J, Baltimore D. Single Cell Proteomics Reveals Novel Cytokine-Producing Function of Hematopoietic Stem and Progenitor Cells Blood. 120: 26-26. DOI: 10.1182/Blood.V120.21.26.26  0.438
2011 Chaudhuri AA, So AY, Sinha N, Gibson WS, Taganov KD, O'Connell RM, Baltimore D. MicroRNA-125b potentiates macrophage activation. Journal of Immunology (Baltimore, Md. : 1950). 187: 5062-8. PMID 22003200 DOI: 10.4049/Jimmunol.1102001  0.536
2011 O'Connell RM, Zhao JL, Rao DS. MicroRNA function in myeloid biology. Blood. 118: 2960-9. PMID 21725054 DOI: 10.1182/Blood-2011-03-291971  0.308
2011 Zhao JL, Rao DS, Boldin MP, Taganov KD, O'Connell RM, Baltimore D. NF-kappaB dysregulation in microRNA-146a-deficient mice drives the development of myeloid malignancies. Proceedings of the National Academy of Sciences of the United States of America. 108: 9184-9. PMID 21576471 DOI: 10.1073/Pnas.1105398108  0.519
2011 Pietras EM, Miller LS, Johnson CT, O'Connell RM, Dempsey PW, Cheng G. A MyD88-dependent IFNγR-CCR2 signaling circuit is required for mobilization of monocytes and host defense against systemic bacterial challenge. Cell Research. 21: 1068-79. PMID 21467996 DOI: 10.1038/Cr.2011.59  0.728
2010 O'Connell RM, Kahn D, Gibson WS, Round JL, Scholz RL, Chaudhuri AA, Kahn ME, Rao DS, Baltimore D. MicroRNA-155 promotes autoimmune inflammation by enhancing inflammatory T cell development. Immunity. 33: 607-19. PMID 20888269 DOI: 10.1016/J.Immuni.2010.09.009  0.511
2010 O'Connell RM, Balazs AB, Rao DS, Kivork C, Yang L, Baltimore D. Lentiviral vector delivery of human interleukin-7 (hIL-7) to human immune system (HIS) mice expands T lymphocyte populations. Plos One. 5: e12009. PMID 20700454 DOI: 10.1371/Journal.Pone.0012009  0.508
2010 O'Connell RM, Chaudhuri AA, Rao DS, Gibson WS, Balazs AB, Baltimore D. MicroRNAs enriched in hematopoietic stem cells differentially regulate long-term hematopoietic output. Proceedings of the National Academy of Sciences of the United States of America. 107: 14235-40. PMID 20660734 DOI: 10.1073/Pnas.1009798107  0.488
2010 Rao DS, O'Connell RM, Chaudhuri AA, Garcia-Flores Y, Geiger TL, Baltimore D. MicroRNA-34a perturbs B lymphocyte development by repressing the forkhead box transcription factor Foxp1. Immunity. 33: 48-59. PMID 20598588 DOI: 10.1016/J.Immuni.2010.06.013  0.483
2010 O'Connell RM, Rao DS, Chaudhuri AA, Baltimore D. Physiological and pathological roles for microRNAs in the immune system. Nature Reviews. Immunology. 10: 111-22. PMID 20098459 DOI: 10.1038/Nri2708  0.51
2010 Round JL, O'Connell RM, Mazmanian SK. Coordination of tolerogenic immune responses by the commensal microbiota. Journal of Autoimmunity. 34: J220-5. PMID 19963349 DOI: 10.1016/J.Jaut.2009.11.007  0.352
2009 O'Connell RM, Chaudhuri AA, Rao DS, Baltimore D. Inositol phosphatase SHIP1 is a primary target of miR-155. Proceedings of the National Academy of Sciences of the United States of America. 106: 7113-8. PMID 19359473 DOI: 10.1073/Pnas.0902636106  0.496
2009 Hwang S, Kim KS, Flano E, Wu TT, Tong LM, Park AN, Song MJ, Sanchez DJ, O'Connell RM, Cheng G, Sun R. Conserved herpesviral kinase promotes viral persistence by inhibiting the IRF-3-mediated type I interferon response. Cell Host & Microbe. 5: 166-78. PMID 19218087 DOI: 10.1016/J.Chom.2008.12.013  0.703
2009 Luo XM, Maarschalk E, O'Connell RM, Wang P, Yang L, Baltimore D. Engineering human hematopoietic stem/progenitor cells to produce a broadly neutralizing anti-HIV antibody after in vitro maturation to human B lymphocytes. Blood. 113: 1422-31. PMID 19059876 DOI: 10.1182/Blood-2008-09-177139  0.411
2008 Baltimore D, Boldin MP, O'Connell RM, Rao DS, Taganov KD. MicroRNAs: new regulators of immune cell development and function. Nature Immunology. 9: 839-45. PMID 18645592 DOI: 10.1038/Ni.F.209  0.514
2008 O'Connell RM, Rao DS, Chaudhuri AA, Boldin MP, Taganov KD, Nicoll J, Paquette RL, Baltimore D. Sustained expression of microRNA-155 in hematopoietic stem cells causes a myeloproliferative disorder. The Journal of Experimental Medicine. 205: 585-94. PMID 18299402 DOI: 10.1084/Jem.20072108  0.515
2008 Miller LS, Pietras EM, Uricchio LH, Hirano K, Rao S, Lin H, O'Connell RM, Iwakura Y, Cheung AL, Cheng G, Modlin RL. Inflammasome-mediated production of IL-1β is required for neutrophil recruitment against Staphylococcus aureus in vivo (Journal of Immunolgy (2007) 179 (6933-6942)) Journal of Immunology. 180: 665.  0.581
2007 Miller LS, Pietras EM, Uricchio LH, Hirano K, Rao S, Lin H, O'Connell RM, Iwakura Y, Cheung AL, Cheng G, Modlin RL. Inflammasome-mediated production of IL-1beta is required for neutrophil recruitment against Staphylococcus aureus in vivo. Journal of Immunology (Baltimore, Md. : 1950). 179: 6933-42. PMID 17982084 DOI: 10.4049/Jimmunol.179.10.6933  0.692
2007 O'Connell RM, Taganov KD, Boldin MP, Cheng G, Baltimore D. MicroRNA-155 is induced during the macrophage inflammatory response. Proceedings of the National Academy of Sciences of the United States of America. 104: 1604-9. PMID 17242365 DOI: 10.1073/Pnas.0610731104  0.656
2006 Chow EK, Castrillo A, Shahangian A, Pei L, O'Connell RM, Modlin RL, Tontonoz P, Cheng G. A role for IRF3-dependent RXRalpha repression in hepatotoxicity associated with viral infections. The Journal of Experimental Medicine. 203: 2589-602. PMID 17074929 DOI: 10.1084/Jem.20060929  0.774
2006 Miller LS, O'Connell RM, Gutierrez MA, Pietras EM, Shahangian A, Gross CE, Thirumala A, Cheung AL, Cheng G, Modlin RL. MyD88 mediates neutrophil recruitment initiated by IL-1R but not TLR2 activation in immunity against Staphylococcus aureus. Immunity. 24: 79-91. PMID 16413925 DOI: 10.1016/J.Immuni.2005.11.011  0.757
2005 Chow EK, O'connell RM, Schilling S, Wang XF, Fu XY, Cheng G. TLR agonists regulate PDGF-B production and cell proliferation through TGF-beta/type I IFN crosstalk. The Embo Journal. 24: 4071-81. PMID 16308570 DOI: 10.1038/Sj.Emboj.7600867  0.648
2005 O'Connell RM, Vaidya SA, Perry AK, Saha SK, Dempsey PW, Cheng G. Immune activation of type I IFNs by Listeria monocytogenes occurs independently of TLR4, TLR2, and receptor interacting protein 2 but involves TNFR-associated NF kappa B kinase-binding kinase 1. Journal of Immunology (Baltimore, Md. : 1950). 174: 1602-7. PMID 15661922 DOI: 10.4049/Jimmunol.174.3.1602  0.791
2005 O'Connell R, Saha S, Cheng G. Combating Bacterial Pathogens Through Host Defense Gene Programs Current Immunology Reviews. 1: 43-54. DOI: 10.2174/1573395052952950  0.63
2004 Zhai Y, Shen XD, O'Connell R, Gao F, Lassman C, Busuttil RW, Cheng G, Kupiec-Weglinski JW. Cutting edge: TLR4 activation mediates liver ischemia/reperfusion inflammatory response via IFN regulatory factor 3-dependent MyD88-independent pathway. Journal of Immunology (Baltimore, Md. : 1950). 173: 7115-9. PMID 15585830 DOI: 10.4049/Jimmunol.173.12.7115  0.592
2004 Joseph SB, Bradley MN, Castrillo A, Bruhn KW, Mak PA, Pei L, Hogenesch J, O'connell RM, Cheng G, Saez E, Miller JF, Tontonoz P. LXR-dependent gene expression is important for macrophage survival and the innate immune response. Cell. 119: 299-309. PMID 15479645 DOI: 10.1016/J.Cell.2004.09.032  0.62
2004 O'Connell RM, Saha SK, Vaidya SA, Bruhn KW, Miranda GA, Zarnegar B, Perry AK, Nguyen BO, Lane TF, Taniguchi T, Miller JF, Cheng G. Type I interferon production enhances susceptibility to Listeria monocytogenes infection. The Journal of Experimental Medicine. 200: 437-45. PMID 15302901 DOI: 10.1084/Jem.20040712  0.752
2004 Doyle SE, O'Connell RM, Miranda GA, Vaidya SA, Chow EK, Liu PT, Suzuki S, Suzuki N, Modlin RL, Yeh WC, Lane TF, Cheng G. Toll-like receptors induce a phagocytic gene program through p38. The Journal of Experimental Medicine. 199: 81-90. PMID 14699082 DOI: 10.1084/Jem.20031237  0.796
2003 Doyle SE, O'Connell R, Vaidya SA, Chow EK, Yee K, Cheng G. Toll-like receptor 3 mediates a more potent antiviral response than Toll-like receptor 4. Journal of Immunology (Baltimore, Md. : 1950). 170: 3565-71. PMID 12646618 DOI: 10.4049/Jimmunol.170.7.3565  0.794
2002 Doyle S, Vaidya S, O'Connell R, Dadgostar H, Dempsey P, Wu T, Rao G, Sun R, Haberland M, Modlin R, Cheng G. IRF3 mediates a TLR3/TLR4-specific antiviral gene program. Immunity. 17: 251-63. PMID 12354379 DOI: 10.1016/S1074-7613(02)00390-4  0.758
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