Donald M. Coen - Publications

Affiliations: 
Harvard University, Cambridge, MA, United States 
Area:
Molecular Biology, Biochemistry, Microbiology Biology

204 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2019 Patel CD, Backes IM, Taylor SA, Jiang Y, Marchant A, Pesola JM, Coen DM, Knipe DM, Ackerman ME, Leib DA. Maternal immunization confers protection against neonatal herpes simplex mortality and behavioral morbidity. Science Translational Medicine. 11. PMID 30971454 DOI: 10.1126/scitranslmed.aau6039  1
2019 Pan D, Li G, Morris-Love J, Qi S, Feng L, Mertens ME, Jurak I, Knipe DM, Coen DM. Herpes Simplex Virus 1 Lytic Infection Blocks MicroRNA (miRNA) Biogenesis at the Stage of Nuclear Export of Pre-miRNAs. Mbio. 10. PMID 30755517 DOI: 10.1128/mBio.02856-18  0.36
2018 Lee JS, Raja P, Pan D, Pesola JM, Coen DM, Knipe DM. CCCTC-Binding Factor Acts as a Heterochromatin Barrier on Herpes Simplex Viral Latent Chromatin and Contributes to Poised Latent Infection. Mbio. 9. PMID 29437926 DOI: 10.1128/mBio.02372-17  1
2018 Wilkie AR, Sharma M, Pesola JM, Ericsson M, Fernandez R, Coen DM. A role for myosin Va in human cytomegalovirus nuclear egress. Journal of Virology. PMID 29298889 DOI: 10.1128/JVI.01849-17  1
2016 Pan D, Pesola JM, Li G, McCarron S, Coen DM. Mutations Inactivating Herpes Simplex Virus-1 miR-H2 Do Not Detectably Increase ICP0 Gene Expression in Infected Cultured Cells or Mouse Trigeminal Ganglia. Journal of Virology. PMID 27847363 DOI: 10.1128/JVI.02001-16  1
2016 Wilkie AR, Lawler JL, Coen DM. A Role for Nuclear F-Actin Induction in Human Cytomegalovirus Nuclear Egress. Mbio. 7. PMID 27555312 DOI: 10.1128/mBio.01254-16  1
2016 Rosato PC, Katzenell S, Pesola JM, North B, Coen DM, Leib DA. Neuronal IFN signaling is dispensable for the establishment of HSV-1 latency. Virology. 497: 323-327. PMID 27518540 DOI: 10.1016/j.virol.2016.06.016  1
2016 Polachek WS, Moshrif HF, Franti M, Coen DM, Sreenu VB, Strang BL. High Throughput siRNA Screening Identifies Phosphatidylinositol 3-kinase Class II Alpha as Important for Production of Human Cytomegalovirus Virions. Journal of Virology. PMID 27412598 DOI: 10.1128/JVI.01134-16  0.4
2016 Raja P, Lee JS, Pan D, Pesola JM, Coen DM, Knipe DM. A Herpesviral Lytic Protein Regulates the Structure of Latent Viral Chromatin. Mbio. 7. PMID 27190217 DOI: 10.1128/mBio.00633-16  1
2016 Sharma M, Kamil JP, Coen DM. Preparation of the Human Cytomegalovirus Nuclear Egress Complex and Associated Proteins. Methods in Enzymology. 569: 517-26. PMID 26778574 DOI: 10.1016/bs.mie.2015.08.020  1
2015 Colgrove RC, Liu X, Griffiths A, Raja P, Deluca NA, Newman RM, Coen DM, Knipe DM. History and genomic sequence analysis of the herpes simplex virus 1 KOS and KOS1.1 sub-strains. Virology. 487: 215-221. PMID 26547038 DOI: 10.1016/j.virol.2015.09.026  1
2015 Lye MF, Sharma M, El Omari K, Filman DJ, Schuermann JP, Hogle JM, Coen DM. Unexpected features and mechanism of heterodimer formation of a herpesvirus nuclear egress complex. The Embo Journal. PMID 26511021 DOI: 10.15252/embj.201592651  1
2015 Leigh KE, Sharma M, Mansueto MS, Boeszoermenyi A, Filman DJ, Hogle JM, Wagner G, Coen DM, Arthanari H. Structure of a herpesvirus nuclear egress complex subunit reveals an interaction groove that is essential for viral replication. Proceedings of the National Academy of Sciences of the United States of America. 112: 9010-5. PMID 26150520 DOI: 10.1073/pnas.1511140112  0.4
2015 Sharma M, Bender BJ, Kamil JP, Lye MF, Pesola JM, Reim NI, Hogle JM, Coen DM. Human cytomegalovirus UL97 phosphorylates the viral nuclear egress complex. Journal of Virology. 89: 523-34. PMID 25339763 DOI: 10.1128/JVI.02426-14  1
2014 Chen H, Beardsley GP, Coen DM. Mechanism of ganciclovir-induced chain termination revealed by resistant viral polymerase mutants with reduced exonuclease activity. Proceedings of the National Academy of Sciences of the United States of America. 111: 17462-7. PMID 25422422 DOI: 10.1073/pnas.1405981111  1
2014 Bender BJ, Coen DM, Strang BL. Dynamic and nucleolin-dependent localization of human cytomegalovirus UL84 to the periphery of viral replication compartments and nucleoli. Journal of Virology. 88: 11738-47. PMID 25078694 DOI: 10.1128/JVI.01889-14  1
2014 Yan Z, Bryant KF, Gregory SM, Angelova M, Dreyfus DH, Zhao XZ, Coen DM, Burke TR, Knipe DM. HIV integrase inhibitors block replication of alpha-, beta-, and gammaherpesviruses. Mbio. 5: e01318-14. PMID 24987091 DOI: 10.1128/mBio.01318-14  1
2014 Sharma M, Coen DM. Comparison of effects of inhibitors of viral and cellular protein kinases on human cytomegalovirus disruption of nuclear lamina and nuclear egress. Journal of Virology. 88: 10982-5. PMID 24965476 DOI: 10.1128/JVI.01391-14  1
2014 Pan D, Flores O, Umbach JL, Pesola JM, Bentley P, Rosato PC, Leib DA, Cullen BR, Coen DM. A neuron-specific host microRNA targets herpes simplex virus-1 ICP0 expression and promotes latency. Cell Host & Microbe. 15: 446-56. PMID 24721573 DOI: 10.1016/j.chom.2014.03.004  1
2014 Terrell SL, Pesola JM, Coen DM. Roles of conserved residues within the pre-NH2-terminal domain of herpes simplex virus 1 DNA polymerase in replication and latency in mice. The Journal of General Virology. 95: 940-7. PMID 24413420 DOI: 10.1099/vir.0.061903-0  1
2014 Jurak I, Hackenberg M, Kim JY, Pesola JM, Everett RD, Preston CM, Wilson AC, Coen DM. Expression of herpes simplex virus 1 microRNAs in cell culture models of quiescent and latent infection. Journal of Virology. 88: 2337-9. PMID 24307587 DOI: 10.1128/JVI.03486-13  1
2014 Sharma M, Kamil JP, Coughlin M, Reim NI, Coen DM. Human cytomegalovirus UL50 and UL53 recruit viral protein kinase UL97, not protein kinase C, for disruption of nuclear lamina and nuclear egress in infected cells. Journal of Virology. 88: 249-62. PMID 24155370 DOI: 10.1128/JVI.02358-13  1
2014 Pan D, Kaye SB, Hopkins M, Kirwan R, Hart IJ, Coen DM. Common and new acyclovir resistant herpes simplex virus-1 mutants causing bilateral recurrent herpetic keratitis in an immunocompetent patient. The Journal of Infectious Diseases. 209: 345-9. PMID 23945375 DOI: 10.1093/infdis/jit437  1
2013 Reim NI, Kamil JP, Wang D, Lin A, Sharma M, Ericsson M, Pesola JM, Golan DE, Coen DM. Inactivation of retinoblastoma protein does not overcome the requirement for human cytomegalovirus UL97 in lamina disruption and nuclear egress. Journal of Virology. 87: 5019-27. PMID 23427156 DOI: 10.1128/JVI.00007-13  1
2013 Cliffe AR, Coen DM, Knipe DM. Kinetics of facultative heterochromatin and polycomb group protein association with the herpes simplex viral genome during establishment of latent infection. Mbio. 4. PMID 23322639 DOI: 10.1128/mBio.00590-12  1
2012 Weller SK, Coen DM. Herpes simplex viruses: mechanisms of DNA replication. Cold Spring Harbor Perspectives in Biology. 4: a013011. PMID 22952399 DOI: 10.1101/cshperspect.a013011  1
2012 Pan D, Coen DM. Net -1 frameshifting on a noncanonical sequence in a herpes simplex virus drug-resistant mutant is stimulated by nonstop mRNA. Proceedings of the National Academy of Sciences of the United States of America. 109: 14852-7. PMID 22927407 DOI: 10.1073/pnas.1206582109  1
2012 Terrell SL, Coen DM. The pre-NH(2)-terminal domain of the herpes simplex virus 1 DNA polymerase catalytic subunit is required for efficient viral replication. Journal of Virology. 86: 11057-65. PMID 22875965 DOI: 10.1128/JVI.01034-12  1
2012 Strang BL, Bender BJ, Sharma M, Pesola JM, Sanders RL, Spector DH, Coen DM. A mutation deleting sequences encoding the amino terminus of human cytomegalovirus UL84 impairs interaction with UL44 and capsid localization. Journal of Virology. 86: 11066-77. PMID 22855486 DOI: 10.1128/JVI.01379-12  1
2012 Jurak I, Silverstein LB, Sharma M, Coen DM. Herpes simplex virus is equipped with RNA- and protein-based mechanisms to repress expression of ATRX, an effector of intrinsic immunity. Journal of Virology. 86: 10093-102. PMID 22787211 DOI: 10.1128/JVI.00930-12  1
2012 Strang BL, Boulant S, Kirchhausen T, Coen DM. Host cell nucleolin is required to maintain the architecture of human cytomegalovirus replication compartments. Mbio. 3. PMID 22318319 DOI: 10.1128/mBio.00301-11  1
2012 Pan D, Coen DM. Quantification and analysis of thymidine kinase expression from acyclovir-resistant G-string insertion and deletion mutants in herpes simplex virus-infected cells. Journal of Virology. 86: 4518-26. PMID 22301158 DOI: 10.1128/JVI.06995-11  1
2012 Strang BL, Boulant S, Chang L, Knipe DM, Kirchhausen T, Coen DM. Human cytomegalovirus UL44 concentrates at the periphery of replication compartments, the site of viral DNA synthesis. Journal of Virology. 86: 2089-95. PMID 22156516 DOI: 10.1128/JVI.06720-11  1
2011 Coen DM, Whitley RJ. Antiviral drugs and antiviral drug resistance. Current Opinion in Virology. 1: 545-7. PMID 22440912 DOI: 10.1016/j.coviro.2011.10.024  1
2011 Silva LA, Strang BL, Lin EW, Kamil JP, Coen DM. Sites and roles of phosphorylation of the human cytomegalovirus DNA polymerase subunit UL44. Virology. 417: 268-80. PMID 21784501 DOI: 10.1016/j.virol.2011.06.008  1
2011 Kramer MF, Jurak I, Pesola JM, Boissel S, Knipe DM, Coen DM. Herpes simplex virus 1 microRNAs expressed abundantly during latent infection are not essential for latency in mouse trigeminal ganglia. Virology. 417: 239-47. PMID 21782205 DOI: 10.1016/j.virol.2011.06.027  1
2011 Jurak I, Griffiths A, Coen DM. Mammalian alphaherpesvirus miRNAs. Biochimica Et Biophysica Acta. 1809: 641-53. PMID 21736960 DOI: 10.1016/j.bbagrm.2011.06.010  1
2011 Kamil JP, Coen DM. HATs on for drug resistance. Cell Host & Microbe. 9: 85-7. PMID 21320689 DOI: 10.1016/j.chom.2011.02.001  1
2011 Shogan B, Kruse L, Mulamba GB, Hu A, Coen DM. Virucidal activity of a GT-rich oligonucleotide against herpes simplex virus mediated by glycoprotein B (Journal of Virology (2006), 80, 10 (4740-4747)) Journal of Virology. 85: 1909. DOI: 10.1128/JVI.02534-10  1
2010 Silva LA, Loregian A, Pari GS, Strang BL, Coen DM. The carboxy-terminal segment of the human cytomegalovirus DNA polymerase accessory subunit UL44 is crucial for viral replication. Journal of Virology. 84: 11563-8. PMID 20739543 DOI: 10.1128/JVI.01033-10  1
2010 Tran K, Kamil JP, Coen DM, Spector DH. Inactivation and disassembly of the anaphase-promoting complex during human cytomegalovirus infection is associated with degradation of the APC5 and APC4 subunits and does not require UL97-mediated phosphorylation of Cdh1. Journal of Virology. 84: 10832-43. PMID 20686030 DOI: 10.1128/JVI.01260-10  1
2010 Gentry BG, Kamil JP, Coen DM, Zemlicka J, Drach JC. Stereoselective phosphorylation of cyclopropavir by pUL97 and competitive inhibition by maribavir. Antimicrobial Agents and Chemotherapy. 54: 3093-8. PMID 20547817 DOI: 10.1128/AAC.00468-10  1
2010 Strang BL, Geballe AP, Coen DM. Association of human cytomegalovirus proteins IRS1 and TRS1 with the viral DNA polymerase accessory subunit UL44. The Journal of General Virology. 91: 2167-75. PMID 20444996 DOI: 10.1099/vir.0.022640-0  1
2010 Strang BL, Coen DM. Interaction of the human cytomegalovirus uracil DNA glycosylase UL114 with the viral DNA polymerase catalytic subunit UL54. The Journal of General Virology. 91: 2029-33. PMID 20410316 DOI: 10.1099/vir.0.022160-0  1
2010 Jurak I, Kramer MF, Mellor JC, van Lint AL, Roth FP, Knipe DM, Coen DM. Numerous conserved and divergent microRNAs expressed by herpes simplex viruses 1 and 2. Journal of Virology. 84: 4659-72. PMID 20181707 DOI: 10.1128/JVI.02725-09  1
2010 Strang BL, Boulant S, Coen DM. Nucleolin associates with the human cytomegalovirus DNA polymerase accessory subunit UL44 and is necessary for efficient viral replication. Journal of Virology. 84: 1771-84. PMID 20007282 DOI: 10.1128/JVI.01510-09  1
2009 Kamil JP, Hume AJ, Jurak I, Münger K, Kalejta RF, Coen DM. Human papillomavirus 16 E7 inactivator of retinoblastoma family proteins complements human cytomegalovirus lacking UL97 protein kinase. Proceedings of the National Academy of Sciences of the United States of America. 106: 16823-8. PMID 19805380 DOI: 10.1073/pnas.0901521106  1
2009 Baltz JL, Filman DJ, Ciustea M, Silverman JE, Lautenschlager CL, Coen DM, Ricciardi RP, Hogle JM. The crystal structure of PF-8, the DNA polymerase accessory subunit from Kaposi's sarcoma-associated herpesvirus. Journal of Virology. 83: 12215-28. PMID 19759157 DOI: 10.1128/JVI.01158-09  1
2009 Jiang C, Komazin-Meredith G, Tian W, Coen DM, Hwang CB. Mutations that increase DNA binding by the processivity factor of herpes simplex virus affect virus production and DNA replication fidelity. Journal of Virology. 83: 7573-80. PMID 19474109 DOI: 10.1128/JVI.00193-09  1
2009 Strang BL, Sinigalia E, Silva LA, Coen DM, Loregian A. Analysis of the association of the human cytomegalovirus DNA polymerase subunit UL44 with the viral DNA replication factor UL84. Journal of Virology. 83: 7581-9. PMID 19457994 DOI: 10.1128/JVI.00663-09  1
2009 Hamirally S, Kamil JP, Ndassa-Colday YM, Lin AJ, Jahng WJ, Baek MC, Noton S, Silva LA, Simpson-Holley M, Knipe DM, Golan DE, Marto JA, Coen DM. Viral mimicry of Cdc2/cyclin-dependent kinase 1 mediates disruption of nuclear lamina during human cytomegalovirus nuclear egress. Plos Pathogens. 5: e1000275. PMID 19165338 DOI: 10.1371/journal.ppat.1000275  1
2009 Sam MD, Evans BT, Coen DM, Hogle JM. Biochemical, biophysical, and mutational analyses of subunit interactions of the human cytomegalovirus nuclear egress complex. Journal of Virology. 83: 2996-3006. PMID 19153235 DOI: 10.1128/JVI.02441-08  1
2009 Coen DM. Discovery and analysis of differentially expressed genes in single cells and cell populations Current Protocols in Molecular Biology. 25.0.1-25.0.2. DOI: 10.1002/0471142727.mb2500s87  1
2008 Sinigalia E, Alvisi G, Mercorelli B, Coen DM, Pari GS, Jans DA, Ripalti A, Palù G, Loregian A. Role of homodimerization of human cytomegalovirus DNA polymerase accessory protein UL44 in origin-dependent DNA replication in cells. Journal of Virology. 82: 12574-9. PMID 18842734 DOI: 10.1128/JVI.01193-08  1
2008 Bryant KF, Macari ER, Malik N, Boyce M, Yuan J, Coen DM. ICP34.5-dependent and -independent activities of salubrinal in herpes simplex virus-1 infected cells. Virology. 379: 197-204. PMID 18684481 DOI: 10.1016/j.virol.2008.06.028  1
2008 Komazin-Meredith G, Petrella RJ, Santos WL, Filman DJ, Hogle JM, Verdine GL, Karplus M, Coen DM. The human cytomegalovirus UL44 C clamp wraps around DNA. Structure (London, England : 1993). 16: 1214-25. PMID 18682223 DOI: 10.1016/j.str.2008.05.008  1
2008 Komazin-Meredith G, Mirchev R, Golan DE, van Oijen AM, Coen DM. Hopping of a processivity factor on DNA revealed by single-molecule assays of diffusion. Proceedings of the National Academy of Sciences of the United States of America. 105: 10721-6. PMID 18658237 DOI: 10.1073/pnas.0802676105  1
2008 Umbach JL, Kramer MF, Jurak I, Karnowski HW, Coen DM, Cullen BR. MicroRNAs expressed by herpes simplex virus 1 during latent infection regulate viral mRNAs. Nature. 454: 780-3. PMID 18596690 DOI: 10.1038/nature07103  1
2008 Hume AJ, Finkel JS, Kamil JP, Coen DM, Culbertson MR, Kalejta RF. Phosphorylation of retinoblastoma protein by viral protein with cyclin-dependent kinase function. Science (New York, N.Y.). 320: 797-9. PMID 18467589 DOI: 10.1126/science.1152095  1
2008 Komazin-Meredith G, Santos WL, Filman DJ, Hogle JM, Verdine GL, Coen DM. The positively charged surface of herpes simplex virus UL42 mediates DNA binding. The Journal of Biological Chemistry. 283: 6154-61. PMID 18178550 DOI: 10.1074/jbc.M708691200  1
2008 Bryant KF, Coen DM. Inhibition of translation by a short element in the 5' leader of the herpes simplex virus 1 DNA polymerase transcript. Journal of Virology. 82: 77-85. PMID 17959669 DOI: 10.1128/JVI.01484-07  1
2007 Jiang C, Hwang YT, Wang G, Randell JC, Coen DM, Hwang CB. Herpes simplex virus mutants with multiple substitutions affecting DNA binding of UL42 are impaired for viral replication and DNA synthesis. Journal of Virology. 81: 12077-9. PMID 17715219 DOI: 10.1128/JVI.01133-07  1
2007 Kamil JP, Coen DM. Human cytomegalovirus protein kinase UL97 forms a complex with the tegument phosphoprotein pp65. Journal of Virology. 81: 10659-68. PMID 17634236 DOI: 10.1128/JVI.00497-07  1
2007 Loregian A, Sinigalia E, Mercorelli B, Palù G, Coen DM. Binding parameters and thermodynamics of the interaction of the human cytomegalovirus DNA polymerase accessory protein, UL44, with DNA: implications for the processivity mechanism. Nucleic Acids Research. 35: 4779-91. PMID 17617644 DOI: 10.1093/nar/gkm506  1
2007 Dodson AW, Taylor TJ, Knipe DM, Coen DM. Inhibitors of the sodium potassium ATPase that impair herpes simplex virus replication identified via a chemical screening approach. Virology. 366: 340-8. PMID 17544048 DOI: 10.1016/j.virol.2007.05.001  1
2007 Besecker MI, Furness CL, Coen DM, Griffiths A. Expression of extremely low levels of thymidine kinase from an acyclovir-resistant herpes simplex virus mutant supports reactivation from latently infected mouse trigeminal ganglia. Journal of Virology. 81: 8356-60. PMID 17522225 DOI: 10.1128/JVI.00484-07  1
2007 Pesola JM, Coen DM. In vivo fitness and virulence of a drug-resistant herpes simplex virus 1 mutant. The Journal of General Virology. 88: 1410-4. PMID 17412967 DOI: 10.1099/vir.0.82787-0  1
2007 Jiang C, Hwang YT, Randell JC, Coen DM, Hwang CB. Mutations that decrease DNA binding of the processivity factor of the herpes simplex virus DNA polymerase reduce viral yield, alter the kinetics of viral DNA replication, and decrease the fidelity of DNA replication. Journal of Virology. 81: 3495-502. PMID 17229696 DOI: 10.1128/JVI.02359-06  1
2006 Kramer MF, Coen DM. Enzymatic amplification of DNA by PCR: standard procedures and optimization. Current Protocols in Cytometry / Editorial Board, J. Paul Robinson, Managing Editor ... [Et Al.]. Appendix 3K. PMID 18770830 DOI: 10.1002/0471142956.cya03ks37  1
2006 Griffiths A, Link MA, Furness CL, Coen DM. Low-level expression and reversion both contribute to reactivation of herpes simplex virus drug-resistant mutants with mutations on homopolymeric sequences in thymidine kinase. Journal of Virology. 80: 6568-74. PMID 16775343 DOI: 10.1128/JVI.00155-06  1
2006 Cui C, Griffiths A, Li G, Silva LM, Kramer MF, Gaasterland T, Wang XJ, Coen DM. Prediction and identification of herpes simplex virus 1-encoded microRNAs. Journal of Virology. 80: 5499-508. PMID 16699030 DOI: 10.1128/JVI.00200-06  1
2006 Shogan B, Kruse L, Mulamba GB, Hu A, Coen DM. Virucidal activity of a GT-rich oligonucleotide against herpes simplex virus mediated by glycoprotein B. Journal of Virology. 80: 4740-7. PMID 16641267 DOI: 10.1128/JVI.80.10.4740-4747.2006  1
2006 Loregian A, Coen DM. Selective anti-cytomegalovirus compounds discovered by screening for inhibitors of subunit interactions of the viral polymerase. Chemistry & Biology. 13: 191-200. PMID 16492567 DOI: 10.1016/j.chembiol.2005.12.002  1
2006 Appleton BA, Brooks J, Loregian A, Filman DJ, Coen DM, Hogle JM. Crystal structure of the cytomegalovirus DNA polymerase subunit UL44 in complex with the C terminus from the catalytic subunit. Differences in structure and function relative to unliganded UL44. The Journal of Biological Chemistry. 281: 5224-32. PMID 16371349 DOI: 10.1074/jbc.M506900200  1
2005 Pesola JM, Zhu J, Knipe DM, Coen DM. Herpes simplex virus 1 immediate-early and early gene expression during reactivation from latency under conditions that prevent infectious virus production. Journal of Virology. 79: 14516-25. PMID 16282451 DOI: 10.1128/JVI.79.23.14516-14525.2005  1
2005 Wang QY, Zhou C, Johnson KE, Colgrove RC, Coen DM, Knipe DM. Herpesviral latency-associated transcript gene promotes assembly of heterochromatin on viral lytic-gene promoters in latent infection. Proceedings of the National Academy of Sciences of the United States of America. 102: 16055-9. PMID 16247011 DOI: 10.1073/pnas.0505850102  1
2005 Bryant KF, Cox JC, Wang H, Hogle JM, Ellington AD, Coen DM. Binding of herpes simplex virus-1 US11 to specific RNA sequences. Nucleic Acids Research. 33: 6090-100. PMID 16246910 DOI: 10.1093/nar/gki919  1
2005 Randell JC, Komazin G, Jiang C, Hwang CB, Coen DM. Effects of substitutions of arginine residues on the basic surface of herpes simplex virus UL42 support a role for DNA binding in processive DNA synthesis. Journal of Virology. 79: 12025-34. PMID 16140778 DOI: 10.1128/JVI.79.18.12025-12034.2005  1
2005 Griffiths A, Coen DM. An unusual internal ribosome entry site in the herpes simplex virus thymidine kinase gene. Proceedings of the National Academy of Sciences of the United States of America. 102: 9667-72. PMID 15972803 DOI: 10.1073/pnas.0504132102  1
2005 Boyce M, Bryant KF, Jousse C, Long K, Harding HP, Scheuner D, Kaufman RJ, Ma D, Coen DM, Ron D, Yuan J. A selective inhibitor of eIF2alpha dephosphorylation protects cells from ER stress. Science (New York, N.Y.). 307: 935-9. PMID 15705855 DOI: 10.1126/science.1101902  1
2004 Cook WJ, Kramer MF, Walker RM, Burwell TJ, Holman HA, Coen DM, Knipe DM. Persistent expression of chemokine and chemokine receptor RNAs at primary and latent sites of herpes simplex virus 1 infection. Virology Journal. 1: 5. PMID 15507126 DOI: 10.1186/1743-422X-1-5  1
2004 Loregian A, Appleton BA, Hogle JM, Coen DM. Specific residues in the connector loop of the human cytomegalovirus DNA polymerase accessory protein UL44 are crucial for interaction with the UL54 catalytic subunit. Journal of Virology. 78: 9084-92. PMID 15308704 DOI: 10.1128/JVI.78.17.9084-9092.2004  1
2004 Appleton BA, Loregian A, Filman DJ, Coen DM, Hogle JM. The cytomegalovirus DNA polymerase subunit UL44 forms a C clamp-shaped dimer. Molecular Cell. 15: 233-44. PMID 15260974 DOI: 10.1016/j.molcel.2004.06.018  1
2004 Baek MC, Krosky PM, Pearson A, Coen DM. Phosphorylation of the RNA polymerase II carboxyl-terminal domain in human cytomegalovirus-infected cells and in vitro by the viral UL97 protein kinase. Virology. 324: 184-93. PMID 15183065 DOI: 10.1016/j.virol.2004.03.015  1
2004 Pilger BD, Cui C, Coen DM. Identification of a small molecule that inhibits herpes simplex virus DNA Polymerase subunit interactions and viral replication. Chemistry & Biology. 11: 647-54. PMID 15157875 DOI: 10.1016/j.chembiol.2004.01.018  1
2004 Randell JC, Coen DM. The herpes simplex virus processivity factor, UL42, binds DNA as a monomer. Journal of Molecular Biology. 335: 409-13. PMID 14672651 DOI: 10.1016/j.jmb.2003.10.064  1
2004 Chen SH, Pearson A, Coen DM, Chen SH. Failure of thymidine kinase-negative herpes simplex virus to reactivate from latency following efficient establishment. Journal of Virology. 78: 520-3. PMID 14671133 DOI: 10.1128/JVI.78.1.520-523.2004  1
2004 Loregian A, Appleton BA, Hogle JM, Coen DM. Residues of human cytomegalovirus DNA polymerase catalytic subunit UL54 that are necessary and sufficient for interaction with the accessory protein UL44. Journal of Virology. 78: 158-67. PMID 14671097 DOI: 10.1128/JVI.78.1.158-167.2004  1
2004 Pearson A, Knipe DM, Coen DM. ICP27 selectively regulates the cytoplasmic localization of a subset of viral transcripts in herpes simplex virus type 1-infected cells. Journal of Virology. 78: 23-32. PMID 14671084 DOI: 10.1128/JVI.78.1.23-32.2004  1
2003 Kramer MF, Cook WJ, Roth FP, Zhu J, Holman H, Knipe DM, Coen DM. Latent herpes simplex virus infection of sensory neurons alters neuronal gene expression. Journal of Virology. 77: 9533-41. PMID 12915567 DOI: 10.1128/JVI.77.17.9533-9541.2003  1
2003 Krosky PM, Baek MC, Jahng WJ, Barrera I, Harvey RJ, Biron KK, Coen DM, Sethna PB. The human cytomegalovirus UL44 protein is a substrate for the UL97 protein kinase. Journal of Virology. 77: 7720-7. PMID 12829811 DOI: 10.1128/JVI.77.14.7720-7727.2003  1
2003 Kramer M, Riley J, Spoering A, Coen D, Knipe D. Effect of immunization on herpes simplex virus type 1 latent infection in the trigeminal ganglion. Current Eye Research. 26: 185-94. PMID 12815546 DOI: 10.1076/ceyr.26.3.185.14891  1
2003 Coen DM, Schaffer PA. Antiherpesvirus drugs: a promising spectrum of new drugs and drug targets. Nature Reviews. Drug Discovery. 2: 278-88. PMID 12669027 DOI: 10.1038/nrd1065  1
2003 Griffiths A, Chen SH, Horsburgh BC, Coen DM. Translational compensation of a frameshift mutation affecting herpes simplex virus thymidine kinase is sufficient to permit reactivation from latency. Journal of Virology. 77: 4703-9. PMID 12663777 DOI: 10.1128/JVI.77.8.4703-4709.2003  1
2003 Griffiths A, Coen DM. High-frequency phenotypic reversion and pathogenicity of an acyclovir-resistant herpes simplex virus mutant. Journal of Virology. 77: 2282-6. PMID 12525666 DOI: 10.1128/JVI.77.3.2282-2286.2003  1
2003 Krosky PM, Baek MC, Coen DM. The human cytomegalovirus UL97 protein kinase, an antiviral drug target, is required at the stage of nuclear egress. Journal of Virology. 77: 905-14. PMID 12502806 DOI: 10.1128/JVI.77.2.905-914.2003  1
2002 Kramer MF, Coen DM. The polymerase chain reaction. Current Protocols in Protein Science / Editorial Board, John E. Coligan ... [Et Al.]. Appendix 4J. PMID 18429219 DOI: 10.1002/0471140864.psa04js29  1
2002 Baek MC, Krosky PM, Coen DM. Relationship between autophosphorylation and phosphorylation of exogenous substrates by the human cytomegalovirus UL97 protein kinase. Journal of Virology. 76: 11943-52. PMID 12414936 DOI: 10.1128/JVI.76.23.11943-11952.2002  1
2002 Pearson A, Coen DM. Identification, localization, and regulation of expression of the UL24 protein of herpes simplex virus type 1. Journal of Virology. 76: 10821-8. PMID 12368325 DOI: 10.1128/JVI.76.21.10821-10828.2002  1
2002 Baek MC, Krosky PM, He Z, Coen DM. Specific phosphorylation of exogenous protein and peptide substrates by the human cytomegalovirus UL97 protein kinase. Importance of the P+5 position. The Journal of Biological Chemistry. 277: 29593-9. PMID 12048183 DOI: 10.1074/jbc.M202312200  1
2002 Chen SH, Lee LY, Garber DA, Schaffer PA, Knipe DM, Coen DM. Neither LAT nor open reading frame P mutations increase expression of spliced or intron-containing ICP0 transcripts in mouse ganglia latently infected with herpes simplex virus. Journal of Virology. 76: 4764-72. PMID 11967293 DOI: 10.1128/JVI.76.10.4764-4772.2002  1
2001 Coen DM. Quantitation of rare DNAs by PCR. Current Protocols in Immunology / Edited by John E. Coligan ... [Et Al.]. Unit 10.21. PMID 18432686 DOI: 10.1002/0471142735.im1021s24  1
2001 Kramer MF, Coen DM. Enzymatic amplification of DNA by PCR: standard procedures and optimization. Current Protocols in Immunology / Edited by John E. Coligan ... [Et Al.]. Unit 10.20. PMID 18432685 DOI: 10.1002/0471142735.im1020s24  1
2001 Coen DM. Quantitation of rare DNAs by PCR. Current Protocols in Molecular Biology / Edited by Frederick M. Ausubel ... [Et Al.]. Unit 15.7. PMID 18265121 DOI: 10.1002/0471142727.mb1507s56  1
2001 Kramer MF, Coen DM. Enzymatic amplification of DNA by PCR: standard procedures and optimization. Current Protocols in Molecular Biology / Edited by Frederick M. Ausubel ... [Et Al.]. Unit 15.1. PMID 18265115 DOI: 10.1002/0471142727.mb1501s56  1
2001 Kramer MF, Coen DM. Enzymatic amplification of DNA by PCR: standard procedures and optimization. Current Protocols in Cell Biology / Editorial Board, Juan S. Bonifacino ... [Et Al.]. Appendix 3F. PMID 18228288 DOI: 10.1002/0471143030.cba03fs10  1
2001 Randell JC, Coen DM. Linear diffusion on DNA despite high-affinity binding by a DNA polymerase processivity factor. Molecular Cell. 8: 911-20. PMID 11684025 DOI: 10.1016/S1097-2765(01)00355-0  1
2001 Bridges KG, Chow CS, Coen DM. Identification of crucial hydrogen-bonding residues for the interaction of herpes simplex virus DNA polymerase subunits via peptide display, mutational, and calorimetric approaches Journal of Virology. 75: 4990-4998. PMID 11333878 DOI: 10.1128/JVI.75.11.4990-4998.2001  1
2001 Burkham J, Coen DM, Hwang CB, Weller SK. Interactions of herpes simplex virus type 1 with ND10 and recruitment of PML to replication compartments. Journal of Virology. 75: 2353-67. PMID 11160739 DOI: 10.1128/JVI.75.5.2353-2367.2001  1
2000 Chen SH, Garber DA, Schaffer PA, Knipe DM, Coen DM. Persistent elevated expression of cytokine transcripts in ganglia latently infected with herpes simplex virus in the absence of ganglionic replication or reactivation Virology. 278: 207-216. PMID 11112495 DOI: 10.1006/viro.2000.0643  1
2000 Zuccola HJ, Filman DJ, Coen DM, Hogle JM. The crystal structure of an unusual processivity factor, herpes simplex virus UL42, bound to the C terminus of its cognate polymerase. Molecular Cell. 5: 267-78. PMID 10882068  1
1999 Huang L, Ishii KK, Zuccola H, Gehring AM, Hwang CBC, Hogle J, Coen DM. The enzymological basis for resistance of herpesvirus DNA polymerase mutants to acyclovir: Relationship to the structure of α-like DNA polymerases Proceedings of the National Academy of Sciences of the United States of America. 96: 447-452. PMID 9892653 DOI: 10.1073/pnas.96.2.447  1
1999 Weisshart K, Chow CS, Coen DM. Herpes simplex virus processivity factor UL42 imparts increased DNA- binding specificity to the viral DNA polymerase and decreased dissociation from primer-template without reducing the elongation rate Journal of Virology. 73: 55-66. PMID 9847307  1
1998 Pelosi E, Rozenberg F, Coen DM, Tyler KL. A herpes simplex virus DNA polymerase mutation that specifically attenuates neurovirulence in mice Virology. 252: 364-372. PMID 9878615 DOI: 10.1006/viro.1998.9447  1
1998 Burkham J, Coen DM, Weller SK. ND10 protein PML is recruited to herpes simplex virus type 1 prereplicative sites and replication compartments in the presence of viral DNA polymerase. Journal of Virology. 72: 10100-7. PMID 9811750  1
1998 Hann LE, Cook WJ, Uprichard SL, Knipe DM, Coen DM. The role of herpes simplex virus ICP27 in the regulation of UL24 gene expression by differential polyadenylation Journal of Virology. 72: 7709-7714. PMID 9733806  1
1998 Horsburgh BC, Chen SH, Hu A, Mulamba GB, Burns WH, Coen DM. Recurrent acyclovir-resistant herpes simplex in an immunocompromised patient: Can strain differences compensate for loss of thymidine kinase in pathogenesis? Journal of Infectious Diseases. 178: 618-625. PMID 9728528  1
1998 Chen SH, Cook WJ, Grove KL, Coen DM. Human thymidine kinase can functionally replace herpes simplex virus type 1 thymidine kinase for viral replication in mouse sensory ganglia and reactivation from latency upon explant Journal of Virology. 72: 6710-6715. PMID 9658118  1
1998 Coen DM. The persistence of (HIV in) memory (T cells) Trends in Microbiology. 6: 129-130. PMID 9587186 DOI: 10.1016/S0966-842X(98)01232-3  1
1998 Mulamba GB, Hu A, Azad RF, Anderson KP, Coen DM. Human cytomegalovirus mutant with sequence-dependent resistance to the phosphorothioate oligonucleotide fomivirsen (ISIS 2922) Antimicrobial Agents and Chemotherapy. 42: 971-973. PMID 9559825  1
1998 Jacobson JG, Chen SH, Cook WJ, Kramer MF, Coen DM. Importance of the herpes simplex virus UL24 gene for productive ganglionic infection in mice Virology. 242: 161-169. PMID 9501052 DOI: 10.1006/viro.1997.9012  1
1998 Pelosi E, Mulamba GB, Coen DM. Penciclovir and pathogenesis phenotypes of drug-resistant Herpes simplex virus mutants Antiviral Research. 37: 17-28. PMID 9497069 DOI: 10.1016/S0166-3542(97)00054-5  1
1998 Kramer MF, Chen SH, Knipe DM, Coen DM. Accumulation of viral transcripts and DNA during establishment of latency by herpes simplex virus Journal of Virology. 72: 1177-1185. PMID 9445016  1
1997 Hwang YT, Liu BUY, Coen DM, Hwang CBC. Effects of mutations in the Exo III motif of the herpes simplex virus DNA polymerase gene on enzyme activities, viral replication, and replication fidelity Journal of Virology. 71: 7791-7798. PMID 9311864  1
1997 Chen SH, Kramer MF, Schaffer PA, Coen DM. A viral function represses accumulation of transcripts from productive- cycle genes in mouse ganglia latently infected with herpes simplex virus Journal of Virology. 71: 5878-5884. PMID 9223477  1
1997 He Z, He YS, Kim Y, Chu L, Ohmstede C, Biron KK, Coen DM. The human cytomegalovirus UL97 protein is a protein kinase that autophosphorylates on serines and threonines. Journal of Virology. 71: 405-11. PMID 8985364  1
1996 Coen DM. Wheel keeps turning for antiviral combination chemotherapy Trends in Microbiology. 4: 51-52. PMID 8820566 DOI: 10.1016/0966-842X(96)81509-5  1
1996 Coen DM. Antiviral drug resistance in herpes simplex virus Advances in Experimental Medicine and Biology. 394: 49-57. PMID 8815709  1
1996 Horsburgh BC, Kollmus H, Hauser H, Coen DM. Translational recoding induced by G-rich mRNA sequences that form unusual structures Cell. 86: 949-959. PMID 8808630 DOI: 10.1016/S0092-8674(00)80170-1  1
1996 Cook WJ, Coen DM. Temporal regulation of herpes simplex virus type 1 UL24 mRNA expression via differential polyadenylation Virology. 218: 204-213. PMID 8615023 DOI: 10.1006/viro.1996.0180  1
1996 Cook WJ, Wobbe KK, Böni J, Coen DM. Regulation of neighboring gene expression by the herpes simplex virus type 1 thymidine kinase gene Virology. 218: 193-203. PMID 8615022 DOI: 10.1006/viro.1996.0179  1
1995 Digard P, Bebrin WR, Coen DM. Mutational analysis of DNA polymerase substrate recognition and subunit interactions using herpes simplex virus as prototype Methods in Enzymology. 262: 303-322. PMID 8594357 DOI: 10.1016/0076-6879(95)62026-5  1
1995 Digard P, Williams KP, Hensley P, Brooks IS, Dahl CE, Coen DM. Specific inhibition of herpes simplex virus DNA polymerase by helical peptides corresponding to the subunit interface. Proceedings of the National Academy of Sciences of the United States of America. 92: 1456-60. PMID 7878000 DOI: 10.1073/pnas.92.5.1456  1
1995 Kramer MF, Coen DM. Quantification of transcripts from the ICP4 and thymidine kinase genes in mouse ganglia latently infected with herpes simplex virus Journal of Virology. 69: 1389-1399. PMID 7853471  1
1995 Jacobson J, Kramer M, Rozenberg F, Hu A, Coen DM. Synergistic effects on ganglionic herpes simplex virus infections by mutations or drugs that inhibit the viral polymerase and thymidine kinase Virology. 206: 263-268. PMID 7831780 DOI: 10.1016/S0042-6822(95)80041-7  1
1995 Cook WJ, Gu B, DeLuca NA, Moynihan EB, Coen DM. Induction of transcription by a viral regulatory protein depends on the relative strengths of functional TATA boxes Molecular and Cellular Biology. 15: 4998-5006. PMID 7651418  1
1995 Chow CS, Coen DM. Mutations that specifically impair the DNA binding activity of the herpes simplex virus protein UL42 Journal of Virology. 69: 6965-6971. PMID 7474115  1
1995 Coen DM. Resistance of herpes simplex virus to antiviral drugs Current Opinion in Infectious Diseases. 8: 489-492. DOI: 10.1097/00001432-199512000-00016  1
1995 Chiou HC, Kumura K, Hu A, Kerns KM, Coen DM. Penciclovir-resistance mutations in the herpes simplex virus DNA polymerase gene Antiviral Chemistry and Chemotherapy. 6: 281-288.  1
1994 Mineta T, Markert JM, Takamiya Y, Coen DM, Rabkin SD, Martuza RL. CNS tumor therapy by attenuated herpes simplex viruses. Gene Therapy. 1: S78. PMID 8542424  1
1994 Hwang CBC, Horsburgh B, Pelosi E, Roberts S, Digard P, Coen DM. A net +1 frameshift permits synthesis of thymidine kinase from a drug- resistant herpes simplex virus mutant Proceedings of the National Academy of Sciences of the United States of America. 91: 5461-5465. PMID 8202508 DOI: 10.1073/pnas.91.12.5461  1
1994 Weisshart K, Kuo AA, Hwang CBC, Kumura K, Coen DM. Structural and functional organization of herpes simplex virus DNA polymerase investigated by limited proteolysis Journal of Biological Chemistry. 269: 22788-22796. PMID 8077231  1
1994 Coen DM. Acyclovir-resistant, pathogenic herpesviruses Trends in Microbiology. 2: 481-485. PMID 7889324 DOI: 10.1016/0966-842X(94)90652-1  1
1993 Digard P, Chow CS, Pirrit L, Coen DM. Functional analysis of the herpes simplex virus UL42 protein Journal of Virology. 67: 1159-1168. PMID 8437207  1
1993 Wobbe KK, Digard P, Staknis D, Coen DM. Unusual regulation of expression of the herpes simplex virus DNA polymerase gene Journal of Virology. 67: 5419-5425. PMID 8394456  1
1993 Kosz-Vnenchak M, Jacobson J, Coen DM, Knipe DM. Evidence for a novel regulatory pathway for herpes simplex virus gene expression in trigeminal ganglion neurons Journal of Virology. 67: 5383-5393. PMID 8394454  1
1993 Markert JM, Malick A, Coen DM, Martuza RL. Reduction and elimination of encephalitis in an experimental glioma therapy model with attenuated herpes simplex mutants that retain susceptibility to acyclovir. Neurosurgery. 32: 597-603. PMID 8386343  1
1993 Sullivan V, Biron KK, Talarico C, Stanat SC, Davis M, Pozzi LM, Coen DM. A point mutation in the human cytomegalovirus DNA polymerase gene confers resistance to ganciclovir and phosphonylmethoxyalkyl derivatives Antimicrobial Agents and Chemotherapy. 37: 19-25. PMID 8381637  1
1993 Digard P, Bebrin WR, Weisshart K, Coen DM. The extreme C terminus of herpes simplex virus DNA polymerase is crucial for functional interaction with processivity factor UL42 and for viral replication Journal of Virology. 67: 398-406. PMID 8380085  1
1993 Cai W, Astor TL, Liptak LM, Cho C, Coen DM, Schaffer PA. The herpes simplex virus type 1 regulatory protein ICP0 enhances virus replication during acute infection and reactivation from latency Journal of Virology. 67: 7501-7512. PMID 8230470  1
1993 Garber DA, Beverley SM, Coen DM. Demonstration of circularization of herpes simplex virus DNA following infection using pulsed field gel electrophoresis Virology. 197: 459-462. PMID 8212585 DOI: 10.1006/viro.1993.1612  1
1993 Weisshart K, Kuo AA, Painter GR, Wright LL, Furman PA, Coen DM. Conformational changes induced in herpes simplex virus DNA polymerase upon DNA binding Proceedings of the National Academy of Sciences of the United States of America. 90: 1028-1032. PMID 7679215 DOI: 10.1073/pnas.90.3.1028  1
1992 Markert JM, Coen DM, Malick A, Mineta T, Martuza RL. Expanded spectrum of viral therapy in the treatment of nervous system tumors. Journal of Neurosurgery. 77: 590-4. PMID 1326612 DOI: 10.3171/jns.1992.77.4.0590  1
1992 Pelosi E, Hicks KA, Sacks SL, Coen DM. Heterogeneity of a herpes simplex virus clinical isolate exhibiting resistance to acyclovir and foscarnet. Advances in Experimental Medicine and Biology. 312: 151-8. PMID 1325102  1
1992 Sullivan V, Talarico CL, Stanat SC, Davis M, Coen DM, Biron KK. A protein kinase homologue controls phosphorylation of ganciclovir in human cytomegalovirus-infected cells Nature. 358: 162-164. PMID 1319560  1
1992 Hwang CBC, Ruffner KL, Coen DM. A point mutation within a distinct conserved region of the herpes simplex virus DNA polymerase gene confers drug resistance Journal of Virology. 66: 1774-1776. PMID 1310779  1
1991 Martuza RL, Malick A, Markert JM, Ruffner KL, Coen DM. Experimental therapy of human glioma by means of a genetically engineered virus mutant. Science (New York, N.Y.). 252: 854-6. PMID 1851332  1
1991 Bush M, Yager DR, Gao M, Weisshart K, Marcy AI, Coen DM, Knipe DM. Correct intranuclear localization of herpes simplex virus DNA polymerase requires the viral ICP8 DNA-binding protein. Journal of Virology. 65: 1082-9. PMID 1847437  1
1991 Imbalzano AN, Coen DM, DeLuca NA. Herpes simplex virus transactivator ICP4 operationally substitutes for the cellular transcription factor Sp1 for efficient expression of the viral thymidine kinase gene Journal of Virology. 65: 565-574. PMID 1846184  1
1991 Coen DM. The implications of resistance to antiviral agents for herpesvirus drug targets and drug therapy Antiviral Research. 15: 287-300. PMID 1659311 DOI: 10.1016/0166-3542(91)90010-O  1
1991 Sullivan V, Coen DM. Isolation of foscarnet-resistant human cytomegalovirus patterns of resistance and sensitivity to other antiviral drugs Journal of Infectious Diseases. 164: 781-784. PMID 1654362  1
1991 Gibbs JS, Weisshart K, Digard P, DeBruynkops A, Knipe DM, Coen DM. Polymerization activity of an α-like DNA polymerase requires a conserved 3'-5' exonuclease active site Molecular and Cellular Biology. 11: 4786-4795. PMID 1652064  1
1990 Gottlieb J, Marcy AI, Coen DM, Challberg MD. The herpes simplex virus type 1 UL42 gene product: a subunit of DNA polymerase that functions to increase processivity. Journal of Virology. 64: 5976-87. PMID 2173776  1
1990 Marcy AI, Hwang CBC, Ruffner KL, Coen DM. Engineered herpes simplex virus DNA polymerase point mutations: The most highly conserved region shared among α-like DNA polymerases is involved in substrate recognition Journal of Virology. 64: 5883-5890. PMID 2173770  1
1990 Koz-Vnenchak M, Coen DM, Knipe DM. Restricted expression of herpes simplex virus lytic genes during establishment of latent infection by thymidine kinase-negative mutant viruses Journal of Virology. 64: 5396-5402. PMID 2170678  1
1990 Digard P, Coen DM. A novel functional domain of an α-like DNA polymerase: The binding site on the herpes simplex virus polymerase for the viral UL42 protein Journal of Biological Chemistry. 265: 17393-17396. PMID 2170378  1
1990 Leib DA, Ruffner KL, Hildebrand C, Schaffer PA, Wright GE, Coen DM. Specific inhibitors of herpes simplex virus thymidine kinase diminish reactivation of latent virus from explanted murine ganglia. Antimicrobial Agents and Chemotherapy. 34: 1285-6. PMID 2168150  1
1990 Katz JP, Bodin ET, Coen DM. Quantitative polymerase chain reaction analysis of herpes simplex virus DNA in ganglia of mice infected with replication-incompetent mutants Journal of Virology. 64: 4288-4295. PMID 2166818  1
1990 Marcy AI, Yager DR, Coen DM. Isolation and characterization of herpes simplex virus mutants containing engineered mutations at the DNA polymerase locus. Journal of Virology. 64: 2208-16. PMID 2157881  1
1990 Marcy AL, Olivo PD, Challberg MD, Coen DM. Enzymatic activities of overexpressed herpes simplex virus DNA polymerase purified from recombinant baculovirus-infected insect cells Nucleic Acids Research. 18: 1207-1215. PMID 2157192 DOI: 10.1093/nar/18.5.1207  1
1990 Yager DR, Marcy AI, Coen DM. Translational regulation of herpes simplex virus DNA polymerase. Journal of Virology. 64: 2217-25. PMID 1691312  1
1989 Sacks SL, Wanklin RJ, Reece DE, Hicks KA, Tyler KL, Coen DM. Progressive esophagitis from acyclovir-resistant herpes simplex. Clinical roles for DNA polymerase mutants and viral heterogeneity? Annals of Internal Medicine. 111: 893-9. PMID 2554768  1
1989 Jacobson JG, Leib DA, Goldstein DJ, Bogard CL, Schaffer PA, Weller SK, Coen DM. A herpes simplex virus ribonucleotide reductase deletion mutant is defective for productive acute and reactivatable latent infections of mice and for replication in mouse cells. Virology. 173: 276-83. PMID 2554573 DOI: 10.1016/0042-6822(89)90244-4  1
1989 Coen DM, Goldstein DJ, Weller SK. Herpes simplex virus ribonucleotide reductase mutants are hypersensitive to acyclovir Antimicrobial Agents and Chemotherapy. 33: 1395-1399. PMID 2552912  1
1989 Boni J, Coen DM. Examination of the roles of transcription factor sp1-binding sites and an octamer motif in trans induction of the herpes simplex virus thymidine kinase gene Journal of Virology. 63: 4088-4092. PMID 2548017  1
1989 Coen DM, Kosz-Vnenchak M, Jacobson JG, Leib DA, Bogard CL, Schaffer PA, Tyler KL, Knipe DM. Thymidine kinase-negative herpes simplex virus mutants establish latency in mouse trigeminal ganglia but do not reactivate. Proceedings of the National Academy of Sciences of the United States of America. 86: 4736-40. PMID 2543985  1
1989 Leib DA, Bogard CL, Kosz-Vnenchak M, Hicks KA, Coen DM, Knipe DM, Schaffer PA. A deletion mutant of the latency-associated transcript of herpes simplex virus type 1 reactivates from the latent state with reduced frequency. Journal of Virology. 63: 2893-900. PMID 2542601  1
1989 Jacobson JG, Martin SL, Coen DM. A conserved open reading frame that overlaps the herpes simplex virus thymidine kinase gene is important for viral growth in cell culture Journal of Virology. 63: 1839-1843. PMID 2538662  1
1989 Coen DM, Irmiere AF, Jacobson JG, Kerns KM. Low levels of herpes simplex virus thymidine-thymidylate kinase are not limiting for sensitivity to certain antiviral drugs or for latency in a mouse model Virology. 168: 221-231. PMID 2536980 DOI: 10.1016/0042-6822(89)90261-4  1
1989 Irmiere AF, Manos MM, Jacobson JG, Gibbs JS, Coen DM. Effect of an amber mutation in the herpes simplex virus thymidine kinase gene on polypeptide synthesis and stability Virology. 168: 210-220. PMID 2536979 DOI: 10.1016/0042-6822(89)90260-2  1
1989 Leib DA, Coen DM, Bogard CL, Hicks KA, Yager DR, Knipe DM, Tyler KL, Schaffer PA. Immediate-early regulatory gene mutants define different stages in the establishment and reactivation of herpes simplex virus latency. Journal of Virology. 63: 759-68. PMID 2536101  1
1988 Gibbs JS, Chiou HC, Bastow KF, Cheng YC, Coen DM. Identification of amino acids in herpes simplex virus DNA polymerase involved in substrate and drug recognition Proceedings of the National Academy of Sciences of the United States of America. 85: 6672-6676. PMID 2842788  1
1988 Yager DR, Coen DM. Analysis of the transcript of the herpes simplex virus DNA polymerase gene provides evidence that polymerase expression is inefficient at the level of translation. Journal of Virology. 62: 2007-15. PMID 2835506  1
1986 Coen DM. General aspects of virus drug resistance with special reference to herpes simplex virus Journal of Antimicrobial Chemotherapy. 18: 1-10. PMID 3025148  1
1986 Chiou HC, Kerns KM, Coen DM. Mutation within the herpes simplex virus DNA polymerase gene conferring resistance to (R)-9-(3,4-dihydroxybutyl)guanine Antimicrobial Agents and Chemotherapy. 30: 502-504. PMID 3022642  1
1986 Biron KK, Fyfe JA, Stanat SC, Leslie LK, Sorrell JB, Lambe CU, Coen DM. A human cytomegalovirus mutant resistant to the nucleoside analog 9-{[2-hydroxy-1-(hydroxymethyl)ethoxy]methyl}guanine (BW B759U) induces reduced levels of BW B759U triphosphate Proceedings of the National Academy of Sciences of the United States of America. 83: 8769-8773. PMID 3022304 DOI: 10.1073/pnas.83.22.8769  1
1986 Coen DM, Weinheimer SP, McKnight SL. A genetic approach to promoter recognition during trans induction of viral gene expression. Science (New York, N.Y.). 234: 53-9. PMID 3018926  1
1986 Field HJ, Coen DM. Pathogenicity of herpes simplex virus mutants containing drug resistance mutations in the viral DNA polymerase gene Journal of Virology. 60: 286-289. PMID 3018291  1
1986 Hall JD, Gibbs JS, Coen DM, Mount DW. Structural organization and unusual codon usage in the DNA polymerase gene from herpes simplex virus type 1. Dna (Mary Ann Liebert, Inc.). 5: 281-8. PMID 3017656  1
1985 Graves BJ, Eisenberg SP, Coen DM, McKnight SL. Alternate utilization of two regulatory domains within the Moloney murine sarcoma virus long terminal repeat. Molecular and Cellular Biology. 5: 1959-68. PMID 3018540  1
1985 Eisenberg SP, Coen DM, McKnight SL. Promoter domains required for expression of plasmid-borne copies of the herpes simplex virus thymidine kinase gene in virus-infected mouse fibroblasts and microinjected frog oocytes. Molecular and Cellular Biology. 5: 1940-7. PMID 3018538  1
1985 Gibbs JS, Chiou HC, Hall JD, Mount DW, Retondo MJ, Weller SK, Coen DM. Sequence and mapping analyses of the herpes simplex virus DNA polymerase gene predict a C-terminal substrate binding domain. Proceedings of the National Academy of Sciences of the United States of America. 82: 7969-73. PMID 2999787 DOI: 10.1073/pnas.82.23.7969  1
1985 Chiou HC, Weller SK, Coen DM. Mutations in the herpes simplex virus major DNA-binding protein gene leading to altered sensitivity to DNA polymerase inhibitors Virology. 145: 213-226. PMID 2992151 DOI: 10.1016/0042-6822(85)90155-2  1
1985 Coen DM, Fleming HE, Leslie LK, Retondo MJ. Sensitivity of arabinosyladenine-resistant mutants of herpes simplex virus to other antiviral drugs and mapping of drug hypersensitivity mutations to the DNA polymerase locus Journal of Virology. 53: 477-488. PMID 2982032  1
1984 Schaffer PA, Weller SK, Pancake BA, Coen DM. Genetics of herpes simplex virus Journal of Investigative Dermatology. 83. PMID 6330220  1
1984 Coen DM, Aschman DP, Gelep PT, Retondo MJ, Weller SK, Schaffer PA. Fine mapping and molecular cloning of mutations in the herpes simplex virus DNA polymerase locus Journal of Virology. 49: 236-247. PMID 6317891  1
1984 Fleming HE, Coen DM. Herpes simplex virus mutants resistant to arabinosyladenine in the presence of deoxycoformycin Antimicrobial Agents and Chemotherapy. 26: 382-387. PMID 6095755  1
1983 Weller SK, Aschman DP, Sacks WR, Coen DM, Schaffer PA. Genetic analysis of temperature-sensitive mutants of HSV-1: The combined use of complementation and physical mapping for cistron assignment Virology. 130: 290-305. PMID 6316633 DOI: 10.1016/0042-6822(83)90084-3  1
1983 Coen DM, Furman PA, Aschman DP, Schaffer PA. Mutations in the herpes simplex virus DNA polymerase gene conferring hypersensitivity to aphidicolin Nucleic Acids Research. 11: 5287-5297. PMID 6308578 DOI: 10.1093/nar/11.15.5287  1
1982 Coen DM, Klein R, Crumpacker CS. Acyclovir-resistant herpes simplex virus New England Journal of Medicine. 307: 681-683. PMID 6287259  1
1982 Coen DM, Schaffer PA, Furman PA, Keller PM, CLAIR MHS. Biochemical and genetic analysis of acyclovir-resistant mutants of herpes simplex virus type 1 The American Journal of Medicine. 73: 351-360. PMID 6285722 DOI: 10.1016/0002-9343(82)90122-X  1
1982 Coen DM, Furman PA, Gelep PT, Schaffer PA. Mutations in the herpes simplex virus DNA polymerase gene can confer resistance to 9-β-D-arabinofuranosyladenine Journal of Virology. 41: 909-918. PMID 6284981  1
1981 Furman PA, Coen DM, St. Clair MH, Schaffer PA. Acyclovir-resistant mutants of herpes simplex virus type 1 express altered DNA polymerase or reduced acyclovir phosphorylating activities Journal of Virology. 40: 936-941. PMID 6275127  1
1980 Coen DM, Schaffer PA. Two distinct loci confer resistance to acycloguanosine in herpes simplex virus type 1 Proceedings of the National Academy of Sciences of the United States of America. 77: 2265-2269. PMID 6246531  1
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