Edward Pearce - Publications

Cornell University, Ithaca, NY, United States 
Immunology, Microbiology Biology

65 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2015 Monin L, Griffiths KL, Lam WY, Gopal R, Kang DD, Ahmed M, Rajamanickam A, Cruz-Lagunas A, Zúñiga J, Babu S, Kolls JK, Mitreva M, Rosa BA, Ramos-Payan R, Morrison TE, ... ... Pearce EJ, et al. Helminth-induced arginase-1 exacerbates lung inflammation and disease severity in tuberculosis. The Journal of Clinical Investigation. PMID 26571397 DOI: 10.1172/JCI77378  0.88
2015 Murray PJ, Rathmell J, Pearce E. SnapShot: Immunometabolism. Cell Metabolism. 22: 190-190.e1. PMID 26154058 DOI: 10.1016/j.cmet.2015.06.014  0.88
2015 Tussiwand R, Everts B, Grajales-Reyes GE, Kretzer NM, Iwata A, Bagaitkar J, Wu X, Wong R, Anderson DA, Murphy TL, Pearce EJ, Murphy KM. Klf4 expression in conventional dendritic cells is required for T helper 2 cell responses. Immunity. 42: 916-28. PMID 25992862 DOI: 10.1016/j.immuni.2015.04.017  0.88
2015 Fairfax KC, Everts B, Amiel E, Smith AM, Schramm G, Haas H, Randolph GJ, Taylor JJ, Pearce EJ. IL-4-secreting secondary T follicular helper (Tfh) cells arise from memory T cells, not persisting Tfh cells, through a B cell-dependent mechanism. Journal of Immunology (Baltimore, Md. : 1950). 194: 2999-3010. PMID 25712216 DOI: 10.4049/jimmunol.1401225  0.88
2014 Amiel E, Everts B, Fritz D, Beauchamp S, Ge B, Pearce EL, Pearce EJ. Mechanistic target of rapamycin inhibition extends cellular lifespan in dendritic cells by preserving mitochondrial function. Journal of Immunology (Baltimore, Md. : 1950). 193: 2821-30. PMID 25108022 DOI: 10.4049/jimmunol.1302498  0.88
2014 Huang SC, Everts B, Ivanova Y, O'Sullivan D, Nascimento M, Smith AM, Beatty W, Love-Gregory L, Lam WY, O'Neill CM, Yan C, Du H, Abumrad NA, Urban JF, Artyomov MN, ... Pearce EL, ... ... Pearce EJ, et al. Cell-intrinsic lysosomal lipolysis is essential for alternative activation of macrophages. Nature Immunology. 15: 846-55. PMID 25086775 DOI: 10.1038/ni.2956  0.88
2014 Gautier EL, Ivanov S, Williams JW, Huang SC, Marcelin G, Fairfax K, Wang PL, Francis JS, Leone P, Wilson DB, Artyomov MN, Pearce EJ, Randolph GJ. Gata6 regulates aspartoacylase expression in resident peritoneal macrophages and controls their survival. The Journal of Experimental Medicine. 211: 1525-31. PMID 25024137 DOI: 10.1084/jem.20140570  0.88
2014 O'Sullivan D, van der Windt GJ, Huang SC, Curtis JD, Chang CH, Buck MD, Qiu J, Smith AM, Lam WY, DiPlato LM, Hsu FF, Birnbaum MJ, Pearce EJ, Pearce EL. Memory CD8(+) T cells use cell-intrinsic lipolysis to support the metabolic programming necessary for development. Immunity. 41: 75-88. PMID 25001241 DOI: 10.1016/j.immuni.2014.06.005  0.88
2014 Everts B, Amiel E, Huang SC, Smith AM, Chang CH, Lam WY, Redmann V, Freitas TC, Blagih J, van der Windt GJ, Artyomov MN, Jones RG, Pearce EL, Pearce EJ. TLR-driven early glycolytic reprogramming via the kinases TBK1-IKKÉ› supports the anabolic demands of dendritic cell activation. Nature Immunology. 15: 323-32. PMID 24562310 DOI: 10.1038/ni.2833  0.88
2013 van der Windt GJ, O'Sullivan D, Everts B, Huang SC, Buck MD, Curtis JD, Chang CH, Smith AM, Ai T, Faubert B, Jones RG, Pearce EJ, Pearce EL. CD8 memory T cells have a bioenergetic advantage that underlies their rapid recall ability. Proceedings of the National Academy of Sciences of the United States of America. 110: 14336-41. PMID 23940348 DOI: 10.1073/pnas.1221740110  0.88
2013 Taylor CM, Wang Q, Rosa BA, Huang SC, Powell K, Schedl T, Pearce EJ, Abubucker S, Mitreva M. Discovery of anthelmintic drug targets and drugs using chokepoints in nematode metabolic pathways. Plos Pathogens. 9: e1003505. PMID 23935495 DOI: 10.1371/journal.ppat.1003505  0.88
2013 Chang CH, Curtis JD, Maggi LB, Faubert B, Villarino AV, O'Sullivan D, Huang SC, van der Windt GJ, Blagih J, Qiu J, Weber JD, Pearce EJ, Jones RG, Pearce EL. Posttranscriptional control of T cell effector function by aerobic glycolysis. Cell. 153: 1239-51. PMID 23746840 DOI: 10.1016/j.cell.2013.05.016  0.88
2013 Pearce EJ. Parasitology: Rejuvenation through stem cells. Nature. 494: 438-9. PMID 23426259 DOI: 10.1038/nature11953  0.88
2013 McCarthy SA, Mufson RA, Pearce EJ, Rathmell JC, Howcroft TK. Metabolic reprogramming of the immune response in the tumor microenvironment. Cancer Biology & Therapy. 14: 315-8. PMID 23358474 DOI: 10.4161/cbt.23616  0.88
2012 Huang SC, Freitas TC, Amiel E, Everts B, Pearce EL, Lok JB, Pearce EJ. Fatty acid oxidation is essential for egg production by the parasitic flatworm Schistosoma mansoni. Plos Pathogens. 8: e1002996. PMID 23133378 DOI: 10.1371/journal.ppat.1002996  0.88
2012 Perona-Wright G, Kohlmeier JE, Bassity E, Freitas TC, Mohrs K, Cookenham T, Situ H, Pearce EJ, Woodland DL, Mohrs M. Persistent loss of IL-27 responsiveness in CD8+ memory T cells abrogates IL-10 expression in a recall response. Proceedings of the National Academy of Sciences of the United States of America. 109: 18535-40. PMID 23091017 DOI: 10.1073/pnas.1119133109  0.88
2012 Everts B, Hussaarts L, Driessen NN, Meevissen MH, Schramm G, van der Ham AJ, van der Hoeven B, Scholzen T, Burgdorf S, Mohrs M, Pearce EJ, Hokke CH, Haas H, Smits HH, Yazdanbakhsh M. Schistosome-derived omega-1 drives Th2 polarization by suppressing protein synthesis following internalization by the mannose receptor. The Journal of Experimental Medicine. 209: 1753-67, S1. PMID 22966004 DOI: 10.1084/jem.20111381  0.88
2012 Shao H, Li X, Nolan TJ, Massey HC, Pearce EJ, Lok JB. Transposon-mediated chromosomal integration of transgenes in the parasitic nematode Strongyloides ratti and establishment of stable transgenic lines. Plos Pathogens. 8: e1002871. PMID 22912584 DOI: 10.1371/journal.ppat.1002871  0.88
2012 Amiel E, Everts B, Freitas TC, King IL, Curtis JD, Pearce EL, Pearce EJ. Inhibition of mechanistic target of rapamycin promotes dendritic cell activation and enhances therapeutic autologous vaccination in mice. Journal of Immunology (Baltimore, Md. : 1950). 189: 2151-8. PMID 22826320 DOI: 10.4049/jimmunol.1103741  0.88
2012 Pearce EJ, Caspar P, Grzych JM, Lewis FA, Sher A. Pillars article: downregulation of Th1 cytokine production accompanies induction of Th2 responses by a parasitic helminth, Schistosoma mansoni. J. Exp. Med. 1991. 173: 159-166. Journal of Immunology (Baltimore, Md. : 1950). 189: 1104-11. PMID 22815380  0.88
2012 Everts B, Amiel E, van der Windt GJ, Freitas TC, Chott R, Yarasheski KE, Pearce EL, Pearce EJ. Commitment to glycolysis sustains survival of NO-producing inflammatory dendritic cells. Blood. 120: 1422-31. PMID 22786879 DOI: 10.1182/blood-2012-03-419747  0.88
2012 Fairfax KC, Amiel E, King IL, Freitas TC, Mohrs M, Pearce EJ. IL-10R blockade during chronic schistosomiasis mansoni results in the loss of B cells from the liver and the development of severe pulmonary disease. Plos Pathogens. 8: e1002490. PMID 22291593 DOI: 10.1371/journal.ppat.1002490  0.88
2012 van der Windt GJ, Everts B, Chang CH, Curtis JD, Freitas TC, Amiel E, Pearce EJ, Pearce EL. Mitochondrial respiratory capacity is a critical regulator of CD8+ T cell memory development. Immunity. 36: 68-78. PMID 22206904 DOI: 10.1016/j.immuni.2011.12.007  0.88
2011 Li X, Shao H, Junio A, Nolan TJ, Massey HC, Pearce EJ, Viney ME, Lok JB. Transgenesis in the parasitic nematode Strongyloides ratti. Molecular and Biochemical Parasitology. 179: 114-9. PMID 21723330 DOI: 10.1016/j.molbiopara.2011.06.002  0.88
2010 Tran MH, Freitas TC, Cooper L, Gaze S, Gatton ML, Jones MK, Lovas E, Pearce EJ, Loukas A. Suppression of mRNAs encoding tegument tetraspanins from Schistosoma mansoni results in impaired tegument turnover. Plos Pathogens. 6: e1000840. PMID 20419145 DOI: 10.1371/journal.ppat.1000840  0.88
2010 Krawczyk CM, Holowka T, Sun J, Blagih J, Amiel E, DeBerardinis RJ, Cross JR, Jung E, Thompson CB, Jones RG, Pearce EJ. Toll-like receptor-induced changes in glycolytic metabolism regulate dendritic cell activation. Blood. 115: 4742-9. PMID 20351312 DOI: 10.1182/blood-2009-10-249540  0.88
2009 Maizels RM, Pearce EJ, Artis D, Yazdanbakhsh M, Wynn TA. Regulation of pathogenesis and immunity in helminth infections. The Journal of Experimental Medicine. 206: 2059-66. PMID 19770272 DOI: 10.1084/jem.20091903  0.88
2009 Perrigoue JG, Saenz SA, Siracusa MC, Allenspach EJ, Taylor BC, Giacomin PR, Nair MG, Du Y, Zaph C, van Rooijen N, Comeau MR, Pearce EJ, Laufer TM, Artis D. MHC class II-dependent basophil-CD4+ T cell interactions promote T(H)2 cytokine-dependent immunity. Nature Immunology. 10: 697-705. PMID 19465906 DOI: 10.1038/ni.1740  0.88
2009 Glatman Zaretsky A, Taylor JJ, King IL, Marshall FA, Mohrs M, Pearce EJ. T follicular helper cells differentiate from Th2 cells in response to helminth antigens. The Journal of Experimental Medicine. 206: 991-9. PMID 19380637 DOI: 10.1084/jem.20090303  0.88
2009 Nair MG, Du Y, Perrigoue JG, Zaph C, Taylor JJ, Goldschmidt M, Swain GP, Yancopoulos GD, Valenzuela DM, Murphy A, Karow M, Stevens S, Pearce EJ, Artis D. Alternatively activated macrophage-derived RELM-{alpha} is a negative regulator of type 2 inflammation in the lung. The Journal of Experimental Medicine. 206: 937-52. PMID 19349464 DOI: 10.1084/jem.20082048  0.88
2009 Taylor JJ, Krawczyk CM, Mohrs M, Pearce EJ. Th2 cell hyporesponsiveness during chronic murine schistosomiasis is cell intrinsic and linked to GRAIL expression. The Journal of Clinical Investigation. 119: 1019-28. PMID 19258704 DOI: 10.1172/JCI36534  0.88
2008 Krawczyk CM, Sun J, Pearce EJ. Th2 differentiation is unaffected by Jagged2 expression on dendritic cells. Journal of Immunology (Baltimore, Md. : 1950). 180: 7931-7. PMID 18523256  0.88
2008 Hotez PJ, Brindley PJ, Bethony JM, King CH, Pearce EJ, Jacobson J. Helminth infections: the great neglected tropical diseases. The Journal of Clinical Investigation. 118: 1311-21. PMID 18382743 DOI: 10.1172/JCI34261  0.88
2007 Pearce EJ. Worms tame mast cells. Nature Medicine. 13: 1288-9. PMID 17987024 DOI: 10.1038/nm1107-1288  0.88
2007 Morales ME, Mann VH, Kines KJ, Gobert GN, Fraser MJ, Kalinna BH, Correnti JM, Pearce EJ, Brindley PJ. piggyBac transposon mediated transgenesis of the human blood fluke, Schistosoma mansoni. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. 21: 3479-89. PMID 17586730 DOI: 10.1096/fj.07-8726com  0.88
2007 Krawczyk CM, Shen H, Pearce EJ. Memory CD4 T cells enhance primary CD8 T-cell responses. Infection and Immunity. 75: 3556-60. PMID 17438031 DOI: 10.1128/IAI.00086-07  0.88
2007 Krawczyk CM, Shen H, Pearce EJ. Functional plasticity in memory T helper cell responses. Journal of Immunology (Baltimore, Md. : 1950). 178: 4080-8. PMID 17371962  0.88
2007 Perrigoue JG, Li J, Zaph C, Goldschmidt M, Scott P, de Sauvage FJ, Pearce EJ, Ghilardi N, Artis D. IL-31-IL-31R interactions negatively regulate type 2 inflammation in the lung. The Journal of Experimental Medicine. 204: 481-7. PMID 17353366 DOI: 10.1084/jem.20061791  0.88
2007 Ekkens MJ, Shedlock DJ, Jung E, Troy A, Pearce EL, Shen H, Pearce EJ. Th1 and Th2 cells help CD8 T-cell responses Infection and Immunity. 75: 2291-2296. PMID 17325050 DOI: 10.1128/IAI.01328-06  0.88
2007 Brindley PJ, Pearce EJ. Genetic manipulation of schistosomes. International Journal For Parasitology. 37: 465-73. PMID 17280677 DOI: 10.1016/j.ijpara.2006.12.012  0.88
2006 Pearce EJ. An increased understanding of T-cell responses during helminth infections Parasite Immunology. 28: 239. DOI: 10.1111/j.1365-3024.2006.00885.x  0.88
2005 Pearce EJ. Priming of the immune response by schistosome eggs Parasite Immunology. 27: 265-270. PMID 16138847 DOI: 10.1111/j.1365-3024.2005.00765.x  0.88
2003 Pearce EJ. Progress towards a vaccine for schistosomiasis. Acta Tropica. 86: 309-13. PMID 12745147 DOI: 10.1016/S0001-706X(03)00062-7  0.88
2003 Straw AD, MacDonald AS, Denkers EY, Pearce EJ. CD154 plays a central role in regulating dendritic cell activation during infections that induce Th1 or Th2 responses. Journal of Immunology (Baltimore, Md. : 1950). 170: 727-34. PMID 12517934  0.88
2003 La Flamme AC, MacDonald AS, Huxtable CR, Carroll M, Pearce EJ. Lack of C3 affects Th2 response development and the sequelae of chemotherapy in schistosomiasis. Journal of Immunology (Baltimore, Md. : 1950). 170: 470-6. PMID 12496433  0.52
2002 La Flamme AC, Scott P, Pearce EJ. Schistosomiasis delays lesion resolution during Leishmania major infection by impairing parasite killing by macrophages. Parasite Immunology. 24: 339-45. PMID 12164819  0.52
2002 McGonigle S, Loschiavo M, Pearce EJ. 14-3-3 proteins in Schistosoma mansoni; identification of a second epsilon isoform. International Journal For Parasitology. 32: 685-93. PMID 12062487  0.48
2002 MacDonald AS, Patton EA, La Flamme AC, Araujo MI, Huxtable CR, Bauman B, Pearce EJ. Impaired Th2 development and increased mortality during Schistosoma mansoni infection in the absence of CD40/CD154 interaction. Journal of Immunology (Baltimore, Md. : 1950). 168: 4643-9. PMID 11971013  0.88
2002 Beall MJ, Pearce EJ. Transforming growth factor-beta and insulin-like signalling pathways in parasitic helminths. International Journal For Parasitology. 32: 399-404. PMID 11849636 DOI: 10.1016/S0020-7519(01)00348-4  0.88
2002 McGonigle S, Beall MJ, Pearce EJ. Eukaryotic initiation factor 2 alpha subunit associates with TGF beta receptors and 14-3-3 epsilon and acts as a modulator of the TGF beta response. Biochemistry. 41: 579-87. PMID 11781097 DOI: 10.1021/bi011407z  0.88
2002 Patton EA, La Flamme AC, Pedras-Vasoncelos JA, Pearce EJ. Central role for interleukin-4 in regulating nitric oxide-mediated inhibition of T-cell proliferation and gamma interferon production in schistosomiasis. Infection and Immunity. 70: 177-84. PMID 11748180 DOI: 10.1128/IAI.70.1.177-184.2002  0.88
2001 La Flamme AC, Patton EA, Pearce EJ. Role of gamma interferon in the pathogenesis of severe schistosomiasis in interleukin-4-deficient mice. Infection and Immunity. 69: 7445-52. PMID 11705919 DOI: 10.1128/IAI.69.12.7445-7452.2001  0.88
2001 Beall MJ, Pearce EJ. Human transforming growth factor-beta activates a receptor serine/threonine kinase from the intravascular parasite Schistosoma mansoni. The Journal of Biological Chemistry. 276: 31613-9. PMID 11406634 DOI: 10.1074/jbc.M104685200  0.88
2001 McGonigle S, Feeney EL, Beall MJ, Pearce EJ. SIP, a novel SH3 domain-containing protein, interacts with Schistosoma mansoni receptor kinase 1. Molecular and Biochemical Parasitology. 114: 119-23. PMID 11356521 DOI: 10.1016/S0166-6851(01)00232-8  0.88
2001 McGonigle S, Beall MJ, Feeney EL, Pearce EJ. Conserved role for 14-3-3epsilon downstream of type I TGFbeta receptors. Febs Letters. 490: 65-9. PMID 11172812 DOI: 10.1016/S0014-5793(01)02133-0  0.88
2001 La Flamme AC, Patton EA, Bauman B, Pearce EJ. IL-4 plays a crucial role in regulating oxidative damage in the liver during schistosomiasis. Journal of Immunology (Baltimore, Md. : 1950). 166: 1903-11. PMID 11160238  0.88
2001 Patton EA, Brunet LR, La Flamme AC, Pedras-Vasconcelos J, Kopf M, Pearce EJ. Severe schistosomiasis in the absence of interleukin-4 (IL-4) is IL-12 independent. Infection and Immunity. 69: 589-92. PMID 11119559 DOI: 10.1128/IAI.69.1.589-592.2001  0.88
2000 Beall MJ, McGonigle S, Pearce EJ. Functional conservation of Schistosoma mansoni Smads in TGF-beta signaling. Molecular and Biochemical Parasitology. 111: 131-42. PMID 11087923 DOI: 10.1016/S0166-6851(00)00307-8  0.88
1999 Dunne DW, Pearce EJ. Immunology of hepatosplenic schistosomiasis mansoni: A human perspective Microbes and Infection. 1: 553-560. PMID 10603572 DOI: 10.1016/S1286-4579(99)80095-1  0.88
1995 Sabin EA, Pearce EJ. Early IL-4 production by non-CD4+ cells at the site of antigen deposition predicts the development of a T helper 2 cell response to Schistosoma mansoni eggs Journal of Immunology. 155: 4844-4853. PMID 7594487  0.88
1993 Pearce EJ. Schistosomiasis. Proselytizing with immunity Nature. 363: 19-20. PMID 8097563 DOI: 10.1038/363019a0  0.88
1993 Vella AT, Pearce EJ. CD4+ T-cell receptor Vβ usage during the immune response to Schistosoma mansoni Infection and Immunity. 61: 5381-5383. PMID 7901168  0.88
1993 Pearce EJ. Proselytizing with immunity Nature. 363: 19-20.  0.88
1992 Pearce E, Appleton J. Production of immunomodulatory neuropeptides by Schistosoma mansoni Parasitology Today. 8: 353-354. DOI: 10.1016/0169-4758(92)90161-T  0.88
1985 Lanar D, Pearce E, Sher A. Expression vector cloning of two Schistosoma mansoni genes encoding proteins recognized by immune mouse antibodies Federation Proceedings. 44.  0.88
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