D L. Brautigan - Publications

University of Virginia, Charlottesville, VA 
Cell Biology, Microbiology Biology

204 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2024 Limerick A, McCabe EA, Turner JS, Kuang KW, Brautigan DL, Hao Y, Chu C, Fu SH, Ahmadi S, Xu W, Fu Z. An epilepsy-associated CILK1 variant compromises KATNIP regulation and impairs primary cilia and Hedgehog signaling. Biorxiv : the Preprint Server For Biology. PMID 38798407 DOI: 10.1101/2024.05.14.594243  0.321
2023 Turner JS, McCabe EA, Kuang KW, Gailey CD, Brautigan DL, Limerick A, Wang EX, Fu Z. The Scaffold Protein KATNIP Enhances CILK1 Control of Primary Cilia. Molecular and Cellular Biology. 43: 472-480. PMID 37665596 DOI: 10.1080/10985549.2023.2246870  0.399
2022 Brautigan DL. Phosphorylase Phosphatase and Flash Activation of Skeletal Muscle Glycogen Phosphorylase - A Tribute to Edmond H. Fischer. Iubmb Life. PMID 36239169 DOI: 10.1002/iub.2683  0.33
2022 Wang EX, Turner JS, Brautigan DL, Fu Z. Modulation of Primary Cilia by Alvocidib Inhibition of CILK1. International Journal of Molecular Sciences. 23. PMID 35897693 DOI: 10.3390/ijms23158121  0.333
2021 Brautigan DL, Farrington C, Narla G. Targeting protein phosphatase PP2A for cancer therapy: development of allosteric pharmaceutical agents. Clinical Science (London, England : 1979). 135: 1545-1556. PMID 34192314 DOI: 10.1042/CS20201367  0.357
2020 Gailey CD, Wang EJ, Jin L, Ahmadi S, Brautigan DL, Li X, Xu W, Scott MM, Fu Z. Phosphosite T674A mutation in kinesin family member 3A fails to reproduce tissue and ciliary defects characteristic of CILK1 loss of function. Developmental Dynamics : An Official Publication of the American Association of Anatomists. PMID 32935890 DOI: 10.1002/Dvdy.252  0.375
2020 Leonard D, Huang W, Izadmehr S, O'Connor CM, Wiredja DD, Wang Z, Zaware N, Chen Y, Schlatzer DM, Kiselar J, Vasireddi N, Schüchner S, Perl AL, Galsky MD, Xu W, ... Brautigan DL, et al. Selective PP2A Enhancement through Biased Heterotrimer Stabilization. Cell. PMID 32315618 DOI: 10.1016/J.Cell.2020.03.038  0.418
2020 Wang EJ, Gailey CD, Brautigan DL, Fu Z. Functional Alterations in Ciliogenesis-Associated Kinase 1 (CILK1) that Result from Mutations Linked to Juvenile Myoclonic Epilepsy. Cells. 9. PMID 32178256 DOI: 10.3390/Cells9030694  0.417
2020 Heo J, Larner JM, Brautigan DL. Protein kinase CK2 phosphorylation of SAPS3 subunit increases PP6 phosphatase activity with Aurora A kinase. The Biochemical Journal. PMID 31904830 DOI: 10.1042/Bcj20190740  0.546
2019 Biswas K, Sarkar S, Said N, Brautigan DL, Larner JM. Aurora B kinase promotes CHIP-dependent degradation of HIF1a in prostate cancer cells. Molecular Cancer Therapeutics. PMID 31848297 DOI: 10.1158/1535-7163.Mct-19-0777  0.364
2019 Dziegielewski J, Bońkowska MA, Poniecka EA, Heo J, Du K, Crittenden RB, Bender TP, Brautigan DL, Larner JM. Deletion of the SAPS1 subunit of protein phosphatase 6 in mice increases radiosensitivity and impairs the cellular DNA damage response. Dna Repair. 85: 102737. PMID 31751917 DOI: 10.1016/J.Dnarep.2019.102737  0.31
2019 O'Connor CM, Leonard D, Wiredja D, Avelar RA, Wang Z, Schlatzer D, Bryson B, Tokala E, Taylor SE, Upadhyay A, Sangodkar J, Gingras AC, Westermarck J, Xu W, DiFeo A, ... Brautigan DL, et al. Inactivation of PP2A by a recurrent mutation drives resistance to MEK inhibitors. Oncogene. PMID 31541192 DOI: 10.1038/S41388-019-1012-2  0.385
2019 Fu Z, Gailey CD, Wang EJ, Brautigan DL. Ciliogenesis associated kinase 1 (CILK1): targets and functions in various organ systems. Febs Letters. PMID 31506943 DOI: 10.1002/1873-3468.13600  0.412
2019 Oh YS, Wang EJ, Gailey CD, Brautigan DL, Allen BL, Fu Z. Ciliopathy-Associated Protein Kinase ICK Requires Its Non-Catalytic Carboxyl-Terminal Domain for Regulation of Ciliogenesis. Cells. 8. PMID 31277411 DOI: 10.3390/Cells8070677  0.51
2019 Luo C, Wu M, Su X, Yu F, Brautigan DL, Chen J, Zhou J. Protein phosphatase 1α interacts with a novel ciliary targeting sequence of polycystin-1 and regulates polycystin-1 trafficking. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. fj201900338R. PMID 31157564 DOI: 10.1096/Fj.201900338R  0.38
2018 Brautigan DL, Shenolikar S. Protein Serine/Threonine Phosphatases: Keys to Unlocking Regulators and Substrates. Annual Review of Biochemistry. 87: 921-964. PMID 29925267 DOI: 10.1146/Annurev-Biochem-062917-012332  0.442
2018 Tong Y, Park S, Wu D, Harris TE, Moskaluk CA, Brautigan DL, Fu Z. Modulation of GSK3β autoinhibition by Thr-7 and Thr-8. Febs Letters. PMID 29377106 DOI: 10.1002/1873-3468.12990  0.456
2018 McClinch K, A Avelar R, Callejas D, Izadmehr S, Wiredja D, Perl A, Sangodkar J, Kastrinsky DB, Schlatzer D, Cooper M, Kiselar J, Stachnik A, Yao S, Hoon D, McQuaid D, ... ... Brautigan DL, et al. Small molecule activators of protein phosphatase 2A for the treatment of castration-resistant prostate cancer. Cancer Research. PMID 29358171 DOI: 10.1158/0008-5472.Can-17-0123  0.361
2017 Ziembik MA, Bender TP, Larner JM, Brautigan DL. Functions of protein phosphatase-6 in NF-κB signaling and in lymphocytes. Biochemical Society Transactions. 45: 693-701. PMID 28620030 DOI: 10.1042/Bst20160169  0.417
2017 Larner JM, Sarkar S, Brautigan DL. Aurora Kinase A Promotes AR Degradation via the E3 Ligase CHIP. Molecular Cancer Research : McR. PMID 28536143 DOI: 10.1158/1541-7786.Mcr-17-0062  0.442
2017 Sangodkar J, Perl A, Tohme R, Kiselar J, Kastrinsky DB, Zaware N, Izadmehr S, Mazhar S, Wiredja DD, O'Connor CM, Hoon D, Dhawan NS, Schlatzer D, Yao S, Leonard D, ... Brautigan DL, et al. Activation of tumor suppressor protein PP2A inhibits KRAS-driven tumor growth. The Journal of Clinical Investigation. PMID 28504649 DOI: 10.1172/Jci89548  0.423
2017 Biswas K, Sarkar S, Du K, Brautigan DL, Abbas T, Larner JM. The E3 Ligase CHIP Mediates p21 Degradation to Maintain Radioresistance. Molecular Cancer Research : McR. PMID 28232384 DOI: 10.1158/1541-7786.Mcr-16-0466  0.376
2017 Shah M, Smolko CM, Kinicki S, Chapman ZD, Brautigan DL, Janes KA. Profiling Subcellular Protein Phosphatase Responses to Coxsackievirus B3 Infection of Cardiomyocytes. Molecular & Cellular Proteomics : McP. PMID 28174228 DOI: 10.1074/Mcp.O116.063487  0.438
2017 Tohme R, Sangodkar J, Kiselar J, Leonard D, O'Connor C, Gandhe S, Xu W, Brautigan D, Chance M, Ohlmeyer M, Narla G. Abstract 4173: Drug target mutations as a mechanism of acquired resistance to small molecules activators of protein phosphatase 2a Cancer Research. 77: 4173-4173. DOI: 10.1158/1538-7445.Am2017-4173  0.311
2016 Farinha CM, Swiatecka-Urban A, Brautigan DL, Jordan P. Regulatory Crosstalk by Protein Kinases on CFTR Trafficking and Activity. Frontiers in Chemistry. 4: 1. PMID 26835446 DOI: 10.3389/Fchem.2016.00001  0.433
2016 Sangodkar J, Tohme R, Kiselar J, Izadmehr S, Hoon D, Mazhar S, Perl A, Wiredja D, Schlatzer D, Yao S, Kastrinsky D, Sharma N, Brautigan D, Chance M, Borczuk A, et al. Abstract 3865: Therapeutic activation of protein phosphatase 2A for the treatment of lung cancer Cancer Research. 76: 3865-3865. DOI: 10.1158/1538-7445.Am2016-3865  0.374
2015 Griner EM, Dancik GM, Costello JC, Owens C, Guin S, Edwards MG, Brautigan DL, Theodorescu D. RhoC Is an Unexpected Target of RhoGDI2 in Prevention of Lung Colonization of Bladder Cancer. Molecular Cancer Research : McR. 13: 483-92. PMID 25516960 DOI: 10.1158/1541-7786.Mcr-14-0420  0.315
2014 Yan C, Liu D, Li L, Wempe MF, Guin S, Khanna M, Meier J, Hoffman B, Owens C, Wysoczynski CL, Nitz MD, Knabe WE, Ahmed M, Brautigan DL, Paschal BM, et al. Discovery and characterization of small molecules that target the GTPase Ral. Nature. 515: 443-7. PMID 25219851 DOI: 10.1038/Nature13713  0.315
2014 Hall EH, Liu Y, Xiao A, Shock L, Brautigan DL, Mayo MW, Adusumilli PS, Jones DR. Inhibition of breast cancer metastasis suppressor 1 promotes a mesenchymal phenotype in lung epithelial cells that express oncogenic K-RasV12 and loss of p53. Plos One. 9: e95869. PMID 24763730 DOI: 10.1371/Journal.Pone.0095869  0.311
2014 Luz S, Cihil KM, Brautigan DL, Amaral MD, Farinha CM, Swiatecka-Urban A. LMTK2-mediated phosphorylation regulates CFTR endocytosis in human airway epithelial cells. The Journal of Biological Chemistry. 289: 15080-93. PMID 24727471 DOI: 10.1074/Jbc.M114.563742  0.422
2014 Dziegielewska B, Brautigan DL, Larner JM, Dziegielewski J. T-type Ca2+ channel inhibition induces p53-dependent cell growth arrest and apoptosis through activation of p38-MAPK in colon cancer cells. Molecular Cancer Research : McR. 12: 348-58. PMID 24362252 DOI: 10.1158/1541-7786.Mcr-13-0485  0.315
2014 Sarkar S, Brautigan DL, Parsons SJ, Larner JM. Androgen receptor degradation by the E3 ligase CHIP modulates mitotic arrest in prostate cancer cells. Oncogene. 33: 26-33. PMID 23246967 DOI: 10.1038/Onc.2012.561  0.31
2013 Ohama T, Wang L, Griner EM, Brautigan DL. Protein Ser/Thr phosphatase-6 is required for maintenance of E-cadherin at adherens junctions. Bmc Cell Biology. 14: 42. PMID 24063632 DOI: 10.1186/1471-2121-14-42  0.426
2013 Korrodi-Gregório L, Ferreira M, Vintém AP, Wu W, Muller T, Marcus K, Vijayaraghavan S, Brautigan DL, da Cruz E Silva OA, Fardilha M, da Cruz E Silva EF. Identification and characterization of two distinct PPP1R2 isoforms in human spermatozoa. Bmc Cell Biology. 14: 15. PMID 23506001 DOI: 10.1186/1471-2121-14-15  0.473
2013 Wang L, Brautigan DL. α-SNAP inhibits AMPK signaling to reduce mitochondrial biogenesis and dephosphorylates Thr172 in AMPKα in vitro. Nature Communications. 4: 1559. PMID 23463002 DOI: 10.1038/Ncomms2565  0.373
2013 Valerie NC, Dziegielewska B, Hosing AS, Augustin E, Gray LS, Brautigan DL, Larner JM, Dziegielewski J. Inhibition of T-type calcium channels disrupts Akt signaling and promotes apoptosis in glioblastoma cells. Biochemical Pharmacology. 85: 888-97. PMID 23287412 DOI: 10.1016/J.Bcp.2012.12.017  0.301
2013 Brautigan DL. Protein Ser/Thr phosphatases--the ugly ducklings of cell signalling. The Febs Journal. 280: 324-45. PMID 22519956 DOI: 10.1111/J.1742-4658.2012.08609.X  0.507
2013 Griner EM, Churchill ME, Brautigan DL, Theodorescu D. PKCα phosphorylation of RhoGDI2 at Ser31 disrupts interactions with Rac1 and decreases GDI activity. Oncogene. 32: 1010-7. PMID 22469974 DOI: 10.1038/Onc.2012.124  0.519
2012 Holy M, Brautigan DL. Calyculin A from Discodermia calyx is a dual action toxin that blocks calcium influx and inhibits protein Ser/Thr phosphatases. Toxins. 4: 940-54. PMID 23162706 DOI: 10.3390/Toxins4100940  0.372
2012 Eto M, Brautigan DL. Endogenous inhibitor proteins that connect Ser/Thr kinases and phosphatases in cell signaling. Iubmb Life. 64: 732-9. PMID 22815089 DOI: 10.1002/Iub.1067  0.567
2012 Hosing AS, Valerie NC, Dziegielewski J, Brautigan DL, Larner JM. PP6 regulatory subunit R1 is bidentate anchor for targeting protein phosphatase-6 to DNA-dependent protein kinase. The Journal of Biological Chemistry. 287: 9230-9. PMID 22298787 DOI: 10.1074/Jbc.M111.333708  0.322
2012 Sun Y, Wang L, Jyothikumar V, Brautigan DL, Periasamy A. Characterizing the interactions between prolyl isomerase pin1 and phosphatase inhibitor-2 in living cells with FRET and FCS Progress in Biomedical Optics and Imaging - Proceedings of Spie. 8226. DOI: 10.1117/12.915315  0.38
2011 Edelson JR, Brautigan DL. The Discodermia calyx toxin calyculin a enhances cyclin D1 phosphorylation and degradation, and arrests cell cycle progression in human breast cancer cells. Toxins. 3: 105-19. PMID 22069692 DOI: 10.3390/Toxins3010105  0.37
2011 Martín-Montalvo A, González-Mariscal I, Padilla S, Ballesteros M, Brautigan DL, Navas P, Santos-Ocaña C. Respiratory-induced coenzyme Q biosynthesis is regulated by a phosphorylation cycle of Cat5p/Coq7p. The Biochemical Journal. 440: 107-14. PMID 21812761 DOI: 10.1042/Bj20101422  0.49
2011 Hall EH, Gurel V, Dahlberg AE, McMichael J, Brautigan DL. Inhibition of human breast cancer Matrigel invasion by Streptolysin O activation of the EGF receptor ErbB1. Cellular Signalling. 23: 1972-7. PMID 21787862 DOI: 10.1016/J.Cellsig.2011.07.007  0.376
2011 Sami F, Smet-Nocca C, Khan M, Landrieu I, Lippens G, Brautigan DL. Molecular basis for an ancient partnership between prolyl isomerase Pin1 and phosphatase inhibitor-2. Biochemistry. 50: 6567-78. PMID 21714498 DOI: 10.1021/Bi200553E  0.392
2011 Molhoek KR, Shada AL, Smolkin M, Chowbina S, Papin J, Brautigan DL, Slingluff CL. Comprehensive analysis of receptor tyrosine kinase activation in human melanomas reveals autocrine signaling through IGF-1R Melanoma Research. 21: 274-284. PMID 21654344 DOI: 10.1097/Cmr.0B013E328343A1D6  0.343
2011 Everett AD, Yang J, Rahman M, Dulloor P, Brautigan DL. Mitotic phosphorylation activates hepatoma-derived growth factor as a mitogen. Bmc Cell Biology. 12: 15. PMID 21489262 DOI: 10.1186/1471-2121-12-15  0.387
2010 Wang H, Owens C, Chandra N, Conaway MR, Brautigan DL, Theodorescu D. Phosphorylation of RalB is important for bladder cancer cell growth and metastasis. Cancer Research. 70: 8760-9. PMID 20940393 DOI: 10.1158/0008-5472.Can-10-0952  0.499
2010 Hall EH, Balsbaugh JL, Rose KL, Shabanowitz J, Hunt DF, Brautigan DL. Comprehensive analysis of phosphorylation sites in Tensin1 reveals regulation by p38MAPK. Molecular & Cellular Proteomics : McP. 9: 2853-63. PMID 20798394 DOI: 10.1074/Mcp.M110.003665  0.535
2010 Ohama T, Brautigan DL. Endotoxin conditioning induces VCP/p97-mediated and inducible nitric-oxide synthase-dependent Tyr284 nitration in protein phosphatase 2A. The Journal of Biological Chemistry. 285: 8711-8. PMID 20100830 DOI: 10.1074/Jbc.M109.099788  0.411
2010 Hans SK, Camara F, Altiti A, Martín-Montalvo A, Brautigan DL, Heimark D, Larner J, Grindrod S, Brown ML, Mootoo DR. Synthesis of C-glycoside analogues of beta-galactosamine-(1-->4)-3-O-methyl-D-chiro-inositol and assay as activator of protein phosphatases PDHP and PP2Calpha. Bioorganic & Medicinal Chemistry. 18: 1103-10. PMID 20079654 DOI: 10.1016/J.Bmc.2009.12.056  0.314
2010 Broglie P, Matsumoto K, Akira S, Brautigan DL, Ninomiya-Tsuji J. Transforming growth factor beta-activated kinase 1 (TAK1) kinase adaptor, TAK1-binding protein 2, plays dual roles in TAK1 signaling by recruiting both an activator and an inhibitor of TAK1 kinase in tumor necrosis factor signaling pathway. The Journal of Biological Chemistry. 285: 2333-9. PMID 19955178 DOI: 10.1074/Jbc.M109.090522  0.483
2010 Wang H, Wang X, Owens C, Chandra N, Conaway MR, Brautigan DL, Theodorescu D. Abstract 311: Phosphorylation of RalB by PKC regulates its intracellular distribution and promotion of bladder tumor growth Cancer Research. 70: 311-311. DOI: 10.1158/1538-7445.Am10-311  0.488
2009 Guergnon J, Derewenda U, Edelson JR, Brautigan DL. Mapping of protein phosphatase-6 association with its SAPS domain regulatory subunit using a model of helical repeats. Bmc Biochemistry. 10: 24. PMID 19835610 DOI: 10.1186/1471-2091-10-24  0.448
2009 Hall EH, Daugherty AE, Choi CK, Horwitz AF, Brautigan DL. Tensin1 requires protein phosphatase-1alpha in addition to RhoGAP DLC-1 to control cell polarization, migration, and invasion. The Journal of Biological Chemistry. 284: 34713-22. PMID 19826001 DOI: 10.1074/Jbc.M109.059592  0.377
2009 Morales-Johansson H, Puria R, Brautigan DL, Cardenas ME. Human protein phosphatase PP6 regulatory subunits provide Sit4-dependent and rapamycin-sensitive sap function in Saccharomyces cerevisiae. Plos One. 4: e6331. PMID 19621075 DOI: 10.1371/Journal.Pone.0006331  0.465
2009 Mi J, Dziegielewski J, Bolesta E, Brautigan DL, Larner JM. Activation of DNA-PK by ionizing radiation is mediated by protein phosphatase 6. Plos One. 4: e4395. PMID 19198648 DOI: 10.1371/Journal.Pone.0004395  0.347
2009 Mi J, Bolesta E, Brautigan DL, Larner JM. PP2A regulates ionizing radiation-induced apoptosis through Ser46 phosphorylation of p53. Molecular Cancer Therapeutics. 8: 135-40. PMID 19139122 DOI: 10.1158/1535-7163.Mct-08-0457  0.339
2008 Wang W, Brautigan DL. Phosphatase inhibitor 2 promotes acetylation of tubulin in the primary cilium of human retinal epithelial cells. Bmc Cell Biology. 9: 62. PMID 19036150 DOI: 10.1186/1471-2121-9-62  0.323
2008 Wang W, Stukenberg PT, Brautigan DL. Phosphatase inhibitor-2 balances protein phosphatase 1 and aurora B kinase for chromosome segregation and cytokinesis in human retinal epithelial cells. Molecular Biology of the Cell. 19: 4852-62. PMID 18716057 DOI: 10.1091/Mbc.E08-05-0460  0.45
2008 Ohama T, Okada M, Murata T, Brautigan DL, Hori M, Ozaki H. Sphingosine-1-phosphate enhances IL-1{beta}-induced COX-2 expression in mouse intestinal subepithelial myofibroblasts. American Journal of Physiology. Gastrointestinal and Liver Physiology. 295: G766-75. PMID 18703638 DOI: 10.1152/Ajpgi.90423.2008  0.31
2008 Wang W, Cronmiller C, Brautigan DL. Maternal phosphatase inhibitor-2 is required for proper chromosome segregation and mitotic synchrony during Drosophila embryogenesis. Genetics. 179: 1823-33. PMID 18689877 DOI: 10.1534/Genetics.108.091959  0.334
2008 Yoo SJ, Jimenez RH, Sanders JA, Boylan JM, Brautigan DL, Gruppuso PA. The alpha4-containing form of protein phosphatase 2A in liver and hepatic cells. Journal of Cellular Biochemistry. 105: 290-300. PMID 18543252 DOI: 10.1002/Jcb.21830  0.353
2008 Fuller BG, Lampson MA, Foley EA, Rosasco-Nitcher S, Le KV, Tobelmann P, Brautigan DL, Stukenberg PT, Kapoor TM. Midzone activation of aurora B in anaphase produces an intracellular phosphorylation gradient. Nature. 453: 1132-6. PMID 18463638 DOI: 10.1038/Nature06923  0.416
2008 Prickett TD, Ninomiya-Tsuji J, Broglie P, Muratore-Schroeder TL, Shabanowitz J, Hunt DF, Brautigan DL. TAB4 stimulates TAK1-TAB1 phosphorylation and binds polyubiquitin to direct signaling to NF-kappaB. The Journal of Biological Chemistry. 283: 19245-54. PMID 18456659 DOI: 10.1074/Jbc.M800943200  0.741
2008 Stefansson B, Ohama T, Daugherty AE, Brautigan DL. Protein phosphatase 6 regulatory subunits composed of ankyrin repeat domains. Biochemistry. 47: 1442-51. PMID 18186651 DOI: 10.1021/Bi7022877  0.775
2008 Li M, Stukenberg PT, Brautigan DL. Binding of phosphatase inhibitor-2 to prolyl isomerase Pin1 modifies specificity for mitotic phosphoproteins. Biochemistry. 47: 292-300. PMID 18062707 DOI: 10.1021/Bi701819K  0.496
2007 Eto M, Kitazawa T, Matsuzawa F, Aikawa Si, Kirkbride JA, Isozumi N, Nishimura Y, Brautigan DL, Ohki Sy. Phosphorylation-Induced Conformational Switching of CPI-17 Produces a Potent Myosin Phosphatase Inhibitor Structure. 15: 1591-1602. PMID 18073109 DOI: 10.1016/J.Str.2007.10.014  0.51
2007 Yang J, Roe SM, Prickett TD, Brautigan DL, Barford D. The structure of Tap42/alpha4 reveals a tetratricopeptide repeat-like fold and provides insights into PP2A regulation. Biochemistry. 46: 8807-15. PMID 17616149 DOI: 10.1021/Bi7007118  0.686
2007 Smith SC, Oxford G, Baras AS, Owens C, Havaleshko D, Brautigan DL, Safo MK, Theodorescu D. Expression of ral GTPases, their effectors, and activators in human bladder cancer. Clinical Cancer Research : An Official Journal of the American Association For Cancer Research. 13: 3803-13. PMID 17606711 DOI: 10.1158/1078-0432.Ccr-06-2419  0.318
2007 Stefansson B, Brautigan DL. Protein phosphatase PP6 N terminal domain restricts G1 to S phase progression in human cancer cells. Cell Cycle (Georgetown, Tex.). 6: 1386-92. PMID 17568194 DOI: 10.4161/Cc.6.11.4276  0.775
2007 Prickett TD, Brautigan DL. Cytokine activation of p38 mitogen-activated protein kinase and apoptosis is opposed by alpha-4 targeting of protein phosphatase 2A for site-specific dephosphorylation of MEK3. Molecular and Cellular Biology. 27: 4217-27. PMID 17438131 DOI: 10.1128/Mcb.00067-07  0.693
2007 Eto M, Kirkbride J, Elliott E, Lo SH, Brautigan DL. Association of the tensin N-terminal protein-tyrosine phosphatase domain with the alpha isoform of protein phosphatase-1 in focal adhesions. The Journal of Biological Chemistry. 282: 17806-15. PMID 17435217 DOI: 10.1074/Jbc.M700944200  0.458
2007 Yoo SJ, Boylan JM, Brautigan DL, Gruppuso PA. Subunit composition and developmental regulation of hepatic protein phosphatase 2A (PP2A). Archives of Biochemistry and Biophysics. 461: 186-93. PMID 17391644 DOI: 10.1016/J.Abb.2007.02.019  0.329
2007 Yang CS, Xin HW, Kelley JB, Spencer A, Brautigan DL, Paschal BM. Ligand binding to the androgen receptor induces conformational changes that regulate phosphatase interactions. Molecular and Cellular Biology. 27: 3390-404. PMID 17325038 DOI: 10.1128/Mcb.02411-06  0.411
2007 Li M, Satinover DL, Brautigan DL. Phosphorylation and functions of inhibitor-2 family of proteins. Biochemistry. 46: 2380-9. PMID 17286390 DOI: 10.1021/Bi602369M  0.546
2007 Mi J, Guo C, Brautigan DL, Larner JM. Protein phosphatase-1alpha regulates centrosome splitting through Nek2. Cancer Research. 67: 1082-9. PMID 17283141 DOI: 10.1158/0008-5472.Can-06-3071  0.448
2007 Eto M, Brautigan DL. Assay for three-way interaction of protein phosphatase-1 (Glc7) with regulatory subunits plus phosphatase inhibitor-2. Methods in Molecular Biology (Clifton, N.J.). 365: 197-208. PMID 17200563 DOI: 10.1385/1-59745-267-X:197  0.466
2007 Swain JE, Ding J, Brautigan DL, Villa-Moruzzi E, Smith GD. Proper chromatin condensation and maintenance of histone H3 phosphorylation during mouse oocyte meiosis requires protein phosphatase activity. Biology of Reproduction. 76: 628-38. PMID 17182892 DOI: 10.1095/Biolreprod.106.055798  0.379
2007 Guo C, Mi J, Brautigan DL, Larner JM. ATM regulates ionizing radiation-induced disruption of HDAC1:PP1:Rb complexes. Cellular Signalling. 19: 504-10. PMID 17008050 DOI: 10.1016/J.Cellsig.2006.08.001  0.455
2007 Wu Y, Wang H, Brautigan DL, Liu Z. Activation of glycogen synthase in myocardium induced by intermittent hypoxia is much lower in fasted than in fed rats. American Journal of Physiology. Endocrinology and Metabolism. 292: E469-75. PMID 17003235 DOI: 10.1152/Ajpendo.00486.2006  0.305
2007 Eto M, Kitazawa T, Matsuzawa F, Aikawa S, Kirkbride JA, Isozumi N, Nishimura Y, Brautigan DL, Ohki S. Structural insight into regulation of myosin phosphatase by CPI‐17. The Faseb Journal. 21. DOI: 10.1096/Fasebj.21.5.A520  0.518
2006 Kajino T, Ren H, Iemura S, Natsume T, Stefansson B, Brautigan DL, Matsumoto K, Ninomiya-Tsuji J. Protein phosphatase 6 down-regulates TAK1 kinase activation in the IL-1 signaling pathway. The Journal of Biological Chemistry. 281: 39891-6. PMID 17079228 DOI: 10.1074/Jbc.M608155200  0.796
2006 Satinover DL, Brautigan DL, Stukenberg PT. Aurora-A kinase and inhibitor-2 regulate the cyclin threshold for mitotic entry in Xenopus early embryonic cell cycles. Cell Cycle (Georgetown, Tex.). 5: 2268-74. PMID 16969136 DOI: 10.4161/Cc.5.19.3316  0.427
2006 Prickett TD, Brautigan DL. The alpha4 regulatory subunit exerts opposing allosteric effects on protein phosphatases PP6 and PP2A. The Journal of Biological Chemistry. 281: 30503-11. PMID 16895907 DOI: 10.1074/Jbc.M601054200  0.697
2006 Wang H, Brautigan DL. Peptide microarray analysis of substrate specificity of the transmembrane Ser/Thr kinase KPI-2 reveals reactivity with cystic fibrosis transmembrane conductance regulator and phosphorylase. Molecular & Cellular Proteomics : McP. 5: 2124-30. PMID 16887929 DOI: 10.1074/Mcp.M600188-Mcp200  0.467
2006 Stefansson B, Brautigan DL. Protein phosphatase 6 subunit with conserved Sit4-associated protein domain targets IkappaBepsilon. The Journal of Biological Chemistry. 281: 22624-34. PMID 16769727 DOI: 10.1074/Jbc.M601772200  0.78
2006 Li M, Stefansson B, Wang W, Schaefer EM, Brautigan DL. Phosphorylation of the Pro-X-Thr-Pro site in phosphatase inhibitor-2 by cyclin-dependent protein kinase during M-phase of the cell cycle. Cellular Signalling. 18: 1318-26. PMID 16377132 DOI: 10.1016/J.Cellsig.2005.10.020  0.804
2006 Brautigan D. Protein phosphatase inhibitor-2 Afcs-Nature Molecule Pages. DOI: 10.1038/Mp.A001939.01  0.463
2005 Molhoek KR, Brautigan DL, Slingluff CL. Synergistic inhibition of human melanoma proliferation by combination treatment with B-Raf inhibitor BAY43-9006 and mTOR inhibitor Rapamycin. Journal of Translational Medicine. 3: 39. PMID 16255777 DOI: 10.1186/1479-5876-3-39  0.36
2005 Eto M, Kirkbride JA, Brautigan DL. Assembly of MYPT1 with protein phosphatase-1 in fibroblasts redirects localization and reorganizes the actin cytoskeleton. Cell Motility and the Cytoskeleton. 62: 100-9. PMID 16106448 DOI: 10.1002/Cm.20088  0.443
2005 Brautigan DL, Brown M, Grindrod S, Chinigo G, Kruszewski A, Lukasik SM, Bushweller JH, Horal M, Keller S, Tamura S, Heimark DB, Price J, Larner AN, Larner J. Allosteric activation of protein phosphatase 2C by D-chiro-inositol-galactosamine, a putative mediator mimetic of insulin action. Biochemistry. 44: 11067-73. PMID 16101290 DOI: 10.1021/Bi0508845  0.366
2005 Wang H, Kruszewski A, Brautigan DL. Cellular chromium enhances activation of insulin receptor kinase. Biochemistry. 44: 8167-75. PMID 15924436 DOI: 10.1021/Bi0473152  0.38
2005 Yang CS, Vitto MJ, Busby SA, Garcia BA, Kesler CT, Gioeli D, Shabanowitz J, Hunt DF, Rundell K, Brautigan DL, Paschal BM. Simian virus 40 small t antigen mediates conformation-dependent transfer of protein phosphatase 2A onto the androgen receptor. Molecular and Cellular Biology. 25: 1298-308. PMID 15684382 DOI: 10.1128/Mcb.25.4.1298-1308.2005  0.398
2005 Brautigan DL, Brown MF, Grindrod S, Chinigo G, Kruszewski A, Lukasik SM, Bushweller JH, Horal M, Keller S, Tamura S, Heimark DB, Price J, Larner AN, Larner J. Erratum: Allosteric activation of protein phosphatase 2C by D-chiro-inositol-galactosamine, a putative mediator mimetic of insulin action (Biochemistry (August 23, 2005) 44, 33 (11067-11073)) Biochemistry. 44. DOI: 10.1021/Bi0580308  0.345
2004 Tountas NA, Brautigan DL. Migration and retraction of endothelial and epithelial cells require PHI-1, a specific protein-phosphatase-1 inhibitor protein. Journal of Cell Science. 117: 5905-12. PMID 15522888 DOI: 10.1242/Jcs.01506  0.742
2004 Prickett TD, Brautigan DL. Overlapping binding sites in protein phosphatase 2A for association with regulatory A and alpha-4 (mTap42) subunits. The Journal of Biological Chemistry. 279: 38912-20. PMID 15252037 DOI: 10.1074/Jbc.M401444200  0.694
2004 Eto M, Kitazawa T, Brautigan DL. Phosphoprotein inhibitor CPI-17 specificity depends on allosteric regulation of protein phosphatase-1 by regulatory subunits. Proceedings of the National Academy of Sciences of the United States of America. 101: 8888-93. PMID 15184667 DOI: 10.1073/Pnas.0307812101  0.516
2004 Satinover DL, Leach CA, Stukenberg PT, Brautigan DL. Activation of Aurora-A kinase by protein phosphatase inhibitor-2, a bifunctional signaling protein. Proceedings of the National Academy of Sciences of the United States of America. 101: 8625-30. PMID 15173575 DOI: 10.1073/Pnas.0402966101  0.763
2004 Tountas NA, Mandell JW, Everett AD, Brautigan DL. Juxtamembrane localization of the protein phosphatase-1 inhibitor protein PHI-1 in smooth muscle cells. Histochemistry and Cell Biology. 121: 343-50. PMID 15083373 DOI: 10.1007/S00418-004-0642-8  0.75
2004 Ohki Sy, Eto M, Takada R, Shimizu M, Brautigan DL, Kainosho M. Phosphorylation-induced conformational change responsible for the function of a myosin phosphatase inhibitor, CPI-17 Science and Technology of Advanced Materials. 5: 383-386. DOI: 10.1016/J.Stam.2004.01.008  0.437
2003 Eto M, Leach C, Tountas NA, Brautigan DL. Phosphoprotein inhibitors of protein phosphatase-1. Methods in Enzymology. 366: 243-60. PMID 14674253 DOI: 10.1016/S0076-6879(03)66019-2  0.816
2003 Erdodi F, Kiss E, Walsh MP, Stefansson B, Deng JT, Eto M, Brautigan DL, Hartshorne DJ. Phosphorylation of protein phosphatase type-1 inhibitory proteins by integrin-linked kinase and cyclic nucleotide-dependent protein kinases. Biochemical and Biophysical Research Communications. 306: 382-7. PMID 12804574 DOI: 10.1016/S0006-291X(03)00976-8  0.804
2003 Murthy KS, Zhou H, Grider JR, Brautigan DL, Eto M, Makhlouf GM. Differential signalling by muscarinic receptors in smooth muscle: m2-mediated inactivation of myosin light chain kinase via Gi3, Cdc42/Rac1 and p21-activated kinase 1 pathway, and m3-mediated MLC20 (20 kDa regulatory light chain of myosin II) phosphorylation via Rho-associated kinase/myosin phosphatase targeting subunit 1 and protein kinase C/CPI-17 pathway. The Biochemical Journal. 374: 145-55. PMID 12733988 DOI: 10.1042/Bj20021274  0.513
2003 Leach C, Shenolikar S, Brautigan DL. Phosphorylation of phosphatase inhibitor-2 at centrosomes during mitosis. The Journal of Biological Chemistry. 278: 26015-20. PMID 12697755 DOI: 10.1074/Jbc.M300782200  0.739
2003 Ohki Sy, Eto M, Shimizu M, Takada R, Brautigan DL, Kainosho M. Distinctive solution conformation of phosphatase inhibitor CPI-17 substituted with aspartate at the phosphorylation-site threonine residue. Journal of Molecular Biology. 326: 1539-47. PMID 12595264 DOI: 10.1016/S0022-2836(03)00048-2  0.424
2003 Eto M, Leach C, Tountas NA, Brautigan DL. [19] Phosphoprotein Inhibitors of Protein Phosphatase-1 Methods in Enzymology. 366: 243-260.  0.756
2002 Eto M, Bock R, Brautigan DL, Linden DJ. Cerebellar long-term synaptic depression requires PKC-mediated activation of CPI-17, a myosin/moesin phosphatase inhibitor. Neuron. 36: 1145-58. PMID 12495628 DOI: 10.1016/S0896-6273(02)01107-8  0.402
2002 Wang H, Brautigan DL. A novel transmembrane Ser/Thr kinase complexes with protein phosphatase-1 and inhibitor-2. The Journal of Biological Chemistry. 277: 49605-12. PMID 12393858 DOI: 10.1074/Jbc.M209335200  0.533
2002 Terry-Lorenzo RT, Elliot E, Weiser DC, Prickett TD, Brautigan DL, Shenolikar S. Neurabins recruit protein phosphatase-1 and inhibitor-2 to the actin cytoskeleton. The Journal of Biological Chemistry. 277: 46535-43. PMID 12270929 DOI: 10.1074/Jbc.M206960200  0.71
2002 Leach C, Eto M, Brautigan DL. Domains of type 1 protein phosphatase inhibitor-2 required for nuclear and cytoplasmic localization in response to cell-cell contact. Journal of Cell Science. 115: 3739-45. PMID 12235284 DOI: 10.1242/Jcs.00052  0.687
2002 Eto M, Elliott E, Prickett TD, Brautigan DL. Inhibitor-2 regulates protein phosphatase-1 complexed with NimA-related kinase to induce centrosome separation. The Journal of Biological Chemistry. 277: 44013-20. PMID 12221103 DOI: 10.1074/Jbc.M208035200  0.758
2002 Everett AD, Brautigan DL. Developmental expression of alpha4 protein phosphatase regulatory subunit in tissues affected by Opitz syndrome. Developmental Dynamics : An Official Publication of the American Association of Anatomists. 224: 461-4. PMID 12203739 DOI: 10.1002/Dvdy.10125  0.31
2002 Guo CY, Brautigan DL, Larner JM. Ionizing radiation activates nuclear protein phosphatase-1 by ATM-dependent dephosphorylation. The Journal of Biological Chemistry. 277: 41756-61. PMID 12202491 DOI: 10.1074/Jbc.M207519200  0.515
2002 Deng JT, Sutherland C, Brautigan DL, Eto M, Walsh MP. Phosphorylation of the myosin phosphatase inhibitors, CPI-17 and PHI-1, by integrin-linked kinase. The Biochemical Journal. 367: 517-24. PMID 12144526 DOI: 10.1042/Bj20020522  0.51
2002 Zhou B, Wang ZX, Zhao Y, Brautigan DL, Zhang ZY. The specificity of extracellular signal-regulated kinase 2 dephosphorylation by protein phosphatases. The Journal of Biological Chemistry. 277: 31818-25. PMID 12082107 DOI: 10.1074/Jbc.M203969200  0.54
2002 Oliver CJ, Terry-Lorenzo RT, Elliott E, Bloomer WA, Li S, Brautigan DL, Colbran RJ, Shenolikar S. Targeting protein phosphatase 1 (PP1) to the actin cytoskeleton: the neurabin I/PP1 complex regulates cell morphology. Molecular and Cellular Biology. 22: 4690-701. PMID 12052877 DOI: 10.1128/Mcb.22.13.4690-4701.2002  0.489
2002 Everett AD, Kamibayashi C, Brautigan DL. Transgenic expression of protein phosphatase 2A regulatory subunit B56gamma disrupts distal lung differentiation. American Journal of Physiology. Lung Cellular and Molecular Physiology. 282: L1266-71. PMID 12003782 DOI: 10.1152/Ajplung.00262.2001  0.31
2002 Ohki S, Eto M, Kariya E, Hayano T, Hayashi Y, Yazawa M, Brautigan D, Kainosho M. Solution NMR structure of the myosin phosphatase inhibitor protein CPI-17 shows phosphorylation-induced conformational changes responsible for activation. Journal of Molecular Biology. 314: 839-49. PMID 11734001 DOI: 10.1006/Jmbi.2001.5200  0.478
2002 Guo CY, Brautigan DL, Larner JM. ATM-dependent dissociation of B55 regulatory subunit from nuclear PP2A in response to ionizing radiation. The Journal of Biological Chemistry. 277: 4839-44. PMID 11723136 DOI: 10.1074/Jbc.M110092200  0.432
2002 Broustas CG, Grammatikakis N, Eto M, Dent P, Brautigan DL, Kasid U. Phosphorylation of the myosin-binding subunit of myosin phosphatase by Raf-1 and inhibition of phosphatase activity. The Journal of Biological Chemistry. 277: 3053-9. PMID 11719507 DOI: 10.1074/Jbc.M106343200  0.545
2001 Woodsome TP, Eto M, Everett A, Brautigan DL, Kitazawa T. Expression of CPI-17 and myosin phosphatase correlates with Ca(2+) sensitivity of protein kinase C-induced contraction in rabbit smooth muscle. The Journal of Physiology. 535: 553-64. PMID 11533144 DOI: 10.1111/J.1469-7793.2001.T01-1-00553.X  0.331
2001 Hayashi Y, Senba S, Yazawa M, Brautigan DL, Eto M. Defining the structural determinants and a potential mechanism for inhibition of myosin phosphatase by the protein kinase C-potentiated inhibitor protein of 17 kDa. The Journal of Biological Chemistry. 276: 39858-63. PMID 11517233 DOI: 10.1074/Jbc.M107302200  0.503
2001 Etter EF, Eto M, Wardle RL, Brautigan DL, Murphy RA. Activation of myosin light chain phosphatase in intact arterial smooth muscle during nitric oxide-induced relaxation. The Journal of Biological Chemistry. 276: 34681-5. PMID 11461918 DOI: 10.1074/Jbc.M104737200  0.37
2001 Everett AD, Stoops TD, Nairn AC, Brautigan D. Angiotensin II regulates phosphorylation of translation elongation factor-2 in cardiac myocytes. American Journal of Physiology. Heart and Circulatory Physiology. 281: H161-7. PMID 11406481 DOI: 10.1152/Ajpheart.2001.281.1.H161  0.442
2001 Eto M, Kitazawa T, Yazawa M, Mukai H, Ono Y, Brautigan DL. Histamine-induced vasoconstriction involves phosphorylation of a specific inhibitor protein for myosin phosphatase by protein kinase C alpha and delta isoforms. The Journal of Biological Chemistry. 276: 29072-8. PMID 11397799 DOI: 10.1074/Jbc.M103206200  0.531
2001 Liu J, Prickett TD, Elliott E, Meroni G, Brautigan DL. Phosphorylation and microtubule association of the Opitz syndrome protein mid-1 is regulated by protein phosphatase 2A via binding to the regulatory subunit alpha 4. Proceedings of the National Academy of Sciences of the United States of America. 98: 6650-5. PMID 11371618 DOI: 10.1073/Pnas.111154698  0.721
2001 MacDonald JA, Eto M, Borman MA, Brautigan DL, Haystead TA. Dual Ser and Thr phosphorylation of CPI-17, an inhibitor of myosin phosphatase, by MYPT-associated kinase. Febs Letters. 493: 91-4. PMID 11287002 DOI: 10.1016/S0014-5793(01)02277-3  0.472
2000 Shenolikar S, Brautigan DL. Meeting report: targeting protein phosphatases-medicines for the new millenium. Science's Stke : Signal Transduction Knowledge Environment. 2000: pe1. PMID 11752618 DOI: 10.1126/Stke.2000.57.Pe1  0.392
2000 Eto M, Wong L, Yazawa M, Brautigan DL. Inhibition of myosin/moesin phosphatase by expression of the phosphoinhibitor protein CPI-17 alters microfilament organization and retards cell spreading. Cell Motility and the Cytoskeleton. 46: 222-34. PMID 10913968 DOI: 10.1002/1097-0169(200007)46:3<222::Aid-Cm6>3.0.Co;2-B  0.496
2000 Liu J, Brautigan DL. Glycogen synthase association with the striated muscle glycogen-targeting subunit of protein phosphatase-1. Synthase activation involves scaffolding regulated by beta-adrenergic signaling. The Journal of Biological Chemistry. 275: 26074-81. PMID 10856301 DOI: 10.1074/Jbc.M003843200  0.441
2000 Liu J, Brautigan DL. Insulin-stimulated phosphorylation of the protein phosphatase-1 striated muscle glycogen-targeting subunit and activation of glycogen synthase. The Journal of Biological Chemistry. 275: 15940-7. PMID 10748124 DOI: 10.1074/Jbc.M909303199  0.388
2000 Kitazawa T, Eto M, Woodsome TP, Brautigan DL. Agonists trigger G protein-mediated activation of the CPI-17 inhibitor phosphoprotein of myosin light chain phosphatase to enhance vascular smooth muscle contractility. The Journal of Biological Chemistry. 275: 9897-900. PMID 10744661 DOI: 10.1074/Jbc.275.14.9897  0.455
2000 Liu J, Wu J, Oliver C, Shenolikar S, Brautigan DL. Mutations of the serine phosphorylated in the protein phosphatase-1-binding motif in the skeletal muscle glycogen-targeting subunit. The Biochemical Journal. 346: 77-82. PMID 10657242 DOI: 10.1042/0264-6021:3460077  0.413
1999 Eto M, Karginov A, Brautigan DL. A novel phosphoprotein inhibitor of protein type-1 phosphatase holoenzymes. Biochemistry. 38: 16952-7. PMID 10606530 DOI: 10.1021/Bi992030O  0.58
1999 Chung H, Nairn AC, Murata K, Brautigan DL. Mutation of Tyr307 and Leu309 in the protein phosphatase 2A catalytic subunit favors association with the alpha 4 subunit which promotes dephosphorylation of elongation factor-2. Biochemistry. 38: 10371-6. PMID 10441131 DOI: 10.1021/Bi990902G  0.455
1999 Chung H, Brautigan DL. Protein phosphatase 2A suppresses MAP kinase signalling and ectopic protein expression. Cellular Signalling. 11: 575-80. PMID 10433518 DOI: 10.1016/S0898-6568(99)00033-9  0.462
1999 Guo CY, Wang Y, Brautigan DL, Larner JM. Histone H1 dephosphorylation is mediated through a radiation-induced signal transduction pathway dependent on ATM. The Journal of Biological Chemistry. 274: 18715-20. PMID 10373485 DOI: 10.1074/Jbc.274.26.18715  0.359
1998 Wu J, Liu J, Thompson I, Oliver CJ, Shenolikar S, Brautigan DL. A conserved domain for glycogen binding in protein phosphatase-1 targeting subunits. Febs Letters. 439: 185-91. PMID 9849903 DOI: 10.1016/S0014-5793(98)01371-4  0.418
1998 Liao H, Li Y, Brautigan DL, Gundersen GG. Protein phosphatase 1 is targeted to microtubules by the microtubule-associated protein Tau. The Journal of Biological Chemistry. 273: 21901-8. PMID 9705329 DOI: 10.1074/Jbc.273.34.21901  0.48
1998 Brautigan DL, Kakinoki Y, Fernandez A, Lamb NJC. Cell cycle nuclear localization of phosphatase inhibitor-2 Faseb Journal. 12.  0.337
1997 Kakinoki Y, Somers J, Brautigan DL. Multisite phosphorylation and the nuclear localization of phosphatase inhibitor 2-green fluorescent protein fusion protein during S phase of the cell growth cycle Journal of Biological Chemistry. 272: 32308-32314. PMID 9405437 DOI: 10.1074/Jbc.272.51.32308  0.473
1997 Murata K, Wu J, Brautigan DL. B cell receptor-associated protein α4 displays rapamycin-sensitive binding directly to the catalytic subunit of protein phosphatase 2A Proceedings of the National Academy of Sciences of the United States of America. 94: 10624-10629. PMID 9380685 DOI: 10.1073/Pnas.94.20.10624  0.472
1997 Murata K, Hirano K, Villa-Moruzzi E, Hartshorne DJ, Brautigan DL. Differential localization of myosin and myosin phosphatase subunits in smooth muscle cells and migrating fibroblasts Molecular Biology of the Cell. 8: 663-673. PMID 9247646 DOI: 10.1091/Mbc.8.4.663  0.375
1996 Wu J, Kleiner U, Brautigan DL. Protein phosphatase type-I and glycogen bind to a domain in the skeletal muscle regulatory subunit containing conserved hydrophobic sequence motifs' Biochemistry. 35: 13858-13864. PMID 8901529 DOI: 10.1021/Bi961669E  0.454
1996 Reardon DB, Wood SL, Brautigan DL, Bell GI, Dent P, Sturgill TW. Activation of a protein tyrosine phosphatase and inactivation of Raf-1 by somatostatin. The Biochemical Journal. 314: 401-4. PMID 8670047 DOI: 10.1042/Bj3140401  0.47
1996 Dent P, Reardon DB, Wood SL, Lindorfer MA, Graber SG, Garrison JC, Brautigan DL, Sturgill TW. Inactivation of raf-1 by a protein-tyrosine phosphatase stimulated by GTP and reconstituted by Galphai/o subunits. The Journal of Biological Chemistry. 271: 3119-23. PMID 8621710 DOI: 10.1074/Jbc.271.6.3119  0.377
1995 Brautigan DL. Flicking the switches: Phosphorylation of serine/threonine protein phosphatases Seminars in Cancer Biology. 6: 211-217. PMID 8541516 DOI: 10.1006/Scbi.1995.0028  0.533
1995 Williams JP, Jo H, Hunnicutt RE, Brautigan DL, McDonald JM. Tyrosine phosphorylation of phosphatase inhibitor 2. Journal of Cellular Biochemistry. 57: 415-22. PMID 7768977 DOI: 10.1002/Jcb.240570307  0.504
1994 Belandia B, Brautigan D, Martín-Pérez J. Attenuation of ribosomal protein S6 phosphatase activity in chicken embryo fibroblasts transformed by Rous sarcoma virus. Molecular and Cellular Biology. 14: 200-6. PMID 8264587 DOI: 10.1128/Mcb.14.1.200  0.366
1994 Toivola DM, Eriksson JE, Brautigan DL. Identification of protein phosphatase 2A as the primary target for microcystin-LR in rat liver homogenates Febs Letters. 344: 175-180. PMID 8187879 DOI: 10.1016/0014-5793(94)00382-3  0.378
1994 Wang LY, Orser BA, Brautigan DL, MacDonald JF. Regulation of NMDA receptors in cultured hippocampal neurons by protein phosphatases 1 and 2A. Nature. 369: 230-2. PMID 8183343 DOI: 10.1038/369230A0  0.358
1994 Brautigan DL. Protein phosphatases Recent Progress in Hormone Research. 49. PMID 8146424  0.321
1994 Martin BI, Shriner CL, Brautigan DL. Concurrent purification of type-1 and type-2A protein phosphatase catalytic subunits Protein Expression and Purification. 5: 211-217. PMID 7950363 DOI: 10.1006/Prep.1994.1033  0.425
1994 Chen J, Parsons S, Brautigan DL. Tyrosine phosphorylation of protein phosphatase 2A in response to growth stimulation and v-src transformation of fibroblasts Journal of Biological Chemistry. 269: 7957-7962. PMID 7510677  0.383
1993 Brautigan DL, Pinault FM. Serine phosphorylation of protein tyrosine phosphatase (PTP1B) in HeLa cells in response to analogues of cAMP or diacylglycerol plus okadaic acid Molecular and Cellular Biochemistry. 127: 121-129. PMID 7935344 DOI: 10.1007/Bf01076763  0.553
1992 Brautigan DL. Great expectations: protein tyrosine phosphatases in cell regulation Bba - Reviews On Cancer. 1114: 63-77. PMID 1390871 DOI: 10.1016/0304-419X(92)90007-L  0.526
1992 Gordon SE, Brautigan DL, Zimmerman AL. Protein phosphatases modulate the apparent agonist affinity of the light-regulated ion channel in retinal rods. Neuron. 9: 739-48. PMID 1382474 DOI: 10.1016/0896-6273(92)90036-D  0.37
1992 Eriksson JE, Brautigan DL, Vallee R, Olmsted J, Fujiki H, Goldman RD. Cytoskeletal integrity in interphase cells requires protein phosphatase activity. Proceedings of the National Academy of Sciences of the United States of America. 89: 11093-7. PMID 1332069 DOI: 10.1073/Pnas.89.22.11093  0.511
1992 Suganuma M, Fujiki H, Okabe S, Nishiwaki S, Brautigan D, Ingebritsen TS, Rosner MR. Structurally different members of the okadaic acid class selectively inhibit protein serine/threonine but not tyrosine phosphatase activity. Toxicon : Official Journal of the International Society On Toxinology. 30: 873-8. PMID 1326138 DOI: 10.1016/0041-0101(92)90385-I  0.414
1992 Chen J, Martin BL, Brautigan DL. Regulation of protein serine-threonine phosphatase type-2A by tyrosine phosphorylation Science. 257: 1261-1264. PMID 1325671 DOI: 10.1126/Science.1325671  0.52
1992 Kyriakis JM, App H, Zhang XF, Banerjee P, Brautigan DL, Rapp UR, Avruch J. Raf-1 activates MAP kinase-kinase Nature. 358: 417-421. PMID 1322500 DOI: 10.1038/358417A0  0.448
1992 Finn AL, Gaido ML, Dillard M, Brautigan DL. Regulation of an epithelial chloride channel by direct phosphorylation and dephosphorylation American Journal of Physiology - Cell Physiology. 263. PMID 1322039 DOI: 10.1152/Ajpcell.1992.263.1.C172  0.464
1992 Boylan JM, Brautigan DL, Madden J, Raven T, Ellis L, Gruppuso PA. Differential regulation of multiple hepatic protein tyrosine phosphatases in alloxan diabetic rats. The Journal of Clinical Investigation. 90: 174-9. PMID 1321840 DOI: 10.1172/Jci115833  0.385
1992 DeRemer MF, Saeli RJ, Brautigan DL, Edelman AM. Ca(2+)-calmodulin-dependent protein kinases Ia and Ib from rat brain. II. Enzymatic characteristics and regulation of activities by phosphorylation and dephosphorylation. The Journal of Biological Chemistry. 267: 13466-71. PMID 1320022  0.398
1992 Fernandez A, Brautigan DL, Lamb NJC. Protein phosphatase type 1 in mammalian cell mitosis: Chromosomal localization and involvement in mitotic exit Journal of Cell Biology. 116: 1421-1430. PMID 1311712 DOI: 10.1083/Jcb.116.6.1421  0.37
1991 Washburn T, Hocutt A, Brautigan DL, Korach KS. Uterine estrogen receptor in vivo: Phosphorylation of nuclear specific forms on serine residues Molecular Endocrinology. 5: 235-242. PMID 2038345 DOI: 10.1210/Mend-5-2-235  0.32
1991 Chung SK, Reinhart PH, Martin BL, Brautigan D, Levitan IB. Protein kinase activity closely associated with a reconstituted calcium-activated potassium channel. Science (New York, N.Y.). 253: 560-2. PMID 1857986 DOI: 10.1126/Science.1857986  0.439
1991 Gruppuso PA, Boylan JM, Smiley BL, Fallon RJ, Brautigan DL. Hepatic protein tyrosine phosphatases in the rat. The Biochemical Journal. 274: 361-7. PMID 1848753 DOI: 10.1042/Bj2740361  0.386
1991 DeFranco DB, Qi M, Borror KC, Garabedian MJ, Brautigan DL. Protein phosphatase types 1 and/or 2A regulate nucleocytoplasmic shuttling of glucocorticoid receptors Molecular Endocrinology. 5: 1215-1228. PMID 1663212 DOI: 10.1210/Mend-5-9-1215  0.382
1991 Nyomba BL, Brautigan DL, Schlender KK, Wang W, Bogardus C, Mott DM. Deficiency in phosphorylase phosphatase activity despite elevated protein phosphatase type-1 catalytic subunit in skeletal muscle from insulin-resistant subjects Journal of Clinical Investigation. 88: 1540-1545. PMID 1658044 DOI: 10.1172/Jci115464  0.398
1991 Brautigan DL, Pinault FM. Activation of membrane protein-tyrosine phosphatase involving cAMP- And Ca2+/phospholipid-dependent protein kinases Proceedings of the National Academy of Sciences of the United States of America. 88: 6696-6700. PMID 1650478 DOI: 10.1073/Pnas.88.15.6696  0.532
1991 Martin BL, Shriner CL, Brautigan DL. Modulation of type-1 protein phosphatase by synthetic peptides corresponding to the carboxyl terminus Febs Letters. 285: 6-10. PMID 1648514 DOI: 10.1016/0014-5793(91)80712-C  0.33
1991 Reinhart PH, Chung S, Martin BL, Brautigan DL, Levitan IB. Modulation of calcium-activated potassium channels from rat brain by protein kinase A and phosphatase 2A. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 11: 1627-35. PMID 1646298 DOI: 10.1523/Jneurosci.11-06-01627.1991  0.339
1991 Kyriakist JM, Brautigan DL, Ingebritsen TS, Avruch J. Pp54 microtubule-associated protein-2 kinase requires both tyrosine and serine/threonine phosphorylation for activity Journal of Biological Chemistry. 266: 10043-10046. PMID 1645334  0.4
1990 Brautigan DL, Sunwoo J, Labbé JC, Fernandez A, Lamb NJ. Cell cycle oscillation of phosphatase inhibitor-2 in rat fibroblasts coincident with p34cdc2 restriction. Nature. 344: 74-8. PMID 2406614 DOI: 10.1038/344074A0  0.47
1990 Fernandez A, Brautigan DL, Mumby M, Lamb NJC. Protein phosphatase type-1, not type-2A, modulates actin microfilament integrity and myosin light chain phosphorylation in living nonmuscle cells Journal of Cell Biology. 111: 103-112. PMID 2164027 DOI: 10.1083/Jcb.111.1.103  0.421
1990 Gruppuso PA, Boylan JM, Posner BI, Faure R, Brautigan DL. Hepatic protein phosphotyrosine phosphatase. Dephosphorylation of insulin and epidermal growth factor receptors in normal and alloxan diabetic rats. The Journal of Clinical Investigation. 85: 1754-60. PMID 2161429 DOI: 10.1172/Jci114632  0.324
1990 Pallas DC, Shahrik LK, Martin BL, Jaspers S, Miller TB, Brautigan DL, Roberts TM. Polyoma small and middle T antigens and SV40 small t antigen form stable complexes with protein phosphatase 2A Cell. 60: 167-176. PMID 2153055 DOI: 10.1016/0092-8674(90)90726-U  0.355
1989 Picard A, Capony JP, Brautigan DL, Doree M. Involvement of protein phosphatases 1 and 2A in the control of M phase-promoting factor activity in starfish Journal of Cell Biology. 109: 3347-3354. PMID 2574724 DOI: 10.1083/Jcb.109.6.3347  0.47
1989 Brautigan DL, Shriner CL. Protein phosphatase type 1 catalytic subunit forms nondissociable dimers Archives of Biochemistry and Biophysics. 275: 44-52. PMID 2554811 DOI: 10.1016/0003-9861(89)90348-2  0.407
1989 Ishihara H, Martin BL, Brautigan DL, Karaki H, Ozaki H, Kato Y, Fusetani N, Watabe S, Hashimoto K, Uemura D. Calyculin A and okadaic acid: inhibitors of protein phosphatase activity. Biochemical and Biophysical Research Communications. 159: 871-7. PMID 2539153 DOI: 10.1016/0006-291X(89)92189-X  0.355
1989 Gruppuso PA, Brautigan DL. Induction of hepatic glycogenesis in the fetal rat American Journal of Physiology - Endocrinology and Metabolism. 256: 19/1. PMID 2492154 DOI: 10.1152/Ajpendo.1989.256.1.E49  0.32
1988 Roome J, O'Hare T, Pilch PF, Brautigan DL. Protein phosphotyrosine phosphatase purified from the particulate fraction of human placenta dephosphorylates insulin and growth-factor receptors Biochemical Journal. 256: 493-500. PMID 2851993 DOI: 10.1042/Bj2560493  0.419
1988 Brautigan DL, Shriner CL. Methods to distinguish various types of protein phosphatase activity Methods in Enzymology. 159: 339-346. PMID 2842599 DOI: 10.1016/0076-6879(88)59034-1  0.394
1988 Arino J, Woon CW, Brautigan DL, Miller TB, Johnson GL. Human liver phosphatase 2A: cDNA and amino acid sequence of two catalytic subunit isotypes Proceedings of the National Academy of Sciences of the United States of America. 85: 4252-4256. PMID 2837763 DOI: 10.1073/Pnas.85.12.4252  0.324
1988 Brautigan DL, Kuplic JD. Proposal for a pathway to mediate the metabolic effects of insulin International Journal of Biochemistry. 20: 349-356. PMID 2835273 DOI: 10.1016/0020-711X(88)90200-5  0.401
1988 Brautigan DL. Molecular defects in ion channel regulation in cystic fibrosis predicted from analysis of protein phosphorylation/dephosphorylation International Journal of Biochemistry. 20: 745-752. PMID 2458979 DOI: 10.1016/0020-711X(88)90059-6  0.479
1987 Johnson GL, Brautigan DL, Shriner C, Jaspers S, Arino J, Mole JE, Miller TB, Mumby MC. Sequence homologies between type 1 and type 2A protein phosphatases. Molecular Endocrinology (Baltimore, Md.). 1: 745-8. PMID 2856400 DOI: 10.1210/Mend-1-10-745  0.343
1987 Gruppuso PA, Shriner CL, Brautigan DL. Latent forms of type-1 protein phosphatase in rabbit skeletal muscle Biochemical and Biophysical Research Communications. 148: 1174-1181. PMID 2825677 DOI: 10.1016/S0006-291X(87)80256-5  0.335
1987 Rotenberg SA, Brautigan DL. Membrane protein phosphotyrosine phosphatase in rabbit kidney. Proteolysis activates the enzyme and generates soluble catalytic fragments Biochemical Journal. 243: 747-754. PMID 2821989 DOI: 10.1042/Bj2430747  0.39
1987 Gruppuso PA, Brautigan DL, Schwartz R. INTRINSIC REGULATION OF GLYCOGEN PARTICLES: LIVER v. SKELETAL MUSCLE Pediatric Research. 21: 342A-342A. DOI: 10.1203/00006450-198704010-01047  0.414
1986 Brautigan DL, Gruppuso PA, Mumby M. Protein phosphatase type-1 and type-2 catalytic subunits both bind inhibitor-2 and monoclonal immunoglobulins Journal of Biological Chemistry. 261: 14924-14928. PMID 3021755  0.321
1986 Sparks JW, Brautigan DL. Molecular basis for substrate specificity of protein kinases and phosphatases International Journal of Biochemistry. 18: 497-504. PMID 3011539 DOI: 10.1016/0020-711X(86)90159-X  0.509
1985 Brautigan DL, Randazzo P, Shriner C, Fain JN. Phosphorylation of chloroform soluble compounds in plasma membranes of human epidermoid carcinoma A431 cells Lipids. 20: 492-495. PMID 2993780 DOI: 10.1007/Bf02534242  0.409
1985 Sparks JW, Brautigan DL. Specificity of protein phosphotyrosine phosphatases. Comparison with mammalian alkaline phosphatase using polypeptide substrates Journal of Biological Chemistry. 260: 2042-2045. PMID 2982803  0.398
1985 Gruppuso P, Shriner CL, Brautigan DL. Reconstitution of the phosphorylase phosphatase holoenzyme Federation Proceedings. 44.  0.339
1983 Ballou LM, Brautigan DL, Fischer EH. Subunit structure and activation of inactive phosphorylase phosphatase. Biochemistry. 22: 3393-9. PMID 6311247 DOI: 10.1021/Bi00283A014  0.336
1982 Brautigan DL, Khatra BS, Soderling TR, Fischer EH. Dephosphorylation of skeletal muscle phosphorylase, glycogen synthase, and phosphorylase kinase beta-subunit by a Mn2+-activated protein phosphatase. Archives of Biochemistry and Biophysics. 219: 228-35. PMID 6295283 DOI: 10.1016/0003-9861(82)90153-9  0.442
1982 Brautigan DL, Ballou LM, Fischer EH. Activation of skeletal muscle phosphorylase phosphatase. Effects of proteolysis and divalent cations Biochemistry. 21: 1977-1982. PMID 6284210 DOI: 10.1021/Bi00538A001  0.324
1981 Gallis B, Bornstein P, Brautigan DL. Tyrosylprotein kinase and phosphatase activities in membrane vesicles from normal and Rous sarcoma virus-transformed rat cells Proceedings of the National Academy of Sciences of the United States of America. 78: 6689-6693. PMID 6273884  0.331
1981 Brautigan DL, Bornstein P, Gallis B. Phosphotyrosyl-protein phosphatase. Specific inhibition by Zn Journal of Biological Chemistry. 256: 6519-6522. PMID 6165721  0.367
1980 Brautigan DL, Picton C, Fischer EH. Phosphorylase phosphatase complex from skeletal muscle. Activation of one of two catalytic subunits by manganese ions Biochemistry. 19: 5787-5794. PMID 6257290 DOI: 10.1021/Bi00566A019  0.379
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