| Year |
Citation |
Score |
| 2023 |
Li C, Liu Z, Anderson J, Liu Z, Tang L, Li Y, Peng N, Chen J, Liu X, Fu L, Townes TM, Rowe SM, Bedwell DM, Guimbellot J, Zhao R. Prime editing-mediated correction of the CFTR W1282X mutation in iPSCs and derived airway epithelial cells. Plos One. 18: e0295009. PMID 38019847 DOI: 10.1371/journal.pone.0295009 |
0.301 |
|
| 2023 |
Staedtke V, Anstett K, Bedwell D, Giovannini M, Keeling K, Kesterson R, Kim Y, Korf B, Leier A, McManus ML, Sarnoff H, Vitte J, Walker JA, Plotkin SR, Wallis D. Gene-targeted therapy for neurofibromatosis and schwannomatosis: The path to clinical trials. Clinical Trials (London, England). 17407745231207970. PMID 37937606 DOI: 10.1177/17407745231207970 |
0.644 |
|
| 2023 |
Chen J, Thrasher K, Fu L, Wang W, Aghamohammadzadeh S, Wen H, Tang L, Keeling KM, Falk Libby E, Bedwell DM, Rowe SM. The synthetic aminoglycoside ELX-02 induces readthrough of G550X-CFTR producing super-functional protein that can be further enhanced by CFTR modulators. American Journal of Physiology. Lung Cellular and Molecular Physiology. PMID 37014818 DOI: 10.1152/ajplung.00038.2023 |
0.694 |
|
| 2023 |
Siddiqui A, Dundar H, Sharma J, Kaczmarczyk A, Echols J, Dai Y, Sun CR, Du M, Liu Z, Zhao R, Wood T, Sanders S, Rasmussen L, Bostwick JR, Augelli-Szafran C, ... ... Bedwell DM, et al. Triamterene Functions as an Effective Nonsense Suppression Agent for MPS I-H (Hurler Syndrome). International Journal of Molecular Sciences. 24. PMID 36901952 DOI: 10.3390/ijms24054521 |
0.666 |
|
| 2021 |
Sharma J, Du M, Wong E, Mutyam V, Li Y, Chen J, Wangen J, Thrasher K, Fu L, Peng N, Tang L, Liu K, Mathew B, Bostwick RJ, Augelli-Szafran CE, ... ... Bedwell DM, et al. A small molecule that induces translational readthrough of CFTR nonsense mutations by eRF1 depletion. Nature Communications. 12: 4358. PMID 34272367 DOI: 10.1038/s41467-021-24575-x |
0.715 |
|
| 2020 |
Leier A, Bedwell DM, Chen AT, Dickson G, Keeling KM, Kesterson RA, Korf BR, Marquez Lago TT, Müller UF, Popplewell L, Zhou J, Wallis D. Mutation-Directed Therapeutics for Neurofibromatosis Type I. Molecular Therapy. Nucleic Acids. 20: 739-753. PMID 32408052 DOI: 10.1016/J.Omtn.2020.04.012 |
0.706 |
|
| 2020 |
Keeling KM, Bedwell DM. Finding sense in the context. Elife. 9. PMID 32202493 DOI: 10.7554/Elife.55960 |
0.661 |
|
| 2019 |
Bedwell D, Siddiqui A, Dundar H, Echols J, Du M, Rasmussen L, Robert Bostwick J, Suto M, Keeling K. Triamterene normalizes glycosaminoglycan accumulation in an IDUA-W402X mouse model of MPS I (Hurler syndrome) via nonsense suppression Molecular Genetics and Metabolism. 126: S30. DOI: 10.1016/J.Ymgme.2018.12.054 |
0.656 |
|
| 2017 |
Xue X, Mutyam V, Thakerar A, Mobley J, Bridges RJ, Rowe SM, Keeling KM, Bedwell DM. Identification of the Amino Acids Inserted During Suppression of CFTR Nonsense Mutations and Determination of Their Functional Consequences. Human Molecular Genetics. PMID 28575328 DOI: 10.1093/Hmg/Ddx196 |
0.736 |
|
| 2017 |
Bedwell D, Gunn G, Siddiqui A, Du M, Bostwick B, Suto M, Rowe S, Keeling KM. Identification of drugs to treat MPS I caused by nonsense mutations Molecular Genetics and Metabolism. 120: S25. DOI: 10.1016/J.Ymgme.2016.11.035 |
0.702 |
|
| 2016 |
Roy B, Friesen WJ, Tomizawa Y, Leszyk JD, Zhuo J, Johnson B, Dakka J, Trotta CR, Xue X, Mutyam V, Keeling KM, Mobley JA, Rowe SM, Bedwell DM, Welch EM, et al. Ataluren stimulates ribosomal selection of near-cognate tRNAs to promote nonsense suppression. Proceedings of the National Academy of Sciences of the United States of America. PMID 27702906 DOI: 10.1073/Pnas.1605336113 |
0.746 |
|
| 2016 |
Li K, Turner AN, Chen M, Brosius SN, Schoeb TR, Messiaen LM, Bedwell DM, Zinn KR, Anastasaki C, Gutmann DH, Korf BR, Kesterson RA. Mice with missense and nonsense NF1 mutations display divergent phenotypes compared with human neurofibromatosis type I. Disease Models & Mechanisms. 9: 759-767. PMID 27482814 DOI: 10.1242/Dmm.025783 |
0.399 |
|
| 2016 |
Mutyam V, Du M, Xue X, Keeling KM, White EL, Bostwick JR, Rasmussen L, Liu B, Mazur M, Hong JS, Falk Libby E, Liang F, Shang H, Mense M, Suto MJ, ... Bedwell DM, et al. Discovery of Clinically Approved Agents That Promote Suppression of CFTR Nonsense Mutations. American Journal of Respiratory and Critical Care Medicine. PMID 27104944 DOI: 10.1164/Rccm.201601-0154Oc |
0.708 |
|
| 2015 |
Kelly SP, Bedwell DM. Both the autophagy and proteasomal pathways facilitate the Ubp3p-dependent depletion of a subset of translation and RNA turnover factors during nitrogen starvation in Saccharomyces cerevisiae. Rna (New York, N.Y.). 21: 898-910. PMID 25795416 DOI: 10.1261/Rna.045211.114 |
0.358 |
|
| 2015 |
Bedwell DM, Wang D, Welch EM, Keeling KM. The nonsense suppression drug PTC124 restored alpha-l-iduronidase activity and reduces glycosaminoglycan accumulation in MPS IH mice carrying the Idua-W402X mutation Molecular Genetics and Metabolism. 114: S20. DOI: 10.1016/J.Ymgme.2014.12.026 |
0.702 |
|
| 2014 |
Keeling KM, Xue X, Gunn G, Bedwell DM. Therapeutics based on stop codon readthrough. Annual Review of Genomics and Human Genetics. 15: 371-94. PMID 24773318 DOI: 10.1146/Annurev-Genom-091212-153527 |
0.744 |
|
| 2014 |
Tuggle KL, Birket SE, Cui X, Hong J, Warren J, Reid L, Chambers A, Ji D, Gamber K, Chu KK, Tearney G, Tang LP, Fortenberry JA, Du M, Cadillac JM, ... Bedwell DM, et al. Characterization of defects in ion transport and tissue development in cystic fibrosis transmembrane conductance regulator (CFTR)-knockout rats. Plos One. 9: e91253. PMID 24608905 DOI: 10.1371/Journal.Pone.0091253 |
0.308 |
|
| 2014 |
Gunn G, Dai Y, Du M, Belakhov V, Kandasamy J, Schoeb TR, Baasov T, Bedwell DM, Keeling KM. Long-term nonsense suppression therapy moderates MPS I-H disease progression. Molecular Genetics and Metabolism. 111: 374-81. PMID 24411223 DOI: 10.1016/J.Ymgme.2013.12.007 |
0.711 |
|
| 2014 |
Zhang S, Ranganath NK, Skinner D, Bedwell DM, Buckley-Lanier JA, Sorscher EJ, Woodworth BA. Marked repression of CFTR mRNA in the transgenic Cftr(tm1kth) mouse model. Journal of Cystic Fibrosis : Official Journal of the European Cystic Fibrosis Society. 13: 351-2. PMID 24378376 DOI: 10.1016/J.Jcf.2013.11.009 |
0.389 |
|
| 2014 |
Xue X, Mutyam V, Tang L, Biswas S, Du M, Jackson LA, Dai Y, Belakhov V, Shalev M, Chen F, Schacht J, J Bridges R, Baasov T, Hong J, Bedwell DM, et al. Synthetic aminoglycosides efficiently suppress cystic fibrosis transmembrane conductance regulator nonsense mutations and are enhanced by ivacaftor. American Journal of Respiratory Cell and Molecular Biology. 50: 805-16. PMID 24251786 DOI: 10.1165/Rcmb.2013-0282Oc |
0.414 |
|
| 2014 |
Gunn GG, Dai Y, Du M, Beklakhov V, Kandasamy J, Schoeb TR, Baasov T, Bedwell DM, Keeling KM. Long-term nonsense suppression therapy with NB84 moderates MPS IH disease progression Molecular Genetics and Metabolism. 111: S50. DOI: 10.1016/J.Ymgme.2013.12.106 |
0.645 |
|
| 2013 |
Keeling KM, Wang D, Dai Y, Murugesan S, Chenna B, Clark J, Belakhov V, Kandasamy J, Velu SE, Baasov T, Bedwell DM. Attenuation of nonsense-mediated mRNA decay enhances in vivo nonsense suppression. Plos One. 8: e60478. PMID 23593225 DOI: 10.1371/Journal.Pone.0060478 |
0.751 |
|
| 2012 |
Keeling KM, Wang D, Conard SE, Bedwell DM. Suppression of premature termination codons as a therapeutic approach. Critical Reviews in Biochemistry and Molecular Biology. 47: 444-63. PMID 22672057 DOI: 10.3109/10409238.2012.694846 |
0.801 |
|
| 2012 |
Conard SE, Buckley J, Dang M, Bedwell GJ, Carter RL, Khass M, Bedwell DM. Identification of eRF1 residues that play critical and complementary roles in stop codon recognition Rna. 18: 1210-1221. PMID 22543865 DOI: 10.1261/Rna.031997.111 |
0.809 |
|
| 2012 |
Wang D, Belakhov V, Kandasamy J, Baasov T, Li SC, Li YT, Bedwell DM, Keeling KM. The designer aminoglycoside NB84 significantly reduces glycosaminoglycan accumulation associated with MPS I-H in the Idua-W392X mouse. Molecular Genetics and Metabolism. 105: 116-25. PMID 22056610 DOI: 10.1016/J.Ymgme.2011.10.005 |
0.735 |
|
| 2011 |
Keeling KM, Bedwell DM. Suppression of nonsense mutations as a therapeutic approach to treat genetic diseases. Wiley Interdisciplinary Reviews. Rna. 2: 837-52. PMID 21976286 DOI: 10.1002/Wrna.95 |
0.729 |
|
| 2011 |
Rowe SM, Sloane P, Tang LP, Backer K, Mazur M, Buckley-Lanier J, Nudelman I, Belakhov V, Bebok Z, Schwiebert E, Baasov T, Bedwell DM. Suppression of CFTR premature termination codons and rescue of CFTR protein and function by the synthetic aminoglycoside NB54. Journal of Molecular Medicine (Berlin, Germany). 89: 1149-61. PMID 21779978 DOI: 10.1007/S00109-011-0787-6 |
0.348 |
|
| 2011 |
Lazrak A, Jurkuvenaite A, Chen L, Keeling KM, Collawn JF, Bedwell DM, Matalon S. Enhancement of alveolar epithelial sodium channel activity with decreased cystic fibrosis transmembrane conductance regulator expression in mouse lung. American Journal of Physiology. Lung Cellular and Molecular Physiology. 301: L557-67. PMID 21743028 DOI: 10.1152/Ajplung.00094.2011 |
0.653 |
|
| 2010 |
Wang D, Shukla C, Liu X, Schoeb TR, Clarke LA, Bedwell DM, Keeling KM. Characterization of an MPS I-H knock-in mouse that carries a nonsense mutation analogous to the human IDUA-W402X mutation. Molecular Genetics and Metabolism. 99: 62-71. PMID 19751987 DOI: 10.1016/J.Ymgme.2009.08.002 |
0.721 |
|
| 2010 |
Wang D, Shukla C, Liu X, Schoeb TR, Clarke LA, Bedwell DM, Keeling KM. Corrigendum to "Characterization of an MPS I-H knock-in mouse that carries a nonsense mutation analogous to the human IDUA-W402X mutation" [Mol. Genet. Metab. 99 (2010) 62-71] (DOI:10.1016/j.ymgme.2009.08.002) Molecular Genetics and Metabolism. 99: 439. DOI: 10.1016/J.Ymgme.2009.12.013 |
0.725 |
|
| 2009 |
Vallabhaneni H, Fan-Minogue H, Bedwell DM, Farabaugh PJ. Connection between stop codon reassignment and frequent use of shifty stop frameshifting. Rna (New York, N.Y.). 15: 889-97. PMID 19329535 DOI: 10.1261/Rna.1508109 |
0.817 |
|
| 2009 |
Du M, Keeling KM, Fan L, Liu X, Bedwell DM. Poly-L-aspartic acid enhances and prolongs gentamicin-mediated suppression of the CFTR-G542X mutation in a cystic fibrosis mouse model. The Journal of Biological Chemistry. 284: 6885-92. PMID 19136563 DOI: 10.1074/Jbc.M806728200 |
0.738 |
|
| 2009 |
Bedwell D, Wang D, Shukla C, Liu X, Yeh S, Welch E, Schoeb T, Keeling K. 12. Suppression of a nonsense mutation in a mouse model of Hurler syndrome Molecular Genetics and Metabolism. 96: S14. DOI: 10.1016/J.Ymgme.2008.11.013 |
0.719 |
|
| 2008 |
Fan-Minogue H, Du M, Pisarev AV, Kallmeyer AK, Salas-Marco J, Keeling KM, Thompson SR, Pestova TV, Bedwell DM. Distinct eRF3 requirements suggest alternate eRF1 conformations mediate peptide release during eukaryotic translation termination. Molecular Cell. 30: 599-609. PMID 18538658 DOI: 10.1016/J.Molcel.2008.03.020 |
0.753 |
|
| 2008 |
Du M, Liu X, Welch EM, Hirawat S, Peltz SW, Bedwell DM. PTC124 is an orally bioavailable compound that promotes suppression of the human CFTR-G542X nonsense allele in a CF mouse model. Proceedings of the National Academy of Sciences of the United States of America. 105: 2064-9. PMID 18272502 DOI: 10.1073/Pnas.0711795105 |
0.434 |
|
| 2008 |
Fan-Minogue H, Bedwell DM. Eukaryotic ribosomal RNA determinants of aminoglycoside resistance and their role in translational fidelity. Rna (New York, N.Y.). 14: 148-57. PMID 18003936 DOI: 10.1261/Rna.805208 |
0.772 |
|
| 2006 |
Kallmeyer AK, Keeling KM, Bedwell DM. Eukaryotic release factor 1 phosphorylation by CK2 protein kinase is dynamic but has little effect on the efficiency of translation termination in Saccharomyces cerevisiae. Eukaryotic Cell. 5: 1378-87. PMID 16896221 DOI: 10.1128/Ec.00073-06 |
0.759 |
|
| 2006 |
Keeling KM, Salas-Marco J, Osherovich LZ, Bedwell DM. Tpa1p is part of an mRNP complex that influences translation termination, mRNA deadenylation, and mRNA turnover in Saccharomyces cerevisiae. Molecular and Cellular Biology. 26: 5237-48. PMID 16809762 DOI: 10.1128/Mcb.02448-05 |
0.791 |
|
| 2006 |
Du M, Keeling KM, Fan L, Liu X, Kovaçs T, Sorscher E, Bedwell DM. Clinical doses of amikacin provide more effective suppression of the human CFTR-G542X stop mutation than gentamicin in a transgenic CF mouse model. Journal of Molecular Medicine (Berlin, Germany). 84: 573-82. PMID 16541275 DOI: 10.1007/S00109-006-0045-5 |
0.719 |
|
| 2006 |
Kellermayer R, Szigeti R, Keeling KM, Bedekovics T, Bedwell DM. Aminoglycosides as potential pharmacogenetic agents in the treatment of Hailey-Hailey disease. The Journal of Investigative Dermatology. 126: 229-31. PMID 16417242 DOI: 10.1038/Sj.Jid.5700031 |
0.636 |
|
| 2006 |
Salas-Marco J, Fan-Minogue H, Kallmeyer AK, Klobutcher LA, Farabaugh PJ, Bedwell DM. Distinct paths to stop codon reassignment by the variant-code organisms Tetrahymena and Euplotes. Molecular and Cellular Biology. 26: 438-47. PMID 16382136 DOI: 10.1128/Mcb.26.2.438-447.2006 |
0.747 |
|
| 2005 |
Salas-Marco J, Bedwell DM. Discrimination between defects in elongation fidelity and termination efficiency provides mechanistic insights into translational readthrough. Journal of Molecular Biology. 348: 801-15. PMID 15843014 DOI: 10.1016/J.Jmb.2005.03.025 |
0.817 |
|
| 2005 |
Csutora P, Strassz A, Boldizsár F, Németh P, Sipos K, Aiello DP, Bedwell DM, Miseta A. Inhibition of phosphoglucomutase activity by lithium alters cellular calcium homeostasis and signaling in Saccharomyces cerevisiae. American Journal of Physiology. Cell Physiology. 289: C58-67. PMID 15703203 DOI: 10.1152/Ajpcell.00464.2004 |
0.757 |
|
| 2005 |
Bedwell D. Eukaryotic Translation Termination Reactome - a Curated Knowledgebase of Biological Pathways. 12. DOI: 10.3180/React_1986.1 |
0.385 |
|
| 2005 |
Keeling KM, Bedwell DM. Pharmacological suppression of premature stop mutations that cause genetic diseases Current Pharmacogenomics. 3: 259-269. DOI: 10.2174/157016005774913149 |
0.746 |
|
| 2004 |
Salas-Marco J, Bedwell DM. GTP hydrolysis by eRF3 facilitates stop codon decoding during eukaryotic translation termination. Molecular and Cellular Biology. 24: 7769-78. PMID 15314182 DOI: 10.1128/Mcb.24.17.7769-7778.2004 |
0.805 |
|
| 2004 |
Aiello DP, Fu L, Miseta A, Sipos K, Bedwell DM. The Ca2+ homeostasis defects in a pgm2Delta strain of Saccharomyces cerevisiae are caused by excessive vacuolar Ca2+ uptake mediated by the Ca2+-ATPase Pmc1p. The Journal of Biological Chemistry. 279: 38495-502. PMID 15252028 DOI: 10.1074/Jbc.M400833200 |
0.767 |
|
| 2004 |
Keeling KM, Lanier J, Du M, Salas-Marco J, Gao L, Kaenjak-Angeletti A, Bedwell DM. Leaky termination at premature stop codons antagonizes nonsense-mediated mRNA decay in S. cerevisiae. Rna (New York, N.Y.). 10: 691-703. PMID 15037778 DOI: 10.1261/Rna.5147804 |
0.809 |
|
| 2003 |
Miseta A, Tökés-Füzesi M, Aiello DP, Bedwell DM. A Saccharomyces cerevisiae mutant unable to convert glucose to glucose-6-phosphate accumulates excessive glucose in the endoplasmic reticulum due to core oligosaccharide trimming. Eukaryotic Cell. 2: 534-41. PMID 12796298 DOI: 10.1128/Ec.2.3.534-541.2003 |
0.757 |
|
| 2003 |
Kellermayer R, Aiello DP, Miseta A, Bedwell DM. Extracellular Ca(2+) sensing contributes to excess Ca(2+) accumulation and vacuolar fragmentation in a pmr1Delta mutant of S. cerevisiae. Journal of Cell Science. 116: 1637-46. PMID 12640047 DOI: 10.1242/Jcs.00372 |
0.757 |
|
| 2002 |
Aiello DP, Fu L, Miseta A, Bedwell DM. Intracellular glucose 1-phosphate and glucose 6-phosphate levels modulate Ca2+ homeostasis in Saccharomyces cerevisiae. The Journal of Biological Chemistry. 277: 45751-8. PMID 12351653 DOI: 10.1074/Jbc.M208748200 |
0.758 |
|
| 2002 |
Du M, Jones JR, Lanier J, Keeling KM, Lindsey JR, Tousson A, Bebök Z, Whitsett JA, Dey CR, Colledge WH, Evans MJ, Sorscher EJ, Bedwell DM. Aminoglycoside suppression of a premature stop mutation in a Cftr-/- mouse carrying a human CFTR-G542X transgene. Journal of Molecular Medicine (Berlin, Germany). 80: 595-604. PMID 12226741 DOI: 10.1007/S00109-002-0363-1 |
0.738 |
|
| 2002 |
Keeling KM, Bedwell DM. Clinically relevant aminoglycosides can suppress disease-associated premature stop mutations in the IDUA and P53 cDNAs in a mammalian translation system. Journal of Molecular Medicine (Berlin, Germany). 80: 367-76. PMID 12072912 DOI: 10.1007/S00109-001-0317-Z |
0.754 |
|
| 2001 |
Koh JY, Hájek P, Bedwell DM. Overproduction of PDR3 suppresses mitochondrial import defects associated with a TOM70 null mutation by increasing the expression of TOM72 in Saccharomyces cerevisiae. Molecular and Cellular Biology. 21: 7576-86. PMID 11604494 DOI: 10.1128/Mcb.21.22.7576-7586.2001 |
0.545 |
|
| 2001 |
Clancy JP, Bebök Z, Ruiz F, King C, Jones J, Walker L, Greer H, Hong J, Wing L, Macaluso M, Lyrene R, Sorscher EJ, Bedwell DM. Evidence that systemic gentamicin suppresses premature stop mutations in patients with cystic fibrosis. American Journal of Respiratory and Critical Care Medicine. 163: 1683-92. PMID 11401894 DOI: 10.1164/Ajrccm.163.7.2004001 |
0.354 |
|
| 2001 |
Keeling KM, Brooks DA, Hopwood JJ, Li P, Thompson JN, Bedwell DM. Gentamicin-mediated suppression of Hurler syndrome stop mutations restores a low level of alpha-L-iduronidase activity and reduces lysosomal glycosaminoglycan accumulation. Human Molecular Genetics. 10: 291-9. PMID 11159948 DOI: 10.1093/Hmg/10.3.291 |
0.71 |
|
| 2000 |
Manuvakhova M, Keeling K, Bedwell DM. Aminoglycoside antibiotics mediate context-dependent suppression of termination codons in a mammalian translation system Rna. 6: 1044-1055. PMID 10917599 DOI: 10.1017/S1355838200000716 |
0.736 |
|
| 1999 |
Meacham GC, Browne BL, Zhang W, Kellermayer R, Bedwell DM, Cyr DM. Mutations in the yeast Hsp40 chaperone protein Ydj1 cause defects in Axl1 biogenesis and pro-a-factor processing. The Journal of Biological Chemistry. 274: 34396-402. PMID 10567418 DOI: 10.1074/Jbc.274.48.34396 |
0.754 |
|
| 1999 |
Miseta A, Kellermayer R, Aiello DP, Fu L, Bedwell DM. The vacuolar Ca2+/H+ exchanger Vcx1p/Hum1p tightly controls cytosolic Ca2+ levels in S. cerevisiae. Febs Letters. 451: 132-6. PMID 10371152 DOI: 10.1016/S0014-5793(99)00519-0 |
0.749 |
|
| 1998 |
Clancy JP, Hong JS, Bebök Z, King SA, Demolombe S, Bedwell DM, Sorscher EJ. Cystic fibrosis transmembrane conductance regulator (CFTR) nucleotide-binding domain 1 (NBD-1) and CFTR truncated within NBD-1 target to the epithelial plasma membrane and increase anion permeability. Biochemistry. 37: 15222-30. PMID 9790686 DOI: 10.1021/Bi980436F |
0.345 |
|
| 1998 |
Bedwell DM, Kaenjak A, Keeling K, Manouvakhova M, Bebok Z, Benos D, Bubien J, Schwiebert E, Clancy JP, Ruiz F, Sorscher E. Aminoglycoside repair of premature translation termination mutations Pediatric Pulmonology. 26: 168. |
0.331 |
|
| 1997 |
Hájek P, Koh JY, Jones L, Bedwell DM. The amino terminus of the F1-ATPase beta-subunit precursor functions as an intramolecular chaperone to facilitate mitochondrial protein import. Molecular and Cellular Biology. 17: 7169-77. PMID 9372949 DOI: 10.1128/Mcb.17.12.7169 |
0.583 |
|
| 1997 |
Bedwell DM, Kaenjak A, Benos DJ, Bebok Z, Bubien JK, Hong J, Tousson A, Clancy JP, Sorscher EJ. Suppression of a CFTR premature stop mutation in a bronchial epithelial cell line. Nature Medicine. 3: 1280-4. PMID 9359706 DOI: 10.1038/Nm1197-1280 |
0.434 |
|
| 1996 |
Browne BL, McClendon V, Bedwell DM. Mutations within the first LSGGQ motif of Ste6p cause defects in a-factor transport and mating in Saccharomyces cerevisiae. Journal of Bacteriology. 178: 1712-9. PMID 8626301 DOI: 10.1128/Jb.178.6.1712-1719.1996 |
0.755 |
|
| 1996 |
Howard M, Frizzell RA, Bedwell DM. Aminoglycoside antibiotics restore CFTR function by overcoming premature stop mutations Nature Medicine. 2: 467-469. PMID 8597960 DOI: 10.1038/Nm0496-467 |
0.42 |
|
| 1995 |
Fu L, Bounelis P, Dey N, Browne BL, Marchase RB, Bedwell DM. The posttranslational modification of phosphoglucomutase is regulated by galactose induction and glucose repression in Saccharomyces cerevisiae. Journal of Bacteriology. 177: 3087-94. PMID 7768805 DOI: 10.1128/Jb.177.11.3087-3094.1995 |
0.714 |
|
| 1995 |
Bonetti B, Fu L, Moon J, Bedwell DM. The efficiency of translation termination is determined by a synergistic interplay between upstream and downstream sequences in Saccharomyces cerevisiae Journal of Molecular Biology. 251: 334-345. PMID 7650736 DOI: 10.1006/Jmbi.1995.0438 |
0.396 |
|
| 1994 |
Fearon K, McClendon V, Bonetti B, Bedwell DM. Premature translation termination mutations are efficiently suppressed in a highly conserved region of yeast Ste6p, a member of the ATP-binding cassette (ABC) transporter family Journal of Biological Chemistry. 269: 17802-17808. PMID 7517933 |
0.394 |
|
| 1989 |
Bedwell DM, Strobel SA, Yun K, Jongeward GD, Emr SD. Sequence and structural requirements of a mitochondrial protein import signal defined by saturation cassette mutagenesis. Molecular and Cellular Biology. 9: 1014-25. PMID 2524645 DOI: 10.1128/Mcb.9.3.1014 |
0.427 |
|
| 1987 |
Thomas MS, Bedwell DM, Nomura M. Regulation of α operon gene expression in Escherichia coli. A novel form of translational coupling Journal of Molecular Biology. 196: 333-345. PMID 3309351 DOI: 10.1016/0022-2836(87)90694-2 |
0.308 |
|
| 1987 |
Bedwell DM, Klionsky DJ, Emr SD. The yeast F1-ATPase beta subunit precursor contains functionally redundant mitochondrial protein import information Molecular and Cellular Biology. 7: 4038-4047. PMID 2893254 DOI: 10.1128/Mcb.7.11.4038 |
0.323 |
|
| 1985 |
Takebe Y, Miura A, Bedwell DM, Tam M, Nomura M. Increased expression of ribosomal genes during inhibition of ribosome assembly in Escherichia coli Journal of Molecular Biology. 184: 23-30. PMID 3897554 DOI: 10.1016/0022-2836(85)90040-3 |
0.333 |
|
| 1980 |
Koduri RK, Bedwell DM, Brenchley JE. Characterization of a HindIII generated DNA fragment carrying the glutamine synthetase gene of Salmonella typhimurium Gene. 11: 227-237. PMID 6111515 DOI: 10.1016/0378-1119(80)90063-3 |
0.372 |
|
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