Arlene H. Sharpe - Publications

Harvard University, Cambridge, MA, United States 
Cell Biology, Microbiology Biology

242 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any innacuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2019 Paz K, Flynn R, Du J, Tannheimer S, Johnson AJ, Dong S, Stark AK, Okkenhaug K, Panoskaltsis-Mortari A, Sage PT, Sharpe AH, Luznik L, Ritz J, Soiffer RJ, Cutler CS, et al. Targeting PI3Kδ Function For Amelioration of Murine Chronic Graft-Versus-Host Disease. American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons. PMID 30748099 DOI: 10.1111/ajt.15305  0.76
2019 Hou S, Clement RL, Diallo A, Blazar BR, Rudensky AY, Sharpe AH, Sage PT. FoxP3 and Ezh2 regulate Tfr cell suppressive function and transcriptional program. The Journal of Experimental Medicine. PMID 30705058 DOI: 10.1084/jem.20181134  0.76
2018 Ron-Harel N, Notarangelo G, Ghergurovich JM, Paulo JA, Sage PT, Santos D, Satterstrom FK, Gygi SP, Rabinowitz JD, Sharpe AH, Haigis MC. Defective respiration and one-carbon metabolism contribute to impaired naïve T cell activation in aged mice. Proceedings of the National Academy of Sciences of the United States of America. 115: 13347-13352. PMID 30530686 DOI: 10.1073/pnas.1804149115  0.76
2018 Paz K, Flynn R, Du J, Qi J, Luznik L, Maillard I, MacDonald KP, Hill GR, Serody JS, Murphy WJ, Sage PT, Sharpe AH, Miklos D, Culter CS, Koreth J, et al. Small-molecule BCL6 inhibitor effectively treats mice with non-sclerodermatous chronic graft-versus-host disease. Blood. PMID 30279226 DOI: 10.1182/blood-2018-03-839993  0.76
2018 Sage PT, Schildberg FA, Sobel RA, Kuchroo VK, Freeman GJ, Sharpe AH. Dendritic Cell PD-L1 Limits Autoimmunity and Follicular T Cell Differentiation and Function. Journal of Immunology (Baltimore, Md. : 1950). PMID 29531164 DOI: 10.4049/jimmunol.1701231  0.76
2018 Zhang R, Sage PT, Finn K, Huynh A, Blazar BR, Marangoni F, Mempel TR, Sharpe AH, Turka LA. Correction: B Cells Drive Autoimmunity in Mice with CD28-Deficient Regulatory T Cells. Journal of Immunology (Baltimore, Md. : 1950). PMID 29475985 DOI: 10.4049/jimmunol.1800150  0.76
2017 Zhang R, Sage PT, Finn K, Huynh A, Blazar BR, Marangoni F, Mempel TR, Sharpe AH, Turka LA. B Cells Drive Autoimmunity in Mice with CD28-Deficient Regulatory T Cells. Journal of Immunology (Baltimore, Md. : 1950). PMID 29093061 DOI: 10.4049/jimmunol.1700409  0.76
2016 Sage PT, Ron-Harel N, Juneja VR, Sen DR, Maleri S, Sungnak W, Kuchroo VK, Haining WN, Chevrier N, Haigis M, Sharpe AH. Suppression by TFR cells leads to durable and selective inhibition of B cell effector function. Nature Immunology. PMID 27695002 DOI: 10.1038/ni.3578  0.76
2016 McArdel SL, Brown DR, Sobel RA, Sharpe AH. Anti-CD48 Monoclonal Antibody Attenuates Experimental Autoimmune Encephalomyelitis by Limiting the Number of Pathogenic CD4+ T Cells. Journal of Immunology (Baltimore, Md. : 1950). PMID 27581174 DOI: 10.4049/jimmunol.1600706  0.76
2016 Ron-Harel N, Santos D, Ghergurovich JM, Sage PT, Reddy A, Lovitch SB, Dephoure N, Satterstrom FK, Sheffer M, Spinelli JB, Gygi S, Rabinowitz JD, Sharpe AH, Haigis MC. Mitochondrial Biogenesis and Proteome Remodeling Promote One-Carbon Metabolism for T Cell Activation. Cell Metabolism. 24: 104-17. PMID 27411012 DOI: 10.1016/j.cmet.2016.06.007  0.76
2016 Schildberg FA, Klein SR, Freeman GJ, Sharpe AH. Coinhibitory Pathways in the B7-CD28 Ligand-Receptor Family. Immunity. 44: 955-972. PMID 27192563 DOI: 10.1016/j.immuni.2016.05.002  0.76
2016 Sage PT, Sharpe AH. T follicular regulatory cells. Immunological Reviews. 271: 246-59. PMID 27088919 DOI: 10.1111/imr.12411  0.76
2016 Baumeister SH, Freeman GJ, Dranoff G, Sharpe AH. Coinhibitory Pathways in Immunotherapy for Cancer. Annual Review of Immunology. PMID 26927206 DOI: 10.1146/annurev-immunol-032414-112049  0.76
2016 McArdel SL, Terhorst C, Sharpe AH. Roles of CD48 in regulating immunity and tolerance. Clinical Immunology (Orlando, Fla.). 164: 10-20. PMID 26794910 DOI: 10.1016/j.clim.2016.01.008  0.76
2015 Sharma MD, Shinde R, McGaha TL, Huang L, Holmgaard RB, Wolchok JD, Mautino MR, Celis E, Sharpe AH, Francisco LM, Powell JD, Yagita H, Mellor AL, Blazar BR, Munn DH. The PTEN pathway in Tregs is a critical driver of the suppressive tumor microenvironment. Science Advances. 1: e1500845. PMID 26601142 DOI: 10.1126/sciadv.1500845  0.44
2015 Paterson AM, Lovitch SB, Sage PT, Juneja VR, Lee Y, Trombley JD, Arancibia-Cárcamo CV, Sobel RA, Rudensky AY, Kuchroo VK, Freeman GJ, Sharpe AH. Deletion of CTLA-4 on regulatory T cells during adulthood leads to resistance to autoimmunity. The Journal of Experimental Medicine. 212: 1603-21. PMID 26371185 DOI: 10.1084/jem.20141030  0.76
2015 Kleffel S, Posch C, Barthel SR, Mueller H, Schlapbach C, Guenova E, Elco CP, Lee N, Juneja VR, Zhan Q, Lian CG, Thomi R, Hoetzenecker W, Cozzio A, Dummer R, ... ... Sharpe AH, et al. Melanoma Cell-Intrinsic PD-1 Receptor Functions Promote Tumor Growth. Cell. 162: 1242-56. PMID 26359984 DOI: 10.1016/j.cell.2015.08.052  0.6
2015 Schatton T, Yang J, Kleffel S, Uehara M, Barthel SR, Schlapbach C, Zhan Q, Dudeney S, Mueller H, Lee N, de Vries JC, Meier B, Vander Beken S, Kluth MA, Ganss C, ... Sharpe AH, et al. ABCB5 Identifies Immunoregulatory Dermal Cells. Cell Reports. 12: 1564-74. PMID 26321644 DOI: 10.1016/j.celrep.2015.08.010  0.6
2015 Sage PT, Tan CL, Freeman GJ, Haigis M, Sharpe AH. Defective TFH Cell Function and Increased TFR Cells Contribute to Defective Antibody Production in Aging. Cell Reports. 12: 163-71. PMID 26146074 DOI: 10.1016/j.celrep.2015.06.015  0.76
2015 Sage PT, Sharpe AH. T follicular regulatory cells in the regulation of B cell responses. Trends in Immunology. 36: 410-8. PMID 26091728 DOI: 10.1016/  0.76
2015 Sage PT, Sharpe AH. In vitro assay to sensitively measure T(FR) suppressive capacity and T(FH) stimulation of B cell responses. Methods in Molecular Biology (Clifton, N.J.). 1291: 151-60. PMID 25836309 DOI: 10.1007/978-1-4939-2498-1_13  0.6
2015 Maazi H, Patel N, Sankaranarayanan I, Suzuki Y, Rigas D, Soroosh P, Freeman GJ, Sharpe AH, Akbari O. ICOS:ICOS-ligand interaction is required for type 2 innate lymphoid cell function, homeostasis, and induction of airway hyperreactivity. Immunity. 42: 538-51. PMID 25769613 DOI: 10.1016/j.immuni.2015.02.007  0.76
2015 Huynh A, DuPage M, Priyadharshini B, Sage PT, Quiros J, Borges CM, Townamchai N, Gerriets VA, Rathmell JC, Sharpe AH, Bluestone JA, Turka LA. Control of PI(3) kinase in Treg cells maintains homeostasis and lineage stability. Nature Immunology. 16: 188-96. PMID 25559257 DOI: 10.1038/ni.3077  0.76
2015 Godec J, Cowley GS, Barnitz RA, Alkan O, Root DE, Sharpe AH, Haining WN. Inducible RNAi in vivo reveals that the transcription factor BATF is required to initiate but not maintain CD8+ T-cell effector differentiation. Proceedings of the National Academy of Sciences of the United States of America. 112: 512-7. PMID 25548173 DOI: 10.1073/pnas.1413291112  0.76
2014 Sage PT, Paterson AM, Lovitch SB, Sharpe AH. The coinhibitory receptor CTLA-4 controls B cell responses by modulating T follicular helper, T follicular regulatory, and T regulatory cells. Immunity. 41: 1026-39. PMID 25526313 DOI: 10.1016/j.immuni.2014.12.005  0.76
2014 Topalian SL, Sharpe AH. Balance and imbalance in the immune system: life on the edge. Immunity. 41: 682-4. PMID 25517610 DOI: 10.1016/j.immuni.2014.11.005  0.76
2014 Sage PT, Alvarez D, Godec J, von Andrian UH, Sharpe AH. Circulating T follicular regulatory and helper cells have memory-like properties. The Journal of Clinical Investigation. 124: 5191-204. PMID 25347469 DOI: 10.1172/JCI76861  0.76
2014 Penaloza-MacMaster P, Kamphorst AO, Wieland A, Araki K, Iyer SS, West EE, O'Mara L, Yang S, Konieczny BT, Sharpe AH, Freeman GJ, Rudensky AY, Ahmed R. Interplay between regulatory T cells and PD-1 in modulating T cell exhaustion and viral control during chronic LCMV infection. The Journal of Experimental Medicine. 211: 1905-18. PMID 25113973 DOI: 10.1084/jem.20132577  0.76
2014 Wolf AI, Strauman MC, Mozdzanowska K, Whittle JR, Williams KL, Sharpe AH, Weiser JN, Caton AJ, Hensley SE, Erikson J. Coinfection with Streptococcus pneumoniae modulates the B cell response to influenza virus. Journal of Virology. 88: 11995-2005. PMID 25100838 DOI: 10.1128/JVI.01833-14  0.76
2014 Cooper ZA, Juneja VR, Sage PT, Frederick DT, Piris A, Mitra D, Lo JA, Hodi FS, Freeman GJ, Bosenberg MW, McMahon M, Flaherty KT, Fisher DE, Sharpe AH, Wargo JA. Response to BRAF inhibition in melanoma is enhanced when combined with immune checkpoint blockade. Cancer Immunology Research. 2: 643-54. PMID 24903021 DOI: 10.1158/2326-6066.CIR-13-0215  0.76
2014 Xiao Y, Yu S, Zhu B, Bedoret D, Bu X, Francisco LM, Hua P, Duke-Cohan JS, Umetsu DT, Sharpe AH, DeKruyff RH, Freeman GJ. RGMb is a novel binding partner for PD-L2 and its engagement with PD-L2 promotes respiratory tolerance. The Journal of Experimental Medicine. 211: 943-59. PMID 24752301 DOI: 10.1084/jem.20130790  0.44
2014 Joller N, Lozano E, Burkett PR, Patel B, Xiao S, Zhu C, Xia J, Tan TG, Sefik E, Yajnik V, Sharpe AH, Quintana FJ, Mathis D, Benoist C, Hafler DA, et al. Treg cells expressing the coinhibitory molecule TIGIT selectively inhibit proinflammatory Th1 and Th17 cell responses. Immunity. 40: 569-81. PMID 24745333 DOI: 10.1016/j.immuni.2014.02.012  0.76
2014 Mott KR, Allen SJ, Zandian M, Akbari O, Hamrah P, Maazi H, Wechsler SL, Sharpe AH, Freeman GJ, Ghiasi H. Inclusion of CD80 in HSV targets the recombinant virus to PD-L1 on DCs and allows productive infection and robust immune responses. Plos One. 9: e87617. PMID 24475315 DOI: 10.1371/journal.pone.0087617  0.76
2014 Chiang HS, Zhao Y, Song JH, Liu S, Wang N, Terhorst C, Sharpe AH, Basavappa M, Jeffrey KL, Reinecker HC. GEF-H1 controls microtubule-dependent sensing of nucleic acids for antiviral host defenses. Nature Immunology. 15: 63-71. PMID 24270516 DOI: 10.1038/ni.2766  0.76
2014 Sage PT, Paterson AM, Lovitch SB, Sharpe AH. The coinhibitory receptor CTLA-4 controls B cell responses by modulating T follicular helper, T follicular regulatory, and T regulatory cells Immunity. 41: 1026-1039. DOI: 10.1016/j.immuni.2014.12.005  0.76
2013 Cooper ZA, Frederick DT, Juneja VR, Sullivan RJ, Lawrence DP, Piris A, Sharpe AH, Fisher DE, Flaherty KT, Wargo JA. BRAF inhibition is associated with increased clonality in tumor-infiltrating lymphocytes. Oncoimmunology. 2: e26615. PMID 24251082 DOI: 10.4161/onci.26615  0.76
2013 Saha A, Aoyama K, Taylor PA, Koehn BH, Veenstra RG, Panoskaltsis-Mortari A, Munn DH, Murphy WJ, Azuma M, Yagita H, Fife BT, Sayegh MH, Najafian N, Socie G, Ahmed R, ... ... Sharpe AH, et al. Host programmed death ligand 1 is dominant over programmed death ligand 2 expression in regulating graft-versus-host disease lethality. Blood. 122: 3062-73. PMID 24030385 DOI: 10.1182/blood-2013-05-500801  0.76
2013 Fuller MJ, Callendret B, Zhu B, Freeman GJ, Hasselschwert DL, Satterfield W, Sharpe AH, Dustin LB, Rice CM, Grakoui A, Ahmed R, Walker CM. Immunotherapy of chronic hepatitis C virus infection with antibodies against programmed cell death-1 (PD-1). Proceedings of the National Academy of Sciences of the United States of America. 110: 15001-6. PMID 23980172 DOI: 10.1073/pnas.1312772110  0.76
2013 Laurent G, German NJ, Saha AK, de Boer VC, Davies M, Koves TR, Dephoure N, Fischer F, Boanca G, Vaitheesvaran B, Lovitch SB, Sharpe AH, Kurland IJ, Steegborn C, Gygi SP, et al. SIRT4 coordinates the balance between lipid synthesis and catabolism by repressing malonyl CoA decarboxylase. Molecular Cell. 50: 686-98. PMID 23746352 DOI: 10.1016/j.molcel.2013.05.012  0.76
2013 Maazi H, Singh AK, Speak AO, Lombardi V, Lam J, Khoo B, Inn KS, Sharpe AH, Jung JU, Akbari O. Lack of PD-L1 expression by iNKT cells improves the course of influenza A infection. Plos One. 8: e59599. PMID 23555047 DOI: 10.1371/journal.pone.0059599  0.76
2013 Chang SY, Song JH, Guleng B, Cotoner CA, Arihiro S, Zhao Y, Chiang HS, O'Keeffe M, Liao G, Karp CL, Kweon MN, Sharpe AH, Bhan A, Terhorst C, Reinecker HC. Circulatory antigen processing by mucosal dendritic cells controls CD8(+) T cell activation. Immunity. 38: 153-65. PMID 23246312 DOI: 10.1016/j.immuni.2012.09.018  0.76
2013 Sage PT, Francisco LM, Carman CV, Sharpe AH. The receptor PD-1 controls follicular regulatory T cells in the lymph nodes and blood. Nature Immunology. 14: 152-61. PMID 23242415 DOI: 10.1038/ni.2496  0.76
2012 Riella LV, Paterson AM, Sharpe AH, Chandraker A. Role of the PD-1 pathway in the immune response American Journal of Transplantation. 12: 2575-2587. PMID 22900886 DOI: 10.1111/j.1600-6143.2012.04224.x  0.76
2012 Butte MJ, Lee SJ, Jesneck J, Keir ME, Haining WN, Sharpe AH. CD28 costimulation regulates genome-wide effects on alternative splicing. Plos One. 7: e40032. PMID 22768209 DOI: 10.1371/journal.pone.0040032  0.76
2012 Hirahara K, Ghoreschi K, Yang XP, Takahashi H, Laurence A, Vahedi G, Sciumè G, Hall AO, Dupont CD, Francisco LM, Chen Q, Tanaka M, Kanno Y, Sun HW, Sharpe AH, et al. Interleukin-27 priming of T cells controls IL-17 production in trans via induction of the ligand PD-L1. Immunity. 36: 1017-30. PMID 22726954 DOI: 10.1016/j.immuni.2012.03.024  0.76
2012 Sham CW, Chan AM, Kwong JM, Caprioli J, Nusinowitz S, Chen B, Lee JG, Gandhi NM, Francisco LM, Sharpe AH, Chen L, Braun J, Gordon LK. Neuronal programmed cell death-1 ligand expression regulates retinal ganglion cell number in neonatal and adult mice. Journal of Neuro-Ophthalmology : the Official Journal of the North American Neuro-Ophthalmology Society. 32: 227-37. PMID 22635166 DOI: 10.1097/WNO.0b013e3182589589  0.76
2012 Tarrio ML, Grabie N, Bu DX, Sharpe AH, Lichtman AH. PD-1 protects against inflammation and myocyte damage in T cell-mediated myocarditis. Journal of Immunology (Baltimore, Md. : 1950). 188: 4876-84. PMID 22491251 DOI: 10.4049/jimmunol.1200389  0.76
2012 Good-Jacobson KL, Song E, Anderson S, Sharpe AH, Shlomchik MJ. CD80 expression on B cells regulates murine T follicular helper development, germinal center B cell survival, and plasma cell generation. Journal of Immunology (Baltimore, Md. : 1950). 188: 4217-25. PMID 22450810 DOI: 10.4049/jimmunol.1102885  0.76
2012 Sage PT, Varghese LM, Martinelli R, Sciuto TE, Kamei M, Dvorak AM, Springer TA, Sharpe AH, Carman CV. Antigen recognition is facilitated by invadosome-like protrusions formed by memory/effector T cells. Journal of Immunology (Baltimore, Md. : 1950). 188: 3686-99. PMID 22442443 DOI: 10.4049/jimmunol.1102594  0.76
2012 Vijayanand P, Seumois G, Simpson LJ, Abdul-Wajid S, Baumjohann D, Panduro M, Huang X, Interlandi J, Djuretic IM, Brown DR, Sharpe AH, Rao A, Ansel KM. Interleukin-4 production by follicular helper T cells requires the conserved Il4 enhancer hypersensitivity site V. Immunity. 36: 175-87. PMID 22326582 DOI: 10.1016/j.immuni.2011.12.014  0.76
2012 Freeman GJ, Sharpe AH. A new therapeutic strategy for malaria: targeting T cell exhaustion. Nature Immunology. 13: 113-5. PMID 22261959 DOI: 10.1038/ni.2211  0.76
2012 Liu SM, Sutherland APR, Zhang Z, Rainbow DB, Quintana FJ, Paterson AM, Sharpe AH, Oukka M, Wicker LS, Kuchroo VK. Overexpression of the CTLA-4 isoform lacking exons 2 and 3 causes autoimmunity Journal of Immunology. 188: 155-162. PMID 22124121 DOI: 10.4049/jimmunol.1102042  0.76
2011 Aubert RD, Kamphorst AO, Sarkar S, Vezys V, Ha SJ, Barber DL, Ye L, Sharpe AH, Freeman GJ, Ahmed R. Antigen-specific CD4 T-cell help rescues exhausted CD8 T cells during chronic viral infection. Proceedings of the National Academy of Sciences of the United States of America. 108: 21182-7. PMID 22160724 DOI: 10.1073/pnas.1118450109  0.76
2011 Shainheit MG, Lasocki KW, Finger E, Larkin BM, Smith PM, Sharpe AH, Dinarello CA, Rutitzky LI, Stadecker MJ. The pathogenic Th17 cell response to major schistosome egg antigen is sequentially dependent on IL-23 and IL-1β. Journal of Immunology (Baltimore, Md. : 1950). 187: 5328-35. PMID 22003203 DOI: 10.4049/jimmunol.1101445  0.76
2011 Baban B, Chandler PR, Johnson BA, Huang L, Li M, Sharpe ML, Francisco LM, Sharpe AH, Blazar BR, Munn DH, Mellor AL. Physiologic control of IDO competence in splenic dendritic cells. Journal of Immunology (Baltimore, Md. : 1950). 187: 2329-35. PMID 21813777 DOI: 10.4049/jimmunol.1100276  0.76
2011 Paterson AM, Brown KE, Keir ME, Vanguri VK, Riella LV, Chandraker A, Sayegh MH, Blazar BR, Freeman GJ, Sharpe AH. The programmed Death-1 ligand 1:B7-1 pathway restrains diabetogenic effector T cells in vivo Journal of Immunology. 187: 1097-1105. PMID 21697456 DOI: 10.4049/jimmunol.1003496  0.76
2011 Yang J, Riella LV, Chock S, Liu T, Zhao X, Yuan X, Paterson AM, Watanabe T, Vanguri V, Yagita H, Azuma M, Blazar BR, Freeman GJ, Rodig SJ, Sharpe AH, et al. The novel costimulatory programmed death ligand 1/B7.1 pathway is functional in inhibiting alloimmune responses in vivo Journal of Immunology. 187: 1113-1119. PMID 21697455 DOI: 10.4049/jimmunol.1100056  0.76
2011 Brown DR, Calpe S, Keszei M, Wang N, McArdel S, Terhorst C, Sharpe AH. Cutting edge: an NK cell-independent role for Slamf4 in controlling humoral autoimmunity. Journal of Immunology (Baltimore, Md. : 1950). 187: 21-5. PMID 21622868 DOI: 10.4049/jimmunol.1100510  0.76
2011 Koh AE, Njoroge SW, Feliu M, Cook A, Selig MK, Latchman YE, Sharpe AH, Colvin RB, Paul E. The SLAM family member CD48 (Slamf2) protects lupus-prone mice from autoimmune nephritis Journal of Autoimmunity. 37: 48-57. PMID 21561736 DOI: 10.1016/j.jaut.2011.03.004  0.76
2011 Mfarrej B, Keir M, Dada S, Trikudanathan S, Sayegh MH, Sharpe AH, Guleria I. Anti-CD3 mAb treatment cures PDL1-/-.NOD mice of diabetes but precipitates fatal myocarditis. Clinical Immunology (Orlando, Fla.). 140: 47-53. PMID 21498129 DOI: 10.1016/j.clim.2011.03.011  0.76
2011 Jin Y, Chauhan SK, El Annan J, Annan JE, Sage PT, Sharpe AH, Dana R. A novel function for programmed death ligand-1 regulation of angiogenesis. The American Journal of Pathology. 178: 1922-9. PMID 21435468 DOI: 10.1016/j.ajpath.2010.12.027  0.76
2011 Riella LV, Watanabe T, Sage PT, Yang J, Yeung M, Azzi J, Vanguri V, Chandraker A, Sharpe AH, Sayegh MH, Najafian N. Essential role of PDL1 expression on nonhematopoietic donor cells in acquired tolerance to vascularized cardiac allografts. American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons. 11: 832-40. PMID 21401869 DOI: 10.1111/j.1600-6143.2011.03451.x  0.76
2011 Bu DX, Tarrio M, Maganto-Garcia E, Stavrakis G, Tajima G, Lederer J, Jarolim P, Freeman GJ, Sharpe AH, Lichtman AH. Impairment of the programmed cell death-1 pathway increases atherosclerotic lesion development and inflammation. Arteriosclerosis, Thrombosis, and Vascular Biology. 31: 1100-7. PMID 21393583 DOI: 10.1161/ATVBAHA.111.224709  0.76
2011 Allen SJ, Hamrah P, Gate D, Mott KR, Mantopoulos D, Zheng L, Town T, Jones C, von Andrian UH, Freeman GJ, Sharpe AH, BenMohamed L, Ahmed R, Wechsler SL, Ghiasi H. The role of LAT in increased CD8+ T cell exhaustion in trigeminal ganglia of mice latently infected with herpes simplex virus 1. Journal of Virology. 85: 4184-97. PMID 21307196 DOI: 10.1128/JVI.02290-10  0.76
2011 Keszei M, Latchman YE, Vanguri VK, Brown DR, Detre C, Morra M, Arancibia-Carcamo CV, Arancibia CV, Paul E, Calpe S, Castro W, Wang N, Terhorst C, Sharpe AH. Auto-antibody production and glomerulonephritis in congenic Slamf1-/- and Slamf2-/- [B6.129] but not in Slamf1-/- and Slamf2-/- [BALB/c.129] mice. International Immunology. 23: 149-58. PMID 21278219 DOI: 10.1093/intimm/dxq465  0.76
2011 Joller N, Hafler JP, Brynedal B, Kassam N, Spoerl S, Levin SD, Sharpe AH, Kuchroo VK. Cutting edge: TIGIT has T cell-intrinsic inhibitory functions. Journal of Immunology (Baltimore, Md. : 1950). 186: 1338-42. PMID 21199897 DOI: 10.4049/jimmunol.1003081  0.76
2011 Barber DL, Mayer-Barber KD, Feng CG, Sharpe AH, Sher A. CD4 T cells promote rather than control tuberculosis in the absence of PD-1-mediated inhibition. Journal of Immunology (Baltimore, Md. : 1950). 186: 1598-607. PMID 21172867 DOI: 10.4049/jimmunol.1003304  0.76
2010 Francisco LM, Sage PT, Sharpe AH. The PD-1 pathway in tolerance and autoimmunity. Immunological Reviews. 236: 219-42. PMID 20636820 DOI: 10.1111/j.1600-065X.2010.00923.x  0.76
2010 Zhou Q, Munger ME, Highfill SL, Tolar J, Weigel BJ, Riddle M, Sharpe AH, Vallera DA, Azuma M, Levine BL, June CH, Murphy WJ, Munn DH, Blazar BR. Program death-1 signaling and regulatory T cells collaborate to resist the function of adoptively transferred cytotoxic T lymphocytes in advanced acute myeloid leukemia. Blood. 116: 2484-93. PMID 20570856 DOI: 10.1182/blood-2010-03-275446  0.76
2010 Mueller SN, Vanguri VK, Ha SJ, West EE, Keir ME, Glickman JN, Sharpe AH, Ahmed R. PD-L1 has distinct functions in hematopoietic and nonhematopoietic cells in regulating T cell responses during chronic infection in mice. The Journal of Clinical Investigation. 120: 2508-15. PMID 20551512 DOI: 10.1172/JCI40040  0.76
2010 Good-Jacobson KL, Szumilas CG, Chen L, Sharpe AH, Tomayko MM, Shlomchik MJ. PD-1 regulates germinal center B cell survival and the formation and affinity of long-lived plasma cells. Nature Immunology. 11: 535-42. PMID 20453843 DOI: 10.1038/ni.1877  0.76
2010 Brown KE, Freeman GJ, Wherry EJ, Sharpe AH. Role of PD-1 in regulating acute infections. Current Opinion in Immunology. 22: 397-401. PMID 20427170 DOI: 10.1016/j.coi.2010.03.007  0.76
2010 Paterson AM, Sharpe AH. Taming tissue-specific T cells: CTLA-4 reins in self-reactive T cells Nature Immunology. 11: 109-111. PMID 20084066 DOI: 10.1038/ni0210-109  0.76
2010 El Annan J, Goyal S, Zhang Q, Freeman GJ, Sharpe AH, Dana R. Regulation of T-cell chemotaxis by programmed death-ligand 1 (PD-L1) in dry eye-associated corneal inflammation. Investigative Ophthalmology & Visual Science. 51: 3418-23. PMID 20019373 DOI: 10.1167/iovs.09-3684  0.76
2010 Akbari O, Stock P, Singh AK, Lombardi V, Lee WL, Freeman GJ, Sharpe AH, Umetsu DT, DeKruyff RH. PD-L1 and PD-L2 modulate airway inflammation and iNKT-cell-dependent airway hyperreactivity in opposing directions Mucosal Immunology. 3: 81-91. PMID 19741598 DOI: 10.1038/mi.2009.112  0.76
2009 Francisco LM, Salinas VH, Brown KE, Vanguri VK, Freeman GJ, Kuchroo VK, Sharpe AH. PD-L1 regulates the development, maintenance, and function of induced regulatory T cells. The Journal of Experimental Medicine. 206: 3015-29. PMID 20008522 DOI: 10.1084/jem.20090847  0.76
2009 Araki M, Chung D, Liu S, Rainbow DB, Chamberlain G, Garner V, Hunter KM, Vijayakrishnan L, Peterson LB, Oukka M, Sharpe AH, Sobel R, Kuchroo VK, Wicker LS. Genetic evidence that the differential expression of the ligand-independent isoform of CTLA-4 is the molecular basis of the Idd5.1 type 1 diabetes region in nonobese diabetic mice. Journal of Immunology (Baltimore, Md. : 1950). 183: 5146-57. PMID 19783679 DOI: 10.4049/jimmunol.0802610  0.76
2009 Ruffner MA, Kim SH, Bianco NR, Francisco LM, Sharpe AH, Robbins PD. B7-1/2, but not PD-L1/2 molecules, are required on IL-10-treated tolerogenic DC and DC-derived exosomes for in vivo function. European Journal of Immunology. 39: 3084-90. PMID 19757438 DOI: 10.1002/eji.200939407  0.76
2009 Pot C, Jin H, Awasthi A, Liu SM, Lai CY, Madan R, Sharpe AH, Karp CL, Miaw SC, Ho IC, Kuchroo VK. Cutting edge: IL-27 induces the transcription factor c-Maf, cytokine IL-21, and the costimulatory receptor ICOS that coordinately act together to promote differentiation of IL-10-producing Tr1 cells. Journal of Immunology (Baltimore, Md. : 1950). 183: 797-801. PMID 19570826 DOI: 10.4049/jimmunol.0901233  0.52
2009 Paterson AM, Vanguri VK, Sharpe AH. SnapShot: B7/CD28 Costimulation Cell. 137: 974-974.e1. PMID 19490900 DOI: 10.1016/j.cell.2009.05.015  0.76
2009 Sharpe AH. Mechanisms of costimulation. Immunological Reviews. 229: 5-11. PMID 19426211 DOI: 10.1111/j.1600-065X.2009.00784.x  0.76
2009 Chen L, Sham CW, Chan AM, Francisco LM, Wu Y, Mareninov S, Sharpe AH, Freeman GJ, Yang XJ, Braun J, Gordon LK. Role of the immune modulator programmed cell death-1 during development and apoptosis of mouse retinal ganglion cells. Investigative Ophthalmology & Visual Science. 50: 4941-8. PMID 19420345 DOI: 10.1167/iovs.09-3602  0.76
2009 Chen L, Pai V, Levinson R, Sharpe AH, Freeman GJ, Braun J, Gordon LK. Constitutive neuronal expression of the immune regulator, programmed death 1 (PD-1), identified during experimental autoimmune uveitis. Ocular Immunology and Inflammation. 17: 47-55. PMID 19294574 DOI: 10.1080/09273940802491884  0.76
2009 Verhagen J, Gabrysová L, Minaee S, Sabatos CA, Anderson G, Sharpe AH, Wraith DC. Enhanced selection of FoxP3+ T-regulatory cells protects CTLA-4-deficient mice from CNS autoimmune disease. Proceedings of the National Academy of Sciences of the United States of America. 106: 3306-11. PMID 19218450 DOI: 10.1073/pnas.0803186106  0.76
2009 Reynoso ED, Elpek KG, Francisco L, Bronson R, Bellemare-Pelletier A, Sharpe AH, Freeman GJ, Turley SJ. Intestinal tolerance is converted to autoimmune enteritis upon PD-1 ligand blockade. Journal of Immunology (Baltimore, Md. : 1950). 182: 2102-12. PMID 19201863 DOI: 10.4049/jimmunol.0802769  0.76
2009 Schmidt EM, Wang CJ, Ryan GA, Clough LE, Qureshi OS, Goodall M, Abbas AK, Sharpe AH, Sansom DM, Walker LS. Ctla-4 controls regulatory T cell peripheral homeostasis and is required for suppression of pancreatic islet autoimmunity. Journal of Immunology (Baltimore, Md. : 1950). 182: 274-82. PMID 19109158  0.76
2009 Bauquet AT, Jin H, Paterson AM, Mitsdoerffer M, Ho IC, Sharpe AH, Kuchroo VK. The costimulatory molecule ICOS regulates the expression of c-Maf and IL-21 in the development of follicular T helper cells and TH -17 cells Nature Immunology. 10: 167-175. PMID 19098919 DOI: 10.1038/ni.1690  0.76
2008 Brooks DG, Ha SJ, Elsaesser H, Sharpe AH, Freeman GJ, Oldstone MB. IL-10 and PD-L1 operate through distinct pathways to suppress T-cell activity during persistent viral infection. Proceedings of the National Academy of Sciences of the United States of America. 105: 20428-33. PMID 19075244 DOI: 10.1073/pnas.0811139106  0.76
2008 Gotsman I, Sharpe AH, Lichtman AH. T-cell costimulation and coinhibition in atherosclerosis. Circulation Research. 103: 1220-31. PMID 19028921 DOI: 10.1161/CIRCRESAHA.108.182428  0.76
2008 Lucas JA, Menke J, Rabacal WA, Schoen FJ, Sharpe AH, Kelley VR. Programmed death ligand 1 regulates a critical checkpoint for autoimmune myocarditis and pneumonitis in MRL mice. Journal of Immunology (Baltimore, Md. : 1950). 181: 2513-21. PMID 18684942  0.76
2008 Taylor PA, Ehrhardt MJ, Lees CJ, Panoskaltsis-Mortari A, Krieg AM, Sharpe AH, Murphy WJ, Serody JS, Hemmi H, Akira S, Levy RB, Blazar BR. TLR agonists regulate alloresponses and uncover a critical role for donor APCs in allogeneic bone marrow rejection. Blood. 112: 3508-16. PMID 18614760 DOI: 10.1182/blood-2007-09-113670  0.76
2008 Duan B, Niu H, Xu Z, Sharpe AH, Croker BP, Sobel ES, Morel L. Intrafollicular location of marginal zone/CD1d(hi) B cells is associated with autoimmune pathology in a mouse model of lupus. Laboratory Investigation; a Journal of Technical Methods and Pathology. 88: 1008-20. PMID 18607347 DOI: 10.1038/labinvest.2008.62  0.76
2008 Butte MJ, Peña-Cruz V, Kim MJ, Freeman GJ, Sharpe AH. Interaction of human PD-L1 and B7-1. Molecular Immunology. 45: 3567-72. PMID 18585785 DOI: 10.1016/j.molimm.2008.05.014  0.76
2008 Akbari O, Stock P, Meyer EH, Freeman GJ, Sharpe AH, Umetsu DT, DeKruyff RH. ICOS/ICOSL interaction is required for CD4+ invariant NKT cell function and homeostatic survival. Journal of Immunology (Baltimore, Md. : 1950). 180: 5448-56. PMID 18390727  0.76
2008 Ha SJ, Mueller SN, Wherry EJ, Barber DL, Aubert RD, Sharpe AH, Freeman GJ, Ahmed R. Enhancing therapeutic vaccination by blocking PD-1-mediated inhibitory signals during chronic infection. The Journal of Experimental Medicine. 205: 543-55. PMID 18332181 DOI: 10.1084/jem.20071949  0.76
2008 Keir ME, Butte MJ, Freeman GJ, Sharpe AH. PD-1 and its ligands in tolerance and immunity. Annual Review of Immunology. 26: 677-704. PMID 18173375 DOI: 10.1146/annurev.immunol.26.021607.090331  0.76
2007 Kobayashi N, Karisola P, Peña-Cruz V, Dorfman DM, Jinushi M, Umetsu SE, Butte MJ, Nagumo H, Chernova I, Zhu B, Sharpe AH, Ito S, Dranoff G, Kaplan GG, Casasnovas JM, et al. TIM-1 and TIM-4 glycoproteins bind phosphatidylserine and mediate uptake of apoptotic cells. Immunity. 27: 927-40. PMID 18082433 DOI: 10.1016/j.immuni.2007.11.011  0.76
2007 Menke J, Lucas JA, Zeller GC, Keir ME, Huang XR, Tsuboi N, Mayadas TN, Lan HY, Sharpe AH, Kelley VR. Programmed death 1 ligand (PD-L) 1 and PD-L2 limit autoimmune kidney disease: distinct roles. Journal of Immunology (Baltimore, Md. : 1950). 179: 7466-77. PMID 18025191  0.76
2007 Grabie N, Gotsman I, DaCosta R, Pang H, Stavrakis G, Butte MJ, Keir ME, Freeman GJ, Sharpe AH, Lichtman AH. Endothelial programmed death-1 ligand 1 (PD-L1) regulates CD8+ T-cell mediated injury in the heart. Circulation. 116: 2062-71. PMID 17938288 DOI: 10.1161/CIRCULATIONAHA.107.709360  0.76
2007 Keir ME, Freeman GJ, Sharpe AH. PD-1 regulates self-reactive CD8+ T cell responses to antigen in lymph nodes and tissues. Journal of Immunology (Baltimore, Md. : 1950). 179: 5064-70. PMID 17911591  0.76
2007 Mueller SN, Matloubian M, Clemens DM, Sharpe AH, Freeman GJ, Gangappa S, Larsen CP, Ahmed R. Viral targeting of fibroblastic reticular cells contributes to immunosuppression and persistence during chronic infection. Proceedings of the National Academy of Sciences of the United States of America. 104: 15430-5. PMID 17878315 DOI: 10.1073/pnas.0702579104  0.76
2007 Shen L, Jin Y, Freeman GJ, Sharpe AH, Dana MR. The function of donor versus recipient programmed death-ligand 1 in corneal allograft survival. Journal of Immunology (Baltimore, Md. : 1950). 179: 3672-9. PMID 17785803  0.76
2007 Tai X, Van Laethem F, Sharpe AH, Singer A. Induction of autoimmune disease in CTLA-4-/- mice depends on a specific CD28 motif that is required for in vivo costimulation. Proceedings of the National Academy of Sciences of the United States of America. 104: 13756-61. PMID 17702861 DOI: 10.1073/pnas.0706509104  0.76
2007 Butte MJ, Keir ME, Phamduy TB, Sharpe AH, Freeman GJ. Programmed death-1 ligand 1 interacts specifically with the B7-1 costimulatory molecule to inhibit T cell responses. Immunity. 27: 111-22. PMID 17629517 DOI: 10.1016/j.immuni.2007.05.016  0.76
2007 Kwan KY, Greenwald RJ, Mohanty S, Sharpe AH, Shaw AC, Wang JC. Development of autoimmunity in mice lacking DNA topoisomerase 3β Proceedings of the National Academy of Sciences of the United States of America. 104: 9242-9247. PMID 17517607 DOI: 10.1073/pnas.0703587104  0.76
2007 Keir ME, Francisco LM, Sharpe AH. PD-1 and its ligands in T-cell immunity. Current Opinion in Immunology. 19: 309-14. PMID 17433872 DOI: 10.1016/j.coi.2007.04.012  0.76
2007 Sharpe AH, Wherry EJ, Ahmed R, Freeman GJ. The function of programmed cell death 1 and its ligands in regulating autoimmunity and infection. Nature Immunology. 8: 239-45. PMID 17304234 DOI: 10.1038/ni1443  0.76
2006 Gotsman I, Grabie N, Gupta R, Dacosta R, MacConmara M, Lederer J, Sukhova G, Witztum JL, Sharpe AH, Lichtman AH. Impaired regulatory T-cell response and enhanced atherosclerosis in the absence of inducible costimulatory molecule. Circulation. 114: 2047-55. PMID 17060381 DOI: 10.1161/CIRCULATIONAHA.106.633263  0.76
2006 Freeman GJ, Wherry EJ, Ahmed R, Sharpe AH. Reinvigorating exhausted HIV-specific T cells via PD-1-PD-1 ligand blockade. The Journal of Experimental Medicine. 203: 2223-7. PMID 17000870 DOI: 10.1084/jem.20061800  0.76
2006 Read S, Greenwald R, Izcue A, Robinson N, Mandelbrot D, Francisco L, Sharpe AH, Powrie F. Blockade of CTLA-4 on CD4+CD25+ regulatory T cells abrogates their function in vivo. Journal of Immunology (Baltimore, Md. : 1950). 177: 4376-83. PMID 16982872  0.76
2006 Sharpe AH, Abbas AK. T-cell costimulation--biology, therapeutic potential, and challenges. The New England Journal of Medicine. 355: 973-5. PMID 16908487 DOI: 10.1056/NEJMp068087  0.76
2006 Keir ME, Liang SC, Guleria I, Latchman YE, Qipo A, Albacker LA, Koulmanda M, Freeman GJ, Sayegh MH, Sharpe AH. Tissue expression of PD-L1 mediates peripheral T cell tolerance. The Journal of Experimental Medicine. 203: 883-95. PMID 16606670 DOI: 10.1084/jem.20051776  0.76
2006 Barber DL, Wherry EJ, Masopust D, Zhu B, Allison JP, Sharpe AH, Freeman GJ, Ahmed R. Restoring function in exhausted CD8 T cells during chronic viral infection. Nature. 439: 682-7. PMID 16382236 DOI: 10.1038/nature04444  0.76
2006 Liang SC, Greenwald RJ, Latchman YE, Rosas L, Satoskar A, Freeman GJ, Sharpe AH. PD-L1 and PD-L2 have distinct roles in regulating host immunity to cutaneous leishmaniasis. European Journal of Immunology. 36: 58-64. PMID 16358363 DOI: 10.1002/eji.200535458  0.76
2006 Zeller GC, Hirahashi J, Schwarting A, Sharpe AH, Kelley VR. Inducible co-stimulator null MRL-Faslpr mice: uncoupling of autoantibodies and T cell responses in lupus. Journal of the American Society of Nephrology : Jasn. 17: 122-30. PMID 16291836 DOI: 10.1681/ASN.2005080802  0.76
2005 Keir ME, Latchman YE, Freeman GJ, Sharpe AH. Programmed death-1 (PD-1):PD-ligand 1 interactions inhibit TCR-mediated positive selection of thymocytes. Journal of Immunology (Baltimore, Md. : 1950). 175: 7372-9. PMID 16301644  0.76
2005 Miyamoto K, Kingsley CI, Zhang X, Jabs C, Izikson L, Sobel RA, Weiner HL, Kuchroo VK, Sharpe AH. The ICOS molecule plays a crucial role in the development of mucosal tolerance. Journal of Immunology (Baltimore, Md. : 1950). 175: 7341-7. PMID 16301640  0.76
2005 Ruiz-Perez B, Chung DR, Sharpe AH, Yagita H, Kalka-Moll WM, Sayegh MH, Kasper DL, Tzianabos AO. Modulation of surgical fibrosis by microbial zwitterionic polysaccharides. Proceedings of the National Academy of Sciences of the United States of America. 102: 16753-8. PMID 16275921 DOI: 10.1073/pnas.0505688102  0.76
2005 Li L, Greenwald RJ, Lafuente EM, Tzachanis D, Berezovskaya A, Freeman GJ, Sharpe AH, Boussiotis VA. Rap1-GTP is a negative regulator of Th cell function and promotes the generation of CD4+CD103+ regulatory T cells in vivo. Journal of Immunology (Baltimore, Md. : 1950). 175: 3133-9. PMID 16116203  0.76
2005 Van Berkel MEAT, Schrijver EHR, Hofhuis FMA, Sharpe AH, Coyle AJ, Broeren CP, Tesselaar K, Oosterwegel MA. ICOS contributes to T cell expansion in CTLA-4 deficient mice Journal of Immunology. 175: 182-188. PMID 15972646  0.76
2005 Loser K, Scherer A, Krummen MBW, Varga G, Higuchi T, Schwarz T, Sharpe AH, Grabbe S, Bluestone JA, Beissert S. An important role of CD80/CD86-CTLA-4 signaling during photocarcinogenesis in mice Journal of Immunology. 174: 5298-5305. PMID 15843526  0.76
2005 Keir ME, Sharpe AH. The B7/CD28 costimulatory family in autoimmunity Immunological Reviews. 204: 128-143. PMID 15790355 DOI: 10.1111/j.0105-2896.2005.00242.x  0.76
2005 Greenwald RJ, Freeman GJ, Sharpe AH. The B7 family revisited Annual Review of Immunology. 23: 515-548. PMID 15771580 DOI: 10.1146/annurev.immunol.23.021704.115611  0.76
2005 Abbas AK, Sharpe AH. Dendritic cells giveth and taketh away. Nature Immunology. 6: 227-8. PMID 15716967 DOI: 10.1038/ni0305-227  0.76
2004 Dawicki W, Bertram EM, Sharpe AH, Watts TH. 4-1BB and OX40 act independently to facilitate robust CD8 and CD4 recall responses. Journal of Immunology (Baltimore, Md. : 1950). 173: 5944-51. PMID 15528328  0.76
2004 Kishimoto K, Yuan X, Auchincloss H, Sharpe AH, Mandelbrot DA, Sayegh MH. Mechanism of action of donor-specific transfusion in inducing tolerance: Role of donor MHC molecules, donor co-stimulatory molecules, and indirect antigen presentation Journal of the American Society of Nephrology. 15: 2423-2428. PMID 15339991 DOI: 10.1097/01.ASN.0000137883.20961.2D  0.76
2004 Latchman YE, Liang SC, Wu Y, Chernova T, Sobel RA, Klemm M, Kuchroo VK, Freeman GJ, Sharpe AH. PD-L1-deficient mice show that PD-L1 on T cells, antigen-presenting cells, and host tissues negatively regulates T cells. Proceedings of the National Academy of Sciences of the United States of America. 101: 10691-6. PMID 15249675 DOI: 10.1073/pnas.0307252101  0.76
2004 Buono C, Pang H, Uchida Y, Libby P, Sharpe AH, Lichtman AH. B7-1/B7-2 costimulation regulates plaque antigen-specific T-cell responses and atherogenesis in low-density lipoprotein receptor-deficient mice. Circulation. 109: 2009-15. PMID 15096453 DOI: 10.1161/01.CIR.0000127121.16815.F1  0.76
2004 Taylor PA, Lees CJ, Fournier S, Allison JP, Sharpe AH, Blazar BR. B7 Expression on T Cells Down-Regulates Immune Responses through CTLA-4 Ligation via R-T Interactions Journal of Immunology. 172: 34-39. PMID 14688306  0.76
2003 Rodig N, Ryan T, Allen JA, Pang H, Grabie N, Chernova T, Greenfield EA, Liang SC, Sharpe AH, Lichtman AH, Freeman GJ. Endothelial expression of PD-L1 and PD-L2 down-regulates CD8+ T cell activation and cytolysis. European Journal of Immunology. 33: 3117-26. PMID 14579280 DOI: 10.1002/eji.200324270  0.76
2003 Liang SC, Latchman YE, Buhlmann JE, Tomczak MF, Horwitz BH, Freeman GJ, Sharpe AH. Regulation of PD-1, PD-L1, and PD-L2 expression during normal and autoimmune responses. European Journal of Immunology. 33: 2706-16. PMID 14515254 DOI: 10.1002/eji.200324228  0.76
2003 Ryeom S, Greenwald RJ, Sharpe AH, McKeon F. The threshold pattern of calcineurin-dependent gene expression is altered by loss of the endogenous inhibitor calcipressin. Nature Immunology. 4: 874-81. PMID 12925851 DOI: 10.1038/ni966  0.76
2003 Chang TT, Sobel RA, Wei T, Ransohoff RM, Kuchroo VK, Sharpe AH. Recovery from EAE is associated with decreased survival of encephalitogenic T cells in the CNS of B7-1/B7-2-deficient mice. European Journal of Immunology. 33: 2022-2032. PMID 12884869 DOI: 10.1002/eji.200323180  0.76
2003 Lohr J, Knoechel B, Jiang S, Sharpe AH, Abbas AK. The inhibitory function of B7 costimulators in T cell responses to foreign and self-antigens. Nature Immunology. 4: 664-9. PMID 12766766 DOI: 10.1038/ni939  0.76
2003 Buhlmann JE, Elkin SK, Sharpe AH. A role for the B7-1/B7-2:CD28/CTLA-4 pathway during negative selection Journal of Immunology. 170: 5421-5428. PMID 12759417  0.76
2003 Blazar BR, Sharpe AH, Chen AI, Panoskaltsis-Mortari A, Lees C, Akiba H, Yagita H, Killeen N, Taylor PA. Ligation of OX40 (CD134) regulates graft-versus-host disease (GVHD) and graft rejection in allogeneic bone marrow transplant recipients. Blood. 101: 3741-8. PMID 12521997 DOI: 10.1182/blood-2002-10-3048  0.76
2002 Montagnoli C, Bacci A, Bozza S, Gaziano R, Mosci P, Sharpe AH, Romani L. B7/CD28-dependent CD4+CD25+ regulatory T cells are essential components of the memory-protective immunity to Candida albicans. Journal of Immunology (Baltimore, Md. : 1950). 169: 6298-308. PMID 12444136  0.76
2002 Green KA, Cook WJ, Sharpe AH, Green WR. The CD154/CD40 interaction required for retrovirus-induced murine immunodeficiency syndrome is not mediated by upregulation of the CD80/CD86 costimulatory molecules. Journal of Virology. 76: 13106-10. PMID 12438641 DOI: 10.1128/JVI.76.24.13106-13110.2002  0.76
2002 Prilliman KR, Lemmens EE, Palioungas G, Wolfe TG, Allison JP, Sharpe AH, Schoenberger SP. Cutting edge: A crucial role for B7-CD28 in transmitting T help from APC to CTL Journal of Immunology. 169: 4094-4097. PMID 12370335  0.76
2002 Arestides RS, He H, Westlake RM, Chen AI, Sharpe AH, Perkins DL, Finn PW. Costimulatory molecule OX40L is critical for both Th1 and Th2 responses in allergic inflammation. European Journal of Immunology. 32: 2874-80. PMID 12355440 DOI: 10.1002/1521-4141(2002010)32:10<2874::AID-IMMU2874>3.0.CO;2-4  0.76
2002 Schneider H, Mandelbrot DA, Greenwald RJ, Ng F, Lechler R, Sharpe AH, Rudd CE. Cutting edge: CTLA-4 (CD152) differentially regulates mitogen-activated protein kinases (extracellular signal-regulated kinase and c-Jun N-terminal kinase) in CD4+ T cells from receptor/ligand-deficient mice Journal of Immunology. 169: 3475-3479. PMID 12244135  0.76
2002 Mencacci A, Montagnoli C, Bacci A, Cenci E, Pitzurra L, Spreca A, Kopf M, Sharpe AH, Romani L. CD80+Gr-1+ myeloid cells inhibit development of antifungal Th1 immunity in mice with candidiasis. Journal of Immunology (Baltimore, Md. : 1950). 169: 3180-90. PMID 12218136  0.76
2002 Jabs C, Greve B, Chang TT, Sobel RA, Sharpe AH, Kuchroo VK. Genetic background determines the requirement for B7 costimulation in induction of autoimmunity. European Journal of Immunology. 32: 2687-97. PMID 12207354 DOI: 10.1002/1521-4141(200209)32:9<2687::AID-IMMU2687>3.0.CO;2-1  0.76
2002 Freeman GJ, Sharpe AH, Kuchroo VK. Protect the killer: CTLS need defenses against the tumor Nature Medicine. 8: 787-789. PMID 12152031 DOI: 10.1038/nm0802-787  0.76
2002 Akbari O, Freeman GJ, Meyer EH, Greenfield EA, Chang TT, Sharpe AH, Berry G, DeKruyff RH, Umetsu DT. Antigen-specific regulatory T cells develop via the ICOS-ICOS-ligand pathway and inhibit allergen-induced airway hyperreactivity. Nature Medicine. 8: 1024-32. PMID 12145647 DOI: 10.1038/nm745  0.76
2002 Ekkens MJ, Liu Z, Liu Q, Foster A, Whitmire J, Pesce J, Sharpe AH, Urban JF, Gause WC. Memory Th2 effector cells can develop in the absence of B7-1/B7-2, CD28 interactions, and effector Th cells after priming with an intestinal nematode parasite. Journal of Immunology (Baltimore, Md. : 1950). 168: 6344-51. PMID 12055251  0.76
2002 Greenwald RJ, Latchman YE, Sharpe AH. Negative co-receptors on lymphocytes Current Opinion in Immunology. 14: 391-396. PMID 11973140 DOI: 10.1016/S0952-7915(02)00341-2  0.76
2002 Sharpe AH, Freeman GJ. The B7-CD28 superfamily Nature Reviews Immunology. 2: 116-126. PMID 11910893  0.76
2002 Chang TT, Kuchroo VK, Sharpe AH. Role of the B7-CD28/CTLA-4 pathway in autoimmune disease. Current Directions in Autoimmunity. 5: 113-30. PMID 11826754  0.76
2002 Greenwald RJ, Oosterwegel MA, Van Der Woude D, Kubal A, Mandelbrot DA, Boussiotis VA, Sharpe AH. CTLA-4 regulates cell cycle progression during a primary immune response European Journal of Immunology. 32: 366-373. PMID 11807776 DOI: 10.1002/1521-4141(200202)32:2<366::AID-IMMU366>3.0.CO;2-5  0.76
2002 Greenwald RJ, McAdam AJ, Van der Woude D, Satoskar AR, Sharpe AH. Cutting edge: Inducible costimulator protein regulates both Th1 and Th2 responses to cutaneous Leishmaniasis Journal of Immunology. 168: 991-995. PMID 11801630  0.76
2001 Mandelbrot DA, Kishimoto K, Auchincloss H. J, Sharpe AH, Sayegh MH. Rejection of mouse cardiac allografts by costimulation in trans Journal of Immunology. 167: 1174-1178. PMID 11466331  0.76
2001 Yoshida K, Kuo F, George EL, Sharpe AH, Dutta A. Requirement of CDC45 for postimplantation mouse development Molecular and Cellular Biology. 21: 4598-4603. PMID 11416137 DOI: 10.1128/MCB.21.14.4598-4603.2001  0.76
2001 McAdam AJ, Greenwald RJ, Levin MA, Chernova T, Malenkovich N, Ling V, Freeman GJ, Sharpe AH. ICOS is critical for CD40-mediated antibody class switching. Nature. 409: 102-5. PMID 11343122 DOI: 10.1038/35051107  0.76
2001 Mandelbrot DA, Oosterwegel MA, Shimizu K, Yamada A, Freeman GJ, Mitchell RN, Sayegh MH, Sharpe AH. B7-dependent T-cell costimulation in mice lacking CD28 and CTLA4. The Journal of Clinical Investigation. 107: 881-7. PMID 11285307 DOI: 10.1172/JCI11710  0.76
2001 Greenwald RJ, Boussiotis VA, Lorsbach RB, Abbas AK, Sharpe AH. CTLA-4 regulates induction of anergy in vivo Immunity. 14: 145-155. PMID 11239447  0.76
2000 Santra S, Barouch DH, Jackson SS, Kuroda MJ, Schmitz JE, Lifton MA, Sharpe AH, Letvin NL. Functional equivalency of B7-1 and B7-2 for costimulating plasmid DNA vaccine-elicited CTL responses. Journal of Immunology (Baltimore, Md. : 1950). 165: 6791-5. PMID 11120800  0.76
2000 Gaglia JL, Greenfield EA, Mattoo A, Sharpe AH, Freeman GJ, Kuchroo VK. Intercellular adhesion molecule 1 is critical for activation of CD28-deficient T cells Journal of Immunology. 165: 6091-6098. PMID 11086041  0.76
2000 McAdam AJ, Chang TT, Lumelsky AE, Greenfield EA, Boussiotis VA, Duke-Cohan JS, Chernova T, Malenkovich N, Jabs C, Kuchroo VK, Ling V, Collins M, Sharpe AH, Freeman GJ. Mouse inducible costimulatory molecule (ICOS) expression is enhanced by CD28 costimulation and regulates differentiation of CD4+ T cells. Journal of Immunology (Baltimore, Md. : 1950). 165: 5035-40. PMID 11046032  0.76
2000 Santra S, Barouch DH, Sharpe AH, Letvin NL. B7 co-stimulatory requirements differ for induction of immune responses by DNA, protein and recombinant pox virus vaccination European Journal of Immunology. 30: 2650-2659. PMID 11009099 DOI: 10.1002/1521-4141(200009)30:9<2650::AID-IMMU2650>3.0.CO;2-K  0.76
2000 Liang B, Kashgarian MJ, Sharpe AH, Mamula MJ. Autoantibody responses and pathology regulated by B7-1 and B7-2 costimulation in MRL/lpr lupus Journal of Immunology. 165: 3436-3443. PMID 10975864  0.76
2000 McAdam AJ, Gewurz BE, Farkash EA, Sharpe AH. Either B7 costimulation or IL-2 can elicit generation of primary alloreactive CTL Journal of Immunology. 165: 3088-3093. PMID 10975820  0.76
2000 Furukawa Y, Mandelbrot DA, Libby P, Sharpe AH, Mitchell RN. Association of B7-1 co-stimulation with the development of graft arterial disease. Studies using mice lacking B7-1, B7-2, or B7-1/B7-2. The American Journal of Pathology. 157: 473-84. PMID 10934151 DOI: 10.1016/S0002-9440(10)64559-2  0.76
2000 Kinoshita K, Tesch G, Schwarting A, Maron R, Sharpe AH, Kelley VR. Costimulation by B7-1 and B7-2 is required for autoimmune disease in MRL-Fas(lpr) mice Journal of Immunology. 164: 6046-6056. PMID 10820290  0.76
2000 Szot GL, Zhou P, Sharpe AH, He G, Kim O, Newell KA, Bluestone JA, Thistlethwaite JR. Absence of host B7 expression is sufficient for long-term murine vascularized heart allograft survival. Transplantation. 69: 904-9. PMID 10755548  0.76
2000 Yu X, Fournier S, Allison JP, Sharpe AH, Hodes RJ. The role of B7 costimulation in CD4/CD8 T cell homeostasis Journal of Immunology. 164: 3543-3553. PMID 10725709  0.76
2000 Qian J, Collins M, Sharpe AH, Hoyer LW. Prevention and treatment of factor VIII inhibitors in murine hemophilia A Blood. 95: 1324-1329. PMID 10666206  0.76
2000 Lynch WP, Sharpe AH. Differential glycosylation of the Cas-Br-E Env protein is associated with retrovirus-induced spongiform neurodegeneration Journal of Virology. 74: 1558-1565. PMID 10627570 DOI: 10.1128/JVI.74.3.1558-1565.2000  0.76
2000 McAdam AJ, Farkash EA, Gewurz BE, Sharpe AH. B7 costimulation is critical for antibody class switching and CD8+ cytotoxic T-lymphocyte generation in the host response to vesicular stomatitis virus Journal of Virology. 74: 203-208. PMID 10590107  0.76
1999 Anderson DE, Sharpe AH, Hafler DA. The B7-CD28/CTLA-4 costimulatory pathways in autoimmune disease of the central nervous system. Current Opinion in Immunology. 11: 677-83. PMID 10631554 DOI: 10.1016/S0952-7915(99)00036-9  0.76
1999 Abbas AK, Sharpe AH. T-cell stimulation: An abundance of B7s Nature Medicine. 5: 1345-1346. PMID 10581066 DOI: 10.1038/70905  0.76
1999 Guttormsen HK, Sharpe AH, Chandraker AK, Brigtsen AK, Sayegh MH, Kasper DL. Cognate stimulatory B-cell-T-cell interactions are critical for T-cell help recruited by glycoconjugate vaccines Infection and Immunity. 67: 6375-6384. PMID 10569753  0.76
1999 Schweitzer AN, Sharpe AH. Mutual regulation between B7-1 (CD80) expressed on T cells and IL-4 Journal of Immunology. 163: 4819-4825. PMID 10528182  0.76
1999 Ling V, Wu PW, Finnerty HF, Sharpe AH, Gray GS, Collins M. Complete sequence determination of the mouse and human CTLA4 gene loci: cross-species DNA sequence similarity beyond exon borders. Genomics. 60: 341-55. PMID 10493833 DOI: 10.1006/geno.1999.5930  0.76
1999 Mandelbrot DA, Furukawa Y, McAdam AJ, Alexander SI, Libby P, Mitchell RN, Sharpe AH. Expression of B7 molecules in recipient, not donor, mice determines the survival of cardiac allografts. Journal of Immunology (Baltimore, Md. : 1950). 163: 3753-7. PMID 10490971  0.76
1999 Chang TT, Jabs C, Sobel RA, Kuchroo VK, Sharpe AH. Studies in B7-deficient mice reveal a critical role for B7 costimulation in both induction and effector phases of experimental autoimmune encephalomyelitis. The Journal of Experimental Medicine. 190: 733-40. PMID 10477557 DOI: 10.1084/jem.190.5.733  0.76
1999 Oosterwegel MA, Mandelbrot DA, Boyd SD, Lorsbach RB, Jarrett DY, Abbas AK, Sharpe AH. The role of CTLA-4 in regulating Th2 differentiation. Journal of Immunology (Baltimore, Md. : 1950). 163: 2634-9. PMID 10453003  0.76
1999 Liang B, Gee RJ, Kashgarian MJ, Sharpe AH, Mamula MJ. B7 costimulation in the development of lupus: Autoimmunity arises either in the absence of B7.1/B7.2 or in the presence of anti-B7.1/B7.2 blocking antibodies Journal of Immunology. 163: 2322-2329. PMID 10438978  0.76
1999 Lynch WP, Sharpe AH, Snyder EY. Neural stem cells as engraftable packaging lines can mediate gene delivery to microglia: evidence from studying retroviral env-related neurodegeneration. Journal of Virology. 73: 6841-51. PMID 10400782  0.76
1999 Blazar BR, Taylor PA, Panoskaltsis-Mortari A, Sharpe AH, Vallera DA. Opposing roles of CD28:B7 and CTLA-4:B7 pathways in regulating in vivo alloresponses in murine recipients of MHC disparate T cells Journal of Immunology. 162: 6368-6377. PMID 10352249  0.76
1999 Khattri R, Auger JA, Griffin MD, Sharpe AH, Bluestone JA. Lymphoproliferative disorder in CTLA-4 knockout mice is characterized by CD28-regulated activation of Th2 responses Journal of Immunology. 162: 5784-5791. PMID 10229811  0.76
1999 La Motte RN, Sharpe AH, Bluestone JA, Mokyr MB. Host B7-1 and B7-2 costimulatory molecules contribute to the eradication of B7-1-transfected P815 tumor cells via a CD8+ T cell-dependent mechanism. Journal of Immunology (Baltimore, Md. : 1950). 162: 4817-23. PMID 10202025  0.76
1999 Hernandez HJ, Sharpe AH, Stadecker MJ. Experimental murine schistosomiasis in the absence of B7 costimulatory molecules: Reversal of elicited T cell cytokine profile and partial inhibition of egg granuloma formation Journal of Immunology. 162: 2884-2889. PMID 10072537  0.76
1999 Judge TA, Wu Z, Zheng XG, Sharpe AH, Sayegh MH, Turka LA. The role of CD80, CD86, and CTLA4 in alloimmune responses and the induction of long-term allograft survival Journal of Immunology. 162: 1947-1951. PMID 9973463  0.76
1999 González-Cabrero J, Wise CJ, Latchman Y, Freeman GJ, Sharpe AH, Reiser H. CD48-deficient mice have a pronounced defect in CD4+ T cell activation Proceedings of the National Academy of Sciences of the United States of America. 96: 1019-1023. PMID 9927686 DOI: 10.1073/pnas.96.3.1019  0.76
1999 Mandelbrot DA, McAdam AJ, Sharpe AH. B7-1 or B7-2 is required to produce the lymphoproliferative phenotype in mice lacking cytotoxic T lymphocyte-associated antigen 4 (CTLA-4) Journal of Experimental Medicine. 189: 435-440. PMID 9892625 DOI: 10.1084/jem.189.2.435  0.76
1998 La Motte RN, Sharpe AH, Bluestone JA, Mokyr MB. Importance of B7-1-expressing host antigen-presenting cells for the eradication of B7-2 transfected P815 tumor cells. Journal of Immunology (Baltimore, Md. : 1950). 161: 6552-8. PMID 9862681  0.76
1998 Rauschmayr-Kopp T, Williams IR, Borriello F, Sharpe AH, Kupper TS. Distinct roles for B7 costimulation in contact hypersensitivity and humoral immune responses to epicutaneous antigen European Journal of Immunology. 28: 4221-4227. PMID 9862359  0.76
1998 McAdam AJ, Schweitzer AN, Sharpe AH. The role of B7 co-stimulation in activation and differentiation of CD4+ and CD8+ T cells Immunological Reviews. 165: 231-247. PMID 9850864  0.76
1998 Schweitzer AN, Sharpe AH. Studies using antigen-presenting cells lacking expression of both B7-1 (CD80) and B7-2 (CD86) show distinct requirements for B7 molecules during priming versus restimulation of Th2 but not Th1 cytokine production Journal of Immunology. 161: 2762-2771. PMID 9743334  0.76
1998 Guttormsen HK, Sayegh MH, Sharpe AH, Wetzler LM, Chandraker AK, Kasper DL. Recruitment of T cell help by a glyco-conjugate vaccine Faseb Journal. 12.  0.76
1997 Van Parijs L, Sethna MP, Schweitzer AN, Borriello F, Sharpe AH, Abbas AK. Functional Consequences of Dysregulated B7-1 (CD80) and B7-2 (CD86) Expression in B or T Lymphocytes of Transgenic Mice Journal of Immunology. 159: 5336-5344. PMID 9548473  0.76
1997 Schweitzer AN, Sharpe AH. The complexity of the B7-CD28/CTLA-4 costimulatory pathway Agents and Actions Supplements. 49: 33-43. PMID 9426826  0.76
1997 Reeves RH, Patch D, Sharpe AH, Borriello F, Freeman GJ, Edelhoff S, Disteche C. The costimulatory genes Cd80 and Cd86 are linked on mouse chromosome 16 and human chromosome 3 Mammalian Genome. 8: 581-582. PMID 9250865 DOI: 10.1007/s003359900508  0.76
1997 Tivol EA, Boyd SD, McKeon S, Borriello F, Nickerson P, Strom TB, Sharpe AH. CTLA4Ig prevents lymphoproliferation and fatal multiorgan tissue destruction in CTLA-4-deficient mice. Journal of Immunology (Baltimore, Md. : 1950). 158: 5091-4. PMID 9164923  0.76
1997 Borriello F, Lederer J, Scott S, Sharpe AH. MRC OX-2 Defines a Novel T Cell Costimulatory Pathway Journal of Immunology. 158: 4548-4554. PMID 9144466  0.76
1997 Schweitzer AN, Borriello F, Wong RCK, Abbas AK, Sharpe AH. Role of Costimulators in T Cell Differentiation: Studies Using Antigen-Presenting Cells Lacking Expression of CD80 or CD86 Journal of Immunology. 158: 2713-2722. PMID 9058805  0.76
1996 Tivol EA, Schweitzert AN, Sharpe AH. Costimulation and autoimmunity Current Opinion in Immunology. 8: 822-830. PMID 8994862 DOI: 10.1016/S0952-7915(96)80011-2  0.76
1996 Coxon A, Rieu P, Barkalow FJ, Askari S, Sharpe AH, Von Andrian UH, Arnaout MA, Mayadas TN. A novel role for the β2 integrin CD11b/CD18 in neutrophil apoptosis: A homeostatic mechanism in inflammation Immunity. 5: 653-666. PMID 8986723 DOI: 10.1016/S1074-7613(00)80278-2  0.76
1996 Wang JH, Nichogiannopoulou A, Wu L, Sun L, Sharpe AH, Bigby M, Georgopoulos K. Selective defects in the development of the fetal and adult lymphoid system in mice with an Ikaros null mutation Immunity. 5: 537-549. PMID 8986714 DOI: 10.1016/S1074-7613(00)80269-1  0.76
1996 Lynch WP, Snyder EY, Qualtiere L, Portis JL, Sharpe AH. Late virus replication events in microglia are required for neurovirulent retrovirus-induced spongiform neurodegeneration: evidence from neural progenitor-derived chimeric mouse brains. Journal of Virology. 70: 8896-907. PMID 8971019  0.76
1996 Blazar BR, Sharpe AH, Taylor PA, Panoskaltsis-Mortari A, Gray GS, Korngold R, Vallera DA. Infusion of Anti-B7.1 (CD80) and Anti-B7.2 (CD86) Monoclonal Antibodies Inhibits Murine Graft-Versus-Host Disease Lethality in Part Via Direct Effects on CD4+ and CD8+ T Cells Journal of Immunology. 157: 3250-3259. PMID 8871619  0.76
1996 Wang Q, Stacy T, Binder M, Marín-Padilla M, Sharpe AH, Speck NA. Disruption of the Cbfa2 gene causes necrosis and hemorrhaging in the central nervous system and blocks definitive hematopoiesis Proceedings of the National Academy of Sciences of the United States of America. 93: 3444-3449. PMID 8622955 DOI: 10.1073/pnas.93.8.3444  0.76
1996 Sharpe AH. Costimulatory signals and viral immunity Seminars in Virology. 7: 103-111. DOI: 10.1006/smvy.1996.0013  0.76
1995 Parkins AC, Sharpe AH, Orkin SH. Lethal β-thalassaemia in mice lacking the erythroid CACCC-transcription factor EKLF Nature. 375: 318-322. PMID 7753195  0.76
1995 Johnson KA, Lerner CP, Di Lacio LC, Laird PW, Sharpe AH, Simpson EM. Transgenic mice for the preparation of hygromycin-resistant primary embryonic fibroblast feeder layers for embryonic stem cell selections Nucleic Acids Research. 23: 1273-1275. PMID 7739908 DOI: 10.1093/nar/23.7.1273  0.76
1995 Witke W, Sharpe AH, Hartwig JH, Azuma T, Stossel TP, Kwiatkowski DJ. Hemostatic, inflammatory, and fibroblast responses are blunted in mice lacking gelsolin Cell. 81: 41-51. PMID 7720072 DOI: 10.1016/0092-8674(95)90369-0  0.76
1995 Tivol EA, Borriello F, Schweitzer AN, Lynch WP, Bluestone JA, Sharpe AH. Loss of CTLA-4 leads to massive lymphoproliferation and fatal multiorgan tissue destruction, revealing a critical negative regulatory role of CTLA-4 Immunity. 3: 541-547. PMID 7584144 DOI: 10.1016/1074-7613(95)90125-6  0.76
1995 Sharpe AH. Analysis of lymphocyte costimulation in vivo using transgenic and 'knockout' mice Current Opinion in Immunology. 7: 389-395. PMID 7546405 DOI: 10.1016/0952-7915(95)80115-4  0.76
1995 Jellis CL, Wang SS, Rennert P, Borriello F, Sharpe AH, Green NR, Gray GS. Genomic organization of the gene coding for the costimulatory human B-lymphocyte antigen B7-2 (CD86) Immunogenetics. 42: 85-89. PMID 7541777 DOI: 10.1007/BF00178582  0.76
1995 Prabhu Das MR, Zamvil SS, Borriello F, Weiner HL, Sharpe AH, Kuchroo VK. Reciprocal expression of co-stimulatory molecules, B7-1 and B7-2, on murine T cells following activation European Journal of Immunology. 25: 207-211. PMID 7531145 DOI: 10.1002/eji.1830250134  0.76
1995 Borriello F, Oliveros J, Freeman GJ, Nadler LM, Sharpe AH. Differential expression of alternate mB7-2 transcripts Journal of Immunology. 155: 5490-5497. PMID 7499829  0.76
1995 Thomis DC, Gurniak CB, Tivol E, Sharpe AH, Berg LJ. Defects in B lymphocyte maturation and T lymphocyte activation in mice lacking Jak3 Science. 270: 794-797. PMID 7481767  0.76
1994 Sethna MP, van Perijs L, Sharpe AH, Abbas AK, Freemant GJ. A negative regulatory function of B7 revealed in B7-1 transgenic mice Immunity. 1: 415-421. PMID 7533646 DOI: 10.1016/1074-7613(94)90072-8  0.76
1994 Borriello F, Freeman GJ, Edelhoff S, Disteche CM, Nadler LM, Sharpe AH. Characterization of the murine B7-1 genomic locus reveals an additional exon encoding an alternative cytoplasmic domain and a chromosomal location of chromosome 16, band B5 Journal of Immunology. 153: 5038-5048. PMID 7525722  0.76
1993 Sharpe AH, Jaenisch R. Retroviral spongiform degenerative disease produced by the murine neurotropic retrovirus Cas-Br-E Developments in Biological Standardization. 80: 45-52. PMID 8270115  0.76
1992 Lee KF, Li E, Huber LJ, Landis SC, Sharpe AH, Chao MV, Jaenisch R. Targeted mutation of the gene encoding the low affinity NGF receptor p75 leads to deficits in the peripheral sensory nervous system. Cell. 69: 737-49. PMID 1317267 DOI: 10.1016/0092-8674(92)90286-L  0.76
1990 Ruprecht RM, Sharpe AH, Jaenisch R, Trites D. Analysis of 3'-azido-3'-deoxythymidine levels in tissues and milk by isocratic high-performance liquid chromatography. Journal of Chromatography. 528: 371-83. PMID 2384575 DOI: 10.1016/S0378-4347(00)82395-6  0.76
1990 Sharpe AH, Hunter JJ, Chassler P, Jaenisch R. Role of abortive retroviral infection of neurons in spongiform CNS degeneration Nature. 346: 181-183. PMID 2195355  0.76
1990 Sugimoto M, Sharpe AH, Sato Y, Greene MI, Fields BN. Reovirus transport – studies using lymphocytosis promoting factor Pathobiology. 58: 185-192. PMID 2174674 DOI: 10.1159/000163582  0.76
1990 Weiher H, Noda T, Gray DA, Sharpe AH, Jaenisch R. Transgenic mouse model of kidney disease: Insertional inactivation of ubiquitously expressed gene leads to nephrotic syndrome Cell. 62: 425-434. PMID 1696177 DOI: 10.1016/0092-8674(90)90008-3  0.76
1989 Sharpe AH, Hunter JJ, Ruprecht RM, Jaenisch R. Maternal transmission of retroviral disease and strategies for preventing infection of the neonate Journal of Virology. 63: 1049-1053. PMID 2915376  0.76
1989 Compere SJ, Baldacci P, Sharpe AH, Thompson T, Land H, Jaenisch R. The ras and myc oncogenes cooperate in tumor induction in many tissues when introduced into midgestation mouse embryos by retroviral vectors Proceedings of the National Academy of Sciences of the United States of America. 86: 2224-2228. PMID 2648394  0.76
1989 Compere SJ, Baldacci PA, Sharpe AH, Jaenisch R. Retroviral transduction of the human c-Ha-ras-1 oncogene into midgestation mouse embryos promotes rapid epithelial hyperplasia Molecular and Cellular Biology. 9: 6-14. PMID 2648134  0.76
1988 Sharpe AH, Hunter JJ, Ruprecht RM, Jaenisch R. Maternal transmission of retroviral disease: Transgenic mice as a rapid test system for evaluating potential and transplacental antiretroviral therapy Proceedings of the National Academy of Sciences of the United States of America. 85: 9792-9796. PMID 2849117  0.76
1987 Sharpe AH, Jaenisch R, Ruprecht RM. Retroviruses and mouse embryos: A rapid model for neurovirulence and transplacental antiviral therapy Science. 236: 1671-1674. PMID 3037694  0.76
1987 Wolf JL, Dambrauskas R, Sharpe AH, Trier JS. Adherence to and penetration of the intestinal epithelium by reovirus type 1 in neonatal mice Gastroenterology. 92: 82-91. PMID 3023169  0.76
1986 Gaulton GN, Sharpe AH, Chang DW, Fields BN, Greene MI. Syngeneic monoclonal internal image anti-idiotopes as prophylactic vaccines Journal of Immunology. 137: 2930-2936. PMID 3020129  0.76
1985 Sharpe AH, Fields BN. Pathogenesis of viral infections. Basic concepts derived from the reovirus model New England Journal of Medicine. 312: 486-496. PMID 2982096  0.76
1985 Sharpe AH, Gaulton GN, Ertl HCJ, Finberg RW, McDade KK, Fields BN, Greene MI. Cell receptors for the mammalian reovirus. IV. Reovirus-specific cytolytic T cell lines that have idiotypic receptors recognize anti-idiotypic B cell hybridomas Journal of Immunology. 134: 2702-2706. PMID 2579153  0.76
1984 Sharpe AH, Gaulton GN, McDade KK, Fields BN, Greene MI. Syngeneic monoclonal antiidiotype can induce cellular immunity to reovirus Journal of Experimental Medicine. 160: 1195-1205. PMID 6332875  0.76
1982 Sharpe AH, Chen LB, Fields BN. The interaction of mammalian reoviruses with the cytoskeleton of monkey kidney CV-1 cells Virology. 120: 399-411. PMID 7201720 DOI: 10.1016/0042-6822(82)90040-X  0.76
1982 Sharpe AH, Fields BN. Reovirus inhibition of cellular RNA and protein synthesis: Role of the S4 gene Virology. 122: 381-391. PMID 6183822 DOI: 10.1016/0042-6822(82)90237-9  0.76
1981 Ahmed R, Canning WM, Kauffman RS, Sharpe AH, Hallum JV, Fields BN. Role of the host cell in persistent viral infection: Coevolution of L cells and reovirus during persistent infection Cell. 25: 325-332. PMID 7285112 DOI: 10.1016/0092-8674(81)90050-7  0.76
1981 Sharpe AH, Fields BN. Reovirus inhibition of cellular DNA synthesis: role of the S1 gene Journal of Virology. 38: 389-392. PMID 7241660  0.76
1981 Wolf JL, Rubin DH, Finberg R, Kauffman RS, Sharpe AH, Trier JS, Fields BN. Intestinal M cells: A pathway for entry of reovirus into the host Science. 212: 471-472. PMID 6259737 DOI: 10.1126/science.6259737  0.76
1980 Fields BN, Weiner HL, Drayna DT, Sharpe AH. The role of the reovirus hemagglutinin in viral virulence Annals of the New York Academy of Sciences. 125-134. PMID 7013619  0.76
1980 Sharpe AH, Chen LB, Murphy JR, Fields BN. Specific disruption of vimentin filament organization in monkey kidney CV-1 cells by diphtheria toxin, exotoxin A, and cycloheximide Proceedings of the National Academy of Sciences of the United States of America. 77: 7267-7271. PMID 6784120  0.76
1978 Mustoe TA, Ramig RF, Sharpe AH, Fields BN. Genetics of reovirus: Identification of the ds RNA segments encoding the polypeptides of the μ and σ size classes Virology. 89: 594-604. PMID 716219 DOI: 10.1016/0042-6822(78)90200-3  0.76
1978 Mustoe TA, Ramig RF, Sharpe AH, Fields BN. A genetic map of reovirus II. Assignment of the double-stranded RNA-positive mutant groups A, B, and G to genome segments Virology. 85: 545-556. PMID 664215 DOI: 10.1016/0042-6822(78)90460-9  0.76
1978 Ramig RF, Mustoe TA, Sharpe AH, Fields BN. A genetic map of reovirus II. Assignment of the double-stranded RNA-negative mutant groups C, D, and E to genome segments Virology. 85: 531-544. PMID 664214 DOI: 10.1016/0042-6822(78)90459-2  0.76
1978 Sharpe AH, Ramig RF, Mustoe TA, Fields BN. A genetic map of reovirus I. Correlation of genome RNAs between serotypes 1, 2, and 3 Virology. 84: 63-74. PMID 619493 DOI: 10.1016/0042-6822(78)90218-0  0.76
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