Derya Unutmaz - Publications

Affiliations: 
Vanderbilt University, Nashville, TN 
Area:
Immunology, Microbiology Biology

124 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2022 Dogan M, Karhan E, Kozhaya L, Placek L, Chen X, Yigit M, Unutmaz D. Engineering Human MAIT Cells with Chimeric Antigen Receptors for Cancer Immunotherapy. Journal of Immunology (Baltimore, Md. : 1950). PMID 36165183 DOI: 10.4049/jimmunol.2100856  0.516
2022 Dey M, Kim MH, Nagamine MT, Karhan E, Kozhaya L, Dogan M, Unutmaz D, Ozbolat IT. Biofabrication of 3D Breast cancer models for dissecting the cytotoxic response of human T cells expressing engineered MAIT cell receptors. Biofabrication. PMID 36108605 DOI: 10.1088/1758-5090/ac925a  0.39
2022 Zhang S, Cooper-Knock J, Weimer AK, Shi M, Kozhaya L, Unutmaz D, Harvey C, Julian TH, Furini S, Frullanti E, Fava F, Renieri A, Gao P, Shen X, Timpanaro IS, et al. Multiomic analysis reveals cell-type-specific molecular determinants of COVID-19 severity. Cell Systems. PMID 35690068 DOI: 10.1016/j.cels.2022.05.007  0.369
2022 Unutmaz D. CCR5: The Receptor That Unlocks the Door for HIV Entry into Cells. Journal of Immunology (Baltimore, Md. : 1950). 208: 2459-2460. PMID 35595303 DOI: 10.4049/jimmunol.2200108  0.373
2021 Tailor J, Foldi J, Generoso M, McCarty B, Alankar A, Kilberg M, Mwamzuka M, Marshed F, Ahmed A, Liu M, Borkowsky W, Unutmaz D, Khaitan A. Disease Progression in Children with Perinatal HIV Correlates with Increased PD-1+ CD8 T Cells that Coexpress Multiple Immune Checkpoints. The Journal of Infectious Diseases. PMID 33864071 DOI: 10.1093/infdis/jiab204  0.433
2020 Saka D, Gökalp M, Piyade B, Cevik NC, Arik Sever E, Unutmaz D, Ceyhan GO, Demir IE, Asimgil H. Mechanisms of T-Cell Exhaustion in Pancreatic Cancer. Cancers. 12. PMID 32823814 DOI: 10.3390/cancers12082274  0.491
2020 Kahlfuss S, Kaufmann U, Concepcion AR, Noyer L, Raphael D, Vaeth M, Yang J, Pancholi P, Maus M, Muller J, Kozhaya L, Khodadadi-Jamayran A, Sun Z, Shaw P, Unutmaz D, et al. STIM1-mediated calcium influx controls antifungal immunity and the metabolic function of non-pathogenic Th17 cells. Embo Molecular Medicine. e11592. PMID 32609955 DOI: 10.15252/Emmm.201911592  0.505
2020 Nasrallah R, Imianowski CJ, Bossini-Castillo L, Grant FM, Dogan M, Placek L, Kozhaya L, Kuo P, Sadiyah F, Whiteside SK, Mumbach MR, Glinos D, Vardaka P, Whyte CE, Lozano T, ... ... Unutmaz D, et al. A distal enhancer at risk locus 11q13.5 promotes suppression of colitis by T cells. Nature. PMID 32499651 DOI: 10.1038/S41586-020-2296-7  0.498
2020 Liu J, Kozhaya L, Torres VJ, Unutmaz D, Lu M. Structure-based discovery of a small-molecule inhibitor of methicillin-resistant virulence. The Journal of Biological Chemistry. PMID 32179646 DOI: 10.1074/Jbc.Ra120.012697  0.342
2020 Keller MD, Ching KL, Liang FX, Dhabaria A, Tam K, Ueberheide BM, Unutmaz D, Torres VJ, Cadwell K. Decoy exosomes provide protection against bacterial toxins. Nature. PMID 32132711 DOI: 10.1038/S41586-020-2066-6  0.353
2019 Oh J, Unutmaz D. Immune cells for microbiota surveillance. Science (New York, N.Y.). 366: 419-420. PMID 31649181 DOI: 10.1126/science.aaz4014  0.311
2019 Sezen B, Koca S, Alan O, Renzullo S, Ozdemir F, Kozhaya L, Telli T, Karhan E, Ugurlu U, Gulluoglu B, Dane F, Yumuk F, Unutmaz D. Abstract P4-06-29: Prospective immune-profiling of locally advanced and metastatic breast cancer patients Cancer Research. 79. DOI: 10.1158/1538-7445.Sabcs18-P4-06-29  0.319
2018 Shimada K, Porritt RA, Markman JL, O'Rourke JG, Wakita D, Noval Rivas M, Ogawa C, Kozhaya L, Martins GA, Unutmaz D, Baloh RH, Crother TR, Chen S, Arditi M. T Cell-Intrinsic Receptor Interacting Protein 2 Regulates Pathogenic T Helper 17 Cell Differentiation. Immunity. PMID 30366765 DOI: 10.1016/J.Immuni.2018.08.022  0.611
2018 McCarty B, Mwamzuka M, Marshed F, Generoso M, Alvarez P, Ilmet T, Kravietz A, Ahmed A, Borkowsky W, Unutmaz D, Khaitan A. Low Peripheral T Follicular Helper Cells in Perinatally HIV-Infected Children Correlate With Advancing HIV Disease. Frontiers in Immunology. 9: 1901. PMID 30197641 DOI: 10.3389/Fimmu.2018.01901  0.564
2018 Tastan C, Karhan E, Zhou W, Fleming E, Voigt AY, Yao X, Wang L, Horne M, Placek L, Kozhaya L, Oh J, Unutmaz D. Tuning of human MAIT cell activation by commensal bacteria species and MR1-dependent T-cell presentation. Mucosal Immunology. PMID 30115998 DOI: 10.1038/S41385-018-0072-X  0.543
2018 Vermeersch E, Liénart S, Collignon A, Lucas S, Gallimore A, Gysemans C, Unutmaz D, Vanhoorelbeke K, De Meyer SF, Maes W, Deckmyn H. Deletion of GARP on mouse regulatory T cells is not sufficient to inhibit the growth of transplanted tumors. Cellular Immunology. PMID 30093071 DOI: 10.1016/J.Cellimm.2018.07.011  0.453
2018 Chen X, Kozhaya L, Tastan C, Placek L, Dogan M, Horne M, Abblett R, Karhan E, Vaeth M, Feske S, Unutmaz D. Functional Interrogation of Primary Human T Cells via CRISPR Genetic Editing. Journal of Immunology (Baltimore, Md. : 1950). PMID 30021769 DOI: 10.4049/Jimmunol.1701616  0.558
2017 Kwa M, Li X, Novik Y, Oratz R, Jhaveri K, Wu J, Gu P, Meyers M, Muggia F, Speyer J, Iwano A, Bonakdar M, Kozhaya L, Tavukcuoglu E, Budan B, ... ... Unutmaz D, et al. Serial immunological parameters in a phase II trial of exemestane and low-dose oral cyclophosphamide in advanced hormone receptor-positive breast cancer. Breast Cancer Research and Treatment. PMID 29124456 DOI: 10.1007/S10549-017-4570-4  0.337
2017 Foldi J, Kozhaya L, McCarty B, Mwamzuka M, Marshed F, Ilmet T, Kilberg M, Kravietz A, Ahmed A, Borkowsky W, Unutmaz D, Khaitan A. HIV-Infected Children Have Elevated Levels of PD-1+ Memory CD4 T Cells With Low Proliferative Capacity and High Inflammatory Cytokine Effector Functions. The Journal of Infectious Diseases. 216: 641-650. PMID 28934428 DOI: 10.1093/Infdis/Jix341  0.586
2016 Limgala RP, Ioanou C, Plassmeyer M, Ryherd M, Kozhaya L, Austin L, Abidoglu C, Unutmaz D, Alpan O, Goker-Alpan O. Time of Initiating Enzyme Replacement Therapy Affects Immune Abnormalities and Disease Severity in Patients with Gaucher Disease. Plos One. 11: e0168135. PMID 27942037 DOI: 10.1371/Journal.Pone.0168135  0.479
2016 Khaitan A, Kilberg M, Kravietz A, Ilmet T, Tastan C, Mwamzuka M, Marshed F, Liu M, Ahmed A, Borkowsky W, Unutmaz D. HIV-Infected Children Have Lower Frequencies of CD8+ Mucosal-Associated Invariant T (MAIT) Cells that Correlate with Innate, Th17 and Th22 Cell Subsets. Plos One. 11: e0161786. PMID 27560150 DOI: 10.1371/Journal.Pone.0161786  0.613
2016 Vaeth M, Eckstein M, Shaw PJ, Kozhaya L, Yang J, Berberich-Siebelt F, Clancy R, Unutmaz D, Feske S. Store-Operated Ca(2+) Entry in Follicular T Cells Controls Humoral Immune Responses and Autoimmunity. Immunity. PMID 27261277 DOI: 10.1016/J.Immuni.2016.04.013  0.551
2016 Khaitan A, Kravietz A, Mwamzuka M, Marshed F, Ilmet T, Said S, Ahmed A, Borkowsky W, Unutmaz D. FOXP3+Helios+ regulatory T cells, immune activation and advancing disease in HIV infected children. Journal of Acquired Immune Deficiency Syndromes (1999). PMID 27003495 DOI: 10.1097/Qai.0000000000001000  0.577
2016 Diefenbach C, Raphael BG, Grossbard ML, Hymes KB, Moskovits T, Kaminetzky D, Martin P, Ruan J, McShea M, B'etou L, Bonakdar M, Abidoglu C, Kozhaya L, Leonard JP, Unutmaz D. Hodgkin Lymphoma Patients Demonstrate Evidence of Systemic Perturbation of the Monocyte-Dendritic Cell Axis Blood. 128: 2949-2949. DOI: 10.1182/Blood.V128.22.2949.2949  0.444
2016 Kwa M, Novik Y, Oratz R, Jhaveri K, Wu J, Gu P, Meyers M, Muggia F, Bonakdar M, Abidoglu C, Kozhaya L, Li X, Joseph B, Iwano A, Friedman K, ... ... Unutmaz D, et al. Abstract P2-11-11: Phase II trial of exemestane with immunomodulatory oral cyclophosphamide in metastatic hormone receptor (HR)-positive breast cancer: Prolonged progression-free survival (PFS) in patients with distinct T regulatory cell (Treg) profile Cancer Research. 76. DOI: 10.1158/1538-7445.Sabcs15-P2-11-11  0.385
2016 Diefenbach CS, Raphael B, Hymes K, Grossbard M, Moskovits T, Kaminetzky D, Mcshea M, Martin P, Ruan J, Kozhaya L, Bonakdar M, Abidoglu C, Leonard J, Unutmaz D. Abstract 4895: Hodgkin lymphoma patients demonstrate evidence of chronic activation/exhaustion in circulating T cell subsets Cancer Research. 76: 4895-4895. DOI: 10.1158/1538-7445.Am2016-4895  0.506
2015 Kaufmann U, Shaw PJ, Kozhaya L, Subramanian R, Gaida K, Unutmaz D, McBride HJ, Feske S. Selective ORAI1 Inhibition Ameliorates Autoimmune Central Nervous System Inflammation by Suppressing Effector but Not Regulatory T Cell Function. Journal of Immunology (Baltimore, Md. : 1950). PMID 26673135 DOI: 10.4049/Jimmunol.1501406  0.577
2015 Vaeth M, Zee I, Concepcion AR, Maus M, Shaw P, Portal-Celhay C, Zahra A, Kozhaya L, Weidinger C, Philips J, Unutmaz D, Feske S. Ca2+ Signaling but Not Store-Operated Ca2+ Entry Is Required for the Function of Macrophages and Dendritic Cells. Journal of Immunology (Baltimore, Md. : 1950). 195: 1202-17. PMID 26109647 DOI: 10.4049/Jimmunol.1403013  0.457
2015 VanCompernolle S, Smith PB, Bowie JH, Tyler MJ, Unutmaz D, Rollins-Smith LA. Inhibition of HIV infection by caerin 1 antimicrobial peptides. Peptides. PMID 26026377 DOI: 10.1016/J.Peptides.2015.05.004  0.505
2015 Rawlings SA, Alonzo F, Kozhaya L, Torres VJ, Unutmaz D. Elimination of HIV-1-Infected Primary T Cell Reservoirs in an In Vitro Model of Latency. Plos One. 10: e0126917. PMID 25993666 DOI: 10.1371/Journal.Pone.0126917  0.614
2015 Desvignes L, Weidinger C, Shaw P, Vaeth M, Ribierre T, Liu M, Fergus T, Kozhaya L, McVoy L, Unutmaz D, Ernst JD, Feske S. STIM1 controls T cell-mediated immune regulation and inflammation in chronic infection. The Journal of Clinical Investigation. 125: 2347-62. PMID 25938788 DOI: 10.1172/Jci80273  0.571
2014 Mercer F, Khaitan A, Kozhaya L, Aberg JA, Unutmaz D. Differentiation of IL-17-producing effector and regulatory human T cells from lineage-committed naive precursors. Journal of Immunology (Baltimore, Md. : 1950). 193: 1047-54. PMID 24958901 DOI: 10.4049/Jimmunol.1302936  0.52
2014 Ramesh R, Kozhaya L, McKevitt K, Djuretic IM, Carlson TJ, Quintero MA, McCauley JL, Abreu MT, Unutmaz D, Sundrud MS. Pro-inflammatory human Th17 cells selectively express P-glycoprotein and are refractory to glucocorticoids. The Journal of Experimental Medicine. 211: 89-104. PMID 24395888 DOI: 10.1084/Jem.20130301  0.752
2014 Diefenbach CS, Raphael BG, Hymes KB, Moskovits T, Kaminetzky D, Martin P, Ruan J, Lauro S, Banks D, Brown K, Bonakdar M, Abidoglu C, Kozhaya L, Leonard JP, Unutmaz D. Circulating Memory T Cells Isolated from Hodgkin Lymphoma Patients Display Evidence of Exhaustion and Chronic Activation Blood. 124: 4400-4400. DOI: 10.1182/Blood.V124.21.4400.4400  0.514
2014 Dave UP, Palma N, Wang K, Reddy NM, Ali S, Tripathi R, Greenplate A, Irish JM, Unutmaz D, Stephens PJ, Miller VA. Comprehensive Hybrid Capture-Based Genomic Profiling of T-Cell Leukemias and Lymphomas Reveals Targetable JAK1 and JAK3 Co-Existing Mutations Blood. 124: 1672-1672. DOI: 10.1182/Blood.V124.21.1672.1672  0.475
2013 Zhou AX, El Hed A, Mercer F, Kozhaya L, Unutmaz D. The metalloprotease ADAM12 regulates the effector function of human Th17 cells. Plos One. 8: e81146. PMID 24363794 DOI: 10.1371/Journal.Pone.0081146  0.617
2013 Reyes-Robles T, Alonzo F, Kozhaya L, Lacy DB, Unutmaz D, Torres VJ. Staphylococcus aureus leukotoxin ED targets the chemokine receptors CXCR1 and CXCR2 to kill leukocytes and promote infection. Cell Host & Microbe. 14: 453-9. PMID 24139401 DOI: 10.1016/J.Chom.2013.09.005  0.434
2013 Edwards JP, Fujii H, Zhou AX, Creemers J, Unutmaz D, Shevach EM. Regulation of the expression of GARP/latent TGF-β1 complexes on mouse T cells and their role in regulatory T cell and Th17 differentiation. Journal of Immunology (Baltimore, Md. : 1950). 190: 5506-15. PMID 23645881 DOI: 10.4049/Jimmunol.1300199  0.445
2013 Zhou AX, Kozhaya L, Fujii H, Unutmaz D. GARP-TGF-β complexes negatively regulate regulatory T cell development and maintenance of peripheral CD4+ T cells in vivo. Journal of Immunology (Baltimore, Md. : 1950). 190: 5057-64. PMID 23576681 DOI: 10.4049/Jimmunol.1300065  0.58
2013 Wan Q, Kozhaya L, Imberg K, Mercer F, Zhong S, Krogsgaard M, Unutmaz D. Probing the effector and suppressive functions of human T cell subsets using antigen-specific engineered T cell receptors. Plos One. 8: e56302. PMID 23437112 DOI: 10.1371/Journal.Pone.0056302  0.598
2013 Alonzo F, Kozhaya L, Rawlings SA, Reyes-Robles T, DuMont AL, Myszka DG, Landau NR, Unutmaz D, Torres VJ. CCR5 is a receptor for Staphylococcus aureus leukotoxin ED. Nature. 493: 51-5. PMID 23235831 DOI: 10.1038/Nature11724  0.515
2013 Oswald-Richter K, Grill SM, Shariat N, Leelawong M, Sundrud MS, Haas DW, Unutmaz D. Cytokine Secretion by Treg T-cells Plos Biology. DOI: 10.1371/Journal.Pbio.0020198.G002  0.782
2013 Wan Q, Kozhaya L, Imberg K, Mercer F, Zhong S, Krogsgaard M, Unutmaz D. Correction: Probing the Effector and Suppressive Functions of Human T Cell Subsets Using Antigen-Specific Engineered T Cell Receptors Plos One. 8. DOI: 10.1371/annotation/cbc71d72-f1a2-45de-9d4a-cb0c8dc076b5  0.452
2012 Ambrose Z, Lee K, Ndjomou J, Xu H, Oztop I, Matous J, Takemura T, Unutmaz D, Engelman A, Hughes SH, KewalRamani VN. Human immunodeficiency virus type 1 capsid mutation N74D alters cyclophilin A dependence and impairs macrophage infection. Journal of Virology. 86: 4708-14. PMID 22301145 DOI: 10.1128/Jvi.05887-11  0.443
2011 Wan Q, Kozhaya L, ElHed A, Ramesh R, Carlson TJ, Djuretic IM, Sundrud MS, Unutmaz D. Cytokine signals through PI-3 kinase pathway modulate Th17 cytokine production by CCR6+ human memory T cells. The Journal of Experimental Medicine. 208: 1875-87. PMID 21825017 DOI: 10.1084/Jem.20102516  0.73
2011 Mackey-Cushman SL, Gao J, Holmes DA, Nunoya JI, Wang R, Unutmaz D, Su L. FoxP3 interacts with linker histone H1.5 to modulate gene expression and program Treg cell activity. Genes and Immunity. 12: 559-67. PMID 21654845 DOI: 10.1038/Gene.2011.31  0.502
2011 Dumont AL, Nygaard TK, Watkins RL, Smith A, Kozhaya L, Kreiswirth BN, Shopsin B, Unutmaz D, Voyich JM, Torres VJ. Characterization of a new cytotoxin that contributes to Staphylococcus aureus pathogenesis. Molecular Microbiology. 79: 814-25. PMID 21255120 DOI: 10.1111/J.1365-2958.2010.07490.X  0.386
2011 Khaitan A, Unutmaz D. Revisiting immune exhaustion during HIV infection. Current Hiv/Aids Reports. 8: 4-11. PMID 21188556 DOI: 10.1007/S11904-010-0066-0  0.566
2011 Manel N, Hogstad B, Wang Y, Levy DE, Unutmaz D, Littman DR. A cryptic sensor for HIV-1 activates antiviral innate immunity in dendritic cells (Nature (2010) 467, (214-217)) Nature. 470: 424. DOI: 10.1038/nature09813  0.35
2010 Manel N, Hogstad B, Wang Y, Levy DE, Unutmaz D, Littman DR. A cryptic sensor for HIV-1 activates antiviral innate immunity in dendritic cells. Nature. 467: 214-7. PMID 20829794 DOI: 10.1038/Nature09337  0.589
2010 Elhed A, Unutmaz D. Th17 cells and HIV infection. Current Opinion in Hiv and Aids. 5: 146-50. PMID 20543592 DOI: 10.1097/Coh.0B013E32833647A8  0.524
2010 Lee K, Ambrose Z, Martin TD, Oztop I, Mulky A, Julias JG, Vandegraaff N, Baumann JG, Wang R, Yuen W, Takemura T, Shelton K, Taniuchi I, Li Y, Sodroski J, ... ... Unutmaz D, et al. Flexible use of nuclear import pathways by HIV-1. Cell Host & Microbe. 7: 221-33. PMID 20227665 DOI: 10.1016/J.Chom.2010.02.007  0.396
2010 El Hed A, Khaitan A, Kozhaya L, Manel N, Daskalakis D, Borkowsky W, Valentine F, Littman DR, Unutmaz D. Susceptibility of human Th17 cells to human immunodeficiency virus and their perturbation during infection. The Journal of Infectious Diseases. 201: 843-54. PMID 20144043 DOI: 10.1086/651021  0.546
2010 Furtak V, Mulky A, Rawlings SA, Kozhaya L, Lee K, Kewalramani VN, Unutmaz D. Perturbation of the P-body component Mov10 inhibits HIV-1 infectivity. Plos One. 5: e9081. PMID 20140200 DOI: 10.1371/Journal.Pone.0009081  0.461
2010 Mercer F, Kozhaya L, Unutmaz D. Expression and function of TNF and IL-1 receptors on human regulatory T cells. Plos One. 5: e8639. PMID 20066156 DOI: 10.1371/Journal.Pone.0008639  0.458
2009 Mercer F, Unutmaz D. The biology of FoxP3: a key player in immune suppression during infections, autoimmune diseases and cancer. Advances in Experimental Medicine and Biology. 665: 47-59. PMID 20429415 DOI: 10.1007/978-1-4419-1599-3_4  0.441
2009 Unutmaz D, Pulendran B. The gut feeling of Treg cells: IL-10 is the silver lining during colitis. Nature Immunology. 10: 1141-3. PMID 19841645 DOI: 10.1038/Ni1109-1141  0.503
2009 Wang R, Kozhaya L, Mercer F, Khaitan A, Fujii H, Unutmaz D. Expression of GARP selectively identifies activated human FOXP3+ regulatory T cells. Proceedings of the National Academy of Sciences of the United States of America. 106: 13439-44. PMID 19666573 DOI: 10.1073/Pnas.0901965106  0.678
2009 Tran DQ, Andersson J, Wang R, Ramsey H, Unutmaz D, Shevach EM. GARP (LRRC32) is essential for the surface expression of latent TGF-beta on platelets and activated FOXP3+ regulatory T cells. Proceedings of the National Academy of Sciences of the United States of America. 106: 13445-50. PMID 19651619 DOI: 10.1073/Pnas.0901944106  0.326
2009 Unutmaz D. RORC2: the master of human Th17 cell programming. European Journal of Immunology. 39: 1452-5. PMID 19499530 DOI: 10.1002/Eji.200939540  0.534
2009 Sundrud MS, Koralov SB, Feuerer M, Calado DP, Kozhaya AE, Rhule-Smith A, Lefebvre RE, Unutmaz D, Mazitschek R, Waldner H, Whitman M, Keller T, Rao A. Halofuginone inhibits TH17 cell differentiation by activating the amino acid starvation response. Science (New York, N.Y.). 324: 1334-8. PMID 19498172 DOI: 10.1126/Science.1172638  0.719
2009 Balato A, Unutmaz D, Gaspari AA. Natural killer T cells: an unconventional T-cell subset with diverse effector and regulatory functions. The Journal of Investigative Dermatology. 129: 1628-42. PMID 19262602 DOI: 10.1038/Jid.2009.30  0.597
2009 Vetter ML, Johnson ME, Antons AK, Unutmaz D, D'Aquila RT. Differences in APOBEC3G expression in CD4+ T helper lymphocyte subtypes modulate HIV-1 infectivity. Plos Pathogens. 5: e1000292. PMID 19197360 DOI: 10.1371/Journal.Ppat.1000292  0.838
2009 Camargo JF, Quinones MP, Mummidi S, Srinivas S, Gaitan AA, Begum K, Jimenez F, VanCompernolle S, Unutmaz D, Ahuja SS, Ahuja SK. CCR5 expression levels influence NFAT translocation, IL-2 production, and subsequent signaling events during T lymphocyte activation. Journal of Immunology (Baltimore, Md. : 1950). 182: 171-82. PMID 19109148 DOI: 10.4049/Jimmunol.182.1.171  0.579
2008 Faley S, Seale K, Hughey J, Schaffer DK, VanCompernolle S, McKinney B, Baudenbacher F, Unutmaz D, Wikswo JP. Microfluidic platform for real-time signaling analysis of multiple single T cells in parallel. Lab On a Chip. 8: 1700-12. PMID 18813394 DOI: 10.1039/B719799C  0.528
2008 Antons AK, Wang R, Kalams SA, Unutmaz D. Suppression of HIV-specific and allogeneic T cell activation by human regulatory T cells is dependent on the strength of signals. Plos One. 3: e2952. PMID 18698349 DOI: 10.1371/Journal.Pone.0002952  0.83
2008 Wang R, Wan Q, Kozhaya L, Fujii H, Unutmaz D. Identification of a regulatory T cell specific cell surface molecule that mediates suppressive signals and induces Foxp3 expression. Plos One. 3: e2705. PMID 18628982 DOI: 10.1371/Journal.Pone.0002705  0.599
2008 Jiang Q, Zhang L, Wang R, Jeffrey J, Washburn ML, Brouwer D, Barbour S, Kovalev GI, Unutmaz D, Su L. FoxP3+CD4+ regulatory T cells play an important role in acute HIV-1 infection in humanized Rag2-/-gammaC-/- mice in vivo. Blood. 112: 2858-68. PMID 18544681 DOI: 10.1182/Blood-2008-03-145946  0.618
2008 Manel N, Unutmaz D, Littman DR. The differentiation of human T(H)-17 cells requires transforming growth factor-beta and induction of the nuclear receptor RORgammat. Nature Immunology. 9: 641-9. PMID 18454151 DOI: 10.1038/Ni.1610  0.472
2008 Antons AK, Wang R, Oswald-Richter K, Tseng M, Arendt CW, Kalams SA, Unutmaz D. Naive precursors of human regulatory T cells require FoxP3 for suppression and are susceptible to HIV infection. Journal of Immunology (Baltimore, Md. : 1950). 180: 764-73. PMID 18178814 DOI: 10.4049/Jimmunol.180.2.764  0.843
2008 Unutmaz D, Vilcek J. IRF1: a deus ex machina in TH1 differentiation. Nature Immunology. 9: 9-10. PMID 18087248 DOI: 10.1038/Ni0108-9  0.4
2008 Gober MD, Fishelevich R, Zhao Y, Unutmaz D, Gaspari AA. Human natural killer T cells infiltrate into the skin at elicitation sites of allergic contact dermatitis. The Journal of Investigative Dermatology. 128: 1460-9. PMID 18079745 DOI: 10.1038/Sj.Jid.5701199  0.497
2007 Torres VJ, VanCompernolle SE, Sundrud MS, Unutmaz D, Cover TL. Helicobacter pylori vacuolating cytotoxin inhibits activation-induced proliferation of human T and B lymphocyte subsets. Journal of Immunology (Baltimore, Md. : 1950). 179: 5433-40. PMID 17911630 DOI: 10.4049/Jimmunol.179.8.5433  0.783
2007 Oswald-Richter K, Grill SM, Leelawong M, Tseng M, Kalams SA, Hulgan T, Haas DW, Unutmaz D. Identification of a CCR5-expressing T cell subset that is resistant to R5-tropic HIV infection. Plos Pathogens. 3: e58. PMID 17465678 DOI: 10.1371/Journal.Ppat.0030058  0.634
2007 Mummidi S, Adams LM, VanCompernolle SE, Kalkonde M, Camargo JF, Kulkarni H, Bellinger AS, Bonello G, Tagoh H, Ahuja SS, Unutmaz D, Ahuja SK. Production of specific mRNA transcripts, usage of an alternate promoter, and octamer-binding transcription factors influence the surface expression levels of the HIV coreceptor CCR5 on primary T cells. Journal of Immunology (Baltimore, Md. : 1950). 178: 5668-81. PMID 17442950 DOI: 10.4049/Jimmunol.178.9.5668  0.515
2007 Algood HM, Torres VJ, Unutmaz D, Cover TL. Resistance of primary murine CD4+ T cells to Helicobacter pylori vacuolating cytotoxin. Infection and Immunity. 75: 334-41. PMID 17074854 DOI: 10.1128/Iai.01063-06  0.565
2006 Eger KA, Sundrud MS, Motsinger AA, Tseng M, Van Kaer L, Unutmaz D. Human natural killer T cells are heterogeneous in their capacity to reprogram their effector functions. Plos One. 1: e50. PMID 17183680 DOI: 10.1371/Journal.Pone.0000050  0.796
2006 Srivastava S, Li Z, Ko K, Choudhury P, Albaqumi M, Johnson AK, Yan Y, Backer JM, Unutmaz D, Coetzee WA, Skolnik EY. Histidine phosphorylation of the potassium channel KCa3.1 by nucleoside diphosphate kinase B is required for activation of KCa3.1 and CD4 T cells. Molecular Cell. 24: 665-75. PMID 17157250 DOI: 10.1016/J.Molcel.2006.11.012  0.417
2006 Oswald-Richter K, Torres VJ, Sundrud MS, VanCompernolle SE, Cover TL, Unutmaz D. Helicobacter pylori VacA toxin inhibits human immunodeficiency virus infection of primary human T cells. Journal of Virology. 80: 11767-75. PMID 17005643 DOI: 10.1128/Jvi.00213-06  0.811
2006 Haas DW, Geraghty DE, Andersen J, Mar J, Motsinger AA, D'Aquila RT, Unutmaz D, Benson CA, Ritchie MD, Landay A. Immunogenetics of CD4 lymphocyte count recovery during antiretroviral therapy: An AIDS Clinical Trials Group study. The Journal of Infectious Diseases. 194: 1098-107. PMID 16991084 DOI: 10.1086/507313  0.379
2006 Bezbradica JS, Gordy LE, Stanic AK, Dragovic S, Hill T, Hawiger J, Unutmaz D, Van Kaer L, Joyce S. Granulocyte-macrophage colony-stimulating factor regulates effector differentiation of invariant natural killer T cells during thymic ontogeny. Immunity. 25: 487-97. PMID 16949316 DOI: 10.1016/J.Immuni.2006.06.017  0.511
2006 Srivastava S, Ko K, Choudhury P, Li Z, Johnson AK, Nadkarni V, Unutmaz D, Coetzee WA, Skolnik EY. Phosphatidylinositol-3 phosphatase myotubularin-related protein 6 negatively regulates CD4 T cells. Molecular and Cellular Biology. 26: 5595-602. PMID 16847315 DOI: 10.1128/Mcb.00352-06  0.494
2006 Dillon S, Agrawal S, Banerjee K, Letterio J, Denning TL, Oswald-Richter K, Kasprowicz DJ, Kellar K, Pare J, van Dyke T, Ziegler S, Unutmaz D, Pulendran B. Yeast zymosan, a stimulus for TLR2 and dectin-1, induces regulatory antigen-presenting cells and immunological tolerance. The Journal of Clinical Investigation. 116: 916-28. PMID 16543948 DOI: 10.1172/Jci27203  0.399
2005 VanCompernolle SE, Taylor RJ, Oswald-Richter K, Jiang J, Youree BE, Bowie JH, Tyler MJ, Conlon JM, Wade D, Aiken C, Dermody TS, KewalRamani VN, Rollins-Smith LA, Unutmaz D. Antimicrobial peptides from amphibian skin potently inhibit human immunodeficiency virus infection and transfer of virus from dendritic cells to T cells. Journal of Virology. 79: 11598-606. PMID 16140737 DOI: 10.1128/Jvi.79.18.11598-11606.2005  0.477
2005 Sundrud MS, Vancompernolle SE, Eger KA, Bruno TC, Subramaniam A, Mummidi S, Ahuja SK, Unutmaz D. Transcription factor GATA-1 potently represses the expression of the HIV-1 coreceptor CCR5 in human T cells and dendritic cells. Blood. 106: 3440-8. PMID 16091457 DOI: 10.1182/Blood-2005-03-0857  0.816
2005 Eger KA, Unutmaz D. The innate immune system and HIV pathogenesis. Current Hiv/Aids Reports. 2: 10-5. PMID 16091243 DOI: 10.1007/S11904-996-0003-4  0.785
2005 Bezbradica JS, Stanic AK, Matsuki N, Bour-Jordan H, Bluestone JA, Thomas JW, Unutmaz D, Van Kaer L, Joyce S. Distinct roles of dendritic cells and B cells in Va14Ja18 natural T cell activation in vivo. Journal of Immunology (Baltimore, Md. : 1950). 174: 4696-705. PMID 15814694 DOI: 10.4049/Jimmunol.174.8.4696  0.532
2005 Chen J, Dang Q, Unutmaz D, Pathak VK, Maldarelli F, Powell D, Hu WS. Mechanisms of nonrandom human immunodeficiency virus type 1 infection and double infection: preference in virus entry is important but is not the sole factor. Journal of Virology. 79: 4140-9. PMID 15767415 DOI: 10.1128/Jvi.79.7.4140-4149.2005  0.518
2004 Baumann JG, Unutmaz D, Miller MD, Breun SK, Grill SM, Mirro J, Littman DR, Rein A, KewalRamani VN. Murine T cells potently restrict human immunodeficiency virus infection. Journal of Virology. 78: 12537-47. PMID 15507641 DOI: 10.1128/Jvi.78.22.12537-12547.2004  0.577
2004 Yu Q, Chen D, König R, Mariani R, Unutmaz D, Landau NR. APOBEC3B and APOBEC3C are potent inhibitors of simian immunodeficiency virus replication. The Journal of Biological Chemistry. 279: 53379-86. PMID 15466872 DOI: 10.1074/Jbc.M408802200  0.401
2004 Oswald-Richter K, Grill SM, Shariat N, Leelawong M, Sundrud MS, Haas DW, Unutmaz D. HIV infection of naturally occurring and genetically reprogrammed human regulatory T-cells. Plos Biology. 2: E198. PMID 15252446 DOI: 10.1371/Journal.Pbio.0020198  0.833
2004 Eger KA, Unutmaz D. Perturbation of natural killer cell function and receptors during HIV infection. Trends in Microbiology. 12: 301-3. PMID 15223055 DOI: 10.1016/j.tim.2004.05.006  0.806
2004 Oswald-Richter K, Grill SM, Leelawong M, Unutmaz D. HIV infection of primary human T cells is determined by tunable thresholds of T cell activation. European Journal of Immunology. 34: 1705-14. PMID 15162441 DOI: 10.1002/Eji.200424892  0.624
2004 Sundrud MS, Torres VJ, Unutmaz D, Cover TL. Inhibition of primary human T cell proliferation by Helicobacter pylori vacuolating toxin (VacA) is independent of VacA effects on IL-2 secretion. Proceedings of the National Academy of Sciences of the United States of America. 101: 7727-32. PMID 15128946 DOI: 10.1073/Pnas.0401528101  0.786
2004 Dang Q, Chen J, Unutmaz D, Coffin JM, Pathak VK, Powell D, KewalRamani VN, Maldarelli F, Hu WS. Nonrandom HIV-1 infection and double infection via direct and cell-mediated pathways. Proceedings of the National Academy of Sciences of the United States of America. 101: 632-7. PMID 14707263 DOI: 10.1073/Pnas.0307636100  0.505
2003 Hulgan T, Donahue JP, Hawkins C, Unutmaz D, D'Aquila RT, Raffanti S, Nicotera F, Rebeiro P, Erdem H, Rueff M, Haas DW. Implications of T-cell P-glycoprotein activity during HIV-1 infection and its therapy. Journal of Acquired Immune Deficiency Syndromes (1999). 34: 119-26. PMID 14526200 DOI: 10.1097/00126334-200310010-00001  0.478
2003 Sundrud MS, Grill SM, Ni D, Nagata K, Alkan SS, Subramaniam A, Unutmaz D. Genetic reprogramming of primary human T cells reveals functional plasticity in Th cell differentiation. Journal of Immunology (Baltimore, Md. : 1950). 171: 3542-9. PMID 14500650 DOI: 10.4049/Jimmunol.171.7.3542  0.793
2003 Unutmaz D. NKT cells and HIV infection. Microbes and Infection / Institut Pasteur. 5: 1041-7. PMID 12941396 DOI: 10.1016/S1286-4579(03)00185-0  0.632
2003 Jo D, Lin Q, Nashabi A, Mays DJ, Unutmaz D, Pietenpol JA, Ruley HE. Cell cycle-dependent transduction of cell-permeant Cre recombinase proteins. Journal of Cellular Biochemistry. 89: 674-87. PMID 12858334 DOI: 10.1002/Jcb.10542  0.42
2003 Motsinger A, Azimzadeh A, Stanic AK, Johnson RP, Van Kaer L, Joyce S, Unutmaz D. Identification and simian immunodeficiency virus infection of CD1d-restricted macaque natural killer T cells. Journal of Virology. 77: 8153-8. PMID 12829854 DOI: 10.1128/Jvi.77.14.8153-8158.2003  0.652
2003 McDonald D, Wu L, Bohks SM, KewalRamani VN, Unutmaz D, Hope TJ. Recruitment of HIV and its receptors to dendritic cell-T cell junctions. Science (New York, N.Y.). 300: 1295-7. PMID 12730499 DOI: 10.1126/Science.1084238  0.604
2003 Donahue JP, Dowdy D, Ratnam KK, Hulgan T, Price J, Unutmaz D, Nicotera J, Raffanti S, Becker M, Haas DW. Effects of nelfinavir and its M8 metabolite on lymphocyte P-glycoprotein activity during antiretroviral therapy. Clinical Pharmacology and Therapeutics. 73: 78-86. PMID 12545146 DOI: 10.1067/Mcp.2003.11  0.417
2002 Jung S, Unutmaz D, Wong P, Sano G, De los Santos K, Sparwasser T, Wu S, Vuthoori S, Ko K, Zavala F, Pamer EG, Littman DR, Lang RA. In vivo depletion of CD11c+ dendritic cells abrogates priming of CD8+ T cells by exogenous cell-associated antigens. Immunity. 17: 211-20. PMID 12196292 DOI: 10.1016/S1074-7613(02)00365-5  0.501
2002 Wu L, Martin TD, Vazeux R, Unutmaz D, KewalRamani VN. Functional evaluation of DC-SIGN monoclonal antibodies reveals DC-SIGN interactions with ICAM-3 do not promote human immunodeficiency virus type 1 transmission. Journal of Virology. 76: 5905-14. PMID 12021323 DOI: 10.1128/Jvi.76.12.5905-5914.2002  0.481
2002 Lundquist CA, Tobiume M, Zhou J, Unutmaz D, Aiken C. Nef-mediated downregulation of CD4 enhances human immunodeficiency virus type 1 replication in primary T lymphocytes. Journal of Virology. 76: 4625-33. PMID 11932428 DOI: 10.1128/Jvi.76.9.4625-4633.2002  0.61
2002 Motsinger A, Haas DW, Stanic AK, Van Kaer L, Joyce S, Unutmaz D. CD1d-restricted human natural killer T cells are highly susceptible to human immunodeficiency virus 1 infection. The Journal of Experimental Medicine. 195: 869-79. PMID 11927631 DOI: 10.1084/Jem.20011712  0.66
2002 Wu L, Bashirova AA, Martin TD, Villamide L, Mehlhop E, Chertov AO, Unutmaz D, Pope M, Carrington M, KewalRamani VN. Rhesus macaque dendritic cells efficiently transmit primate lentiviruses independently of DC-SIGN. Proceedings of the National Academy of Sciences of the United States of America. 99: 1568-73. PMID 11818554 DOI: 10.1073/Pnas.032654399  0.426
2001 Jo D, Nashabi A, Doxsee C, Lin Q, Unutmaz D, Chen J, Ruley HE. Epigenetic regulation of gene structure and function with a cell-permeable Cre recombinase. Nature Biotechnology. 19: 929-33. PMID 11581657 DOI: 10.1038/Nbt1001-929  0.359
2001 Unutmaz D. T cell signaling mechanisms that regulate HIV-1 infection Immunologic Research. 23: 167-177. PMID 11444382 DOI: 10.1385/Ir:23:2-3:167  0.551
2001 Campbell JJ, Qin S, Unutmaz D, Soler D, Murphy KE, Hodge MR, Wu L, Butcher EC. Unique subpopulations of CD56+ NK and NK-T peripheral blood lymphocytes identified by chemokine receptor expression repertoire Journal of Immunology. 166: 6477-6482. PMID 11359797 DOI: 10.4049/Jimmunol.166.11.6477  0.507
2000 Unutmaz D, Xiang W, Sunshine MJ, Campbell J, Butcher E, Littman DR. The primate lentiviral receptor Bonzo/STRL33 is coordinately regulated with CCR5 and its expression pattern is conserved between human and mouse Journal of Immunology. 165: 3284-3292. PMID 10975845 DOI: 10.4049/Jimmunol.165.6.3284  0.54
2000 Sun Z, Unutmaz D, Zou YR, Sunshine MJ, Pierani A, Brenner-Morton S, Mebius RE, Littman DR. Requirement for RORgamma in thymocyte survival and lymphoid organ development. Science (New York, N.Y.). 288: 2369-73. PMID 10875923 DOI: 10.1126/Science.288.5475.2369  0.436
1999 Unutmaz D, KewalRamani VN, Marmon S, Littman DR. Cytokine signals are sufficient for HIV-1 infection of resting human T lymphocytes Journal of Experimental Medicine. 189: 1735-1746. PMID 10359577 DOI: 10.1084/Jem.189.11.1735  0.646
1998 Hill CM, Kwon D, Jones M, Davis CB, Marmon S, Daugherty BL, DeMartino JA, Springer MS, Unutmaz D, Littman DR. The amino terminus of human CCR5 is required for its function as a receptor for diverse human and simian immunodeficiency virus envelope glycoproteins. Virology. 248: 357-71. PMID 9721244 DOI: 10.1006/Viro.1998.9283  0.523
1998 Unutmaz D, KewalRamani VN, Littman DR. G protein-coupled receptors in HIV and SIV entry: New perspectives on lentivirus-host interactions and on the utility of animal models Seminars in Immunology. 10: 225-236. PMID 9653049 DOI: 10.1006/Smim.1998.0134  0.406
1997 Davis CB, Dikic I, Unutmaz D, Hill CM, Arthos J, Siani MA, Thompson DA, Schlessinger J, Littman DR. Signal transduction due to HIV-1 envelope interactions with chemokine receptors CXCR4 or CCR5. The Journal of Experimental Medicine. 186: 1793-8. PMID 9362541 DOI: 10.1084/Jem.186.10.1793  0.485
1997 Hill CM, Deng H, Unutmaz D, Kewalramani VN, Bastiani L, Gorny MK, Zolla-Pazner S, Littman DR. Envelope glycoproteins from human immunodeficiency virus types 1 and 2 and simian immunodeficiency virus can use human CCR5 as a coreceptor for viral entry and make direct CD4-dependent interactions with this chemokine receptor Journal of Virology. 71: 6296-6304. PMID 9261346 DOI: 10.1128/Jvi.71.9.6296-6304.1997  0.473
1997 Deng H, Unutmaz D, Kewalramani VN, Littman DR. Expression cloning of new receptors used by simian and human immunodeficiency viruses Nature. 388: 296-300. PMID 9230441 DOI: 10.1038/40894  0.476
1997 Unutmaz D, Littman DR. Expression pattern of HIV-1 coreceptors on T cells: Implications for viral transmission and lymphocyte homing Proceedings of the National Academy of Sciences of the United States of America. 94: 1615-1618. PMID 9050826 DOI: 10.1073/Pnas.94.5.1615  0.556
1996 Deng H, Liu R, Ellmeier W, Choe S, Unutmaz D, Burkhart M, Di Marzio P, Marmon S, Sutton RE, Mark Hill C, Davis CB, Peiper SC, Schall TJ, Littman DR, Landau NR. Identification of a major co-receptor for primary isolates of HIV-1 Nature. 381: 661-666. PMID 8649511 DOI: 10.1038/381661A0  0.529
1995 Unutmaz D, Baldoni F, Abrignani S. Human naive T cells activated by cytokines differentiate into a split phenotype with functional features intermediate between naive and memory T cells International Immunology. 7: 1417-1424. PMID 7495749 DOI: 10.1093/Intimm/7.9.1417  0.613
1994 Unutmaz D, Pileri P, Abrignani S. Antigen-independent activation of naive and memory resting T cells by a cytokine combination Journal of Experimental Medicine. 180: 1159-1164. PMID 8064232 DOI: 10.1084/Jem.180.3.1159  0.578
1993 Botarelli P, Brunetto MR, Minutello MA, Calvo P, Unutmaz D, Weiner AJ, Choo Ql, Shuster JR, Kuo G, Bonino F, Houghton M, Abrignam S. T-lymphocyte response to hepatitis C virus in different clinical courses of infection Gastroenterology. 104: 580-587. PMID 8425701 DOI: 10.1016/0016-5085(93)90430-K  0.474
1993 Minutello MA, Pileri P, Unutmaz D, Censini S, Kuo G, Houghton M, Brunetto MR, Bonino F, Abrignani S. Compartmentalization of T lymphocytes to the site of disease: intrahepatic CD4+ T cells specific for the protein NS4 of hepatitis C virus in patients with chronic hepatitis C. The Journal of Experimental Medicine. 178: 17-25. PMID 8100267 DOI: 10.1084/Jem.178.1.17  0.497
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