Richard R. Tidwell - Publications

Affiliations: 
University of North Carolina, Chapel Hill, Chapel Hill, NC 
Area:
Pathology, Microbiology Biology

189 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2020 Alghamdi A, Munday JC, Campagnaro GD, Gurvic D, Svensson F, Okpara CE, Kumar A, Quintana J, Martin Abril ME, Milić P, Watson L, Paape D, Settimo L, Dimitriou A, Wielinska J, ... ... Tidwell RR, et al. Positively selected modifications in the pore of TbAQP2 allow pentamidine to enter . Elife. 9. PMID 32762841 DOI: 10.7554/eLife.56416  0.44
2017 Gillingwater K, Kunz C, Braghiroli C, Boykin DW, Tidwell RR, Brun R. In vitro, Ex vivo and In vivo Activity of Diamidines against Trypanosoma congolense and Trypanosoma vivax. Antimicrobial Agents and Chemotherapy. PMID 28193658 DOI: 10.1128/AAC.02356-16  0.44
2016 Patrick DA, Wenzler T, Yang S, Weiser PT, Wang MZ, Brun R, Tidwell RR. Synthesis of novel amide and urea derivatives of thiazol-2-ethylamines and their activity against Trypanosoma brucei rhodesiense. Bioorganic & Medicinal Chemistry. PMID 27102161 DOI: 10.1016/j.bmc.2016.04.006  0.88
2016 Pohlig G, Bernhard SC, Blum J, Burri C, Mpanya A, Lubaki JP, Mpoto AM, Munungu BF, N'tombe PM, Deo GK, Mutantu PN, Kuikumbi FM, Mintwo AF, Munungi AK, Dala A, ... ... Tidwell RR, et al. Efficacy and Safety of Pafuramidine versus Pentamidine Maleate for Treatment of First Stage Sleeping Sickness in a Randomized, Comparator-Controlled, International Phase 3 Clinical Trial. Plos Neglected Tropical Diseases. 10: e0004363. PMID 26882015 DOI: 10.1371/journal.pntd.0004363  0.88
2016 Burri C, Yeramian PD, Allen JL, Merolle A, Serge KK, Mpanya A, Lutumba P, Mesu VK, Bilenge CM, Lubaki JP, Mpoto AM, Thompson M, Munungu BF, Manuel F, Josenando T, ... ... Tidwell RR, et al. Efficacy, Safety, and Dose of Pafuramidine, a New Oral Drug for Treatment of First Stage Sleeping Sickness, in a Phase 2a Clinical Study and Phase 2b Randomized Clinical Studies. Plos Neglected Tropical Diseases. 10: e0004362. PMID 26881924 DOI: 10.1371/journal.pntd.0004362  0.88
2016 Guedes-Da-Silva FH, Batista DGJ, Meuser MB, Demarque KC, Fulco TO, Araújo JS, Da Silva PB, Da Silva CF, Patrick DA, Bakunova SM, Bakunov SA, Tidwell RR, Oliveira GM, Britto C, Moreira OC, et al. In vitro and in vivo trypanosomicidal action of novel arylimidamides against trypanosoma cruzi Antimicrobial Agents and Chemotherapy. 60: 2425-2434. DOI: 10.1128/AAC.01667-15  0.88
2015 Thuita JK, Wolf KK, Murilla GA, Bridges AS, Boykin DW, Mutuku JN, Liu Q, Jones SK, Gem CO, Ching S, Tidwell RR, Wang MZ, Paine MF, Brun R. Chemotherapy of second stage human African trypanosomiasis: comparison between the parenteral diamidine DB829 and its oral prodrug DB868 in vervet monkeys. Plos Neglected Tropical Diseases. 9: e0003409. PMID 25654243 DOI: 10.1371/journal.pntd.0003409  0.88
2014 Wenzler T, Yang S, Patrick DA, Braissant O, Ismail MA, Tidwell RR, Boykin DW, Wang MZ, Brun R. In vitro and in vivo evaluation of 28DAP010, a novel diamidine for treatment of second-stage African sleeping sickness. Antimicrobial Agents and Chemotherapy. 58: 4452-63. PMID 24867978 DOI: 10.1128/AAC.02309-13  0.88
2014 Timm BL, da Silva PB, Batista MM, da Silva FH, da Silva CF, Tidwell RR, Patrick DA, Jones SK, Bakunov SA, Bakunova SM, Soeiro Mde N. In vitro and in vivo biological effects of novel arylimidamide derivatives against Trypanosoma cruzi. Antimicrobial Agents and Chemotherapy. 58: 3720-6. PMID 24752263 DOI: 10.1128/AAC.02353-14  0.88
2014 Patrick DA, Bakunov SA, Bakunova SM, Wenzler T, Brun R, Tidwell RR. Antiprotozoal activity of dicationic 3,5-diphenylisoxazoles, their prodrugs and aza-analogues. Bioorganic & Medicinal Chemistry. 22: 559-76. PMID 24268543 DOI: 10.1016/j.bmc.2013.10.050  0.88
2014 Ju W, Yang S, Ansede JH, Stephens CE, Bridges AS, Voyksner RD, Ismail MA, Boykin DW, Tidwell RR, Hall JE, Wang MZ. CYP1A1 and CYP1B1-mediated biotransformation of the antitrypanosomal methamidoxime prodrug DB844 forms novel metabolites through intramolecular rearrangement. Journal of Pharmaceutical Sciences. 103: 337-49. PMID 24186380 DOI: 10.1002/jps.23765  0.88
2013 Patrick DA, Bakunov SA, Bakunova SM, Jones SK, Wenzler T, Barszcz T, Kumar A, Boykin DW, Werbovetz KA, Brun R, Tidwell RR. Synthesis and antiprotozoal activities of benzyl phenyl ether diamidine derivatives. European Journal of Medicinal Chemistry. 67: 310-24. PMID 23871911 DOI: 10.1016/j.ejmech.2013.06.033  0.88
2013 Patrick DA, Ismail MA, Arafa RK, Wenzler T, Zhu X, Pandharkar T, Jones SK, Werbovetz KA, Brun R, Boykin DW, Tidwell RR. Synthesis and antiprotozoal activity of dicationic m-terphenyl and 1,3-dipyridylbenzene derivatives. Journal of Medicinal Chemistry. 56: 5473-94. PMID 23795673 DOI: 10.1021/jm400508e  0.88
2013 Thuita JK, Wolf KK, Murilla GA, Liu Q, Mutuku JN, Chen Y, Bridges AS, Mdachi RE, Ismail MA, Ching S, Boykin DW, Hall JE, Tidwell RR, Paine MF, Brun R, et al. Safety, pharmacokinetic, and efficacy studies of oral DB868 in a first stage vervet monkey model of human African trypanosomiasis. Plos Neglected Tropical Diseases. 7: e2230. PMID 23755309 DOI: 10.1371/journal.pntd.0002230  0.88
2013 Takanari H, Nalos L, Stary-Weinzinger A, de Git KC, Varkevisser R, Linder T, Houtman MJ, Peschar M, de Boer TP, Tidwell RR, Rook MB, Vos MA, van der Heyden MA. Efficient and specific cardiac IK₁ inhibition by a new pentamidine analogue. Cardiovascular Research. 99: 203-14. PMID 23625347 DOI: 10.1093/cvr/cvt103  0.88
2013 Varkevisser R, Houtman MJ, Linder T, de Git KC, Beekman HD, Tidwell RR, Ijzerman AP, Stary-Weinzinger A, Vos MA, van der Heyden MA. Structure-activity relationships of pentamidine-affected ion channel trafficking and dofetilide mediated rescue. British Journal of Pharmacology. 169: 1322-34. PMID 23586323 DOI: 10.1111/bph.12208  0.88
2013 Generaux CN, Ainslie GR, Bridges AS, Ismail MA, Boykin DW, Tidwell RR, Thakker DR, Paine MF. Compartmental and enzyme kinetic modeling to elucidate the biotransformation pathway of a centrally acting antitrypanosomal prodrug. Drug Metabolism and Disposition: the Biological Fate of Chemicals. 41: 518-28. PMID 23223498 DOI: 10.1124/dmd.112.048231  0.88
2012 Harrill AH, Desmet KD, Wolf KK, Bridges AS, Eaddy JS, Kurtz CL, Hall JE, Paine MF, Tidwell RR, Watkins PB. A mouse diversity panel approach reveals the potential for clinical kidney injury due to DB289 not predicted by classical rodent models. Toxicological Sciences : An Official Journal of the Society of Toxicology. 130: 416-26. PMID 22940726 DOI: 10.1093/toxsci/kfs238  0.88
2012 Thuita JK, Wang MZ, Kagira JM, Denton CL, Paine MF, Mdachi RE, Murilla GA, Ching S, Boykin DW, Tidwell RR, Hall JE, Brun R. Pharmacology of DB844, an orally active aza analogue of pafuramidine, in a monkey model of second stage human African trypanosomiasis. Plos Neglected Tropical Diseases. 6: e1734. PMID 22848769 DOI: 10.1371/journal.pntd.0001734  0.88
2012 Liu Y, Chai Y, Kumar A, Tidwell RR, Boykin DW, Wilson WD. Designed compounds for recognition of 10 base pairs of DNA with two at binding sites. Journal of the American Chemical Society. 134: 5290-9. PMID 22369366 DOI: 10.1021/ja211628j  0.88
2012 Yan GZ, Generaux CN, Yoon M, Goldsmith RB, Tidwell RR, Hall JE, Olson CA, Clewell HJ, Brouwer KL, Paine MF. A semiphysiologically based pharmacokinetic modeling approach to predict the dose-exposure relationship of an antiparasitic prodrug/active metabolite pair. Drug Metabolism and Disposition: the Biological Fate of Chemicals. 40: 6-17. PMID 21953913 DOI: 10.1124/dmd.111.040063  0.88
2011 Mumba D, Bohorquez E, Messina J, Kande V, Taylor SM, Tshefu AK, Muwonga J, Kashamuka MM, Emch M, Tidwell R, Büscher P, Meshnick SR. Prevalence of human African trypanosomiasis in the Democratic Republic of the Congo. Plos Neglected Tropical Diseases. 5: e1246. PMID 21829736 DOI: 10.1371/journal.pntd.0001246  0.88
2011 Nehrbass-Stuedli A, Boykin D, Tidwell RR, Brun R. Novel diamidines with activity against Babesia divergens in vitro and Babesia microti in vivo. Antimicrobial Agents and Chemotherapy. 55: 3439-45. PMID 21537025 DOI: 10.1128/AAC.01482-10  0.88
2011 Yan GZ, Brouwer KL, Pollack GM, Wang MZ, Tidwell RR, Hall JE, Paine MF. Mechanisms underlying differences in systemic exposure of structurally similar active metabolites: comparison of two preclinical hepatic models. The Journal of Pharmacology and Experimental Therapeutics. 337: 503-12. PMID 21320872 DOI: 10.1124/jpet.110.177220  0.88
2011 Reid CS, Patrick DA, He S, Fotie J, Premalatha K, Tidwell RR, Wang MZ, Liu Q, Gershkovich P, Wasan KM, Wenzler T, Brun R, Werbovetz KA. Synthesis and antitrypanosomal evaluation of derivatives of N-benzyl-1,2-dihydroquinolin-6-ols: Effect of core substitutions and salt formation. Bioorganic & Medicinal Chemistry. 19: 513-23. PMID 21112788 DOI: 10.1016/j.bmc.2010.11.003  0.88
2010 Wasan EK, Gershkovich P, Zhao J, Zhu X, Werbovetz K, Tidwell RR, Clement JG, Thornton SJ, Wasan KM. A novel tropically stable oral amphotericin B formulation (iCo-010) exhibits efficacy against visceral Leishmaniasis in a murine model. Plos Neglected Tropical Diseases. 4: e913. PMID 21151883 DOI: 10.1371/journal.pntd.0000913  0.88
2010 Athri P, Wenzler T, Tidwell R, Bakunova SM, Wilson WD. Pharmacophore model for pentamidine analogs active against Plasmodium falciparum European Journal of Medicinal Chemistry. 45: 6147-6151. PMID 20884090 DOI: 10.1016/j.ejmech.2010.09.012  0.88
2010 Paine MF, Wang MZ, Generaux CN, Boykin DW, Wilson WD, De Koning HP, Olson CA, Pohlig G, Burri C, Brun R, Murilla GA, Thuita JK, Barrett MP, Tidwell RR. Diamidines for human African trypanosomiasis. Current Opinion in Investigational Drugs (London, England : 2000). 11: 876-83. PMID 20721830  0.88
2010 da Silva CF, da Silva PB, Batista MM, Daliry A, Tidwell RR, Soeiro Mde N. The biological in vitro effect and selectivity of aromatic dicationic compounds on Trypanosoma cruzi. MemóRias Do Instituto Oswaldo Cruz. 105: 239-45. PMID 20512235  0.88
2010 Goldsmith RB, Gray DR, Yan Z, Generaux CN, Tidwell RR, Reisner HM. Application of monoclonal antibodies to measure metabolism of an anti-trypanosomal compound in vitro and in vivo. Journal of Clinical Laboratory Analysis. 24: 187-94. PMID 20486201 DOI: 10.1002/jcla.20380  0.88
2010 Wang MZ, Zhu X, Srivastava A, Liu Q, Sweat JM, Pandharkar T, Stephens CE, Riccio E, Parman T, Munde M, Mandal S, Madhubala R, Tidwell RR, Wilson WD, Boykin DW, et al. Novel arylimidamides for treatment of visceral leishmaniasis. Antimicrobial Agents and Chemotherapy. 54: 2507-16. PMID 20368397 DOI: 10.1128/AAC.00250-10  0.88
2010 Gillingwater K, Kumar A, Ismail MA, Arafa RK, Stephens CE, Boykin DW, Tidwell RR, Brun R. In vitro activity and preliminary toxicity of various diamidine compounds against Trypanosoma evansi. Veterinary Parasitology. 169: 264-72. PMID 20149544 DOI: 10.1016/j.vetpar.2010.01.019  0.88
2010 Gershkovich P, Wasan EK, Sivak O, Li R, Zhu X, Werbovetz KA, Tidwell RR, Clement JG, Thornton SJ, Wasan KM. Visceral leishmaniasis affects liver and spleen concentrations of amphotericin B following administration to mice. The Journal of Antimicrobial Chemotherapy. 65: 535-7. PMID 20026611 DOI: 10.1093/jac/dkp465  0.88
2010 Bakunov SA, Bakunova SM, Wenzler T, Ghebru M, Werbovetz KA, Brun R, Tidwell RR. Synthesis and antiprotozoal activity of cationic 1,4-diphenyl-1H-1,2,3-triazoles. Journal of Medicinal Chemistry. 53: 254-72. PMID 19928900 DOI: 10.1021/jm901178d  0.88
2010 Rosypal AC, Tripp S, Kinlaw C, Hailemariam S, Tidwell RR, Lindsay DS, Rajapakse RP, Sreekumar C, Dubey JP. Surveillance for antibodies to Leishmania spp. in dogs from Sri Lanka. The Journal of Parasitology. 96: 230-1. PMID 19803542 DOI: 10.1645/GE-2288  0.88
2009 Gillingwater K, Kumar A, Anbazhagan M, Boykin DW, Tidwell RR, Brun R. In vivo investigations of selected diamidine compounds against Trypanosoma evansi using a mouse model. Antimicrobial Agents and Chemotherapy. 53: 5074-9. PMID 19786604 DOI: 10.1128/AAC.00422-09  0.88
2009 Bakunov SA, Bakunova SM, Bridges AS, Wenzler T, Barszcz T, Werbovetz KA, Brun R, Tidwell RR. Synthesis and antiprotozoal properties of pentamidine congeners bearing the benzofuran motif. Journal of Medicinal Chemistry. 52: 5763-7. PMID 19757840 DOI: 10.1021/jm9006406  0.88
2009 Daliry A, Da Silva PB, Da Silva CF, Batista MM, De Castro SL, Tidwell RR, Soeiro Mde N. In vitro analyses of the effect of aromatic diamidines upon Trypanosoma cruzi. The Journal of Antimicrobial Chemotherapy. 64: 747-50. PMID 19671588 DOI: 10.1093/jac/dkp290  0.88
2009 Wenzler T, Boykin DW, Ismail MA, Hall JE, Tidwell RR, Brun R. New treatment option for second-stage African sleeping sickness: in vitro and in vivo efficacy of aza analogs of DB289. Antimicrobial Agents and Chemotherapy. 53: 4185-92. PMID 19620327 DOI: 10.1128/AAC.00225-09  0.88
2009 Bakunova SM, Bakunov SA, Wenzler T, Barszcz T, Werbovetz KA, Brun R, Tidwell RR. Synthesis and antiprotozoal activity of pyridyl analogues of pentamidine. Journal of Medicinal Chemistry. 52: 4657-67. PMID 19606902 DOI: 10.1021/jm900805v  0.88
2009 Wasan KM, Wasan EK, Gershkovich P, Zhu X, Tidwell RR, Werbovetz KA, Clement JG, Thornton SJ. Highly effective oral amphotericin B formulation against murine visceral leishmaniasis. The Journal of Infectious Diseases. 200: 357-60. PMID 19545212 DOI: 10.1086/600105  0.88
2009 Purfield AE, Tidwell RR, Meshnick SR. The diamidine DB75 targets the nucleus of Plasmodium falciparum. Malaria Journal. 8: 104. PMID 19442305 DOI: 10.1186/1475-2875-8-104  0.88
2009 Patrick DA, Bakunov SA, Bakunova SM, Kumar EV, Chen H, Jones SK, Wenzler T, Barzcz T, Werbovetz KA, Brun R, Tidwell RR. Synthesis and antiprotozoal activities of dicationic bis(phenoxymethyl)benzenes, bis(phenoxymethyl)naphthalenes, and bis(benzyloxy)naphthalenes. European Journal of Medicinal Chemistry. 44: 3543-51. PMID 19409677 DOI: 10.1016/j.ejmech.2009.03.014  0.88
2009 Bakunova SM, Bakunov SA, Patrick DA, Kumar EV, Ohemeng KA, Bridges AS, Wenzler T, Barszcz T, Jones SK, Werbovetz KA, Brun R, Tidwell RR. Structure-activity study of pentamidine analogues as antiprotozoal agents. Journal of Medicinal Chemistry. 52: 2016-35. PMID 19267462 DOI: 10.1021/jm801547t  0.88
2009 Rahimian M, Kumar A, Say M, Bakunov SA, Boykin DW, Tidwell RR, Wilson WD. Minor groove binding compounds that jump a gc base pair and bind to adjacent AT base pair sites. Biochemistry. 48: 1573-83. PMID 19173620 DOI: 10.1021/bi801944g  0.88
2009 Mdachi RE, Thuita JK, Kagira JM, Ngotho JM, Murilla GA, Ndung'u JM, Tidwell RR, Hall JE, Brun R. Efficacy of the novel diamidine compound 2,5-Bis(4-amidinophenyl)-furan- bis-O-methlylamidoxime (pafuramidine, DB289) against Trypanosoma brucei rhodesiense infection in vervet monkeys after oral administration Antimicrobial Agents and Chemotherapy. 53: 953-957. PMID 19064893 DOI: 10.1128/AAC.00831-08  0.88
2009 Ming X, Ju W, Wu H, Tidwell RR, Hall JE, Thakker DR. Transport of dicationic drugs pentamidine and furamidine by human organic cation transporters. Drug Metabolism and Disposition: the Biological Fate of Chemicals. 37: 424-30. PMID 18971316 DOI: 10.1124/dmd.108.024083  0.88
2009 Rosypal AC, Hailemariam S, Wekheye V, Huong LT, Dubey JP, Lindsay DS, Tidwell RR. Survey of dogs from Vietnam for antibodies to visceralizing Leishmania spp. The Journal of Parasitology. 95: 767. PMID 18939898 DOI: 10.1645/GE-1828.1  0.88
2008 Bakunov SA, Bakunova SM, Wenzler T, Barszcz T, Werbovetz KA, Brun R, Tidwell RR. Synthesis and antiprotozoal activity of cationic 2-phenylbenzofurans. Journal of Medicinal Chemistry. 51: 6927-44. PMID 18841956 DOI: 10.1021/jm800918v  0.88
2008 Wang MZ, Wu JQ, Dennison JB, Bridges AS, Hall SD, Kornbluth S, Tidwell RR, Smith PC, Voyksner RD, Paine MF, Hall JE. A gel-free MS-based quantitative proteomic approach accurately measures cytochrome P450 protein concentrations in human liver microsomes. Proteomics. 8: 4186-96. PMID 18792928 DOI: 10.1002/pmic.200800144  0.88
2008 Thuita JK, Karanja SM, Wenzler T, Mdachi RE, Ngotho JM, Kagira JM, Tidwell R, Brun R. Efficacy of the diamidine DB75 and its prodrug DB289, against murine models of human African trypanosomiasis Acta Tropica. 108: 6-10. PMID 18722336 DOI: 10.1016/j.actatropica.2008.07.006  0.88
2008 Rosypal AC, Werbovetz KA, Salem M, Stephens CE, Kumar A, Boykin DW, Hall JE, Tidwell RR. Inhibition by Dications of in vitro growth of Leishmania major and Leishmania tropica: causative agents of old world cutaneous leishmaniasis. The Journal of Parasitology. 94: 743-9. PMID 18605790 DOI: 10.1645/GE-1387.1  0.88
2008 Purfield AE, Tidwell RR, Meshnick SR. Interactions of DB75, a novel antimalarial agent, with other antimalarial drugs in vitro. Antimicrobial Agents and Chemotherapy. 52: 2253-5. PMID 18362196 DOI: 10.1128/AAC.01536-07  0.88
2008 Lanteri CA, Tidwell RR, Meshnick SR. The mitochondrion is a site of trypanocidal action of the aromatic diamidine DB75 in bloodstream forms of Trypanosoma brucei. Antimicrobial Agents and Chemotherapy. 52: 875-82. PMID 18086841 DOI: 10.1128/AAC.00642-07  0.88
2008 Rahmathullah SM, Tidwell RR, Jones SK, Hall JE, Boykin DW. Carbamate prodrugs of N-alkylfuramidines. European Journal of Medicinal Chemistry. 43: 174-7. PMID 17499888 DOI: 10.1016/j.ejmech.2007.03.009  0.88
2007 Bakunova SM, Bakunov SA, Wenzler T, Barszcz T, Werbovetz KA, Brun R, Hall JE, Tidwell RR. Synthesis and in vitro antiprotozoal activity of bisbenzofuran cations. Journal of Medicinal Chemistry. 50: 5807-23. PMID 17948982 DOI: 10.1021/jm0708634  0.88
2007 Rosypal AC, Tidwell RR, Lindsay DS. Prevalence of antibodies to Leishmania infantum and Trypanosoma cruzi in wild canids from South Carolina. The Journal of Parasitology. 93: 955-7. PMID 17918387 DOI: 10.1645/GE-1057R.1  0.88
2007 Rosypal AC, Cortés-Vecino JA, Gennari SM, Dubey JP, Tidwell RR, Lindsay DS. Serological survey of Leishmania infantum and Trypanosoma cruzi in dogs from urban areas of Brazil and Colombia. Veterinary Parasitology. 149: 172-7. PMID 17825991 DOI: 10.1016/j.vetpar.2007.08.004  0.88
2007 Wang MZ, Wu JQ, Bridges AS, Zeldin DC, Kornbluth S, Tidwell RR, Hall JE, Paine MF. Human enteric microsomal CYP4F enzymes O-demethylate the antiparasitic prodrug pafuramidine. Drug Metabolism and Disposition: the Biological Fate of Chemicals. 35: 2067-75. PMID 17709372 DOI: 10.1124/dmd.107.016428  0.88
2007 Barrett MP, Boykin DW, Brun R, Tidwell RR. Human African trypanosomiasis: pharmacological re-engagement with a neglected disease. British Journal of Pharmacology. 152: 1155-71. PMID 17618313 DOI: 10.1038/sj.bjp.0707354  0.88
2007 Mathis AM, Bridges AS, Ismail MA, Kumar A, Francesconi I, Anbazhagan M, Hu Q, Tanious FA, Wenzler T, Saulter J, Wilson WD, Brun R, Boykin DW, Tidwell RR, Hall JE. Diphenyl furans and aza analogs: effects of structural modification on in vitro activity, DNA binding, and accumulation and distribution in trypanosomes. Antimicrobial Agents and Chemotherapy. 51: 2801-10. PMID 17517831 DOI: 10.1128/AAC.00005-07  0.88
2007 Tanious FA, Laine W, Peixoto P, Bailly C, Goodwin KD, Lewis MA, Long EC, Georgiadis MM, Tidwell RR, Wilson WD. Unusually strong binding to the DNA minor groove by a highly twisted benzimidazole diphenylether: induced fit and bound water. Biochemistry. 46: 6944-56. PMID 17506529 DOI: 10.1021/bi700288g  0.88
2007 Patrick DA, Bakunov SA, Bakunova SM, Kumar EV, Lombardy RJ, Jones SK, Bridges AS, Zhirnov O, Hall JE, Wenzler T, Brun R, Tidwell RR. Synthesis and in vitro antiprotozoal activities of dicationic 3,5-diphenylisoxazoles. Journal of Medicinal Chemistry. 50: 2468-85. PMID 17439202 DOI: 10.1021/jm0612867  0.88
2007 Rosypal AC, Hall JE, Bakunova S, Patrick DA, Bakunov S, Stephens CE, Kumar A, Boykin DW, Tidwell RR. In vitro activity of dicationic compounds against a North American foxhound isolate of Leishmania infantum. Veterinary Parasitology. 145: 207-16. PMID 17298866 DOI: 10.1016/j.vetpar.2007.01.005  0.88
2006 Wang MZ, Saulter JY, Usuki E, Cheung YL, Hall M, Bridges AS, Loewen G, Parkinson OT, Stephens CE, Allen JL, Zeldin DC, Boykin DW, Tidwell RR, Parkinson A, Paine MF, et al. CYP4F enzymes are the major enzymes in human liver microsomes that catalyze the O-demethylation of the antiparasitic prodrug DB289 [2,5-bis(4-amidinophenyl)furan-bis-O-methylamidoxime]. Drug Metabolism and Disposition: the Biological Fate of Chemicals. 34: 1985-94. PMID 16997912 DOI: 10.1124/dmd.106.010587  0.88
2006 Lanteri CA, Stewart ML, Brock JM, Alibu VP, Meshnick SR, Tidwell RR, Barrett MP. Roles for the Trypanosoma brucei P2 transporter in DB75 uptake and resistance. Molecular Pharmacology. 70: 1585-92. PMID 16912218 DOI: 10.1124/mol.106.024653  0.88
2006 Goodwin KD, Lewis MA, Tanious FA, Tidwell RR, Wilson WD, Georgiadis MM, Long EC. A high-throughput, high-resolution strategy for the study of site-selective DNA binding agents: analysis of a "highly twisted" benzimidazole-diamidine. Journal of the American Chemical Society. 128: 7846-54. PMID 16771498 DOI: 10.1021/ja0600936  0.88
2006 Mathis AM, Holman JL, Sturk LM, Ismail MA, Boykin DW, Tidwell RR, Hall JE. Accumulation and intracellular distribution of antitrypanosomal diamidine compounds DB75 and DB820 in African trypanosomes. Antimicrobial Agents and Chemotherapy. 50: 2185-91. PMID 16723581 DOI: 10.1128/AAC.00192-06  0.88
2006 Athri P, Wenzler T, Ruiz P, Brun R, Boykin DW, Tidwell R, Wilson WD. 3D QSAR on a library of heterocyclic diamidine derivatives with antiparasitic activity. Bioorganic & Medicinal Chemistry. 14: 3144-52. PMID 16442293 DOI: 10.1016/j.bmc.2005.12.029  0.88
2005 Saulter JY, Kurian JR, Trepanier LA, Tidwell RR, Bridges AS, Boykin DW, Stephens CE, Anbazhagan M, Hall JE. Unusual dehydroxylation of antimicrobial amidoxime prodrugs by cytochrome b5 and NADH cytochrome b5 reductase. Drug Metabolism and Disposition: the Biological Fate of Chemicals. 33: 1886-93. PMID 16131524 DOI: 10.1124/dmd.105.005017  0.88
2005 Stewart ML, Krishna S, Burchmore RJ, Brun R, de Koning HP, Boykin DW, Tidwell RR, Hall JE, Barrett MP. Detection of arsenical drug resistance in Trypanosoma brucei with a simple fluorescence test. Lancet (London, England). 366: 486-7. PMID 16084257 DOI: 10.1016/S0140-6736(05)66793-1  0.88
2005 Ansede JH, Voyksner RD, Ismail MA, Boykin DW, Tidwell RR, Hall JE. In vitro metabolism of an orally active O-methyl amidoxime prodrug for the treatment of CNS trypanosomiasis Xenobiotica. 35: 211-226. PMID 16019947 DOI: 10.1080/00498250500087671  0.88
2005 Yeramian P, Meshnick SR, Krudsood S, Chalermrut K, Silachamroon U, Tangpukdee N, Allen J, Brun R, Kwiek JJ, Tidwell R, Looareesuwan S. Efficacy of DB289 in Thai patients with Plasmodium vivax or acute, uncomplicated Plasmodium falciparum infections. The Journal of Infectious Diseases. 192: 319-22. PMID 15962227 DOI: 10.1086/430928  0.88
2004 Lanteri CA, Trumpower BL, Tidwell RR, Meshnick SR. DB75, a novel trypanocidal agent, disrupts mitochondrial function in Saccharomyces cerevisiae. Antimicrobial Agents and Chemotherapy. 48: 3968-74. PMID 15388460 DOI: 10.1128/AAC.48.10.3968-3974.2004  0.88
2004 Sturk LM, Brock JL, Bagnell CR, Hall JE, Tidwell RR. Distribution and quantitation of the anti-trypanosomal diamidine 2,5-bis(4-amidinophenyl)furan (DB75) and its N-methoxy prodrug DB289 in murine brain tissue. Acta Tropica. 91: 131-43. PMID 15234662 DOI: 10.1016/j.actatropica.2004.03.010  0.88
2004 Rezk NL, Tidwell RR, Kashuba AD. High-performance liquid chromatography assay for the quantification of HIV protease inhibitors and non-nucleoside reverse transcriptase inhibitors in human plasma. Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences. 805: 241-7. PMID 15135096 DOI: 10.1016/j.jchromb.2004.03.002  0.88
2004 Zhou L, Thakker DR, Voyksner RD, Anbazhagan M, Boykin DW, Hall JE, Tidwell RR. Metabolites of an orally active antimicrobial prodrug, 2,5-bis(4-amidinophenyl)furan-bis-O-methylamidoxime, identified by liquid chromatography/tandem mass spectrometry. Journal of Mass Spectrometry : Jms. 39: 351-60. PMID 15103648 DOI: 10.1002/jms.591  0.88
2003 Rezk NL, Tidwell RR, Kashuba AD. Simultaneous determination of six HIV nucleoside analogue reverse transcriptase inhibitors and nevirapine by liquid chromatography with ultraviolet absorbance detection. Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences. 791: 137-47. PMID 12798174 DOI: 10.1016/S1570-0232(03)00224-1  0.88
2002 Zhou L, Lee K, Thakker DR, Boykin DW, Tidwell RR, Hall JE. Enhanced permeability of the antimicrobial agent 2,5-bis(4-amidinophenyl)furan across Caco-2 cell monolayers via its methylamidoidme prodrug. Pharmaceutical Research. 19: 1689-95. PMID 12458675 DOI: 10.1023/A:1020957430400  0.88
2002 Pereira AS, Smeaton LM, Gerber JG, Acosta EP, Snyder S, Fiscus SA, Tidwell RR, Gulick RM, Murphy RL, Eron JJ. The pharmacokinetics of amprenavir, zidovudine, and lamivudine in the genital tracts of men infected with human immunodeficiency virus type 1 (AIDS clinical trials group study 850). The Journal of Infectious Diseases. 186: 198-204. PMID 12134255 DOI: 10.1086/341209  0.88
2002 Rezk NL, Tidwell RR, Kashuba AD. Simple and rapid quantification of the non-nucleoside reverse transcriptase inhibitors nevirapine, delavirdine, and efavirenz in human blood plasma using high-performance liquid chromatography with ultraviolet absorbance detection. Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences. 774: 79-88. PMID 12052725 DOI: 10.1016/S1570-0232(02)00210-6  0.88
2002 Zhou L, Voyksner RD, Thakker DR, Stephens CE, Anbazhagan M, Boykin DW, Hall JE, Tidwell RR. Characterizing the fragmentation of 2,5-bis (4-amidinophenyl)furan-bis-O-methylamidoxime and selected metabolites using ion trap mass spectrometry. Rapid Communications in Mass Spectrometry : Rcm. 16: 1078-85. PMID 11992511 DOI: 10.1002/rcm.676  0.88
2002 Brendle JJ, Outlaw A, Kumar A, Boykin DW, Patrick DA, Tidwell RR, Werbovetz KA. Antileishmanial activities of several classes of aromatic dications Antimicrobial Agents and Chemotherapy. 46: 797-807. PMID 11850264 DOI: 10.1128/AAC.46.3.797-807.2002  0.88
2002 Pereira AS, Kenney KB, Cohen MS, Eron JJ, Tidwell RR, Dunn JA. Determination of amprenavir, a HIV-1 protease inhibitor, in human seminal plasma using high-performance liquid chromatography-tandem mass spectrometry. Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences. 766: 307-17. PMID 11824819 DOI: 10.1016/S0378-4347(01)00512-6  0.88
2002 Zhou L, Thakker DR, Voyksner RD, Anbazhagan M, Boykin DW, Hall JE, Tidwell RR. Metabolites of an orally active antimicrobial prodrug, 2,5-bis(4- amidinophenyl)furan-bis-O-methylamidoxime, identified by liquid chromatography-tandem mass spectrometry Proceedings 50th Asms Conference On Mass Spectrometry and Allied Topics. 467-468.  0.88
2002 Zhou L, Voyksner RD, Thakker DR, Stephens CE, Anbazhagan M, Boykin DW, Tidwell RR, Hall JE. A novel fragmentation pathway involving formation of radical product ions from an antimicrobial prodrug DB289 and selected metabolites using ion trap mass spectrometry Proceedings 50th Asms Conference On Mass Spectrometry and Allied Topics. 479-480.  0.88
2001 Pereira AS, Tidwell RR. Separation methods for nucleoside analogues used for treatment of HIV-1 infection. Journal of Chromatography. B, Biomedical Sciences and Applications. 764: 327-47. PMID 11817036 DOI: 10.1016/S0378-4347(01)00347-4  0.88
2001 Tanious FA, Wilson WD, Patrick DA, Tidwell RR, Colson P, Houssier C, Tardy C, Bailly C. Sequence-dependent binding of bis-amidine carbazole dications to DNA. European Journal of Biochemistry / Febs. 268: 3455-64. PMID 11422375 DOI: 10.1046/j.1432-1327.2001.02242.x  0.88
2001 Stephens CE, Patrick DA, Chen H, Tidwell RR, Boykin DW. Synthesis of deuterium-labelled 2,5-bis(4-amidinophenyl)furan, 2,5-bis[4-(methoxyamidino)phenyl]furan, and 2,7-diamidinocarbazole Journal of Labelled Compounds and Radiopharmaceuticals. 44: 197-208. DOI: 10.1002/jlcr.444  0.88
2000 Tanious FA, Ding D, Patrick DA, Bailly C, Tidwell RR, Wilson WD. Effects of compound structure on carbazole dication-DNA complexes: tests of the minor-groove complex models. Biochemistry. 39: 12091-101. PMID 11009625 DOI: 10.1021/bi001236i  0.88
2000 Pereira AS, Kenney KB, Cohen MS, Hall JE, Eron JJ, Tidwell RR, Dunn JA. Simultaneous determination of lamivudine and zidovudine concentrations in human seminal plasma using high-performance liquid chromatography and tandem mass spectrometry. Journal of Chromatography. B, Biomedical Sciences and Applications. 742: 173-83. PMID 10892596 DOI: 10.1016/S0378-4347(00)00162-6  0.88
2000 Reisner HM, Gray DR, Jones SK, Rose BG, Tidwell RR. Immunoassays for pentamidine and related compounds: development of a facile inhibitory ELISA suitable for clinical use. Journal of Clinical Laboratory Analysis. 14: 73-82. PMID 10683618 DOI: 10.1002/(SICI)1098-2825(2000)14:2<73::AID-JCLA7>3.0.CO;2-G  0.88
1999 Patrick DA, Hall JE, Bender BC, McCurdy DR, Wilson WD, Tanious FA, Saha S, Tidwell RR. Synthesis and anti-Pneumocystis carinii pneumonia activity of novel dicationic dibenzothiophenes and orally active prodrugs European Journal of Medicinal Chemistry. 34: 575-583. PMID 11278043  0.88
1999 Pereira AS, Kashuba AD, Fiscus SA, Hall JE, Tidwell RR, Troiani L, Dunn JA, Eron JJ, Cohen MS. Nucleoside analogues achieve high concentrations in seminal plasma: relationship between drug concentration and virus burden. The Journal of Infectious Diseases. 180: 2039-43. PMID 10558966 DOI: 10.1086/315149  0.88
1999 Rahmathullah SM, Hall JE, Bender BC, McCurdy DR, Tidwell RR, Boykin DW. Prodrugs for amidines: Synthesis and anti-Pneumocystis carinii activity of carbamates of 2,5-bis(4-amidinophenyl)furan Journal of Medicinal Chemistry. 42: 3994-4000. PMID 10508447 DOI: 10.1021/jm990237+  0.88
1999 Del Poeta M, Bixel AS, Barchiesi F, Tidwell RR, Boykin D, Scalise G, Perfect JR. In-vitro activity of dicationic aromatic compounds and fluconazole against Cryptococcus neoformans and Candida spp Journal of Antimicrobial Chemotherapy. 44: 223-228. PMID 10473229 DOI: 10.1093/jac/44.2.223  0.88
1999 Wood DH, Hall JE, Rose BG, Boykin DW, Tidwell RR. Pentamidine is a potent inhibitor of [3H]idazoxan binding to imidazoline I2 receptors. Annals of the New York Academy of Sciences. 881: 110-3. PMID 10415905 DOI: 10.1111/j.1749-6632.1999.tb09349.x  0.88
1999 Francesconi I, Wilson WD, Tanious FA, Hall JE, Bender BC, Tidwell RR, McCurdy D, Boykin DW. 2,4-Diphenyl furan diamidines as novel anti-Pneumocystis carinii pneumonia agents. Journal of Medicinal Chemistry. 42: 2260-5. PMID 10377232 DOI: 10.1021/jm990071c  0.88
1999 Wang S, Hall JE, Tanious FA, Wilson WD, Patrick DA, McCurdy DR, Bender BC, Tidwell RR. Dicationic dibenzofuran derivatives as anti-Pneumocystis carinii pneumonia agents: Synthesis, DNA binding affinity, and anti-P. carinii activity in an immunosuppressed rat model European Journal of Medicinal Chemistry. 34: 215-224. DOI: 10.1016/S0223-5234(99)80054-3  0.88
1998 Blagburn BL, Drain KL, Land TM, Kinard RG, Moore PH, Lindsay DS, Patrick DA, Boykin DW, Tidwell RR. Comparative efficacy evaluation of dicationic carbazole compounds, nitazoxanide, and paromomycin against Cryptosporidium parvum infections in a neonatal mouse model. Antimicrobial Agents and Chemotherapy. 42: 2877-82. PMID 9797219  0.88
1998 Del Poeta M, Schell WA, Dykstra CC, Jones SK, Tidwell RR, Kumar A, Boykin DW, Perfect JR. In vitro antifungal activities of a series of dication-substituted carbazoles, furans, and benzimidazoles. Antimicrobial Agents and Chemotherapy. 42: 2503-10. PMID 9756748  0.88
1998 Del Poeta M, Schell WA, Dykstra CC, Jones S, Tidwell RR, Czarny A, Bajic M, Kumar A, Boykin D, Perfect JR. Structure-in vitro activity relationships of pentamidine analogues and dication-substituted bis-benzimidazoles as new antifungal agents Antimicrobial Agents and Chemotherapy. 42: 2495-2502. PMID 9756747  0.88
1998 Hopkins KT, Wilson WD, Bender BC, McCurdy DR, Hall JE, Tidwell RR, Kumar A, Bajic M, Boykin DW. Extended aromatic furan amidino derivatives as anti-Pneumocystis carinii agents. Journal of Medicinal Chemistry. 41: 3872-8. PMID 9748362 DOI: 10.1021/jm980230c  0.88
1998 Wood DH, Hall JE, Rose BG, Tidwell RR. 1,5-Bis(4-amidinophenoxy)pentane (pentamidine) is a potent inhibitor of [3H]idazoxan binding to imidazoline I2 binding sites. European Journal of Pharmacology. 353: 97-103. PMID 9721046 DOI: 10.1016/S0014-2999(98)00386-0  0.88
1998 Blagburn BL, Drain KL, Land TM, Moore PH, Kinard RG, Lindsay DS, Kumar A, Shi J, Boykin DW, Tidwell RR. Dicationic furans inhibit development of Cryptosporidium parvum in HSD/ICR suckling Swiss mice. The Journal of Parasitology. 84: 851-6. PMID 9714224 DOI: 10.2307/3284603  0.88
1998 Hall JE, Kerrigan JE, Ramachandran K, Bender BC, Stanko JP, Jones SK, Patrick DA, Tidwell RR. Anti-Pneumocystis activities of aromatic diamidoxime prodrugs. Antimicrobial Agents and Chemotherapy. 42: 666-74. PMID 9517949  0.88
1998 Hildebrandt E, Boykin DW, Kumar A, Tidwell RR, Dykstra CC. Identification and characterization of an endo/exonuclease in Pneumocystis carinii that is inhibited by dicationic diarylfurans with efficacy against Pneumocystis pneumonia. The Journal of Eukaryotic Microbiology. 45: 112-21. PMID 9495040  0.88
1998 Boykin DW, Kumar A, Xiao G, Wilson WD, Bender BC, McCurdy DR, Hall JE, Tidwell RR. 2,5-bis[4-(N-alkylamidino)phenyl]furans as anti-Pneumocystis carinii agents. Journal of Medicinal Chemistry. 41: 124-9. PMID 9438029 DOI: 10.1021/jm970570i  0.88
1998 Boykin DW, Kumar A, Bajic M, Xiao G, Wilson WD, Bender BC, McCurdy DR, Hall JE, Tidwell RR. Anti-Pneumocystis carinii pneumonia activity of dicationic diaryl methylpyrimidines European Journal of Medicinal Chemistry. 32: 965-972. DOI: 10.1016/S0223-5234(97)89640-7  0.88
1997 Tanious FA, Ding D, Patrick DA, Tidwell RR, Wilson WD. A new type of DNA minor-groove complex: carbazole dication-DNA interactions. Biochemistry. 36: 15315-25. PMID 9398260 DOI: 10.1021/bi971599r  0.88
1997 Tuttle RH, Hall JE, Tidwell RR. High-performance liquid chromatographic assay detects pentamidine metabolism by Fisher rat liver microsomes. Journal of Chromatography. B, Biomedical Sciences and Applications. 688: 319-24. PMID 9061470 DOI: 10.1016/S0378-4347(96)00288-5  0.88
1997 Patrick DA, Boykin DW, Wilson WD, Tanious FA, Spychala J, Bender BC, Hall JE, Dykstra CC, Ohemeng KA, Tidwell RR. Anti-Pneumocystis carinii pneumonia activity of dicationic carbazoles European Journal of Medicinal Chemistry. 32: 781-793. DOI: 10.1016/S0223-5234(99)80064-6  0.88
1996 Trent JO, Clark GR, Kumar A, Wilson WD, Boykin DW, Hall JE, Tidwell RR, Blagburn BL, Neidle S. Targeting the minor groove of DNA: crystal structures of two complexes between furan derivatives of berenil and the DNA dodecamer d(CGCGAATTCGCG)2. Journal of Medicinal Chemistry. 39: 4554-62. PMID 8917643 DOI: 10.1021/jm9604484  0.88
1996 Lombardy RL, Tanious FA, Ramachandran K, Tidwell RR, Wilson WD. Synthesis and DNA interactions of benzimidazole dications which have activity against opportunistic infections. Journal of Medicinal Chemistry. 39: 1452-62. PMID 8691476 DOI: 10.1021/jm9507946  0.88
1996 Boykin DW, Kumar A, Hall JE, Bender BC, Tidwell RR. Anti-pneumocystis activity of bis-amidoximes and bis-O-alkylamidoximes prodrugs Bioorganic and Medicinal Chemistry Letters. 6: 3017-3020. DOI: 10.1016/S0960-894X(96)00557-4  0.88
1996 Kumar A, Boykin DW, Wilson WD, Jones SK, Bender BK, Dykstra CC, Hall JE, Tidwell RR. Anti-Pneumocystis carinii pneumonia activity of dicationic 2,4-diarylpyrimidines European Journal of Medicinal Chemistry. 31: 767-773. DOI: 10.1016/0223-5234(96)83970-5  0.88
1995 Keku TO, Seed JR, Tidwell RR. The in vitro HL-60 cell--Trypanosoma brucei rhodesiense culture system: a rapid in vitro drug screen. Tropical Medicine and Parasitology : Official Organ of Deutsche Tropenmedizinische Gesellschaft and of Deutsche Gesellschaft FüR Technische Zusammenarbeit (Gtz). 46: 258-62. PMID 8826107  0.88
1995 Bronner U, Ericsson O, Nordin J, Wikström I, Abdi YA, Hall JE, Tidwell RR, Gustafsson LL. Metabolism is an important route of pentamidine elimination in the rat: disposition of 14C-pentamidine and identification of metabolites in urine using liquid chromatography-tandem mass spectrometry. Pharmacology & Toxicology. 77: 114-20. PMID 8584501  0.88
1995 Boykin DW, Kumar A, Spychala J, Zhou M, Lombardy RJ, Wilson WD, Dykstra CC, Jones SK, Hall JE, Tidwell RR. Dicationic diarylfurans as anti-Pneumocystis carinii agents. Journal of Medicinal Chemistry. 38: 912-6. PMID 7699707 DOI: 10.1021/jm00006a009  0.88
1995 Geratz JD, Pryzwansky KB, Anderle SK, Tidwell RR. Control of glucan-induced systemic granulomatosis by cyclosporine A. Inflammation. 19: 221-31. PMID 7601507 DOI: 10.1007/BF01534463  0.88
1995 Kumar A, Rhodes RA, Spychala J, Wilson WD, Boykin DW, Tidwell RR, Dykstra CC, Hall JE, Jones SK, Schinazi RF. Synthesis of dicationic diarylpyridines as nucleic-acid binding agents European Journal of Medicinal Chemistry. 30: 99-106. DOI: 10.1016/0223-5234(96)88214-6  0.88
1995 Van Breemen RB, Jiang O, Tidwell RR, Hall JE, Brewer TG. Fast atom bombardment tandem mass spectrometry of the anti-parasitic agent pentamidine and its oxygenated metabolites Journal of Mass Spectrometry. 30: 549-556.  0.88
1994 Liu Yong, Tidwell RR, Leibowitz MJ. Inhibition of in vitro splicing of a group I intron of Pneumocystis carinii Journal of Eukaryotic Microbiology. 41: 31-38. PMID 8124264 DOI: 10.1111/j.1550-7408.1994.tb05931.x  0.88
1994 Fletcher LD, McDowell JM, Tidwell RR, Meagher RB, Dykstra CC. Structure, expression and phylogenetic analysis of the gene encoding actin I in Pneumocystis carinii Genetics. 137: 743-750. PMID 8088520  0.88
1994 Lindsay DS, Rippey NS, Cole RA, Parsons LC, Dubey JP, Tidwell RR, Blagburn BL. Examination of the activities of 43 chemotherapeutic agents against Neospora caninum tachyzoites in cultured cells. American Journal of Veterinary Research. 55: 976-81. PMID 7978638  0.88
1994 Dykstra CC, McClernon DR, Elwell LP, Tidwell RR. Selective inhibition of topoisomerases from Pneumocystis carinii compared with that of topoisomerases from mammalian cells Antimicrobial Agents and Chemotherapy. 38: 1890-1898. PMID 7810995  0.88
1994 Donkor IO, Tidwell RR, Jones SK. Pentamidine congeners. 2. 2-butene-bridged aromatic diamidines and diimidazolines as potential anti-pneumocystis carinii pneumonia agents Journal of Medicinal Chemistry®. 37: 4554-4557. PMID 7799405  0.88
1993 Donkor IO, Jones SK, Tidwell RR. Pentamidine Congeners 1: Synthesis of Cis- and Trans-Butamidine Analogues As Anti-Pneumocystis carinii Pneumonia Agents. Bioorganic & Medicinal Chemistry Letters. 3: 1137-1140. PMID 21451734 DOI: 10.1016/S0960-894X(00)80302-9  0.88
1993 Fairley TA, Tidwell RR, Donkor I, Naiman NA, Ohemeng KA, Lombardy RJ, Bentley JA, Cory M. Structure, DNA minor groove binding, and base pair specificity of alkyl- and aryl-linked bis(amidinobenzimidazoles) and bis(amidinoindoles) Journal of Medicinal Chemistry. 36: 1746-1753. PMID 8510102  0.88
1993 Dieter Geratz J, Pryzwansky KB, Schwab JH, Anderle SK, Tidwell RR. Suppression of local and systemic responses in streptococcal cell wall-induced acute inflammation of the air pouch by cyclosporine A. Comparison with the effects of two anti-inflammatory bis-benzimidazoles. The American Journal of Pathology. 142: 1227-37. PMID 8475995  0.88
1993 Caughey GH, Raymond WW, Bacci E, Lombardy RJ, Tidwell RR. Bis(5-amidino-2-benzimidazolyl)methane and related amidines are potent, reversible inhibitors of mast cell tryptases. The Journal of Pharmacology and Experimental Therapeutics. 264: 676-82. PMID 8437115  0.88
1993 Fletcher LD, Berger LC, Peel SA, Baric RS, Tidwell RR, Dykstra CC. Isolation and identification of six Pneumocystis carinii genes utilizing codon bias Gene. 129: 167-174. PMID 8325503 DOI: 10.1016/0378-1119(93)90265-5  0.88
1993 Jones HE, Blundell GK, Tidwell RR, Hall JE, Farr SJ, Richards RJ. The accumulation of pentamidine and the toxic effects of the drug, its selected analogues and metabolites on isolated alveolar cells Toxicology. 80: 1-12. PMID 8322368 DOI: 10.1016/0300-483X(93)90072-Z  0.88
1993 Tidwell RR, Jones SK, Naiman NA, Berger LC, Brake WB, Dykstra CC, Hall JE. Activity of cationically substituted bis-benzimidazoles against experimental Pneumocystis carinii pneumonia. Antimicrobial Agents and Chemotherapy. 37: 1713-6. PMID 8215291  0.88
1993 Hanson GD, Slattum P, Tidwell RR, Bekersky I, Mong S. Determination of 1,3-di(4-imidazolino-2-methoxyphenoxy)propane in rat, dog and human plasma and urine by high-performance liquid chromatography with fluorescence detection Journal of Chromatography B: Biomedical Sciences and Applications. 622: 61-69. PMID 8120114 DOI: 10.1016/0378-4347(93)80250-8  0.88
1993 Bell CA, Dykstra CC, Naiman NA, Cory M, Fairley TA, Tidwell RR. Structure-activity studies of dicationically substituted bis-benzimidazoles against Giardia lamblia: correlation of antigiardial activity with DNA binding affinity and giardial topoisomerase II inhibition. Antimicrobial Agents and Chemotherapy. 37: 2668-73. PMID 8109934  0.88
1993 Fletcher LD, Berger LC, Tidwell RR, Dykstra CC. Cloning and characterization of the calmodulin-encoding gene from Pneumocystis carinii Gene. 129: 307-308. PMID 7916711 DOI: 10.1016/0378-1119(93)90285-B  0.88
1992 Cory M, Tidwell RR, Fairley TA. Structure and DNA binding activity of analogues of 1,5-bis(4-amidinophenoxy)pentane (pentamidine) Journal of Medicinal Chemistry. 35: 431-438. PMID 1738139  0.88
1992 Berger BJ, Henry L, Hall JE, Tidwell RR. Problems and Pitfalls in the Assay of Pentamidine: Implications for Clinical Use Clinical Pharmacokinetics. 22: 163-168. PMID 1559310 DOI: 10.2165/00003088-199222030-00001  0.88
1992 Corsini E, Dykstra C, Craig WA, Tidwell RR, Rosenthal GJ. Pneumocystis carinii induction of tumor necrosis factor-α by alveolar macrophages: modulation by pentamidine isethionate Immunology Letters. 34: 303-308. PMID 1487315 DOI: 10.1016/0165-2478(92)90228-G  0.88
1992 Berger BJ, Naiman NA, Hall JE, Peggins J, Brewer TG, Tidwell RR. Primary and secondary metabolism of pentamidine by rats Antimicrobial Agents and Chemotherapy. 36: 1825-1831. PMID 1416874  0.88
1992 Geratz JD, Tidwell RR. BBE Drugs of the Future. 17: 371-373.  0.88
1991 Bartlett MS, Queener SF, Tidwell RR, Milhous WK, Berman JD, Ellis WY, Smith JW. 8-Aminoquinolines from Walter Reed Army Institute for Research for treatment and prophylaxis of Pneumocystis pneumonia in rat models. Antimicrobial Agents and Chemotherapy. 35: 277-82. PMID 2024961  0.88
1991 Berger BJ, Reddy VV, Le ST, Lombardy RJ, Hall JE, Tidwell RR. Hydroxylation of pentamidine by rat liver microsomes Journal of Pharmacology and Experimental Therapeutics. 256: 883-889. PMID 2005586  0.88
1991 Lindsay DS, Blagburn BL, Hall JE, Tidwell RR. Activity of pentamidine and pentamidine analogs against Toxoplasma gondii in cell cultures Antimicrobial Agents and Chemotherapy. 35: 1914-1916. PMID 1952867  0.88
1991 Blagburn BL, Sundermann CA, Lindsay DS, Hall JE, Tidwell RR. Inhibition of Cryptosporidium parvum in neonatal Hsd:(ICR)BR Swiss mice by polyether ionophores and aromatic amidines Antimicrobial Agents and Chemotherapy. 35: 1520-1523. PMID 1929322  0.88
1991 Bell CA, Cory M, Fairley TA, Hall JE, Tidwell RR. Structure-activity relationships of pentamidine analogs against Giardia lamblia and correlation of antigiardial activity with DNA-binding affinity. Antimicrobial Agents and Chemotherapy. 35: 1099-107. PMID 1929249  0.88
1991 Geratz JD, Tidwell RR, Lombardy RJ, Schwab JH, Anderle SK, Pryzwansky KB. Streptococcal cell wall-induced systemic disease. Beneficial effects of trans-bis(5-amidino-2-benzimidazolyl)ethene, a novel, macrophage-directed anti-inflammatory agent. The American Journal of Pathology. 139: 921-31. PMID 1928307  0.88
1991 Dykstra CC, Blagburn BL, Tidwell RR. Construction of genomic libraries of Cryptosporidium parvum and identification of antigen-encoding genes Journal of Protozoology. 38. PMID 1818217  0.88
1991 Tidwell RR, Jones SK, Dykstra CC, Gorton L, Hall JE. Treatment of experimental Pneumocystis carinii pneumonia with 1,3-di(4-imidazolino-2-methoxyphenoxy)propane lactate Journal of Protozoology. 38. PMID 1818146  0.88
1991 Dykstra CC, Tidwell RR. Inhibition of topoisomerases from Pneumocystis carinii by aromatic dicationic molecules Journal of Protozoology. 38. PMID 1667935  0.88
1990 Jones SK, Hall JE, Allen MA, Morrison SD, Ohemeng KA, Reddy VV, Geratz JD, Tidwell RR. Novel pentamidine analogs in the treatment of experimental Pneumocystis carinii pneumonia. Antimicrobial Agents and Chemotherapy. 34: 1026-30. PMID 2393262  0.88
1990 Berger BJ, Hall JE, Tidwell RR. The distribution of multiple doses of pentamidine in rats Pharmacology and Toxicology. 66: 234-236. PMID 2333279  0.88
1990 Geratz JD, Tidwell RR, Schwab JH, Anderle SK, Pryzwansky KB. Sequential events in the pathogenesis of streptococcal cell wall-induced arthritis and their modulation by bis(5-amidino-2-benzimidazolyl)methane (BABIM). The American Journal of Pathology. 136: 909-21. PMID 2327474  0.88
1990 Tidwell RR, Jones SK, Dieter Geratz J, Ohemeng KA, Cory M, Hall JE. Analogues of 1,5-bis(4-amidinophenoxy)pentane (pentamidine) in the treatment of experimental Pneumocystis carinii pneumonia Journal of Medicinal Chemistry. 33: 1252-1257. PMID 2319567  0.88
1990 Berger BJ, Lombardy RJ, Marbury GD, Bell CA, Dykstra CC, Hall JE, Tidwell RR. Metabolic N-hydroxylation of pentamidine in vitro. Antimicrobial Agents and Chemotherapy. 34: 1678-84. PMID 2285279  0.88
1990 Bell CA, Hall JE, Kyle DE, Grogl M, Ohemeng KA, Allen MA, Tidwell RR. Structure-activity relationships of analogs of pentamidine against Plasmodium falciparum and Leishmania mexicana amazonensis. Antimicrobial Agents and Chemotherapy. 34: 1381-6. PMID 2201254  0.88
1990 Tidwell RR, Jones SK, Geratz JD, Ohemeng KA, Bell CA, Berger BJ, Hall JE. Development of pentamidine analogues as new agents for the treatment of Pneumocystis carinii pneumonia. Annals of the New York Academy of Sciences. 616: 421-41. PMID 2078033  0.88
1989 Tidwell RR, Kilgore SG, Ohemeng KA, Geratz JD, Hall JE. Treatment of experimental Pneumocystis carinii pneumonia with analogs of pentamidine Journal of Protozoology. 36. PMID 2785206  0.88
1989 Berger BJ, Hall JE, Tidwell RR. High-performance liquid chromatographic method for the quantification of several diamidine compounds with potential chemotherapeutic value Journal of Chromatography B: Biomedical Sciences and Applications. 494: 191-200. PMID 2584316 DOI: 10.1016/S0378-4347(00)82668-7  0.88
1988 Geratz JD, Pryzwansky KB, Schwab JH, Anderle SK, Tidwell RR. Suppression of streptococcal cell wall-induced arthritis by a potent protease inhibitor, bis(5-amidino-2-benzimidazolyl)methane. Arthritis and Rheumatism. 31: 1156-64. PMID 3048276  0.88
1988 Vonderfecht SL, Miskuff RL, Wee SB, Sato S, Tidwell RR, Geratz JD, Yolken RH. Protease inhibitors suppress the in vitro and in vivo replication of rotavirus Journal of Clinical Investigation. 82: 2011-2016. PMID 2848866  0.88
1987 Jennette JC, Tidwell RR, Geratz JD, Bing DH, Falk RJ. Amelioration of immune complex-mediated glomerulonephritis by synthetic protease inhibitors American Journal of Pathology. 127: 499-506. PMID 2954467  0.88
1986 Cresson DH, Beckman WC, Tidwell RR, Geratz JD, Siegal GP. In vitro inhibition of human sarcoma cells invasive ability by bis(5-amidino-2-benzimidazolyl)methane: A novel esteroprotease inhibitor American Journal of Pathology. 123: 46-56. PMID 3008561  0.88
1984 Walker DH, Tidwell RR, Rector TM, Geratz JD. Effects of synthetic protease inhibitors of the amidine type on cell injury by Rickettsia rickettsii Antimicrobial Agents and Chemotherapy. 25: 582-585. PMID 6428311  0.88
1984 Tidwell RR, Geratz JD, Clyde WA, Rosenthal KU, Dubovi EJ. Suppression of respiratory syncytial virus infection in cotton rats by bis(5-amidino-2-benzimidazolyl)methane Antimicrobial Agents and Chemotherapy. 26: 591-593. PMID 6393863  0.88
1983 Dubovi EJ, Geratz JD, Tidwell RR. Enhancement of respiratory syncytial virus-induced cytopathology by trypsin, thrombin, and plasmin Infection and Immunity. 40: 351-358. PMID 6219957  0.88
1983 Tidwell RR, Geratz JD, Dubovi EJ. Aromatic amidines: Comparison of their ability to block respiratory syncytial virus induced cell fusion and to inhibit plasmin, urokinase, thrombin, and trypsin Journal of Medicinal Chemistry. 26: 294-298. PMID 6219223  0.88
1981 Dubovi EJ, Geratz JD, Shaver SR, Tidwell RR. Inhibition of respiratory syncytial virus-host cell interactions by mono- and diamidines Antimicrobial Agents and Chemotherapy. 19: 649-656. PMID 7247387  0.88
1981 Geratz JD, Shaver SR, Tidwell RR. Inhibitory effect of amidino-substituted heterocyclic compounds on the amidase activity of plasmin and of high and low molecular weight urokinase and on urokinase-induced plasminogen activation Thrombosis Research. 24: 73-83. PMID 6460342 DOI: 10.1016/0049-3848(81)90033-5  0.88
1981 Geratz JD, Shaver SR, Tidwell RR. Characterization of the active site of urokinase with a series of potent inhibitory amidines Thrombosis and Haemostasis. 46.  0.88
1980 Tidwell RR, Webster WP, Shaver SR, Geratz JD. Strategies for anticoagulation with synthetic protease inhibitors. Xa inhibitors versus thrombin inhibitors. Thrombosis Research. 19: 339-49. PMID 7434318  0.88
1980 Dubovi EJ, Geratz JD, Tidwell RR. Inhibition of respiratory syncytial virus by bis(5-amidino-2-benzimidazolyl)methane Virology. 103: 502-504. PMID 6247826 DOI: 10.1016/0042-6822(80)90207-X  0.88
1980 Tidwell RR, Geratz JD. Anticoagulation with synthetic factor Xa inhibitors Circulation. 62.  0.88
1979 Geratz JD, Stevens FM, Polakoski KL, Parrish RF, Tidwell RR. Amidino-substituted aromatic heterocycles as probes of the specificity pocket of trypsin-like proteases Archives of Biochemistry and Biophysics. 197: 551-559. PMID 41488 DOI: 10.1016/0003-9861(79)90279-0  0.88
1979 Tidwell RR, Geratz JD. Amidino-substituted heterocycles as probes of the specificity pocket of proteases involved in coagulation and fibrinolysis Thrombosis and Haemostasis. 42: 204.  0.88
1978 Parrish RF, Straus JW, Paulson JD, Polakoski KL, Tidwell RR, Geratz JD, Stevens FM. Structure-activity relationships for the inhibition of acrosin by benzamidine derivatives. Journal of Medicinal Chemistry. 21: 1132-6. PMID 722718  0.88
1978 Tidwell RR, Geratz JD, Dann O, Volz D, Zeh G, Loewe H. Diarylamidine derivatives with one or both of the aryl moieties consisting of an indole or indole-like ring. Inhibitors of arginine-specific esteroproteases Journal of Medicinal Chemistry. 21: 613-623. PMID 671460  0.88
1978 Geratz JD, Tidwell RR, Brinkhous KM, Mohammad SF, Dann O, Loewe H. Specific inhibition of platelet agglutination and aggregation by aromatic amidino compounds Thrombosis and Haemostasis. 39: 411-425. PMID 580990  0.88
1978 Greatz JD, Tidwell RR. Current concepts on action of synthetic thrombin inhibitors Pathophysiology of Haemostasis and Thrombosis. 7: 170-176. PMID 350730 DOI: 10.1159/000214258  0.88
1978 Geretz JD, Tidwell RR. Differential inhibition of thrombin and factor Xa by novel synthetic inhibitors Federation Proceedings. 37.  0.88
1977 Geratz JD, Tidwell RR, Brinkhous KM, Mohammad SF. Selective inhibition of platelet agglutination and aggregation by aromatic amidino compounds Thrombosis and Haemostasis. 38: 94.  0.88
1976 Geratz JD, Cheng MCF, Tidwell RR. Novel bis(benzamidino) compounds with an aromatic central link. Inhibitors of thrombin, pancreatic kallikrein, trypsin, and complement Journal of Medicinal Chemistry. 19: 634-639. PMID 1271404  0.88
1976 Tidwell RR, Fox LL, Geratz JD. Aromatic Tris-amidines. A new class of highly active inhibitors of Trypsin-like proteases Bba - Enzymology. 445: 729-738. PMID 1086099 DOI: 10.1016/0005-2744(76)90123-6  0.88
1976 Mathison IW, Tidwell RR. An improved synthesis of 6-amino-1,2,3,4-tetrahydro-2-methylisoquinoline: Elucidation of the stereochemistry of some diastereoisomers of 6-amino-2-methyldecahydroisoquinoline Journal of the Chemical Society, Perkin Transactions 1. 757-762.  0.88
1975 Mathison IW, Tidwell RR. Structure-activity relationships of antiarrhythmic 6-substituted decahydroisoquinolines Journal of Medicinal Chemistry. 18: 1227-1231. PMID 1195276  0.88
1975 Geratz JD, Cheng MCF, Tidwell RR. New aromatic diamidines with central α-oxyalkane or α,ω-dioxyalkane chains. Structure-activity relationships for the inhibition of trypsin, pancreatic kallikrein,and thrombin and for the inhibition of the overall coagulation process Journal of Medicinal Chemistry. 18: 477-481. PMID 1171238  0.88
1973 Mathison IW, Fowler KC, Morgan PH, Tidwell RR, Peters ER, Wojciechowski NJ, Lawson JW, Hetzer FK. Synthesis and hypotensive properties of tetrahydroisoquinolines. Journal of Medicinal Chemistry. 16: 332-6. PMID 4716177  0.88
1972 Mathison IW, Morgan PH, Tidwell RR, Handorf CR. Steric and physicochemical studies of decahydroisoquinolines possessing antiarrhythmic activity Journal of Pharmaceutical Sciences. 61: 637-639. PMID 5014327  0.88
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