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Marcelo C. Sousa - Publications

Affiliations: 
University of Colorado, Boulder, Boulder, CO, United States 
Area:
Biochemistry, Medical Biophysics, General Biophysics, Microbiology Biology
Website:
https://www.colorado.edu/biochemistry/marcelo-c-sousa
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52 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2023 Lee Upton S, Tay JW, Schwartz DK, Sousa MC. Similarly slow diffusion of BAM and SecYEG complexes in live E. coli cells observed with 3D spt-PALM. Biophysical Journal. PMID 37853695 DOI: 10.1016/j.bpj.2023.10.017  0.307
2023 Muñoz-Escudero D, Breazeale SD, Lee M, Guan Z, Raetz CRH, Sousa MC. Structure and Function of ArnD. A Deformylase Essential for Lipid A Modification with 4-Amino-4-deoxy-l-arabinose and Polymyxin Resistance. Biochemistry. 62: 2970-2981. PMID 37782650 DOI: 10.1021/acs.biochem.3c00293  0.365
2023 Mitchell ME, Gatzeva-Topalova PZ, Bargmann AD, Sammakia T, Sousa MC. Targeting the Conformational Change in ArnA Dehydrogenase for Selective Inhibition of Polymyxin Resistance. Biochemistry. 62: 2216-2227. PMID 37410993 DOI: 10.1021/acs.biochem.3c00227  0.807
2020 Munoz D, Sousa MC. Biochemical and Structural Characterization of Enzymes Responsible of Polymyxin Resistance in Gram-Negative Bacteria Biophysical Journal. 118. DOI: 10.1016/J.Bpj.2019.11.2887  0.354
2020 DaPron KE, Fink M, LeBlanc M, Edwards DT, Perkins TT, Sousa MC. Investigation of Mechanically Labile Type III Secretion Protein Effectors Biophysical Journal. 118: 509a. DOI: 10.1016/J.Bpj.2019.11.2802  0.301
2019 Hjortness MK, Riccardi L, Hongdusit A, Ruppe A, Zhao M, Kim EY, Zwart PH, Sankaran B, Arthanari H, Sousa MC, De Vivo M, Fox JM. Correction to "Abietane-Type Diterpenoids Inhibit Protein Tyrosine Phosphatases by Stabilizing an Inactive Enzyme Conformation". Biochemistry. PMID 31181901 DOI: 10.1021/Acs.Biochem.9B00423  0.357
2019 Mitchell M, Sousa M. Developing a Single-Molecule Platform to Understand Outer Membrane Protein Biogenesis Biophysical Journal. 116. DOI: 10.1016/J.Bpj.2018.11.2682  0.341
2018 Hjortness MK, Riccardi L, Hongdusit A, Ruppe A, Zhao M, Kim EY, Zwart PH, Sankaran B, Arthanari H, Sousa MC, De Vivo M, Fox JM. Abietane-Type Diterpenoids Inhibit Protein Tyrosine Phosphatases by Stabilizing an Inactive Enzyme Conformation. Biochemistry. PMID 30169954 DOI: 10.1021/Acs.Biochem.8B00655  0.418
2017 Walder R, LeBlanc MA, Van Patten WJ, Edwards D, Greenberg JA, Adhikari A, Okoniewski SR, Sullan RMA, Rabuka D, Sousa MC, Perkins TT. Rapid Characterization of a Mechanically Labile α-helical Protein Enabled by Efficient Site-Specific Bioconjugation. Journal of the American Chemical Society. PMID 28677396 DOI: 10.1021/Jacs.7B02958  0.349
2017 Doerner PA, Sousa MC. Extreme Dynamics in the BamA β-Barrel Seam. Biochemistry. PMID 28569500 DOI: 10.1021/Acs.Biochem.7B00281  0.397
2017 LeBlanc M, Edwards DT, Walder R, Rabuka D, Perkins TT, Sousa MC. Heterobifunctional Polyprotein for Efficient Characterization of Mechanically Labile Proteins Biophysical Journal. 112: 455a-456a. DOI: 10.1016/J.Bpj.2016.11.2441  0.326
2017 Doerner PA, Sousa MC. In vitro Reconstitution to Understand the Mechanism of Bam Biophysical Journal. 112: 205a. DOI: 10.1016/J.Bpj.2016.11.1133  0.47
2016 Warner LR, Gatzeva-Topalova PZ, Doerner PA, Pardi A, Sousa MC. Flexibility in the Periplasmic Domain of BamA Is Important for Function. Structure (London, England : 1993). PMID 27989620 DOI: 10.1016/J.Str.2016.11.013  0.81
2016 Fleming PJ, Patel DS, Wu EL, Qi Y, Yeom MS, Sousa MC, Fleming KG, Im W. BamA POTRA Domain Interacts with a Native Lipid Membrane Surface. Biophysical Journal. 110: 2698-709. PMID 27332128 DOI: 10.1016/J.Bpj.2016.05.010  0.512
2016 Doerner PA, Sousa MC. Small Angle X-ray Scattering (SAXS) Characterization of the POTRA Domains of BamA. Methods in Molecular Biology (Clifton, N.J.). 1329: 149-55. PMID 26427682 DOI: 10.1007/978-1-4939-2871-2_11  0.322
2016 Doerner PA, Sousa MC. Small Angle X-ray Scattering (SAXS) Characterization of the POTRA Domains of BamA. Methods in Molecular Biology (Clifton, N.J.). 1329: 149-55. PMID 26427682 DOI: 10.1007/978-1-4939-2871-2_11  0.322
2015 Bergal HT, Hopkins AH, Metzner SI, Sousa MC. The Structure of a BamA-BamD Fusion Illuminates the Architecture of the β-Barrel Assembly Machine Core. Structure (London, England : 1993). PMID 26749448 DOI: 10.1016/J.Str.2015.10.030  0.55
2015 Nordwald EM, Plaks JG, Snell JR, Sousa MC, Kaar JL. Crystallographic Investigation of Imidazolium Ionic Liquid Effects on Enzyme Structure. Chembiochem : a European Journal of Chemical Biology. 16: 2456-9. PMID 26388426 DOI: 10.1002/Cbic.201500398  0.3
2015 Jansen KB, Baker SL, Sousa MC. Crystal structure of BamB bound to a periplasmic domain fragment of BamA, the central component of the β-barrel assembly machine. The Journal of Biological Chemistry. 290: 2126-36. PMID 25468906 DOI: 10.1074/Jbc.M114.584524  0.804
2014 Turco MM, Sousa MC. The structure and specificity of the type III secretion system effector NleC suggest a DNA mimicry mechanism of substrate recognition. Biochemistry. 53: 5131-9. PMID 25040221 DOI: 10.1021/Bi500593E  0.782
2014 Lee M, Sousa MC. Structural basis for substrate specificity in ArnB. A key enzyme in the polymyxin resistance pathway of Gram-negative bacteria. Biochemistry. 53: 796-805. PMID 24460375 DOI: 10.1021/Bi4015677  0.476
2014 Sousa MC. Structure and Function of the Beta-Barrel Assembly Machine and its Associated Chaperones Biophysical Journal. 106. DOI: 10.1016/J.Bpj.2013.11.1562  0.485
2013 Templeton PD, Litman ES, Metzner SI, Ahn NG, Sousa MC. Structure of mediator of RhoA-dependent invasion (MRDI) explains its dual function as a metabolic enzyme and a mediator of cell invasion. Biochemistry. 52: 5675-84. PMID 23859498 DOI: 10.1021/Bi400556E  0.633
2013 Turco MM, Sousa MC. Structural and Biochemical Characterization of a New Zincin Protease, NleC, an Enteropathogenic Escherichia Coli Type III Secretion System Effector Responsible for Cleaving NFκB Subunit Rela Biophysical Journal. 104: 547a-548a. DOI: 10.1016/J.Bpj.2012.11.3035  0.775
2012 Jansen KB, Baker SL, Sousa MC. Crystal structure of BamB from Pseudomonas aeruginosa and functional evaluation of its conserved structural features. Plos One. 7: e49749. PMID 23189157 DOI: 10.1371/Journal.Pone.0049749  0.813
2011 Warner LR, Varga K, Lange OF, Baker SL, Baker D, Sousa MC, Pardi A. Structure of the BamC two-domain protein obtained by Rosetta with a limited NMR data set. Journal of Molecular Biology. 411: 83-95. PMID 21624375 DOI: 10.1016/J.Jmb.2011.05.022  0.504
2011 Sandoval CM, Baker SL, Jansen K, Metzner SI, Sousa MC. Crystal structure of BamD: an essential component of the β-Barrel assembly machinery of gram-negative bacteria. Journal of Molecular Biology. 409: 348-57. PMID 21463635 DOI: 10.1016/J.Jmb.2011.03.035  0.799
2010 Gatzeva-Topalova PZ, Warner LR, Pardi A, Sousa MC. Structure and flexibility of the complete periplasmic domain of BamA: the protein insertion machine of the outer membrane. Structure (London, England : 1993). 18: 1492-501. PMID 21070948 DOI: 10.1016/J.Str.2010.08.012  0.827
2010 Orban T, Bereta G, Miyagi M, Wang B, Chance MR, Sousa MC, Palczewski K. Conformational changes in guanylate cyclase-activating protein 1 induced by Ca2+ and N-terminal fatty acid acylation. Structure (London, England : 1993). 18: 116-26. PMID 20152158 DOI: 10.1016/J.Str.2009.11.008  0.447
2009 Kabuyama Y, Litman ES, Templeton PD, Metzner SI, Witze ES, Argast GM, Langer SJ, Polvinen K, Shellman Y, Chan D, Shabb JB, Fitzpatrick JE, Resing KA, Sousa MC, Ahn NG. A mediator of Rho-dependent invasion moonlights as a methionine salvage enzyme. Molecular & Cellular Proteomics : McP. 8: 2308-20. PMID 19620624 DOI: 10.1074/Mcp.M900178-Mcp200  0.608
2009 Walton TA, Sandoval CM, Fowler CA, Pardi A, Sousa MC. The cavity-chaperone Skp protects its substrate from aggregation but allows independent folding of substrate domains. Proceedings of the National Academy of Sciences of the United States of America. 106: 1772-7. PMID 19181847 DOI: 10.1073/Pnas.0809275106  0.809
2008 Gatzeva-Topalova PZ, Walton TA, Sousa MC. Crystal structure of YaeT: conformational flexibility and substrate recognition. Structure (London, England : 1993). 16: 1873-81. PMID 19081063 DOI: 10.1016/J.Str.2008.09.014  0.813
2008 Stephen R, Filipek S, Palczewski K, Sousa MC. Ca 2+-dependent Regulation of Phototransduction Photochemistry and Photobiology. 84: 903-910. PMID 18346093 DOI: 10.1111/J.1751-1097.2008.00323.X  0.769
2008 Kline T, Trent MS, Stead CM, Lee MS, Sousa MC, Felise HB, Nguyen HV, Miller SI. Synthesis of and evaluation of lipid A modification by 4-substituted 4-deoxy arabinose analogs as potential inhibitors of bacterial polymyxin resistance. Bioorganic & Medicinal Chemistry Letters. 18: 1507-10. PMID 18187325 DOI: 10.1016/J.Bmcl.2007.12.061  0.304
2007 Stephen R, Bereta G, Golczak M, Palczewski K, Sousa MC. Stabilizing Function for Myristoyl Group Revealed by the Crystal Structure of a Neuronal Calcium Sensor, Guanylate Cyclase-Activating Protein 1 Structure. 15: 1392-1402. PMID 17997965 DOI: 10.1016/J.Str.2007.09.013  0.77
2006 Stephen R, Palczewski K, Sousa MC. The crystal structure of GCAP3 suggests molecular mechanism of GCAP-linked cone dystrophies. Journal of Molecular Biology. 359: 266-75. PMID 16626734 DOI: 10.1016/J.Jmb.2006.03.042  0.786
2005 Gatzeva-Topalova PZ, May AP, Sousa MC. Structure and mechanism of ArnA: conformational change implies ordered dehydrogenase mechanism in key enzyme for polymyxin resistance. Structure (London, England : 1993). 13: 929-42. PMID 15939024 DOI: 10.1016/J.Str.2005.03.018  0.818
2005 Gatzeva-Topalova PZ, May AP, Sousa MC. Crystal structure and mechanism of the Escherichia coli ArnA (PmrI) transformylase domain. An enzyme for lipid A modification with 4-amino-4-deoxy-L-arabinose and polymyxin resistance. Biochemistry. 44: 5328-38. PMID 15807526 DOI: 10.1021/Bi047384G  0.818
2004 Gatzeva-Topalova PZ, May AP, Sousa MC. Crystal structure of Escherichia coli ArnA (PmrI) decarboxylase domain. A key enzyme for lipid A modification with 4-amino-4-deoxy-L-arabinose and polymyxin resistance. Biochemistry. 43: 13370-9. PMID 15491143 DOI: 10.1021/Bi048551F  0.813
2004 Walton TA, Sousa MC. Crystal structure of Skp, a prefoldin-like chaperone that protects soluble and membrane proteins from aggregation. Molecular Cell. 15: 367-74. PMID 15304217 DOI: 10.1016/J.Molcel.2004.07.023  0.803
2003 Ridge KD, Abdulaev NG, Sousa M, Palczewski K. Phototransduction: Crystal clear Trends in Biochemical Sciences. 28: 479-487. PMID 13678959 DOI: 10.1016/S0968-0004(03)00172-5  0.386
2003 Ridge KD, Abdulaev NG, Sousa M, Palczewski K. Erratum to: “Phototransduction: crystal clear”[Trends Biochem. Sci. 28 (2003) 479–487] Trends in Biochemical Sciences. 28: 526. DOI: 10.1016/J.Tibs.2003.08.008  0.33
2002 Sousa MC, Kessler BM, Overkleeft HS, McKay DB. Crystal structure of HslUV complexed with a vinyl sulfone inhibitor: corroboration of a proposed mechanism of allosteric activation of HslV by HslU. Journal of Molecular Biology. 318: 779-85. PMID 12054822 DOI: 10.1016/S0022-2836(02)00145-6  0.623
2001 Sousa MC, McKay DB. Structure of the universal stress protein of Haemophilus influenzae. Structure (London, England : 1993). 9: 1135-41. PMID 11738040 DOI: 10.1016/S0969-2126(01)00680-3  0.639
2001 Sousa MC, McKay DB. Structure of Haemophilus influenzae HslV protein at 1.9 A resolution, revealing a cation-binding site near the catalytic site. Acta Crystallographica. Section D, Biological Crystallography. 57: 1950-4. PMID 11717526 DOI: 10.1107/S090744490101575X  0.611
2000 Sousa MC, Trame CB, Tsuruta H, Wilbanks SM, Reddy VS, McKay DB. Crystal and solution structures of an HslUV protease-chaperone complex. Cell. 103: 633-43. PMID 11106733 DOI: 10.1016/S0092-8674(00)00166-5  0.66
1998 Sousa MC, McKay DB. The hydroxyl of threonine 13 of the bovine 70-kDa heat shock cognate protein is essential for transducing the ATP-induced conformational change. Biochemistry. 37: 15392-9. PMID 9799500 DOI: 10.1021/Bi981510X  0.634
1997 Ha JH, Hellman U, Johnson ER, Li L, McKay DB, Sousa MC, Takeda S, Wernstedt C, Wilbanks SM. Destabilization of peptide binding and interdomain communication by an E543K mutation in the bovine 70-kDa heat shock cognate protein, a molecular chaperone Journal of Biological Chemistry. 272: 27796-27803. PMID 9346924 DOI: 10.1074/Jbc.272.44.27796  0.603
1997 Sousa MC, McKay DB. Structural and functional studies of the bovine 70 kda heat shock protein Protein Engineering. 10: 36.  0.506
1996 Sousa MC, Parodi AJ. The interaction of the UDP-GLC:glycoprotein glucosyltransferase with the acceptor glycoprotein. Cellular and Molecular Biology (Noisy-Le-Grand, France). 42: 609-616. PMID 8832090  0.335
1993 Pollevick GD, Sanchez DO, Campetella O, Trombetta S, Sousa M, Henriksson J, Hellman U, Pettersson U, Cazzulo JJ, Frasch ACC. Members of the SAPA/trans-sialidase protein family have identical N-terminal sequences and a putative signal peptide Molecular and Biochemical Parasitology. 59: 171-174. PMID 8515779 DOI: 10.1016/0166-6851(93)90018-S  0.334
1992 Sousa MC, Ferrero-Garcia MA, Parodi AJ. Recognition of the oligosaccharide and protein moieties of glycoproteins by the UDP-Glc:Glycoprotein glucosyltransferase Biochemistry. 31: 97-105. PMID 1531024 DOI: 10.1021/Bi00116A015  0.383
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