Kim Lewis - Publications

Affiliations: 
Tufts University, Boston 
Area:
Microbiology Biology

81 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any innacuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2018 Cameron DR, Shan Y, Zalis EA, Isabella V, Lewis K. A genetic determinant of persister cell formation in bacterial pathogens. Journal of Bacteriology. PMID 29941425 DOI: 10.1128/JB.00303-18  0.48
2017 Zhou Q, Yamada A, Feng Q, Hoskins A, Dunietz BD, Lewis KM. Modification of molecular conductance by in-situ deprotection of thiol-based porphyrin. Acs Applied Materials & Interfaces. PMID 28332399 DOI: 10.1021/acsami.6b14841  0.36
2017 Lewis K, Shan Y. Why tolerance invites resistance. Science (New York, N.Y.). 355: 796. PMID 28232537 DOI: 10.1126/science.aam7926  0.48
2017 Shan Y, Brown Gandt A, Rowe SE, Deisinger JP, Conlon BP, Lewis K. ATP-Dependent Persister Formation in Escherichia coli. Mbio. 8. PMID 28174313 DOI: 10.1128/mBio.02267-16  0.48
2016 Jones MB, Nierman WC, Shan Y, Frank BC, Spoering A, Ling L, Peoples A, Zullo A, Lewis K, Nelson KE. Reducing the Bottleneck in Discovery of Novel Antibiotics. Microbial Ecology. PMID 27896376 DOI: 10.1007/s00248-016-0889-3  0.48
2016 Lewis K, Shan Y. Persister Awakening. Molecular Cell. 63: 3-4. PMID 27392143 DOI: 10.1016/j.molcel.2016.06.025  0.48
2016 Torrey HL, Keren I, Via LE, Lee JS, Lewis K. High Persister Mutants in Mycobacterium tuberculosis. Plos One. 11: e0155127. PMID 27176494 DOI: 10.1371/journal.pone.0155127  0.64
2016 Rowe SE, Conlon BP, Keren I, Lewis K. Persisters: Methods for Isolation and Identifying Contributing Factors-A Review. Methods in Molecular Biology (Clifton, N.J.). 1333: 17-28. PMID 26468096 DOI: 10.1007/978-1-4939-2854-5_2  0.48
2015 Dolla NK, Chen C, Larkins-Ford J, Rajamuthiah R, Jagadeesan S, Conery AL, Ausubel FM, Mylonakis E, Bremner JB, Lewis K, Kelso MJ. On the Mechanism of Berberine-INF55 (5-Nitro-2-phenylindole) Hybrid Antibacterials. Australian Journal of Chemistry. 67: 1471-1480. PMID 26806960 DOI: 10.1071/CH14426  0.48
2015 Schumacher MA, Balani P, Min J, Chinnam NB, Hansen S, Vulić M, Lewis K, Brennan RG. HipBA-promoter structures reveal the basis of heritable multidrug tolerance. Nature. 524: 59-64. PMID 26222023 DOI: 10.1038/nature14662  0.48
2015 Sharma B, Brown AV, Matluck NE, Hu LT, Lewis K. Borrelia burgdorferi, the Causative Agent of Lyme Disease, Forms Drug-Tolerant Persister Cells. Antimicrobial Agents and Chemotherapy. 59: 4616-24. PMID 26014929 DOI: 10.1128/AAC.00864-15  0.48
2015 Shan Y, Lazinski D, Rowe S, Camilli A, Lewis K. Genetic basis of persister tolerance to aminoglycosides in Escherichia coli. Mbio. 6. PMID 25852159 DOI: 10.1128/mBio.00078-15  0.48
2015 Ling LL, Schneider T, Peoples AJ, Spoering AL, Engels I, Conlon BP, Mueller A, Schäberle TF, Hughes DE, Epstein S, Jones M, Lazarides L, Steadman VA, Cohen DR, Felix CR, ... ... Lewis K, et al. Erratum: A new antibiotic kills pathogens without detectable resistance. Nature. 520: 388. PMID 25731174 DOI: 10.1038/nature14303  0.48
2015 Ling LL, Schneider T, Peoples AJ, Spoering AL, Engels I, Conlon BP, Mueller A, Schäberle TF, Hughes DE, Epstein S, Jones M, Lazarides L, Steadman VA, Cohen DR, Felix CR, ... ... Lewis K, et al. A new antibiotic kills pathogens without detectable resistance. Nature. 517: 455-9. PMID 25561178 DOI: 10.1038/nature14098  0.48
2015 Lewis K. Challenges of antibiotic discovery: Antibiotic resistance and tolerance plus troubles with discovery platforms complicate efforts to identify useful antibacterial drug candidates Microbe. 10: 363-369.  0.48
2014 Gavrish E, Shrestha B, Chen C, Lister I, North EJ, Yang L, Lee RE, Han A, Williams B, Charnuska D, Coleman K, Lewis K, LaFleur MD. In vitro and in vivo activities of HPi1, a selective antimicrobial against Helicobacter pylori. Antimicrobial Agents and Chemotherapy. 58: 3255-60. PMID 24687512 DOI: 10.1128/AAC.02573-13  0.48
2014 Gavrish E, Sit CS, Cao S, Kandror O, Spoering A, Peoples A, Ling L, Fetterman A, Hughes D, Bissell A, Torrey H, Akopian T, Mueller A, Epstein S, Goldberg A, ... ... Lewis K, et al. Lassomycin, a ribosomally synthesized cyclic peptide, kills mycobacterium tuberculosis by targeting the ATP-dependent protease ClpC1P1P2. Chemistry & Biology. 21: 509-18. PMID 24684906 DOI: 10.1016/j.chembiol.2014.01.014  0.48
2014 Chen C, Dolla NK, Casadei G, Bremner JB, Lewis K, Kelso MJ. Diarylacylhydrazones: Clostridium-selective antibacterials with activity against stationary-phase cells. Bioorganic & Medicinal Chemistry Letters. 24: 595-600. PMID 24360560 DOI: 10.1016/j.bmcl.2013.12.015  0.48
2014 Fleck LE, North EJ, Lee RE, Mulcahy LR, Casadei G, Lewis K. A screen for and validation of prodrug antimicrobials. Antimicrobial Agents and Chemotherapy. 58: 1410-9. PMID 24342644 DOI: 10.1128/AAC.02136-13  0.48
2014 Mulcahy LR, Isabella VM, Lewis K. Pseudomonas aeruginosa biofilms in disease. Microbial Ecology. 68: 1-12. PMID 24096885 DOI: 10.1007/s00248-013-0297-x  0.52
2013 Theodore A, Lewis K, Vulic M. Tolerance of Escherichia coli to fluoroquinolone antibiotics depends on specific components of the SOS response pathway. Genetics. 195: 1265-76. PMID 24077306 DOI: 10.1534/genetics.113.152306  0.48
2013 Balaban NQ, Gerdes K, Lewis K, McKinney JD. A problem of persistence: still more questions than answers? Nature Reviews. Microbiology. 11: 587-91. PMID 24020075 DOI: 10.1038/nrmicro3076  0.48
2013 Lafleur MD, Sun L, Lister I, Keating J, Nantel A, Long L, Ghannoum M, North J, Lee RE, Coleman K, Dahl T, Lewis K. Potentiation of azole antifungals by 2-adamantanamine. Antimicrobial Agents and Chemotherapy. 57: 3585-92. PMID 23689724 DOI: 10.1128/AAC.00294-13  0.48
2013 Lewis K. Platforms for antibiotic discovery. Nature Reviews. Drug Discovery. 12: 371-87. PMID 23629505 DOI: 10.1038/nrd3975  0.48
2013 Keren I, Wu Y, Inocencio J, Mulcahy LR, Lewis K. Killing by bactericidal antibiotics does not depend on reactive oxygen species. Science (New York, N.Y.). 339: 1213-6. PMID 23471410 DOI: 10.1126/science.1232688  0.64
2012 Lewis K. Persister cells: molecular mechanisms related to antibiotic tolerance. Handbook of Experimental Pharmacology. 121-33. PMID 23090599 DOI: 10.1007/978-3-642-28951-4_8  0.48
2012 Keren I, Mulcahy LR, Lewis K. Persister eradication: lessons from the world of natural products. Methods in Enzymology. 517: 387-406. PMID 23084949 DOI: 10.1016/B978-0-12-404634-4.00019-X  0.64
2012 Schumacher MA, Min J, Link TM, Guan Z, Xu W, Ahn YH, Soderblom EJ, Kurie JM, Evdokimov A, Moseley MA, Lewis K, Brennan RG. Role of unusual P loop ejection and autophosphorylation in HipA-mediated persistence and multidrug tolerance. Cell Reports. 2: 518-25. PMID 22999936 DOI: 10.1016/j.celrep.2012.08.013  0.48
2012 Lechner S, Lewis K, Bertram R. Staphylococcus aureus persisters tolerant to bactericidal antibiotics. Journal of Molecular Microbiology and Biotechnology. 22: 235-44. PMID 22986269 DOI: 10.1159/000342449  0.48
2012 Wu Y, Vulić M, Keren I, Lewis K. Role of oxidative stress in persister tolerance. Antimicrobial Agents and Chemotherapy. 56: 4922-6. PMID 22777047 DOI: 10.1128/AAC.00921-12  0.64
2012 Hansen S, Vulić M, Min J, Yen TJ, Schumacher MA, Brennan RG, Lewis K. Regulation of the Escherichia coli HipBA toxin-antitoxin system by proteolysis. Plos One. 7: e39185. PMID 22720069 DOI: 10.1371/journal.pone.0039185  0.48
2012 Lewis K. Antibiotics: Recover the lost art of drug discovery. Nature. 485: 439-40. PMID 22622552 DOI: 10.1038/485439a  0.48
2012 Lewis K. Drug tolerance, Persister cells and drug discovery Antimicrobial Drug Discovery: Emerging Strategies. 101-114.  0.48
2011 Keren I, Minami S, Rubin E, Lewis K. Characterization and transcriptome analysis of Mycobacterium tuberculosis persisters. Mbio. 2: e00100-11. PMID 21673191 DOI: 10.1128/mBio.00100-11  0.64
2011 Fiamegos YC, Kastritis PL, Exarchou V, Han H, Bonvin AM, Vervoort J, Lewis K, Hamblin MR, Tegos GP. Antimicrobial and efflux pump inhibitory activity of caffeoylquinic acids from Artemisia absinthium against gram-positive pathogenic bacteria. Plos One. 6: e18127. PMID 21483731 DOI: 10.1371/journal.pone.0018127  0.48
2011 LaFleur MD, Lucumi E, Napper AD, Diamond SL, Lewis K. Novel high-throughput screen against Candida albicans identifies antifungal potentiators and agents effective against biofilms. The Journal of Antimicrobial Chemotherapy. 66: 820-6. PMID 21393183 DOI: 10.1093/jac/dkq530  0.48
2010 Mulcahy LR, Burns JL, Lory S, Lewis K. Emergence of Pseudomonas aeruginosa strains producing high levels of persister cells in patients with cystic fibrosis. Journal of Bacteriology. 192: 6191-9. PMID 20935098 DOI: 10.1128/JB.01651-09  0.48
2010 Lewis K, Epstein S, D'Onofrio A, Ling LL. Uncultured microorganisms as a source of secondary metabolites. The Journal of Antibiotics. 63: 468-76. PMID 20648021 DOI: 10.1038/ja.2010.87  0.48
2010 Lewis K. Persister cells. Annual Review of Microbiology. 64: 357-72. PMID 20528688 DOI: 10.1146/annurev.micro.112408.134306  0.48
2010 Tomkiewicz D, Casadei G, Larkins-Ford J, Moy TI, Garner J, Bremner JB, Ausubel FM, Lewis K, Kelso MJ. Berberine-INF55 (5-nitro-2-phenylindole) hybrid antimicrobials: effects of varying the relative orientation of the berberine and INF55 components. Antimicrobial Agents and Chemotherapy. 54: 3219-24. PMID 20498327 DOI: 10.1128/AAC.01715-09  0.48
2010 D'Onofrio A, Crawford JM, Stewart EJ, Witt K, Gavrish E, Epstein S, Clardy J, Lewis K. Siderophores from neighboring organisms promote the growth of uncultured bacteria. Chemistry & Biology. 17: 254-64. PMID 20338517 DOI: 10.1016/j.chembiol.2010.02.010  0.48
2010 Dörr T, Vulić M, Lewis K. Ciprofloxacin causes persister formation by inducing the TisB toxin in Escherichia coli. Plos Biology. 8: e1000317. PMID 20186264 DOI: 10.1371/journal.pbio.1000317  0.48
2010 Lafleur MD, Qi Q, Lewis K. Patients with long-term oral carriage harbor high-persister mutants of Candida albicans. Antimicrobial Agents and Chemotherapy. 54: 39-44. PMID 19841146 DOI: 10.1128/AAC.00860-09  0.48
2010 Lewis K. Persister cells and the paradox of chronic infections Microbe. 5: 429-437.  0.48
2009 Dörr T, Lewis K, Vulić M. SOS response induces persistence to fluoroquinolones in Escherichia coli. Plos Genetics. 5: e1000760. PMID 20011100 DOI: 10.1371/journal.pgen.1000760  0.48
2009 Onnis-Hayden A, Weng H, He M, Hansen S, Ilyin V, Lewis K, Guc AZ. Prokaryotic real-time gene expression profiling for toxicity assessment. Environmental Science & Technology. 43: 4574-81. PMID 19603679 DOI: 10.1021/es803227z  0.48
2009 Moy TI, Conery AL, Larkins-Ford J, Wu G, Mazitschek R, Casadei G, Lewis K, Carpenter AE, Ausubel FM. High-throughput screen for novel antimicrobials using a whole animal infection model. Acs Chemical Biology. 4: 527-33. PMID 19572548 DOI: 10.1021/cb900084v  0.48
2009 Samosorn S, Tanwirat B, Muhamad N, Casadei G, Tomkiewicz D, Lewis K, Suksamrarn A, Prammananan T, Gornall KC, Beck JL, Bremner JB. Antibacterial activity of berberine-NorA pump inhibitor hybrids with a methylene ether linking group. Bioorganic & Medicinal Chemistry. 17: 3866-72. PMID 19419877 DOI: 10.1016/j.bmc.2009.04.028  0.48
2009 Schumacher MA, Piro KM, Xu W, Hansen S, Lewis K, Brennan RG. Molecular mechanisms of HipA-mediated multidrug tolerance and its neutralization by HipB. Science (New York, N.Y.). 323: 396-401. PMID 19150849 DOI: 10.1126/science.1163806  0.48
2008 Ambrus JI, Kelso MJ, Bremner JB, Ball AR, Casadei G, Lewis K. Structure-activity relationships of 2-aryl-1H-indole inhibitors of the NorA efflux pump in Staphylococcus aureus. Bioorganic & Medicinal Chemistry Letters. 18: 4294-7. PMID 18632270 DOI: 10.1016/j.bmcl.2008.06.093  0.48
2008 Hansen S, Lewis K, Vulić M. Role of global regulators and nucleotide metabolism in antibiotic tolerance in Escherichia coli. Antimicrobial Agents and Chemotherapy. 52: 2718-26. PMID 18519731 DOI: 10.1128/AAC.00144-08  0.48
2008 Lewis K. Multidrug tolerance of biofilms and persister cells Current Topics in Microbiology and Immunology. 322: 107-131. PMID 18453274 DOI: 10.1007/978-3-540-75418-3_6  0.48
2007 Lewis K. Persister cells, dormancy and infectious disease. Nature Reviews. Microbiology. 5: 48-56. PMID 17143318 DOI: 10.1038/nrmicro1557  0.48
2006 Ball AR, Casadei G, Samosorn S, Bremner JB, Ausubel FM, Moy TI, Lewis K. Conjugating berberine to a multidrug efflux pump inhibitor creates an effective antimicrobial. Acs Chemical Biology. 1: 594-600. PMID 17168555 DOI: 10.1021/cb600238x  0.48
2006 Lewis K, Ausubel FM. Prospects for plant-derived antibacterials. Nature Biotechnology. 24: 1504-7. PMID 17160050 DOI: 10.1038/nbt1206-1504  0.48
2006 Correia FF, D'Onofrio A, Rejtar T, Li L, Karger BL, Makarova K, Koonin EV, Lewis K. Kinase activity of overexpressed HipA is required for growth arrest and multidrug tolerance in Escherichia coli. Journal of Bacteriology. 188: 8360-7. PMID 17041039 DOI: 10.1128/JB.01237-06  0.48
2006 LaFleur MD, Kumamoto CA, Lewis K. Candida albicans biofilms produce antifungal-tolerant persister cells. Antimicrobial Agents and Chemotherapy. 50: 3839-46. PMID 16923951 DOI: 10.1128/AAC.00684-06  0.48
2006 Moy TI, Ball AR, Anklesaria Z, Casadei G, Lewis K, Ausubel FM. Identification of novel antimicrobials using a live-animal infection model. Proceedings of the National Academy of Sciences of the United States of America. 103: 10414-9. PMID 16801562 DOI: 10.1073/pnas.0604055103  0.48
2006 Belofsky G, Carreno R, Lewis K, Ball A, Casadei G, Tegos GP. Metabolites of the "smoke tree", Dalea spinosa, potentiate antibiotic activity against multidrug-resistant Staphylococcus aureus. Journal of Natural Products. 69: 261-4. PMID 16499327 DOI: 10.1021/np058057s  0.48
2006 Samosorn S, Bremner JB, Ball A, Lewis K. Synthesis of functionalized 2-aryl-5-nitro-1H-indoles and their activity as bacterial NorA efflux pump inhibitors. Bioorganic & Medicinal Chemistry. 14: 857-65. PMID 16203150 DOI: 10.1016/j.bmc.2005.09.019  0.48
2005 Lewis K, Klibanov AM. Surpassing nature: rational design of sterile-surface materials. Trends in Biotechnology. 23: 343-8. PMID 15922467 DOI: 10.1016/j.tibtech.2005.05.004  0.48
2005 Milović NM, Wang J, Lewis K, Klibanov AM. Immobilized N-alkylated polyethylenimine avidly kills bacteria by rupturing cell membranes with no resistance developed. Biotechnology and Bioengineering. 90: 715-22. PMID 15803464 DOI: 10.1002/bit.20454  0.48
2004 Gelman F, Lewis K, Klibanov AM. Drastically lowering the titer of waterborne bacteriophage PRD1 by exposure to immobilized hydrophobic polycations. Biotechnology Letters. 26: 1695-700. PMID 15604821 DOI: 10.1007/s10529-004-3737-3  0.48
2004 Keren I, Shah D, Spoering A, Kaldalu N, Lewis K. Specialized persister cells and the mechanism of multidrug tolerance in Escherichia coli. Journal of Bacteriology. 186: 8172-80. PMID 15576765 DOI: 10.1128/JB.186.24.8172-8180.2004  0.64
2004 Kaldalu N, Mei R, Lewis K. Killing by ampicillin and ofloxacin induces overlapping changes in Escherichia coli transcription profile. Antimicrobial Agents and Chemotherapy. 48: 890-6. PMID 14982780 DOI: 10.1128/AAC.48.3.890-896.2004  0.48
2004 Keren I, Kaldalu N, Spoering A, Wang Y, Lewis K. Persister cells and tolerance to antimicrobials. Fems Microbiology Letters. 230: 13-8. PMID 14734160  0.64
2003 Morel C, Stermitz FR, Tegos G, Lewis K. Isoflavones as potentiators of antibacterial activity. Journal of Agricultural and Food Chemistry. 51: 5677-9. PMID 12952418 DOI: 10.1021/jf0302714  0.48
2003 Lin J, Qiu S, Lewis K, Klibanov AM. Mechanism of bactericidal and fungicidal activities of textiles covalently modified with alkylated polyethylenimine. Biotechnology and Bioengineering. 83: 168-72. PMID 12768622 DOI: 10.1002/bit.10651  0.48
2003 Stermitz FR, Cashman KK, Halligan KM, Morel C, Tegos GP, Lewis K. Polyacylated neohesperidosides from Geranium caespitosum: bacterial multidrug resistance pump inhibitors. Bioorganic & Medicinal Chemistry Letters. 13: 1915-8. PMID 12749897 DOI: 10.1016/S0960-894X(03)00316-0  0.48
2002 Stermitz FR, Scriven LN, Tegos G, Lewis K. Two flavonols from Artemisa annua which potentiate the activity of berberine and norfloxacin against a resistant strain of Staphylococcus aureus. Planta Medica. 68: 1140-1. PMID 12494348 DOI: 10.1055/s-2002-36347  0.48
2002 Lin J, Qiu S, Lewis K, Klibanov AM. Bactericidal properties of flat surfaces and nanoparticles derivatized with alkylated polyethylenimines. Biotechnology Progress. 18: 1082-6. PMID 12363361 DOI: 10.1021/bp025597w  0.48
2002 Tegos G, Stermitz FR, Lomovskaya O, Lewis K. Multidrug pump inhibitors uncover remarkable activity of plant antimicrobials. Antimicrobial Agents and Chemotherapy. 46: 3133-41. PMID 12234835 DOI: 10.1128/AAC.46.10.3133-3141.2002  0.48
2002 Tiller JC, Lee SB, Lewis K, Klibanov AM. Polymer surfaces derivatized with poly(vinyl-N-hexylpyridinium) kill airborne and waterborne bacteria. Biotechnology and Bioengineering. 79: 465-71. PMID 12115410 DOI: 10.1002/bit.10299  0.48
2001 Lewis K. In search of natural substrates and inhibitors of MDR pumps Journal of Molecular Microbiology and Biotechnology. 3: 247-254. PMID 11321580  0.48
2001 Lewis K. Riddle of biofilm resistance Antimicrobial Agents and Chemotherapy. 45: 999-1007. PMID 11257008 DOI: 10.1128/AAC.45.4.999-1007.2001  0.48
2000 Lewis K. Translocases: A bacterial tunnel for drugs and proteins Current Biology. 10. PMID 10996810 DOI: 10.1016/S0960-9822(00)00682-5  0.48
2000 Lewis K. Programmed death in bacteria Microbiology and Molecular Biology Reviews. 64: 503-514. PMID 10974124  0.48
1999 Lewis K. Human longevity: An evolutionary approach Mechanisms of Ageing and Development. 109: 43-51. PMID 10405988 DOI: 10.1016/S0047-6374(99)00021-4  0.48
1999 Lewis K. Multidrug resistance: Versatile drug sensors of bacterial cells Current Biology. 9. PMID 10359693 DOI: 10.1016/S0960-9822(99)80254-1  0.48
1998 Lewis K. Pathogen resistance as the origin of kin altruism Journal of Theoretical Biology. 193: 359-363. PMID 9714935 DOI: 10.1006/jtbi.1998.0725  0.48
1994 Lewis K. Multidrug resistance pumps in bacteria: variations on a theme Trends in Biochemical Sciences. 19: 119-123. PMID 8203018 DOI: 10.1016/0968-0004(94)90204-6  0.48
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