Penelope Duerksen-Hughes - Publications

Affiliations: 
Loma Linda University, Loma Linda, United States 
Area:
Cell Biology, Microbiology Biology

75 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2020 Mirshahidi S, Shields TG, de Necochea-Campion R, Yuan X, Janjua A, Williams NL, Mirshahidi HR, Reeves ME, Duerksen-Hughes P, Zuckerman LM. Bupivacaine and Lidocaine Induce Apoptosis in Osteosarcoma Tumor Cells. Clinical Orthopaedics and Related Research. PMID 33009230 DOI: 10.1097/CORR.0000000000001510  0.4
2019 Mirshahidi S, de Necochea-Campion R, Moretta A, Williams NL, Reeves ME, Otoukesh S, Mirshahidi HR, Khosrowpour S, Duerksen-Hughes P, Zuckerman LM. Inhibitory Effects of Indomethacin in Human MNNG/HOS Osteosarcoma Cell Line . Cancer Investigation. 1-29. PMID 31770037 DOI: 10.1080/07357907.2019.1698592  0.4
2019 Katerji M, Filippova M, Duerksen-Hughes P. Approaches and Methods to Measure Oxidative Stress in Clinical Samples: Research Applications in the Cancer Field. Oxidative Medicine and Cellular Longevity. 2019: 1279250. PMID 30992736 DOI: 10.1155/2019/1279250  0.8
2016 Evans W, Filippova M, Filippov V, Bashkirova S, Zhang G, Reeves ME, Duerksen-Hughes P. Overexpression of HPV16 E6* Alters β-Integrin and Mitochondrial Dysfunction Pathways in Cervical Cancer Cells. Cancer Genomics & Proteomics. 13: 259-273. PMID 27365376  0.8
2016 Xu J, Ye Y, Wu H, Duerksen-Hughes P, Zhang H, Li P, Huang J, Yang J, Wu Y, Xia D. Association between markers of glucose metabolism and risk of colorectal cancer. Bmj Open. 6: e011430. PMID 27354075 DOI: 10.1136/bmjopen-2016-011430  1
2016 Chen Wongworawat Y, Filippova M, Williams VM, Filippov V, Duerksen-Hughes PJ. Chronic oxidative stress increases the integration frequency of foreign DNA and human papillomavirus 16 in human keratinocytes. American Journal of Cancer Research. 6: 764-80. PMID 27186429  1
2016 Yuan CH, Filippova M, Krstenansky JL, Duerksen-Hughes PJ. Flavonol and imidazole derivatives block HPV16 E6 activities and reactivate apoptotic pathways in HPV(+) cells. Cell Death & Disease. 7: 2060. PMID 26794656 DOI: 10.1038/cddis.2015.391  0.8
2016 Evans W, Filippova M, Filippov V, Bashkirova S, Zhang G, Reeves ME, Duerksen-Hughes P. Overexpression of HPV16 E6∗ alters β-integrin and mitochondrial dysfunction pathways in cervical cancer cells Cancer Genomics and Proteomics. 13: 259-274.  1
2015 Whang SN, Filippova M, Duerksen-Hughes P. Recent Progress in Therapeutic Treatments and Screening Strategies for the Prevention and Treatment of HPV-Associated Head and Neck Cancer. Viruses. 7: 5040-65. PMID 26393639 DOI: 10.3390/v7092860  1
2015 Carr KR, Ioffe YJ, Filippova M, Duerksen-Hughes P, Chan PJ. Combined ultrasound-curcumin treatment of human cervical cancer cells. European Journal of Obstetrics, Gynecology, and Reproductive Biology. 193: 96-101. PMID 26262768 DOI: 10.1016/j.ejogrb.2015.07.011  1
2014 Filippova M, Filippov V, Williams VM, Zhang K, Kokoza A, Bashkirova S, Duerksen-Hughes P. Cellular levels of oxidative stress affect the response of cervical cancer cells to chemotherapeutic agents. Biomed Research International. 2014: 574659. PMID 25478571 DOI: 10.1155/2014/574659  1
2014 Chen Y, Williams V, Filippova M, Filippov V, Duerksen-Hughes P. Viral carcinogenesis: factors inducing DNA damage and virus integration. Cancers. 6: 2155-86. PMID 25340830 DOI: 10.3390/cancers6042155  1
2014 Gao X, Kong L, Lu X, Zhang G, Chi L, Jiang Y, Wu Y, Yan C, Duerksen-Hughes P, Zhu X, Yang J. Paraspeckle protein 1 (PSPC1) is involved in the cisplatin induced DNA damage response--role in G1/S checkpoint. Plos One. 9: e97174. PMID 24819514 DOI: 10.1371/journal.pone.0097174  1
2014 Hsu HW, de Necochea-Campion R, Williams V, Duerksen-Hughes PJ, Simental AA, Ferris RL, Chen CS, Mirshahidi S. Linifanib (ABT-869), enhances cytotoxicity with poly (ADP-ribose) polymerase inhibitor, veliparib (ABT-888), in head and neck carcinoma cells. Oral Oncology. 50: 662-9. PMID 24735547 DOI: 10.1016/j.oraloncology.2014.03.006  1
2014 Williams VM, Filippova M, Filippov V, Payne KJ, Duerksen-Hughes P. Human papillomavirus type 16 E6* induces oxidative stress and DNA damage. Journal of Virology. 88: 6751-61. PMID 24696478 DOI: 10.1128/JVI.03355-13  1
2014 Yu Y, Fuscoe JC, Zhao C, Guo C, Jia M, Qing T, Bannon DI, Lancashire L, Bao W, Du T, Luo H, Su Z, Jones WD, Moland CL, Branham WS, ... ... Duerksen-Hughes P, et al. A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages. Nature Communications. 5: 3230. PMID 24510058 DOI: 10.1038/ncomms4230  1
2014 Filippova M, Evans W, Aragon R, Filippov V, Williams VM, Hong L, Reeves ME, Duerksen-Hughes P. The small splice variant of HPV16 E6, E6, reduces tumor formation in cervical carcinoma xenografts. Virology. 450: 153-64. PMID 24503078 DOI: 10.1016/j.virol.2013.12.011  1
2014 Ju L, Zhang G, Zhang X, Jia Z, Gao X, Jiang Y, Yan C, Duerksen-Hughes PJ, Chen FF, Li H, Zhu X, Yang J. Proteomic analysis of cellular response induced by multi-walled carbon nanotubes exposure in A549 cells. Plos One. 9: e84974. PMID 24454774 DOI: 10.1371/journal.pone.0084974  1
2014 Williams VM, Duerksen-Hughes P. Stress, The immune system and cancer Stress and Developmental Programming of Health and Disease: Beyond Phenomenology. 602-631.  1
2013 Ju L, Zhang G, Zhang C, Sun L, Jiang Y, Yan C, Duerksen-Hughes PJ, Zhang X, Zhu X, Chen FF, Yang J. Quantum dot-related genotoxicity perturbation can be attenuated by PEG encapsulation. Mutation Research. 753: 54-64. PMID 23416234 DOI: 10.1016/j.mrgentox.2013.01.006  1
2012 Yuan CH, Filippova M, Duerksen-Hughes P. Modulation of apoptotic pathways by human papillomaviruses (HPV): mechanisms and implications for therapy. Viruses. 4: 3831-50. PMID 23250450 DOI: 10.3390/v4123831  1
2012 Gan TE, Xiao SP, Jiang Y, Hu H, Wu YH, Duerksen-Hughes PJ, Sheng JZ, Yang J. Effects of benzo(a)pyrene on the contractile function of the thoracic aorta of Sprague-Dawley rats. Biomedical and Environmental Sciences : Bes. 25: 549-56. PMID 23122312 DOI: 10.3967/0895-3988.2012.05.008  1
2012 Jiang Y, Zhang XY, Sun L, Zhang GL, Duerksen-Hughes P, Zhu XQ, Yang J. Methyl methanesulfonate induces apoptosis in p53-deficient H1299 and Hep3B cells through a caspase 2- and mitochondria-associated pathway. Environmental Toxicology and Pharmacology. 34: 694-704. PMID 23117069 DOI: 10.1016/j.etap.2012.09.019  1
2012 Whitaker EL, Filippov VA, Duerksen-Hughes PJ. Interleukin 24: mechanisms and therapeutic potential of an anti-cancer gene. Cytokine & Growth Factor Reviews. 23: 323-31. PMID 22981288 DOI: 10.1016/j.cytogfr.2012.08.004  1
2012 Zhang G, Sun L, Lu X, Chen Z, Duerksen-Hughes PJ, Hu H, Zhu X, Yang J. Cisplatin treatment leads to changes in nuclear protein and microRNA expression. Mutation Research. 746: 66-77. PMID 22475935 DOI: 10.1016/j.mrgentox.2012.03.004  1
2012 Haynes TA, Filippov V, Filippova M, Yang J, Zhang K, Duerksen-Hughes PJ. DNA damage induces down-regulation of UDP-glucose ceramide glucosyltransferase, increases ceramide levels and triggers apoptosis in p53-deficient cancer cells. Biochimica Et Biophysica Acta. 1821: 943-53. PMID 22349266 DOI: 10.1016/j.bbalip.2012.02.002  1
2012 Yuan CH, Filippova M, Tungteakkhun SS, Duerksen-Hughes PJ, Krstenansky JL. Small molecule inhibitors of the HPV16-E6 interaction with caspase 8. Bioorganic & Medicinal Chemistry Letters. 22: 2125-9. PMID 22300659 DOI: 10.1016/j.bmcl.2011.12.145  1
2012 Filippov V, Song MA, Zhang K, Vinters HV, Tung S, Kirsch WM, Yang J, Duerksen-Hughes PJ. Increased ceramide in brains with Alzheimer's and other neurodegenerative diseases. Journal of Alzheimer's Disease : Jad. 29: 537-47. PMID 22258513 DOI: 10.3233/JAD-2011-111202  1
2012 Yan C, Chen Z, Li H, Zhang G, Li F, Duerksen-Hughes PJ, Zhu X, Yang J. Nuclear proteome analysis of benzo(a)pyrene-treated HeLa cells. Mutation Research. 731: 75-84. PMID 22138005 DOI: 10.1016/j.mrfmmm.2011.11.007  1
2011 Whitaker EL, Filippov V, Filippova M, Guerrero-Juarez CF, Duerksen-Hughes PJ. Splice variants of mda-7/IL-24 differentially affect survival and induce apoptosis in U2OS cells. Cytokine. 56: 272-81. PMID 21843952 DOI: 10.1016/j.cyto.2011.07.020  1
2011 Xiong L, Darwanto A, Sharma S, Herring J, Hu S, Filippova M, Filippov V, Wang Y, Chen CS, Duerksen-Hughes PJ, Sowers LC, Zhang K. Mass spectrometric studies on epigenetic interaction networks in cell differentiation. The Journal of Biological Chemistry. 286: 13657-68. PMID 21335548 DOI: 10.1074/jbc.M110.204800  1
2011 Williams VM, Filippova M, Soto U, Duerksen-Hughes PJ. HPV-DNA integration and carcinogenesis: putative roles for inflammation and oxidative stress. Future Virology. 6: 45-57. PMID 21318095 DOI: 10.2217/fvl.10.73  1
2011 Mujumdar PP, Duerksen-Hughes PJ, Firek AF, Hessinger DA. Long-term, progressive, aerobic training increases adiponectin in middle-aged, overweight, untrained males and females. Scandinavian Journal of Clinical and Laboratory Investigation. 71: 101-7. PMID 21271804 DOI: 10.3109/00365513.2011.554995  1
2011 Yan C, Lu J, Zhang G, Gan T, Zeng Q, Shao Z, Duerksen-Hughes PJ, Yang J. Benzo[a]pyrene induces complex H2AX phosphorylation patterns by multiple kinases including ATM, ATR, and DNA-PK. Toxicology in Vitro : An International Journal Published in Association With Bibra. 25: 91-9. PMID 20888899 DOI: 10.1016/j.tiv.2010.09.012  1
2011 Zhang K, Haynes TAS, Filippova M, Filippov V, Duerksen-Hughes PJ. Quantification of ceramide levels in mammalian cells by high performance liquid chromatography coupled to tandem mass spectrometry with multiple-reaction-monitoring mode (HPLC-MS/MS-MRM) Analytical Methods. 3: 1193-1197. DOI: 10.1039/c1ay05022b  1
2010 Wu W, Yan C, Gan T, Chen Z, Lu X, Duerksen-Hughes PJ, Zhu X, Yang J. Nuclear proteome analysis of cisplatin-treated HeLa cells. Mutation Research. 691: 1-8. PMID 20540955 DOI: 10.1016/j.mrfmmm.2010.06.002  1
2010 Yan C, Wu W, Li H, Zhang G, Duerksen-Hughes PJ, Zhu X, Yang J. Benzo[a]pyrene treatment leads to changes in nuclear protein expression and alternative splicing. Mutation Research. 686: 47-56. PMID 20097212 DOI: 10.1016/j.mrfmmm.2010.01.015  1
2010 Tungteakkhun SS, Filippova M, Fodor N, Duerksen-Hughes PJ. The full-length isoform of human papillomavirus 16 E6 and its splice variant E6* bind to different sites on the procaspase 8 death effector domain. Journal of Virology. 84: 1453-63. PMID 19906919 DOI: 10.1128/JVI.01331-09  1
2009 Filippova M, Filippov VA, Kagoda M, Garnett T, Fodor N, Duerksen-Hughes PJ. Complexes of human papillomavirus type 16 E6 proteins form pseudo-death-inducing signaling complex structures during tumor necrosis factor-mediated apoptosis. Journal of Virology. 83: 210-27. PMID 18842714 DOI: 10.1128/JVI.01365-08  1
2008 Tungteakkhun SS, Filippova M, Neidigh JW, Fodor N, Duerksen-Hughes PJ. The interaction between human papillomavirus type 16 and FADD is mediated by a novel E6 binding domain. Journal of Virology. 82: 9600-14. PMID 18632871 DOI: 10.1128/JVI.00538-08  1
2008 Filippov V, Schmidt EL, Filippova M, Duerksen-Hughes PJ. Splicing and splice factor SRp55 participate in the response to DNA damage by changing isoform ratios of target genes. Gene. 420: 34-41. PMID 18571879 DOI: 10.1016/j.gene.2008.05.008  1
2008 Haynes TA, Duerksen-Hughes PJ, Filippova M, Filippov V, Zhang K. C18 ceramide analysis in mammalian cells employing reversed-phase high-performance liquid chromatography tandem mass spectrometry. Analytical Biochemistry. 378: 80-6. PMID 18423390 DOI: 10.1016/j.ab.2008.03.045  1
2008 Tungteakkhun SS, Duerksen-Hughes PJ. Cellular binding partners of the human papillomavirus E6 protein. Archives of Virology. 153: 397-408. PMID 18172569 DOI: 10.1007/s00705-007-0022-5  1
2007 Filippov V, Filippova M, Duerksen-Hughes PJ. The early response to DNA damage can lead to activation of alternative splicing activity resulting in CD44 splice pattern changes. Cancer Research. 67: 7621-30. PMID 17699766 DOI: 10.1158/0008-5472.CAN-07-0145  1
2007 Garnett TO, Filippova M, Duerksen-Hughes PJ. Bid is cleaved upstream of caspase-8 activation during TRAIL-mediated apoptosis in human osteosarcoma cells. Apoptosis : An International Journal On Programmed Cell Death. 12: 1299-315. PMID 17431792 DOI: 10.1007/s10495-007-0058-8  1
2007 Filippova M, Johnson MM, Bautista M, Filippov V, Fodor N, Tungteakkhun SS, Williams K, Duerksen-Hughes PJ. The large and small isoforms of human papillomavirus type 16 E6 bind to and differentially affect procaspase 8 stability and activity. Journal of Virology. 81: 4116-29. PMID 17267478 DOI: 10.1128/JVI.01924-06  1
2006 Garnett TO, Duerksen-Hughes PJ. Modulation of apoptosis by human papillomavirus (HPV) oncoproteins. Archives of Virology. 151: 2321-35. PMID 16862386 DOI: 10.1007/s00705-006-0821-0  1
2006 Garnett TO, Filippova M, Duerksen-Hughes PJ. Accelerated degradation of FADD and procaspase 8 in cells expressing human papilloma virus 16 E6 impairs TRAIL-mediated apoptosis. Cell Death and Differentiation. 13: 1915-26. PMID 16528386 DOI: 10.1038/sj.cdd.4401886  1
2005 Filippova M, Brown-Bryan TA, Casiano CA, Duerksen-Hughes PJ. The human papillomavirus 16 E6 protein can either protect or further sensitize cells to TNF: effect of dose. Cell Death and Differentiation. 12: 1622-35. PMID 15933739 DOI: 10.1038/sj.cdd.4401678  1
2004 Yang J, Yu Y, Sun S, Duerksen-Hughes PJ. Ceramide and other sphingolipids in cellular responses. Cell Biochemistry and Biophysics. 40: 323-50. PMID 15211031 DOI: 10.1385/CBB:40:3:323  1
2004 Filippova M, Parkhurst L, Duerksen-Hughes PJ. The human papillomavirus 16 E6 protein binds to Fas-associated death domain and protects cells from Fas-triggered apoptosis. The Journal of Biological Chemistry. 279: 25729-44. PMID 15073179 DOI: 10.1074/jbc.M401172200  1
2004 Yang J, Xu ZP, Huang Y, Hamrick HE, Duerksen-Hughes PJ, Yu YN. ATM and ATR: sensing DNA damage. World Journal of Gastroenterology. 10: 155-60. PMID 14716813  1
2003 Yang J, Yu Y, Hamrick HE, Duerksen-Hughes PJ. ATM, ATR and DNA-PK: initiators of the cellular genotoxic stress responses. Carcinogenesis. 24: 1571-80. PMID 12919958 DOI: 10.1093/carcin/bgg137  1
2003 Filippova M, Duerksen-Hughes PJ. Inorganic and dimethylated arsenic species induce cellular p53. Chemical Research in Toxicology. 16: 423-31. PMID 12641444 DOI: 10.1021/tx025606a  1
2003 Yang J, Yu Y, Duerksen-Hughes PJ. Protein kinases and their involvement in the cellular responses to genotoxic stress. Mutation Research. 543: 31-58. PMID 12510016 DOI: 10.1016/S1383-5742(02)00069-8  1
2002 Filippova M, Song H, Connolly JL, Dermody TS, Duerksen-Hughes PJ. The human papillomavirus 16 E6 protein binds to tumor necrosis factor (TNF) R1 and protects cells from TNF-induced apoptosis. The Journal of Biological Chemistry. 277: 21730-9. PMID 11934887 DOI: 10.1074/jbc.M200113200  1
2001 Yang J, Duerksen-Hughes PJ. Activation of a p53-independent, Sphingolipid-mediated Cytolytic Pathway in p53-negative Mouse Fibroblast Cells Treated with N-Methyl-N-nitro-N-nitrosoguanidine Journal of Biological Chemistry. 276: 27129-27135. PMID 11369765 DOI: 10.1074/jbc.M100729200  1
1999 Duerksen-Hughes PJ, Yang J, Schwartz SB. HPV 16 E6 blocks TNF-mediated apoptosis in mouse fibroblast LM cells Virology. 264: 55-65. PMID 10544129 DOI: 10.1006/viro.1999.9977  1
1999 Duerksen-Hughes PJ, Yang J, Ozcan O. p53 induction as a genotoxic test for twenty-five chemicals undergoing in vivo carcinogenicity testing Environmental Health Perspectives. 107: 805-812. PMID 10504146  1
1999 Stenius U, Högberg J. Re: Yang, J. and Duerksen-Hughes, P. (1998) A new approach to identifying genotoxic carcinogens: p53 induction as an indicator of genotoxic damage. Carcinogenesis, 19, 1117-1125. Carcinogenesis. 20: 181-2. PMID 9934868 DOI: 10.1093/carcin/20.1.181  1
1998 Yang J, Duerksen-Hughes P. A new approach to identifying genotoxic carcinogens: P53 induction as an indicator of genotoxic damage Carcinogenesis. 19: 1117-1125. PMID 9667752 DOI: 10.1093/carcin/19.6.1117  1
1996 Shisler J, Duerksen-Hughes P, Hermiston TM, Wold WSM, Gooding LR. Induction of susceptibility to tumor necrosis factor by E1A Is dependent on binding to either p300 or p105-Rb and induction of DNA synthesis Journal of Virology. 70: 68-77. PMID 8523594  1
1996 Yang J, Duerksen-Hughes P. P53 induction as an indicator of genotoxic damage Faseb Journal. 10.  1
1993 Johnson BL, Damstra T, DeRosa C, Elmer C, Gilbert M. Workshop on toxicological data quality indicators. Toxicology and Industrial Health. 9: 577-604. PMID 8296312  1
1993 Derosa CT, Stevens YW, Wilson JD, Ademoyero AA, Buchanan SD, Cibulas W, Duerksen-Hughes PJ, Mumtaz MM, Neft RE, Pohl HR. The Agency for Toxic Substances and Disease Registry's role in development and application of biomarkers in public health practice. Toxicology and Industrial Health. 9: 979-94. PMID 8191504  1
1992 Duerksen-Hughes PJ, Day DB, Laster SM, Zachariades NA, Aquino L, Gooding LR. Both tumor necrosis factor and nitric oxide participate in lysis of simian virus 40-transformed cells by activated macrophages Journal of Immunology. 149: 2114-2122. PMID 1325525  1
1991 Gooding LR, Ranheim TS, Tollefson AE, Aquino L, Duerksen-Hughes P, Horton TM, Wold WS. The 10,400- and 14,500-dalton proteins encoded by region E3 of adenovirus function together to protect many but not all mouse cell lines against lysis by tumor necrosis factor. Journal of Virology. 65: 4114-23. PMID 1830111  1
1991 Gooding LR, Aquino L, Duerksen-Hughes PJ, Day D, Horton TM, Yei S, Wold WSM. The E1B 19,000-Molecular-Weight Protein of Group C Adenoviruses Prevents Tumor Necrosis Factor Cytolysis of Human Cells but Not of Mouse Cells Journal of Virology. 65: 3083-3094. PMID 1827845  1
1991 Rawle FC, Knowles BB, Ricciardi RP, Brahmacheri V, Duerksen-Hughes P, Wold WSM, Gooding LR. Specificity of the mouse cytotoxic T lymphocyte response to adenovirus 5: E1A is immunodominant in H-2b, but not in H-2d or H-2k mice Journal of Immunology. 146: 3977-3984. PMID 1827819  1
1991 Duerksen-Hughes PJ, Hermiston TW, Wold WSM, Gooding LR. The amino-terminal portion of CD1 of the adenovirus E1A proteins is required to induce susceptibility to tumor necrosis factor cytolysis in adenovirus-infected mouse cell Journal of Virology. 65: 1236-1244. PMID 1825340  1
1990 Gooding LR, Sofola IO, Tollefson AE, Duerksen-Hughes P, Wold WSM. The adenovirus E3-14.7K protein is a general inhibitor of tumor necrosis factor-mediated cytolysis Journal of Immunology. 145: 3080-3086. PMID 2145367  1
1989 Duerksen-Hughes P, Wold WSM, Gooding LR. Adenovirus E1A renders infected cells sensitive to cytolysis by tumor necrosis factor Journal of Immunology. 143: 4193-4200. PMID 2531778  1
1989 Wilkinson KD, Lee K, Deshpande S, Duerksen-Hughes P, Boss JM, Pohl J. The neuron-specific protein PGP 9.5 is a ubiquitin carboxyl-terminal hydrolase Science. 246: 670-673. PMID 2530630 DOI: 10.1126/science.2530630  1
1989 Duerksen-Hughes PJ, Williamson MM, Wilkinson KD. Affinity chromatography using protein immobilized via arginine residues: Purification of ubiquitin carboxyl-terminal hydrolases Biochemistry. 28: 8530-8536.  1
1987 Duerksen-Hughes PJ, Xu X, Wilkinson KD. Structure and function of ubiquitin: Evidence for differential interactions of arginine-74 with the activating enzyme and the proteases of ATP-dependent proteolysis Biochemistry. 26: 6980-6987. PMID 2827740  1
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