Scott J. Hultgren - Publications

Washington University, Saint Louis, St. Louis, MO 
Microbiology Biology

267 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2019 Yu L, O'Brien VP, Livny J, Dorsey D, Bandyopadhyay N, Colonna M, Caparon MG, Roberson ED, Hultgren SJ, Hannan TJ. Mucosal infection rewires TNFɑ signaling dynamics to skew susceptibility to recurrence. Elife. 8. PMID 31429405 DOI: 10.7554/eLife.46677  1
2019 Walker JN, Hanson BM, Pinkner CL, Simar SR, Pinkner JS, Parikh R, Clemens MW, Hultgren SJ, Myckatyn TM. Insights into the Microbiome of Breast Implants and Periprosthetic Tissue in Breast Implant-Associated Anaplastic Large Cell Lymphoma. Scientific Reports. 9: 10393. PMID 31316085 DOI: 10.1038/s41598-019-46535-8  1
2019 Walker JN, Poppler L, Pinkner CL, Hultgren SJ, Myckatyn T. Establishment and Characterization of Bacterial Infection of Breast Implants in a Murine Model. Aesthetic Surgery Journal. PMID 31259380 DOI: 10.1093/asj/sjz190  0.8
2019 Di Venanzio G, Flores-Mireles AL, Calix JJ, Haurat MF, Scott NE, Palmer LD, Potter RF, Hibbing ME, Friedman L, Wang B, Dantas G, Skaar EP, Hultgren SJ, Feldman MF. Urinary tract colonization is enhanced by a plasmid that regulates uropathogenic Acinetobacter baumannii chromosomal genes. Nature Communications. 10: 2763. PMID 31235751 DOI: 10.1038/s41467-019-10706-y  1
2019 Tamadonfar KO, Omattage NS, Spaulding CN, Hultgren SJ. Reaching the End of the Line: Urinary Tract Infections. Microbiology Spectrum. 7. PMID 31172909 DOI: 10.1128/microbiolspec.BAI-0014-2019  0.36
2019 Flentie K, Harrison GA, Tükenmez H, Livny J, Good JAD, Sarkar S, Zhu DX, Kinsella RL, Weiss LA, Solomon SD, Schene ME, Hansen MR, Cairns AG, Kulén M, Wixe T, ... ... Hultgren SJ, et al. Chemical disarming of isoniazid resistance in . Proceedings of the National Academy of Sciences of the United States of America. PMID 31061116 DOI: 10.1073/pnas.1818009116  0.64
2019 Walker JN, Pinkner CL, Lynch AJL, Ortbal S, Pinkner JS, Hultgren SJ, Myckatyn TM. Deposition of Host Matrix Proteins on Breast Implant Surfaces Facilitates Staphylococcus Epidermidis Biofilm Formation: In Vitro Analysis. Aesthetic Surgery Journal. PMID 30953053 DOI: 10.1093/asj/sjz099  1
2019 Walker JN, Pinkner CL, Pinkner JS, Hultgren SJ, Myckatyn TM. The Detection of Bacteria and Matrix Proteins on Clinically Benign and Pathologic Implants. Plastic and Reconstructive Surgery. Global Open. 7: e2037. PMID 30881821 DOI: 10.1097/GOX.0000000000002037  1
2018 O'Brien VP, Dorsey DA, Hannan TJ, Hultgren SJ. Host restriction of Escherichia coli recurrent urinary tract infection occurs in a bacterial strain-specific manner. Plos Pathogens. 14: e1007457. PMID 30543708 DOI: 10.1371/journal.ppat.1007457  0.76
2018 Maddirala A, Klein RD, Pinkner J, Kalas V, Hultgren SJ, Janetka JW. Biphenyl Gal and GalNAc FmlH Lectin Antagonists of Uropathogenic E. coli (UPEC): Optimization through iterative rational drug design. Journal of Medicinal Chemistry. PMID 30540910 DOI: 10.1021/acs.jmedchem.8b01561  0.4
2018 Omattage NS, Deng Z, Pinkner JS, Dodson KW, Almqvist F, Yuan P, Hultgren SJ. Structural basis for usher activation and intramolecular subunit transfer in P pilus biogenesis in Escherichia coli. Nature Microbiology. PMID 30275511 DOI: 10.1038/s41564-018-0255-y  1
2018 Colomer-Winter C, Flores-Mireles AL, Baker SP, Frank KL, Lynch AJL, Hultgren SJ, Kitten T, Lemos JA. Manganese acquisition is essential for virulence of Enterococcus faecalis. Plos Pathogens. 14: e1007102. PMID 30235334 DOI: 10.1371/journal.ppat.1007102  1
2018 Klein RD, Shu Q, Cusumano ZT, Nagamatsu K, Gualberto NC, Lynch AJL, Wu C, Wang W, Jain N, Pinkner JS, Amarasinghe GK, Hultgren SJ, Frieden C, Chapman MR. Structure-Function Analysis of the Curli Accessory Protein CsgE Defines Surfaces Essential for Coordinating Amyloid Fiber Formation. Mbio. 9. PMID 30018113 DOI: 10.1128/mBio.01349-18  1
2018 Schwan WR, Beck MT, Hung CS, Hultgren SJ. Differential Regulation of Genes following Binding to Mannose Receptors. Journal of Pathogens. 2018: 2897581. PMID 29951317 DOI: 10.1155/2018/2897581  1
2018 Shen J, Walsh BJC, Flores-Mireles AL, Peng H, Zhang Y, Zhang Y, Trinidad JC, Hultgren SJ, Giedroc DP. Hydrogen sulfide sensing through reactive sulfur species (RSS) and nitroxyl (HNO) in Enterococcus faecalis. Acs Chemical Biology. PMID 29712426 DOI: 10.1021/acschembio.8b00230  1
2018 Spaulding CN, Klein RD, Schreiber HL, Janetka JW, Hultgren SJ. Precision antimicrobial therapeutics: the path of least resistance? Npj Biofilms and Microbiomes. 4: 4. PMID 29507749 DOI: 10.1038/s41522-018-0048-3  0.4
2018 Kalas V, Hibbing ME, Maddirala AR, Chugani R, Pinkner JS, Mydock-McGrane LK, Conover MS, Janetka JW, Hultgren SJ. Structure-based discovery of glycomimetic FmlH ligands as inhibitors of bacterial adhesion during urinary tract infection. Proceedings of the National Academy of Sciences of the United States of America. PMID 29507247 DOI: 10.1073/pnas.1720140115  1
2017 Paharik AE, Schreiber HL, Spaulding CN, Dodson KW, Hultgren SJ. Narrowing the spectrum: the new frontier of precision antimicrobials. Genome Medicine. 9: 110. PMID 29241446 DOI: 10.1186/s13073-017-0504-3  0.6
2017 Xu W, Flores-Mireles AL, Cusumano ZT, Takagi E, Hultgren SJ, Caparon MG. Host and bacterial proteases influence biofilm formation and virulence in a murine model of enterococcal catheter-associated urinary tract infection. Npj Biofilms and Microbiomes. 3: 28. PMID 29134108 DOI: 10.1038/s41522-017-0036-z  1
2017 Walker JN, Flores-Mireles AL, Pinkner CL, Schreiber HL, Joens MS, Park AM, Potretzke AM, Bauman TM, Pinkner JS, Fitzpatrick JAJ, Desai A, Caparon MG, Hultgren SJ. Catheterization alters bladder ecology to potentiate Staphylococcus aureus infection of the urinary tract. Proceedings of the National Academy of Sciences of the United States of America. PMID 28973850 DOI: 10.1073/pnas.1707572114  1
2017 Spaulding CN, Klein RD, Ruer S, Kau AL, Schreiber HL, Cusumano ZT, Dodson KW, Pinkner JS, Fremont DH, Janetka JW, Remaut H, Gordon JI, Hultgren SJ. Selective depletion of uropathogenic E. coli from the gut by a FimH antagonist. Nature. PMID 28614296 DOI: 10.1038/nature22972  1
2017 Schreiber HL, Conover MS, Chou WC, Hibbing ME, Manson AL, Dodson KW, Hannan TJ, Roberts PL, Stapleton AE, Hooton TM, Livny J, Earl AM, Hultgren SJ. Bacterial virulence phenotypes of Escherichia coli and host susceptibility determine risk for urinary tract infections. Science Translational Medicine. 9. PMID 28330863 DOI: 10.1126/scitranslmed.aaf1283  0.76
2017 Kalas V, Pinkner JS, Hannan TJ, Hibbing ME, Dodson KW, Holehouse AS, Zhang H, Tolia NH, Gross ML, Pappu RV, Janetka J, Hultgren SJ. Evolutionary fine-tuning of conformational ensembles in FimH during host-pathogen interactions. Science Advances. 3: e1601944. PMID 28246638 DOI: 10.1126/sciadv.1601944  1
2017 Schreiber HL, Spaulding CN, Dodson KW, Livny J, Hultgren SJ. One size doesn't fit all: unraveling the diversity of factors and interactions that drive E. coli urovirulence. Annals of Translational Medicine. 5: 28. PMID 28217693 DOI: 10.21037/atm.2016.12.73  0.6
2016 O'Brien VP, Hannan TJ, Yu L, Livny J, Roberson ED, Schwartz DJ, Souza S, Mendelsohn CL, Colonna M, Lewis AL, Hultgren SJ. A mucosal imprint left by prior Escherichia coli bladder infection sensitizes to recurrent disease. Nature Microbiology. 2: 16196. PMID 27798558 DOI: 10.1038/nmicrobiol.2016.196  0.76
2016 Flores-Mireles AL, Walker JN, Potretzke A, Schreiber HL, Pinkner JS, Bauman TM, Park AM, Desai A, Hultgren SJ, Caparon MG. Antibody-Based Therapy for Enterococcal Catheter-Associated Urinary Tract Infections. Mbio. 7. PMID 27795399 DOI: 10.1128/mBio.01653-16  1
2016 Hufnagel DA, Evans ML, Greene SE, Pinkner JS, Hultgren SJ, Chapman MR. CRP-cAMP regulates csgD and biofilm formation by uropathogenic Escherichia coli. Journal of Bacteriology. PMID 27698083 DOI: 10.1128/JB.00652-16  1
2016 Mydock-McGrane L, Cusumano Z, Han Z, Binkley J, Kostakioti M, Hannan T, Pinkner JS, Klein RD, Kalas V, Crowley J, Rath NP, Hultgren SJ, Janetka JW. Anti-virulence C-mannoisdes as antibiotic-sparing, oral therapeutics for urinary tract infections. Journal of Medicinal Chemistry. PMID 27689912 DOI: 10.1021/acs.jmedchem.6b00948  1
2016 Conover MS, Ruer S, Taganna J, Kalas V, De Greve H, Pinkner JS, Dodson KW, Remaut H, Hultgren SJ. Inflammation-Induced Adhesin-Receptor Interaction Provides a Fitness Advantage to Uropathogenic E. coli during Chronic Infection. Cell Host & Microbe. PMID 27667696 DOI: 10.1016/j.chom.2016.08.013  1
2016 Shu Q, Krezel AM, Cusumano ZT, Pinkner JS, Klein R, Hultgren SJ, Frieden C. Solution NMR structure of CsgE: Structural insights into a chaperone and regulator protein important for functional amyloid formation. Proceedings of the National Academy of Sciences of the United States of America. PMID 27298344 DOI: 10.1073/pnas.1607222113  0.32
2016 Floyd KA, Mitchell CA, Eberly AR, Colling SJ, Zhang EW, DePas W, Chapman MR, Conover M, Rogers BR, Hultgren SJ, Hadjifrangiskou M. "The UbiI (VisC) aerobic ubiquinone synthase is required for expression of type 1 pili, biofilm formation, and pathogenesis in uropathogenic Escherichia coli". Journal of Bacteriology. PMID 27161114 DOI: 10.1128/JB.00030-16  0.32
2016 Conover MS, Hadjifrangiskou M, Palermo JJ, Hibbing ME, Dodson KW, Hultgren SJ. Metabolic Requirements of Escherichia coli in Intracellular Bacterial Communities during Urinary Tract Infection Pathogenesis. Mbio. 7. PMID 27073089 DOI: 10.1128/mBio.00104-16  1
2016 O'Brien VP, Hannan TJ, Nielsen HV, Hultgren SJ. Drug and Vaccine Development for the Treatment and Prevention of Urinary Tract Infections. Microbiology Spectrum. 4. PMID 26999391 DOI: 10.1128/microbiolspec.UTI-0013-2012  1
2016 Spaulding CN, Hultgren SJ. Adhesive Pili in UTI Pathogenesis and Drug Development. Pathogens (Basel, Switzerland). 5. PMID 26999218 DOI: 10.3390/pathogens5010030  0.36
2016 Flores-Mireles AL, Walker JN, Bauman TM, Potretzke AM, Schreiber HL, Park AM, Pinkner JS, Caparon MG, Hultgren SJ, Desai A. Fibrinogen release and deposition on urinary catheters placed during urologic procedures. The Journal of Urology. PMID 26827873 DOI: 10.1016/j.juro.2016.01.100  0.32
2016 Jarvis C, Han Z, Kalas V, Klein R, Pinkner JS, Ford B, Binkley J, Cusumano CK, Cusumano Z, Mydock-McGrane L, Hultgren SJ, Janetka JW. Antivirulence Isoquinolone Mannosides: Optimization of the Biaryl Aglycone for FimH Lectin Binding Affinity and Efficacy in the Treatment of Chronic UTI. Chemmedchem. PMID 26812660 DOI: 10.1002/cmdc.201600006  1
2016 Hospenthal MK, Redzej A, Dodson K, Ukleja M, Frenz B, Rodrigues C, Hultgren SJ, DiMaio F, Egelman EH, Waksman G. Structure of a Chaperone-Usher Pilus Reveals the Molecular Basis of Rod Uncoiling. Cell. 164: 269-78. PMID 26724865 DOI: 10.1016/j.cell.2015.11.049  0.32
2015 Van Gerven N, Klein RD, Hultgren SJ, Remaut H. Bacterial Amyloid Formation: Structural Insights into Curli Biogensis. Trends in Microbiology. 23: 693-706. PMID 26439293 DOI: 10.1016/j.tim.2015.07.010  0.32
2015 Spaulding CN, Dodson KW, Chapman MR, Hultgren SJ. Fueling the Fire with Fibers: Bacterial Amyloids Promote Inflammatory Disorders. Cell Host & Microbe. 18: 1-2. PMID 26159711 DOI: 10.1016/j.chom.2015.06.013  1
2015 Conover MS, Flores-Mireles AL, Hibbing ME, Dodson K, Hultgren SJ. Establishment and Characterization of UTI and CAUTI in a Mouse Model. Journal of Visualized Experiments : Jove. e52892. PMID 26132341 DOI: 10.3791/52892  0.32
2015 Greene SE, Hibbing ME, Janetka J, Chen SL, Hultgren SJ. Human Urine Decreases Function and Expression of Type 1 Pili in Uropathogenic Escherichia coli. Mbio. 6. PMID 26126855 DOI: 10.1128/mBio.00820-15  1
2015 Hibbing ME, Conover MS, Hultgren SJ. The unexplored relationship between urinary tract infections and the autonomic nervous system. Autonomic Neuroscience : Basic & Clinical. PMID 26108548 DOI: 10.1016/j.autneu.2015.06.002  0.68
2015 Werneburg GT, Henderson NS, Portnoy EB, Sarowar S, Hultgren SJ, Li H, Thanassi DG. The pilus usher controls protein interactions via domain masking and is functional as an oligomer. Nature Structural & Molecular Biology. 22: 540-6. PMID 26052892 DOI: 10.1038/nsmb.3044  1
2015 Lin AE, Beasley FC, Olson J, Keller N, Shalwitz RA, Hannan TJ, Hultgren SJ, Nizet V. Role of Hypoxia Inducible Factor-1α (HIF-1α) in Innate Defense against Uropathogenic Escherichia coli Infection. Plos Pathogens. 11: e1004818. PMID 25927232 DOI: 10.1371/journal.ppat.1004818  1
2015 Flores-Mireles AL, Walker JN, Caparon M, Hultgren SJ. Urinary tract infections: epidemiology, mechanisms of infection and treatment options. Nature Reviews. Microbiology. 13: 269-84. PMID 25853778 DOI: 10.1038/nrmicro3432  1
2015 Goneau LW, Hannan TJ, MacPhee RA, Schwartz DJ, Macklaim JM, Gloor GB, Razvi H, Reid G, Hultgren SJ, Burton JP. Subinhibitory antibiotic therapy alters recurrent urinary tract infection pathogenesis through modulation of bacterial virulence and host immunity. Mbio. 6. PMID 25827417 DOI: 10.1128/mBio.00356-15  0.76
2015 Nagamatsu K, Hannan TJ, Guest RL, Kostakioti M, Hadjifrangiskou M, Binkley J, Dodson K, Raivio TL, Hultgren SJ. Dysregulation of Escherichia coli α-hemolysin expression alters the course of acute and persistent urinary tract infection. Proceedings of the National Academy of Sciences of the United States of America. 112: E871-80. PMID 25675528 DOI: 10.1073/pnas.1500374112  1
2015 Klein RD, Hultgren SJ. Chaos controlled: discovery of a powerful amyloid inhibitor. Molecular Cell. 57: 391-3. PMID 25658202 DOI: 10.1016/j.molcel.2015.01.031  1
2015 Schwartz DJ, Conover MS, Hannan TJ, Hultgren SJ. Uropathogenic Escherichia coli superinfection enhances the severity of mouse bladder infection. Plos Pathogens. 11: e1004599. PMID 25569799 DOI: 10.1371/journal.ppat.1004599  0.76
2015 Engström P, Krishnan KS, Ngyuen BD, Chorell E, Normark J, Silver J, Bastidas RJ, Welch MD, Hultgren SJ, Wolf-Watz H, Valdivia RH, Almqvist F, Bergström S. A 2-pyridone-amide inhibitor targets the glucose metabolism pathway of Chlamydia trachomatis. Mbio. 6: e02304-14. PMID 25550323 DOI: 10.1128/mBio.02304-14  1
2015 O'Brien VP, Hannan TJ, Schaeffer AJ, Hultgren SJ. Are you experienced? Understanding bladder innate immunity in the context of recurrent urinary tract infection. Current Opinion in Infectious Diseases. 28: 97-105. PMID 25517222 DOI: 10.1097/QCO.0000000000000130  1
2014 Hannan TJ, Roberts PL, Riehl TE, van der Post S, Binkley JM, Schwartz DJ, Miyoshi H, Mack M, Schwendener RA, Hooton TM, Stappenbeck TS, Hansson GC, Stenson WF, Colonna M, Stapleton AE, ... Hultgren SJ, et al. Inhibition of Cyclooxygenase-2 Prevents Chronic and Recurrent Cystitis. Ebiomedicine. 1: 46-57. PMID 26125048 DOI: 10.1016/j.ebiom.2014.10.011  0.76
2014 Greene SE, Pinkner JS, Chorell E, Dodson KW, Shaffer CL, Conover MS, Livny J, Hadjifrangiskou M, Almqvist F, Hultgren SJ. Pilicide ec240 disrupts virulence circuits in uropathogenic Escherichia coli. Mbio. 5: e02038. PMID 25352623 DOI: 10.1128/mBio.02038-14  1
2014 Ekiert DC, Cox JS. Structure of a PE-PPE-EspG complex from Mycobacterium tuberculosis reveals molecular specificity of ESX protein secretion. Proceedings of the National Academy of Sciences of the United States of America. 111: 14758-63. PMID 25275011 DOI: 10.1073/pnas.1409345111  1
2014 Flores-Mireles AL, Pinkner JS, Caparon MG, Hultgren SJ. EbpA vaccine antibodies block binding of Enterococcus faecalis to fibrinogen to prevent catheter-associated bladder infection in mice. Science Translational Medicine. 6: 254ra127. PMID 25232179 DOI: 10.1126/scitranslmed.3009384  1
2014 Goyal P, Krasteva PV, Van Gerven N, Gubellini F, Van den Broeck I, Troupiotis-Tsaïlaki A, Jonckheere W, Péhau-Arnaudet G, Pinkner JS, Chapman MR, Hultgren SJ, Howorka S, Fronzes R, Remaut H. Structural and mechanistic insights into the bacterial amyloid secretion channel CsgG. Nature. 516: 250-3. PMID 25219853 DOI: 10.1038/nature13768  1
2014 Dang HT, Chorell E, Uvell H, Pinkner JS, Hultgren SJ, Almqvist F. Syntheses and biological evaluation of 2-amino-3-acyl-tetrahydrobenzothiophene derivatives; antibacterial agents with antivirulence activity. Organic & Biomolecular Chemistry. 12: 1942-56. PMID 24531242 DOI: 10.1039/c3ob42478b  1
2013 Volkan E, Kalas V, Pinkner JS, Dodson KW, Henderson NS, Pham T, Waksman G, Delcour AH, Thanassi DG, Hultgren SJ. Molecular basis of usher pore gating in Escherichia coli pilus biogenesis. Proceedings of the National Academy of Sciences of the United States of America. 110: 20741-6. PMID 24297893 DOI: 10.1073/pnas.1320528110  1
2013 Kandaswamy K, Liew TH, Wang CY, Huston-Warren E, Meyer-Hoffert U, Hultenby K, Schröder JM, Caparon MG, Normark S, Henriques-Normark B, Hultgren SJ, Kline KA. Focal targeting by human β-defensin 2 disrupts localized virulence factor assembly sites in Enterococcus faecalis. Proceedings of the National Academy of Sciences of the United States of America. 110: 20230-5. PMID 24191013 DOI: 10.1073/pnas.1319066110  1
2013 Guckes KR, Kostakioti M, Breland EJ, Gu AP, Shaffer CL, Martinez CR, Hultgren SJ, Hadjifrangiskou M. Strong cross-system interactions drive the activation of the QseB response regulator in the absence of its cognate sensor. Proceedings of the National Academy of Sciences of the United States of America. 110: 16592-7. PMID 24062463 DOI: 10.1073/pnas.1315320110  1
2013 Hung C, Zhou Y, Pinkner JS, Dodson KW, Crowley JR, Heuser J, Chapman MR, Hadjifrangiskou M, Henderson JP, Hultgren SJ. Escherichia coli biofilms have an organized and complex extracellular matrix structure. Mbio. 4: e00645-13. PMID 24023384 DOI: 10.1128/mBio.00645-13  1
2013 Schwartz DJ, Kalas V, Pinkner JS, Chen SL, Spaulding CN, Dodson KW, Hultgren SJ. Positively selected FimH residues enhance virulence during urinary tract infection by altering FimH conformation. Proceedings of the National Academy of Sciences of the United States of America. 110: 15530-7. PMID 24003161 DOI: 10.1073/pnas.1315203110  1
2013 Nielsen HV, Flores-Mireles AL, Kau AL, Kline KA, Pinkner JS, Neiers F, Normark S, Henriques-Normark B, Caparon MG, Hultgren SJ. Pilin and sortase residues critical for endocarditis- and biofilm-associated pilus biogenesis in Enterococcus faecalis. Journal of Bacteriology. 195: 4484-95. PMID 23913319 DOI: 10.1128/JB.00451-13  1
2013 Silverman JA, Schreiber HL, Hooton TM, Hultgren SJ. From physiology to pharmacy: developments in the pathogenesis and treatment of recurrent urinary tract infections. Current Urology Reports. 14: 448-56. PMID 23832844 DOI: 10.1007/s11934-013-0354-5  1
2013 Hannan TJ, Hooton TM, Hultgren SJ. Estrogen and recurrent UTI: what are the facts? Science Translational Medicine. 5: 190fs23. PMID 23785033 DOI: 10.1126/scitranslmed.3006423  1
2013 Totsika M, Kostakioti M, Hannan TJ, Upton M, Beatson SA, Janetka JW, Hultgren SJ, Schembri MA. A FimH inhibitor prevents acute bladder infection and treats chronic cystitis caused by multidrug-resistant uropathogenic Escherichia coli ST131. The Journal of Infectious Diseases. 208: 921-8. PMID 23737602 DOI: 10.1093/infdis/jit245  1
2013 Chen SL, Wu M, Henderson JP, Hooton TM, Hibbing ME, Hultgren SJ, Gordon JI. Genomic diversity and fitness of E. coli strains recovered from the intestinal and urinary tracts of women with recurrent urinary tract infection. Science Translational Medicine. 5: 184ra60. PMID 23658245 DOI: 10.1126/scitranslmed.3005497  1
2013 Geibel S, Procko E, Hultgren SJ, Baker D, Waksman G. Structural and energetic basis of folded-protein transport by the FimD usher. Nature. 496: 243-6. PMID 23579681 DOI: 10.1038/nature12007  1
2013 Kostakioti M, Hadjifrangiskou M, Hultgren SJ. Bacterial biofilms: development, dispersal, and therapeutic strategies in the dawn of the postantibiotic era. Cold Spring Harbor Perspectives in Medicine. 3: a010306. PMID 23545571 DOI: 10.1101/cshperspect.a010306  1
2013 Monack DM, Hultgren SJ. The complex interactions of bacterial pathogens and host defenses. Current Opinion in Microbiology. 16: 1-3. PMID 23518336 DOI: 10.1016/j.mib.2013.03.001  1
2013 Frank KL, Guiton PS, Barnes AM, Manias DA, Chuang-Smith ON, Kohler PL, Spaulding AR, Hultgren SJ, Schlievert PM, Dunny GM. AhrC and Eep are biofilm infection-associated virulence factors in Enterococcus faecalis. Infection and Immunity. 81: 1696-708. PMID 23460519 DOI: 10.1128/IAI.01210-12  1
2013 Watson ME, Nielsen HV, Hultgren SJ, Caparon MG. Murine vaginal colonization model for investigating asymptomatic mucosal carriage of Streptococcus pyogenes. Infection and Immunity. 81: 1606-17. PMID 23460515 DOI: 10.1128/IAI.00021-13  1
2013 Allen WJ, Phan G, Hultgren SJ, Waksman G. Dissection of pilus tip assembly by the FimD usher monomer. Journal of Molecular Biology. 425: 958-67. PMID 23295826 DOI: 10.1016/j.jmb.2012.12.024  1
2013 Guiton PS, Hannan TJ, Ford B, Caparon MG, Hultgren SJ. Enterococcus faecalis overcomes foreign body-mediated inflammation to establish urinary tract infections. Infection and Immunity. 81: 329-39. PMID 23132492 DOI: 10.1128/IAI.00856-12  1
2013 Kalas V, Volkan E, Hultgren SJ. Adhesive pili of the chaperone-usher family Escherichia Coli: Pathotypes and Principles of Pathogenesis: Second Edition. 363-386. DOI: 10.1016/B978-0-12-397048-0.00012-7  0.32
2012 Kostakioti M, Hultgren SJ, Hadjifrangiskou M. Molecular blueprint of uropathogenic Escherichia coli virulence provides clues toward the development of anti-virulence therapeutics. Virulence. 3: 592-4. PMID 23154288 DOI: 10.4161/viru.22364  0.48
2012 Floyd RV, Upton M, Hultgren SJ, Wray S, Burdyga TV, Winstanley C. Escherichia coli-mediated impairment of ureteric contractility is uropathogenic E. coli specific. The Journal of Infectious Diseases. 206: 1589-96. PMID 23002447 DOI: 10.1093/infdis/jis554  1
2012 Kline KA, Schwartz DJ, Gilbert NM, Hultgren SJ, Lewis AL. Immune modulation by group B Streptococcus influences host susceptibility to urinary tract infection by uropathogenic Escherichia coli. Infection and Immunity. 80: 4186-94. PMID 22988014 DOI: 10.1128/IAI.00684-12  1
2012 Hadjifrangiskou M, Gu AP, Pinkner JS, Kostakioti M, Zhang EW, Greene SE, Hultgren SJ. Transposon mutagenesis identifies uropathogenic Escherichia coli biofilm factors. Journal of Bacteriology. 194: 6195-205. PMID 22984258 DOI: 10.1128/JB.01012-12  1
2012 Nielsen HV, Guiton PS, Kline KA, Port GC, Pinkner JS, Neiers F, Normark S, Henriques-Normark B, Caparon MG, Hultgren SJ. The metal ion-dependent adhesion site motif of the Enterococcus faecalis EbpA pilin mediates pilus function in catheter-associated urinary tract infection. Mbio. 3: e00177-12. PMID 22829678 DOI: 10.1128/mBio.00177-12  1
2012 Guiton PS, Cusumano CK, Kline KA, Dodson KW, Han Z, Janetka JW, Henderson JP, Caparon MG, Hultgren SJ. Combinatorial small-molecule therapy prevents uropathogenic Escherichia coli catheter-associated urinary tract infections in mice. Antimicrobial Agents and Chemotherapy. 56: 4738-45. PMID 22733070 DOI: 10.1128/AAC.00447-12  1
2012 Kostakioti M, Hadjifrangiskou M, Cusumano CK, Hannan TJ, Janetka JW, Hultgren SJ. Distinguishing the contribution of type 1 pili from that of other QseB-misregulated factors when QseC is absent during urinary tract infection Infection and Immunity. 80: 2826-2834. PMID 22665375 DOI: 10.1128/IAI.00283-12  1
2012 Volkan E, Ford BA, Pinkner JS, Dodson KW, Henderson NS, Thanassi DG, Waksman G, Hultgren SJ. Domain activities of PapC usher reveal the mechanism of action of an Escherichia coli molecular machine. Proceedings of the National Academy of Sciences of the United States of America. 109: 9563-8. PMID 22645361 DOI: 10.1073/pnas.1207085109  1
2012 Hadjifrangiskou M, Hultgren SJ. What does it take to stick around? Molecular insights into biofilm formation by uropathogenic Escherichia coli. Virulence. 3: 231-3. PMID 22546905 DOI: 10.4161/viru.19763  1
2012 Shu Q, Crick SL, Pinkner JS, Ford B, Hultgren SJ, Frieden C. The E. coli CsgB nucleator of curli assembles to β-sheet oligomers that alter the CsgA fibrillization mechanism. Proceedings of the National Academy of Sciences of the United States of America. 109: 6502-7. PMID 22493266 DOI: 10.1073/pnas.1204161109  1
2012 Chorell E, Pinkner JS, Bengtsson C, Banchelin TS, Edvinsson S, Linusson A, Hultgren SJ, Almqvist F. Mapping pilicide anti-virulence effect in Escherichia coli, a comprehensive structure-activity study. Bioorganic & Medicinal Chemistry. 20: 3128-42. PMID 22464688 DOI: 10.1016/j.bmc.2012.01.048  1
2012 Han Z, Pinkner JS, Ford B, Chorell E, Crowley JM, Cusumano CK, Campbell S, Henderson JP, Hultgren SJ, Janetka JW. Lead optimization studies on FimH antagonists: discovery of potent and orally bioavailable ortho-substituted biphenyl mannosides. Journal of Medicinal Chemistry. 55: 3945-59. PMID 22449031 DOI: 10.1021/jm300165m  1
2012 Chorell E, Pinkner JS, Bengtsson C, Edvinsson S, Cusumano CK, Rosenbaum E, Johansson LB, Hultgren SJ, Almqvist F. Design and synthesis of fluorescent pilicides and curlicides: bioactive tools to study bacterial virulence mechanisms. Chemistry (Weinheim An Der Bergstrasse, Germany). 18: 4522-32. PMID 22431310 DOI: 10.1002/chem.201103936  1
2012 Hannan TJ, Totsika M, Mansfield KJ, Moore KH, Schembri MA, Hultgren SJ. Host-pathogen checkpoints and population bottlenecks in persistent and intracellular uropathogenic Escherichia coli bladder infection. Fems Microbiology Reviews. 36: 616-48. PMID 22404313 DOI: 10.1111/j.1574-6976.2012.00339.x  1
2012 Lin LY, Tiemann KM, Li Y, Pinkner JS, Walker JN, Hultgren SJ, Hunstad DA, Wooley KL. Synthetic polymer nanoparticles conjugated with FimH(A) from E. coli pili to emulate the bacterial mode of epithelial internalization. Journal of the American Chemical Society. 134: 3938-41. PMID 22360307 DOI: 10.1021/ja2091917  1
2012 Horvath I, Weise CF, Andersson EK, Chorell E, Sellstedt M, Bengtsson C, Olofsson A, Hultgren SJ, Chapman M, Wolf-Watz M, Almqvist F, Wittung-Stafshede P. Mechanisms of protein oligomerization: inhibitor of functional amyloids templates α-synuclein fibrillation. Journal of the American Chemical Society. 134: 3439-44. PMID 22260746 DOI: 10.1021/ja209829m  1
2012 Klinth JE, Pinkner JS, Hultgren SJ, Almqvist F, Uhlin BE, Axner O. Impairment of the biomechanical compliance of P pili: a novel means of inhibiting uropathogenic bacterial infections? European Biophysics Journal : Ebj. 41: 285-95. PMID 22237603 DOI: 10.1007/s00249-011-0784-2  1
2012 Tenke P, Köves B, Nagy K, Hultgren SJ, Mendling W, Wullt B, Grabe M, Wagenlehner FM, Cek M, Pickard R, Botto H, Naber KG, Bjerklund Johansen TE. Update on biofilm infections in the urinary tract. World Journal of Urology. 30: 51-7. PMID 21590469 DOI: 10.1007/s00345-011-0689-9  1
2011 Cusumano CK, Pinkner JS, Han Z, Greene SE, Ford BA, Crowley JR, Henderson JP, Janetka JW, Hultgren SJ. Treatment and prevention of urinary tract infection with orally active FimH inhibitors. Science Translational Medicine. 3: 109ra115. PMID 22089451 DOI: 10.1126/scitranslmed.3003021  1
2011 Schwartz DJ, Chen SL, Hultgren SJ, Seed PC. Population dynamics and niche distribution of uropathogenic Escherichia coli during acute and chronic urinary tract infection. Infection and Immunity. 79: 4250-9. PMID 21807904 DOI: 10.1128/IAI.05339-11  0.68
2011 Kline KA, Schwartz DJ, Lewis WG, Hultgren SJ, Lewis AL. Immune activation and suppression by group B streptococcus in a murine model of urinary tract infection. Infection and Immunity. 79: 3588-95. PMID 21690238 DOI: 10.1128/IAI.00122-11  1
2011 Nenninger AA, Robinson LS, Hammer ND, Epstein EA, Badtke MP, Hultgren SJ, Chapman MR. CsgE is a curli secretion specificity factor that prevents amyloid fibre aggregation. Molecular Microbiology. 81: 486-99. PMID 21645131 DOI: 10.1111/j.1365-2958.2011.07706.x  1
2011 Phan G, Remaut H, Wang T, Allen WJ, Pirker KF, Lebedev A, Henderson NS, Geibel S, Volkan E, Yan J, Kunze MB, Pinkner JS, Ford B, Kay CW, Li H, ... Hultgren SJ, et al. Crystal structure of the FimD usher bound to its cognate FimC-FimH substrate. Nature. 474: 49-53. PMID 21637253 DOI: 10.1038/nature10109  1
2011 Hadjifrangiskou M, Kostakioti M, Hultgren SJ. Antitoxins: therapy for stressed bacteria. Nature Chemical Biology. 7: 345-7. PMID 21587255 DOI: 10.1038/nchembio.584  1
2011 Hadjifrangiskou M, Kostakioti M, Chen SL, Henderson JP, Greene SE, Hultgren SJ. A central metabolic circuit controlled by QseC in pathogenic Escherichia coli. Molecular Microbiology. 80: 1516-29. PMID 21542868 DOI: 10.1111/j.1365-2958.2011.07660.x  1
2011 Chorell E, Bengtsson C, Sainte-Luce Banchelin T, Das P, Uvell H, Sinha AK, Pinkner JS, Hultgren SJ, Almqvist F. Synthesis and application of a bromomethyl substituted scaffold to be used for efficient optimization of anti-virulence activity. European Journal of Medicinal Chemistry. 46: 1103-16. PMID 21316127 DOI: 10.1016/j.ejmech.2011.01.025  1
2011 Smith CL, Ghosh J, Elam JS, Pinkner JS, Hultgren SJ, Caparon MG, Ellenberger T. Structural basis of Streptococcus pyogenes immunity to its NAD+ glycohydrolase toxin. Structure (London, England : 1993). 19: 192-202. PMID 21300288 DOI: 10.1016/j.str.2010.12.013  1
2011 Horvath DJ, Li B, Casper T, Partida-Sanchez S, Hunstad DA, Hultgren SJ, Justice SS. Morphological plasticity promotes resistance to phagocyte killing of uropathogenic Escherichia coli. Microbes and Infection / Institut Pasteur. 13: 426-37. PMID 21182979 DOI: 10.1016/j.micinf.2010.12.004  1
2010 Hannan TJ, Mysorekar IU, Hung CS, Isaacson-Schmid ML, Hultgren SJ. Early severe inflammatory responses to uropathogenic E. coli predispose to chronic and recurrent urinary tract infection. Plos Pathogens. 6: e1001042. PMID 20811584 DOI: 10.1371/journal.ppat.1001042  1
2010 Guiton PS, Hung CS, Hancock LE, Caparon MG, Hultgren SJ. Enterococcal biofilm formation and virulence in an optimized murine model of foreign body-associated urinary tract infections. Infection and Immunity. 78: 4166-75. PMID 20696830 DOI: 10.1128/IAI.00711-10  1
2010 Chorell E, Pinkner JS, Phan G, Edvinsson S, Buelens F, Remaut H, Waksman G, Hultgren SJ, Almqvist F. Design and synthesis of C-2 substituted thiazolo and dihydrothiazolo ring-fused 2-pyridones: pilicides with increased antivirulence activity. Journal of Medicinal Chemistry. 53: 5690-5. PMID 20586493 DOI: 10.1021/jm100470t  1
2010 Han Z, Pinkner JS, Ford B, Obermann R, Nolan W, Wildman SA, Hobbs D, Ellenberger T, Cusumano CK, Hultgren SJ, Janetka JW. Structure-based drug design and optimization of mannoside bacterial FimH antagonists. Journal of Medicinal Chemistry. 53: 4779-92. PMID 20507142 DOI: 10.1021/jm100438s  1
2010 Kline KA, Dodson KW, Caparon MG, Hultgren SJ. A tale of two pili: assembly and function of pili in bacteria. Trends in Microbiology. 18: 224-32. PMID 20378353 DOI: 10.1016/j.tim.2010.03.002  1
2010 Li Q, Ng TW, Dodson KW, So SS, Bayle KM, Pinkner JS, Scarlata S, Hultgren SJ, Thanassi DG. The differential affinity of the usher for chaperone-subunit complexes is required for assembly of complete pili. Molecular Microbiology. 76: 159-72. PMID 20199591 DOI: 10.1111/j.1365-2958.2010.07089.x  1
2010 Kline KA, Ingersoll MA, Nielsen HV, Sakinc T, Henriques-Normark B, Gatermann S, Caparon MG, Hultgren SJ. Characterization of a novel murine model of Staphylococcus saprophyticus urinary tract infection reveals roles for Ssp and SdrI in virulence. Infection and Immunity. 78: 1943-51. PMID 20176795 DOI: 10.1128/IAI.01235-09  1
2010 Cusumano CK, Hung CS, Chen SL, Hultgren SJ. Virulence plasmid harbored by uropathogenic Escherichia coli functions in acute stages of pathogenesis. Infection and Immunity. 78: 1457-67. PMID 20123719 DOI: 10.1128/IAI.01260-09  1
2010 Anderson GG, Goller CC, Justice S, Hultgren SJ, Seed PC. Polysaccharide capsule and sialic acid-mediated regulation promote biofilm-like intracellular bacterial communities during cystitis Infection and Immunity. 78: 963-975. PMID 20086090 DOI: 10.1128/IAI.00925-09  1
2009 Chen SL, Hung CS, Pinkner JS, Walker JN, Cusumano CK, Li Z, Bouckaert J, Gordon JI, Hultgren SJ. Positive selection identifies an in vivo role for FimH during urinary tract infection in addition to mannose binding. Proceedings of the National Academy of Sciences of the United States of America. 106: 22439-44. PMID 20018753 DOI: 10.1073/pnas.0902179106  1
2009 Cegelski L, Pinkner JS, Hammer ND, Cusumano CK, Hung CS, Chorell E, Aberg V, Walker JN, Seed PC, Almqvist F, Chapman MR, Hultgren SJ. Small-molecule inhibitors target Escherichia coli amyloid biogenesis and biofilm formation. Nature Chemical Biology. 5: 913-9. PMID 19915538 DOI: 10.1038/nchembio.242  1
2009 Cusumano CK, Hultgren SJ. Bacterial adhesion--a source of alternate antibiotic targets. Idrugs : the Investigational Drugs Journal. 12: 699-705. PMID 19844856  1
2009 Waksman G, Hultgren SJ. Structural biology of the chaperone-usher pathway of pilus biogenesis. Nature Reviews. Microbiology. 7: 765-74. PMID 19820722 DOI: 10.1038/nrmicro2220  1
2009 Kostakioti M, Hadjifrangiskou M, Pinkner JS, Hultgren SJ. QseC-mediated dephosphorylation of QseB is required for expression of genes associated with virulence in uropathogenic Escherichia coli. Molecular Microbiology. 73: 1020-31. PMID 19703104 DOI: 10.1111/j.1365-2958.2009.06826.x  1
2009 Hung CS, Dodson KW, Hultgren SJ. A murine model of urinary tract infection. Nature Protocols. 4: 1230-43. PMID 19644462 DOI: 10.1038/nprot.2009.116  1
2009 Guiton PS, Hung CS, Kline KA, Roth R, Kau AL, Hayes E, Heuser J, Dodson KW, Caparon MG, Hultgren SJ. Contribution of autolysin and Sortase a during Enterococcus faecalis DNA-dependent biofilm development. Infection and Immunity. 77: 3626-38. PMID 19528211 DOI: 10.1128/IAI.00219-09  1
2009 Mysorekar IU, Isaacson-Schmid M, Walker JN, Mills JC, Hultgren SJ. Bone morphogenetic protein 4 signaling regulates epithelial renewal in the urinary tract in response to uropathogenic infection. Cell Host & Microbe. 5: 463-75. PMID 19454350 DOI: 10.1016/j.chom.2009.04.005  1
2009 Kline KA, Kau AL, Chen SL, Lim A, Pinkner JS, Rosch J, Nallapareddy SR, Murray BE, Henriques-Normark B, Beatty W, Caparon MG, Hultgren SJ. Mechanism for sortase localization and the role of sortase localization in efficient pilus assembly in Enterococcus faecalis. Journal of Bacteriology. 191: 3237-47. PMID 19286802 DOI: 10.1128/JB.01837-08  1
2009 Henderson JP, Crowley JR, Pinkner JS, Walker JN, Tsukayama P, Stamm WE, Hooton TM, Hultgren SJ. Quantitative metabolomics reveals an epigenetic blueprint for iron acquisition in uropathogenic Escherichia coli. Plos Pathogens. 5: e1000305. PMID 19229321 DOI: 10.1371/journal.ppat.1000305  1
2009 Nenninger AA, Robinson LS, Hultgren SJ. Localized and efficient curli nucleation requires the chaperone-like amyloid assembly protein CsgF. Proceedings of the National Academy of Sciences of the United States of America. 106: 900-5. PMID 19131513 DOI: 10.1073/pnas.0812143106  1
2008 Ingersoll MA, Kline KA, Nielsen HV, Hultgren SJ. G-CSF induction early in uropathogenic Escherichia coli infection of the urinary tract modulates host immunity. Cellular Microbiology. 10: 2568-78. PMID 18754853 DOI: 10.1111/j.1462-5822.2008.01230.x  1
2008 Rosen DA, Hung CS, Kline KA, Hultgren SJ. Streptozocin-induced diabetic mouse model of urinary tract infection. Infection and Immunity. 76: 4290-8. PMID 18644886 DOI: 10.1128/IAI.00255-08  1
2008 Berg V, Das P, Chorell E, Hedenström M, Pinkner JS, Hultgren SJ, Almqvist F. Carboxylic acid isosteres improve the activity of ring-fused 2-pyridones that inhibit pilus biogenesis in E. coli. Bioorganic & Medicinal Chemistry Letters. 18: 3536-40. PMID 18499455 DOI: 10.1016/j.bmcl.2008.05.020  1
2008 Remaut H, Tang C, Henderson NS, Pinkner JS, Wang T, Hultgren SJ, Thanassi DG, Waksman G, Li H. Fiber formation across the bacterial outer membrane by the chaperone/usher pathway. Cell. 133: 640-52. PMID 18485872 DOI: 10.1016/j.cell.2008.03.033  1
2008 Rosen DA, Pinkner JS, Walker JN, Elam JS, Jones JM, Hultgren SJ. Molecular variations in Klebsiella pneumoniae and Escherichia coli FimH affect function and pathogenesis in the urinary tract. Infection and Immunity. 76: 3346-56. PMID 18474655 DOI: 10.1128/IAI.00340-08  1
2008 Rosen DA, Pinkner JS, Jones JM, Walker JN, Clegg S, Hultgren SJ. Utilization of an intracellular bacterial community pathway in Klebsiella pneumoniae urinary tract infection and the effects of FimK on type 1 pilus expression. Infection and Immunity. 76: 3337-45. PMID 18411285 DOI: 10.1128/IAI.00090-08  1
2008 Justice SS, Hunstad DA, Cegelski L, Hultgren SJ. Morphological plasticity as a bacterial survival strategy. Nature Reviews. Microbiology. 6: 162-8. PMID 18157153 DOI: 10.1038/nrmicro1820  1
2008 Cegelski L, Marshall GR, Eldridge GR, Hultgren SJ. The biology and future prospects of antivirulence therapies. Nature Reviews. Microbiology. 6: 17-27. PMID 18079741 DOI: 10.1038/nrmicro1818  1
2008 Hannan TJ, Mysorekar IU, Chen SL, Walker JN, Jones JM, Pinkner JS, Hultgren SJ, Seed PC. LeuX tRNA-dependent and -independent mechanisms of Escherichia coli pathogenesis in acute cystitis. Molecular Microbiology. 67: 116-28. PMID 18036139 DOI: 10.1111/j.1365-2958.2007.06025.x  1
2008 Pemberton N, Pinkner JS, Edvinsson S, Hultgren SJ, Almqvist F. Synthesis and evaluation of dihydroimidazolo and dihydrooxazolo ring-fused 2-pyridones-targeting pilus biogenesis in uropathogenic bacteria Tetrahedron. 64: 9368-9376. DOI: 10.1016/j.tet.2008.07.015  1
2007 Rosen DA, Hooton TM, Stamm WE, Humphrey PA, Hultgren SJ. Detection of intracellular bacterial communities in human urinary tract infection. Plos Medicine. 4: e329. PMID 18092884 DOI: 10.1371/journal.pmed.0040329  1
2007 Verger D, Bullitt E, Hultgren SJ, Waksman G. Crystal structure of the P pilus rod subunit PapA. Plos Pathogens. 3: e73. PMID 17511517 DOI: 10.1371/journal.ppat.0030073  1
2007 Reigstad CS, Hultgren SJ, Gordon JI. Functional genomic studies of uropathogenic Escherichia coli and host urothelial cells when intracellular bacterial communities are assembled. The Journal of Biological Chemistry. 282: 21259-67. PMID 17504765 DOI: 10.1074/jbc.M611502200  1
2007 Lee YM, Dodson KW, Hultgren SJ. Adaptor function of PapF depends on donor strand exchange in P-pilus biogenesis of Escherichia coli. Journal of Bacteriology. 189: 5276-83. PMID 17496084 DOI: 10.1128/JB.01648-06  1
2007 Wright KJ, Seed PC, Hultgren SJ. Development of intracellular bacterial communities of uropathogenic Escherichia coli depends on type 1 pili. Cellular Microbiology. 9: 2230-41. PMID 17490405 DOI: 10.1111/j.1462-5822.2007.00952.x  1
2007 Aberg V, Fällman E, Axner O, Uhlin BE, Hultgren SJ, Almqvist F. Pilicides regulate pili expression in E. coli without affecting the functional properties of the pilus rod. Molecular Biosystems. 3: 214-8. PMID 17308668 DOI: 10.1039/b613441f  1
2007 Garofalo CK, Hooton TM, Martin SM, Stamm WE, Palermo JJ, Gordon JI, Hultgren SJ. Escherichia coli from urine of female patients with urinary tract infections is competent for intracellular bacterial community formation. Infection and Immunity. 75: 52-60. PMID 17074856 DOI: 10.1128/IAI.01123-06  1
2007 Pemberton N, Pinkner JS, Jones JM, Jakobsson L, Hultgren SJ, Almqvist F. Functionalization of bicyclic 2-pyridones targeting pilus biogenesis in uropathogenic Escherichia coli Tetrahedron Letters. 48: 4543-4546. DOI: 10.1016/j.tetlet.2007.04.142  1
2006 Wright KJ, Hultgren SJ. Sticky fibers and uropathogenesis: bacterial adhesins in the urinary tract. Future Microbiology. 1: 75-87. PMID 17661687 DOI: 10.2217/17460913.1.1.75  1
2006 Justice SS, Hunstad DA, Seed PC, Hultgren SJ. Filamentation by Escherichia coli subverts innate defenses during urinary tract infection. Proceedings of the National Academy of Sciences of the United States of America. 103: 19884-9. PMID 17172451 DOI: 10.1073/pnas.0606329104  1
2006 Pinkner JS, Remaut H, Buelens F, Miller E, Aberg V, Pemberton N, Hedenström M, Larsson A, Seed P, Waksman G, Hultgren SJ, Almqvist F. Rationally designed small compounds inhibit pilus biogenesis in uropathogenic bacteria. Proceedings of the National Academy of Sciences of the United States of America. 103: 17897-902. PMID 17098869 DOI: 10.1073/pnas.0606795103  1
2006 Mysorekar IU, Hultgren SJ. Mechanisms of uropathogenic Escherichia coli persistence and eradication from the urinary tract. Proceedings of the National Academy of Sciences of the United States of America. 103: 14170-5. PMID 16968784 DOI: 10.1073/pnas.0602136103  1
2006 Berg V, Sellstedt M, Hedenström M, Pinkner JS, Hultgren SJ, Almqvist F. Design, synthesis and evaluation of peptidomimetics based on substituted bicyclic 2-pyridones-targeting virulence of uropathogenic E. coli. Bioorganic & Medicinal Chemistry. 14: 7563-81. PMID 16904898 DOI: 10.1016/j.bmc.2006.07.017  1
2006 Justice SS, Lauer SR, Hultgren SJ, Hunstad DA. Maturation of intracellular Escherichia coli communities requires SurA. Infection and Immunity. 74: 4793-800. PMID 16861667 DOI: 10.1128/IAI.00355-06  1
2006 Remaut H, Rose RJ, Hannan TJ, Hultgren SJ, Radford SE, Ashcroft AE, Waksman G. Donor-strand exchange in chaperone-assisted pilus assembly proceeds through a concerted beta strand displacement mechanism. Molecular Cell. 22: 831-42. PMID 16793551 DOI: 10.1016/j.molcel.2006.05.033  1
2006 Chen SL, Hung CS, Xu J, Reigstad CS, Magrini V, Sabo A, Blasiar D, Bieri T, Meyer RR, Ozersky P, Armstrong JR, Fulton RS, Latreille JP, Spieth J, Hooton TM, ... ... Hultgren SJ, et al. Identification of genes subject to positive selection in uropathogenic strains of Escherichia coli: a comparative genomics approach. Proceedings of the National Academy of Sciences of the United States of America. 103: 5977-82. PMID 16585510 DOI: 10.1073/pnas.0600938103  1
2006 Bann JG, Cegelski L, Hultgren SJ. LRP6 holds the key to the entry of anthrax toxin. Cell. 124: 1119-21. PMID 16564002 DOI: 10.1016/j.cell.2006.03.007  1
2006 Robinson LS, Ashman EM, Hultgren SJ, Chapman MR. Secretion of curli fibre subunits is mediated by the outer membrane-localized CsgG protein. Molecular Microbiology. 59: 870-81. PMID 16420357 DOI: 10.1111/j.1365-2958.2005.04997.x  1
2005 Meehl MA, Pinkner JS, Anderson PJ, Hultgren SJ, Caparon MG. A novel endogenous inhibitor of the secreted streptococcal NAD-glycohydrolase. Plos Pathogens. 1: e35. PMID 16333395 DOI: 10.1371/journal.ppat.0010035  1
2005 Isaac DD, Pinkner JS, Hultgren SJ, Silhavy TJ. The extracytoplasmic adaptor protein CpxP is degraded with substrate by DegP Proceedings of the National Academy of Sciences of the United States of America. 102: 17775-17779. PMID 16303867 DOI: 10.1073/pnas.0508936102  1
2005 Hedenström M, Emtenäs H, Pemberton N, Aberg V, Hultgren SJ, Pinkner JS, Tegman V, Almqvist F, Sethson I, Kihlberg J. NMR studies of interactions between periplasmic chaperones from uropathogenic E. coli and pilicides that interfere with chaperone function and pilus assembly. Organic & Biomolecular Chemistry. 3: 4193-200. PMID 16294247 DOI: 10.1039/b511857c  1
2005 Justice SS, Hunstad DA, Harper JR, Duguay AR, Pinkner JS, Bann J, Frieden C, Silhavy TJ, Hultgren SJ. Periplasmic peptidyl prolyl cis-trans isomerases are not essential for viability, but SurA is required for pilus biogenesis in Escherichia coli Journal of Bacteriology. 187: 7680-7686. PMID 16267292 DOI: 10.1128/JB.187.22.7680-7686.2005  1
2005 Åberg V, Hedenström M, Pinkner JS, Hultgren SJ, Almqvist F. C-terminal properties are important for ring-fused 2-pyridones that interfere with the chaperone function in uropathogenic E. coli Organic and Biomolecular Chemistry. 3: 3886-3892. PMID 16240004 DOI: 10.1039/b509376g  1
2005 Wright KJ, Seed PC, Hultgren SJ. Uropathogenic Escherichia coli flagella aid in efficient urinary tract colonization. Infection and Immunity. 73: 7657-68. PMID 16239570 DOI: 10.1128/IAI.73.11.7657-7668.2005  1
2005 Hunstad DA, Justice SS, Hung CS, Lauer SR, Hultgren SJ. Suppression of bladder epithelial cytokine responses by uropathogenic Escherichia coli. Infection and Immunity. 73: 3999-4006. PMID 15972487 DOI: 10.1128/IAI.73.7.3999-4006.2005  1
2005 Seed PC, Hultgren SJ. Blueprinting the regulatory response of Escherichia coli to the urinary tract. Trends in Microbiology. 13: 246-8. PMID 15936653 DOI: 10.1016/j.tim.2005.03.014  1
2005 Kau AL, Martin SM, Lyon W, Hayes E, Caparon MG, Hultgren SJ. Enterococcus faecalis tropism for the kidneys in the urinary tract of C57BL/6J mice. Infection and Immunity. 73: 2461-8. PMID 15784592 DOI: 10.1128/IAI.73.4.2461-2468.2005  1
2005 Ohlsson J, Larsson A, Haataja S, Alajääski J, Stenlund P, Pinkner JS, Hultgren SJ, Finne J, Kihlberg J, Nilsson UJ. Structure-activity relationships of galabioside derivatives as inhibitors of E. coli and S. suis adhesins: nanomolar inhibitors of S. suis adhesins. Organic & Biomolecular Chemistry. 3: 886-900. PMID 15731876 DOI: 10.1039/b416878j  1
2005 Larsson A, Johansson SM, Pinkner JS, Hultgren SJ, Almqvist F, Kihlberg J, Linusson A. Multivariate design, synthesis, and biological evaluation of peptide inhibitors of FimC/FimH protein-protein interactions in uropathogenic Escherichia coli. Journal of Medicinal Chemistry. 48: 935-45. PMID 15715464 DOI: 10.1021/jm040818l  1
2005 Kau AL, Hunstad DA, Hultgren SJ. Interaction of uropathogenic Escherichia coli with host uroepithelium. Current Opinion in Microbiology. 8: 54-9. PMID 15694857 DOI: 10.1016/j.mib.2004.12.001  1
2005 Schwan WR, Beck MT, Hultgren SJ, Pinkner J, Woolever NL, Larson T. Down-regulation of the kps region 1 capsular assembly operon following attachment of Escherichia coli type 1 fimbriae to D-mannose receptors. Infection and Immunity. 73: 1226-31. PMID 15664970 DOI: 10.1128/IAI.73.2.1226-1231.2005  1
2005 Bouckaert J, Berglund J, Schembri M, De Genst E, Cools L, Wuhrer M, Hung CS, Pinkner J, Slättegård R, Zavialov A, Choudhury D, Langermann S, Hultgren SJ, Wyns L, Klemm P, et al. Receptor binding studies disclose a novel class of high-affinity inhibitors of the Escherichia coli FimH adhesin. Molecular Microbiology. 55: 441-55. PMID 15659162 DOI: 10.1111/j.1365-2958.2004.04415.x  1
2004 Bann JG, Pinkner JS, Frieden C, Hultgren SJ. Catalysis of protein folding by chaperones in pathogenic bacteria Proceedings of the National Academy of Sciences of the United States of America. 101: 17389-17393. PMID 15583129 DOI: 10.1073/pnas.0408072101  1
2004 Sauer FG, Remaut H, Hultgren SJ, Waksman G. Fiber assembly by the chaperone-usher pathway. Biochimica Et Biophysica Acta. 1694: 259-67. PMID 15546670 DOI: 10.1016/j.bbamcr.2004.02.010  1
2004 Anderson GG, Martin SM, Hultgren SJ. Host subversion by formation of intracellular bacterial communities in the urinary tract. Microbes and Infection / Institut Pasteur. 6: 1094-101. PMID 15380779 DOI: 10.1016/j.micinf.2004.05.023  1
2004 Anderson GG, Dodson KW, Hooton TM, Hultgren SJ. Intracellular bacterial communities of uropathogenic Escherichia coli in urinary tract pathogenesis. Trends in Microbiology. 12: 424-30. PMID 15337164 DOI: 10.1016/j.tim.2004.07.005  1
2004 Bann JG, Hultgren SJ. Structural biology: anthrax hijacks host receptor. Nature. 430: 843-4. PMID 15318206 DOI: 10.1038/430843a  1
2004 Lee YM, DiGiuseppe PA, Silhavy TJ, Hultgren SJ. P pilus assembly motif necessary for activation of the CpxRA pathway by PapE in Escherichia coli Journal of Bacteriology. 186: 4326-4337. PMID 15205435 DOI: 10.1128/JB.186.13.4326-4337.2004  1
2004 Roberts JA, Kaack MB, Baskin G, Chapman MR, Hunstad DA, Pinkner JS, Hultgren SJ. Antibody responses and protection from pyelonephritis following vaccination with purified Escherichia coli PapDG protein. The Journal of Urology. 171: 1682-5. PMID 15017266 DOI: 10.1097/01.ju.0000116123.05160.43  1
2004 Sexton JA, Pinkner JS, Roth R, Heuser JE, Hultgren SJ, Vogel JP. The Legionella pneumophila PilT homologue DotB exhibits ATPase activity that is critical for intracellular growth. Journal of Bacteriology. 186: 1658-66. PMID 14996796 DOI: 10.1128/JB.186.6.1658-1666.2004  1
2004 Bates JM, Raffi HM, Prasadan K, Mascarenhas R, Laszik Z, Maeda N, Hultgren SJ, Kumar S. Tamm-Horsfall protein knockout mice are more prone to urinary tract infection: rapid communication. Kidney International. 65: 791-7. PMID 14871399 DOI: 10.1111/j.1523-1755.2004.00452.x  1
2004 Justice SS, Hung C, Theriot JA, Fletcher DA, Anderson GG, Footer MJ, Hultgren SJ. Differentiation and developmental pathways of uropathogenic Escherichia coli in urinary tract pathogenesis. Proceedings of the National Academy of Sciences of the United States of America. 101: 1333-8. PMID 14739341 DOI: 10.1073/pnas.0308125100  1
2003 Lee YM, Almqvist F, Hultgren SJ. Targeting virulence for antimicrobial chemotherapy. Current Opinion in Pharmacology. 3: 513-9. PMID 14559097 DOI: 10.1016/j.coph.2003.04.001  1
2003 Emtenäs H, Carlsson M, Pinkner JS, Hultgren SJ, Almqvist F. Stereoselective synthesis of optically active bicyclic beta-lactam carboxylic acids that target pilus biogenesis in pathogenic bacteria. Organic & Biomolecular Chemistry. 1: 1308-14. PMID 12929660  1
2003 Anderson GG, Palermo JJ, Schilling JD, Roth R, Heuser J, Hultgren SJ. Intracellular bacterial biofilm-like pods in urinary tract infections. Science (New York, N.Y.). 301: 105-7. PMID 12843396 DOI: 10.1126/science.1084550  1
2003 Larsson A, Ohlsson J, Dodson KW, Hultgren SJ, Nilsson U, Kihlberg J. Quantitative studies of the binding of the class II PapG adhesin from uropathogenic Escherichia coli to oligosaccharides. Bioorganic & Medicinal Chemistry. 11: 2255-61. PMID 12713835 DOI: 10.1016/S0968-0896(03)00114-7  1
2003 Barnhart MM, Sauer FG, Pinkner JS, Hultgren SJ. Chaperone-subunit-usher interactions required for donor strand exchange during bacterial pilus assembly. Journal of Bacteriology. 185: 2723-30. PMID 12700251 DOI: 10.1128/JB.185.9.2723-2730.2003  1
2003 Schilling JD, Martin SM, Hung CS, Lorenz RG, Hultgren SJ. Toll-like receptor 4 on stromal and hematopoietic cells mediates innate resistance to uropathogenic Escherichia coli. Proceedings of the National Academy of Sciences of the United States of America. 100: 4203-8. PMID 12655047 DOI: 10.1073/pnas.0736473100  1
2003 Schilling JD, Martin SM, Hunstad DA, Patel KP, Mulvey MA, Justice SS, Lorenz RG, Hultgren SJ. CD14- and Toll-like receptor-dependent activation of bladder epithelial cells by lipopolysaccharide and type 1 piliated Escherichia coli. Infection and Immunity. 71: 1470-80. PMID 12595465 DOI: 10.1128/IAI.71.3.1470-1480.2003  1
2003 Emtenäs H, Carlsson M, Pinkner JS, Hultgren SJ, Almqvist F. Stereoselective synthesis of optically active bicyclic β-lactam carboxylic acids that target pilus biogenesis in pathogenic bacteria Organic and Biomolecular Chemistry. 1: 1308-1314. DOI: 10.1039/b210551a  1
2002 Schilling JD, Hultgren SJ, Lorenz RG. Recent advances in the molecular basis of pathogen recognition and host responses in the urinary tract. International Reviews of Immunology. 21: 291-304. PMID 12486816 DOI: 10.1080/08830180213275  1
2002 Schilling JD, Lorenz RG, Hultgren SJ. Effect of trimethoprim-sulfamethoxazole on recurrent bacteriuria and bacterial persistence in mice infected with uropathogenic Escherichia coli. Infection and Immunity. 70: 7042-9. PMID 12438384 DOI: 10.1128/IAI.70.12.7042-7049.2002  1
2002 Sauer FG, Pinkner JS, Waksman G, Hultgren SJ. Chaperone priming of pilus subunits facilitates a topological transition that drives fiber formation. Cell. 111: 543-51. PMID 12437927 DOI: 10.1016/S0092-8674(02)01050-4  1
2002 Emtenäs H, Ahlin K, Pinkner JS, Hultgren SJ, Almqvist F. Design and parallel solid-phase synthesis of ring-fused 2-pyridinones that target pilus biogenesis in pathogenic bacteria. Journal of Combinatorial Chemistry. 4: 630-9. PMID 12425608 DOI: 10.1021/cc020032d  1
2002 Thanassi DG, Stathopoulos C, Dodson K, Geiger D, Hultgren SJ. Bacterial outer membrane ushers contain distinct targeting and assembly domains for pilus biogenesis. Journal of Bacteriology. 184: 6260-9. PMID 12399496 DOI: 10.1128/JB.184.22.6260-6269.2002  1
2002 Jones CH, Dexter P, Evans AK, Liu C, Hultgren SJ, Hruby DE. Escherichia coli DegP protease cleaves between paired hydrophobic residues in a natural substrate: the PapA pilin. Journal of Bacteriology. 184: 5762-71. PMID 12270835 DOI: 10.1128/JB.184.20.5762-5771.2002  1
2002 Schilling JD, Hultgren SJ. Recent advances into the pathogenesis of recurrent urinary tract infections: the bladder as a reservoir for uropathogenic Escherichia coli. International Journal of Antimicrobial Agents. 19: 457-60. PMID 12135832 DOI: 10.1016/S0924-8579(02)00098-5  1
2002 Darby C, Hultgren SJ. Innate defense evicts bacterial squatters. Nature Immunology. 3: 602-4. PMID 12087414 DOI: 10.1038/ni0702-602  1
2002 Hung CS, Bouckaert J, Hung D, Pinkner J, Widberg C, DeFusco A, Auguste CG, Strouse R, Langermann S, Waksman G, Hultgren SJ. Structural basis of tropism of Escherichia coli to the bladder during urinary tract infection. Molecular Microbiology. 44: 903-15. PMID 12010488  1
2002 Martinez JJ, Hultgren SJ. Requirement of Rho-family GTPases in the invasion of Type 1-piliated uropathogenic Escherichia coli. Cellular Microbiology. 4: 19-28. PMID 11856170 DOI: 10.1046/j.1462-5822.2002.00166.x  1
2002 Chapman MR, Robinson LS, Pinkner JS, Roth R, Heuser J, Hammar M, Normark S, Hultgren SJ. Role of Escherichia coli curli operons in directing amyloid fiber formation. Science (New York, N.Y.). 295: 851-5. PMID 11823641 DOI: 10.1126/science.1067484  1
2002 Bann JG, Pinkner J, Hultgren SJ, Frieden C. Real-time and equilibrium 19F-NMR studies reveal the role of domain-domain interactions in the folding of the chaperone PapD Proceedings of the National Academy of Sciences of the United States of America. 99: 709-714. PMID 11792867 DOI: 10.1073/pnas.022649599  1
2002 Mysorekar IU, Mulvey MA, Hultgren SJ, Gordon JI. Molecular regulation of urothelial renewal and host defenses during infection with uropathogenic Escherichia coli. The Journal of Biological Chemistry. 277: 7412-9. PMID 11744708 DOI: 10.1074/jbc.M110560200  1
2002 Barnhart MM, Schilling JD, Bäckhed F, Dahlfors AR, Normark S, Hultgren SJ. 7 Host-pathogen interactions: Structure and function of pili Methods in Microbiology. 31: 133-159.  1
2001 Smith CL, Hultgren SJ. Bacteria thread the needle Nature. 414: 29-31. PMID 11689927 DOI: 10.1038/35102139  1
2001 Dodson KW, Pinkner JS, Rose T, Magnusson G, Hultgren SJ, Waksman G. Structural basis of the interaction of the pyelonephritic E. coli adhesin to its human kidney receptor. Cell. 105: 733-43. PMID 11440716 DOI: 10.1016/S0092-8674(01)00388-9  1
2001 Mulvey MA, Schilling JD, Hultgren SJ. Establishment of a persistent Escherichia coli reservoir during the acute phase of a bladder infection. Infection and Immunity. 69: 4572-9. PMID 11402001 DOI: 10.1128/IAI.69.7.4572-4579.2001  1
2001 Hultgren SJ. Uropathogenic escherichia coli: interactions with bladder epithelium Urology. 57: 105-106. PMID 11378067  1
2001 Schilling JD, Mulvey MA, Hultgren SJ. Dynamic interactions between host and pathogen during acute urinary tract infections. Urology. 57: 56-61. PMID 11378051  1
2001 Hung DL, Raivio TL, Jones CH, Silhavy TJ, Hultgren SJ. Cpx signaling pathway monitors biogenesis and affects assembly and expression of P pili Embo Journal. 20: 1508-1518. PMID 11285215 DOI: 10.1093/emboj/20.7.1508  1
2001 Schilling JD, Mulvey MA, Hultgren SJ. Structure and function of Escherichia coli type 1 pili: new insight into the pathogenesis of urinary tract infections. The Journal of Infectious Diseases. 183: S36-40. PMID 11171011 DOI: 10.1086/318855  1
2001 Schilling JD, Mulvey MA, Vincent CD, Lorenz RG, Hultgren SJ. Bacterial invasion augments epithelial cytokine responses to Escherichia coli through a lipopolysaccharide-dependent mechanism. Journal of Immunology (Baltimore, Md. : 1950). 166: 1148-55. PMID 11145696  1
2000 Mahmood A, Engle MJ, Hultgren SJ, Goetz GS, Dodson K, Alpers DH. Role of intestinal surfactant-like particles as a potential reservoir of uropathogenic Escherichia coli Biochimica Et Biophysica Acta - General Subjects. 1523: 49-55. PMID 11099857 DOI: 10.1016/S0304-4165(00)00095-7  1
2000 Sauer FG, Barnhart M, Choudhury D, Knight SD, Waksman G, Hultgren SJ. Chaperone-assisted pilus assembly and bacterial attachment. Current Opinion in Structural Biology. 10: 548-56. PMID 11042452 DOI: 10.1016/S0959-440X(00)00129-9  1
2000 Mulvey MA, Hultgren SJ. Bacterial spelunkers Science. 289: 732-733. PMID 10950716 DOI: 10.1126/science.289.5480.732  1
2000 Mulvey MA, Schilling JD, Martinez JJ, Hultgren SJ. Bad bugs and beleaguered bladders: interplay between uropathogenic Escherichia coli and innate host defenses. Proceedings of the National Academy of Sciences of the United States of America. 97: 8829-35. PMID 10922042 DOI: 10.1073/pnas.97.16.8829  1
2000 Saulino ET, Bullitt E, Hultgren SJ. Snapshots of usher-mediated protein secretion and ordered pilus assembly. Proceedings of the National Academy of Sciences of the United States of America. 97: 9240-5. PMID 10908657 DOI: 10.1073/pnas.160070497  1
2000 Emtenäs H, Soto G, Hultgren SJ, Marshall GR, Almqvist F. Stereoselective synthesis of optically active beta-lactams, potential inhibitors of pilus assembly in pathogenic bacteria. Organic Letters. 2: 2065-7. PMID 10891231  1
2000 Thanassi DG, Hultgren SJ. Multiple pathways allow protein secretion across the bacterial outer membrane Current Opinion in Cell Biology. 12: 420-430. PMID 10873830 DOI: 10.1016/S0955-0674(00)00111-3  1
2000 Barnhart MM, Pinkner JS, Soto GE, Sauer FG, Langermann S, Waksman G, Frieden C, Hultgren SJ. PapD-like chaperones provide the missing information for folding of pilin proteins. Proceedings of the National Academy of Sciences of the United States of America. 97: 7709-14. PMID 10859353 DOI: 10.1073/pnas.130183897  1
2000 Martinez JJ, Mulvey MA, Schilling JD, Pinkner JS, Hultgren SJ. Type 1 pilus-mediated bacterial invasion of bladder epithelial cells. The Embo Journal. 19: 2803-12. PMID 10856226 DOI: 10.1093/emboj/19.12.2803  1
2000 Krasan GP, Sauer FG, Cutter D, Farley MM, Gilsdorf JR, Hultgren SJ, St Geme JW. Evidence for donor strand complementation in the biogenesis of Haemophilus influenzae haemagglutinating pili. Molecular Microbiology. 35: 1335-47. PMID 10760135 DOI: 10.1046/j.1365-2958.2000.01816.x  1
2000 Sauer FG, Knight SD, Waksman and GJ, Hultgren SJ. PapD-like chaperones and pilus biogenesis. Seminars in Cell & Developmental Biology. 11: 27-34. PMID 10736261 DOI: 10.1006/scdb.1999.0348  1
2000 López-Boado YS, Wilson CL, Hooper LV, Gordon JI, Hultgren SJ, Parks WC. Bacterial exposure induces and activates matrilysin in mucosal epithelial cells. The Journal of Cell Biology. 148: 1305-15. PMID 10725342 DOI: 10.1083/jcb.148.6.1305  1
2000 Sauer FG, Mulvey MA, Schilling JD, Martinez JJ, Hultgren SJ. Bacterial pili: molecular mechanisms of pathogenesis. Current Opinion in Microbiology. 3: 65-72. PMID 10679419 DOI: 10.1016/S1369-5274(99)00053-3  1
2000 Langermann S, Möllby R, Burlein JE, Palaszynski SR, Auguste CG, DeFusco A, Strouse R, Schenerman MA, Hultgren SJ, Pinkner JS, Winberg J, Guldevall L, Söderhäll M, Ishikawa K, Normark S, et al. Vaccination with FimH adhesin protects cynomolgus monkeys from colonization and infection by uropathogenic Escherichia coli. The Journal of Infectious Diseases. 181: 774-8. PMID 10669375 DOI: 10.1086/315258  1
2000 Thanassi DG, Hultgren SJ. Assembly of complex organelles: Pilus biogenesis in gram-negative bacteria as a model system Methods. 20: 111-126. PMID 10610809 DOI: 10.1006/meth.1999.0910  1
1999 Goetz GS, Mahmood A, Hultgren SJ, Engle MJ, Dodson K, Alpers DH. Binding of pili from uropathogenic Escherichia coli to membranes secreted by human colonocytes and enterocytes Infection and Immunity. 67: 6161-6163. PMID 10531281  1
1999 Choudhury D, Thompson A, Stojanoff V, Langermann S, Pinkner J, Hultgren SJ, Knight SD. X-ray structure of the FimC-FimH chaperone-adhesin complex from uropathogenic Escherichia coli. Science (New York, N.Y.). 285: 1061-6. PMID 10446051 DOI: 10.1126/science.285.5430.1061  1
1999 Sauer FG, Fütterer K, Pinkner JS, Dodson KW, Hultgren SJ, Waksman G. Structural basis of chaperone function and pilus biogenesis. Science (New York, N.Y.). 285: 1058-61. PMID 10446050 DOI: 10.1126/science.285.5430.1058  1
1999 Hung DL, Pinkner JS, Knight SD, Hultgren SJ. Structural basis of chaperone self-capping in P pilus biogenesis. Proceedings of the National Academy of Sciences of the United States of America. 96: 8178-83. PMID 10393968 DOI: 10.1073/pnas.96.14.8178  1
1999 Hung DL, Knight SD, Hultgren SJ. Probing conserved surfaces on PapD. Molecular Microbiology. 31: 773-83. PMID 10048022 DOI: 10.1046/j.1365-2958.1999.01216.x  1
1999 Soto GE, Hultgren SJ. Bacterial adhesins: common themes and variations in architecture and assembly. Journal of Bacteriology. 181: 1059-71. PMID 9973330  1
1999 Saulino ET, Thanassi DG, Hultgren SJ. Ushers and other doorkeepers: Response Trends in Microbiology. 7: 6-7. DOI: 10.1016/S0966-842X(98)01397-3  1
1998 Thanassi DG, Saulino ET, Hultgren SJ. The chaperone/usher pathway: a major terminal branch of the general secretory pathway. Current Opinion in Microbiology. 1: 223-31. PMID 10066482  1
1998 Hung DL, Hultgren SJ. Pilus biogenesis via the chaperone/usher pathway: An integration of structure and function Journal of Structural Biology. 124: 201-220. PMID 10049807 DOI: 10.1006/jsbi.1998.4049  1
1998 Karlsson KF, Walse B, Drakenberg T, Roy S, Bergquist KE, Pinkner JS, Hultgren SJ, Kihlberg J. Binding of peptides in solution by the Escherichia coli chaperone PapD as revealed using an inhibition ELISA and NMR spectroscopy. Bioorganic & Medicinal Chemistry. 6: 2085-101. PMID 9881099 DOI: 10.1016/S0968-0896(98)00162-X  1
1998 Saulino ET, Thanassi DG, Pinkner JS, Hultgren SJ. Ramifications of kinetic partitioning on usher-mediated pilus biogenesis. The Embo Journal. 17: 2177-85. PMID 9545231 DOI: 10.1093/emboj/17.8.2177  1
1998 Thanassi DG, Saulino ET, Lombardo MJ, Roth R, Heuser J, Hultgren SJ. The PapC usher forms an oligomeric channel: implications for pilus biogenesis across the outer membrane. Proceedings of the National Academy of Sciences of the United States of America. 95: 3146-51. PMID 9501230 DOI: 10.1073/pnas.95.6.3146  1
1998 Almqvist F, Guillaume D, Hultgren SJ, Marshall GR. Efficient regioselective synthesis of enantiomerically pure 4- hydroxymethyl-Δ2-thiazoline Tetrahedron Letters. 39: 2293-2294. DOI: 10.1016/S0040-4039(98)00347-5  1
1997 Jones CH, Danese PN, Pinkner JS, Silhavy TJ, Hultgren SJ. The chaperone-assisted membrane release and folding pathway is sensed by two signal transduction systems. The Embo Journal. 16: 6394-406. PMID 9351822 DOI: 10.1093/emboj/16.21.6394  1
1997 Lopex-Boado YS, Wilson CL, Martinet J, Harnhart M, Hultgren SJ, Parks WC. FimH-dependent bacterial induction of Matrilysin in epithelial cells Faseb Journal. 11.  1
1996 Nilsson U, Striker RT, Hultgren SJ, Magnusson G. PapG adhesin from E. coli J96 recognizes the same saccharide epitope when present on whole bacteria and as isolated protein Bioorganic and Medicinal Chemistry. 4: 1809-1817. PMID 9007266 DOI: 10.1016/S0968-0896(96)00163-0  1
1996 Hung DL, Knight SD, Woods RM, Pinkner JS, Hultgren SJ. Molecular basis of two subfamilies of immunoglobulin-like chaperones. The Embo Journal. 15: 3792-805. PMID 8670884  1
1995 Jones CH, Pinkner JS, Roth R, Heuser J, Nicholes AV, Abraham SN, Hultgren SJ. FimH adhesin of type 1 pili is assembled into a fibrillar tip structure in the Enterobacteriaceae. Proceedings of the National Academy of Sciences of the United States of America. 92: 2081-5. PMID 7892228  1
1995 Magnusson G, Hultgren SJ, Kihlberg J. Specificity mapping of bacterial lectins by inhibition of hemagglutination using deoxy and deoxyfluoro analogs of receptor-active saccharides Methods in Enzymology. 253: 105-114. PMID 7476379 DOI: 10.1016/S0076-6879(95)53012-6  1
1995 Striker R, Nilsson U, Stonecipher A, Magnusson G, Hultgren SJ. Structural requirements for the glycolipid receptor of human uropathogenic Escherichia coli Molecular Microbiology. 16: 1021-1029. PMID 7476178 DOI: 10.1111/j.1365-2958.1995.tb02327.x  1
1995 Xu Z, Jones CH, Haslam D, Pinkner JS, Dodson K, Kihlberg J, Hultgren SJ. Molecular dissection of PapD interaction with PapG reveals two chaperone-binding sites Molecular Microbiology. 16: 1011-1020. PMID 7476177 DOI: 10.1111/j.1365-2958.1995.tb02326.x  1
1995 Flemmer K, Zheng Xu, Pinkner JS, Hultgren SJ, Kihlberg J. Peptides inhibit complexation of the bacterial chaperone papd and reveal potential to block assembly of virulence associated pili Bioorganic and Medicinal Chemistry Letters. 5: 927-932. DOI: 10.1016/0960-894X(95)00145-J  1
1994 Jacob-Dubuisson F, Pinkner J, Xu Z, Striker R, Padmanhaban A, Hultgren SJ. PapD chaperone function in pilus biogenesis depends on oxidant and chaperone-like activities of DsbA Proceedings of the National Academy of Sciences of the United States of America. 91: 11552-11556. PMID 7972100 DOI: 10.1073/pnas.91.24.11552  1
1994 Kuehn MJ, Jacob-Dubuisson F, Dodson K, Slonim L, Striker R, Hultgren SJ. Genetic, biochemical, and structural studies of biogenesis of adhesive pili in bacteria Methods in Enzymology. 236: 282-306. PMID 7968616 DOI: 10.1016/0076-6879(94)36022-7  1
1994 Tewari R, Ikeda T, Malaviya R, MacGregor JI, Little JR, Hultgren SJ, Abraham SN. The PapG tip adhesin of P fimbriae protects Escherichia coli from neutrophil bactericidal activity Infection and Immunity. 62: 5296-5304. PMID 7960108  1
1994 Jacob-Dubuisson F, Striker R, Hultgren SJ. Chaperone-assisted self-assembly of pili independent of cellular energy Journal of Biological Chemistry. 269: 12447-12455. PMID 7909802  1
1994 Striker R, Jacob-Dubuisson F, Frieden C, Hultgren SJ. Stable fiber-forming and nonfiber-forming chaperone-subunit complexes in pilus biogenesis Journal of Biological Chemistry. 269: 12233-12239. PMID 7909317  1
1993 Jones CH, Pinkner JS, Nicholes AV, Slonim LN, Abraham SN, Hultgren SJ. FimC is a periplasmic PapD-like chaperone that directs assembly of type 1 pili in bacteria Proceedings of the National Academy of Sciences of the United States of America. 90: 8397-8401. PMID 8104335  1
1993 Hultgren SJ, Jacob-Dubuisson F, Jones CH, Branden CI. PapD and superfamily of periplasmic immunoglobulin-like pilus chaperones Advances in Protein Chemistry. 44: 99-123. PMID 8100380  1
1993 Hultgren SJ, Abraham S, Caparon M, Falk P, Geme JWS, Normark S. Pilus and nonpilus bacterial adhesins: Assembly and function in cell recognition Cell. 73: 887-901. PMID 8098994 DOI: 10.1016/0092-8674(93)90269-V  1
1993 Dodson KW, Jacob-Dubuisson F, Striker RT, Hultgren SJ. Outer-membrane PapC molecular usher discriminately recognizes periplasmic chaperone-pilus subunit complexes Proceedings of the National Academy of Sciences of the United States of America. 90: 3670-3674. PMID 8097321  1
1993 Tewari R, MacGregor JI, Ikeda T, Little JR, Hultgren SJ, Abraham SN. Neutrophil activation by nascent FimH subunits of type 1 fimbriae purified from the periplasm of Escherichia coli Journal of Biological Chemistry. 268: 3009-3015. PMID 8094080  1
1993 Jacob-Dubuisson F, Kuehn M, Hultgren SJ. A novel secretion apparatus for the assembly of adhesive bacterial pili Trends in Microbiology. 1: 50-55. PMID 7913856 DOI: 10.1016/0966-842X(93)90032-M  1
1993 Kuehn MJ, Ogg DJ, Kihlberg J, Slonim LN, Flemmer K, Bergfors T, Hultgren SJ. Structural basis of pilus subunit recognition by the PapD chaperone Science. 262: 1234-1241. PMID 7901913  1
1992 Slonim LN, Pinkner JS, Branden CI, Hultgren SJ. Interactive surface in the PapD chaperone cleft is conserved in pilus chaperone superfamily and essential in subunit recognition and assembly Embo Journal. 11: 4747-4756. PMID 1361168  1
1992 Holmgren A, Kuehn MJ, Brändén CI, Hultgren SJ. Conserved immunoglobulin-like features in a family of periplasmic pilus chaperdnes in bacteria Embo Journal. 11: 1617-1622. PMID 1348692  1
1992 Kuehn MJ, Heuser J, Normark S, Hultgren SJ. P pili in uropathogenic E. coli are composite fibres with distinct fibrillar adhesive tips Nature. 356: 252-255. PMID 1348107  1
1991 Hultgren SJ, Normark S. Biogenesis of the bacterial pilus Current Opinion in Genetics and Development. 1: 313-318. PMID 1688123 DOI: 10.1016/S0959-437X(05)80293-X  1
1991 Hultgren SJ, Normark S, Abraham SN. Chaperone-assisted assembly and molecular architecture of adhesive pili Annual Review of Microbiology. 45: 383-415. PMID 1683764  1
1991 Kuehn MJ, Normark S, Hultgren SJ. Immunoglobulin-like PapD chaperone caps and uncaps interactive surfaces of nascently translocated pilus subunits Proceedings of the National Academy of Sciences of the United States of America. 88: 10586-10590. PMID 1683704  1
1990 Hultgren SJ, Duncan JL, Schaeffer AJ, Amundsen SK. Mannose-sensitive haemagglutination in the absence of piliation in Escherichia coli Molecular Microbiology. 4: 1311-1318. PMID 1980711  1
1989 Lindberg F, Tennent JM, Hultgren SJ, Lund B, Normark S. PapD, a periplasmic transport protein in P-pilus biogenesis Journal of Bacteriology. 171: 6052-6058. PMID 2572580  1
1989 Hultgren SJ, Lindberg F, Magnusson G, Kihlberg J, Tennent JM, Normark S. The PapG adhesin of uropathogenic Escherichia coli contains separate regions for receptor binding and for the incorporation into the pilus Proceedings of the National Academy of Sciences of the United States of America. 86: 4357-4361. PMID 2567514  1
1989 Kihlberg J, Hultgren SJ, Normark S, Magnusson G. Probing of the combining site of the PapG adhesin of uropathogenic Escherichia coli bacteria by synthetic analogues of galabiose Journal of the American Chemical Society. 111: 6364-6368.  1
1987 Schaeffer AJ, Schwan WR, Hultgren SJ, Duncan JL. Relationship of type 1 pilus expression in Escherichia coli to ascending urinary tract infections in mice Infection and Immunity. 55: 373-380. PMID 2879794  1
1986 Hultgren SJ, Schwan WR, Schaeffer AJ, Duncan JL. Regulation of production of type 1 pili among urinary tract isolates of Escherichia coli Infection and Immunity. 54: 613-620. PMID 2877947  1
1985 Hultgren SJ, Porter TN, Schaeffer AJ, Duncan JL. Role of type 1 pili and effects of phase variation on lower urinary tract infections produced by Escherichia coli. Infection and Immunity. 50: 370-7. PMID 2865209  1
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