Alfred S. Lewin - Publications

Affiliations: 
University of Florida, Gainesville, Gainesville, FL, United States 
Area:
Genetics, Microbiology Biology

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Year Citation  Score
2016 Watson ZL, Ertel MK, Lewin AS, Tuli SS, Schultz GS, Neumann DM, Bloom DC. Adeno-Associated Virus Vectors Efficiently Transduce Mouse and Rabbit Sensory Neurons Co-Infected with HSV-1 Following Peripheral Inoculation. Journal of Virology. PMID 27334582 DOI: 10.1128/JVI.01028-16  0.32
2016 Rex TS, Kasmala L, Bond WS, de Lucas Cerrillo AM, Wynn K, Lewin AS. Erythropoietin Slows Photoreceptor Cell Death in a Mouse Model of Autosomal Dominant Retinitis Pigmentosa. Plos One. 11: e0157411. PMID 27299810 DOI: 10.1371/journal.pone.0157411  0.32
2016 Berkowitz BA, Lewin AS, Biswal MR, Bredell BX, Davis C, Roberts R. MRI of Retinal Free Radical Production With Laminar Resolution In Vivo. Investigative Ophthalmology & Visual Science. 57: 577-85. PMID 26886890 DOI: 10.1167/iovs.15-18972  0.32
2016 Ildefonso CJ, Jaime H, Brown EE, Iwata RL, Ahmed CM, Massengill MT, Biswal MR, Boye SE, Hauswirth WW, Ash JD, Li Q, Lewin AS. Targeting the Nrf2 Signaling Pathway in the Retina With a Gene-Delivered Secretable and Cell-Penetrating Peptide. Investigative Ophthalmology & Visual Science. 57: 372-86. PMID 26842755 DOI: 10.1167/iovs.15-17703  0.32
2016 Conley SM, Whalen P, Lewin AS, Naash MI. Characterization of Ribozymes Targeting a Congenital Night Blindness Mutation in Rhodopsin Mutation. Advances in Experimental Medicine and Biology. 854: 509-15. PMID 26427453 DOI: 10.1007/978-3-319-17121-0_68  0.32
2016 Chiang WC, Joseph V, Yasumura D, Matthes MT, Lewin AS, Gorbatyuk MS, Ahern K, LaVail MM, Lin JH. Ablation of Chop Transiently Enhances Photoreceptor Survival but Does Not Prevent Retinal Degeneration in Transgenic Mice Expressing Human P23H Rhodopsin. Advances in Experimental Medicine and Biology. 854: 185-91. PMID 26427410 DOI: 10.1007/978-3-319-17121-0_25  0.32
2016 Ildefonso CJ, Biswal MR, Ahmed CM, Lewin AS. The NLRP3 Inflammasome and its Role in Age-Related Macular Degeneration. Advances in Experimental Medicine and Biology. 854: 59-65. PMID 26427394 DOI: 10.1007/978-3-319-17121-0_9  0.32
2016 Biswal MR, Ildefonso CJ, Mao H, Seo SJ, Wang Z, Li H, Le YZ, Lewin AS. Conditional Induction of Oxidative Stress in RPE: A Mouse Model of Progressive Retinal Degeneration. Advances in Experimental Medicine and Biology. 854: 31-7. PMID 26427390 DOI: 10.1007/978-3-319-17121-0_5  0.32
2016 Ahmed CM, Biswal MR, Li H, Han P, Ildefonso CJ, Lewin AS. Repurposing an orally available drug for the treatment of geographic atrophy Molecular Vision. 22: 294-310.  0.32
2015 Beltran WA, Cideciyan AV, Iwabe S, Swider M, Kosyk MS, McDaid K, Martynyuk I, Ying GS, Shaffer J, Deng WT, Boye SL, Lewin AS, Hauswirth WW, Jacobson SG, Aguirre GD. Successful arrest of photoreceptor and vision loss expands the therapeutic window of retinal gene therapy to later stages of disease. Proceedings of the National Academy of Sciences of the United States of America. 112: E5844-53. PMID 26460017 DOI: 10.1073/pnas.1509914112  0.32
2015 Yu H, Koilkonda RD, Chou TH, Porciatti V, Mehta A, Hentall ID, Chiodo VA, Boye SL, Hauswirth WW, Lewin AS, Guy J. Consequences of zygote injection and germline transfer of mutant human mitochondrial DNA in mice. Proceedings of the National Academy of Sciences of the United States of America. PMID 26438859 DOI: 10.1073/pnas.1506129112  0.32
2015 Soustek MS, Baligand C, Falk DJ, Walter GA, Lewin AS, Byrne BJ. Endurance training ameliorates complex 3 deficiency in a mouse model of Barth syndrome. Journal of Inherited Metabolic Disease. PMID 25860817 DOI: 10.1007/s10545-015-9834-8  0.32
2015 Ildefonso CJ, Jaime H, Biswal MR, Boye SE, Li Q, Hauswirth WW, Lewin AS. Gene therapy with the caspase activation and recruitment domain reduces the ocular inflammatory response. Molecular Therapy : the Journal of the American Society of Gene Therapy. 23: 875-84. PMID 25698151 DOI: 10.1038/mt.2015.30  0.32
2015 Rossmiller BP, Ryals RC, Lewin AS. Gene therapy to rescue retinal degeneration caused by mutations in rhodopsin. Methods in Molecular Biology (Clifton, N.J.). 1271: 391-410. PMID 25697537 DOI: 10.1007/978-1-4939-2330-4_25  0.32
2015 Ildefonso CJ, Jaime H, Rahman MM, Li Q, Boye SE, Hauswirth WW, Lucas AR, McFadden G, Lewin AS. Gene delivery of a viral anti-inflammatory protein to combat ocular inflammation. Human Gene Therapy. 26: 59-68. PMID 25420215 DOI: 10.1089/hum.2014.089  0.32
2015 Beltran WA, Cideciyan AV, Lewin AS, Hauswirth WW, Jacobson SG, Aguirre GD. Gene augmentation for X-linked retinitis pigmentosa caused by mutations in RPGR. Cold Spring Harbor Perspectives in Medicine. 5: a017392. PMID 25301933 DOI: 10.1101/cshperspect.a017392  0.32
2015 Biswal MR, Ahmed CM, Ildefonso CJ, Han P, Li H, Jivanji H, Mao H, Lewin AS. Systemic treatment with a 5HT1a agonist induces anti-oxidant protection and preserves the retina from mitochondrial oxidative stress Experimental Eye Research. 140: 94-105. DOI: 10.1016/j.exer.2015.07.022  0.32
2015 Robinson PM, Kim SS, Sriram S, Tuli S, Hauswirth WW, Lewin AS, Schultz GS. Reduction of Profibrotic Connective Tissue Growth Factor in Wounded Rat Corneas Using a Ribozyme Expressed in Self Complimentary Adeno-Associated Virus Wound Healing: Cellular Mechanisms, Alternative Therapies and Clinical Outcomes. 25-42.  0.32
2014 Koilkonda R, Yu H, Talla V, Porciatti V, Feuer WJ, Hauswirth WW, Chiodo V, Erger KE, Boye SL, Lewin AS, Conlon TJ, Renner L, Neuringer M, Detrisac C, Guy J. LHON gene therapy vector prevents visual loss and optic neuropathy induced by G11778A mutant mitochondrial DNA: biodistribution and toxicology profile. Investigative Ophthalmology & Visual Science. 55: 7739-53. PMID 25342621 DOI: 10.1167/iovs.14-15388  0.32
2014 Mao H, Seo SJ, Biswal MR, Li H, Conners M, Nandyala A, Jones K, Le YZ, Lewin AS. Mitochondrial oxidative stress in the retinal pigment epithelium leads to localized retinal degeneration. Investigative Ophthalmology & Visual Science. 55: 4613-27. PMID 24985474 DOI: 10.1167/iovs.14-14633  0.32
2014 Sriram S, Gibson DJ, Robinson P, Pi L, Tuli S, Lewin AS, Schultz G. Assessment of anti-scarring therapies in ex vivo organ cultured rabbit corneas. Experimental Eye Research. 125: 173-82. PMID 24971495 DOI: 10.1016/j.exer.2014.06.014  0.32
2014 Rowe-Rendleman CL, Durazo SA, Kompella UB, Rittenhouse KD, Di Polo A, Weiner AL, Grossniklaus HE, Naash MI, Lewin AS, Horsager A, Edelhauser HF. Drug and gene delivery to the back of the eye: from bench to bedside. Investigative Ophthalmology & Visual Science. 55: 2714-30. PMID 24777644 DOI: 10.1167/iovs.13-13707  0.32
2014 Choudhury S, Nashine S, Bhootada Y, Kunte MM, Gorbatyuk O, Lewin AS, Gorbatyuk M. Modulation of the rate of retinal degeneration in T17M RHO mice by reprogramming the unfolded protein response. Advances in Experimental Medicine and Biology. 801: 455-62. PMID 24664731 DOI: 10.1007/978-1-4614-3209-8_58  0.32
2014 Koilkonda RD, Yu H, Chou TH, Feuer WJ, Ruggeri M, Porciatti V, Tse D, Hauswirth WW, Chiodo V, Boye SL, Lewin AS, Neuringer M, Renner L, Guy J. Safety and effects of the vector for the Leber hereditary optic neuropathy gene therapy clinical trial. Jama Ophthalmology. 132: 409-20. PMID 24457989 DOI: 10.1001/jamaophthalmol.2013.7630  0.32
2014 Lewin AS, Rossmiller B, Mao H. Gene augmentation for adRP mutations in RHO Cold Spring Harbor Perspectives in Medicine. 4. DOI: 10.1101/cshperspect.a017400  0.32
2013 Sriram S, Robinson P, Pi L, Lewin AS, Schultz G. Triple combination of siRNAs targeting TGFβ1, TGFβR2, and CTGF enhances reduction of collagen I and smooth muscle actin in corneal fibroblasts. Investigative Ophthalmology & Visual Science. 54: 8214-23. PMID 24282226 DOI: 10.1167/iovs.13-12758  0.32
2013 Wang R, Mason DE, Choe KP, Lewin AS, Peters EC, Luesch H. In vitro and in vivo characterization of a tunable dual-reactivity probe of the Nrf2-ARE pathway Acs Chemical Biology. 8: 1764-1774. PMID 23773140 DOI: 10.1021/cb4000103  0.32
2013 Talla V, Yu H, Chou TH, Porciatti V, Chiodo V, Boye SL, Hauswirth WW, Lewin AS, Guy J. NADH-dehydrogenase type-2 suppresses irreversible visual loss and neurodegeneration in the EAE animal model of MS. Molecular Therapy : the Journal of the American Society of Gene Therapy. 21: 1876-88. PMID 23752309 DOI: 10.1038/mt.2013.104  0.32
2013 Nashine S, Bhootada Y, Lewin AS, Gorbatyuk M. Ablation of C/EBP Homologous Protein Does Not Protect T17M RHO Mice from Retinal Degeneration Plos One. 8. PMID 23646198 DOI: 10.1371/journal.pone.0063205  0.32
2013 Boye SE, Boye SL, Lewin AS, Hauswirth WW. A comprehensive review of retinal gene therapy. Molecular Therapy : the Journal of the American Society of Gene Therapy. 21: 509-19. PMID 23358189 DOI: 10.1038/mt.2012.280  0.32
2012 Robinson PM, Smith TS, Patel D, Dave M, Lewin AS, Pi L, Scott EW, Tuli SS, Schultz GS. Proteolytic processing of connective tissue growth factor in normal ocular tissues and during corneal wound healing. Investigative Ophthalmology & Visual Science. 53: 8093-103. PMID 23139278 DOI: 10.1167/iovs.12-10419  0.32
2012 Rossmiller B, Mao H, Lewin AS. Review: Gene therapy in animal models of autosomal dominant retinitis pigmentosa Molecular Vision. 18: 2479-2496. PMID 23077406  0.32
2012 Yu H, Ozdemir SS, Koilkonda RD, Chou TH, Porciatti V, Chiodo V, Boye SL, Hauswirth WW, Lewin AS, Guy J. Mutant NADH dehydrogenase subunit 4 gene delivery to mitochondria by targeting sequence-modified adeno-associated virus induces visual loss and optic atrophy in mice. Molecular Vision. 18: 1668-83. PMID 22773905  0.32
2012 Seo SJ, Krebs MP, Mao H, Jones K, Conners M, Lewin AS. Pathological consequences of long-term mitochondrial oxidative stress in the mouse retinal pigment epithelium. Experimental Eye Research. 101: 60-71. PMID 22687918 DOI: 10.1016/j.exer.2012.05.013  0.32
2012 Yu H, Koilkonda RD, Chou TH, Porciatti V, Ozdemir SS, Chiodo V, Boye SL, Boye SE, Hauswirth WW, Lewin AS, Guy J. Gene delivery to mitochondria by targeting modified adenoassociated virus suppresses Leber's hereditary optic neuropathy in a mouse model. Proceedings of the National Academy of Sciences of the United States of America. 109: E1238-47. PMID 22523243 DOI: 10.1073/pnas.1119577109  0.32
2012 Thampi P, Rao HV, Mitter SK, Cai J, Mao H, Li H, Seo S, Qi X, Lewin AS, Romano C, Boulton ME. The 5HT1a receptor agonist 8-Oh DPAT induces protection from lipofuscin accumulation and oxidative stress in the retinal pigment epithelium. Plos One. 7: e34468. PMID 22509307 DOI: 10.1371/journal.pone.0034468  0.32
2012 Gorbatyuk MS, Shabashvili A, Chen W, Meyers C, Sullivan LF, Salganik M, Lin JH, Lewin AS, Muzyczka N, Gorbatyuk OS. Glucose regulated protein 78 diminishes α-synuclein neurotoxicity in a rat model of Parkinson disease. Molecular Therapy : the Journal of the American Society of Gene Therapy. 20: 1327-37. PMID 22434142 DOI: 10.1038/mt.2012.28  0.32
2012 Beltran WA, Cideciyan AV, Lewin AS, Iwabe S, Khanna H, Sumaroka A, Chiodo VA, Fajardo DS, Román AJ, Deng WT, Swider M, Alemán TS, Boye SL, Genini S, Swaroop A, et al. Gene therapy rescues photoreceptor blindness in dogs and paves the way for treating human X-linked retinitis pigmentosa. Proceedings of the National Academy of Sciences of the United States of America. 109: 2132-7. PMID 22308428 DOI: 10.1073/pnas.1118847109  0.32
2012 Mao H, Gorbatyuk MS, Rossmiller B, Hauswirth WW, Lewin AS. Long-term rescue of retinal structure and function by rhodopsin RNA replacement with a single adeno-associated viral vector in P23H RHO transgenic mice. Human Gene Therapy. 23: 356-66. PMID 22289036 DOI: 10.1089/hum.2011.213  0.32
2012 Petrs-Silva H, Yasumura D, Matthes MT, LaVail MM, Lewin AS, Hauswirth WW. Suppression of rds expression by siRNA and gene replacement strategies for gene therapy using rAAV vector. Advances in Experimental Medicine and Biology. 723: 215-23. PMID 22183336 DOI: 10.1007/978-1-4614-0631-0_29  0.32
2012 Mao H, Gorbatyuk MS, Hauswirth WW, Lewin AS. Gene delivery of wild-type rhodopsin rescues retinal function in an autosomal dominant retinitis pigmentosa mouse model. Advances in Experimental Medicine and Biology. 723: 199-205. PMID 22183334 DOI: 10.1007/978-1-4614-0631-0_27  0.32
2012 Gorbatyuk MS, Gorbatyuk OS, LaVail MM, Lin JH, Hauswirth WW, Lewin AS. Functional rescue of P23H rhodopsin photoreceptors by gene delivery. Advances in Experimental Medicine and Biology. 723: 191-7. PMID 22183333 DOI: 10.1007/978-1-4614-0631-0_26  0.32
2012 Robinson PM, Blalock TD, Yuan R, Lewin AS, Schultz GS. Hammerhead ribozyme-mediated knockdown of mRNA for fibrotic growth factors: transforming growth factor-beta 1 and connective tissue growth factor. Methods in Molecular Biology (Clifton, N.J.). 820: 117-32. PMID 22131029 DOI: 10.1007/978-1-61779-439-1_8  0.32
2012 Verma A, Shan Z, Lei B, Yuan L, Liu X, Nakagawa T, Grant MB, Lewin AS, Hauswirth WW, Raizada MK, Li Q. ACE2 and Ang-(1-7) confer protection against development of diabetic retinopathy. Molecular Therapy : the Journal of the American Society of Gene Therapy. 20: 28-36. PMID 21792177 DOI: 10.1038/mt.2011.155  0.32
2011 Mao H, James T, Schwein A, Shabashvili AE, Hauswirth WW, Gorbatyuk MS, Lewin AS. AAV delivery of wild-type rhodopsin preserves retinal function in a mouse model of autosomal dominant retinitis pigmentosa. Human Gene Therapy. 22: 567-75. PMID 21126223 DOI: 10.1089/hum.2010.140  0.32
2011 Soustek MS, Falk DJ, Mah CS, Toth MJ, Schlame M, Lewin AS, Byrne BJ. Characterization of a transgenic short hairpin RNA-induced murine model of Tafazzin deficiency. Human Gene Therapy. 22: 865-71. PMID 21091282 DOI: 10.1089/hum.2010.199  0.32
2011 Petrs-Silva H, Dinculescu A, Li Q, Deng WT, Pang JJ, Min SH, Chiodo V, Neeley AW, Govindasamy L, Bennett A, Agbandje-McKenna M, Zhong L, Li B, Jayandharan GR, Srivastava A, ... Lewin AS, et al. Novel properties of tyrosine-mutant AAV2 vectors in the mouse retina. Molecular Therapy : the Journal of the American Society of Gene Therapy. 19: 293-301. PMID 21045809 DOI: 10.1038/mt.2010.234  0.32
2010 Jarrett SG, Lewin AS, Boulton ME. The importance of Mitochondria in age-related and inherited eye disorders Ophthalmic Research. 44: 179-190. PMID 20829642 DOI: 10.1159/000316480  0.32
2010 Gorbatyuk OS, Li S, Nash K, Gorbatyuk M, Lewin AS, Sullivan LF, Mandel RJ, Chen W, Meyers C, Manfredsson FP, Muzyczka N. In vivo RNAi-mediated alpha-synuclein silencing induces nigrostriatal degeneration. Molecular Therapy : the Journal of the American Society of Gene Therapy. 18: 1450-7. PMID 20551914 DOI: 10.1038/mt.2010.115  0.32
2010 Beltran WA, Boye SL, Boye SE, Chiodo VA, Lewin AS, Hauswirth WW, Aguirre GD. rAAV2/5 gene-targeting to rods:dose-dependent efficiency and complications associated with different promoters. Gene Therapy. 17: 1162-74. PMID 20428215 DOI: 10.1038/gt.2010.56  0.32
2010 Gorbatyuk MS, Knox T, LaVail MM, Gorbatyuk OS, Noorwez SM, Hauswirth WW, Lin JH, Muzyczka N, Lewin AS. Restoration of visual function in P23H rhodopsin transgenic rats by gene delivery of BiP/Grp78. Proceedings of the National Academy of Sciences of the United States of America. 107: 5961-6. PMID 20231467 DOI: 10.1073/pnas.0911991107  0.32
2009 Manfredsson FP, Burger C, Rising AC, Zuobi-Hasona K, Sullivan LF, Lewin AS, Huang J, Piercefield E, Muzyczka N, Mandel RJ. Tight Long-term dynamic doxycycline responsive nigrostriatal GDNF using a single rAAV vector. Molecular Therapy : the Journal of the American Society of Gene Therapy. 17: 1857-67. PMID 19707186 DOI: 10.1038/mt.2009.196  0.32
2009 Chen B, Caballero S, Seo S, Grant MB, Lewin AS. Delivery of antioxidant enzyme genes to protect against ischemia/reperfusion-induced injury to retinal microvasculature. Investigative Ophthalmology & Visual Science. 50: 5587-95. PMID 19628743 DOI: 10.1167/iovs.09-3633  0.32
2009 Guy J, Qi X, Koilkonda RD, Arguello T, Chou TH, Ruggeri M, Porciatti V, Lewin AS, Hauswirth WW. Efficiency and safety of AAV-mediated gene delivery of the human ND4 complex I subunit in the mouse visual system. Investigative Ophthalmology & Visual Science. 50: 4205-14. PMID 19387075 DOI: 10.1167/iovs.08-3214  0.32
2009 Petrs-Silva H, Dinculescu A, Li Q, Min SH, Chiodo V, Pang JJ, Zhong L, Zolotukhin S, Srivastava A, Lewin AS, Hauswirth WW. High-efficiency transduction of the mouse retina by tyrosine-mutant AAV serotype vectors. Molecular Therapy : the Journal of the American Society of Gene Therapy. 17: 463-71. PMID 19066593 DOI: 10.1038/mt.2008.269  0.32
2008 Liu J, Saghizadeh M, Tuli SS, Kramerov AA, Lewin AS, Bloom DC, Hauswirth WW, Castro MG, Schultz GS, Ljubimov AV. Different tropism of adenoviruses and adeno-associated viruses to corneal cells: implications for corneal gene therapy. Molecular Vision. 14: 2087-96. PMID 19023450  0.32
2008 Li Q, Dinculescu A, Shan Z, Miller R, Pang J, Lewin AS, Raizada MK, Hauswirth WW. Downregulation of p22phox in retinal pigment epithelial cells inhibits choroidal neovascularization in mice Molecular Therapy. 16: 1688-1694. PMID 18665154 DOI: 10.1038/mt.2008.164  0.32
2008 Liu J, Lewin AS, Tuli SS, Ghivizzani SC, Schultz GS, Bloom DC. Reduction in severity of a herpes simplex virus type 1 murine infection by treatment with a ribozyme targeting the UL20 gene RNA Journal of Virology. 82: 7467-7474. PMID 18508896 DOI: 10.1128/JVI.02720-07  0.32
2008 Chakraborty D, Whalen P, Lewin AS, Naash MI. In vitro analysis of ribozyme-mediated knockdown of an ADRP associated rhodopsin mutation. Advances in Experimental Medicine and Biology. 613: 97-106. PMID 18188933 DOI: 10.1007/978-0-387-74904-4_10  0.32
2008 Denovan-Wright EM, Rodriguez-Lebron E, Lewin AS, Mandel RJ. Unexpected off-targeting effects of anti-huntingtin ribozymes and siRNA in vivo. Neurobiology of Disease. 29: 446-55. PMID 18166484 DOI: 10.1016/j.nbd.2007.11.003  0.32
2008 Andino LM, Takeda M, Kasahara H, Jakymiw A, Byrne BJ, Lewin AS. AAV-mediated knockdown of phospholamban leads to improved contractility and calcium handling in cardiomyocytes. The Journal of Gene Medicine. 10: 132-42. PMID 18064719 DOI: 10.1002/jgm.1131  0.32
2008 Gorbatyuk MS, Hauswirth WW, Lewin AS. Gene therapy for mouse models of adrp Advances in Experimental Medicine and Biology. 613: 107-112. DOI: 10.1007/978-0-387-74904-4_11  0.32
2007 Andino LM, Conlon TJ, Porvasnik SL, Boye SL, Hauswirth WW, Lewin AS. Rapid, widespread transduction of the murine myocardium using self-complementary Adeno-associated virus. Genetic Vaccines and Therapy. 5: 13. PMID 18070352 DOI: 10.1186/1479-0556-5-13  0.32
2007 Qi X, Sun L, Lewin AS, Hauswirth WW, Guy J. Long-term suppression of neurodegeneration in chronic experimental optic neuritis: Antioxidant gene therapy Investigative Ophthalmology and Visual Science. 48: 5360-5370. PMID 18055782 DOI: 10.1167/iovs.07-0254  0.32
2007 Justilien V, Pang JJ, Renganathan K, Zhan X, Crabb JW, Kim SR, Sparrow JR, Hauswirth WW, Lewin AS. SOD2 knockdown mouse model of early AMD. Investigative Ophthalmology & Visual Science. 48: 4407-20. PMID 17898259 DOI: 10.1167/iovs.07-0432  0.32
2007 Manfredsson FP, Burger C, Sullivan LF, Muzyczka N, Lewin AS, Mandel RJ. rAAV-mediated nigral human parkin over-expression partially ameliorates motor deficits via enhanced dopamine neurotransmission in a rat model of Parkinson's disease. Experimental Neurology. 207: 289-301. PMID 17678648 DOI: 10.1016/j.expneurol.2007.06.019  0.32
2007 Aarnisalo AA, Pietola L, Joensuu J, Isosomppi J, Aarnisalo P, Dinculescu A, Lewin AS, Flannery J, Hauswirth WW, Sankila EM, Jero J. Anti-clarin-1 AAV-delivered ribozyme induced apoptosis in the mouse cochlea Hearing Research. 230: 9-16. PMID 17493778 DOI: 10.1016/j.heares.2007.03.004  0.32
2007 White DA, Fritz JJ, Hauswirth WW, Kaushal S, Lewin AS. Increased sensitivity to light-induced damage in a mouse model of autosomal dominant retinal disease. Investigative Ophthalmology & Visual Science. 48: 1942-51. PMID 17460245 DOI: 10.1167/iovs.06-1131  0.32
2007 Han Z, Gorbatyuk M, Thomas J, Lewin AS, Srivastava A, Stacpoole PW. Down-regulation of expression of rat pyruvate dehydrogenase E1alpha gene by self-complementary adeno-associated virus-mediated small interfering RNA delivery. Mitochondrion. 7: 253-9. PMID 17392036 DOI: 10.1016/j.mito.2007.02.003  0.32
2007 Qi X, Sun L, Hauswirth WW, Lewin AS, Guy J. Use of mitochondrial antioxidant defenses for rescue of cells with a leber hereditary optic neuropathy-causing mutation Archives of Ophthalmology. 125: 268-272. PMID 17296905 DOI: 10.1001/archopht.125.2.268  0.32
2007 Gorbatyuk M, Justilien V, Liu J, Hauswirth WW, Lewin AS. Suppression of mouse rhodopsin expression in vivo by AAV mediated siRNA delivery Vision Research. 47: 1202-1208. PMID 17292939 DOI: 10.1016/j.visres.2006.11.026  0.32
2007 Qi X, Lewin AS, Sun L, Hauswirth WW, Guy J. Suppression of mitochondrial oxidative stress provides long-term neuroprotection in experimental optic neuritis Investigative Ophthalmology and Visual Science. 48: 681-691. PMID 17251466 DOI: 10.1167/iovs.06-0553  0.32
2007 Qi X, Sun L, Lewin AS, Hauswirth WW, Guy J. The mutant human ND4 subunit of complex I induces optic neuropathy in the mouse Investigative Ophthalmology and Visual Science. 48: 1-10. PMID 17197509 DOI: 10.1167/iovs.06-0789  0.32
2007 Gorbatyuk M, Justilien V, Liu J, Hauswirth WW, Lewin AS. Preservation of photoreceptor morphology and function in P23H rats using an allele independent ribozyme Experimental Eye Research. 84: 44-52. PMID 17083931 DOI: 10.1016/j.exer.2006.08.014  0.32
2006 Qi X, Lewin AS, Sun L, Hauswirth WW, Guy J. Mitochondrial protein nitration primes neurodegeneration in experimental autoimmune encephalomyelitis Journal of Biological Chemistry. 281: 31950-31962. PMID 16920708 DOI: 10.1074/jbc.M603717200  0.32
2006 Manfredsson FP, Lewin AS, Mandel RJ. RNA knockdown as a potential therapeutic strategy in Parkinson's disease. Gene Therapy. 13: 517-24. PMID 16267570 DOI: 10.1038/sj.gt.3302669  0.32
2005 Teusner JT, Lewin AS, Hauswirth WW. Down-regulation of rhodopsin gene expression by AAV-vectored short interfering RNA Advances in Experimental Medicine and Biology. 572: 233-238. PMID 17249579  0.32
2005 Lewin AS, Glazer PM, Milstone LM. Gene therapy for autosomal dominant disorders of keratin. The Journal of Investigative Dermatology. Symposium Proceedings / the Society For Investigative Dermatology, Inc. [and] European Society For Dermatological Research. 10: 47-61. PMID 16250209 DOI: 10.1111/j.1087-0024.2005.10207.x  0.32
2005 Liu J, Timmers AM, Lewin AS, Hauswirth WW. Ribozyme knockdown of the gamma-subunit of rod cGMP phosphodiesterase alters the ERG and retinal morphology in wild-type mice. Investigative Ophthalmology & Visual Science. 46: 3836-44. PMID 16186371 DOI: 10.1167/iovs.04-1283  0.32
2005 Gorbatyuk MS, Pang JJ, Thomas J, Hauswirth WW, Lewin AS. Knockdown of wild-type mouse rhodopsin using an AAV vectored ribozyme as part of an RNA replacement approach Molecular Vision. 11: 648-656. PMID 16145542  0.32
2005 Rodriguez-Lebron E, Denovan-Wright EM, Nash K, Lewin AS, Mandel RJ. Intrastriatal rAAV-mediated delivery of anti-huntingtin shRNAs induces partial reversal of disease progression in R6/1 Huntington's disease transgenic mice. Molecular Therapy : the Journal of the American Society of Gene Therapy. 12: 618-33. PMID 16019264 DOI: 10.1016/j.ymthe.2005.05.006  0.32
2004 Qi X, Lewin AS, Sun L, Hauswirth WW, Guy J. SOD2 gene transfer protects against optic neuropathy induced by deficiency of complex I Annals of Neurology. 56: 182-191. PMID 15293270 DOI: 10.1002/ana.20175  0.32
2004 Blalock TD, Yuan R, Lewin AS, Schultz GS. Hammerhead ribozyme targeting connective tissue growth factor mRNA blocks transforming growth factor-beta mediated cell proliferation. Experimental Eye Research. 78: 1127-36. PMID 15109919 DOI: 10.1016/j.exer.2004.01.012  0.32
2004 Fritz JJ, Gorbatyuk M, Lewin AS, Hauswirth WW. Design and validation of therapeutic hammerhead ribozymes for autosomal dominant diseases. Methods in Molecular Biology (Clifton, N.J.). 252: 221-36. PMID 15017052 DOI: 10.1385/1-59259-746-7:221  0.32
2004 Hauswirth WW, Li Q, Raisler B, Timmers AM, Berns KI, Flannery JG, LaVail MM, Lewin AS. Range of retinal diseases potentially treatable by AAV-vectored gene therapy. Novartis Foundation Symposium. 255: 179-88; discussion 1. PMID 14750604  0.32
2003 Shaw LC, Afzal A, Lewin AS, Timmers AM, Spoerri PE, Grant MB. Decreased expression of the insulin-like growth factor 1 receptor by ribozyme cleavage Investigative Ophthalmology and Visual Science. 44: 4105-4113. PMID 12939334 DOI: 10.1167/iovs.03-0295  0.32
2003 Afzal A, Shaw LC, Caballero S, Spoerri PE, Lewin AS, Zeng D, Belardinelli L, Grant MB. Reduction in preretinal neovascularization by ribozymes that cleave the A2B adenosine receptor mRNA Circulation Research. 93: 500-506. PMID 12919950 DOI: 10.1161/01.RES.0000091260.78959.BC  0.32
2003 Qi X, Lewin AS, Hauswirth WW, Guy J. Optic neuropathy induced by reductions in mitochondrial superoxide dismutase Investigative Ophthalmology and Visual Science. 44: 1088-1096. PMID 12601034 DOI: 10.1167/iovs.02-0864  0.32
2003 Qi X, Lewin AS, Hauswirth WW, Guy J. Suppression of complex I gene expression induces optic neuropathy Annals of Neurology. 53: 198-205. PMID 12557286 DOI: 10.1002/ana.10426  0.32
2002 Guy J, Qi X, Pallotti F, Schon EA, Manfredi G, Carelli V, Martinuzzi A, Hauswirth WW, Lewin AS. Rescue of a mitochondrial deficiency causing Leber Hereditary Optic Neuropathy. Annals of Neurology. 52: 534-42. PMID 12402249 DOI: 10.1002/ana.10354  0.32
2002 Fritz JJ, White DA, Lewin AS, Hauswirth WW. Designing and characterizing hammerhead ribozymes for use in AAV vector-mediated retinal gene therapies Methods in Enzymology. 346: 358-377. DOI: 10.1016/S0076-6879(02)46066-1  0.32
2001 Li Q, Timmers AM, Hunter K, Gonzalez-Pola C, Lewin AS, Reitze DH, Hauswirth WW. Noninvasive imaging by optical coherence tomography to monitor retinal degeneration in the mouse Investigative Ophthalmology and Visual Science. 42: 2981-2989. PMID 11687546  0.32
2001 Lewin AS, Hauswirth WW. Ribozyme gene therapy: Applications for molecular medicine Trends in Molecular Medicine. 7: 221-228. PMID 11325634 DOI: 10.1016/S1471-4914(01)01965-7  0.32
2001 Shaw LC, Skold A, Wong F, Petters R, Hauswirth W, Lewin AS. An Allele-specific hammerhead ribozyme gene therapy for a porcine model of autosomal dominant retinitis pigmentosa Molecular Vision. 7: 6-13. PMID 11172137  0.32
2001 Hauswirth WW, LaVail MM, Flannery JG, Lewin AS. Viral-vectored ribozymes as therapy for autosomal dominant retinal disease Clinical Neuroscience Research. 1: 118-126.  0.32
2000 Hauswirth WW, Lewin AS. Ribozyme uses in retinal gene therapy Progress in Retinal and Eye Research. 19: 689-710. PMID 11029552 DOI: 10.1016/S1350-9462(00)00007-0  0.32
2000 LaVail MM, Yasumura D, Matthes MT, Drenser KA, Flannery JG, Lewin AS, Hauswirth WW. Ribozyme rescue of photoreceptor cells in P23H transgenic rats: long-term survival and late-stage therapy. Proceedings of the National Academy of Sciences of the United States of America. 97: 11488-93. PMID 11005848 DOI: 10.1073/pnas.210319397  0.32
2000 Hauswirth WW, LaVail MM, Flannery JG, Lewin AS. Ribozyme gene therapy for autosomal dominant retinal disease. Clinical Chemistry and Laboratory Medicine : Cclm / Fescc. 38: 147-53. PMID 10834402 DOI: 10.1515/CCLM.2000.022  0.32
2000 Shaw LC, Whalen PO, Drenser KA, Yan W, Hauswirth WW, Lewin AS. Ribozymes in treatment of inherited retinal disease. Methods in Enzymology. 316: 761-76. PMID 10800713  0.32
2000 Hauswirth WW, Lewin AS, Zolotukhin S, Muzyczka N. Production and purification of recombinant adeno-associated virus. Methods in Enzymology. 316: 743-61. PMID 10800712  0.32
1999 Tirupati HK, Shaw LC, Lewin AS. An RNA binding motif in the Cbp2 protein required for protein-stimulated RNA catalysis Journal of Biological Chemistry. 274: 30393-30401. PMID 10521416 DOI: 10.1074/jbc.274.43.30393  0.32
1998 Lewin AS, Drenser KA, Hauswirth WW, Nishikawa S, Yasumura D, Flannery JG, LaVail MM. Ribozyme rescue of photoreceptor cells in a transgenic rat model of autosomal dominant retinitis pigmentosa. Nature Medicine. 4: 967-71. PMID 9701253 DOI: 10.1038/nm0898-967  0.32
1998 Drenser KA, Timmers AM, Hauswirth WW, Lewin AS. Ribozyme-targeted destruction of RNA associated with autosomal-dominant retinitis pigmentosa Investigative Ophthalmology and Visual Science. 39: 681-689. PMID 9538873  0.32
1997 Nguyen MH, Clancy CJ, Yu YC, Lewin AS. Potentiation of antifungal activity of amphotericin B by azithromycin against Aspergillus species. European Journal of Clinical Microbiology & Infectious Diseases : Official Publication of the European Society of Clinical Microbiology. 16: 846-8. PMID 9447909  0.32
1997 Shaw LC, Lewin AS. The Cbp2 protein stimulates the splicing of the ω intron of yeast mitochondria Nucleic Acids Research. 25: 1597-1604. PMID 9092668 DOI: 10.1093/nar/25.8.1597  0.32
1997 Drenser KD, Hauswirth WW, Lewin AS. Riro/ymf mediated degradation of the p23h and s334ter mutant mRNAs associated with adrp Investigative Ophthalmology and Visual Science. 38.  0.32
1997 Clancy CJ, Yu YC, Lewin AS, Nguyen MH. Potentiation of antifungal activity of amphotericin B by azithromycin: Demonstration of in vitro synergy against Aspergillus and Fusarium Clinical Infectious Diseases. 25: 488.  0.32
1996 Shaw LC, Thomas J, Lewin AS. The Cbp2 protein suppresses splice site mutations in a group I intron Nucleic Acids Research. 24: 3415-3423. PMID 8811097  0.32
1996 Drenser KA, Lewin AS, Hauswirth WW. Ribozyme mediated destruction of an mRNA causing retinitis pigmentosis Investigative Ophthalmology and Visual Science. 37.  0.32
1995 Lewin AS, Thomas J, Tirupati HK. Cotranscriptional splicing of a group I intron is facilitated by the Cbp2 protein Molecular and Cellular Biology. 15: 6971-6978. PMID 8524264  0.32
1995 Shaw LC, Lewin AS. Protein-induced folding of a group I intron in cytochrome b pre-mRNA Journal of Biological Chemistry. 270: 21552-21562. PMID 7665568 DOI: 10.1074/jbc.270.37.21552  0.32
1993 Tuttle DL, Lewin AS, Dunn WA. Selective autophagy of peroxisomes in methylotrophic yeasts European Journal of Cell Biology. 60: 283-290. PMID 8330626  0.32
1993 Fernandez A, Lewin AS, Rabitz H. Structure-induced strain determining the internal cyclization site in the yeast cobI5 autocatalytic intron: Theory and experimental tests Journal of Theoretical Biology. 164: 121-133. PMID 8264241 DOI: 10.1006/jtbi.1993.1143  0.32
1992 Wang TW, Lewin AS, Small GM. A negative regulating element controlling transcription of the gene encoding acyl-CoA oxidase in Saccharomyces cerevisiae. Nucleic Acids Research. 20: 3495-500. PMID 1630920 DOI: 10.1093/nar/20.13.3495  0.32
1992 Singh KK, Small GM, Lewin AS. Alternative topogenic signals in peroxisomal citrate synthase of Saccharomyces cerevisiae Molecular and Cellular Biology. 12: 5593-5599. PMID 1448089  0.32
1992 Ritchings BW, Lewin AS. Mutational evidence for competition between the P1 and the P10 helices of a mitochondrial group I intron Nucleic Acids Research. 20: 2349-2353. PMID 1375737 DOI: 10.1093/nar/20.9.2349  0.32
1991 Partono S, Lewin AS. The rate and specificity of a group I ribozyme are inversely affected by choice of monovalent salt Nucleic Acids Research. 19: 605-609. PMID 2011532 DOI: 10.1093/nar/19.3.605  0.32
1990 Partono S, Lewin AS. Splicing of COB intron 5 requires pairing between the internal guide sequence and both flanking exons Proceedings of the National Academy of Sciences of the United States of America. 87: 8192-8196. PMID 2236031  0.32
1990 Small GM, Lewin AS. Protein targeting to peroxisomes Biochemical Society Transactions. 18: 85-87. PMID 2185098  0.32
1990 Lewin AS, Hines V, Small GM. Citrate synthase encoded by the CIT2 gene of Saccharomyces cerevisiae is peroxisomal Molecular and Cellular Biology. 10: 1399-1405. PMID 2181273  0.32
1988 Partono S, Lewin AS. Autocatalytic activities of intron 5 of the cob gene of yeast mitochondria Molecular and Cellular Biology. 8: 2562-2571. PMID 3043183  0.32
1987 Sahota A, Ranjekar PK, Alfonzo J, Lewin AS, Taylor MW. Mutants of Saccharomyces cerevisiae deficient in adenine phosphoribosyltransferase Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis. 180: 81-87. PMID 3306356 DOI: 10.1016/0027-5107(87)90069-8  0.32
1987 Hefta LJF, Lewin AS, Daignan-Fornier B, Bolotin-Fukuhara M. Nuclear and mitochondrial revertants of a mitochondrial mutant with a defect in the ATP synthetase complex Mgg Molecular &Amp; General Genetics. 207: 106-113. PMID 2885722 DOI: 10.1007/BF00331497  0.32
1986 Rickey TM, Lewin AS. Extramitochondrial citrate synthase activity in baker's yeast Molecular and Cellular Biology. 6: 488-493. PMID 3023850  0.32
1986 Burns DJ, Lewin AS. The rate of import and assembly of F1-ATPase in Saccharomyces cerevisiae Journal of Biological Chemistry. 261: 12066-12073. PMID 2875070  0.32
1984 Jenkins WT, Marshall MM, Lewin AS. Hypothesis--a chemical mechanism for the biosynthesis of ATP involving ion-exchange reactions. Archives of Biochemistry and Biophysics. 232: 496-504. PMID 6235776 DOI: 10.1016/0003-9861(84)90566-6  0.32
1984 Hoosein MA, Lewin AS. Derepression of citrate synthase in Saccharomyces cerevisiae May occur at the level of transcription Molecular and Cellular Biology. 4: 247-253. PMID 6199662  0.32
1984 Jenkins WT, Marshall MM, Lewin AS. Hypothesis. A chemical mechanism for the biosynthesis of ATP involving ion exchange reactions Federation Proceedings. 43.  0.32
1983 Hampsey DM, Lewin AS, Kohlhaw GB. Submitochondrial localization, cell-free synthesis, and mitochondrial import of 2-isopropylmalate synthase of yeast Proceedings of the National Academy of Sciences of the United States of America. 80: 1270-1274. PMID 6338500  0.32
1983 Lewin AS, Norman DK. Assembly of F1-ATPase in isolated mitochondria Journal of Biological Chemistry. 258: 6750-6755. PMID 6222049  0.32
Low-probability matches
2018 Cideciyan AV, Sudharsan R, Dufour VL, Massengill MT, Iwabe S, Swider M, Lisi B, Sumaroka A, Marinho LF, Appelbaum T, Rossmiller B, Hauswirth WW, Jacobson SG, Lewin AS, Aguirre GD, et al. Mutation-independent rhodopsin gene therapy by knockdown and replacement with a single AAV vector. Proceedings of the National Academy of Sciences of the United States of America. PMID 30127005 DOI: 10.1073/pnas.1805055115  0.28
2013 Ruan Q, Xi L, Boye SL, Han S, Chen ZJ, Hauswirth WW, Lewin AS, Boulton ME, Law BK, Jiang WG, Jiang H, Cai J. Development of an anti-angiogenic therapeutic model combining scAAV2-delivered siRNAs and noninvasive photoacoustic imaging of tumor vasculature development. Cancer Letters. 332: 120-9. PMID 23196055 DOI: 10.1016/j.canlet.2012.11.016  0.28
2010 Gorbatyuk OS, Li S, Nash K, Gorbatyuk M, Lewin AS, Sullivan LF, Mandel RJ, Chen W, Meyers C, Manfredsson FP, Muzyczka N. In Vivo RNAi-Mediated α-Synuclein Silencing Induces Nigrostriatal Degeneration. Molecular Therapy : the Journal of the American Society of Gene Therapy. 18: 1450-1457. PMID 28178505 DOI: 10.1038/mt.2010.115  0.28
2008 Gorbatyuk MS, Hauswirth WW, Lewin AS. Gene therapy for mouse models of ADRP. Advances in Experimental Medicine and Biology. 613: 107-12. PMID 18188934 DOI: 10.1007/978-0-387-74904-4_11  0.28
2002 Fritz JJ, White DA, Lewin AS, Hauswirth WW. Designing and characterizing hammerhead ribozymes for use in AAV vector-mediated retinal gene therapies. Methods in Enzymology. 346: 358-77. PMID 11883079  0.28
2019 Gorbatyuk OS, Warrington KH, Gorbatyuk MS, Zolotukhin I, Lewin AS, Muzyczka N. Biodistribution of Adeno-Associated Virus Type 2 with Mutations in the Capsid that Contribute to Heparan Sulfate Proteoglycan Binding. Virus Research. 197771. PMID 31577935 DOI: 10.1016/j.virusres.2019.197771  0.04
2017 Song C, Mitter SK, Qi X, Beli E, Rao HV, Ding J, Ip CS, Gu H, Akin D, Dunn WA, Bowes Rickman C, Lewin AS, Grant MB, Boulton ME. Oxidative stress-mediated NFκB phosphorylation upregulates p62/SQSTM1 and promotes retinal pigmented epithelial cell survival through increased autophagy. Plos One. 12: e0171940. PMID 28222108 DOI: 10.1371/journal.pone.0171940  0.04
2017 Qi X, Pay SL, Yan Y, Thomas J, Lewin AS, Chang LJ, Grant MB, Boulton ME. Systemic Injection of RPE65-Programmed Bone Marrow-Derived Cells Prevents Progression of Chronic Retinal Degeneration. Molecular Therapy : the Journal of the American Society of Gene Therapy. PMID 28202390 DOI: 10.1016/j.ymthe.2017.01.015  0.04
2003 Cheng S, Clancy CJ, Checkley MA, Handfield M, Hillman JD, Progulske-Fox A, Lewin AS, Fidel PL, Nguyen MH. Identification of Candida albicans genes induced during thrush offers insight into pathogenesis. Molecular Microbiology. 48: 1275-88. PMID 12787355  0.04
2019 Young BM, Jones K, Massengill MT, Walsh E, Li H, Lewin AS, Ildefonso CJ. Expression of a CARD Slows the Retinal Degeneration of a Geographic Atrophy Mouse Model. Molecular Therapy. Methods & Clinical Development. 14: 113-125. PMID 31334304 DOI: 10.1016/j.omtm.2019.06.001  0.01
2019 Chang LJ, Lewin AS. Preface. Current Gene Therapy. 19: 1. PMID 31190638 DOI: 10.2174/156652321901190502112219  0.01
2019 Chang LJ, Lewin AS. Preface Current Gene Therapy. PMID 31071761 DOI: 10.2174/156652321901190502112219  0.01
2019 Brown EE, DeWeerd AJ, Ildefonso CJ, Lewin AS, Ash JD. Mitochondrial oxidative stress in the retinal pigment epithelium (RPE) led to metabolic dysfunction in both the RPE and retinal photoreceptors. Redox Biology. 24: 101201. PMID 31039480 DOI: 10.1016/j.redox.2019.101201  0.01
2019 Garg RR, Jackson CB, Rahman MM, Khan AR, Lewin AS, McFadden G. Myxoma virus M013 protein antagonizes NF-κB and inflammasome pathways via distinct structural motifs. The Journal of Biological Chemistry. PMID 30940649 DOI: 10.1074/jbc.RA118.006040  0.01
2019 Massengill MT, Young BM, Lewin AS, Ildefonso CJ. Co-Delivery of a Short-Hairpin RNA and a shRNA-Resistant Replacement Gene with Adeno-Associated Virus: An Allele-Independent Strategy for Autosomal-Dominant Retinal Disorders. Methods in Molecular Biology (Clifton, N.J.). 1937: 235-258. PMID 30706401 DOI: 10.1007/978-1-4939-9065-8_15  0.01
2018 Massengill MT, Young B, Patel D, Jafri F, Sabogal E, Ash N, Li H, Ildefonso CJ, Lewin AS. Clinically Relevant Outcome Measures for the I307N Rhodopsin Mouse: A Model of Inducible Autosomal Dominant Retinitis Pigmentosa. Investigative Ophthalmology & Visual Science. 59: 5417-5430. PMID 30452595 DOI: 10.1167/iovs.18-25345  0.01
2018 Biswal MR, Justis BD, Han P, Li H, Gierhart D, Dorey CK, Lewin AS. Daily zeaxanthin supplementation prevents atrophy of the retinal pigment epithelium (RPE) in a mouse model of mitochondrial oxidative stress. Plos One. 13: e0203816. PMID 30265681 DOI: 10.1371/journal.pone.0203816  0.01
2018 Ildefonso CJ, Lewin AS. Adeno-Associated Virus Delivery of Viral Serpins for Ocular Diseases: Design and Validation. Methods in Molecular Biology (Clifton, N.J.). 1826: 237-254. PMID 30194605 DOI: 10.1007/978-1-4939-8645-3_16  0.01
2018 Biswal MR, Prentice HM, Smith GW, Zhu P, Tong Y, Dorey CK, Lewin AS, Blanks JC. Cell-specific gene therapy driven by an optimized hypoxia-regulated vector reduces choroidal neovascularization. Journal of Molecular Medicine (Berlin, Germany). PMID 30105447 DOI: 10.1007/s00109-018-1683-0  0.01
2018 Ahmed CM, Massengill MT, Brown EE, Ildefonso CJ, Johnson HM, Lewin AS. A cell penetrating peptide from SOCS-1 prevents ocular damage in experimental autoimmune uveitis. Experimental Eye Research. 177: 12-22. PMID 30048621 DOI: 10.1016/j.exer.2018.07.020  0.01
2018 Watson ZL, Washington SD, Phelan DM, Lewin AS, Tuli SS, Schultz GS, Neumann DM, Bloom DC. Knock-down of the HSV-1 Latency-Associated Transcript Reduces Reactivation from Latency. Journal of Virology. PMID 29875240 DOI: 10.1128/JVI.00812-18  0.01
2018 Chang LJ, Lewin AS. Preface: Translational Gene Therapy Coming of Age! Current Gene Therapy. 18: 1. PMID 29769000 DOI: 10.2174/156652321801180503163908  0.01
2018 Massengill MT, Ahmed CM, Lewin AS, Ildefonso CJ. Neuroinflammation in Retinitis Pigmentosa, Diabetic Retinopathy, and Age-Related Macular Degeneration: A Minireview. Advances in Experimental Medicine and Biology. 1074: 185-191. PMID 29721943 DOI: 10.1007/978-3-319-75402-4_23  0.01
2018 Brown EE, Lewin AS, Ash JD. Mitochondria: Potential Targets for Protection in Age-Related Macular Degeneration. Advances in Experimental Medicine and Biology. 1074: 11-17. PMID 29721922 DOI: 10.1007/978-3-319-75402-4_2  0.01
2018 Schnabolk G, Parsons N, Obert E, Annamalai B, Nasarre C, Tomlinson S, Lewin AS, Rohrer B. Delivery of CR2-fH Using AAV Vector Therapy as Treatment Strategy in the Mouse Model of Choroidal Neovascularization. Molecular Therapy. Methods & Clinical Development. 9: 1-11. PMID 29234687 DOI: 10.1016/j.omtm.2017.11.003  0.01
2017 Biswal MR, Han P, Zhu P, Wang Z, Li H, Ildefonso CJ, Lewin AS. Timing of Antioxidant Gene Therapy: Implications for Treating Dry AMD. Investigative Ophthalmology & Visual Science. 58: 1237-1245. PMID 28241311 DOI: 10.1167/iovs.16-21272  0.01
2016 Ahmed CM, Biswal MR, Li H, Han P, Ildefonso CJ, Lewin AS. Repurposing an orally available drug for the treatment of geographic atrophy. Molecular Vision. 22: 294-310. PMID 27110092  0.01
2016 Eide KB, Stockinger LW, Lewin AS, Tøndervik A, Eijsink VGH, Sørlie M. The role of active site aromatic residues in substrate degradation by the human chitotriosidase Biochimica Et Biophysica Acta - Proteins and Proteomics. 1864: 242-247. PMID 26621384 DOI: 10.1016/j.bbapap.2015.11.007  0.01
2015 Biswal MR, Ahmed CM, Ildefonso CJ, Han P, Li H, Jivanji H, Mao H, Lewin AS. Systemic treatment with a 5HT1a agonist induces anti-oxidant protection and preserves the retina from mitochondrial oxidative stress. Experimental Eye Research. 140: 94-105. PMID 26315784 DOI: 10.1016/j.exer.2015.07.022  0.01
2014 Lewin AS, Rossmiller B, Mao H. Gene augmentation for adRP mutations in RHO. Cold Spring Harbor Perspectives in Medicine. 4: a017400. PMID 25037104 DOI: 10.1101/cshperspect.a017400  0.01
2009 Lewin AS. Geographic atrophy in age-related macular degeneration and TLR3. The New England Journal of Medicine. 360: 2251; author reply 2. PMID 19458376 DOI: 10.1056/NEJMc082233  0.01
2009 Lewin AS. Geographic atrophy in age-related macular degeneration and TLR3 New England Journal of Medicine. 360: 2251. DOI: 10.1056/NEJMc082233  0.01
1980 Lewin AS, Gregor I, Mason TL, Nelson N, Schatz G. Cytoplasmically made subunits of yeast mitochondrial F 1-ATPase and cytochrome c oxidase are synthesized as individual precursors, not as polyproteins Proceedings of the National Academy of Sciences of the United States of America. 77: 3998-4002. PMID 6254007 DOI: 10.1073/pnas.77.7.3998  0.01
1979 Lewin AS, Morimoto R, Rabinowitz M. Stable heterogeneity of mitochondrial DNA in grande and petite strains of S. cerevisiae Plasmid. 2: 474-484. PMID 384424 DOI: 10.1016/0147-619X(79)90031-3  0.01
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