| Year |
Citation |
Score |
| 2022 |
Jin Q, Gutierrez Diaz B, Pieters T, Zhou Y, Narang S, Fijalkwoski I, Borin C, Van Laere J, Payton M, Cho BK, Han C, Sun L, Serafin V, Yacu G, Von Loocke W, ... ... Crispino JD, et al. Oncogenic deubiquitination controls tyrosine kinase signaling and therapy response in acute lymphoblastic leukemia. Science Advances. 8: eabq8437. PMID 36490346 DOI: 10.1126/sciadv.abq8437 |
0.321 |
|
| 2022 |
Zhao X, Bartholdy B, Yamamoto Y, Evans EK, Alberich-Jordà M, Staber PB, Benoukraf T, Zhang P, Zhang J, Trinh BQ, Crispino JD, Hoang T, Bassal MA, Tenen DG. PU.1-c-Jun interaction is crucial for PU.1 function in myeloid development. Communications Biology. 5: 961. PMID 36104445 DOI: 10.1038/s42003-022-03888-7 |
0.316 |
|
| 2022 |
Rammohan M, Harris E, Bhansali RS, Zhao E, Li LS, Crispino JD. The chromosome 21 kinase DYRK1A: emerging roles in cancer biology and potential as a therapeutic target. Oncogene. PMID 35220406 DOI: 10.1038/s41388-022-02245-6 |
0.756 |
|
| 2021 |
Bhansali RS, Rammohan M, Lee P, Laurent AP, Wen Q, Suraneni P, Yip BH, Tsai YC, Jenni S, Bornhauser B, Siret A, Fruit C, Pacheco-Benichou A, Harris E, Besson T, ... ... Crispino JD, et al. DYRK1A regulates B cell acute lymphoblastic leukemia through phosphorylation of FOXO1 and STAT3. The Journal of Clinical Investigation. 131. PMID 33393494 DOI: 10.1172/JCI135937 |
0.774 |
|
| 2020 |
Schieber M, Marinaccio C, Bolanos LC, Haffey WD, Greis KD, Starczynowski DT, Crispino JD. FBXO11 is a candidate tumor suppressor in the leukemic transformation of myelodysplastic syndrome. Blood Cancer Journal. 10: 98. PMID 33024076 DOI: 10.1038/s41408-020-00362-7 |
0.328 |
|
| 2020 |
Fang C, Rao S, Crispino JD, Ntziachristos P. Determinants and role of chromatin organization in acute leukemia. Leukemia. PMID 32690881 DOI: 10.1038/S41375-020-0981-Z |
0.417 |
|
| 2020 |
Laurent AP, Siret A, Ignacimouttou C, Panchal K, Diop M, Jenni S, Tsai YC, Roos-Weil D, Aid Z, Prade N, Lagarde S, Plassard D, Pierron G, Daudigeos E, Lecluse Y, ... ... Crispino JD, et al. Constitutive activation of RAS/MAPK pathway cooperates with trisomy 21 and is therapeutically exploitable in Down syndrome B-cell leukemia. Clinical Cancer Research : An Official Journal of the American Association For Cancer Research. PMID 32220889 DOI: 10.1158/1078-0432.Ccr-19-3519 |
0.334 |
|
| 2019 |
Fruit C, Couly F, Bhansali R, Rammohan M, Lindberg MF, Crispino JD, Meijer L, Besson T. Biological Characterization of 8-Cyclopropyl-2-(pyridin-3-yl)thiazolo[5,4-]quinazolin-9(8)-one, a Promising Inhibitor of DYRK1A. Pharmaceuticals (Basel, Switzerland). 12. PMID 31861110 DOI: 10.3390/Ph12040185 |
0.753 |
|
| 2019 |
Strouboulis J, Crispino JD. Preface to IUBMB life special issue on GATA transcription factors in development, differentiation, and disease. Iubmb Life. PMID 31778018 DOI: 10.1002/Iub.2205 |
0.307 |
|
| 2019 |
Ling T, Crispino JD. GATA1 mutations in red cell disorders. Iubmb Life. PMID 31652397 DOI: 10.1002/Iub.2177 |
0.431 |
|
| 2019 |
McNulty M, Crispino JD. Acute Megakaryocytic Leukemia. Cold Spring Harbor Perspectives in Medicine. PMID 31548219 DOI: 10.1101/Cshperspect.A034884 |
0.413 |
|
| 2019 |
Schieber M, Crispino JD, Stein B. Myelofibrosis in 2019: moving beyond JAK2 inhibition. Blood Cancer Journal. 9: 74. PMID 31511492 DOI: 10.1038/S41408-019-0236-2 |
0.354 |
|
| 2019 |
Ling T, Birger Y, Stankiewicz MJ, Ben-Haim N, Kalisky T, Rein A, Kugler E, Chen W, Fu C, Zhang K, Patel H, Sikora JW, Goo YA, Kelleher N, Zou L, ... ... Crispino JD, et al. Chromatin occupancy and epigenetic analysis reveal new insights into the function of GATA1 N-terminus in erythropoiesis. Blood. PMID 31409672 DOI: 10.1182/Blood.2019001234 |
0.431 |
|
| 2019 |
Labuhn M, Perkins K, Matzk S, Varghese L, Garnett C, Papaemmanuil E, Metzner M, Kennedy A, Amstislavskiy V, Risch T, Bhayadia R, Samulowski D, Hernandez DC, Stoilova B, Iotchkova V, ... ... Crispino JD, et al. Mechanisms of Progression of Myeloid Preleukemia to Transformed Myeloid Leukemia in Children with Down Syndrome. Cancer Cell. PMID 31303423 DOI: 10.1016/J.Ccell.2019.06.007 |
0.384 |
|
| 2019 |
Woods B, Chen W, Chiu S, Marinaccio C, Fu C, Gu L, Bulic M, Yang Q, Zouak A, Jia S, Suraneni PK, Xu K, Levine RL, Crispino JD, Wen QJ. Activation of JAK/STAT signaling in megakaryocytes sustains myeloproliferation . Clinical Cancer Research : An Official Journal of the American Association For Cancer Research. PMID 31217200 DOI: 10.1158/1078-0432.Ccr-18-4089 |
0.358 |
|
| 2019 |
Gangat N, Marinaccio C, Swords R, Watts JM, Gurbuxani S, Rademaker A, Fought AJ, Frankfurt O, Altman JK, Wen QJ, Farnoud N, Famulare CA, Patel A, Tapia R, Vallapureddy RR, ... ... Crispino JD, et al. Aurora kinase A inhibition provides clinical benefit, normalizes megakaryocytes and reduces bone marrow fibrosis in patients with myelofibrosis. Clinical Cancer Research : An Official Journal of the American Association For Cancer Research. PMID 31061068 DOI: 10.1158/1078-0432.Ccr-19-1005 |
0.333 |
|
| 2019 |
Lally J, Boasman K, Brown L, Martinelli V, Cappuccio I, Sovani V, Marinaccio C, Crispino JD, Graham C, Rinaldi C. GATA-1 a potential novel biomarker for the differentiation of essential thrombocythaemia and myelofibrosis. Journal of Thrombosis and Haemostasis : Jth. PMID 30889303 DOI: 10.1111/Jth.14433 |
0.438 |
|
| 2019 |
Zhao Z, Wang L, Volk AG, Birch NW, Stoltz KL, Bartom ET, Marshall SA, Rendleman EJ, Nestler CM, Shilati J, Schiltz GE, Crispino JD, Shilatifard A. Regulation of MLL/COMPASS stability through its proteolytic cleavage by taspase1 as a possible approach for clinical therapy of leukemia. Genes & Development. 33: 61-74. PMID 30573454 DOI: 10.1101/Gad.319830.118 |
0.41 |
|
| 2019 |
Schieber M, Crispino JD. FBXO11 Is a Candidate Tumor Suppressor in the Transformation of MDS to Secondary AML Blood. 134: 4217-4217. DOI: 10.1182/Blood-2019-124007 |
0.436 |
|
| 2019 |
Hurtz C, Wertheim G, Bhansali RS, Lehman A, Jeschke G, Crispino JD, Besson T, Tasian SK, Carroll M. DYRK1A Is Regulated By Oncogenic KMT2A and Required for Survival of KMT2A-Rearranged Acute Lymphoblastic Leukemia Blood. 134: 2742-2742. DOI: 10.1182/Blood-2019-123475 |
0.452 |
|
| 2018 |
Suraneni PK, Corey SJ, Hession MJ, Ishaq R, Awomolo A, Hasan S, Shah C, Liu H, Wickrema A, Debili N, Crispino JD, Eklund EA, Chen Y. Dynamins 2 and 3 control the migration of human megakaryocytes by regulating CXCR4 surface expression and ITGB1 activity. Blood Advances. 2: 3540-3552. PMID 30538113 DOI: 10.1182/Bloodadvances.2018021923 |
0.397 |
|
| 2018 |
Fu C, Shi X, Gong Y, Wan Y, Sun Z, Shi H, Wang Z, Marinaccio C, Crispino JD, Xu K. Constitutively Photomorphogenic 1 Reduces the Sensitivity of Chronic Lymphocytic Leukemia Cells to Fludarabine Through Promotion of Ubiquitin-Mediated P53 Degradation. Cellular Physiology and Biochemistry : International Journal of Experimental Cellular Physiology, Biochemistry, and Pharmacology. 50: 2314-2328. PMID 30423551 DOI: 10.1159/000495092 |
0.418 |
|
| 2018 |
Volk A, Liang K, Suraneni P, Li X, Zhao J, Bulic M, Marshall S, Pulakanti K, Malinge S, Taub J, Ge Y, Rao S, Bartom E, Shilatifard A, Crispino JD. A CHAF1B-Dependent Molecular Switch in Hematopoiesis and Leukemia Pathogenesis. Cancer Cell. 34: 707-723.e7. PMID 30423293 DOI: 10.1016/J.Ccell.2018.10.004 |
0.37 |
|
| 2018 |
Payton M, Cheung HK, Ninniri MSS, Marinaccio C, Wayne WC, Hanestad K, Crispino JD, Juan G, Coxon A. Dual targeting of aurora kinases with AMG 900 exhibits potent preclinical activity against acute myeloid leukemia with distinct post-mitotic outcomes. Molecular Cancer Therapeutics. PMID 30266802 DOI: 10.1158/1535-7163.Mct-18-0186 |
0.442 |
|
| 2018 |
Jin Q, Martinez CA, Arcipowski KM, Zhu Y, Gutiérrez-Díaz BT, Wang KK, Johnson MR, Volk A, Wang F, Wu J, Grove C, Wang H, Sokirniy I, Thomas PM, Goo YA, ... ... Crispino JD, et al. USP7 cooperates with NOTCH1 to drive the oncogenic transcriptional program in T cell leukemia. Clinical Cancer Research : An Official Journal of the American Association For Cancer Research. PMID 30224337 DOI: 10.1158/1078-0432.Ccr-18-1740 |
0.335 |
|
| 2018 |
Swaroop A, Oyer JA, Will CM, Huang X, Yu W, Troche C, Bulic M, Durham BH, Wen QJ, Crispino JD, MacKerell AD, Bennett RL, Kelleher NL, Licht JD. An activating mutation of the NSD2 histone methyltransferase drives oncogenic reprogramming in acute lymphocytic leukemia. Oncogene. PMID 30171259 DOI: 10.1038/S41388-018-0474-Y |
0.429 |
|
| 2018 |
Khan I, Halasi M, Patel A, Schultz R, Kalakota N, Chen YH, Aardsma N, Liu L, Crispino JD, Mahmud N, Frankfurt O, Gartel AL. FOXM1 contributes to treatment failure in acute myeloid leukemia. Jci Insight. 3. PMID 30089730 DOI: 10.1172/Jci.Insight.121583 |
0.418 |
|
| 2018 |
Melo-Cardenas J, Xu Y, Wei J, Tan C, Kong S, Gao B, Montauti E, Kirsammer G, Licht JD, Yu J, Ji P, Crispino JD, Fang D. USP22 deficiency leads to myeloid leukemia upon oncogenic Kras activation through a PU.1 dependent mechanism. Blood. PMID 29844011 DOI: 10.1182/Blood-2017-10-811760 |
0.817 |
|
| 2018 |
Crispino JD. JAK2 and JMJD1C activate NFE2 in MPNs. Blood. 131: 1998-1999. PMID 29724716 DOI: 10.1182/Blood-2018-03-839779 |
0.315 |
|
| 2018 |
Gnanapragasam MN, Crispino JD, Ali AM, Weinberg R, Hoffman R, Raza A, Bieker JJ. Survey and evaluation of mutations in the human KLF1 transcription unit. Scientific Reports. 8: 6587. PMID 29700354 DOI: 10.1038/S41598-018-24962-3 |
0.403 |
|
| 2018 |
Yang X, Lu B, Sun X, Han C, Fu C, Xu K, Wang M, Li D, Chen Z, Opal P, Wen Q, Crispino JD, Wang QF, Huang Z. ANP32A regulates histone H3 acetylation and promotes leukemogenesis. Leukemia. PMID 29467488 DOI: 10.1038/S41375-018-0010-7 |
0.374 |
|
| 2018 |
Ling T, Crispino JD, Zingariello M, Martelli F, Migliaccio AR. GATA1 insufficiencies in primary myelofibrosis and other hematopoietic disorders: consequences for therapy. Expert Review of Hematology. PMID 29400094 DOI: 10.1080/17474086.2018.1436965 |
0.457 |
|
| 2018 |
Bhansali RS, Rammohan M, Lee JHP, Malinge S, Tsai Y, Hijiya N, Bornhauser B, Bourquin J, Fruit C, Besson T, Crispino JD. The Chromosome 21 Kinase DYRK1A and Its Substrate FOXO1 Constitute a Novel Therapeutic Pathway in B-ALL Blood. 132: 548-548. DOI: 10.1182/Blood-2018-99-119854 |
0.437 |
|
| 2018 |
Suraneni PK, Corey SJ, Hession M, Ishaq R, Awomolo A, Hasan S, Debili N, Crispino JD, Eklund EA, Chen Y. Dynamins 2 and 3 Are Required for Human Megakaryocytes Directional Migration Blood. 132: 2429-2429. DOI: 10.1182/Blood-2018-99-118782 |
0.413 |
|
| 2018 |
Labuhn M, Perkins K, Papaemmanuil E, Garnett C, Matzk S, Amstislavskiy V, Metzner M, Kennedy A, Scheer C, Yoshida K, Schwarzer A, Crispino JD, Taub JW, Weiss MJ, Ito E, et al. Modelling the Progression of a Preleukemic Stage to Overt Leukemia in Children with Down Syndrome Blood. 132: 543-543. DOI: 10.1182/Blood-2018-99-116661 |
0.466 |
|
| 2018 |
Rammohan M, Bhansali RS, Tsai Y, Dong A, Malinge S, Bourquin J, Crispino JD. STAT3 Is Activated By DYRK1A and Is a Potential Therapeutic Target in B-ALL Blood. 132: 3898-3898. DOI: 10.1182/Blood-2018-99-115429 |
0.443 |
|
| 2018 |
Ling T, Birger Y, Stankiewicz M, Ben-Haim N, Kanter I, Kalisky T, Rein Gil A, Kelleher NL, Zou L, Izraeli S, Crispino JD. Global Chromatin Occupancy and Epigenetic Signature Analysis Reveal New Insights into the Function of GATA1 N-Terminus in Erythropoiesis Blood. 132: 533-533. DOI: 10.1182/Blood-2018-99-115338 |
0.5 |
|
| 2017 |
Sun X, Lu B, Han C, Qiu W, Jin Q, Li D, Li Q, Yang Q, Wen Q, Opal P, Kini AR, Crispino JD, Huang Z. ANP32A dysregulation contributes to abnormal megakaryopoiesis in acute megakaryoblastic leukemia. Blood Cancer Journal. 7: 661. PMID 29269781 DOI: 10.1038/S41408-017-0031-X |
0.312 |
|
| 2017 |
Nitulescu II, Meyer SC, Wen QJ, Crispino JD, Lemieux ME, Levine RL, Pelish HE, Shair MD. Mediator Kinase Phosphorylation of STAT1 S727 Promotes Growth of Neoplasms With JAK-STAT Activation. Ebiomedicine. 26: 112-125. PMID 29239838 DOI: 10.1016/J.Ebiom.2017.11.013 |
0.393 |
|
| 2017 |
Zhao B, Mei Y, Cao L, Zhang J, Sumagin R, Yang J, Gao J, Schipma MJ, Wang Y, Thorsheim C, Zhao L, Stalker T, Stein B, Wen QJ, Crispino JD, et al. Loss of pleckstrin-2 reverts lethality and vascular occlusions in JAK2V617F-positive myeloproliferative neoplasms. The Journal of Clinical Investigation. PMID 29202466 DOI: 10.1172/Jci94518 |
0.408 |
|
| 2017 |
Fisher JB, McNulty M, Burke MJ, Crispino JD, Rao S. Cohesin Mutations in Myeloid Malignancies. Trends in Cancer. 3: 282-293. PMID 28626802 DOI: 10.1016/J.Trecan.2017.02.006 |
0.406 |
|
| 2017 |
Zingariello M, Sancillo L, Martelli F, Ciaffoni F, Marra M, Varricchio L, Rana RA, Zhao C, Crispino JD, Migliaccio AR. The thrombopoietin/MPL axis is activated in the Gata1(low) mouse model of myelofibrosis and is associated with a defective RPS14 signature. Blood Cancer Journal. 7: e572. PMID 28622305 DOI: 10.1038/Bcj.2017.51 |
0.397 |
|
| 2017 |
Ansó E, Weinberg SE, Diebold LP, Thompson BJ, Malinge S, Schumacker PT, Liu X, Zhang Y, Shao Z, Steadman M, Marsh KM, Xu J, Crispino JD, Chandel NS. The mitochondrial respiratory chain is essential for haematopoietic stem cell function. Nature Cell Biology. PMID 28504706 DOI: 10.1038/Ncb3529 |
0.352 |
|
| 2017 |
Thirant C, Ignacimouttou C, Lopez CK, Diop M, Le Mouël L, Thiollier C, Siret A, Dessen P, Aid Z, Rivière J, Rameau P, Lefebvre C, Khaled M, Leverger G, Ballerini P, ... ... Crispino JD, et al. ETO2-GLIS2 Hijacks Transcriptional Complexes to Drive Cellular Identity and Self-Renewal in Pediatric Acute Megakaryoblastic Leukemia. Cancer Cell. 31: 452-465. PMID 28292442 DOI: 10.1016/J.Ccell.2017.02.006 |
0.413 |
|
| 2017 |
Mosoyan G, Kraus T, Ye F, Eng K, Crispino JD, Hoffman R, Iancu-Rubin C. Imetelstat, a telomerase inhibitor, differentially affects normal and malignant megakaryopoiesis. Leukemia. PMID 28270692 DOI: 10.1038/Leu.2017.78 |
0.359 |
|
| 2017 |
Gilles L, Arslan AD, Marinaccio C, Wen QJ, Arya P, McNulty M, Yang Q, Zhao JC, Konstantinoff K, Lasho T, Pardanani A, Stein B, Plo I, Sundaravel S, Wickrema A, ... ... Crispino JD, et al. Downregulation of GATA1 drives impaired hematopoiesis in primary myelofibrosis. The Journal of Clinical Investigation. PMID 28240607 DOI: 10.1172/Jci82905 |
0.463 |
|
| 2017 |
Crispino JD, Horwitz MS. GATA factor mutations in hematologic disease. Blood. PMID 28179280 DOI: 10.1182/Blood-2016-09-687889 |
0.395 |
|
| 2017 |
Hu D, Gao X, Cao K, Morgan MA, Mas G, Smith ER, Volk AG, Bartom ET, Crispino JD, Di Croce L, Shilatifard A. Not All H3K4 Methylations Are Created Equal: Mll2/COMPASS Dependency in Primordial Germ Cell Specification. Molecular Cell. 65: 460-475.e6. PMID 28157506 DOI: 10.1016/J.Molcel.2017.01.013 |
0.416 |
|
| 2017 |
Liang K, Volk AG, Haug JS, Marshall SA, Woodfin AR, Bartom ET, Gilmore JM, Florens L, Washburn MP, Sullivan KD, Espinosa JM, Cannova J, Zhang J, Smith ER, Crispino JD, et al. Therapeutic Targeting of MLL Degradation Pathways in MLL-Rearranged Leukemia. Cell. PMID 28065413 DOI: 10.1016/J.Cell.2016.12.011 |
0.438 |
|
| 2016 |
Yang Q, Crispino JD, Wen QJ. Kinase signaling and targeted therapy for primary myelofibrosis. Experimental Hematology. PMID 28043820 DOI: 10.1016/J.Exphem.2016.12.007 |
0.39 |
|
| 2016 |
Suraneni PK, Crispino JD. The Hippo-p53 pathway in megakaryopoiesis. Haematologica. 101: 1446-1448. PMID 27903710 DOI: 10.3324/Haematol.2016.156125 |
0.384 |
|
| 2016 |
Jin Q, Ren Y, Wang M, Suraneni PK, Li D, Crispino JD, Fan J, Huang Z. Novel function of FAXDC2 in megakaryopoiesis. Blood Cancer Journal. 6: e478. PMID 27689744 DOI: 10.1038/Bcj.2016.87 |
0.471 |
|
| 2016 |
Kirsammer G, Crispino JD. Signaling a link between interferon and the traits of Down syndrome. Elife. 5. PMID 27599162 DOI: 10.7554/Elife.20196 |
0.751 |
|
| 2016 |
Fisher JB, Peterson J, Reimer M, Stelloh C, Pulakanti K, Gerbec ZJ, Abel AM, Strouse JM, Strouse C, McNulty M, Malarkannan S, Crispino JD, Milanovich S, Rao S. The cohesin subunit Rad21 is a negative regulator of hematopoietic self-renewal through epigenetic repression of HoxA7 and HoxA9. Leukemia. PMID 27554164 DOI: 10.1038/Leu.2016.240 |
0.388 |
|
| 2016 |
Lee P, Bhansali R, Izraeli S, Hijiya N, Crispino JD. The biology, pathogenesis and clinical aspects of acute lymphoblastic leukemia in children with down syndrome. Leukemia. PMID 27285583 DOI: 10.1038/Leu.2016.164 |
0.332 |
|
| 2016 |
Yu C, Yang Q, Chen Y, Wang D, Levine R, Crispino J, Wen Q, Huang Z. Tyrosine 625 plays a key role and cooperates with tyrosine 630 in MPL W515L-induced signaling and myeloproliferative neoplasms. Cell & Bioscience. 6: 34. PMID 27222706 DOI: 10.1186/S13578-016-0097-3 |
0.416 |
|
| 2016 |
McNulty M, Crispino JD. iPSCs Offer a New Look at GATA1-Trisomy 21 Cooperation. Cell Stem Cell. 18: 563-4. PMID 27152438 DOI: 10.1016/J.Stem.2016.04.007 |
0.362 |
|
| 2016 |
Kirsammer G, Crispino JD. Signaling a link between interferon and the traits of down syndrome: Elevated interferon signaling is a hallmark of down syndrome Elife. 5. DOI: 10.7554/Elife.201960 |
0.751 |
|
| 2016 |
Wen QJ, Woods B, Yang Q, Sophia C, Lillu G, Rapaport F, Levine RL, Crispino J. Activation of JAK/STAT Signaling in Megakaryocytes Is Necessary and Sufficient for Myeloproliferation In Vivo Blood. 128: 949-949. DOI: 10.1182/Blood.V128.22.949.949 |
0.47 |
|
| 2016 |
Zhao B, Mei Y, Sumagin R, Yang J, Thorsheim C, Zhao L, Stalker TJ, Wen JQ, Crispino J, Abrams CS, Ji P. Pleckstrin-2 Plays an Essential Role in the Pathogenesis of JAK2V617F-Induced Myeloproliferative Neoplasms Blood. 128: 798-798. DOI: 10.1182/Blood.V128.22.798.798 |
0.338 |
|
| 2016 |
Thirant C, Lopez CK, Ignacimouttou C, Diop M, Le Mouël L, Thiollier C, Siret A, Dessen P, Aid Z, Riviere J, Rameau P, Lefebvre C, Khaled M, Leverger G, Ballerini PF, ... ... Crispino J, et al. ETO2-GLIS2 Controls Differentiation Arrest and Self-Renewal through Aberrant Enhancers Regulation in Pediatric Leukemia Blood. 128: 572-572. DOI: 10.1182/Blood.V128.22.572.572 |
0.477 |
|
| 2016 |
Migliaccio ARF, Zingariello M, Sancillo L, Martelli F, Ciaffoni F, Masiello F, Ceglia I, Varricchio L, Rana RA, Zhao C, Crispino J. Ribosomal Deficiency Due to Activation of the Thrombopoietin Axis May be Involved in the Reduced Levels of GATA1 Expressed By Megakaryocytes (MKs) from the Gata1low Model of Myelofibrosis Blood. 128: 4275-4275. DOI: 10.1182/Blood.V128.22.4275.4275 |
0.388 |
|
| 2016 |
Lee P, Bhansali R, Rammohan M, Hijiya N, Izraeli S, Bourquin J, Malinge S, Crispino J. DYRK1A Is a Therapeutic Target in B-ALL in Children with Down Syndrome Blood. 128: 2721-2721. DOI: 10.1182/Blood.V128.22.2721.2721 |
0.509 |
|
| 2016 |
Fisher JB, Peterson J, Reimer M, Stelloh C, Pulakanti K, Gerbec Z, Abel AM, Strouse J, Strouse C, McNulty M, Malarkannan S, Crispino J, Milanovich S, Rao S. The Cohesin Subunit Rad21 Is a Negative Regulator of Hematopoietic Self-Renewal through Epigenetic Repression of HoxA7 and HoxA9 Blood. 128: 1708-1708. DOI: 10.1182/blood.v128.22.1708.1708 |
0.332 |
|
| 2016 |
Ntziachristos P, Arcipowski K, Martinez CA, Zhu Y, Volk AG, Kumar S, Thomas PM, Van Vlierberghe P, Hijiya N, Marshall S, Wang J, Wu J, Kelleher NL, Crispino J. Therapeutic Targeting of the Histone Ubiquitination-Methylation Axis in T Cell Leukemia Blood. 128: 1532-1532. DOI: 10.1182/Blood.V128.22.1532.1532 |
0.443 |
|
| 2016 |
Kirsammer G, Schultz RF, Rastogi R, Gurbuxani S, Crispino J. A PDZ-Binding Motif in DCAF7 Maintains Hematopoietic Homeostasis and Prevents Malignancy in DS-AMKL Blood. 128: 1205-1205. DOI: 10.1182/Blood.V128.22.1205.1205 |
0.818 |
|
| 2015 |
Jeremy Wen Q, Yang Q, Goldenson B, Malinge S, Lasho T, Schneider RK, Breyfogle LJ, Schultz R, Gilles L, Koppikar P, Abdel-Wahab O, Pardanani A, Stein B, Gurbuxani S, Mullally A, ... ... Crispino JD, et al. Targeting megakaryocytic-induced fibrosis in myeloproliferative neoplasms by AURKA inhibition. Nature Medicine. PMID 26569382 DOI: 10.1038/Nm.3995 |
0.378 |
|
| 2015 |
Blobel G, Bodine D, Brand M, Crispino J, De Bruijn M, Nathan D, Pappayannopoulou T, Porcher C, Strouboulis J, Zon L, Higgs DR, Stamatoyannopoulos G, Engel JD. An International Effort to Cure a Global Health Problem: A report on the 19th Hemoglobin Switching Conference. Experimental Hematology. PMID 26143582 DOI: 10.1016/J.Exphem.2015.06.008 |
0.531 |
|
| 2015 |
Volk A, Crispino JD. The role of the chromatin assembly complex (CAF-1) and its p60 subunit (CHAF1b) in homeostasis and disease. Biochimica Et Biophysica Acta. 1849: 979-86. PMID 26066981 DOI: 10.1016/J.Bbagrm.2015.05.009 |
0.305 |
|
| 2015 |
Thompson BJ, Bhansali R, Diebold L, Cook DE, Stolzenburg L, Casagrande AS, Besson T, Leblond B, Désiré L, Malinge S, Crispino JD. DYRK1A controls the transition from proliferation to quiescence during lymphoid development by destabilizing Cyclin D3. The Journal of Experimental Medicine. 212: 953-70. PMID 26008897 DOI: 10.1084/Jem.20150002 |
0.773 |
|
| 2015 |
Chlon TM, McNulty M, Goldenson B, Rosinski A, Crispino JD. Global transcriptome and chromatin occupancy analysis reveal the short isoform of GATA1 is deficient for erythroid specification and gene expression. Haematologica. 100: 575-84. PMID 25682601 DOI: 10.3324/Haematol.2014.112714 |
0.481 |
|
| 2015 |
Goldenson B, Kirsammer G, Stankiewicz MJ, Wen QJ, Crispino JD. Aurora kinase A is required for hematopoiesis but is dispensable for murine megakaryocyte endomitosis and differentiation. Blood. 125: 2141-50. PMID 25670627 DOI: 10.1182/Blood-2014-12-615401 |
0.814 |
|
| 2015 |
Sakamoto KM, Grant S, Saleiro D, Crispino JD, Hijiya N, Giles F, Platanias L, Eklund EA. Targeting novel signaling pathways for resistant acute myeloid leukemia. Molecular Genetics and Metabolism. 114: 397-402. PMID 25533111 DOI: 10.1016/J.Ymgme.2014.11.017 |
0.367 |
|
| 2015 |
Shaham L, Vendramini E, Ge Y, Goren Y, Birger Y, Tijssen MR, McNulty M, Geron I, Schwartzman O, Goldberg L, Chou ST, Pitman H, Weiss MJ, Michaeli S, Sredni B, ... ... Crispino JD, et al. MicroRNA-486-5p is an erythroid oncomiR of the myeloid leukemias of Down syndrome. Blood. 125: 1292-301. PMID 25533034 DOI: 10.1182/Blood-2014-06-581892 |
0.328 |
|
| 2015 |
Lu B, Sun X, Crispino J, Huang Z. ANP32A Dysregulation Involves Histone Modifications and Contributes to Myeloid Leukemia Blood. 126: 2456-2456. DOI: 10.1182/Blood.V126.23.2456.2456 |
0.498 |
|
| 2014 |
Lane AA, Chapuy B, Lin CY, Tivey T, Li H, Townsend EC, van Bodegom D, Day TA, Wu SC, Liu H, Yoda A, Alexe G, Schinzel AC, Sullivan TJ, Malinge S, ... ... Crispino JD, et al. Triplication of a 21q22 region contributes to B cell transformation through HMGN1 overexpression and loss of histone H3 Lys27 trimethylation. Nature Genetics. 46: 618-23. PMID 24747640 DOI: 10.1038/Ng.2949 |
0.385 |
|
| 2014 |
Crispino JD, Weiss MJ. Erythro-megakaryocytic transcription factors associated with hereditary anemia. Blood. 123: 3080-8. PMID 24652993 DOI: 10.1182/Blood-2014-01-453167 |
0.427 |
|
| 2014 |
Liu L, Wen Q, Gong R, Gilles L, Stankiewicz MJ, Li W, Guo M, Li L, Sun X, Li W, Crispino JD, Huang Z. PSTPIP2 dysregulation contributes to aberrant terminal differentiation in GATA-1-deficient megakaryocytes by activating LYN. Cell Death & Disease. 5: e988. PMID 24407241 DOI: 10.1038/Cddis.2013.512 |
0.47 |
|
| 2014 |
Malchenko S, Xie J, de Fatima Bonaldo M, Vanin EF, Bhattacharyya BJ, Belmadani A, Xi G, Galat V, Goossens W, Seftor RE, Tomita T, Crispino J, Miller RJ, Bohn MC, Hendrix MJ, et al. Onset of rosette formation during spontaneous neural differentiation of hESC and hiPSC colonies. Gene. 534: 400-7. PMID 23954875 DOI: 10.1016/J.Gene.2013.07.101 |
0.365 |
|
| 2014 |
Gang EJ, Hsieh YT, Pham J, Zhao Y, Nguyen C, Huantes S, Park E, Naing K, Klemm L, Swaminathan S, Conway EM, Pelus LM, Crispino J, Mullighan CG, McMillan M, et al. Small-molecule inhibition of CBP/catenin interactions eliminates drug-resistant clones in acute lymphoblastic leukemia. Oncogene. 33: 2169-78. PMID 23728349 DOI: 10.1038/Onc.2013.169 |
0.452 |
|
| 2014 |
Gilles L, Arslan AD, Konstantinoff K, McNulty M, Terra L, Pardanani A, Stein BL, Plo I, Vainchenker W, Platanias L, Tefferi A, Crispino JD. Defect in Ribosome Biogenesis Contributes to Impaired Megakaryopoiesis in Primary Myelofibrosis Blood. 124: 4585-4585. DOI: 10.1182/Blood.V124.21.4585.4585 |
0.481 |
|
| 2014 |
Huang Z, Yu C, Wen QJ, Yang Q, Crispino J, Wang D, Chen Y. Tyrosine 599 Plays an Essential Role and Cooperates with Tyrosine 604 in MPL W515L-Indiced Myeloproliferative Neoplasms Blood. 124: 4580-4580. DOI: 10.1182/Blood.V124.21.4580.4580 |
0.469 |
|
| 2014 |
Lane AA, Chapuy B, Lin CY, Tivey T, Li H, Townsend E, Bodegom Dv, Day TA, Wu S, Liu H, Yoda A, Alexe G, Schinzel A, Sullivan TJ, Malinge S, ... ... Crispino JD, et al. Abstract 433: Triplication of HMGN1 promotes B cell acute lymphoblastic leukemia (B-ALL) through suppression of H3K27me3 Cancer Research. 74: 433-433. DOI: 10.1158/1538-7445.Am2014-433 |
0.456 |
|
| 2014 |
Goldenson B, Crispino JD. The aurora kinases in cell cycle and leukemia Oncogene. DOI: 10.1038/Onc.2014.14 |
0.342 |
|
| 2013 |
Malinge S, Chlon T, Doré LC, Ketterling RP, Tallman MS, Paietta E, Gamis AS, Taub JW, Chou ST, Weiss MJ, Crispino JD, Figueroa ME. Development of acute megakaryoblastic leukemia in Down syndrome is associated with sequential epigenetic changes. Blood. 122: e33-43. PMID 23980066 DOI: 10.1182/Blood-2013-05-503011 |
0.358 |
|
| 2013 |
Krause DS, Crispino JD. Molecular pathways: induction of polyploidy as a novel differentiation therapy for leukemia. Clinical Cancer Research : An Official Journal of the American Association For Cancer Research. 19: 6084-8. PMID 23963861 DOI: 10.1158/1078-0432.Ccr-12-2604 |
0.414 |
|
| 2013 |
Khan I, Huang Z, Wen Q, Stankiewicz MJ, Gilles L, Goldenson B, Schultz R, Diebold L, Gurbuxani S, Finke CM, Lasho TL, Koppikar P, Pardanani A, Stein B, Altman JK, ... ... Crispino JD, et al. AKT is a therapeutic target in myeloproliferative neoplasms. Leukemia. 27: 1882-90. PMID 23748344 DOI: 10.1038/Leu.2013.167 |
0.429 |
|
| 2013 |
Birger Y, Goldberg L, Chlon TM, Goldenson B, Muler I, Schiby G, Jacob-Hirsch J, Rechavi G, Crispino JD, Izraeli S. Perturbation of fetal hematopoiesis in a mouse model of Down syndrome's transient myeloproliferative disorder. Blood. 122: 988-98. PMID 23719302 DOI: 10.1182/Blood-2012-10-460998 |
0.455 |
|
| 2013 |
Stankiewicz MJ, Crispino JD. AKT collaborates with ERG and Gata1s to dysregulate megakaryopoiesis and promote AMKL Leukemia. 27: 1339-1347. PMID 23380710 DOI: 10.1038/Leu.2013.33 |
0.449 |
|
| 2013 |
Malinge S, Thiollier C, Chlon TM, Doré LC, Diebold L, Bluteau O, Mabialah V, Vainchenker W, Dessen P, Winandy S, Mercher T, Crispino JD. Ikaros inhibits megakaryopoiesis through functional interaction with GATA-1 and NOTCH signaling. Blood. 121: 2440-51. PMID 23335373 DOI: 10.1182/Blood-2012-08-450627 |
0.521 |
|
| 2013 |
Thompson BJ, Diebold L, Malinge S, Leblond B, Casagrande A, Désiré L, Foucourt A, Besson T, Hijiya N, Crispino JD. The Chromosome 21 Kinase DYRK1A Controls Cell Cycle Exit and Survival During Lymphoid Development and Is a Novel Therapeutic Target In Acute Lymphoblastic Leukemia Blood. 122: 814-814. DOI: 10.1182/Blood.V122.21.814.814 |
0.511 |
|
| 2013 |
Stankiewicz MJ, Chlon TM, Crispino JD. Stage Selective Requirement For The N-Terminus Of GATA1 During Erythropoiesis Blood. 122: 3670-3670. DOI: 10.1182/Blood.V122.21.3670.3670 |
0.495 |
|
| 2013 |
Goldenson B, Wen QJ, Crispino JD. Aurora A Kinase Is Required For Hematopoiesis and Couples Polyploidization With Terminal Differentiation In Megakaryocytes Through Phosphorylation Of NF-E2 Blood. 122: 219-219. DOI: 10.1182/Blood.V122.21.219.219 |
0.446 |
|
| 2013 |
Wen QJ, Goldenson B, Malinge S, Stein BL, Lasho TL, Breyfogle L, Schultz R, Yang Q, gilles-Gendre L, Koppikar P, Abdel-Wahab O, Ebert BL, Pardanani A, Gurbuxani S, Levine RL, ... ... Crispino JD, et al. Aurora A Kinase Is a Novel Therapeutic Target In The Myeloproliferative Neoplasms Blood. 122: 109-109. DOI: 10.1182/Blood.V122.21.109.109 |
0.45 |
|
| 2012 |
Crispino JD, Le Beau MM. BMP meets AML: induction of BMP signaling by a novel fusion gene promotes pediatric acute leukemia. Cancer Cell. 22: 567-8. PMID 23153530 DOI: 10.1016/J.Ccr.2012.10.008 |
0.398 |
|
| 2012 |
Chlon TM, Crispino JD. Combinatorial regulation of tissue specification by GATA and FOG factors. Development (Cambridge, England). 139: 3905-16. PMID 23048181 DOI: 10.1242/Dev.080440 |
0.433 |
|
| 2012 |
Thiollier C, Lopez CK, Gerby B, Ignacimouttou C, Poglio S, Duffourd Y, Guégan J, Rivera-Munoz P, Bluteau O, Mabialah V, Diop M, Wen Q, Petit A, Bauchet AL, Reinhardt D, ... ... Crispino JD, et al. Characterization of novel genomic alterations and therapeutic approaches using acute megakaryoblastic leukemia xenograft models. The Journal of Experimental Medicine. 209: 2017-31. PMID 23045605 DOI: 10.1084/Jem.20121343 |
0.444 |
|
| 2012 |
Wen Q, Goldenson B, Silver SJ, Schenone M, Dancik V, Huang Z, Wang LZ, Lewis TA, An WF, Li X, Bray MA, Thiollier C, Diebold L, Gilles L, Vokes MS, ... ... Crispino JD, et al. Identification of regulators of polyploidization presents therapeutic targets for treatment of AMKL. Cell. 150: 575-89. PMID 22863010 DOI: 10.1016/J.Cell.2012.06.032 |
0.416 |
|
| 2012 |
Crispino JD. JAKing up AML1-ETO. Blood. 120: 703-4. PMID 22835885 DOI: 10.1182/Blood-2012-05-413104 |
0.332 |
|
| 2012 |
Chlon TM, Doré LC, Crispino JD. Cofactor-mediated restriction of GATA-1 chromatin occupancy coordinates lineage-specific gene expression. Molecular Cell. 47: 608-21. PMID 22771118 DOI: 10.1016/J.Molcel.2012.05.051 |
0.417 |
|
| 2012 |
Keerthivasan G, Liu H, Gump JM, Dowdy SF, Wickrema A, Crispino JD. A novel role for survivin in erythroblast enucleation. Haematologica. 97: 1471-9. PMID 22491741 DOI: 10.3324/Haematol.2011.061093 |
0.424 |
|
| 2012 |
Doré LC, Chlon TM, Brown CD, White KP, Crispino JD. Chromatin occupancy analysis reveals genome-wide GATA factor switching during hematopoiesis. Blood. 119: 3724-33. PMID 22383799 DOI: 10.1182/Blood-2011-09-380634 |
0.419 |
|
| 2012 |
Malinge S, Bliss-Moreau M, Kirsammer G, Diebold L, Chlon T, Gurbuxani S, Crispino JD. Increased dosage of the chromosome 21 ortholog Dyrk1a promotes megakaryoblastic leukemia in a murine model of Down syndrome. The Journal of Clinical Investigation. 122: 948-62. PMID 22354171 DOI: 10.1172/Jci60455 |
0.806 |
|
| 2012 |
Galat V, Malchenko S, Galat Y, Ishkin A, Nikolsky Y, Kosak ST, Soares BM, Iannaccone P, Crispino JD, Hendrix MJ. A model of early human embryonic stem cell differentiation reveals inter- and intracellular changes on transition to squamous epithelium. Stem Cells and Development. 21: 1250-63. PMID 21861759 DOI: 10.1089/Scd.2010.0578 |
0.404 |
|
| 2012 |
Liu L, Liu S, Wen QJ, Crispino J, Huang Z. Dysregulation of PSTPIP2 Due to Loss of GATA-1 Contributes to Aberrant Megakaryopoiesis Blood. 120: 854-854. DOI: 10.1182/Blood.V120.21.854.854 |
0.503 |
|
| 2012 |
Wang Y, Hayes VM, Lu L, Chen X, Fuentes R, Wen QJ, Chou ST, Crispino J, Paddison P, French DL, Torok-Storb B, Poncz M. Aryl Hydrocarbon Receptor (AhR) Antagonist Stemregenin 1 (SR1) Enhances in Vitro- and in Vivo-Derived Platelets (PLTs) From Human Megakaryocytes (MKs) Blood. 120: 3450-3450. DOI: 10.1182/Blood.V120.21.3450.3450 |
0.387 |
|
| 2012 |
Gilles L, Finke C, Lasho TL, Pardanani A, Tefferi A, Crispino J. Aberrant Megakaryocyte Gene Expression Contributes to Primary Myelofibrosis. Blood. 120: 2867-2867. DOI: 10.1182/Blood.V120.21.2867.2867 |
0.453 |
|
| 2012 |
Goldenson B, Wen JQ, Crispino J. Aurora A Kinase Is Required for Hematopoiesis Blood. 120: 1201-1201. DOI: 10.1182/Blood.V120.21.1201.1201 |
0.465 |
|
| 2012 |
Lane AA, van Bodegom D, Chapuy B, Alexe G, Sullivan TJ, Tivey T, Day T, Crispino J, Fox E, Stegmaier K, Weinstock D. Trisomy of the Down Syndrome Critical Region Suppresses Precursor B-Cell Differentiation and Promotes B-Cell Transformation Associated with Altered Expression of Polycomb Repressor Complex 2 Targets Blood. 120: 115-115. DOI: 10.1182/Blood.V120.21.115.115 |
0.429 |
|
| 2011 |
Rice KL, Lin X, Wolniak K, Ebert BL, Berkofsky-Fessler W, Buzzai M, Sun Y, Xi C, Elkin P, Levine R, Golub T, Gilliland DG, Crispino JD, Licht JD, Zhang W. Analysis of genomic aberrations and gene expression profiling identifies novel lesions and pathways in myeloproliferative neoplasms. Blood Cancer Journal. 1: e40. PMID 22829077 DOI: 10.1038/Bcj.2011.39 |
0.355 |
|
| 2011 |
Khan I, Malinge S, Crispino JD. Myeloid leukemia in down syndrome Critical Reviews in Oncogenesis. 16: 25-36. PMID 22150305 DOI: 10.1615/Critrevoncog.V16.I1-2.40 |
0.375 |
|
| 2011 |
Wen Q, Goldenson B, Crispino JD. Normal and malignant megakaryopoiesis. Expert Reviews in Molecular Medicine. 13: e32. PMID 22018018 DOI: 10.1017/S1462399411002043 |
0.417 |
|
| 2011 |
Stein BL, Crispino JD, Moliterno AR. Janus kinase inhibitors: an update on the progress and promise of targeted therapy in the myeloproliferative neoplasms. Current Opinion in Oncology. 23: 609-16. PMID 21993415 DOI: 10.1097/Cco.0B013E32834D1B22 |
0.308 |
|
| 2011 |
Mali RS, Ramdas B, Ma P, Shi J, Munugalavadla V, Sims E, Wei L, Vemula S, Nabinger SC, Goodwin CB, Chan RJ, Traina F, Visconte V, Tiu RV, Lewis TA, ... ... Crispino JD, et al. Rho kinase regulates the survival and transformation of cells bearing oncogenic forms of KIT, FLT3, and BCR-ABL. Cancer Cell. 20: 357-69. PMID 21907926 DOI: 10.1016/J.Ccr.2011.07.016 |
0.433 |
|
| 2011 |
Park E, Gang EJ, Hsieh YT, Schaefer P, Chae S, Klemm L, Huantes S, Loh M, Conway EM, Kang ES, Hoe Koo H, Hofmann WK, Heisterkamp N, Pelus L, Keerthivasan G, ... Crispino J, et al. Targeting survivin overcomes drug resistance in acute lymphoblastic leukemia. Blood. 118: 2191-9. PMID 21715311 DOI: 10.1182/Blood-2011-04-351239 |
0.311 |
|
| 2011 |
Eliades A, Papadantonakis N, Bhupatiraju A, Burridge KA, Johnston-Cox HA, Migliaccio AR, Crispino JD, Lucero HA, Trackman PC, Ravid K. Control of megakaryocyte expansion and bone marrow fibrosis by lysyl oxidase. The Journal of Biological Chemistry. 286: 27630-8. PMID 21665949 DOI: 10.1074/Jbc.M111.243113 |
0.418 |
|
| 2011 |
Doré LC, Crispino JD. Transcription factor networks in erythroid cell and megakaryocyte development. Blood. 118: 231-9. PMID 21622645 DOI: 10.1182/Blood-2011-04-285981 |
0.409 |
|
| 2011 |
Malinge S, Crispino J. Notch: of mice and men? Blood. 116: 5438-9. PMID 21163933 DOI: 10.1182/Blood-2010-09-308395 |
0.336 |
|
| 2011 |
Wen QJ, Goldenson B, Malinge S, Koppikar P, Levine RL, Tefferi A, Crispino J. Induction of Megakaryocyte Polyploidization in Combination with JAK Inhibition As a Novel Therapeutic Strategy for Myeloproliferative Neoplasms Blood. 118: 64-64. DOI: 10.1182/Blood.V118.21.64.64 |
0.481 |
|
| 2011 |
Khan I, Huang Z, Wen QJ, Koppikar P, Levine RL, Tefferi A, Crispino J. Inhibition of AKT Signaling Potently Inhibits the Growth of JAK and MPL-Mutant Cells in the Myeloproliferative Neoplasms In Vitro and In Vivo, Blood. 118: 3862-3862. DOI: 10.1182/Blood.V118.21.3862.3862 |
0.436 |
|
| 2011 |
Figueroa ME, Malinge S, Chlon TM, Li Y, Paietta E, Fernandez HF, Tallman MS, Weiss MJ, Chou ST, Melnick A, Crispino J. Development of Acute Megakaryoblastic Leukemia in Down Syndrome Is Associated with Sequential Epigenetic Changes That Target the Down Syndrome Critical Region on Chromosome 21, Blood. 118: 3451-3451. DOI: 10.1182/Blood.V118.21.3451.3451 |
0.377 |
|
| 2011 |
Keerthivasan G, Ghinassi B, Wilmes JS, Wickrema A, Migliaccio ARF, Duban M, Crispino J. Vacuolin-1 Promotes Enucleation of Cultured Human and Murine Erythroblasts Blood. 118: 2321-2321. DOI: 10.1182/Blood.V118.21.2321.2321 |
0.427 |
|
| 2011 |
Keerthivasan G, Liu H, Gump JM, Dowdy SF, Wickrema A, Crispino JD. Abstract 2984: A novel role for survivin, a potential target for cancer drugs, in vesicle trafficking Cancer Research. 71: 2984-2984. DOI: 10.1158/1538-7445.Am2011-2984 |
0.467 |
|
| 2010 |
Small S, Keerthivasan G, Huang Z, Gurbuxani S, Crispino JD. Overexpression of survivin initiates hematologic malignancies in vivo Leukemia. 24: 1920-1926. PMID 20882051 DOI: 10.1038/Leu.2010.198 |
0.443 |
|
| 2010 |
Huang QQ, Perlman H, Huang Z, Birkett R, Kan L, Agrawal H, Misharin A, Gurbuxani S, Crispino JD, Pope RM. FLIP: a novel regulator of macrophage differentiation and granulocyte homeostasis. Blood. 116: 4968-77. PMID 20724542 DOI: 10.1182/Blood-2009-11-252841 |
0.398 |
|
| 2010 |
Keerthivasan G, Small S, Liu H, Wickrema A, Crispino JD. Vesicle trafficking plays a novel role in erythroblast enucleation. Blood. 116: 3331-40. PMID 20644112 DOI: 10.1182/Blood-2010-03-277426 |
0.369 |
|
| 2010 |
Gao Z, Huang Z, Olivey HE, Gurbuxani S, Crispino JD, Svensson EC. FOG-1-mediated recruitment of NuRD is required for cell lineage re-enforcement during haematopoiesis. The Embo Journal. 29: 457-68. PMID 20010697 DOI: 10.1038/Emboj.2009.368 |
0.443 |
|
| 2010 |
Wen QJ, Silver S, Lewis T, Ponduru S, Dancik V, Goldenson B, Bray M, Carpenter A, Clemons P, Root D, Stern A, Gould R, Crispino J. A Kinome shRNA Screen to Identify Pathways That Regulate Megakaryocyte Polyploidization and New Targets for Differentiation Therapy Blood. 116: 89-89. DOI: 10.1182/Blood.V116.21.89.89 |
0.454 |
|
| 2010 |
Fukuda S, Singh P, Hoggatt J, Speth J, Abe M, Conway EM, Crispino J, Nucifora G, Yamaguchi S, Pelus LM. Survivin Modulates Gene Expression That Connects through An Extensive Functional Signaling Network and Regulates Proliferation of Hematopoietic Stem Cells through Evi-1 Blood. 116: 87-87. DOI: 10.1182/Blood.V116.21.87.87 |
0.497 |
|
| 2010 |
Malinge S, Kirsammer G, Bliss-Moreau M, Chlon TM, Diebold L, Chou ST, Weiss M, Gurbuxani S, Crispino J. Development of a Mouse Model of DS Megakaryoblastic Leukemia and Identification of the Hsa21 Gene DYRK1A as a Prominent Contributor to DS-AMKL Blood. 116: 469-469. DOI: 10.1182/Blood.V116.21.469.469 |
0.824 |
|
| 2010 |
Chlon TM, Dore LC, Crispino J. The Leukemic Isoform GATA-1s Is Deficient In Chromatin Occupancy: Implications for AMKL. Blood. 116: 3643-3643. DOI: 10.1182/Blood.V116.21.3643.3643 |
0.446 |
|
| 2010 |
Park E, Jiang E, Hsieh Y, Klemm L, Duy C, Conway EM, Pelus LM, Crispino J, Loh ML, Kang E, Koo H, Yang A, Heisterkamp N, Kahn M, Muschen M, et al. Targeting Survivin In Recalcitrant Acute Lymphoblastic Leukemia Blood. 116: 3263-3263. DOI: 10.1182/Blood.V116.21.3263.3263 |
0.389 |
|
| 2010 |
Dore LC, Chlon TM, Huang Z, Crispino J. Identification of a GATA Switch In Megakaryocytic Development. Blood. 116: 2605-2605. DOI: 10.1182/Blood.V116.21.2605.2605 |
0.453 |
|
| 2010 |
Yang Z, Chlon TM, Crispino J, Rosmarin AG. Gabp Transcription Factor Is Required for the Development of Mouse Megakaryocytes. Blood. 116: 2604-2604. DOI: 10.1182/Blood.V116.21.2604.2604 |
0.436 |
|
| 2010 |
Malinge S, Thiollier C, Chlon TM, Dore LC, Diebold L, Winandy S, Mercher T, Crispino J. Ikaros Is a GATA Switch Target Gene That Restrains Megakaryopoiesis In Part by Blocking Notch Signaling. Blood. 116: 1602-1602. DOI: 10.1182/Blood.V116.21.1602.1602 |
0.552 |
|
| 2009 |
Bhat R, Malinge S, Gamis AS, Sorrell AD, Hilden JM, Ketterling RP, Paietta E, Tallman MS, Crispino JD. Mutational analysis of candidate tumor-associated genes in acute megakaryoblastic leukemia Leukemia. 23: 2159-2160. PMID 19657363 DOI: 10.1038/Leu.2009.159 |
0.328 |
|
| 2009 |
Huang Z, Dore LC, Li Z, Orkin SH, Feng G, Lin S, Crispino JD. GATA-2 reinforces megakaryocyte development in the absence of GATA-1. Molecular and Cellular Biology. 29: 5168-80. PMID 19620289 DOI: 10.1128/Mcb.00482-09 |
0.636 |
|
| 2009 |
Chou ST, Khandros E, Bailey LC, Nichols KE, Vakoc CR, Yao Y, Huang Z, Crispino JD, Hardison RC, Blobel GA, Weiss MJ. Graded repression of PU.1/Sfpi1 gene transcription by GATA factors regulates hematopoietic cell fate. Blood. 114: 983-94. PMID 19491391 DOI: 10.1182/Blood-2009-03-207944 |
0.653 |
|
| 2009 |
Abdel-Wahab O, Mullally A, Hedvat C, Garcia-Manero G, Patel J, Wadleigh M, Malinge S, Yao J, Kilpivaara O, Bhat R, Huberman K, Thomas S, Dolgalev I, Heguy A, Paietta E, ... ... Crispino JD, et al. Genetic characterization of TET1, TET2, and TET3 alterations in myeloid malignancies. Blood. 114: 144-7. PMID 19420352 DOI: 10.1182/Blood-2009-03-210039 |
0.342 |
|
| 2009 |
Wen Q, Leung C, Huang Z, Small S, Reddi AL, Licht JD, Crispino JD. Survivin is not required for the endomitotic cell cycle of megakaryocytes. Blood. 114: 153-6. PMID 19339696 DOI: 10.1182/Blood-2008-11-190801 |
0.745 |
|
| 2009 |
Stankiewicz MJ, Crispino JD. ETS2 and ERG promote megakaryopoiesis and synergize with alterations in GATA-1 to immortalize hematopoietic progenitor cells. Blood. 113: 3337-47. PMID 19168790 DOI: 10.1182/Blood-2008-08-174813 |
0.475 |
|
| 2009 |
Malinge S, Izraeli S, Crispino JD. Insights into the manifestations, outcomes, and mechanisms of leukemogenesis in Down syndrome. Blood. 113: 2619-28. PMID 19139078 DOI: 10.1182/Blood-2008-11-163501 |
0.344 |
|
| 2009 |
Wen Q, Huang Z, Small S, Bubna N, An F, Bliss-Moreau M, Verplank L, Lewis T, Schenone M, Tolliday N, Moore C, Carpenter A, Mercher T, Levine RL, Izraeli S, ... ... Crispino J, et al. Identification of Inducers of Megakaryocyte Polyploidization and Their Use as Targeted Differentiation Therapy for Acute Megakaryocytic Leukemia. Blood. 114: 792-792. DOI: 10.1182/Blood.V114.22.792.792 |
0.492 |
|
| 2009 |
Smooha G, Birger Y, Goldberg L, Jacob-Hirsch J, Amariglio N, Rechavi G, Levanon D, Groner Y, Taragan A, Kloog Y, Wen JQ, Crispino J, Radmacher MD, Marcucci G, Bloomfield CD, et al. MODELING and Targeting ERG-INDUCED Acute MYELOID LEUKEMIA (AML). Blood. 114: 475-475. DOI: 10.1182/Blood.V114.22.475.475 |
0.469 |
|
| 2009 |
Bartholdy B, Yamamoto Y, Evans E, Crispino J, Tenen DG. PU.1 - c-Jun Interactions Are Crucial for PU.1 Function in Myeloid Development. Blood. 114: 3651-3651. DOI: 10.1182/Blood.V114.22.3651.3651 |
0.47 |
|
| 2009 |
Huang Z, Koppikar P, Mercher T, Levine RL, Crispino J. Inhibition of AKT Signaling Potently Inhibits Growth of MPL-Mutant Cells in the Myeloproliferative Neoplasms. Blood. 114: 1896-1896. DOI: 10.1182/Blood.V114.22.1896.1896 |
0.473 |
|
| 2008 |
McCrann DJ, Yezefski T, Nguyen HG, Papadantonakis N, Liu H, Wen Q, Crispino JD, Ravid K. Survivin overexpression alone does not alter megakaryocyte ploidy nor interfere with erythroid/megakaryocytic lineage development in transgenic mice. Blood. 111: 4092-5. PMID 18245663 DOI: 10.1182/Blood-2007-11-122150 |
0.424 |
|
| 2008 |
Kang JA, Zhou Y, Weis TL, Liu H, Ulaszek J, Satgurunathan N, Zhou L, van Besien K, Crispino J, Verma A, Low PS, Wickrema A. Osteopontin regulates actin cytoskeleton and contributes to cell proliferation in primary erythroblasts. The Journal of Biological Chemistry. 283: 6997-7006. PMID 18174176 DOI: 10.1074/Jbc.M706712200 |
0.42 |
|
| 2008 |
Kirsammer G, Jilani S, Liu H, Davis E, Gurbuxani S, Le Beau MM, Crispino JD. Highly penetrant myeloproliferative disease in the Ts65Dn mouse model of Down syndrome. Blood. 111: 767-75. PMID 17901249 DOI: 10.1182/Blood-2007-04-085670 |
0.808 |
|
| 2008 |
Keerthivasan G, Small S, Liu H, Wickrema A, Crispino J. Endocytosis and Erythroblast Enucleation Are Linked by the Action of a Survivin-EPS15-Clathrin Complex Blood. 112: 534-534. DOI: 10.1182/Blood.V112.11.534.534 |
0.434 |
|
| 2008 |
Stankiewicz MJ, Crispino J. Ectopic Expression of ERG and FLI1 Enforce a Megakaryocyte Phenotype Independent of GATA-1 Blood. 112: 2841-2841. DOI: 10.1182/Blood.V112.11.2841.2841 |
0.487 |
|
| 2008 |
Chou ST, Bailey C, Yao Y, Huang Z, Nichols K, Crispino J, Hardison R, Blobel G, Vakoc C, Weiss MJ. Graded Repression of PU.1 Expression by GATA Factors Influence Hematopoietic Progenitor Cell Fate Blood. 112: 2469-2469. DOI: 10.1182/Blood.V112.11.2469.2469 |
0.635 |
|
| 2008 |
Huang Z, Crispino J. GATA-2 Controls Proliferation of Megakaryocyte Progenitors and Its Expression Contributes to Human DS-AMKL. Blood. 112: 1380-1380. DOI: 10.1182/Blood.V112.11.1380.1380 |
0.528 |
|
| 2008 |
Wen JQ, Leung C, Huang Z, Small S, Crispino J. Survivin Is Required for Proliferation, but Not Polyploidization of Megakaryocytes. Blood. 112: 1328-1328. DOI: 10.1182/Blood.V112.11.1328.1328 |
0.755 |
|
| 2007 |
Huang Z, Richmond TD, Muntean AG, Barber DL, Weiss MJ, Crispino JD. STAT1 promotes megakaryopoiesis downstream of GATA-1 in mice. The Journal of Clinical Investigation. 117: 3890-9. PMID 18060035 DOI: 10.1172/Jci33010 |
0.73 |
|
| 2007 |
Wickrema A, Crispino JD. Erythroid and megakaryocytic transformation Oncogene. 26: 6803-6815. PMID 17934487 DOI: 10.1038/Sj.Onc.1210763 |
0.397 |
|
| 2007 |
Norton A, Fisher C, Liu H, Wen Q, Mundschau G, Fuster JL, Hasle H, Zeller B, Webb DK, O'Marcaigh A, Sorrell A, Hilden J, Gamis A, Crispino JD, Vyas P. Analysis of JAK3, JAK2, and C-MPL mutations in transient myeloproliferative disorder and myeloid leukemia of Down syndrome blasts in children with Down syndrome. Blood. 110: 1077-9. PMID 17644747 DOI: 10.1182/Blood-2007-03-080374 |
0.325 |
|
| 2007 |
Leung CG, Xu Y, Mularski B, Liu H, Gurbuxani S, Crispino JD. Requirements for survivin in terminal differentiation of erythroid cells and maintenance of hematopoietic stem and progenitor cells. The Journal of Experimental Medicine. 204: 1603-11. PMID 17576776 DOI: 10.1084/Jem.20062395 |
0.798 |
|
| 2007 |
Joslin JM, Fernald AA, Tennant TR, Davis EM, Kogan SC, Anastasi J, Crispino JD, Le Beau MM. Haploinsufficiency of EGR1, a candidate gene in the del(5q), leads to the development of myeloid disorders. Blood. 110: 719-26. PMID 17420284 DOI: 10.1182/Blood-2007-01-068809 |
0.44 |
|
| 2007 |
Muntean AG, Pang L, Poncz M, Dowdy SF, Blobel GA, Crispino JD. Cyclin D-Cdk4 is regulated by GATA-1 and required for megakaryocyte growth and polyploidization. Blood. 109: 5199-207. PMID 17317855 DOI: 10.1182/Blood-2006-11-059378 |
0.763 |
|
| 2007 |
Vyas P, Crispino JD. Molecular insights into Down syndrome-associated leukemia. Current Opinion in Pediatrics. 19: 9-14. PMID 17224656 DOI: 10.1097/Mop.0B013E328013E7B2 |
0.382 |
|
| 2007 |
Stankiewicz MJ, Crispino JD. ETS2 and ERG1 Promote Megakaryopoiesis and Immortalize GATA1 Knockdown (ΔneoΔHS) Fetal Liver Progenitors: Implications for Leukemogenesis in Down Syndrome. Blood. 110: 824-824. DOI: 10.1182/Blood.V110.11.824.824 |
0.48 |
|
| 2007 |
Keerthivasan G, Kang JA, Seferos DS, Mirkin CA, Wickrema A, Crispino JD. A Role for Survivin in Enucleation of Erythroid Progenitors. Blood. 110: 1704-1704. DOI: 10.1182/Blood.V110.11.1704.1704 |
0.431 |
|
| 2007 |
Muntean A, Pang L, Poncz M, Dowdy S, Blobel G, Crispino J. Cyclin D/CDK4/6 kinase activity, regulated by GATA1, is required for megakaryocyte polyploidization Blood Cells, Molecules, and Diseases. 38: 133. DOI: 10.1182/Blood.V108.11.780.780 |
0.783 |
|
| 2006 |
Walters DK, Mercher T, Gu TL, O'Hare T, Tyner JW, Loriaux M, Goss VL, Lee KA, Eide CA, Wong MJ, Stoffregen EP, McGreevey L, Nardone J, Moore SA, Crispino J, et al. Activating alleles of JAK3 in acute megakaryoblastic leukemia. Cancer Cell. 10: 65-75. PMID 16843266 DOI: 10.1016/J.Ccr.2006.06.002 |
0.402 |
|
| 2006 |
Muntean AG, Ge Y, Taub JW, Crispino JD. Transcription factor GATA-1 and Down syndrome leukemogenesis. Leukemia & Lymphoma. 47: 986-97. PMID 16840187 DOI: 10.1080/10428190500485810 |
0.746 |
|
| 2006 |
Mundschau G, Crispino J. GATA1s goes germline. Nature Genetics. 38: 741-2. PMID 16804537 DOI: 10.1038/Ng0706-741 |
0.396 |
|
| 2006 |
Xu Y, Leung CG, Lee DC, Kennedy BK, Crispino JD. MTB, the murine homolog of condensin II subunit CAP-G2, represses transcription and promotes erythroid cell differentiation. Leukemia. 20: 1261-9. PMID 16673016 DOI: 10.1038/Sj.Leu.2404252 |
0.78 |
|
| 2006 |
Crispino JD, Leung C, Xu Y, Mularski B, Liu H, Gurbuxani S. Survivin Is Required for Terminal Differentiation of Erythroid Cells as Well as for the Proliferation and/or Survival of Hematopoietic Progenitors. Blood. 108: 81-81. DOI: 10.1182/Blood.V108.11.81.81 |
0.661 |
|
| 2006 |
Huang Z, Crispino JD. STAT1 Promotes Megakaryocytic Differentiation in a GATA-1-Independent Manner. Blood. 108: 1157-1157. DOI: 10.1182/Blood.V108.11.1157.1157 |
0.483 |
|
| 2006 |
Crispino JD. Up and down in Down syndrome: AMKL Blood. 107: 1251-1252. DOI: 10.1182/Blood-2005-11-4672 |
0.388 |
|
| 2005 |
Gurbuxani S, Xu Y, Keerthivasan G, Wickrema A, Crispino JD. Differential requirements for survivin in hematopoietic cell development. Proceedings of the National Academy of Sciences of the United States of America. 102: 11480-5. PMID 16055565 DOI: 10.1182/Blood.V104.11.1257.1257 |
0.651 |
|
| 2005 |
Muntean AG, Crispino JD. Differential requirements for the activation domain and FOG-interaction surface of GATA-1 in megakaryocyte gene expression and development. Blood. 106: 1223-31. PMID 15860665 DOI: 10.1182/Blood-2005-02-0551 |
0.751 |
|
| 2005 |
Crispino JD. GATA1 in normal and malignant hematopoiesis. Seminars in Cell & Developmental Biology. 16: 137-47. PMID 15659348 DOI: 10.1016/J.Semcdb.2004.11.002 |
0.436 |
|
| 2005 |
Crispino JD. GATA1 mutations in Down syndrome: implications for biology and diagnosis of children with transient myeloproliferative disorder and acute megakaryoblastic leukemia. Pediatric Blood & Cancer. 44: 40-4. PMID 15390312 DOI: 10.1002/Pbc.20066 |
0.4 |
|
| 2005 |
Joslin JM, Fernald AA, Qian Z, Crispino JD, Le Beau MM. Egr1, a Candidate Gene within the Commonly Deleted Segment of Chromosome 5, Plays a Role in Murine Erythropoiesis and Leukemogenesis. Blood. 106: 663-663. DOI: 10.1182/Blood.V106.11.663.663 |
0.479 |
|
| 2005 |
Mundschau G, Jilani S, Liu H, Davis E, Le Beau M, Crispino J. Myeloproliferative Disease in a Mouse Model of Down Syndrome. Blood. 106: 4946-4946. DOI: 10.1182/Blood.V106.11.4946.4946 |
0.449 |
|
| 2004 |
Taub JW, Mundschau G, Ge Y, Poulik JM, Qureshi F, Jensen T, James SJ, Matherly LH, Wechsler J, Crispino JD. Prenatal origin of GATA1 mutations may be an initiating step in the development of megakaryocytic leukemia in Down syndrome. Blood. 104: 1588-9. PMID 15317736 DOI: 10.1182/Blood-2004-04-1563 |
0.393 |
|
| 2004 |
Smith ED, Xu Y, Tomson BN, Leung CG, Fujiwara Y, Orkin SH, Crispino JD. More than blood, a novel gene required for mammalian postimplantation development. Molecular and Cellular Biology. 24: 1168-73. PMID 14729962 DOI: 10.1128/Mcb.24.3.1168-1173.2004 |
0.791 |
|
| 2004 |
Gurbuxani S, Vyas P, Crispino JD. Recent insights into the mechanisms of myeloid leukemogenesis in Down syndrome. Blood. 103: 399-406. PMID 14512321 DOI: 10.1182/Blood-2003-05-1556 |
0.491 |
|
| 2004 |
Mundschau G, Jilani S, Le Beau M, Crispino J. Hematopoiesis in the Ts65Dn Mouse Model of Down Syndrome (DS) Recapitulates Many Features of Human DS. Blood. 104: 1122-1122. DOI: 10.1182/Blood.V104.11.1122.1122 |
0.427 |
|
| 2003 |
Greene ME, Mundschau G, Wechsler J, McDevitt M, Gamis A, Karp J, Gurbuxani S, Arceci R, Crispino JD. Mutations in GATA1 in both transient myeloproliferative disorder and acute megakaryoblastic leukemia of Down syndrome. Blood Cells, Molecules & Diseases. 31: 351-6. PMID 14636651 DOI: 10.1016/J.Bcmd.2003.08.001 |
0.4 |
|
| 2003 |
Karnauskas R, Niu Q, Talapatra S, Plas DR, Greene ME, Crispino JD, Rudin CM. Bcl-x(L) and Akt cooperate to promote leukemogenesis in vivo. Oncogene. 22: 688-98. PMID 12569361 DOI: 10.1038/Sj.Onc.1206159 |
0.394 |
|
| 2003 |
Mundschau G, Gurbuxani S, Gamis AS, Greene ME, Arceci RJ, Crispino JD. Mutagenesis of GATA1 is an initiating event in Down syndrome leukemogenesis. Blood. 101: 4298-300. PMID 12560215 DOI: 10.1182/Blood-2002-12-3904 |
0.368 |
|
| 2002 |
Wang X, Crispino JD, Letting DL, Nakazawa M, Poncz M, Blobel GA. Control of megakaryocyte-specific gene expression by GATA-1 and FOG-1: role of Ets transcription factors. The Embo Journal. 21: 5225-34. PMID 12356738 DOI: 10.1093/Emboj/Cdf527 |
0.623 |
|
| 2002 |
Tevosian SG, Albrecht KH, Crispino JD, Fujiwara Y, Eicher EM, Orkin SH. Gonadal differentiation, sex determination and normal Sry expression in mice require direct interaction between transcription partners GATA4 and FOG2. Development (Cambridge, England). 129: 4627-34. PMID 12223418 |
0.753 |
|
| 2002 |
Wechsler J, Greene M, McDevitt MA, Anastasi J, Karp JE, Le Beau MM, Crispino JD. Acquired mutations in GATA1 in the megakaryoblastic leukemia of Down syndrome. Nature Genetics. 32: 148-52. PMID 12172547 DOI: 10.1038/Ng955 |
0.451 |
|
| 2002 |
Chang AN, Cantor AB, Fujiwara Y, Lodish MB, Droho S, Crispino JD, Orkin SH. GATA-factor dependence of the multitype zinc-finger protein FOG-1 for its essential role in megakaryopoiesis. Proceedings of the National Academy of Sciences of the United States of America. 99: 9237-42. PMID 12077323 DOI: 10.1073/Pnas.142302099 |
0.728 |
|
| 2002 |
Crispino JD, Orkin SH. The use of altered specificity mutants to probe specific protein-protein interactions involved in the activation of GATA-1 target genes. Methods (San Diego, Calif.). 26: 84-92. PMID 12054907 DOI: 10.1016/S1046-2023(02)00010-5 |
0.49 |
|
| 2001 |
Crispino JD, Lodish MB, Thurberg BL, Litovsky SH, Collins T, Molkentin JD, Orkin SH. Proper coronary vascular development and heart morphogenesis depend on interaction of GATA-4 with FOG cofactors Genes and Development. 15: 839-844. PMID 11297508 DOI: 10.1101/Gad.875201 |
0.399 |
|
| 2000 |
Querfurth E, Schuster M, Kulessa H, Crispino JD, Döderlein G, Orkin SH, Graf T, Nerlov C. Antagonism between C/EBPβ and FOG in eosinophil lineage commitment of multipotent hematopoietic progenitors Genes and Development. 14: 2515-2525. PMID 11018018 DOI: 10.1101/Gad.177200 |
0.517 |
|
| 2000 |
Deconinck AE, Mead PE, Tevosian SG, Crispino JD, Katz SG, Zon LI, Orkin SH. FOG acts as a repressor of red blood cell development in Xenopus Development. 127: 2031-2040. PMID 10769228 |
0.629 |
|
| 2000 |
Nichols KE, Crispino JD, Poncz M, White JG, Orkin SH, Maris JM, Weiss MJ. Familial dyserythropoietic anaemia and thrombocytopenia due to an inherited mutation in GATA 1 Nature Genetics. 24: 266-270. PMID 10700180 DOI: 10.1038/73480 |
0.512 |
|
| 1999 |
Crispino JD, Lodish MB, MacKay JP, Orkin SH. Use of altered specificity mutants to probe a specific protein-protein interaction in differentiation: The GATA-1:FOG complex Molecular Cell. 3: 219-228. PMID 10078204 DOI: 10.1016/S1097-2765(00)80312-3 |
0.449 |
|
| 1997 |
Macmillan AM, Mccaw PS, Crispino JD, Sharp PA. SC35-mediated reconstitution of splicing in U2AF-depleted nuclear extract Proceedings of the National Academy of Sciences of the United States of America. 94: 133-136. PMID 8990173 DOI: 10.1073/Pnas.94.1.133 |
0.478 |
|
| 1996 |
Crispino JD, Mermoud JE, Lamond AI, Sharp PA. Cis-acting elements distinct from the 5' splice site promote U1-independent pre-mRNA splicing. Rna (New York, N.Y.). 2: 664-73. PMID 8756409 |
0.562 |
|
| 1995 |
Crispino JD, Sharp PA. A U6 snRNA:pre-mRNA interaction can be rate-limiting for U1-independent splicing Genes and Development. 9: 2314-2323. PMID 7557384 DOI: 10.1101/Gad.9.18.2314 |
0.455 |
|
| 1994 |
Crispino JD, Blencowe BJ, Sharp PA. Complementation by SR proteins of pre-mRNA splicing reactions depleted of U1 snRNP. Science (New York, N.Y.). 265: 1866-9. PMID 8091213 DOI: 10.1126/Science.8091213 |
0.612 |
|
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